| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 5W0P | A | Sensory | Opsins | Rhodopsin | Homo Sapiens | - | - | Arrestin1 | 3.01 | 2017-08-09 | doi.org/10.1016/j.cell.2017.07.002 |
|
A 2D representation of the interactions of TPO in 5W0P
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:D330 | V:V:R19 | 4.76 | 18 | No | Yes | 4 | 5 | 2 | 1 | | R:R:D330 | V:V:K167 | 15.21 | 18 | No | No | 4 | 7 | 2 | 2 | | R:R:A333 | V:V:R19 | 4.15 | 0 | No | Yes | 4 | 5 | 2 | 1 | | R:R:?336 | R:R:V337 | 7.33 | 0 | Yes | No | 6 | 5 | 0 | 1 | | R:R:?336 | V:V:K16 | 15.02 | 0 | Yes | No | 6 | 9 | 0 | 1 | | R:R:?336 | V:V:R19 | 2.99 | 0 | Yes | Yes | 6 | 5 | 0 | 1 | | R:R:?336 | V:V:R172 | 4.98 | 0 | Yes | No | 6 | 5 | 0 | 1 | | R:R:?338 | R:R:V337 | 8.84 | 9 | Yes | No | 8 | 5 | 2 | 1 | | R:R:K339 | R:R:V337 | 4.55 | 9 | No | No | 5 | 5 | 2 | 1 | | R:R:?338 | R:R:K339 | 7.18 | 9 | Yes | No | 8 | 5 | 2 | 2 | | R:R:?338 | V:V:K16 | 4.78 | 9 | Yes | No | 8 | 9 | 2 | 1 | | V:V:K16 | V:V:V171 | 6.07 | 0 | No | Yes | 9 | 7 | 1 | 2 | | V:V:K167 | V:V:R19 | 7.43 | 18 | No | Yes | 7 | 5 | 2 | 1 | | V:V:E149 | V:V:K151 | 10.8 | 4 | No | Yes | 7 | 8 | 2 | 2 | | V:V:E149 | V:V:R172 | 13.96 | 4 | No | No | 7 | 5 | 2 | 1 | | V:V:K151 | V:V:R172 | 3.71 | 4 | Yes | No | 8 | 5 | 2 | 1 | | R:R:?336 | R:R:A335 | 1.29 | 0 | Yes | No | 6 | 6 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 5.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 6.32 | | Average Nodes In Shell | 14.00 | | Average Hubs In Shell | 5.00 | | Average Links In Shell | 17.00 | | Average Links Mediated by Hubs In Shell | 14.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 6TKO | A | Amine | Adrenergic | Beta1 | Meleagris Gallopavo | Arformoterol | - | Arrestin2 | 3.3 | 2020-06-17 | doi.org/10.1038/s41586-020-2419-1 |
|
A 2D representation of the interactions of TPO in 6TKO
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?362 | R:R:?363 | 26.13 | 0 | No | Yes | 4 | 6 | 0 | 1 | | R:R:?362 | V:V:H295 | 7.39 | 0 | No | No | 4 | 7 | 0 | 1 | | R:R:?363 | V:V:K11 | 19.68 | 11 | Yes | Yes | 6 | 9 | 1 | 2 | | R:R:?363 | V:V:R25 | 17.96 | 11 | Yes | Yes | 6 | 9 | 1 | 2 | | R:R:?363 | V:V:L166 | 5.68 | 11 | Yes | Yes | 6 | 8 | 1 | 2 | | R:R:?363 | V:V:K294 | 6.95 | 11 | Yes | No | 6 | 9 | 1 | 2 | | V:V:K11 | V:V:L166 | 9.87 | 11 | Yes | Yes | 9 | 8 | 2 | 2 | | V:V:L166 | V:V:R25 | 7.29 | 11 | Yes | Yes | 8 | 9 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 16.76 | | Average Nodes In Shell | 7.00 | | Average Hubs In Shell | 4.00 | | Average Links In Shell | 8.00 | | Average Links Mediated by Hubs In Shell | 7.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of TPO in 6TKO
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?360 | V:V:K11 | 6 | 0 | Yes | Yes | 6 | 9 | 2 | 1 | | R:R:?362 | R:R:?363 | 26.13 | 0 | No | Yes | 4 | 6 | 1 | 0 | | R:R:?362 | V:V:H295 | 7.39 | 0 | No | No | 4 | 7 | 1 | 2 | | R:R:?363 | V:V:K11 | 19.68 | 11 | Yes | Yes | 6 | 9 | 0 | 1 | | R:R:?363 | V:V:R25 | 17.96 | 11 | Yes | Yes | 6 | 9 | 0 | 1 | | R:R:?363 | V:V:L166 | 5.68 | 11 | Yes | Yes | 6 | 8 | 0 | 1 | | R:R:?363 | V:V:K294 | 6.95 | 11 | Yes | No | 6 | 9 | 0 | 1 | | V:V:F9 | V:V:R25 | 10.69 | 0 | No | Yes | 6 | 9 | 2 | 1 | | V:V:K11 | V:V:V164 | 4.55 | 11 | Yes | No | 9 | 8 | 1 | 2 | | V:V:K11 | V:V:L166 | 9.87 | 11 | Yes | Yes | 9 | 8 | 1 | 1 | | V:V:L166 | V:V:L22 | 5.54 | 11 | Yes | No | 8 | 8 | 1 | 2 | | V:V:L166 | V:V:R25 | 7.29 | 11 | Yes | Yes | 8 | 9 | 1 | 1 | | V:V:L293 | V:V:R25 | 13.36 | 0 | No | Yes | 8 | 9 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 5.00 | | Average Number Of Links With An Hub | 3.00 | | Average Interaction Strength | 15.28 | | Average Nodes In Shell | 12.00 | | Average Hubs In Shell | 5.00 | | Average Links In Shell | 13.00 | | Average Links Mediated by Hubs In Shell | 12.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7R0C | A | Peptide | Vasopressin and Oxytocin | V2 | Homo Sapiens | AVP | - | Arrestin2 | 4.73 | 2022-09-14 | doi.org/10.1126/sciadv.abo7761 |
|
A 2D representation of the interactions of TPO in 7R0C
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?357 | R:R:C358 | 5.38 | 0 | No | No | 6 | 5 | 2 | 1 | | R:R:?359 | R:R:C358 | 3.9 | 4 | No | No | 4 | 5 | 0 | 1 | | R:R:C358 | V:V:P14 | 5.65 | 0 | No | No | 5 | 6 | 1 | 2 | | R:R:?359 | R:R:?360 | 29.75 | 4 | No | No | 4 | 6 | 0 | 1 | | R:R:?359 | V:V:K11 | 2.31 | 4 | No | No | 4 | 9 | 0 | 1 | | R:R:?360 | R:R:A361 | 2.58 | 4 | No | No | 6 | 7 | 1 | 2 | | R:R:?360 | V:V:K11 | 2.31 | 4 | No | No | 6 | 9 | 1 | 1 | | V:V:K11 | V:V:V164 | 6.07 | 4 | No | No | 9 | 8 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 11.99 | | Average Nodes In Shell | 8.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 8.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of TPO in 7R0C
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?359 | R:R:C358 | 3.9 | 4 | No | No | 4 | 5 | 1 | 2 | | R:R:?359 | R:R:?360 | 29.75 | 4 | No | No | 4 | 6 | 1 | 0 | | R:R:?359 | V:V:K11 | 2.31 | 4 | No | No | 4 | 9 | 1 | 1 | | R:R:?360 | R:R:A361 | 2.58 | 4 | No | No | 6 | 7 | 0 | 1 | | R:R:?360 | V:V:K11 | 2.31 | 4 | No | No | 6 | 9 | 0 | 1 | | R:R:?362 | R:R:A361 | 2.67 | 4 | Yes | No | 4 | 7 | 2 | 1 | | R:R:A361 | V:V:K10 | 4.82 | 4 | No | Yes | 7 | 9 | 1 | 2 | | R:R:?362 | V:V:K10 | 13.16 | 4 | Yes | Yes | 4 | 9 | 2 | 2 | | V:V:K11 | V:V:V164 | 6.07 | 4 | No | No | 9 | 8 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 11.55 | | Average Nodes In Shell | 8.00 | | Average Hubs In Shell | 2.00 | | Average Links In Shell | 9.00 | | Average Links Mediated by Hubs In Shell | 3.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8WRZ | A | Lipid | Cannabinoid | CB1 | Homo Sapiens | AM841 | - | Arrestin2 | 3.6 | 2024-02-28 | AM841 |
|
A 2D representation of the interactions of TPO in 8WRZ
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | V:V:K11 | V:V:L166 | 12.69 | 6 | No | No | 9 | 8 | 1 | 2 | | R:R:?414 | V:V:K11 | 5.79 | 6 | Yes | No | 4 | 9 | 0 | 1 | | R:R:?415 | V:V:K11 | 13.89 | 6 | Yes | No | 6 | 9 | 1 | 1 | | V:V:L166 | V:V:R25 | 9.72 | 6 | No | Yes | 8 | 9 | 2 | 2 | | R:R:?415 | V:V:R25 | 12.97 | 6 | Yes | Yes | 6 | 9 | 1 | 2 | | R:R:?415 | V:V:L166 | 4.55 | 6 | Yes | No | 6 | 8 | 1 | 2 | | R:R:?414 | V:V:K294 | 5.79 | 6 | Yes | No | 4 | 9 | 0 | 1 | | R:R:?415 | V:V:K294 | 5.79 | 6 | Yes | No | 6 | 9 | 1 | 1 | | R:R:?414 | R:R:C413 | 10.43 | 6 | Yes | No | 4 | 5 | 0 | 1 | | R:R:?414 | R:R:?415 | 28.93 | 6 | Yes | Yes | 4 | 6 | 0 | 1 | | R:R:?415 | R:R:A416 | 2.59 | 6 | Yes | No | 6 | 7 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 4.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 12.73 | | Average Nodes In Shell | 8.00 | | Average Hubs In Shell | 3.00 | | Average Links In Shell | 11.00 | | Average Links Mediated by Hubs In Shell | 10.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of TPO in 8WRZ
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | V:V:F9 | V:V:R25 | 3.21 | 0 | No | Yes | 6 | 9 | 2 | 1 | | V:V:K11 | V:V:L166 | 12.69 | 6 | No | No | 9 | 8 | 1 | 1 | | R:R:?414 | V:V:K11 | 5.79 | 6 | Yes | No | 4 | 9 | 1 | 1 | | R:R:?415 | V:V:K11 | 13.89 | 6 | Yes | No | 6 | 9 | 0 | 1 | | V:V:D26 | V:V:R25 | 2.38 | 0 | No | Yes | 9 | 9 | 2 | 1 | | V:V:L166 | V:V:R25 | 9.72 | 6 | No | Yes | 8 | 9 | 1 | 1 | | V:V:L293 | V:V:R25 | 3.64 | 0 | Yes | Yes | 8 | 9 | 2 | 1 | | R:R:?415 | V:V:R25 | 12.97 | 6 | Yes | Yes | 6 | 9 | 0 | 1 | | R:R:?415 | V:V:L166 | 4.55 | 6 | Yes | No | 6 | 8 | 0 | 1 | | R:R:?414 | V:V:K294 | 5.79 | 6 | Yes | No | 4 | 9 | 1 | 1 | | R:R:?415 | V:V:K294 | 5.79 | 6 | Yes | No | 6 | 9 | 0 | 1 | | R:R:?414 | R:R:C413 | 10.43 | 6 | Yes | No | 4 | 5 | 1 | 2 | | R:R:?414 | R:R:?415 | 28.93 | 6 | Yes | Yes | 4 | 6 | 1 | 0 | | R:R:?415 | R:R:A416 | 2.59 | 6 | Yes | No | 6 | 7 | 0 | 1 | | R:R:?417 | R:R:A416 | 2.68 | 3 | Yes | No | 4 | 7 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 6.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 11.45 | | Average Nodes In Shell | 12.00 | | Average Hubs In Shell | 5.00 | | Average Links In Shell | 15.00 | | Average Links Mediated by Hubs In Shell | 14.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8WU1 | A | Lipid | Cannabinoid | CB1 | Homo Sapiens | MDMB-Fubinaca | - | Arrestin2 | 3.2 | 2024-03-20 | doi.org/10.1016/j.cell.2023.11.017 |
