psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:R8	R:R:F344	25.66	No	Yes	0	0	3
2	L:L:R9	R:R:W339	9	No	Yes	0	0	7
3	L:L:P10	R:R:W339	12.16	Yes	Yes	1	0	7
4	L:L:P10	R:R:F344	7.22	Yes	Yes	1	0	3
5	L:L:P10	R:R:Y347	11.13	Yes	Yes	1	0	4
6	L:L:P10	R:R:H348	4.58	Yes	Yes	1	0	4
7	L:L:I12	L:L:Y11	3.63	No	Yes	0	0	0
8	L:L:Y11	R:R:L55	8.21	Yes	No	0	0	2
9	L:L:Y11	R:R:V57	5.05	Yes	Yes	0	0	2
10	L:L:Y11	R:R:V224	5.05	Yes	No	0	0	5
11	L:L:I12	R:R:F128	7.54	No	Yes	1	0	6
12	L:L:I12	R:R:Y351	3.63	No	Yes	1	0	4
13	L:L:L13	R:R:Y146	5.86	Yes	Yes	0	0	5
14	L:L:L13	R:R:R327	3.64	Yes	Yes	0	0	5
15	L:L:L13	R:R:R328	8.5	Yes	No	0	0	6
16	L:L:L13	R:R:F331	3.65	Yes	No	0	0	3
17	R:R:N52	R:R:S214	4.47	No	No	0	3	4
18	R:R:H219	R:R:N52	3.83	No	No	0	3	3
19	R:R:G221	R:R:N52	5.09	No	No	0	4	3
20	R:R:L55	R:R:R213	3.64	No	Yes	0	2	2
21	R:R:D56	R:R:N58	4.04	No	No	0	2	3
22	R:R:H132	R:R:V57	17.99	No	Yes	0	5	2
23	R:R:F344	R:R:V57	3.93	Yes	Yes	1	3	2
24	R:R:H348	R:R:V57	22.14	Yes	Yes	1	4	2
25	R:R:K64	R:R:T59	4.5	No	No	0	5	2
26	R:R:T59	R:R:Y349	7.49	No	No	0	2	1
27	R:R:D60	R:R:Y349	4.6	No	No	0	6	1
28	R:R:I61	R:R:Y62	4.84	No	No	0	3	3
29	R:R:K64	R:R:W130	11.6	No	No	0	5	7
30	R:R:V67	R:R:Y71	7.57	No	Yes	1	5	7
31	R:R:I129	R:R:V67	4.61	Yes	No	1	5	5
32	R:R:M352	R:R:V67	7.61	No	No	1	4	5
33	R:R:L125	R:R:T68	5.9	No	No	1	6	6
34	R:R:T68	R:R:W130	9.7	No	No	1	6	7
35	R:R:M121	R:R:Y71	8.38	No	Yes	0	7	7
36	R:R:E124	R:R:Y71	5.61	Yes	Yes	1	7	7
37	R:R:L125	R:R:Y71	4.69	No	Yes	1	6	7
38	R:R:I129	R:R:Y71	4.84	Yes	Yes	1	5	7
39	R:R:F75	R:R:T79	7.78	No	No	0	6	6
40	R:R:L114	R:R:T79	4.42	No	No	0	8	6
41	R:R:D113	R:R:N82	4.04	Yes	No	0	9	9
42	R:R:L114	R:R:N82	8.24	No	No	0	8	9
43	R:R:N82	R:R:P366	8.15	No	No	0	9	9
44	R:R:N370	R:R:T85	11.7	No	No	0	7	9
45	R:R:N375	R:R:T88	4.39	No	No	0	7	7
46	R:R:H103	R:R:L89	7.71	No	No	0	8	7
47	R:R:L106	R:R:L89	4.15	Yes	No	0	8	7
48	R:R:T101	R:R:T186	9.42	No	No	0	6	7
49	R:R:R183	R:R:Y104	8.23	No	Yes	0	4	4
50	R:R:T186	R:R:Y104	3.75	No	Yes	0	7	4
51	R:R:I190	R:R:Y104	3.63	No	Yes	0	7	4
52	R:R:E166	R:R:H105	7.39	No	No	0	9	8
53	R:R:F189	R:R:H105	4.53	No	No	0	5	8
54	R:R:L106	R:R:N370	9.61	Yes	No	0	8	7
55	R:R:N159	R:R:S108	10.43	No	No	0	8	9
56	R:R:I190	R:R:S108	4.64	No	No	0	7	9
57	R:R:S108	R:R:W194	6.18	No	Yes	0	9	9
58	R:R:D113	R:R:L109	6.79	Yes	No	0	9	9
59	R:R:L109	R:R:N159	4.12	No	No	0	9	8
60	R:R:L109	R:R:Y369	7.03	No	Yes	0	9	9
61	R:R:S112	R:R:T156	4.8	No	No	0	8	9
62	R:R:S112	R:R:W194	3.71	No	Yes	0	8	9
63	R:R:D113	R:R:T156	4.34	Yes	No	0	9	9
64	R:R:D113	R:R:S362	8.83	Yes	No	0	9	9
65	R:R:D113	R:R:N365	12.12	Yes	No	0	9	9
66	R:R:L114	R:R:L118	8.3	No	No	0	8	5
67	R:R:L115	R:R:L119	4.15	No	No	0	6	5
68	R:R:C152	R:R:L115	4.76	No	No	0	7	6
69	R:R:C152	R:R:I116	8.18	No	No	0	7	7
70	R:R:L119	R:R:L148	6.92	No	No	0	5	5
71	R:R:A120	R:R:R149	4.15	No	Yes	0	6	7
72	R:R:M121	R:R:Y359	10.78	No	No	0	7	7
73	R:R:V123	R:R:Y145	11.36	No	Yes	0	5	6
74	R:R:E124	R:R:F128	8.16	Yes	Yes	1	7	6
75	R:R:E124	R:R:I129	8.2	Yes	Yes	1	7	5
76	R:R:E124	R:R:Y351	12.35	Yes	Yes	1	7	4
77	R:R:E124	R:R:N355	13.15	Yes	Yes	1	7	6
