Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:Y70 9.82627
2R:R:F74 8.04714727
3R:R:N81 7.598529
4R:R:H102 7.225478
5R:R:H104 4.166508
6R:R:D112 5.90167629
7R:R:L116 8.07167627
8R:R:M120 15.536528
9R:R:E123 16.3875426
10R:R:F127 10.5625404
11R:R:Y145 7.324524
12R:R:F146 11.052526
13R:R:R148 9.55333627
14R:R:T152 7.146527
15R:R:V159 5.1825498
16R:R:R166 7.146509
17R:R:Y167 8.278508
18R:R:M207 5.835426
19R:R:I237 4.6175426
20R:R:Q238 7.6925425
21R:R:S244 5.0425426
22R:R:F245 12.29528
23R:R:L255 6.805407
24R:R:I259 6.69254109
25R:R:L263 4.54108
26R:R:L305 4.7375408
27R:R:F312 4.265629
28R:R:W316 8.13833628
29R:R:Y319 6.378526
30R:R:H320 17.095427
31R:R:C327 4.7575423
32R:R:Y342 12.866504
33R:R:Y346 8.59424
34R:R:M347 9.3175423
35R:R:N350 9.915426
36R:R:F353 9.444527
37R:R:Y354 9.1711027
38R:R:S357 5.498529
39R:R:T358 6.49427
40R:R:I359 4.8925406
41R:R:N360 3.456509
42R:R:P361 6.215429
43R:R:Y364 5.5325499
44R:R:N370 6.70254117
45R:R:F375 8.498507
46R:R:?407 7.02833617
47R:R:?409 11.3225416
48R:R:?410 9.384516
49V:V:K10 8.2925419
50V:V:S13 6.4825488
51V:V:N15 8.3588
52V:V:V20 3.975416
53V:V:Y21 7.19167618
54V:V:D26 10.6825469
55V:V:D29 7.1575419
56V:V:D38 7.4825407
57V:V:V40 5.4475418
58V:V:V55 6.992518
59V:V:T56 5.4625457
60V:V:L57 5.415417
61V:V:F61 5.40571709
62V:V:Y63 7.65254129
63V:V:R65 9.2275407
64V:V:L79 7.138518
65V:V:F80 7.865414
66V:V:P88 4.23409
67V:V:Q101 9.045619
68V:V:L104 5.935419
69V:V:L108 5.975418
70V:V:F115 7.335419
71V:V:F117 8.226518
72V:V:I119 4.2075415
73V:V:N122 5.455405
74V:V:P124 5.126519
75V:V:Q130 4.99409
76V:V:K147 10.5557
77V:V:F149 5.84455
78V:V:C150 4.6675405
79V:V:I158 6.9625455
80V:V:N162 8.575488
81V:V:R165 9.6525455
82V:V:L166 5.7275418
83V:V:R169 9.57469
84V:V:K170 9.385419
85V:V:Q172 6.274519
86V:V:Y173 8.15404
87V:V:F190 7.386549
88V:V:L199 6.85754156
89V:V:L203 6.304538
90V:V:I207 5.34145
91V:V:Y208 9.326536
92V:V:H210 12.62439
93V:V:I214 5.138538
94V:V:V220 5.1225446
95V:V:N222 6.914549
96V:V:K226 9.34548
97V:V:V228 3.48448
98V:V:I231 4.29406
99V:V:K232 8.21416
100V:V:I233 7.08405
101V:V:V235 4.7725438
102V:V:R236 6.59415
103V:V:Q237 8.155439
104V:V:Y238 8.09833614
105V:V:D240 6.995416
106V:V:P252 4.11414
107V:V:V253 4.65409
108V:V:V262 5.278547
109V:V:F268 4.814545
110V:V:Y272 4.666544
111V:V:L274 6.52535
112V:V:L289 4.154139
113V:V:T298 5.54254138
114V:V:N299 9.0725438
115V:V:E313 5.945417
116V:V:I317 4.595408
117V:V:I318 5.0175415
118V:V:V319 4.1425438
119V:V:Y321 8.19167639
120V:V:K326 4.0375417
121V:V:L327 6.43407
122V:V:V328 6.684514
123V:V:V329 6.36446
124V:V:F349 7.595437
125V:V:T350 5.92254144
126V:V:M352 3.76408
127V:V:P360 8.175461
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:M347 R:R:N350 23.77117.01YesYes236
2R:R:E123 R:R:N350 12.320521.03YesYes266
3R:R:E123 R:R:Y354 12.760710.1YesYes267
4R:R:I259 V:V:L71 13.04164.28YesNo097
5R:R:I259 R:R:L255 10.22432.85YesYes097
6R:R:F312 R:R:W316 16.4566.01YesYes298
7R:R:N350 R:R:Y319 12.38775.81YesYes266
8R:R:T152 R:R:Y354 15.85589.99YesYes277
9R:R:T152 R:R:T155 31.19234.71YesNo079
10R:R:L108 R:R:T155 36.956110.32NoNo099
11R:R:L108 R:R:N158 37.078912.36NoNo098
12R:R:H104 R:R:N158 37.83225.1YesNo088
13R:R:H104 R:R:T185 38.54744.11YesNo087
14R:R:T100 R:R:T185 38.72719.42NoNo077
15R:R:F353 R:R:T152 13.82225.19YesYes277
16R:R:T100 V:V:R65 38.91413.88NoYes077
17R:R:S357 R:R:Y354 16.82057.63YesYes297
18R:R:N360 R:R:S357 20.4562.98YesYes099
19R:R:N360 R:R:V159 43.67272.96YesYes098
20R:R:L105 R:R:V159 42.75022.98NoYes988
21R:R:L105 R:R:L162 43.23849.69NoNo089
22R:R:L162 R:R:V101 43.431210.43NoNo098
23R:R:R166 R:R:V101 43.62535.23YesNo098
24R:R:R166 V:V:R65 60.478810.66YesYes097
25R:R:F312 R:R:N360 17.15243.62YesYes099
26R:R:M347 R:R:Y346 13.90595.99YesYes234
27R:R:D149 R:R:F146 15.494514.33NoYes056
28R:R:D149 R:R:R148 16.25464.76NoYes057
29R:R:F146 R:R:I237 10.91856.28YesYes266
30R:R:Y342 R:R:Y346 11.96423.97YesYes044
31R:R:?407 V:V:L166 14.22464.55YesYes178
32V:V:A148 V:V:V20 18.60011.7NoYes166
33V:V:A148 V:V:V55 49.79381.7NoYes168
34V:V:F117 V:V:V55 50.7376.55YesYes188
35V:V:F117 V:V:L57 76.935312.18YesYes187
36V:V:F80 V:V:L57 73.45523.65YesYes147
37V:V:F80 V:V:L123 74.21214.87YesNo146
38V:V:L123 V:V:P124 75.73064.93NoYes169
39V:V:L79 V:V:P124 25.44283.28YesYes189
40V:V:F61 V:V:L79 28.765310.96YesYes098
41V:V:F61 V:V:Y63 40.94883.09YesYes099
42V:V:I241 V:V:Y63 40.85336.04NoYes089
43V:V:I241 V:V:Y249 1006.04NoNo087
44V:V:R65 V:V:Y249 99.67692.06YesNo077
45V:V:F115 V:V:F117 25.2065.36YesYes198
46V:V:P124 V:V:V142 24.92897.07YesNo099
47V:V:F61 V:V:V142 25.06273.93YesNo099
48V:V:G316 V:V:P124 24.91874.06NoYes189
49V:V:F61 V:V:G316 28.78264.52YesNo098
50V:V:F61 V:V:I317 42.18585.02YesYes098
51V:V:I241 V:V:I317 59.38082.94NoYes088