|
A 2D representation of the interactions of TPO in 8WU1
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?431 | R:R:C430 | 7.82 | 0 | No | No | 4 | 5 | 0 | 1 | | R:R:?431 | R:R:?432 | 28.93 | 0 | No | Yes | 4 | 6 | 0 | 1 | | R:R:?432 | V:V:K11 | 13.89 | 0 | Yes | No | 6 | 9 | 1 | 2 | | R:R:?432 | V:V:R25 | 12.97 | 0 | Yes | Yes | 6 | 9 | 1 | 2 | | R:R:?432 | V:V:K294 | 9.26 | 0 | Yes | Yes | 6 | 8 | 1 | 2 | | R:R:?429 | R:R:C430 | 2.7 | 0 | No | No | 6 | 5 | 2 | 1 | | R:R:?432 | R:R:A433 | 2.59 | 0 | Yes | No | 6 | 7 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 18.38 | | Average Nodes In Shell | 8.00 | | Average Hubs In Shell | 3.00 | | Average Links In Shell | 7.00 | | Average Links Mediated by Hubs In Shell | 5.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of TPO in 8WU1
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?431 | R:R:C430 | 7.82 | 0 | No | No | 4 | 5 | 1 | 2 | | R:R:?431 | R:R:?432 | 28.93 | 0 | No | Yes | 4 | 6 | 1 | 0 | | R:R:?432 | V:V:K11 | 13.89 | 0 | Yes | No | 6 | 9 | 0 | 1 | | R:R:?432 | V:V:R25 | 12.97 | 0 | Yes | Yes | 6 | 9 | 0 | 1 | | R:R:?432 | V:V:K294 | 9.26 | 0 | Yes | Yes | 6 | 8 | 0 | 1 | | R:R:?434 | R:R:A433 | 4.02 | 6 | No | No | 4 | 7 | 2 | 1 | | V:V:F9 | V:V:R25 | 7.48 | 0 | No | Yes | 7 | 9 | 2 | 1 | | V:V:K11 | V:V:V164 | 6.07 | 0 | No | Yes | 9 | 8 | 1 | 2 | | V:V:K11 | V:V:L166 | 8.46 | 0 | No | Yes | 9 | 8 | 1 | 2 | | V:V:L166 | V:V:R25 | 4.86 | 0 | Yes | Yes | 8 | 9 | 2 | 1 | | V:V:L293 | V:V:R25 | 9.72 | 4 | Yes | Yes | 6 | 9 | 2 | 1 | | V:V:L293 | V:V:V167 | 2.98 | 4 | Yes | No | 6 | 5 | 2 | 2 | | V:V:K294 | V:V:V167 | 3.04 | 4 | Yes | No | 8 | 5 | 1 | 2 | | V:V:K294 | V:V:L293 | 2.82 | 4 | Yes | Yes | 8 | 6 | 1 | 2 | | V:V:H362 | V:V:L293 | 9 | 4 | No | Yes | 1 | 6 | 2 | 2 | | V:V:H362 | V:V:K294 | 11.79 | 4 | No | Yes | 1 | 8 | 2 | 1 | | R:R:?432 | R:R:A433 | 2.59 | 0 | Yes | No | 6 | 7 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 5.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 13.53 | | Average Nodes In Shell | 14.00 | | Average Hubs In Shell | 6.00 | | Average Links In Shell | 17.00 | | Average Links Mediated by Hubs In Shell | 15.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8ZYT | A | Peptide | Neurotensin | NTS1 | Homo Sapiens | Neurotensin-(8-13) | SBI-553 | Arrestin2 | 2.65 | 2025-04-09 | doi.org/10.1038/s41422-025-01095-7 |
|
A 2D representation of the interactions of TPO in 8ZYT
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?407 | R:R:H406 | 3.17 | 1 | Yes | No | 7 | 8 | 0 | 1 | | R:R:?407 | R:R:L408 | 6.82 | 1 | Yes | No | 7 | 3 | 0 | 1 | | R:R:?407 | V:V:F9 | 2 | 1 | Yes | No | 7 | 6 | 0 | 1 | | R:R:?407 | V:V:K11 | 16.21 | 1 | Yes | No | 7 | 9 | 0 | 1 | | R:R:?407 | V:V:R25 | 7.98 | 1 | Yes | Yes | 7 | 9 | 0 | 1 | | R:R:?407 | V:V:L166 | 7.96 | 1 | Yes | Yes | 7 | 8 | 0 | 1 | | R:R:?409 | R:R:L408 | 4.71 | 1 | No | No | 6 | 3 | 2 | 1 | | R:R:L408 | V:V:K10 | 5.64 | 0 | No | Yes | 3 | 9 | 1 | 2 | | V:V:F9 | V:V:R25 | 9.62 | 1 | No | Yes | 6 | 9 | 1 | 1 | | V:V:E359 | V:V:F9 | 7 | 1 | No | No | 1 | 6 | 2 | 1 | | V:V:K11 | V:V:V164 | 4.55 | 1 | No | No | 9 | 8 | 1 | 2 | | V:V:K11 | V:V:L166 | 7.05 | 1 | No | Yes | 9 | 8 | 1 | 1 | | V:V:L22 | V:V:V20 | 2.98 | 1 | No | Yes | 8 | 6 | 2 | 2 | | V:V:V164 | V:V:V20 | 4.81 | 0 | No | Yes | 8 | 6 | 2 | 2 | | V:V:L166 | V:V:V20 | 2.98 | 1 | Yes | Yes | 8 | 6 | 1 | 2 | | V:V:L166 | V:V:L22 | 4.15 | 1 | Yes | No | 8 | 8 | 1 | 2 | | V:V:L166 | V:V:R25 | 3.64 | 1 | Yes | Yes | 8 | 9 | 1 | 1 | | V:V:L293 | V:V:R25 | 9.72 | 1 | Yes | Yes | 8 | 9 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 6.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 7.36 | | Average Nodes In Shell | 14.00 | | Average Hubs In Shell | 6.00 | | Average Links In Shell | 18.00 | | Average Links Mediated by Hubs In Shell | 15.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8ZYU | A | Peptide | Neurotensin | NTS1 | Homo Sapiens | Neurotensin-(8-13) | SBI-553 | Arrestin2 | 2.65 | 2025-04-16 | doi.org/10.1038/s41422-025-01095-7 |
|
A 2D representation of the interactions of TPO in 8ZYU
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?404 | V:V:K11 | 7.19 | 0 | No | No | 7 | 9 | 2 | 1 | | R:R:?407 | R:R:H406 | 4.22 | 9 | Yes | No | 7 | 8 | 0 | 1 | | R:R:?407 | R:R:L408 | 6.82 | 9 | Yes | No | 7 | 3 | 0 | 1 | | R:R:?407 | V:V:K11 | 19.68 | 9 | Yes | No | 7 | 9 | 0 | 1 | | R:R:?407 | V:V:R25 | 12.97 | 9 | Yes | Yes | 7 | 9 | 0 | 1 | | R:R:?407 | V:V:L166 | 6.82 | 9 | Yes | No | 7 | 8 | 0 | 1 | | R:R:?407 | V:V:K294 | 6.95 | 9 | Yes | No | 7 | 9 | 0 | 1 | | R:R:?409 | R:R:L408 | 3.53 | 19 | No | No | 6 | 3 | 2 | 1 | | R:R:L408 | V:V:K10 | 7.05 | 0 | No | No | 3 | 9 | 1 | 2 | | V:V:F9 | V:V:R25 | 8.55 | 0 | No | Yes | 6 | 9 | 2 | 1 | | V:V:K11 | V:V:V164 | 4.55 | 0 | No | No | 9 | 8 | 1 | 2 | | V:V:L166 | V:V:L22 | 4.15 | 9 | No | No | 8 | 8 | 1 | 2 | | V:V:L166 | V:V:R25 | 7.29 | 9 | No | Yes | 8 | 9 | 1 | 1 | | V:V:L293 | V:V:R25 | 4.86 | 9 | Yes | Yes | 8 | 9 | 2 | 1 | | V:V:H295 | V:V:K294 | 6.55 | 0 | No | No | 7 | 9 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 6.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 9.58 | | Average Nodes In Shell | 15.00 | | Average Hubs In Shell | 3.00 | | Average Links In Shell | 15.00 | | Average Links Mediated by Hubs In Shell | 9.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8ZYY | A | Peptide | Neurotensin | NTS1 | Homo Sapiens | Neurotensin-(8-13) | SBI-553 | Arrestin2 | 2.83 | 2025-04-09 | doi.org/10.1038/s41422-025-01095-7 |
|
A 2D representation of the interactions of TPO in 8ZYY
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?407 | R:R:H406 | 4.22 | 2 | Yes | No | 7 | 8 | 0 | 1 | | R:R:?407 | R:R:L408 | 4.55 | 2 | Yes | No | 7 | 3 | 0 | 1 | | R:R:?407 | V:V:K11 | 17.37 | 2 | Yes | No | 7 | 9 | 0 | 1 | | R:R:?407 | V:V:R25 | 15.96 | 2 | Yes | Yes | 7 | 9 | 0 | 1 | | R:R:?407 | V:V:L166 | 6.82 | 2 | Yes | No | 7 | 8 | 0 | 1 | | R:R:?409 | R:R:L408 | 4.71 | 2 | Yes | No | 6 | 3 | 2 | 1 | | R:R:L408 | V:V:K10 | 4.23 | 2 | No | Yes | 3 | 9 | 1 | 2 | | R:R:?409 | V:V:K10 | 3.6 | 2 | Yes | Yes | 6 | 9 | 2 | 2 | | V:V:F9 | V:V:R25 | 10.69 | 0 | No | Yes | 6 | 9 | 2 | 1 | | V:V:K11 | V:V:V164 | 4.55 | 2 | No | No | 9 | 8 | 1 | 2 | | V:V:K11 | V:V:L166 | 4.23 | 2 | No | No | 9 | 8 | 1 | 1 | | V:V:L166 | V:V:R25 | 7.29 | 2 | No | Yes | 8 | 9 | 1 | 1 | | V:V:L293 | V:V:R25 | 8.5 | 2 | Yes | Yes | 8 | 9 | 2 | 1 | | R:R:?404 | R:R:H406 | 2.19 | 0 | No | No | 7 | 8 | 2 | 1 | | R:R:H406 | V:V:K294 | 1.31 | 0 | No | No | 8 | 9 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 5.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 9.78 | | Average Nodes In Shell | 13.00 | | Average Hubs In Shell | 5.00 | | Average Links In Shell | 15.00 | | Average Links Mediated by Hubs In Shell | 11.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 9E82 | A | Protein | Chemokine | ACKR3 | Homo Sapiens | CXCL12 (fragment) | - | Arrestin2 | 3.4 | 2025-04-02 | doi.org/10.1038/s41586-025-09024-9 |