78	R:R:L125	R:R:W130	4.56	No	No	1	6	7
79	R:R:N127	R:R:Y126	10.47	No	No	0	5	4
80	R:R:V131	R:R:Y126	11.36	No	No	0	5	4
81	R:R:A136	R:R:Y126	5.34	No	No	0	4	4
82	R:R:N127	R:R:W135	16.95	No	Yes	1	5	9
83	R:R:F137	R:R:N127	6.04	No	No	1	7	5
84	R:R:F128	R:R:W135	5.01	Yes	Yes	1	6	9
85	R:R:F128	R:R:Y145	6.19	Yes	Yes	1	6	6
86	R:R:F128	R:R:Y146	6.19	Yes	Yes	1	6	5
87	R:R:F128	R:R:Y351	8.25	Yes	Yes	1	6	4
88	R:R:I129	R:R:M352	5.83	Yes	No	1	5	4
89	R:R:G221	R:R:P134	6.09	No	No	0	4	5
90	R:R:F137	R:R:W135	4.01	No	Yes	1	7	9
91	R:R:C142	R:R:W135	5.22	No	Yes	1	9	9
92	R:R:L210	R:R:W135	5.69	No	Yes	0	5	9
93	R:R:C225	R:R:W135	20.89	No	Yes	1	9	9
94	R:R:D139	R:R:R143	11.91	No	No	0	3	7
95	R:R:D139	R:R:L210	4.07	No	No	0	3	5
96	R:R:C142	R:R:C225	7.28	No	No	1	9	9
97	R:R:Y145	R:R:Y146	6.95	Yes	Yes	1	6	5
98	R:R:R149	R:R:Y145	8.23	Yes	Yes	1	7	6
99	R:R:M208	R:R:Y146	20.35	No	Yes	0	5	5
100	R:R:F147	R:R:L148	3.65	Yes	No	0	5	5
101	R:R:A201	R:R:F147	5.55	No	Yes	0	7	5
102	R:R:F147	R:R:I202	3.77	Yes	Yes	0	5	4
103	R:R:F147	R:R:L205	7.31	Yes	No	0	5	5
104	R:R:R149	R:R:Y324	7.2	Yes	Yes	0	7	5
105	R:R:N355	R:R:R149	4.82	Yes	Yes	1	6	7
106	R:R:R149	R:R:Y359	10.29	Yes	No	1	7	7
107	R:R:D150	R:R:M204	9.7	No	No	0	6	6
108	R:R:D150	R:R:N241	5.39	No	Yes	0	6	5
109	R:R:T153	R:R:W321	6.06	No	Yes	4	7	8
110	R:R:F358	R:R:T153	7.78	No	No	4	7	7
111	R:R:L200	R:R:Y154	12.89	No	No	0	5	6
112	R:R:N241	R:R:Y154	11.63	Yes	No	3	5	6
113	R:R:S245	R:R:Y154	5.09	No	No	3	6	6
114	R:R:A155	R:R:W194	5.19	No	Yes	0	7	9
115	R:R:T156	R:R:W321	4.85	No	Yes	0	9	8
116	R:R:A157	R:R:P249	3.74	No	No	0	7	9
117	R:R:I193	R:R:L158	5.71	Yes	No	0	8	7
118	R:R:I193	R:R:N159	5.66	Yes	No	0	8	8
119	R:R:I253	R:R:V160	4.61	No	No	0	8	8
120	R:R:V160	R:R:Y369	5.05	No	Yes	0	8	9
121	R:R:F189	R:R:S162	11.89	No	No	2	5	7
122	R:R:I193	R:R:S162	4.64	Yes	No	2	8	7
123	R:R:I253	R:R:S164	6.19	No	No	0	8	9
124	R:R:N257	R:R:S164	5.96	No	No	0	9	9
125	R:R:R167	R:R:Y369	5.14	No	Yes	0	9	9
126	R:R:C172	R:R:Y168	9.41	No	Yes	5	7	8
127	R:R:H173	R:R:Y168	6.53	Yes	Yes	5	6	8
128	R:R:L256	R:R:Y168	8.21	No	Yes	0	7	8
129	R:R:V259	R:R:Y168	5.05	No	Yes	0	5	8
130	R:R:I260	R:R:Y168	3.63	No	Yes	0	8	8
131	R:R:I171	R:R:I260	4.42	No	No	0	8	8
132	R:R:C172	R:R:H173	4.42	No	Yes	5	7	6
133	R:R:H173	R:R:K176	3.93	Yes	No	0	6	5
134	R:R:R185	R:R:S182	3.95	No	No	0	6	7
135	R:R:F189	R:R:I193	7.54	No	Yes	2	5	8
136	R:R:L195	R:R:L199	5.54	No	No	0	3	4
137	R:R:M204	R:R:M208	4.33	No	No	0	6	5
138	R:R:M208	R:R:P227	8.39	No	No	0	5	5
139	R:R:G209	R:R:I228	5.29	No	No	0	3	3
140	R:R:L210	R:R:L223	15.22	No	No	0	5	3
141	R:R:Q211	R:R:R213	5.84	No	Yes	0	3	2
142	R:R:N212	R:R:T218	5.85	No	No	0	2	2
143	R:R:L223	R:R:N212	9.61	No	No	0	3	2
144	R:R:R213	R:R:V224	3.92	Yes	No	0	2	5
145	R:R:R213	R:R:T226	15.52	Yes	No	0	2	3
146	R:R:G222	R:R:S214	3.71	No	No	0	2	4
147	R:R:H219	R:R:P220	12.2	No	No	0	3	3
148	R:R:P227	R:R:T226	6.99	No	No	0	5	3
149	R:R:T233	R:R:V229	4.76	No	No	0	4	5
150	R:R:D230	R:R:T233	4.34	No	No	0	4	4
151	R:R:K235	R:R:Y333	14.33	No	No	0	4	5
152	R:R:C332	R:R:I238	6.55	No	No	0	4	5