52R:R:?407 R:R:L408 10.21314.55YesNo173
53V:V:V164 V:V:V20 10.12176.41NoYes086
54V:V:F115 V:V:G39 15.78263.01YesNo098
55V:V:D38 V:V:G39 15.18735.03YesNo078
56V:V:D38 V:V:Q101 12.83183.92YesYes079
57V:V:A148 V:V:V41 30.64051.7NoNo165
58V:V:V41 V:V:V43 30.27033.21NoNo056
59V:V:I317 V:V:V127 20.19746.14YesNo088
60V:V:A301 V:V:V127 20.08883.39NoNo098
61V:V:A301 V:V:V319 20.0045.09NoYes098
62V:V:D29 V:V:Q172 13.453511.75YesYes199
63V:V:V43 V:V:V53 20.50848.02NoNo067
64V:V:C150 V:V:R51 10.42994.18YesNo056
65V:V:F87 V:V:V53 14.25993.93NoNo047
66V:V:F87 V:V:P88 13.09364.33NoYes049
67V:V:V319 V:V:Y321 14.80573.79YesYes389
68V:V:F349 V:V:Y321 18.376210.32YesYes379
69V:V:F349 V:V:L203 16.29363.65YesYes378
70V:V:F349 V:V:Y208 10.336710.32YesYes376
71V:V:I233 V:V:Y272 11.32827.25YesYes054
72R:R:R166 V:V:L71 16.819513.36YesNo097
73R:R:R148 R:R:Y354 13.975519.55YesYes277
74V:V:I119 V:V:L57 11.76842.85YesYes157
75V:V:M352 V:V:Q172 12.46834.08YesYes089
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 9M0D
Class A
SubFamily Peptide
Type Neurotensin
SubType NTS1
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Arrestin2
PDB Resolution 3.41
Date 2025-04-09
D.O.I. doi.org/10.1038/s41422-025-01095-7
Net Summary
Imin 2.83
Number of Linked Nodes 570
Number of Links 715
Number of Hubs 127
Number of Links mediated by Hubs 434
Number of Communities 16
Number of Nodes involved in Communities 177
Number of Links involved in Communities 255
Path Summary
Number Of Nodes in MetaPath 76
Number Of Links MetaPath 75
Number of Shortest Paths 818137
Length Of Smallest Path 3
Average Path Length 24.7213
Length of Longest Path 46
Minimum Path Strength 1.29
Average Path Strength 6.15564
Maximum Path Strength 22.365
Minimum Path Correlation 0.7
Average Path Correlation 0.96712
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.22581
Average % Of Corr. Nodes 40.6635
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 53.7428
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • cell communication   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • neuropeptide signaling pathway   • adult locomotory behavior   • behavior   • multicellular organismal process   • adult behavior   • locomotory behavior   • system process   • learning   • learning or memory   • nervous system process   • cognition   • regulation of calcium ion transport   • regulation of localization   • intracellular calcium ion homeostasis   • negative regulation of biological process   • negative regulation of transport   • calcium ion transport   • localization   • negative regulation of cation transmembrane transport   • monoatomic cation homeostasis   • monoatomic cation transport   • intracellular monoatomic ion homeostasis   • regulation of release of sequestered calcium ion into cytosol   • regulation of monoatomic ion transport   • establishment of localization   • maintenance of location   • transmembrane transport   • release of sequestered calcium ion into cytosol   • regulation of transmembrane transport   • chemical homeostasis   • negative regulation of calcium ion transmembrane transport   • cellular localization   • inorganic ion homeostasis   • transport   • homeostatic process   • monoatomic ion transmembrane transport   • negative regulation of monoatomic ion transport   • positive regulation of biological process   • calcium ion homeostasis   • regulation of monoatomic ion transmembrane transport   • negative regulation of sequestering of calcium ion   • metal ion transport   • negative regulation of transmembrane transport   • maintenance of location in cell   • regulation of calcium ion transmembrane transport   • monoatomic cation transmembrane transport   • positive regulation of sequestering of calcium ion   • negative regulation of monoatomic ion transmembrane transport   • negative regulation of release of sequestered calcium ion into cytosol   • intracellular monoatomic cation homeostasis   • monoatomic ion homeostasis   • negative regulation of cellular process   • monoatomic ion transport   • intracellular chemical homeostasis   • regulation of metal ion transport   • regulation of sequestering of calcium ion   • positive regulation of cellular process   • calcium ion transmembrane import into cytosol   • regulation of transport   • sequestering of calcium ion   • negative regulation of calcium ion transport   • cellular homeostasis   • regulation of monoatomic cation transmembrane transport   • calcium ion transmembrane transport   • regulation of postsynaptic membrane potential   • regulation of system process   • regulation of signal transduction   • chemical synaptic transmission, postsynaptic   • synaptic signaling   • positive regulation of