|
A 2D representation of the interactions of TPO in 9E82
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | V:V:F9 | V:V:R25 | 16.03 | 7 | No | Yes | 7 | 9 | 1 | 1 | | R:R:?338 | V:V:F9 | 3 | 7 | Yes | No | 6 | 7 | 0 | 1 | | R:R:L340 | V:V:F9 | 4.87 | 0 | No | No | 5 | 7 | 2 | 1 | | R:R:G339 | V:V:K10 | 3.49 | 0 | No | No | 5 | 9 | 1 | 2 | | V:V:K11 | V:V:V164 | 6.07 | 0 | No | No | 9 | 8 | 1 | 2 | | R:R:?338 | V:V:K11 | 4.63 | 7 | Yes | No | 6 | 9 | 0 | 1 | | V:V:L166 | V:V:R25 | 8.5 | 0 | No | Yes | 8 | 9 | 2 | 1 | | V:V:L293 | V:V:R25 | 10.93 | 7 | No | Yes | 6 | 9 | 2 | 1 | | R:R:?338 | V:V:R25 | 3.99 | 7 | Yes | Yes | 6 | 9 | 0 | 1 | | R:R:?338 | V:V:K294 | 6.95 | 7 | Yes | No | 6 | 8 | 0 | 1 | | R:R:?338 | R:R:G339 | 4.21 | 7 | Yes | No | 6 | 5 | 0 | 1 | | V:V:R25 | V:V:V167 | 1.31 | 7 | Yes | No | 9 | 5 | 1 | 2 | | R:R:?338 | R:R:K337 | 1.16 | 7 | Yes | No | 6 | 5 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 6.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 3.99 | | Average Nodes In Shell | 13.00 | | Average Hubs In Shell | 2.00 | | Average Links In Shell | 13.00 | | Average Links Mediated by Hubs In Shell | 10.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of TPO in 9E82
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | V:V:L104 | V:V:V8 | 2.98 | 4 | Yes | No | 9 | 7 | 2 | 1 | | R:R:?341 | V:V:V8 | 6.12 | 0 | Yes | No | 4 | 7 | 0 | 1 | | V:V:K10 | V:V:Y21 | 4.78 | 0 | No | Yes | 9 | 8 | 1 | 2 | | R:R:G339 | V:V:K10 | 3.49 | 0 | No | No | 5 | 9 | 2 | 1 | | R:R:?341 | V:V:K10 | 12.74 | 0 | Yes | No | 4 | 9 | 0 | 1 | | V:V:L104 | V:V:Y21 | 8.21 | 4 | Yes | Yes | 9 | 8 | 2 | 2 | | V:V:L108 | V:V:Y21 | 5.86 | 4 | Yes | Yes | 7 | 8 | 2 | 2 | | V:V:L104 | V:V:L108 | 4.15 | 4 | Yes | Yes | 9 | 7 | 2 | 2 | | V:V:K107 | V:V:L108 | 7.05 | 0 | No | Yes | 9 | 7 | 1 | 2 | | R:R:?341 | V:V:K107 | 11.58 | 0 | Yes | No | 4 | 9 | 0 | 1 | | R:R:L343 | V:V:K107 | 11.28 | 0 | No | No | 3 | 9 | 2 | 1 | | R:R:?341 | R:R:K342 | 4.63 | 0 | Yes | No | 4 | 3 | 0 | 1 | | V:V:T6 | V:V:V8 | 1.59 | 0 | No | No | 5 | 7 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 4.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 8.77 | | Average Nodes In Shell | 11.00 | | Average Hubs In Shell | 4.00 | | Average Links In Shell | 13.00 | | Average Links Mediated by Hubs In Shell | 10.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 9II2 | C | Aminoacid | Metabotropic Glutamate | mGlu3; mGlu3 | Homo Sapiens | Glutamate | - | Arrestin2; Arrestin2 | 3.7 | 2025-03-05 | doi.org/10.1038/s41589-025-01858-8 |
|
A 2D representation of the interactions of TPO in 9II2
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?859 | R:R:A858 | 2.68 | 9 | No | No | 4 | 5 | 1 | 2 | | R:R:A858 | V:V:K10 | 6.42 | 0 | No | No | 5 | 9 | 2 | 2 | | R:R:?859 | R:R:?860 | 17.4 | 9 | No | Yes | 4 | 4 | 1 | 0 | | R:R:?859 | V:V:R7 | 13.43 | 9 | No | No | 4 | 4 | 1 | 1 | | R:R:?860 | R:R:Y861 | 1.93 | 9 | Yes | No | 4 | 4 | 0 | 1 | | R:R:?860 | V:V:R7 | 2 | 9 | Yes | No | 4 | 4 | 0 | 1 | | R:R:?860 | V:V:V8 | 2.45 | 9 | Yes | Yes | 4 | 7 | 0 | 1 | | R:R:?860 | V:V:Y21 | 1.93 | 9 | Yes | Yes | 4 | 8 | 0 | 1 | | R:R:?860 | V:V:K107 | 2.32 | 9 | Yes | No | 4 | 9 | 0 | 1 | | R:R:P863 | R:R:Y861 | 5.56 | 0 | No | No | 5 | 4 | 2 | 1 | | R:R:Y861 | V:V:G5 | 4.35 | 0 | No | No | 4 | 4 | 1 | 2 | | R:R:P863 | R:R:V862 | 3.53 | 0 | No | No | 5 | 6 | 2 | 2 | | R:R:V862 | V:V:V8 | 3.21 | 0 | No | Yes | 6 | 7 | 2 | 1 | | R:R:P863 | V:V:K107 | 11.71 | 0 | No | No | 5 | 9 | 2 | 1 | | V:V:F9 | V:V:R7 | 7.48 | 0 | No | No | 6 | 4 | 2 | 1 | | V:V:V8 | V:V:Y21 | 2.52 | 9 | Yes | Yes | 7 | 8 | 1 | 1 | | V:V:G23 | V:V:V8 | 3.68 | 0 | No | Yes | 8 | 7 | 2 | 1 | | V:V:L104 | V:V:V8 | 2.98 | 0 | No | Yes | 9 | 7 | 2 | 1 | | V:V:K10 | V:V:Y21 | 14.33 | 0 | No | Yes | 9 | 8 | 2 | 1 | | V:V:T19 | V:V:Y21 | 11.24 | 9 | No | Yes | 7 | 8 | 2 | 1 | | V:V:L42 | V:V:T19 | 4.42 | 9 | No | No | 5 | 7 | 2 | 2 | | V:V:V40 | V:V:Y21 | 3.79 | 9 | Yes | Yes | 8 | 8 | 2 | 1 | | V:V:L42 | V:V:Y21 | 5.86 | 9 | No | Yes | 5 | 8 | 2 | 1 | | V:V:L108 | V:V:Y21 | 7.03 | 9 | Yes | Yes | 8 | 8 | 2 | 1 | | V:V:L104 | V:V:V40 | 10.43 | 0 | No | Yes | 9 | 8 | 2 | 2 | | V:V:L108 | V:V:V40 | 2.98 | 9 | Yes | Yes | 8 | 8 | 2 | 2 | | V:V:L108 | V:V:L42 | 12.46 | 9 | Yes | No | 8 | 5 | 2 | 2 | | V:V:K107 | V:V:L108 | 2.82 | 0 | No | Yes | 9 | 8 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 6.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 4.67 | | Average Nodes In Shell | 19.00 | | Average Hubs In Shell | 5.00 | | Average Links In Shell | 28.00 | | Average Links Mediated by Hubs In Shell | 19.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of TPO in 9II2
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:?859 | S:S:A858 | 2.68 | 6 | No | No | 4 | 5 | 1 | 2 | | S:S:A858 | v:v:K10 | 6.42 | 0 | No | No | 5 | 9 | 2 | 2 | | S:S:?859 | S:S:?860 | 17.4 | 6 | No | Yes | 4 | 4 | 1 | 0 | | S:S:?859 | v:v:R7 | 13.43 | 6 | No | No | 4 | 4 | 1 | 1 | | S:S:?860 | S:S:Y861 | 1.93 | 6 | Yes | No | 4 | 4 | 0 | 1 | | S:S:?860 | v:v:R7 | 2 | 6 | Yes | No | 4 | 4 | 0 | 1 | | S:S:?860 | v:v:V8 | 2.45 | 6 | Yes | Yes | 4 | 7 | 0 | 1 | | S:S:?860 | v:v:Y21 | 1.93 | 6 | Yes | Yes | 4 | 8 | 0 | 1 | | S:S:?860 | v:v:K107 | 2.32 | 6 | Yes | No | 4 | 9 | 0 | 1 | | S:S:P863 | S:S:Y861 | 5.56 | 0 | No | No | 5 | 4 | 2 | 1 | | S:S:Y861 | v:v:G5 | 4.35 | 0 | No | No | 4 | 4 | 1 | 2 | | S:S:P863 | S:S:V862 | 3.53 | 0 | No | No | 5 | 6 | 2 | 2 | | S:S:V862 | v:v:V8 | 3.21 | 0 | No | Yes | 6 | 7 | 2 | 1 | | S:S:P863 | v:v:K107 | 11.71 | 0 | No | No | 5 | 9 | 2 | 1 | | v:v:F9 | v:v:R7 | 7.48 | 0 | No | No | 6 | 4 | 2 | 1 | | v:v:V8 | v:v:Y21 | 2.52 | 6 | Yes | Yes | 7 | 8 | 1 | 1 | | v:v:G23 | v:v:V8 | 3.68 | 0 | No | Yes | 8 | 7 | 2 | 1 | | v:v:L104 | v:v:V8 | 2.98 | 0 | No | Yes | 9 | 7 | 2 | 1 | | v:v:K10 | v:v:Y21 | 14.33 | 0 | No | Yes | 9 | 8 | 2 | 1 | | v:v:T19 | v:v:Y21 | 11.24 | 6 | Yes | Yes | 7 | 8 | 2 | 1 | | v:v:L42 | v:v:T19 | 4.42 | 6 | Yes | Yes | 5 | 7 | 2 | 2 | | v:v:V40 | v:v:Y21 | 3.79 | 6 | Yes | Yes | 8 | 8 | 2 | 1 | | v:v:L42 | v:v:Y21 | 5.86 | 6 | Yes | Yes | 5 | 8 | 2 | 1 | | v:v:L108 | v:v:Y21 | 7.03 | 6 | Yes | Yes | 8 | 8 | 2 | 1 | | v:v:L104 | v:v:V40 | 10.43 | 0 | No | Yes | 9 | 8 | 2 | 2 | | v:v:L108 | v:v:V40 | 2.98 | 6 | Yes | Yes | 8 | 8 | 2 | 2 | | v:v:L108 | v:v:L42 | 12.46 | 6 | Yes | Yes | 8 | 5 | 2 | 2 | | v:v:K107 | v:v:L108 | 2.82 | 0 | No | Yes | 9 | 8 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 6.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 4.67 | | Average Nodes In Shell | 19.00 | | Average Hubs In Shell | 7.00 | | Average Links In Shell | 28.00 | | Average Links Mediated by Hubs In Shell | 20.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 9II3 | C | Aminoacid | Metabotropic Glutamate | mGlu3; mGlu3 | Homo Sapiens | Glutamate | - | Arrestin2 | 3.9 | 2025-03-05 | doi.org/10.1038/s41589-025-01858-8 |
|
A 2D representation of the interactions of TPO in 9II3
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?859 | R:R:A858 | 4.02 | 0 | No | No | 4 | 5 | 1 | 2 | | R:R:?859 | R:R:?860 | 28.03 | 0 | No | No | 4 | 4 | 1 | 0 | | R:R:?859 | V:V:R7 | 13.43 | 0 | No | No | 4 | 4 | 1 | 2 | | R:R:?860 | V:V:K107 | 13.89 | 0 | No | No | 4 | 9 | 0 | 1 | | R:R:P863 | V:V:K107 | 6.69 | 0 | No | No | 5 | 9 | 2 | 1 | | V:V:K107 | V:V:L108 | 4.23 | 0 | No | Yes | 9 | 8 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 20.96 | | Average Nodes In Shell | 7.00 | | Average Hubs In Shell | 1.00 | | Average Links In Shell | 6.00 | | Average Links Mediated by Hubs In Shell | 1.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 9IJR | A | Orphan | Orphan | GPR52 | Homo Sapiens | - | C17 | Arrestin2 | 3.86 | 2025-09-03 | doi.org/10.1038/s41422-025-01165-w |
