| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 5W0P | A | Sensory | Opsins | Rhodopsin | Homo sapiens | - | - | Arrestin1 | 3.01 | 2017-08-09 | 10.1016/j.cell.2017.07.002 |
|
A 2D representation of the interactions of TPO in 5W0P
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:D330 | V:V:R19 | 4.76 | 18 | No | Yes | 4 | 5 | 2 | 1 | | R:R:D330 | V:V:K167 | 15.21 | 18 | No | No | 4 | 7 | 2 | 2 | | R:R:A333 | V:V:R19 | 4.15 | 0 | No | Yes | 4 | 5 | 2 | 1 | | R:R:?336 | R:R:V337 | 7.33 | 0 | Yes | No | 6 | 5 | 0 | 1 | | R:R:?336 | V:V:K16 | 15.03 | 0 | Yes | No | 6 | 9 | 0 | 1 | | R:R:?336 | V:V:R19 | 2.99 | 0 | Yes | Yes | 6 | 5 | 0 | 1 | | R:R:?336 | V:V:R172 | 4.98 | 0 | Yes | No | 6 | 5 | 0 | 1 | | R:R:?338 | R:R:V337 | 8.85 | 9 | Yes | No | 8 | 5 | 2 | 1 | | R:R:K339 | R:R:V337 | 4.55 | 9 | No | No | 5 | 5 | 2 | 1 | | R:R:?338 | R:R:K339 | 7.18 | 9 | Yes | No | 8 | 5 | 2 | 2 | | R:R:?338 | V:V:K16 | 4.79 | 9 | Yes | No | 8 | 9 | 2 | 1 | | V:V:K16 | V:V:V171 | 6.07 | 0 | No | Yes | 9 | 7 | 1 | 2 | | V:V:K167 | V:V:R19 | 7.43 | 18 | No | Yes | 7 | 5 | 2 | 1 | | V:V:E149 | V:V:K151 | 10.8 | 4 | No | Yes | 7 | 8 | 2 | 2 | | V:V:E149 | V:V:R172 | 13.96 | 4 | No | No | 7 | 5 | 2 | 1 | | V:V:K151 | V:V:R172 | 3.71 | 4 | Yes | No | 8 | 5 | 2 | 1 | | R:R:?336 | R:R:A335 | 1.29 | 0 | Yes | No | 6 | 6 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 5.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 6.32 | | Average Nodes In Shell | 14.00 | | Average Hubs In Shell | 5.00 | | Average Links In Shell | 17.00 | | Average Links Mediated by Hubs In Shell | 14.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 6TKO | A | Amine | Adrenergic | Beta1 | Meleagris gallopavo | Arformoterol | - | Arrestin2 | 3.3 | 2020-06-17 | 10.1038/s41586-020-2419-1 |
|
A 2D representation of the interactions of TPO in 6TKO
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?362 | R:R:?363 | 26.04 | 0 | No | Yes | 5 | 4 | 0 | 1 | | R:R:?362 | V:V:H295 | 7.38 | 0 | No | No | 5 | 7 | 0 | 1 | | R:R:?363 | V:V:K11 | 19.65 | 10 | Yes | Yes | 4 | 9 | 1 | 2 | | R:R:?363 | V:V:R25 | 17.93 | 10 | Yes | Yes | 4 | 9 | 1 | 2 | | R:R:?363 | V:V:L166 | 5.67 | 10 | Yes | Yes | 4 | 8 | 1 | 2 | | R:R:?363 | V:V:K294 | 6.94 | 10 | Yes | No | 4 | 9 | 1 | 2 | | V:V:K11 | V:V:L166 | 9.87 | 10 | Yes | Yes | 9 | 8 | 2 | 2 | | V:V:L166 | V:V:R25 | 7.29 | 10 | Yes | Yes | 8 | 9 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 16.71 | | Average Nodes In Shell | 7.00 | | Average Hubs In Shell | 4.00 | | Average Links In Shell | 8.00 | | Average Links Mediated by Hubs In Shell | 7.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of TPO in 6TKO