153	R:R:Q239	R:R:Y333	6.76	No	No	0	6	5
154	R:R:N241	R:R:S245	4.47	Yes	No	3	5	6
155	R:R:N241	R:R:R328	15.67	Yes	No	0	5	6
156	R:R:H325	R:R:T242	4.11	Yes	No	0	7	5
157	R:R:L329	R:R:T242	4.42	No	No	0	5	5
158	R:R:F243	R:R:M244	3.73	No	No	0	4	4
159	R:R:H325	R:R:S245	8.37	Yes	No	0	7	6
160	R:R:F246	R:R:L247	3.65	Yes	No	0	8	5
161	R:R:F246	R:R:M250	4.98	Yes	No	0	8	7
162	R:R:F246	R:R:L322	7.31	Yes	No	0	8	6
163	R:R:F246	R:R:H325	6.79	Yes	Yes	0	8	7
164	R:R:F248	R:R:P249	4.33	No	No	0	5	9
165	R:R:F248	R:R:V252	3.93	No	No	0	5	5
166	R:R:F317	R:R:P249	4.33	No	No	0	9	9
167	R:R:M250	R:R:V318	4.56	No	No	0	7	6
168	R:R:F317	R:R:I253	7.54	No	No	0	9	8
169	R:R:L310	R:R:N257	8.24	No	No	0	8	9
170	R:R:N257	R:R:V314	4.43	No	No	0	9	8
171	R:R:H305	R:R:V309	4.15	No	No	0	8	8
172	R:R:R311	R:R:V307	5.23	No	Yes	0	5	7
173	R:R:V313	R:R:Y369	8.83	No	Yes	0	8	9
174	R:R:F317	R:R:W321	7.02	No	Yes	0	9	8
175	R:R:C320	R:R:S361	5.16	No	No	0	8	9
176	R:R:F358	R:R:W321	14.03	No	Yes	4	7	8
177	R:R:S361	R:R:W321	6.18	No	Yes	0	9	8
178	R:R:H325	R:R:Y324	6.53	Yes	Yes	0	7	5
179	R:R:R327	R:R:Y324	8.23	Yes	Yes	0	5	5
180	R:R:R328	R:R:Y324	5.14	No	Yes	0	6	5
181	R:R:F358	R:R:Y324	8.25	No	Yes	0	7	5
182	R:R:R327	R:R:Y347	12.35	Yes	Yes	1	5	4
183	R:R:F350	R:R:R327	5.34	Yes	Yes	1	5	5
184	R:R:R327	R:R:Y351	15.43	Yes	Yes	1	5	4
185	R:R:R327	R:R:T354	9.06	Yes	No	1	5	5
186	R:R:L329	R:R:Y333	5.86	No	No	0	5	5
187	R:R:F331	R:R:Y347	5.16	No	Yes	0	3	4
188	R:R:I334	R:R:Q338	5.49	No	No	0	3	1
189	R:R:I334	R:R:W339	11.74	No	Yes	0	3	7
190	R:R:D336	R:R:E337	10.39	No	No	0	2	2
191	R:R:L343	R:R:W339	13.67	No	Yes	0	2	7
192	R:R:W339	R:R:Y347	4.82	Yes	Yes	1	7	4
193	R:R:F344	R:R:H348	10.18	Yes	Yes	1	3	4
194	R:R:H348	R:R:Y347	8.71	Yes	Yes	1	4	4
195	R:R:F350	R:R:T354	7.78	Yes	No	1	5	5
196	R:R:N355	R:R:Y351	19.77	Yes	Yes	1	6	4
197	R:R:N355	R:R:Y359	4.65	Yes	No	1	6	7
198	R:R:N365	R:R:S361	4.47	No	No	0	9	9
199	R:R:N365	R:R:Y369	4.65	No	Yes	0	9	9
200	R:R:L163	R:R:Y369	3.52	No	Yes	0	9	9
201	R:R:P323	R:R:T354	3.5	No	No	0	9	5
202	R:R:A155	R:R:S197	3.42	No	No	0	7	8
203	R:R:C332	R:R:V234	3.42	No	No	0	4	5
204	R:R:A161	R:R:V252	3.39	No	No	0	7	5
205	R:R:I202	R:R:P203	3.39	Yes	No	0	4	8
206	R:R:A110	R:R:T85	3.36	No	No	0	9	9
207	R:R:M121	R:R:P122	3.35	No	No	0	7	9
208	R:R:C172	R:R:K263	3.23	No	No	0	7	5
209	R:R:T207	R:R:V237	3.17	No	No	0	4	7
210	R:R:T265	R:R:V307	3.17	No	Yes	0	5	7
211	R:R:A360	R:R:L74	3.15	No	No	0	6	7
212	R:R:A110	R:R:L86	3.15	No	No	0	9	7
213	R:R:A312	R:R:L368	3.15	No	Yes	0	6	8
214	R:R:I116	R:R:S362	3.1	No	No	0	7	9
215	R:R:A232	R:R:D230	3.09	No	No	0	3	4
216	R:R:L117	R:R:S362	3	No	No	0	6	9
217	R:R:L256	R:R:S164	3	No	No	0	7	9
218	R:R:L106	R:R:V102	2.98	Yes	No	0	8	8
219	R:R:L256	R:R:V165	2.98	No	No	0	7	6
220	R:R:L264	R:R:V307	2.98	No	Yes	0	8	7
221	R:R:L322	R:R:V326	2.98	No	No	0	6	5
222	R:R:L72	R:R:T68	2.95	No	No	0	3	6
223	R:R:L180	R:R:T179	2.95	No	No	0	5	4
224	R:R:D54	R:R:S53	2.94	No	No	0	4	5
225	R:R:N262	R:R:T258	2.92	No	No	0	5	1
226	R:R:I334	R:R:M330	2.92	No	No	0	3	5
227	R:R:I61	R:R:K64	2.91	No	No	0	3	5