|
A 2D representation of the interactions of TPO in 9IJR
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?488 | R:R:A489 | 2.68 | 0 | No | No | 6 | 5 | 2 | 1 | | R:R:?490 | R:R:A489 | 3.88 | 0 | No | No | 4 | 5 | 0 | 1 | | R:R:?490 | R:R:?491 | 14.93 | 0 | No | Yes | 4 | 6 | 0 | 1 | | R:R:?491 | V:V:K11 | 18.53 | 0 | Yes | No | 6 | 9 | 1 | 2 | | R:R:?491 | V:V:R25 | 8.98 | 0 | Yes | No | 6 | 9 | 1 | 2 | | R:R:?491 | R:R:A492 | 2.59 | 0 | Yes | No | 6 | 7 | 1 | 2 | | R:R:?491 | V:V:K294 | 2.32 | 0 | Yes | No | 6 | 9 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 9.40 | | Average Nodes In Shell | 8.00 | | Average Hubs In Shell | 1.00 | | Average Links In Shell | 7.00 | | Average Links Mediated by Hubs In Shell | 5.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of TPO in 9IJR
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?490 | R:R:A489 | 3.88 | 0 | No | No | 4 | 5 | 1 | 2 | | R:R:?490 | R:R:?491 | 14.93 | 0 | No | Yes | 4 | 6 | 1 | 0 | | R:R:?491 | V:V:K11 | 18.53 | 0 | Yes | No | 6 | 9 | 0 | 1 | | R:R:?491 | V:V:R25 | 8.98 | 0 | Yes | No | 6 | 9 | 0 | 1 | | R:R:?493 | R:R:A492 | 4.02 | 0 | No | No | 4 | 7 | 2 | 1 | | V:V:F9 | V:V:R25 | 8.55 | 0 | No | No | 6 | 9 | 2 | 1 | | V:V:K11 | V:V:V164 | 3.04 | 0 | No | Yes | 9 | 8 | 1 | 2 | | V:V:K11 | V:V:L166 | 7.05 | 0 | No | No | 9 | 8 | 1 | 2 | | V:V:L293 | V:V:R25 | 8.5 | 0 | No | No | 8 | 9 | 2 | 1 | | R:R:?491 | R:R:A492 | 2.59 | 0 | Yes | No | 6 | 7 | 0 | 1 | | R:R:?491 | V:V:K294 | 2.32 | 0 | Yes | No | 6 | 9 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 5.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 9.47 | | Average Nodes In Shell | 12.00 | | Average Hubs In Shell | 2.00 | | Average Links In Shell | 11.00 | | Average Links Mediated by Hubs In Shell | 6.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 9IJS | A | Orphan | Orphan | GPR52 | Homo Sapiens | - | - | Arrestin2 | 3.64 | 2025-09-03 | doi.org/10.1038/s41422-025-01165-w |
|
A 2D representation of the interactions of TPO in 9IJS
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?488 | R:R:?490 | 2.9 | 0 | No | No | 6 | 4 | 1 | 0 | | R:R:?488 | V:V:K160 | 4.8 | 0 | No | No | 6 | 8 | 1 | 2 | | R:R:?488 | V:V:R165 | 5.17 | 0 | No | No | 6 | 5 | 1 | 2 | | R:R:?490 | R:R:A489 | 3.88 | 0 | No | No | 4 | 5 | 0 | 1 | | R:R:?490 | R:R:?491 | 18.67 | 0 | No | No | 4 | 6 | 0 | 1 | | R:R:?491 | V:V:K11 | 23.16 | 0 | No | No | 6 | 9 | 1 | 2 | | R:R:?491 | V:V:R25 | 9.98 | 0 | No | Yes | 6 | 9 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 8.48 | | Average Nodes In Shell | 8.00 | | Average Hubs In Shell | 1.00 | | Average Links In Shell | 7.00 | | Average Links Mediated by Hubs In Shell | 1.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of TPO in 9IJS
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?488 | R:R:?490 | 2.9 | 0 | No | No | 6 | 4 | 2 | 1 | | R:R:?490 | R:R:A489 | 3.88 | 0 | No | No | 4 | 5 | 1 | 2 | | R:R:?490 | R:R:?491 | 18.67 | 0 | No | No | 4 | 6 | 1 | 0 | | R:R:?491 | V:V:K11 | 23.16 | 0 | No | No | 6 | 9 | 0 | 1 | | R:R:?491 | V:V:R25 | 9.98 | 0 | No | Yes | 6 | 9 | 0 | 1 | | V:V:F9 | V:V:R25 | 6.41 | 0 | No | Yes | 6 | 9 | 2 | 1 | | V:V:K11 | V:V:V164 | 3.04 | 0 | No | No | 9 | 8 | 1 | 2 | | V:V:L166 | V:V:R25 | 7.29 | 0 | Yes | Yes | 8 | 9 | 2 | 1 | | V:V:L293 | V:V:R25 | 6.07 | 0 | No | Yes | 8 | 9 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 17.27 | | Average Nodes In Shell | 10.00 | | Average Hubs In Shell | 2.00 | | Average Links In Shell | 9.00 | | Average Links Mediated by Hubs In Shell | 4.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 9LXR | B1 | Peptide | Parathyroid Hormone | PTH1 | Homo Sapiens | LA-PTH Analog | - | Arrestin2 | 3.07 | 2025-09-10 | To be published |
|
A 2D representation of the interactions of TPO in 9LXR
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?501 | V:V:K11 | 6 | 0 | No | Yes | 7 | 9 | 2 | 1 | | R:R:?503 | R:R:H502 | 15.84 | 16 | Yes | No | 3 | 5 | 0 | 1 | | R:R:H502 | V:V:K294 | 5.24 | 16 | No | No | 5 | 9 | 1 | 1 | | R:R:?503 | R:R:?504 | 20.3 | 16 | Yes | No | 3 | 7 | 0 | 1 | | R:R:?503 | V:V:K11 | 16.21 | 16 | Yes | Yes | 3 | 9 | 0 | 1 | | R:R:?503 | V:V:R25 | 5.99 | 16 | Yes | No | 3 | 9 | 0 | 1 | | R:R:?503 | V:V:K294 | 9.26 | 16 | Yes | No | 3 | 9 | 0 | 1 | | R:R:?504 | R:R:V505 | 3.8 | 0 | No | No | 7 | 2 | 1 | 2 | | R:R:?504 | V:V:K10 | 6 | 0 | No | No | 7 | 9 | 1 | 2 | | V:V:F9 | V:V:R25 | 10.69 | 0 | No | No | 6 | 9 | 2 | 1 | | V:V:K11 | V:V:V164 | 6.07 | 0 | Yes | No | 9 | 8 | 1 | 2 | | V:V:K11 | V:V:L166 | 7.05 | 0 | Yes | No | 9 | 8 | 1 | 2 | | V:V:L293 | V:V:R25 | 15.79 | 0 | No | No | 8 | 9 | 2 | 1 | | V:V:H295 | V:V:K294 | 10.48 | 0 | No | No | 7 | 9 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 5.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 13.52 | | Average Nodes In Shell | 14.00 | | Average Hubs In Shell | 2.00 | | Average Links In Shell | 14.00 | | Average Links Mediated by Hubs In Shell | 8.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of TPO in 9LXR
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?504 | R:R:V505 | 3.8 | 0 | No | No | 7 | 2 | 2 | 1 | | R:R:?504 | V:V:K10 | 6 | 0 | No | No | 7 | 9 | 2 | 1 | | R:R:?506 | R:R:V505 | 4.89 | 2 | Yes | No | 4 | 2 | 0 | 1 | | R:R:?506 | R:R:N507 | 10.15 | 2 | Yes | No | 4 | 8 | 0 | 1 | | R:R:?506 | V:V:V8 | 4.89 | 2 | Yes | No | 4 | 7 | 0 | 1 | | R:R:?506 | V:V:K10 | 6.95 | 2 | Yes | No | 4 | 9 | 0 | 1 | | R:R:?506 | V:V:K107 | 9.26 | 2 | Yes | No | 4 | 9 | 0 | 1 | | R:R:N507 | V:V:T6 | 4.39 | 2 | No | No | 8 | 4 | 1 | 2 | | R:R:N507 | V:V:K107 | 6.99 | 2 | No | No | 8 | 9 | 1 | 1 | | V:V:G23 | V:V:V8 | 3.68 | 2 | No | No | 8 | 7 | 2 | 1 | | V:V:L100 | V:V:V8 | 4.47 | 2 | Yes | No | 5 | 7 | 2 | 1 | | V:V:K10 | V:V:Y21 | 10.75 | 0 | No | Yes | 9 | 8 | 1 | 2 | | V:V:L108 | V:V:Y21 | 10.55 | 0 | No | Yes | 8 | 8 | 2 | 2 | | V:V:G23 | V:V:L100 | 3.42 | 2 | No | Yes | 8 | 5 | 2 | 2 | | V:V:K107 | V:V:L108 | 4.23 | 2 | No | No | 9 | 8 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 5.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 7.23 | | Average Nodes In Shell | 12.00 | | Average Hubs In Shell | 3.00 | | Average Links In Shell | 15.00 | | Average Links Mediated by Hubs In Shell | 9.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 9M0D | A | Peptide | Neurotensin | NTS1 | Homo Sapiens | - | - | Arrestin2 | 3.41 | 2025-04-09 | doi.org/10.1038/s41422-025-01095-7 |
|
A 2D representation of the interactions of TPO in 9M0D
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:H406 | R:R:N405 | 19.13 | 0 | No | No | 8 | 7 | 1 | 2 | | R:R:?407 | R:R:H406 | 3.17 | 1 | Yes | No | 7 | 8 | 0 | 1 | | R:R:?407 | R:R:L408 | 4.55 | 1 | Yes | No | 7 | 3 | 0 | 1 | | R:R:?407 | V:V:F9 | 3 | 1 | Yes | No | 7 | 6 | 0 | 1 | | R:R:?407 | V:V:K11 | 6.95 | 1 | Yes | No | 7 | 9 | 0 | 1 | | R:R:?407 | V:V:R25 | 19.95 | 1 | Yes | No | 7 | 9 | 0 | 1 | | R:R:?407 | V:V:L166 | 4.55 | 1 | Yes | Yes | 7 | 8 | 0 | 1 | | R:R:?409 | R:R:L408 | 4.71 | 1 | Yes | No | 6 | 3 | 2 | 1 | | R:R:L408 | V:V:K10 | 5.64 | 1 | No | Yes | 3 | 9 | 1 | 2 | | R:R:?409 | V:V:K10 | 6 | 1 | Yes | Yes | 6 | 9 | 2 | 2 | | V:V:E359 | V:V:F9 | 3.5 | 6 | No | No | 1 | 6 | 2 | 1 | | V:V:K11 | V:V:V164 | 6.07 | 1 | No | No | 9 | 8 | 1 | 2 | | V:V:K11 | V:V:L166 | 8.46 | 1 | No | Yes | 9 | 8 | 1 | 1 | | V:V:V164 | V:V:V20 | 6.41 | 0 | No | Yes | 8 | 6 | 2 | 2 | | V:V:L166 | V:V:V20 | 2.98 | 1 | Yes | Yes | 8 | 6 | 1 | 2 | | V:V:L166 | V:V:L22 | 6.92 | 1 | Yes | No | 8 | 8 | 1 | 2 | | V:V:L293 | V:V:R25 | 10.93 | 0 | No | No | 8 | 9 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 6.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 7.03 | | Average Nodes In Shell | 15.00 | | Average Hubs In Shell | 5.00 | | Average Links In Shell | 17.00 | | Average Links Mediated by Hubs In Shell | 13.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 9MBA | C | Aminoacid | Metabotropic glutamate | mGlu8; mGlu8 | Homo Sapiens | Glutamate | - | Arrestin2 ; Arrestin2 | 3.14 | 2025-10-01 | doi.org/10.1016/j.molcel.2025.08.019 |