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?360 | V:V:K11 | 5.99 | 0 | Yes | Yes | 3 | 9 | 2 | 1 | | R:R:?362 | R:R:?363 | 26.04 | 0 | No | Yes | 5 | 4 | 1 | 0 | | R:R:?362 | V:V:H295 | 7.38 | 0 | No | No | 5 | 7 | 1 | 2 | | R:R:?363 | V:V:K11 | 19.65 | 10 | Yes | Yes | 4 | 9 | 0 | 1 | | R:R:?363 | V:V:R25 | 17.93 | 10 | Yes | Yes | 4 | 9 | 0 | 1 | | R:R:?363 | V:V:L166 | 5.67 | 10 | Yes | Yes | 4 | 8 | 0 | 1 | | R:R:?363 | V:V:K294 | 6.94 | 10 | Yes | No | 4 | 9 | 0 | 1 | | V:V:F9 | V:V:R25 | 10.69 | 0 | No | Yes | 6 | 9 | 2 | 1 | | V:V:K11 | V:V:V164 | 4.55 | 10 | Yes | No | 9 | 8 | 1 | 2 | | V:V:K11 | V:V:L166 | 9.87 | 10 | Yes | Yes | 9 | 8 | 1 | 1 | | V:V:L166 | V:V:L22 | 5.54 | 10 | Yes | No | 8 | 8 | 1 | 2 | | V:V:L166 | V:V:R25 | 7.29 | 10 | Yes | Yes | 8 | 9 | 1 | 1 | | V:V:L293 | V:V:R25 | 13.36 | 0 | No | Yes | 8 | 9 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 5.00 | | Average Number Of Links With An Hub | 3.00 | | Average Interaction Strength | 15.25 | | Average Nodes In Shell | 12.00 | | Average Hubs In Shell | 5.00 | | Average Links In Shell | 13.00 | | Average Links Mediated by Hubs In Shell | 12.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7R0C | A | Peptide | Vasopressin and oxytocin | V2 | Homo sapiens | Acyclovir triphosphate | - | Arrestin2 | 4.73 | 2022-09-14 | 10.1126/sciadv.abo7761 |
|
A 2D representation of the interactions of TPO in 7R0C
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?357 | R:R:C358 | 5.39 | 0 | No | No | 6 | 5 | 2 | 1 | | R:R:?359 | R:R:C358 | 3.9 | 4 | No | No | 4 | 5 | 0 | 1 | | R:R:C358 | V:V:P14 | 5.65 | 0 | No | No | 5 | 6 | 1 | 2 | | R:R:?359 | R:R:?360 | 29.76 | 4 | No | No | 4 | 6 | 0 | 1 | | R:R:?359 | V:V:K11 | 2.31 | 4 | No | No | 4 | 9 | 0 | 1 | | R:R:?360 | R:R:A361 | 2.58 | 4 | No | No | 6 | 7 | 1 | 2 | | R:R:?360 | V:V:K11 | 2.31 | 4 | No | No | 6 | 9 | 1 | 1 | | V:V:K11 | V:V:V164 | 6.07 | 4 | No | No | 9 | 8 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 11.99 | | Average Nodes In Shell | 8.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 8.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of TPO in 7R0C
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?359 | R:R:C358 | 3.9 | 4 | No | No | 4 | 5 | 1 | 2 | | R:R:?359 | R:R:?360 | 29.76 | 4 | No | No | 4 | 6 | 1 | 0 | | R:R:?359 | V:V:K11 | 2.31 | 4 | No | No | 4 | 9 | 1 | 1 | | R:R:?360 | R:R:A361 | 2.58 | 4 | No | No | 6 | 7 | 0 | 1 | | R:R:?360 | V:V:K11 | 2.31 | 4 | No | No | 6 | 9 | 0 | 1 | | R:R:?362 | R:R:A361 | 2.68 | 4 | Yes | No | 4 | 7 | 2 | 1 | | R:R:A361 | V:V:K10 | 4.82 | 4 | No | Yes | 7 | 9 | 1 | 2 | | R:R:?362 | V:V:K10 | 13.17 | 4 | Yes | Yes | 4 | 9 | 2 | 2 | | V:V:K11 | V:V:V164 | 6.07 | 4 | No | No | 9 | 8 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 11.55 | | Average Nodes In Shell | 8.00 | | Average Hubs In Shell | 2.00 | | Average Links In Shell | 9.00 | | Average Links Mediated by Hubs In Shell | 3.