228	R:R:D230	R:R:T231	2.89	No	No	0	4	1
229	R:R:K187	R:R:K188	2.87	No	No	0	4	3
230	L:L:L13	R:R:I238	2.85	Yes	No	0	0	5
231	R:R:I70	R:R:L74	2.85	No	No	0	4	7
232	R:R:I238	R:R:L329	2.85	No	No	0	5	5
233	R:R:I260	R:R:L264	2.85	No	No	0	8	8
234	R:R:I364	R:R:L368	2.85	No	Yes	0	6	8
235	R:R:I367	R:R:L371	2.85	No	No	0	7	5
236	R:R:G138	R:R:W135	2.81	No	Yes	0	8	9
237	R:R:H305	R:R:S373	2.79	No	No	0	8	8
238	R:R:H305	R:R:V372	2.77	No	No	0	8	7
239	R:R:I228	R:R:Q211	2.74	No	No	0	3	3
240	R:R:D345	R:R:N58	2.69	No	No	0	3	3
241	R:R:A356	R:R:Y71	2.67	No	Yes	0	5	7
242	R:R:S63	R:R:Y349	2.54	No	No	0	2	1
243	R:R:F206	R:R:I202	2.51	No	Yes	0	4	4
244	R:R:F243	R:R:L247	2.44	No	No	0	4	5
245	R:R:F350	R:R:L353	2.44	Yes	No	0	5	5
246	R:R:F376	R:R:N375	2.42	No	No	0	9	7
247	R:R:D345	R:R:F344	2.39	No	Yes	0	3	3
248	R:R:L106	R:R:Y369	2.34	Yes	Yes	0	8	9
249	R:R:L111	R:R:W194	2.28	No	Yes	0	6	9
250	R:R:F346	R:R:F350	2.14	No	Yes	0	4	5
251	R:R:A110	R:R:G107	1.95	No	No	0	9	5
252	R:R:A140	R:R:G141	1.95	No	No	0	1	4
253	R:R:G78	R:R:V77	1.84	No	No	0	8	5
254	R:R:G81	R:R:V80	1.84	No	No	0	8	4
255	R:R:G306	R:R:V309	1.84	No	No	0	8	8
256	R:R:A151	R:R:A201	1.79	No	No	0	5	7
257	R:R:P203	R:R:V237	1.77	No	No	0	8	7
258	R:R:G222	R:R:L55	1.71	No	No	0	2	2
259	R:R:G78	R:R:L117	1.71	No	No	0	8	6
260	R:R:G144	R:R:L205	1.71	No	No	0	4	5
261	R:R:C320	R:R:V319	1.71	No	No	0	8	5
262	R:R:A261	R:R:V307	1.7	No	Yes	0	6	7
263	R:R:L357	R:R:P323	1.64	No	No	0	7	9
264	R:R:A356	R:R:I70	1.62	No	No	0	5	4
265	R:R:V76	R:R:V77	1.6	No	No	0	5	5
266	R:R:V80	R:R:V84	1.6	No	No	0	4	6
267	R:R:S100	R:R:T101	1.6	No	No	0	7	6
268	R:R:V229	R:R:V234	1.6	No	No	0	5	5
269	R:R:V236	R:R:V240	1.6	No	No	0	4	4
270	R:R:S254	R:R:T258	1.6	No	No	0	5	1
271	R:R:V309	R:R:V313	1.6	No	No	0	8	8
272	R:R:T88	R:R:V84	1.59	No	No	0	7	6
273	R:R:A363	R:R:L74	1.58	No	No	0	6	7
274	R:R:A196	R:R:L158	1.58	No	No	0	5	7
275	R:R:A177	R:R:L169	1.58	No	No	0	6	4
276	R:R:A316	R:R:L368	1.58	No	Yes	0	5	8
277	R:R:I61	R:R:V65	1.54	No	No	0	3	5
278	R:R:A140	R:R:D139	1.54	No	No	0	1	3
279	R:R:I255	R:R:V259	1.54	No	No	0	4	5
280	R:R:I315	R:R:V319	1.54	No	No	0	5	5
281	R:R:I367	R:R:V372	1.54	No	No	0	7	7
282	R:R:H173	R:R:P174	1.53	Yes	No	0	6	9
283	R:R:M181	R:R:T101	1.51	No	No	0	6	6
284	R:R:L368	R:R:V372	1.49	Yes	No	0	8	7
285	R:R:D336	R:R:S335	1.47	No	No	0	2	3
286	R:R:L343	R:R:T340	1.47	No	No	0	2	7
287	R:R:K178	R:R:M181	1.44	No	No	0	4	6
288	R:R:I202	R:R:L199	1.43	Yes	No	0	4	4
289	R:R:N370	R:R:N375	1.36	No	No	0	7	7
290	R:R:F342	R:R:T340	1.3	No	No	0	3	7
291	R:R:D56	R:R:H133	1.26	No	No	0	2	5
292	R:R:K187	R:R:Y104	1.19	No	Yes	0	4	4
293	R:R:L169	R:R:Y168	1.17	No	Yes	0	4	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:P10	8.7725	4	1	0
2	L:L:Y11	5.485	4	0	0
3	L:L:L13	4.9	5	0	0
4	R:R:V57	12.2775	4	1	2
5	R:R:Y71	5.62667	6	1	7
6	R:R:Y104	4.2	4	0	4
7	R:R:L106	4.77	4	0	8
8	R:R:D113	7.224	5	0	9
9	R:R:E124	9.494	5	1	7
10	R:R:F128	6.89	6	1	6
11	R:R:I129	5.87	4	1	5
12	R:R:W135	8.65429	7	1	9
13	R:R:Y145	8.1825	4	1	6
14	R:R:Y146	9.8375	4	1	5
15	R:R:F147	5.07	4	0	5
16	R:R:R149	6.938	5	1	7