inhibitory postsynaptic potential   • positive regulation of nervous system process   • regulation of multicellular organismal process   • regulation of biological quality   • modulation of inhibitory postsynaptic potential   • trans-synaptic signaling   • regulation of signaling   • cell surface receptor signaling pathway   • cell-cell signaling   • regulation of nervous system process   • chemical synaptic transmission   • regulation of response to stimulus   • anterograde trans-synaptic signaling   • inhibitory postsynaptic potential   • positive regulation of multicellular organismal process   • regulation of cell communication   • regulation of membrane potential   • negative regulation of programmed cell death   • regulation of apoptotic process   • regulation of programmed cell death   • cell death   • negative regulation of apoptotic process   • apoptotic process   • programmed cell death   • regulation of biosynthetic process   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • positive regulation of macromolecule biosynthetic process   • regulation of gene expression   • positive regulation of metabolic process   • biosynthetic process   • positive regulation of gene expression   • positive regulation of biosynthetic process   • regulation of macromolecule biosynthetic process   • metabolic process   • positive regulation of macromolecule metabolic process   • macromolecule metabolic process   • regulation of metabolic process   • positive regulation of programmed cell death   • positive regulation of apoptotic process   • import into cell   • nitrogen compound transport   • organic anion transport   • carboxylic acid transport   • carboxylic acid transmembrane transport   • aspartate transmembrane transport   • import across plasma membrane   • amino acid transmembrane transport   • C4-dicarboxylate transport   • D-amino acid transport   • organic acid transport   • amino acid transport   • acidic amino acid transport   • D-aspartate transmembrane transport   • D-aspartate import across plasma membrane   • dicarboxylic acid transport   • amino acid import across plasma membrane   • positive regulation of arachidonate secretion   • regulation of lipid transport   • regulation of arachidonate secretion   • arachidonate secretion   • monocarboxylic acid transport   • positive regulation of secretion   • fatty acid transport   • icosanoid transport   • regulation of icosanoid secretion   • icosanoid secretion   • long-chain fatty acid transport   • positive regulation of icosanoid secretion   • secretion   • arachidonate transport   • lipid localization   • lipid transport   • positive regulation of lipid localization   • regulation of fatty acid transport   • regulation of secretion   • positive regulation of organic acid transport   • positive regulation of lipid transport   • positive regulation of transport   • regulation of lipid localization   • macromolecule localization   • regulation of organic acid transport   • positive regulation of fatty acid transport   • regulation of membrane depolarization   • membrane depolarization   • polyol metabolic process   • alcohol catabolic process   • catabolic process   • polyol catabolic process   • organophosphate catabolic process   • alcohol metabolic process   • inositol phosphate metabolic process   • organophosphate metabolic process   • phosphate-containing compound metabolic process   • inositol phosphate catabolic process   • small molecule metabolic process   • small molecule catabolic process   • phosphorus metabolic process   • detection of external stimulus   • detection of stimulus involved in sensory perception of pain   • response to external stimulus   • sensory perception of temperature stimulus   • sensory perception of pain   • detection of temperature stimulus involved in sensory perception   • response to temperature stimulus   • detection of abiotic stimulus   • detection of stimulus   • sensory perception   • detection of temperature stimulus   • response to abiotic stimulus   • detection of stimulus involved in sensory perception   • detection of temperature stimulus involved in sensory perception of pain   • L-glutamate import across plasma membrane   • L-amino acid transport   • L-glutamate import   • L-alpha-amino acid transmembrane transport   • L-glutamate transmembrane transport   • multicellular organismal-level homeostasis   • temperature homeostasis   • regulation of systemic arterial blood pressure   • circulatory system process   • regulation of blood pressure   • negative regulation of systemic arterial blood pressure   • blood circulation   • negative regulation of blood pressure   • positive regulation of amine transport   • gamma-aminobutyric acid transport   • regulation of amino acid transport   • gamma-aminobutyric acid secretion   • regulation of gamma-aminobutyric acid secretion   • positive regulation of gamma-aminobutyric acid secretion   • acid secretion   • amine transport   • positive regulation of amino acid transport   • regulation of amine transport   • positive regulation of cation transmembrane transport   • positive regulation of calcium ion transport   • positive regulation of monoatomic ion transport   • positive regulation of monoatomic ion transmembrane transport   • positive regulation of calcium ion transmembrane transport   • positive regulation of transmembrane transport   • positive regulation of release of sequestered calcium ion into cytosol   • regulation of respiratory gaseous exchange   • respiratory gaseous exchange by respiratory system   • response to lipid   • response to chemical   • regulation of glutamate secretion   • positive regulation of secretion by cell   • secretion by cell   • regulation of secretion by cell   • glutamate secretion   • positive regulation of glutamate secretion   • export from cell   • regulation of inositol phosphate biosynthetic process   • positive regulation of phosphate metabolic process   • regulation of primary metabolic process   • regulation of small molecule metabolic process   • polyol biosynthetic process   • regulation of carbohydrate metabolic process   • carbohydrate metabolic process   • positive regulation of phosphorus metabolic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • carbohydrate biosynthetic process   • primary metabolic process   • positive regulation of inositol phosphate biosynthetic process   • organophosphate biosynthetic process   • inositol phosphate biosynthetic process   • alcohol biosynthetic process   • regulation of phosphorus metabolic process   • positive regulation of carbohydrate metabolic process   • regulation of carbohydrate biosynthetic process   • positive regulation of small molecule metabolic process   • positive regulation of alcohol biosynthetic process   • symmetric synapse   • cellular anatomical structure   • neuron to neuron synapse   • synapse   • cell junction   • somatodendritic compartment   • cell body   • perikaryon   • neuronal cell body   • axon   • neuron projection   • axon terminus   • plasma membrane bounded cell projection   • presynapse
Gene OntologyCellular Component• symmetric synapse   • cellular anatomical structure   • neuron to neuron synapse   • synapse   • cell junction   • somatodendritic compartment   • cell body   • perikaryon   • neuronal cell body   • axon   • neuron projection   • axon terminus   • plasma membrane bounded cell projection   • presynapse   • cell projection   • distal axon   • terminal bouton   • neuron projection terminus   • cell surface   • cell periphery   • plasma membrane   • membrane   • membrane microdomain   • membrane raft   • membrane-bounded organelle   • intracellular organelle   • intracellular anatomical structure   • Golgi apparatus   • organelle   • cytoplasm   • intracellular membrane-bounded organelle   • endomembrane system   • dendrite   • dendritic tree   • dendritic shaft   • neuron spine   • dendritic spine   • postsynapse   • cytoplasmic side of plasma membrane   • cytoplasmic side of membrane   • side of membrane   • endoplasmic reticulum   • protein binding   • binding   • arrestin family protein binding   • GTPase regulator activity   • enzyme regulator activity   • enzyme activator activity   • GTPase activator activity   • molecular function activator activity   • nucleoside-triphosphatase regulator activity   • molecular function regulator activity   • angiotensin receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • molecular adaptor activity   • ubiquitin protein ligase binding   • ubiquitin-like protein ligase binding   • enzyme binding   • insulin-like growth factor receptor binding   • molecular function inhibitor activity   • enzyme inhibitor activity   • transcription coactivator activity   • transcription regulator activity   • transcription coregulator activity   • protein-macromolecule adaptor activity   • interleukin-6 production   • multicellular organismal process   • regulation of cellular process   • negative regulation of biological process   • regulation of interleukin-6 production   • regulation of cytokine production   • cytokine production   • negative regulation of cellular process   • regulation of multicellular organismal process   • negative regulation of macromolecule metabolic process   • regulation of biosynthetic process   • regulation of biological process   • negative regulation of metabolic process   • biological