|
A 2D representation of the interactions of TPO in 9MBA
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?893 | R:R:S894 | 4.93 | 7 | Yes | No | 4 | 4 | 0 | 1 | | R:R:?893 | V:V:K11 | 8.11 | 7 | Yes | No | 4 | 9 | 0 | 1 | | R:R:?893 | V:V:R25 | 7.98 | 7 | Yes | Yes | 4 | 9 | 0 | 1 | | R:R:?893 | V:V:L166 | 4.55 | 7 | Yes | Yes | 4 | 8 | 0 | 1 | | R:R:?895 | R:R:S894 | 5.11 | 0 | No | No | 5 | 4 | 2 | 1 | | R:R:S894 | V:V:K10 | 9.18 | 0 | No | Yes | 4 | 9 | 1 | 2 | | V:V:F9 | V:V:R25 | 6.41 | 0 | No | Yes | 6 | 9 | 2 | 1 | | V:V:K11 | V:V:L166 | 8.46 | 7 | No | Yes | 9 | 8 | 1 | 1 | | V:V:L166 | V:V:L22 | 4.15 | 7 | Yes | No | 8 | 8 | 1 | 2 | | V:V:L166 | V:V:R25 | 3.64 | 7 | Yes | Yes | 8 | 9 | 1 | 1 | | V:V:L293 | V:V:R25 | 6.07 | 7 | Yes | Yes | 8 | 9 | 2 | 1 | | R:R:?893 | R:R:N892 | 2.26 | 7 | Yes | No | 4 | 7 | 0 | 1 | | R:R:T891 | V:V:K11 | 1.5 | 0 | No | No | 5 | 9 | 2 | 1 | | V:V:H295 | V:V:K294 | 1.31 | 0 | No | No | 7 | 9 | 2 | 1 | | R:R:?893 | V:V:K294 | 1.16 | 7 | Yes | No | 4 | 9 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 6.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 4.83 | | Average Nodes In Shell | 14.00 | | Average Hubs In Shell | 5.00 | | Average Links In Shell | 15.00 | | Average Links Mediated by Hubs In Shell | 12.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of TPO in 9MBA
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?895 | R:R:S894 | 5.11 | 0 | No | No | 5 | 4 | 1 | 2 | | R:R:S894 | V:V:K10 | 9.18 | 0 | No | Yes | 4 | 9 | 2 | 1 | | R:R:?895 | R:R:?896 | 19.33 | 0 | No | Yes | 5 | 5 | 1 | 0 | | R:R:?895 | V:V:R7 | 19.63 | 0 | No | No | 5 | 4 | 1 | 2 | | R:R:?896 | V:V:V8 | 6.12 | 0 | Yes | No | 5 | 7 | 0 | 1 | | R:R:?896 | V:V:K10 | 5.79 | 0 | Yes | Yes | 5 | 9 | 0 | 1 | | R:R:?896 | V:V:K107 | 10.42 | 0 | Yes | No | 5 | 9 | 0 | 1 | | R:R:K897 | R:R:T899 | 6.01 | 0 | No | No | 7 | 5 | 1 | 2 | | R:R:T898 | V:V:V8 | 4.76 | 0 | No | No | 5 | 7 | 2 | 1 | | V:V:G23 | V:V:V8 | 3.68 | 0 | No | No | 8 | 7 | 2 | 1 | | V:V:K10 | V:V:T19 | 3 | 44 | Yes | Yes | 9 | 7 | 1 | 2 | | V:V:K10 | V:V:Y21 | 15.53 | 44 | Yes | Yes | 9 | 8 | 1 | 2 | | V:V:T19 | V:V:Y21 | 6.24 | 44 | Yes | Yes | 7 | 8 | 2 | 2 | | V:V:L108 | V:V:Y21 | 11.72 | 0 | Yes | Yes | 8 | 8 | 2 | 2 | | V:V:K107 | V:V:L108 | 4.23 | 0 | No | Yes | 9 | 8 | 1 | 2 | | R:R:?896 | R:R:K897 | 2.32 | 0 | Yes | No | 5 | 7 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 5.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 8.80 | | Average Nodes In Shell | 14.00 | | Average Hubs In Shell | 5.00 | | Average Links In Shell | 16.00 | | Average Links Mediated by Hubs In Shell | 11.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of TPO in 9MBA
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:N892 | S:S:T891 | 5.85 | 0 | No | No | 7 | 5 | 1 | 2 | | S:S:?893 | S:S:N892 | 3.38 | 0 | Yes | No | 4 | 7 | 0 | 1 | | S:S:N892 | V:V:R161 | 3.62 | 0 | No | No | 7 | 7 | 1 | 2 | | S:S:?893 | S:S:S894 | 7.4 | 0 | Yes | No | 4 | 4 | 0 | 1 | | S:S:?893 | v:v:K11 | 8.11 | 0 | Yes | No | 4 | 9 | 0 | 1 | | S:S:?893 | v:v:R25 | 6.98 | 0 | Yes | Yes | 4 | 9 | 0 | 1 | | S:S:?895 | S:S:S894 | 5.11 | 0 | No | No | 5 | 4 | 2 | 1 | | S:S:S894 | v:v:K10 | 9.18 | 0 | No | No | 4 | 9 | 1 | 2 | | v:v:F9 | v:v:R25 | 4.28 | 0 | No | Yes | 6 | 9 | 2 | 1 | | v:v:K11 | v:v:V164 | 6.07 | 0 | No | No | 9 | 8 | 1 | 2 | | v:v:K11 | v:v:L166 | 11.28 | 0 | No | No | 9 | 8 | 1 | 2 | | v:v:L166 | v:v:R25 | 3.64 | 0 | No | Yes | 8 | 9 | 2 | 1 | | v:v:L293 | v:v:R25 | 7.29 | 26 | Yes | Yes | 8 | 9 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 4.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 6.47 | | Average Nodes In Shell | 13.00 | | Average Hubs In Shell | 3.00 | | Average Links In Shell | 13.00 | | Average Links Mediated by Hubs In Shell | 7.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of TPO in 9MBA
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:?895 | S:S:S894 | 5.11 | 0 | No | No | 5 | 4 | 1 | 2 | | S:S:S894 | v:v:K10 | 9.18 | 0 | No | No | 4 | 9 | 2 | 1 | | S:S:?895 | S:S:?896 | 18.36 | 0 | No | Yes | 5 | 5 | 1 | 0 | | S:S:?895 | v:v:R7 | 14.46 | 0 | No | No | 5 | 4 | 1 | 2 | | S:S:?896 | v:v:K10 | 6.95 | 0 | Yes | No | 5 | 9 | 0 | 1 | | S:S:?896 | v:v:K107 | 10.42 | 0 | Yes | No | 5 | 9 | 0 | 1 | | S:S:K897 | S:S:T899 | 3 | 0 | No | No | 7 | 5 | 1 | 2 | | S:S:K897 | v:v:T6 | 4.5 | 0 | No | No | 7 | 4 | 1 | 2 | | v:v:K10 | v:v:Y21 | 9.55 | 0 | No | Yes | 9 | 8 | 1 | 2 | | S:S:?896 | S:S:K897 | 2.32 | 0 | Yes | No | 5 | 7 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 4.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 9.51 | | Average Nodes In Shell | 10.00 | | Average Hubs In Shell | 2.00 | | Average Links In Shell | 10.00 | | Average Links Mediated by Hubs In Shell | 5.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 9UYH | A | Protein | Chemerin | CML2 | Homo Sapiens | Chemerin-9 | - | Arrestin2 | 3.3 | 2025-11-19 | 10.1126/science.adt8794 |
|
A 2D representation of the interactions of TPO in 9UYH
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?1359 | R:R:C1358 | 3.91 | 0 | No | No | 4 | 5 | 0 | 1 | | R:R:?1359 | R:R:?1360 | 21.46 | 0 | No | Yes | 4 | 6 | 0 | 1 | | R:R:?1360 | V:V:K11 | 12.74 | 0 | Yes | Yes | 6 | 9 | 1 | 2 | | R:R:?1360 | V:V:R25 | 13.97 | 0 | Yes | No | 6 | 9 | 1 | 2 | | R:R:?1360 | V:V:K294 | 3.47 | 0 | Yes | No | 6 | 9 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 12.69 | | Average Nodes In Shell | 6.00 | | Average Hubs In Shell | 2.00 | | Average Links In Shell | 5.00 | | Average Links Mediated by Hubs In Shell | 4.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of TPO in 9UYH
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?1359 | R:R:C1358 | 3.91 | 0 | No | No | 4 | 5 | 1 | 2 | | R:R:?1359 | R:R:?1360 | 21.46 | 0 | No | Yes | 4 | 6 | 1 | 0 | | R:R:?1360 | V:V:K11 | 12.74 | 0 | Yes | Yes | 6 | 9 | 0 | 1 | | R:R:?1360 | V:V:R25 | 13.97 | 0 | Yes | No | 6 | 9 | 0 | 1 | | R:R:?1360 | V:V:K294 | 3.47 | 0 | Yes | No | 6 | 9 | 0 | 1 | | V:V:K11 | V:V:V164 | 4.55 | 0 | Yes | No | 9 | 8 | 1 | 2 | | V:V:K11 | V:V:R165 | 3.71 | 0 | Yes | No | 9 | 5 | 1 | 2 | | V:V:K11 | V:V:L166 | 11.28 | 0 | Yes | No | 9 | 8 | 1 | 2 | | V:V:L166 | V:V:R25 | 3.64 | 0 | No | No | 8 | 9 | 2 | 1 | | V:V:L293 | V:V:R25 | 8.5 | 2 | Yes | No | 8 | 9 | 2 | 1 | | V:V:E296 | V:V:K294 | 5.4 | 0 | No | No | 7 | 9 | 2 | 1 | | V:V:K294 | V:V:R363 | 2.48 | 0 | No | No | 9 | 1 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 4.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 12.91 | | Average Nodes In Shell | 12.00 | | Average Hubs In Shell | 3.00 | | Average Links In Shell | 12.00 | | Average Links Mediated by Hubs In Shell | 8.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 9UYI | A | Protein | Chemerin | CML2 | Homo Sapiens | Chemerin-9 | - | Arrestin2 | 3.2 | 2025-11-19 | 10.1126/science.adt8794 |
|
A 2D representation of the interactions of TPO in 9UYI