17	R:R:Y168	5.66667	6	5	8
18	R:R:H173	4.1025	4	5	6
19	R:R:I193	5.8875	4	2	8
20	R:R:W194	4.34	4	0	9
21	R:R:I202	2.775	4	0	4
22	R:R:R213	7.23	4	0	2
23	R:R:N241	9.29	4	3	5
24	R:R:F246	5.6825	4	0	8
25	R:R:V307	3.27	4	0	7
26	R:R:W321	7.628	5	4	8
27	R:R:Y324	7.07	5	0	5
28	R:R:H325	6.45	4	0	7
29	R:R:R327	9.00833	6	1	5
30	R:R:W339	10.278	5	1	7
31	R:R:F344	9.876	5	1	3
32	R:R:Y347	8.434	5	1	4
33	R:R:H348	11.4025	4	1	4
34	R:R:F350	4.425	4	1	5
35	R:R:Y351	11.886	5	1	4
36	R:R:N355	10.5975	4	1	6
37	R:R:L368	2.2675	4	0	8
38	R:R:Y369	5.22286	7	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:I12	L:L:Y11	18.5126	3.63	No	Yes	0	0	0
2	L:L:Y11	R:R:L55	12.8236	8.21	Yes	No	0	0	2
3	R:R:R327	R:R:Y347	20.5446	12.35	Yes	Yes	1	5	4
4	R:R:R327	R:R:Y351	39.1244	15.43	Yes	Yes	1	5	4
5	L:L:I12	R:R:Y351	13.989	3.63	No	Yes	1	0	4
6	L:L:L13	R:R:R327	12.1325	3.64	Yes	Yes	0	0	5
7	R:R:R327	R:R:Y324	56.2885	8.23	Yes	Yes	0	5	5
8	R:R:R328	R:R:Y324	11.6096	5.14	No	Yes	0	6	5
9	R:R:E124	R:R:Y351	19.2335	12.35	Yes	Yes	1	7	4
10	R:R:E124	R:R:Y71	31.9114	5.61	Yes	Yes	1	7	7
11	R:R:L125	R:R:Y71	26.5773	4.69	No	Yes	1	6	7
12	R:R:L125	R:R:W130	19.9656	4.56	No	No	1	6	7
13	R:R:K64	R:R:W130	17.8365	11.6	No	No	0	5	7
14	R:R:R149	R:R:Y324	38.6538	7.2	Yes	Yes	0	7	5
15	R:R:R149	R:R:Y359	12.7153	10.29	Yes	No	1	7	7
16	R:R:M121	R:R:Y359	12.45	10.78	No	No	0	7	7
17	R:R:M121	R:R:Y71	11.434	8.38	No	Yes	0	7	7
18	R:R:F358	R:R:Y324	100	8.25	No	Yes	0	7	5
19	R:R:F358	R:R:W321	98.8271	14.03	No	Yes	4	7	8
20	R:R:T156	R:R:W321	49.8674	4.85	No	Yes	0	9	8
21	R:R:D113	R:R:T156	35.9083	4.34	Yes	No	0	9	9
22	R:R:S361	R:R:W321	29.0389	6.18	No	Yes	0	9	8
23	R:R:N365	R:R:S361	26.5436	4.47	No	No	0	9	9
24	R:R:N365	R:R:Y369	31.3884	4.65	No	Yes	0	9	9
25	R:R:L106	R:R:Y369	19.7042	2.34	Yes	Yes	0	8	9
26	R:R:L106	R:R:N370	14.7436	9.61	Yes	No	0	8	7
27	R:R:S112	R:R:T156	15.0275	4.8	No	No	0	8	9
28	R:R:S112	R:R:W194	13.806	3.71	No	Yes	0	8	9
29	R:R:S108	R:R:W194	10.2798	6.18	No	Yes	0	9	9
30	R:R:I190	R:R:S108	12.6181	4.64	No	No	0	7	9
31	R:R:I190	R:R:Y104	11.378	3.63	No	Yes	0	7	4
32	R:R:D113	R:R:L109	16.3124	6.79	Yes	No	0	9	9
33	R:R:L109	R:R:N159	14.0749	4.12	No	No	0	9	8
34	R:R:D113	R:R:S362	32.7855	8.83	Yes	No	0	9	9
35	R:R:I116	R:R:S362	25.6509	3.1	No	No	0	7	9
36	R:R:C152	R:R:I116	24.2016	8.18	No	No	0	7	7
37	R:R:C152	R:R:L115	22.7448	4.76	No	No	0	7	6
38	R:R:L115	R:R:L119	21.2805	4.15	No	No	0	6	5
39	R:R:L119	R:R:L148	19.8087	6.92	No	No	0	5	5
40	R:R:F128	R:R:W135	23.574	5.01	Yes	Yes	1	6	9
41	R:R:L210	R:R:W135	11.4639	5.69	No	Yes	0	5	9
42	R:R:F147	R:R:L148	18.3295	3.65	Yes	No	0	5	5
43	R:R:F147	R:R:I202	10.8214	3.77	Yes	Yes	0	5	4
44	R:R:H325	R:R:Y324	16.092	6.53	Yes	Yes	0	7	5
45	R:R:F317	R:R:W321	30.2043	7.02	No	Yes	0	9	8
46	R:R:F317	R:R:I253	25.3334	7.54	No	No	0	9	8
47	R:R:I253	R:R:V160	11.5423	4.61	No	No	0	8	8
48	R:R:I253	R:R:S164	32.1766	6.19	No	No	0	8	9
49	R:R:L256	R:R:S164	26.8201	3	No	No	0	7	9
50	R:R:L256	R:R:Y168	24.1007	8.21	No	Yes	0	7	8
51	R:R:I260	R:R:Y168	10.164	3.63	No	Yes	0	8	8
52	L:L:L13	R:R:I238	15.5355	2.85	Yes	No	0	0	5