regulation   • negative regulation of cytokine production   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • regulation of gene expression   • negative regulation of interleukin-6 production   • negative regulation of gene expression   • biosynthetic process   • negative regulation of biosynthetic process   • negative regulation of macromolecule biosynthetic process   • regulation of macromolecule biosynthetic process   • metabolic process   • cellular process   • macromolecule metabolic process   • negative regulation of multicellular organismal process   • regulation of metabolic process   • negative regulation of post-translational protein modification   • regulation of protein modification process   • regulation of protein ubiquitination   • regulation of primary metabolic process   • protein ubiquitination   • negative regulation of protein modification process   • protein metabolic process   • negative regulation of protein ubiquitination   • regulation of protein modification by small protein conjugation or removal   • protein modification process   • negative regulation of protein metabolic process   • negative regulation of protein modification by small protein conjugation or removal   • regulation of post-translational protein modification   • regulation of protein metabolic process   • primary metabolic process   • macromolecule modification   • post-translational protein modification   • protein modification by small protein conjugation   • protein modification by small protein conjugation or removal   • actomyosin structure organization   • actin cytoskeleton organization   • actin filament organization   • cellular component organization   • cellular component biogenesis   • organelle organization   • cellular component assembly   • actin filament bundle organization   • contractile actin filament bundle assembly   • actin filament-based process   • actin filament bundle assembly   • stress fiber assembly   • cellular component organization or biogenesis   • supramolecular fiber organization   • cytoskeleton organization   • catabolic process   • proteolysis involved in protein catabolic process   • protein catabolic process   • macromolecule catabolic process   • modification-dependent macromolecule catabolic process   • modification-dependent protein catabolic process   • proteolysis   • ubiquitin-dependent protein catabolic process   • muscle hypertrophy   • regulation of muscle adaptation   • system process   • positive regulation of cardiac muscle hypertrophy   • response to stimulus   • regulation of system process   • positive regulation of biological process   • striated muscle hypertrophy   • regulation of muscle system process   • muscle system process   • regulation of cardiac muscle hypertrophy   • regulation of muscle hypertrophy   • muscle adaptation   • regulation of response to stimulus   • positive regulation of muscle hypertrophy   • cardiac muscle hypertrophy   • positive regulation of multicellular organismal process   • negative regulation of interleukin-8 production   • interleukin-8 production   • regulation of interleukin-8 production   • positive regulation of DNA-templated transcription   • RNA metabolic process   • positive regulation of macromolecule biosynthetic process   • nucleobase-containing compound metabolic process   • RNA biosynthetic process   • nucleic acid biosynthetic process   • positive regulation of metabolic process   • DNA-templated transcription   • regulation of RNA metabolic process   • transcription by RNA polymerase II   • positive regulation of biosynthetic process   • positive regulation of macromolecule metabolic process   • regulation of nucleobase-containing compound metabolic process   • positive regulation of cellular process   • regulation of RNA biosynthetic process   • regulation of transcription by RNA polymerase II   • positive regulation of transcription by RNA polymerase II   • nucleobase-containing compound biosynthetic process   • nucleic acid metabolic process   • positive regulation of RNA metabolic process   • positive regulation of RNA biosynthetic process   • regulation of DNA-templated transcription   • cellular response to stimulus   • negative adaptation of signaling pathway   • import into cell   • receptor internalization   • negative regulation of signaling   • signaling   • transport   • desensitization of G protein-coupled receptor signaling pathway   • regulation of signal transduction   • negative regulation of G protein-coupled receptor signaling pathway   • negative regulation of cell communication   • vesicle-mediated transport   • cell communication   • localization   • signal transduction   • regulation of G protein-coupled