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?1357 | R:R:C1358 | 5.4 | 0 | No | No | 6 | 5 | 2 | 1 | | R:R:?1357 | V:V:K11 | 3.6 | 0 | No | Yes | 6 | 9 | 2 | 2 | | R:R:?1357 | V:V:K294 | 3.6 | 0 | No | No | 6 | 9 | 2 | 2 | | R:R:?1359 | R:R:C1358 | 3.91 | 0 | No | No | 4 | 5 | 0 | 1 | | R:R:C1358 | V:V:P14 | 3.77 | 0 | No | No | 5 | 6 | 1 | 2 | | R:R:?1359 | R:R:?1360 | 22.4 | 0 | No | Yes | 4 | 6 | 0 | 1 | | R:R:?1360 | R:R:A1361 | 2.59 | 0 | Yes | No | 6 | 7 | 1 | 2 | | R:R:?1360 | V:V:K11 | 16.21 | 0 | Yes | Yes | 6 | 9 | 1 | 2 | | R:R:?1360 | V:V:R25 | 13.97 | 0 | Yes | Yes | 6 | 9 | 1 | 2 | | R:R:?1360 | V:V:K294 | 4.63 | 0 | Yes | No | 6 | 9 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 13.15 | | Average Nodes In Shell | 9.00 | | Average Hubs In Shell | 3.00 | | Average Links In Shell | 10.00 | | Average Links Mediated by Hubs In Shell | 6.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of TPO in 9UYI
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?1357 | R:R:C1358 | 5.4 | 0 | No | No | 6 | 5 | 2 | 2 | | R:R:?1357 | V:V:K11 | 3.6 | 0 | No | Yes | 6 | 9 | 2 | 1 | | R:R:?1357 | V:V:K294 | 3.6 | 0 | No | No | 6 | 9 | 2 | 1 | | R:R:?1359 | R:R:C1358 | 3.91 | 0 | No | No | 4 | 5 | 1 | 2 | | R:R:?1359 | R:R:?1360 | 22.4 | 0 | No | Yes | 4 | 6 | 1 | 0 | | R:R:?1360 | R:R:A1361 | 2.59 | 0 | Yes | No | 6 | 7 | 0 | 1 | | R:R:?1360 | V:V:K11 | 16.21 | 0 | Yes | Yes | 6 | 9 | 0 | 1 | | R:R:?1360 | V:V:R25 | 13.97 | 0 | Yes | Yes | 6 | 9 | 0 | 1 | | R:R:?1360 | V:V:K294 | 4.63 | 0 | Yes | No | 6 | 9 | 0 | 1 | | R:R:?1362 | R:R:A1361 | 2.68 | 4 | No | No | 4 | 7 | 2 | 1 | | V:V:K11 | V:V:V164 | 4.55 | 0 | Yes | No | 9 | 8 | 1 | 2 | | V:V:K11 | V:V:L166 | 5.64 | 0 | Yes | Yes | 9 | 8 | 1 | 2 | | V:V:L166 | V:V:R25 | 3.64 | 0 | Yes | Yes | 8 | 9 | 2 | 1 | | V:V:I168 | V:V:R25 | 2.51 | 0 | No | Yes | 8 | 9 | 2 | 1 | | V:V:L293 | V:V:R25 | 7.29 | 3 | Yes | Yes | 8 | 9 | 2 | 1 | | V:V:K294 | V:V:R363 | 2.48 | 0 | No | No | 9 | 1 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 5.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 11.96 | | Average Nodes In Shell | 14.00 | | Average Hubs In Shell | 5.00 | | Average Links In Shell | 16.00 | | Average Links Mediated by Hubs In Shell | 11.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 9UYJ | A | Protein | Chemerin | CML2 | Homo Sapiens | Chemerin-9 | - | Arrestin2 | 3.3 | 2025-11-19 | 10.1126/science.adt8794 |
|
A 2D representation of the interactions of TPO in 9UYJ
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?1359 | R:R:C1358 | 3.91 | 0 | No | No | 4 | 5 | 0 | 1 | | R:R:?1359 | R:R:?1360 | 21.46 | 0 | No | Yes | 4 | 6 | 0 | 1 | | R:R:?1360 | R:R:A1361 | 2.59 | 1 | Yes | No | 6 | 7 | 1 | 2 | | R:R:?1360 | V:V:K11 | 11.58 | 1 | Yes | No | 6 | 9 | 1 | 2 | | R:R:?1360 | V:V:R25 | 12.97 | 1 | Yes | Yes | 6 | 9 | 1 | 2 | | R:R:?1360 | V:V:L166 | 6.82 | 1 | Yes | Yes | 6 | 8 | 1 | 2 | | V:V:K11 | V:V:L166 | 7.05 | 1 | No | Yes | 9 | 8 | 2 | 2 | | V:V:L166 | V:V:R25 | 14.58 | 1 | Yes | Yes | 8 | 9 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 12.69 | | Average Nodes In Shell | 7.00 | | Average Hubs In Shell | 3.00 | | Average Links In Shell | 8.00 | | Average Links Mediated by Hubs In Shell | 7.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of TPO in 9UYJ
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?1359 | R:R:C1358 | 3.91 | 0 | No | No | 4 | 5 | 1 | 2 | | R:R:?1359 | R:R:?1360 | 21.46 | 0 | No | Yes | 4 | 6 | 1 | 0 | | R:R:?1360 | R:R:A1361 | 2.59 | 1 | Yes | No | 6 | 7 | 0 | 1 | | R:R:?1360 | V:V:K11 | 11.58 | 1 | Yes | No | 6 | 9 | 0 | 1 | | R:R:?1360 | V:V:R25 | 12.97 | 1 | Yes | Yes | 6 | 9 | 0 | 1 | | R:R:?1360 | V:V:L166 | 6.82 | 1 | Yes | Yes | 6 | 8 | 0 | 1 | | R:R:?1362 | R:R:A1361 | 4.02 | 1 | Yes | No | 4 | 7 | 2 | 1 | | R:R:?1362 | V:V:F9 | 3.11 | 1 | Yes | No | 4 | 6 | 2 | 2 | | V:V:F9 | V:V:R25 | 2.14 | 0 | No | Yes | 6 | 9 | 2 | 1 | | V:V:K11 | V:V:L166 | 7.05 | 1 | No | Yes | 9 | 8 | 1 | 1 | | V:V:L166 | V:V:L22 | 2.77 | 1 | Yes | No | 8 | 8 | 1 | 2 | | V:V:L166 | V:V:R25 | 14.58 | 1 | Yes | Yes | 8 | 9 | 1 | 1 | | V:V:L293 | V:V:R25 | 7.29 | 1 | Yes | Yes | 8 | 9 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 5.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 11.08 | | Average Nodes In Shell | 11.00 | | Average Hubs In Shell | 5.00 | | Average Links In Shell | 13.00 | | Average Links Mediated by Hubs In Shell | 12.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 9UYL | A | Protein | Chemerin | CML2 | Homo Sapiens | Chemerin-9 | - | Arrestin2 | 3.3 | 2025-11-19 | 10.1126/science.adt8794 |
|
A 2D representation of the interactions of TPO in 9UYL
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?1357 | R:R:C1358 | 4.05 | 0 | No | No | 6 | 5 | 2 | 1 | | R:R:?1357 | V:V:K11 | 2.4 | 0 | No | Yes | 6 | 9 | 2 | 1 | | R:R:?1359 | R:R:C1358 | 5.21 | 1 | No | No | 4 | 5 | 0 | 1 | | R:R:C1358 | V:V:P14 | 3.77 | 0 | No | No | 5 | 6 | 1 | 2 | | R:R:?1359 | R:R:?1360 | 23.33 | 1 | No | Yes | 4 | 6 | 0 | 1 | | R:R:?1359 | V:V:K11 | 3.47 | 1 | No | Yes | 4 | 9 | 0 | 1 | | R:R:?1360 | R:R:A1361 | 2.59 | 1 | Yes | No | 6 | 7 | 1 | 2 | | R:R:?1360 | V:V:F9 | 2 | 1 | Yes | No | 6 | 6 | 1 | 2 | | R:R:?1360 | V:V:K11 | 17.37 | 1 | Yes | Yes | 6 | 9 | 1 | 1 | | R:R:?1360 | V:V:R25 | 12.97 | 1 | Yes | Yes | 6 | 9 | 1 | 2 | | R:R:?1360 | V:V:K294 | 2.32 | 1 | Yes | No | 6 | 9 | 1 | 2 | | V:V:F9 | V:V:R25 | 4.28 | 1 | No | Yes | 6 | 9 | 2 | 2 | | V:V:K11 | V:V:L166 | 7.05 | 1 | Yes | No | 9 | 8 | 1 | 2 | | V:V:L166 | V:V:R25 | 9.72 | 0 | No | Yes | 8 | 9 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 10.67 | | Average Nodes In Shell | 11.00 | | Average Hubs In Shell | 3.00 | | Average Links In Shell | 14.00 | | Average Links Mediated by Hubs In Shell | 11.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of TPO in 9UYL
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?1357 | R:R:C1358 | 4.05 | 0 | No | No | 6 | 5 | 2 | 2 | | R:R:?1357 | V:V:K11 | 2.4 | 0 | No | Yes | 6 | 9 | 2 | 1 | | R:R:?1359 | R:R:C1358 | 5.21 | 1 | No | No | 4 | 5 | 1 | 2 | | R:R:?1359 | R:R:?1360 | 23.33 | 1 | No | Yes | 4 | 6 | 1 | 0 | | R:R:?1359 | V:V:K11 | 3.47 | 1 | No | Yes | 4 | 9 | 1 | 1 | | R:R:?1360 | R:R:A1361 | 2.59 | 1 | Yes | No | 6 | 7 | 0 | 1 | | R:R:?1360 | V:V:F9 | 2 | 1 | Yes | No | 6 | 6 | 0 | 1 | | R:R:?1360 | V:V:K11 | 17.37 | 1 | Yes | Yes | 6 | 9 | 0 | 1 | | R:R:?1360 | V:V:R25 | 12.97 | 1 | Yes | Yes | 6 | 9 | 0 | 1 | | R:R:?1360 | V:V:K294 | 2.32 | 1 | Yes | No | 6 | 9 | 0 | 1 | | R:R:?1362 | R:R:A1361 | 4.02 | 6 | Yes | No | 4 | 7 | 2 | 1 | | V:V:F9 | V:V:R25 | 4.28 | 1 | No | Yes | 6 | 9 | 1 | 1 | | V:V:K11 | V:V:L166 | 7.05 | 1 | Yes | No | 9 | 8 | 1 | 2 | | V:V:L166 | V:V:R25 | 9.72 | 0 | No | Yes | 8 | 9 | 2 | 1 | | V:V:L293 | V:V:R25 | 6.07 | 1 | No | Yes | 8 | 9 | 2 | 1 | | V:V:H295 | V:V:K294 | 1.31 | 0 | No | No | 7 | 9 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 6.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 10.10 | | Average Nodes In Shell | 13.00 | | Average Hubs In Shell | 4.00 | | Average Links In Shell | 16.00 | | Average Links Mediated by Hubs In Shell | 13.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 9UYM | A | Protein | Chemerin | CML2 | Homo Sapiens | Chemerin-9 | - | chim(Arrestin3-CtArrestin2) | 3.5 | 2025-11-19 | 10.1126/science.adt8794 |
|
A 2D representation of the interactions of TPO in 9UYM