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8WRZ | A | Lipid | Cannabinoid | CB1 | Homo sapiens | 8D0 | - | Arrestin1 | 3.6 | 2024-02-28 | 10.1093/procel/pwad055 |
|
A 2D representation of the interactions of TPO in 8WRZ
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | V:V:K11 | V:V:L166 | 12.69 | 6 | No | No | 9 | 8 | 1 | 2 | | R:R:?414 | V:V:K11 | 5.78 | 6 | Yes | No | 4 | 9 | 0 | 1 | | R:R:?415 | V:V:K11 | 13.87 | 6 | Yes | No | 6 | 9 | 1 | 1 | | V:V:L166 | V:V:R25 | 9.72 | 6 | No | Yes | 8 | 9 | 2 | 2 | | R:R:?415 | V:V:R25 | 12.95 | 6 | Yes | Yes | 6 | 9 | 1 | 2 | | R:R:?415 | V:V:L166 | 4.54 | 6 | Yes | No | 6 | 8 | 1 | 2 | | R:R:?414 | V:V:K294 | 5.78 | 6 | Yes | No | 4 | 9 | 0 | 1 | | R:R:?415 | V:V:K294 | 5.78 | 6 | Yes | No | 6 | 9 | 1 | 1 | | R:R:?414 | R:R:C413 | 10.41 | 6 | Yes | No | 4 | 5 | 0 | 1 | | R:R:?414 | R:R:?415 | 28.83 | 6 | Yes | Yes | 4 | 6 | 0 | 1 | | R:R:?415 | R:R:A416 | 2.58 | 6 | Yes | No | 6 | 7 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 4.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 12.70 | | Average Nodes In Shell | 8.00 | | Average Hubs In Shell | 3.00 | | Average Links In Shell | 11.00 | | Average Links Mediated by Hubs In Shell | 10.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of TPO in 8WRZ
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | V:V:F9 | V:V:R25 | 3.21 | 0 | No | Yes | 6 | 9 | 2 | 1 | | V:V:K11 | V:V:L166 | 12.69 | 6 | No | No | 9 | 8 | 1 | 1 | | R:R:?414 | V:V:K11 | 5.78 | 6 | Yes | No | 4 | 9 | 1 | 1 | | R:R:?415 | V:V:K11 | 13.87 | 6 | Yes | No | 6 | 9 | 0 | 1 | | V:V:D26 | V:V:R25 | 2.38 | 0 | No | Yes | 9 | 9 | 2 | 1 | | V:V:L166 | V:V:R25 | 9.72 | 6 | No | Yes | 8 | 9 | 1 | 1 | | V:V:L293 | V:V:R25 | 3.64 | 0 | Yes | Yes | 8 | 9 | 2 | 1 | | R:R:?415 | V:V:R25 | 12.95 | 6 | Yes | Yes | 6 | 9 | 0 | 1 | | R:R:?415 | V:V:L166 | 4.54 | 6 | Yes | No | 6 | 8 | 0 | 1 | | R:R:?414 | V:V:K294 | 5.78 | 6 | Yes | No | 4 | 9 | 1 | 1 | | R:R:?415 | V:V:K294 | 5.78 | 6 | Yes | No | 6 | 9 | 0 | 1 | | R:R:?414 | R:R:C413 | 10.41 | 6 | Yes | No | 4 | 5 | 1 | 2 | | R:R:?414 | R:R:?415 | 28.83 | 6 | Yes | Yes | 4 | 6 | 1 | 0 | | R:R:?415 | R:R:A416 | 2.58 | 6 | Yes | No | 6 | 7 | 0 | 1 | | R:R:?417 | R:R:A416 | 2.68 | 3 | Yes | No | 4 | 7 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 6.