receptor signaling pathway   • G protein-coupled receptor internalization   • regulation of signaling   • negative regulation of response to stimulus   • negative regulation of signal transduction   • establishment of localization   • adaptation of signaling pathway   • regulation of cell communication   • G protein-coupled receptor signaling pathway   • receptor-mediated endocytosis   • endocytosis   • positive regulation of cell communication   • positive regulation of signal transduction   • intracellular signal transduction   • positive regulation of response to stimulus   • positive regulation of ERK1 and ERK2 cascade   • regulation of intracellular signal transduction   • intracellular signaling cassette   • positive regulation of MAPK cascade   • positive regulation of intracellular signal transduction   • regulation of MAPK cascade   • MAPK cascade   • ERK1 and ERK2 cascade   • regulation of ERK1 and ERK2 cascade   • positive regulation of signaling   • establishment of protein localization   • nitrogen compound transport   • protein transport   • macromolecule localization   • intracellular protein localization   • regulation of localization   • regulation of cellular component organization   • positive regulation of cellular component organization   • regulation of receptor internalization   • positive regulation of endocytosis   • positive regulation of receptor-mediated endocytosis   • regulation of endocytosis   • regulation of transport   • regulation of receptor-mediated endocytosis   • regulation of vesicle-mediated transport   • positive regulation of receptor internalization   • positive regulation of transport   • small GTPase-mediated signal transduction   • regulation of small GTPase mediated signal transduction   • Rho protein signal transduction   • regulation of Rho protein signal transduction   • positive regulation of Rho protein signal transduction   • positive regulation of small GTPase mediated signal transduction   • proteasomal protein catabolic process   • proteasome-mediated ubiquitin-dependent protein catabolic process   • negative regulation of DNA-binding transcription factor activity   • negative regulation of NF-kappaB transcription factor activity   • negative regulation of molecular function   • regulation of molecular function   • regulation of DNA-binding transcription factor activity   • cell surface receptor signaling pathway   • Notch signaling pathway   • negative regulation of Notch signaling pathway   • regulation of Notch signaling pathway   • positive regulation of phosphorylation   • regulation of protein phosphorylation   • positive regulation of protein metabolic process   • positive regulation of phosphate metabolic process   • positive regulation of protein modification process   • phosphate-containing compound metabolic process   • positive regulation of protein phosphorylation   • phosphorus metabolic process   • protein phosphorylation   • positive regulation of phosphorus metabolic process   • phosphorylation   • regulation of phosphorus metabolic process   • regulation of phosphorylation   • pseudopodium   • clathrin-coated pit   • cytosol   • membraneless organelle   • intracellular membraneless organelle   • chromatin   • chromosome   • intracellular vesicle   • cytoplasmic vesicle membrane   • bounding membrane of organelle   • cytoplasmic vesicle   • vesicle membrane   • endocytic vesicle membrane   • vesicle   • organelle membrane   • endocytic vesicle   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • lysosomal membrane   • lysosome   • Golgi membrane   • nucleus   • membrane-enclosed lumen   • intracellular organelle lumen   • nucleoplasm   • organelle lumen   • nuclear lumen   • nuclear body
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeTPO
PDB ResiduesR:R:?407
Environment DetailsOpen EMBL-EBI Page
CodeTPO
NamePHOSPHOTHREONINE
SynonymsPHOSPHONOTHREONINE
Identifier
FormulaC4 H10 N O6 P
Molecular Weight199.099
SMILES
PubChem139055008
Formal Charge0
Total Atoms22
Total Chiral Atoms2
Total Bonds21
Total Aromatic Bonds0

CodeSEP
PDB ResiduesR:R:?409 R:R:?410
Environment DetailsOpen EMBL-EBI Page
CodeSEP
NameDexfosfoserine
SynonymsPHOSPHONOSERINE
Identifier
FormulaC3 H8 N O6 P
Molecular Weight185.072
SMILES
PubChem68841
Formal Charge0
Total Atoms19
Total Chiral Atoms1
Total Bonds18
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP30989
Sequence
>9M0D_Chain_R
IYSKVLVTA VYLALFVVG TVGNTVTAF TLARSTVHY HLGSLALSD 
LLTLLLAMP VELYNFIWG CRGYYFLRD ACTYATALN VASLSVERY 
LACSRTKKF ISAIWLASA LLAVPMLFT MGEQNHTAT VKVVIQVNT 
FMSFIFPMV VISVLNTII ANKLTVMVR HGVRVLRAV VIAFVVCWL 
PYHVRRLMF CYISDEQWT PFLYDFYHY FYMVTNALF YVSSTINPI 
LYNLVSANF RHIFLATLA CLNHLNAL? ??