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?1357 | R:R:C1358 | 4.05 | 0 | Yes | No | 6 | 5 | 2 | 1 | | R:R:?1357 | V:V:K12 | 8.39 | 0 | Yes | No | 6 | 9 | 2 | 2 | | R:R:?1359 | R:R:C1358 | 3.91 | 0 | No | No | 4 | 5 | 0 | 1 | | R:R:C1358 | V:V:P15 | 3.77 | 0 | No | No | 5 | 6 | 1 | 2 | | R:R:?1359 | R:R:?1360 | 19.6 | 0 | No | No | 4 | 6 | 0 | 1 | | R:R:?1360 | V:V:K12 | 17.37 | 0 | No | No | 6 | 9 | 1 | 2 | | R:R:?1360 | V:V:R26 | 13.97 | 0 | No | Yes | 6 | 9 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 11.76 | | Average Nodes In Shell | 7.00 | | Average Hubs In Shell | 2.00 | | Average Links In Shell | 7.00 | | Average Links Mediated by Hubs In Shell | 3.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of TPO in 9UYM
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?1357 | R:R:C1358 | 4.05 | 0 | Yes | No | 6 | 5 | 2 | 2 | | R:R:?1357 | V:V:K12 | 8.39 | 0 | Yes | No | 6 | 9 | 2 | 1 | | R:R:?1359 | R:R:C1358 | 3.91 | 0 | No | No | 4 | 5 | 1 | 2 | | R:R:?1359 | R:R:?1360 | 19.6 | 0 | No | No | 4 | 6 | 1 | 0 | | R:R:?1360 | V:V:K12 | 17.37 | 0 | No | No | 6 | 9 | 0 | 1 | | R:R:?1360 | V:V:R26 | 13.97 | 0 | No | Yes | 6 | 9 | 0 | 1 | | V:V:K12 | V:V:L167 | 8.46 | 0 | No | No | 9 | 8 | 1 | 2 | | V:V:L167 | V:V:R26 | 3.64 | 0 | No | Yes | 8 | 9 | 2 | 1 | | V:V:R26 | V:V:V168 | 3.92 | 0 | Yes | No | 9 | 5 | 1 | 2 | | V:V:H355 | V:V:R26 | 10.16 | 1 | Yes | Yes | 1 | 9 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 16.98 | | Average Nodes In Shell | 9.00 | | Average Hubs In Shell | 3.00 | | Average Links In Shell | 10.00 | | Average Links Mediated by Hubs In Shell | 6.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 9UYN | A | Protein | Chemerin | CML2 | Homo Sapiens | - | - | Arrestin2 | 2.9 | 2025-11-19 | 10.1126/science.adt8794 |
|
A 2D representation of the interactions of TPO in 9UYN
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?1357 | R:R:C1358 | 4.05 | 7 | Yes | No | 6 | 5 | 2 | 1 | | R:R:?1357 | V:V:K11 | 9.59 | 7 | Yes | No | 6 | 9 | 2 | 2 | | R:R:?1357 | V:V:P14 | 5.59 | 7 | Yes | Yes | 6 | 6 | 2 | 2 | | R:R:?1359 | R:R:C1358 | 3.91 | 0 | No | No | 4 | 5 | 0 | 1 | | R:R:C1358 | V:V:P14 | 3.77 | 7 | No | Yes | 5 | 6 | 1 | 2 | | R:R:?1359 | R:R:?1360 | 19.6 | 0 | No | Yes | 4 | 6 | 0 | 1 | | R:R:?1360 | V:V:K11 | 12.74 | 7 | Yes | No | 6 | 9 | 1 | 2 | | R:R:?1360 | V:V:R25 | 5.99 | 7 | Yes | Yes | 6 | 9 | 1 | 2 | | R:R:?1360 | V:V:L166 | 4.55 | 7 | Yes | Yes | 6 | 8 | 1 | 2 | | R:R:?1360 | V:V:K294 | 9.26 | 7 | Yes | No | 6 | 9 | 1 | 2 | | V:V:K11 | V:V:L166 | 4.23 | 7 | No | Yes | 9 | 8 | 2 | 2 | | V:V:L166 | V:V:R25 | 6.07 | 7 | Yes | Yes | 8 | 9 | 2 | 2 | | R:R:?1360 | R:R:A1361 | 2.59 | 7 | Yes | No | 6 | 7 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 11.76 | | Average Nodes In Shell | 10.00 | | Average Hubs In Shell | 5.00 | | Average Links In Shell | 13.00 | | Average Links Mediated by Hubs In Shell | 12.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of TPO in 9UYN
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?1357 | R:R:C1358 | 4.05 | 7 | Yes | No | 6 | 5 | 2 | 2 | | R:R:?1357 | V:V:K11 | 9.59 | 7 | Yes | No | 6 | 9 | 2 | 1 | | R:R:?1359 | R:R:C1358 | 3.91 | 0 | No | No | 4 | 5 | 1 | 2 | | R:R:?1359 | R:R:?1360 | 19.6 | 0 | No | Yes | 4 | 6 | 1 | 0 | | R:R:?1360 | V:V:K11 | 12.74 | 7 | Yes | No | 6 | 9 | 0 | 1 | | R:R:?1360 | V:V:R25 | 5.99 | 7 | Yes | Yes | 6 | 9 | 0 | 1 | | R:R:?1360 | V:V:L166 | 4.55 | 7 | Yes | Yes | 6 | 8 | 0 | 1 | | R:R:?1360 | V:V:K294 | 9.26 | 7 | Yes | No | 6 | 9 | 0 | 1 | | V:V:F9 | V:V:R25 | 12.83 | 0 | No | Yes | 6 | 9 | 2 | 1 | | V:V:K11 | V:V:L166 | 4.23 | 7 | No | Yes | 9 | 8 | 1 | 1 | | V:V:L166 | V:V:L22 | 4.15 | 7 | Yes | No | 8 | 8 | 1 | 2 | | V:V:L166 | V:V:R25 | 6.07 | 7 | Yes | Yes | 8 | 9 | 1 | 1 | | V:V:L293 | V:V:R25 | 7.29 | 0 | No | Yes | 8 | 9 | 2 | 1 | | V:V:E296 | V:V:K294 | 5.4 | 0 | No | No | 7 | 9 | 2 | 1 | | R:R:?1362 | R:R:A1361 | 2.68 | 2 | Yes | No | 4 | 7 | 2 | 1 | | R:R:?1360 | R:R:A1361 | 2.59 | 7 | Yes | No | 6 | 7 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 6.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 9.12 | | Average Nodes In Shell | 14.00 | | Average Hubs In Shell | 5.00 | | Average Links In Shell | 16.00 | | Average Links Mediated by Hubs In Shell | 14.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 9WSV | A | Peptide | Opioid | MOP | Homo Sapiens | DAMGO | - | Arrestin2 | 2.8 | 2025-11-26 | 10.1038/s41422-025-01191-8 |
|
A 2D representation of the interactions of TPO in 9WSV
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?368 | R:R:C367 | 5.21 | 0 | No | No | 4 | 5 | 0 | 1 | | R:R:?368 | R:R:?369 | 20.53 | 0 | No | Yes | 4 | 6 | 0 | 1 | | R:R:?369 | V:V:K11 | 17.37 | 9 | Yes | Yes | 6 | 9 | 1 | 2 | | R:R:?369 | V:V:R25 | 13.97 | 9 | Yes | Yes | 6 | 9 | 1 | 2 | | R:R:?369 | V:V:L166 | 5.68 | 9 | Yes | Yes | 6 | 8 | 1 | 2 | | R:R:?369 | V:V:K294 | 9.26 | 9 | Yes | No | 6 | 8 | 1 | 2 | | V:V:K11 | V:V:L166 | 7.05 | 9 | Yes | Yes | 9 | 8 | 2 | 2 | | V:V:L166 | V:V:R25 | 4.86 | 9 | Yes | Yes | 8 | 9 | 2 | 2 | | V:V:K294 | V:V:R25 | 3.71 | 9 | No | Yes | 8 | 9 | 2 | 2 | | R:R:?369 | R:R:A370 | 2.59 | 9 | Yes | No | 6 | 7 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 12.87 | | Average Nodes In Shell | 8.00 | | Average Hubs In Shell | 4.00 | | Average Links In Shell | 10.00 | | Average Links Mediated by Hubs In Shell | 9.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of TPO in 9WSV
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?366 | V:V:K11 | 6 | 0 | No | Yes | 6 | 9 | 2 | 1 | | R:R:?368 | R:R:C367 | 5.21 | 0 | No | No | 4 | 5 | 1 | 2 | | R:R:?368 | R:R:?369 | 20.53 | 0 | No | Yes | 4 | 6 | 1 | 0 | | R:R:?369 | V:V:K11 | 17.37 | 9 | Yes | Yes | 6 | 9 | 0 | 1 | | R:R:?369 | V:V:R25 | 13.97 | 9 | Yes | Yes | 6 | 9 | 0 | 1 | | R:R:?369 | V:V:L166 | 5.68 | 9 | Yes | Yes | 6 | 8 | 0 | 1 | | R:R:?369 | V:V:K294 | 9.26 | 9 | Yes | No | 6 | 8 | 0 | 1 | | R:R:?371 | R:R:A370 | 4.02 | 3 | Yes | No | 4 | 7 | 2 | 1 | | V:V:F9 | V:V:R25 | 9.62 | 0 | No | Yes | 7 | 9 | 2 | 1 | | V:V:K11 | V:V:V164 | 4.55 | 9 | Yes | No | 9 | 8 | 1 | 2 | | V:V:K11 | V:V:L166 | 7.05 | 9 | Yes | Yes | 9 | 8 | 1 | 1 | | V:V:L166 | V:V:R25 | 4.86 | 9 | Yes | Yes | 8 | 9 | 1 | 1 | | V:V:L293 | V:V:R25 | 13.36 | 0 | No | Yes | 6 | 9 | 2 | 1 | | V:V:K294 | V:V:R25 | 3.71 | 9 | No | Yes | 8 | 9 | 1 | 1 | | V:V:L166 | V:V:L22 | 2.77 | 9 | Yes | No | 8 | 8 | 1 | 2 | | R:R:?369 | R:R:A370 | 2.59 | 9 | Yes | No | 6 | 7 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 6.00 | | Average Number Of Links With An Hub | 3.00 | | Average Interaction Strength | 11.57 | | Average Nodes In Shell | 14.00 | | Average Hubs In Shell | 5.00 | | Average Links In Shell | 16.00 | | Average Links Mediated by Hubs In Shell | 15.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 9WSX | A | Peptide | Opioid | MOP | Homo Sapiens | Endomorphin | - | Arrestin2 | 2.8 | 2025-11-26 | 10.1038/s41422-025-01191-8 |
|
A 2D representation of the interactions of TPO in 9WSX
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?366 | R:R:E365 | 2.25 | 3 | Yes | Yes | 6 | 3 | 1 | 2 | | R:R:?366 | R:R:C367 | 2.7 | 3 | Yes | No | 6 | 5 | 1 | 1 | | R:R:?366 | R:R:?368 | 1.93 | 3 | Yes | Yes | 6 | 4 | 1 | 0 | | R:R:?366 | V:V:K11 | 4.8 | 3 | Yes | Yes | 6 | 9 | 1 | 1 | | R:R:?366 | V:V:R165 | 12.4 | 3 | Yes | No | 6 | 5 | 1 | 2 | | R:R:?368 | R:R:C367 | 5.21 | 3 | Yes | No | 4 | 5 | 0 | 1 | | R:R:?368 | R:R:?369 | 20.53 | 3 | Yes | Yes | 4 | 6 | 0 | 1 | | R:R:?368 | V:V:K11 | 3.47 | 3 | Yes | Yes | 4 | 9 | 0 | 1 | | R:R:?369 | R:R:A370 | 2.59 | 3 | Yes | No | 6 | 7 | 1 | 2 | | R:R:?369 | V:V:K11 | 13.89 | 3 | Yes | Yes | 6 | 9 | 1 | 1 | | R:R:?369 | V:V:R25 | 11.97 | 3 | Yes | Yes | 6 | 9 | 1 | 2 | | R:R:?369 | V:V:L166 | 2.27 | 3 | Yes | No | 6 | 8 | 1 | 2 | | R:R:?369 | V:V:K294 | 8.11 | 3 | Yes | No | 6 | 8 | 1 | 2 | | V:V:K11 | V:V:L166 | 11.28 | 3 | Yes | No | 9 | 8 | 1 | 2 | | V:V:L166 | V:V:R25 | 4.86 | 3 | No | Yes | 8 | 9 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 4.00 | | Average Number Of Links With An Hub | 3.00 | | Average Interaction Strength | 7.79 | | Average Nodes In Shell | 11.00 | | Average Hubs In Shell | 6.00 | | Average Links In Shell | 15.00 | | Average Links Mediated by Hubs In Shell | 15.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of TPO in 9WSX