53	R:R:C332	R:R:I238	11.815	6.55	No	No	0	4	5
54	R:R:C332	R:R:V234	10.149	3.42	No	No	0	4	5
55	R:R:V313	R:R:Y369	16.0435	8.83	No	Yes	0	8	9
56	R:R:V309	R:R:V313	14.8631	1.6	No	No	0	8	8
57	R:R:H305	R:R:V309	12.2259	4.15	No	No	0	8	8
58	R:R:A356	R:R:Y71	11.2024	2.67	No	Yes	0	5	7
59	R:R:F128	R:R:Y351	10.4665	8.25	Yes	Yes	1	6	4
60	R:R:R149	R:R:Y145	12.8908	8.23	Yes	Yes	1	7	6
61	R:R:N355	R:R:R149	13.0701	4.82	Yes	Yes	1	6	7
62	R:R:E124	R:R:N355	12.5509	13.15	Yes	Yes	1	7	6
63	R:R:L109	R:R:Y369	11.2585	7.03	No	Yes	0	9	9
64	R:R:V160	R:R:Y369	11.0194	5.05	No	Yes	0	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:R8	R:R:F344	25.66	0	No	Yes	0	3	0	1
L:L:R9	R:R:W339	9	0	No	Yes	0	7	0	1
L:L:P10	R:R:W339	12.16	1	Yes	Yes	0	7	0	1
L:L:P10	R:R:F344	7.22	1	Yes	Yes	0	3	0	1
L:L:P10	R:R:Y347	11.13	1	Yes	Yes	0	4	0	1
L:L:P10	R:R:H348	4.58	1	Yes	Yes	0	4	0	1
L:L:Y11	R:R:L55	8.21	0	Yes	No	0	2	0	1
L:L:Y11	R:R:V57	5.05	0	Yes	Yes	0	2	0	1
L:L:Y11	R:R:V224	5.05	0	Yes	No	0	5	0	1
L:L:I12	R:R:F128	7.54	1	No	Yes	0	6	0	1
L:L:I12	R:R:Y351	3.63	1	No	Yes	0	4	0	1
L:L:L13	R:R:Y146	5.86	0	Yes	Yes	0	5	0	1
L:L:L13	R:R:R327	3.64	0	Yes	Yes	0	5	0	1
L:L:L13	R:R:R328	8.5	0	Yes	No	0	6	0	1
L:L:L13	R:R:F331	3.65	0	Yes	No	0	3	0	1
R:R:L55	R:R:R213	3.64	0	No	Yes	2	2	1	2
R:R:H132	R:R:V57	17.99	0	No	Yes	5	2	2	1
R:R:F344	R:R:V57	3.93	1	Yes	Yes	3	2	1	1
R:R:H348	R:R:V57	22.14	1	Yes	Yes	4	2	1	1
R:R:E124	R:R:F128	8.16	1	Yes	Yes	7	6	2	1
R:R:E124	R:R:Y351	12.35	1	Yes	Yes	7	4	2	1
R:R:E124	R:R:N355	13.15	1	Yes	Yes	7	6	2	2
R:R:F128	R:R:W135	5.01	1	Yes	Yes	6	9	1	2
R:R:F128	R:R:Y145	6.19	1	Yes	Yes	6	6	1	2
R:R:F128	R:R:Y146	6.19	1	Yes	Yes	6	5	1	1
R:R:F128	R:R:Y351	8.25	1	Yes	Yes	6	4	1	1
R:R:Y145	R:R:Y146	6.95	1	Yes	Yes	6	5	2	1
R:R:M208	R:R:Y146	20.35	0	No	Yes	5	5	2	1
R:R:R213	R:R:V224	3.92	0	Yes	No	2	5	2	1
R:R:C332	R:R:I238	6.55	0	No	No	4	5	2	1
R:R:N241	R:R:R328	15.67	3	Yes	No	5	6	2	1
R:R:R327	R:R:Y324	8.23	1	Yes	Yes	5	5	1	2
R:R:R328	R:R:Y324	5.14	0	No	Yes	6	5	1	2
R:R:R327	R:R:Y347	12.35	1	Yes	Yes	5	4	1	1
R:R:F350	R:R:R327	5.34	1	Yes	Yes	5	5	2	1
R:R:R327	R:R:Y351	15.43	1	Yes	Yes	5	4	1	1
R:R:R327	R:R:T354	9.06	1	Yes	No	5	5	1	2
R:R:F331	R:R:Y347	5.16	0	No	Yes	3	4	1	1
R:R:I334	R:R:W339	11.74	0	No	Yes	3	7	2	1
R:R:L343	R:R:W339	13.67	0	No	Yes	2	7	2	1
R:R:W339	R:R:Y347	4.82	1	Yes	Yes	7	4	1	1
R:R:F344	R:R:H348	10.18	1	Yes	Yes	3	4	1	1
R:R:H348	R:R:Y347	8.71	1	Yes	Yes	4	4	1	1
R:R:F350	R:R:T354	7.78	1	Yes	No	5	5	2	2
R:R:N355	R:R:Y351	19.77	1	Yes	Yes	6	4	2	1
L:L:L13	R:R:I238	2.85	0	Yes	No	0	5	0	1
R:R:I238	R:R:L329	2.85	0	No	No	5	5	1	2
R:R:D345	R:R:F344	2.39	0	No	Yes	3	3	2	1
R:R:G222	R:R:L55	1.71	0	No	No	2	2	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8FMZ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.63
Number of Linked Nodes	264
Number of Links	293
Number of Hubs	38
Number of Links mediated by Hubs	140
Number of Communities	5
Number of Nodes involved in Communities	42
Number of Links involved in Communities	58

Path Summary
Number Of Nodes in MetaPath	65
Number Of Links MetaPath	64