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 11.42 | | Average Nodes In Shell | 12.00 | | Average Hubs In Shell | 5.00 | | Average Links In Shell | 15.00 | | Average Links Mediated by Hubs In Shell | 14.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8WU1 | A | Lipid | Cannabinoid | CB1 | Homo sapiens | KCA | - | Arrestin1 | 3.2 | 2024-03-20 | To be published |
|
A 2D representation of the interactions of TPO in 8WU1
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?432 | V:V:K11 | 13.87 | 0 | Yes | No | 6 | 9 | 1 | 2 | | R:R:?432 | V:V:R25 | 12.95 | 0 | Yes | Yes | 6 | 9 | 1 | 2 | | R:R:?432 | V:V:K294 | 9.25 | 0 | Yes | Yes | 6 | 8 | 1 | 2 | | R:R:?431 | R:R:C430 | 7.81 | 0 | No | No | 4 | 5 | 0 | 1 | | R:R:?431 | R:R:?432 | 28.83 | 0 | No | Yes | 4 | 6 | 0 | 1 | | R:R:?429 | R:R:C430 | 2.69 | 0 | No | No | 6 | 5 | 2 | 1 | | R:R:?432 | R:R:A433 | 2.58 | 0 | Yes | No | 6 | 7 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 18.32 | | Average Nodes In Shell | 8.00 | | Average Hubs In Shell | 3.00 | | Average Links In Shell | 7.00 | | Average Links Mediated by Hubs In Shell | 5.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of TPO in 8WU1
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | V:V:F9 | V:V:R25 | 7.48 | 0 | No | Yes | 7 | 9 | 2 | 1 | | V:V:K11 | V:V:V164 | 6.07 | 0 | No | No | 9 | 8 | 1 | 2 | | V:V:K11 | V:V:L166 | 8.46 | 0 | No | Yes | 9 | 8 | 1 | 2 | | R:R:?432 | V:V:K11 | 13.87 | 0 | Yes | No | 6 | 9 | 0 | 1 | | V:V:L166 | V:V:R25 | 4.86 | 0 | Yes | Yes | 8 | 9 | 2 | 1 | | V:V:L293 | V:V:R25 | 9.72 | 4 | Yes | Yes | 6 | 9 | 2 | 1 | | R:R:?432 | V:V:R25 | 12.95 | 0 | Yes | Yes | 6 | 9 | 0 | 1 | | V:V:L293 | V:V:V167 | 2.98 | 4 | Yes | No | 6 | 5 | 2 | 2 | | V:V:K294 | V:V:V167 | 3.04 | 4 | Yes | No | 8 | 5 | 1 | 2 | | V:V:K294 | V:V:L293 | 2.82 | 4 | Yes | Yes | 8 | 6 | 1 | 2 | | V:V:H362 | V:V:L293 | 15.43 | 4 | No | Yes | 1 | 6 | 2 | 2 | | V:V:H362 | V:V:K294 | 3.93 | 4 | No | Yes | 1 | 8 | 2 | 1 | | R:R:?432 | V:V:K294 | 9.25 | 0 | Yes | Yes | 6 | 8 | 0 | 1 | | R:R:?431 | R:R:C430 | 7.81 | 0 | No | No | 4 | 5 | 1 | 2 | | R:R:?431 | R:R:?432 | 28.83 | 0 | No | Yes | 4 | 6 | 1 | 0 | | R:R:?434 | R:R:A433 | 4.01 | 7 | No | No | 4 | 7 | 2 | 1 | | R:R:?432 | R:R:A433 | 2.58 | 0 | Yes | No | 6 | 7 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 5.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 13.50 | | Average Nodes In Shell | 14.00 | | Average Hubs In Shell | 5.00 | | Average Links In Shell | 17.00 | | Average Links Mediated by Hubs In Shell | 14.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