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainV
ProteinArrestin
UniProtP49407
Sequence
>9M0D_Chain_V
TRVFKKASP NGKLTVYLG KRDFVDHID LVDPVDGVV LVDPEYLKE 
RRVYVTLTC AFRYGREDL DVLGLTFRK DLFVANVQS FPPAPEDKK 
PLTRLQERL IKKLGEHAY PFTFEIPPN LPCSVTLQP GPEDTGKAC 
GVDYEVKAF CAENLEEKI HKRNSVRLV IRKVQYAPE RPGPQPTAE 
TTRQFLMSD KPLHLEASL DKEIYYHGE PISVNVHVT NNTNKTVKK 
IKISVRQYA DICLFNTAQ YKCPVAMEE ADDTVAPSS TFCKVYTLT 
PFLANNREK RGLALDGKL KHEDTNLAS STLLREGAN REILGIIVS 
YKVKVKLVV SRGGLLGDL ASSDVAVEL PFTLMHPKP KEEPPHREV 
P


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8JPBAPeptideNeurotensinNTS1Homo sapiensNeurotensin-(8-13)SBI-553; GDP; MgGq; GRK23.072023-08-09doi.org/10.1038/s41586-023-06395-9
8JPB (No Gprot) APeptideNeurotensinNTS1Homo sapiensNeurotensin-(8-13)SBI-553; GDP; Mg3.072023-08-09doi.org/10.1038/s41586-023-06395-9
8JPCAPeptideNeurotensinNTS1Homo sapiensNeurotensin-(8-13)SBI-553; GDP; MgGq; GRK23.072023-08-09doi.org/10.1038/s41586-023-06395-9
8JPC (No Gprot) APeptideNeurotensinNTS1Homo sapiensNeurotensin-(8-13)SBI-553; GDP; Mg3.072023-08-09doi.org/10.1038/s41586-023-06395-9
8FN0APeptideNeurotensinNTS1Rattus norvegicusNeurotensin/Neuromedin-NSBI-553chim(NtGi1-Go)/β1/γ22.892023-03-29doi.org/10.1021/acs.biochem.3c00029
8FN0 (No Gprot) APeptideNeurotensinNTS1Rattus norvegicusNeurotensin/Neuromedin-NSBI-5532.892023-03-29doi.org/10.1021/acs.biochem.3c00029
8JPFAPeptideNeurotensinNTS1Homo sapiensNeurotensinSBI-553-3.022023-08-09doi.org/10.1038/s41586-023-06395-9
8ZYTAPeptideNeurotensinNTS1Homo sapiensNeurotensin peptide 8-13SBI-553Arrestin22.652025-04-09doi.org/10.1038/s41422-025-01095-7
8ZYYAPeptideNeurotensinNTS1Homo sapiensNeurotensin peptide 8-13SBI-553Arrestin22.832025-04-09doi.org/10.1038/s41422-025-01095-7
8ZYUAPeptideNeurotensinNTS1Homo sapiensNeurotensin peptide 8-13SBI-553Arrestin22.652025-04-16doi.org/10.1038/s41422-025-01095-7
7UL2APeptideNeurotensinNTS1Homo sapiensSR48692Na-2.42022-06-29doi.org/10.1038/s41594-022-00859-8
8FMZAPeptideNeurotensinNTS1Rattus norvegicusNeurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ22.592023-03-29doi.org/10.1021/acs.biochem.3c00029
8FMZ (No Gprot) APeptideNeurotensinNTS1Rattus norvegicusNeurotensin/Neuromedin-N-2.592023-03-29doi.org/10.1021/acs.biochem.3c00029
8FN1APeptideNeurotensinNTS1Rattus norvegicusNeurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ22.882023-03-29doi.org/10.1021/acs.biochem.3c00029
8FN1 (No Gprot) APeptideNeurotensinNTS1Rattus norvegicusNeurotensin/Neuromedin-N-2.882023-03-29doi.org/10.1021/acs.biochem.3c00029
4GRVAPeptideNeurotensinNTS1Rattus norvegicusNeurotensin-(8-13)--2.82012-10-17doi.org/10.1038/nature11558
4XEEAPeptideNeurotensinNTS1Rattus norvegicusNeurotensin--2.92015-07-29doi.org/10.1038/ncomms8895
4XESAPeptideNeurotensinNTS1Rattus norvegicusNeurotensin--2.62015-07-29doi.org/10.1038/ncomms8895