Number of Shortest Paths	49995
Length Of Smallest Path	3
Average Path Length	12.3246
Length of Longest Path	26
Minimum Path Strength	1.375
Average Path Strength	6.67892
Maximum Path Strength	20.065
Minimum Path Correlation	0.7
Average Path Correlation	0.914704
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.26316
Average % Of Corr. Nodes	53.5409
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.8601
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P20789
Sequence	>8FMZ_nogp_Chain_R N S D L D V N T D I Y S K V L V T A I Y L A L F V V G T V G N S V T L F T L A S T V H Y H L G S L A L S D L L I L L L A M P V E L Y N F I W V H H P W A F G D A G C R G Y Y F L R D A C T Y A T A L N V A S L S V E R Y L A I C H P F K A K T L M S R S R T K K F I S A I W L A S A L L A I P M L F T M G L Q N R S A G T H P G G L V C T P I V D T A T V K V V I Q V N T F M S F L F P M L V I S I L N T V I A N K L T V M L R H G V L V L R A V V I A F V V C W L P Y H V R R L M F C Y I S D E Q W T T F L F D F Y H Y F Y M L T N A L F Y A S S A I N P I L Y N L V S A N F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JPF	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin	PubChem 118610427	-	3.02	2023-08-09	10.1038/s41586-023-06395-9
	8JPC	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin-(8-13)	PubChem 118610427; GDP; Mg	Gq; GRK2	3.07	2023-08-09	10.1038/s41586-023-06395-9
	8JPC (No Gprot)	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin-(8-13)	PubChem 118610427; GDP; Mg		3.07	2023-08-09	10.1038/s41586-023-06395-9
	8JPB	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin-(8-13)	PubChem 118610427; GDP; Mg	Gq; GRK2	3.07	2023-08-09	10.1038/s41586-023-06395-9
	8JPB (No Gprot)	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin-(8-13)	PubChem 118610427; GDP; Mg		3.07	2023-08-09	10.1038/s41586-023-06395-9
	8FN1	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	-	chim(NtGi1-Go)/β1/γ2	2.88	2023-03-29	10.1021/acs.biochem.3c00029
	8FN1 (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	-		2.88	2023-03-29	10.1021/acs.biochem.3c00029
	8FN0	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	PubChem 118610427	chim(NtGi1-Go)/β1/γ2	2.89	2023-03-29	10.1021/acs.biochem.3c00029
	8FN0 (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	PubChem 118610427		2.89	2023-03-29	10.1021/acs.biochem.3c00029
	8FMZ	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.59	2023-03-29	10.1021/acs.biochem.3c00029
	8FMZ (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	-		2.59	2023-03-29	10.1021/acs.biochem.3c00029
	7UL2	A	Peptide	Neurotensin	NTS₁	Homo sapiens	SR48692	Na	-	2.4	2022-06-29	10.1038/s41594-022-00859-8
	6ZIN	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	SR48692	-	-	2.64	2021-02-10	10.1126/sciadv.abe5504
	6ZA8	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	RTI-3a	-	-	2.72	2021-02-10	10.1126/sciadv.abe5504
	6Z8N	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	SRI-9829	-	-	2.8	2021-02-10	10.1126/sciadv.abe5504