6PWCAPeptideNeurotensinNTS1Homo sapiensNeurotensin-Arrestin24.92019-12-04doi.org/10.1038/s41422-019-0256-2
6OS9APeptideNeurotensinNTS1Homo sapiensJMV449-Gi1/β1/γ232019-07-10doi.org/10.1038/s41586-019-1337-6
6OS9 (No Gprot) APeptideNeurotensinNTS1Homo sapiensJMV449-32019-07-10doi.org/10.1038/s41586-019-1337-6
6OSAAPeptideNeurotensinNTS1Homo sapiensJMV449-Gi1/β1/γ232019-07-10doi.org/10.1038/s41586-019-1337-6
6OSA (No Gprot) APeptideNeurotensinNTS1Homo sapiensJMV449-32019-07-10doi.org/10.1038/s41586-019-1337-6
6UP7APeptideNeurotensinNTS1Homo sapiensNeurotensin-Arrestin24.22020-02-26doi.org/10.1038/s41586-020-1953-1
7L0PAPeptideNeurotensinNTS1Rattus norvegicusNeurotensin-Gi1/β1/γ14.12021-01-06doi.org/10.1038/s41594-020-00554-6
7L0P (No Gprot) APeptideNeurotensinNTS1Rattus norvegicusNeurotensin-4.12021-01-06doi.org/10.1038/s41594-020-00554-6
7L0QAPeptideNeurotensinNTS1Rattus norvegicusNeurotensin-Gi1/β1/γ14.32021-01-06doi.org/10.1038/s41594-020-00554-6
7L0Q (No Gprot) APeptideNeurotensinNTS1Rattus norvegicusNeurotensin-4.32021-01-06doi.org/10.1038/s41594-020-00554-6
7L0RAPeptideNeurotensinNTS1Rattus norvegicusNeurotensin-Gi1/β1/γ14.22021-01-06doi.org/10.1038/s41594-020-00554-6
7L0R (No Gprot) APeptideNeurotensinNTS1Rattus norvegicusNeurotensin-4.22021-01-06doi.org/10.1038/s41594-020-00554-6
7L0SAPeptideNeurotensinNTS1Rattus norvegicusNeurotensin-Gi1/β1/γ14.52021-01-06doi.org/10.1038/s41594-020-00554-6
7L0S (No Gprot) APeptideNeurotensinNTS1Rattus norvegicusNeurotensin-4.52021-01-06doi.org/10.1038/s41594-020-00554-6
5T04APeptideNeurotensinNTS1Rattus norvegicusNeurotensin--3.32016-12-21doi.org/10.1038/srep38564
3ZEVAPeptideNeurotensinNTS1Rattus norvegicusNeurotensin--32014-01-29doi.org/10.1073/pnas.1317903111
4BUOAPeptideNeurotensinNTS1Rattus norvegicusNeurotensin--2.752014-01-29doi.org/10.1073/pnas.1317903111
4BV0APeptideNeurotensinNTS1Rattus norvegicusNeurotensin--3.12014-01-29doi.org/10.1073/pnas.1317903111
4BWBAPeptideNeurotensinNTS1Rattus norvegicusNeurotensin--3.572014-01-29doi.org/10.1073/pnas.1317903111
6YVRAPeptideNeurotensinNTS1Rattus norvegicusNTS8-13--2.462021-02-10doi.org/10.1126/sciadv.abe5504
6Z4QAPeptideNeurotensinNTS1Rattus norvegicusSR142948A--2.922021-02-10doi.org/10.1126/sciadv.abe5504
6Z4SAPeptideNeurotensinNTS1Rattus norvegicusSR48692--2.712021-02-10doi.org/10.1126/sciadv.abe5504
6Z4VAPeptideNeurotensinNTS1Rattus norvegicusNTS8-13--2.62021-02-10doi.org/10.1126/sciadv.abe5504
6Z66APeptideNeurotensinNTS1Rattus norvegicus---3.192021-02-10doi.org/10.1126/sciadv.abe5504
6Z8NAPeptideNeurotensinNTS1Rattus norvegicusSRI-9829--2.82021-02-10doi.org/10.1126/sciadv.abe5504
6ZA8APeptideNeurotensinNTS1Rattus norvegicusRTI-3a--2.722021-02-10doi.org/10.1126/sciadv.abe5504
6ZINAPeptideNeurotensinNTS1Rattus norvegicusSR48692--2.642021-02-10doi.org/10.1126/sciadv.abe5504




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