	6Z66	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	-	-	-	3.19	2021-02-10	10.1126/sciadv.abe5504
	6Z4V	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	NTS8-13	-	-	2.6	2021-02-10	10.1126/sciadv.abe5504
	6Z4S	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	SR48692	-	-	2.71	2021-02-10	10.1126/sciadv.abe5504
	6Z4Q	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	SR142948A	-	-	2.92	2021-02-10	10.1126/sciadv.abe5504
	6YVR	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	NTS8-13	-	-	2.46	2021-02-10	10.1126/sciadv.abe5504
	7L0S	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	Gi1/β1/γ1	4.5	2021-01-06	10.1038/s41594-020-00554-6
	7L0S (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-		4.5	2021-01-06	10.1038/s41594-020-00554-6
	7L0R	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	Gi1/β1/γ1	4.2	2021-01-06	10.1038/s41594-020-00554-6
	7L0R (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-		4.2	2021-01-06	10.1038/s41594-020-00554-6
	7L0Q	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	Gi1/β1/γ1	4.3	2021-01-06	10.1038/s41594-020-00554-6
	7L0Q (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-		4.3	2021-01-06	10.1038/s41594-020-00554-6
	7L0P	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	Gi1/β1/γ1	4.1	2021-01-06	10.1038/s41594-020-00554-6
	7L0P (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-		4.1	2021-01-06	10.1038/s41594-020-00554-6
	6UP7	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin	-	Arrestin2	4.2	2020-02-26	10.1038/s41586-020-1953-1
	6PWC	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin	-	Arrestin2	4.9	2019-12-04	10.1038/s41422-019-0256-2
	6OSA	A	Peptide	Neurotensin	NTS₁	Homo sapiens	JMV449	-	Gi1/β1/γ2	3	2019-07-10	10.1038/s41586-019-1337-6
	6OSA (No Gprot)	A	Peptide	Neurotensin	NTS₁	Homo sapiens	JMV449	-		3	2019-07-10	10.1038/s41586-019-1337-6
	6OS9	A	Peptide	Neurotensin	NTS₁	Homo sapiens	JMV449	-	Gi1/β1/γ2	3	2019-07-10	10.1038/s41586-019-1337-6
	6OS9 (No Gprot)	A	Peptide	Neurotensin	NTS₁	Homo sapiens	JMV449	-		3	2019-07-10	10.1038/s41586-019-1337-6
	5T04	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	3.3	2016-12-21	10.1038/srep38564
	4XES	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	2.6	2015-07-29	10.1038/ncomms8895
	4XEE	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	2.9	2015-07-29	10.1038/ncomms8895
	4BWB	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	3.57	2014-01-29	10.1073/pnas.1317903111
	4BV0	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	3.1	2014-01-29	10.1073/pnas.1317903111
	4BUO	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	2.75	2014-01-29	10.1073/pnas.1317903111
	3ZEV	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	3	2014-01-29	10.1073/pnas.1317903111
	4GRV	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin-(8-13)	-	-	2.8	2012-10-17	10.1038/nature11558

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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