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?366 | R:R:C367 | 2.7 | 3 | Yes | No | 6 | 5 | 2 | 2 | | R:R:?366 | R:R:?368 | 1.93 | 3 | Yes | Yes | 6 | 4 | 2 | 1 | | R:R:?366 | V:V:K11 | 4.8 | 3 | Yes | Yes | 6 | 9 | 2 | 1 | | R:R:?368 | R:R:C367 | 5.21 | 3 | Yes | No | 4 | 5 | 1 | 2 | | R:R:?368 | R:R:?369 | 20.53 | 3 | Yes | Yes | 4 | 6 | 1 | 0 | | R:R:?368 | V:V:K11 | 3.47 | 3 | Yes | Yes | 4 | 9 | 1 | 1 | | R:R:?369 | R:R:A370 | 2.59 | 3 | Yes | No | 6 | 7 | 0 | 1 | | R:R:?369 | V:V:K11 | 13.89 | 3 | Yes | Yes | 6 | 9 | 0 | 1 | | R:R:?369 | V:V:R25 | 11.97 | 3 | Yes | Yes | 6 | 9 | 0 | 1 | | R:R:?369 | V:V:L166 | 2.27 | 3 | Yes | No | 6 | 8 | 0 | 1 | | R:R:?369 | V:V:K294 | 8.11 | 3 | Yes | No | 6 | 8 | 0 | 1 | | R:R:?371 | R:R:A370 | 4.02 | 4 | Yes | No | 4 | 7 | 2 | 1 | | V:V:F9 | V:V:R25 | 7.48 | 0 | No | Yes | 7 | 9 | 2 | 1 | | V:V:K11 | V:V:L166 | 11.28 | 3 | Yes | No | 9 | 8 | 1 | 1 | | V:V:L166 | V:V:R25 | 4.86 | 3 | No | Yes | 8 | 9 | 1 | 1 | | V:V:L293 | V:V:R25 | 19.44 | 0 | No | Yes | 6 | 9 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 6.00 | | Average Number Of Links With An Hub | 3.00 | | Average Interaction Strength | 9.89 | | Average Nodes In Shell | 12.00 | | Average Hubs In Shell | 6.00 | | Average Links In Shell | 16.00 | | Average Links Mediated by Hubs In Shell | 16.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 9KUV | A | Peptide | Apelin | Apelin | Homo sapiens | CMPD644 | - | Arrestin2 | 3.21 | 2025-09-17 | doi.org/10.1038/s41467-025-62870-z |
|
A 2D representation of the interactions of TPO in 9KUV
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?345 | R:R:C346 | 4.05 | 0 | Yes | No | 7 | 7 | 2 | 1 | | R:R:?345 | V:V:K11 | 8.39 | 0 | Yes | No | 7 | 9 | 2 | 2 | | R:R:?347 | R:R:C346 | 7.82 | 0 | No | No | 4 | 7 | 0 | 1 | | R:R:?347 | R:R:?348 | 20.53 | 0 | No | Yes | 4 | 6 | 0 | 1 | | R:R:?348 | V:V:K11 | 10.42 | 4 | Yes | No | 6 | 9 | 1 | 2 | | R:R:?348 | V:V:R25 | 12.97 | 4 | Yes | Yes | 6 | 9 | 1 | 2 | | R:R:?348 | V:V:L166 | 6.82 | 4 | Yes | Yes | 6 | 8 | 1 | 2 | | R:R:?348 | V:V:K294 | 8.11 | 4 | Yes | No | 6 | 9 | 1 | 2 | | V:V:K11 | V:V:L166 | 7.05 | 4 | No | Yes | 9 | 8 | 2 | 2 | | V:V:L166 | V:V:R25 | 3.64 | 4 | Yes | Yes | 8 | 9 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 14.18 | | Average Nodes In Shell | 8.00 | | Average Hubs In Shell | 4.00 | | Average Links In Shell | 10.00 | | Average Links Mediated by Hubs In Shell | 9.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of TPO in 9KUV
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?345 | R:R:C346 | 4.05 | 0 | Yes | No | 7 | 7 | 2 | 2 | | R:R:?345 | V:V:K11 | 8.39 | 0 | Yes | No | 7 | 9 | 2 | 1 | | R:R:?347 | R:R:C346 | 7.82 | 0 | No | No | 4 | 7 | 1 | 2 | | R:R:?347 | R:R:?348 | 20.53 | 0 | No | Yes | 4 | 6 | 1 | 0 | | R:R:?348 | V:V:K11 | 10.42 | 4 | Yes | No | 6 | 9 | 0 | 1 | | R:R:?348 | V:V:R25 | 12.97 | 4 | Yes | Yes | 6 | 9 | 0 | 1 | | R:R:?348 | V:V:L166 | 6.82 | 4 | Yes | Yes | 6 | 8 | 0 | 1 | | R:R:?348 | V:V:K294 | 8.11 | 4 | Yes | No | 6 | 9 | 0 | 1 | | V:V:F9 | V:V:R25 | 12.83 | 0 | No | Yes | 6 | 9 | 2 | 1 | | V:V:K11 | V:V:L166 | 7.05 | 4 | No | Yes | 9 | 8 | 1 | 1 | | V:V:L166 | V:V:V20 | 4.47 | 4 | Yes | No | 8 | 6 | 1 | 2 | | V:V:L166 | V:V:R25 | 3.64 | 4 | Yes | Yes | 8 | 9 | 1 | 1 | | V:V:L293 | V:V:R25 | 14.58 | 4 | Yes | Yes | 8 | 9 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 5.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 11.77 | | Average Nodes In Shell | 11.00 | | Average Hubs In Shell | 5.00 | | Average Links In Shell | 13.00 | | Average Links Mediated by Hubs In Shell | 12.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 9KUW | A | Peptide | Apelin | Apelin; Apelin | Homo sapiens | CMPD644 | - | Arrestin2 ; Arrestin2 | 3.49 | 2025-09-17 | doi.org/10.1038/s41467-025-62870-z |
|
A 2D representation of the interactions of TPO in 9KUW
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?345 | R:R:C346 | 4.05 | 1 | Yes | No | 7 | 7 | 1 | 1 | | R:R:?345 | R:R:?347 | 3.87 | 1 | Yes | Yes | 7 | 4 | 1 | 0 | | R:R:?345 | V:V:R161 | 5.17 | 1 | Yes | Yes | 7 | 7 | 1 | 2 | | R:R:?345 | V:V:R165 | 6.2 | 1 | Yes | No | 7 | 5 | 1 | 2 | | R:R:?347 | R:R:C346 | 7.82 | 1 | Yes | No | 4 | 7 | 0 | 1 | | R:R:C346 | V:V:K11 | 8.08 | 1 | No | Yes | 7 | 9 | 1 | 1 | | R:R:?347 | R:R:?348 | 23.33 | 1 | Yes | Yes | 4 | 6 | 0 | 1 | | R:R:?347 | V:V:K11 | 9.26 | 1 | Yes | Yes | 4 | 9 | 0 | 1 | | R:R:?348 | V:V:K11 | 18.53 | 1 | Yes | Yes | 6 | 9 | 1 | 1 | | R:R:?348 | V:V:R25 | 14.96 | 1 | Yes | Yes | 6 | 9 | 1 | 2 | | R:R:?348 | V:V:L166 | 4.55 | 1 | Yes | Yes | 6 | 8 | 1 | 2 | | R:R:?348 | V:V:K294 | 9.26 | 1 | Yes | No | 6 | 9 | 1 | 2 | | V:V:K11 | V:V:V20 | 3.04 | 1 | Yes | Yes | 9 | 6 | 1 | 2 | | V:V:K11 | V:V:L166 | 8.46 | 1 | Yes | Yes | 9 | 8 | 1 | 2 | | V:V:L166 | V:V:R25 | 8.5 | 1 | Yes | Yes | 8 | 9 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 4.00 | | Average Number Of Links With An Hub | 3.00 | | Average Interaction Strength | 11.07 | | Average Nodes In Shell | 11.00 | | Average Hubs In Shell | 8.00 | | Average Links In Shell | 15.00 | | Average Links Mediated by Hubs In Shell | 15.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of TPO in 9KUW
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?345 | R:R:C346 | 4.05 | 1 | Yes | No | 7 | 7 | 2 | 2 | | R:R:?345 | R:R:?347 | 3.87 | 1 | Yes | Yes | 7 | 4 | 2 | 1 | | R:R:?347 | R:R:C346 | 7.82 | 1 | Yes | No | 4 | 7 | 1 | 2 | | R:R:C346 | V:V:K11 | 8.08 | 1 | No | Yes | 7 | 9 | 2 | 1 | | R:R:?347 | R:R:?348 | 23.33 | 1 | Yes | Yes | 4 | 6 | 1 | 0 | | R:R:?347 | V:V:K11 | 9.26 | 1 | Yes | Yes | 4 | 9 | 1 | 1 | | R:R:?348 | V:V:K11 | 18.53 | 1 | Yes | Yes | 6 | 9 | 0 | 1 | | R:R:?348 | V:V:R25 | 14.96 | 1 | Yes | Yes | 6 | 9 | 0 | 1 | | R:R:?348 | V:V:L166 | 4.55 | 1 | Yes | Yes | 6 | 8 | 0 | 1 | | R:R:?348 | V:V:K294 | 9.26 | 1 | Yes | No | 6 | 9 | 0 | 1 | | V:V:F9 | V:V:R25 | 11.76 | 0 | No | Yes | 6 | 9 | 2 | 1 | | V:V:K11 | V:V:V20 | 3.04 | 1 | Yes | Yes | 9 | 6 | 1 | 2 | | V:V:K11 | V:V:L166 | 8.46 | 1 | Yes | Yes | 9 | 8 | 1 | 1 | | V:V:L22 | V:V:V20 | 2.98 | 0 | No | Yes | 8 | 6 | 2 | 2 | | V:V:L166 | V:V:L22 | 5.54 | 1 | Yes | No | 8 | 8 | 1 | 2 | | V:V:L166 | V:V:R25 | 8.5 | 1 | Yes | Yes | 8 | 9 | 1 | 1 | | V:V:L293 | V:V:R25 | 4.86 | 1 | Yes | Yes | 8 | 9 | 2 | 1 | | V:V:H362 | V:V:R25 | 3.39 | 1 | Yes | Yes | 1 | 9 | 2 | 1 | | V:V:K294 | V:V:L293 | 7.05 | 0 | No | Yes | 9 | 8 | 1 | 2 | | V:V:H362 | V:V:L293 | 7.71 | 1 | Yes | Yes | 1 | 8 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 5.00 | | Average Number Of Links With An Hub | 4.00 | | Average Interaction Strength | 14.13 | | Average Nodes In Shell | 13.00 | | Average Hubs In Shell | 9.00 | | Average Links In Shell | 20.00 | | Average Links Mediated by Hubs In Shell | 20.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of TPO in 9KUW
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:?345 | S:S:C346 | 6.75 | 13 | No | Yes | 7 | 7 | 1 | 1 | | S:S:?345 | S:S:?347 | 3.87 | 13 | No | Yes | 7 | 4 | 1 | 0 | | S:S:?345 | v:v:R165 | 7.23 | 13 | No | No | 7 | 5 | 1 | 2 | | S:S:?347 | S:S:C346 | 5.21 | 13 | Yes | Yes | 4 | 7 | 0 | 1 | | S:S:C346 | v:v:K11 | 6.47 | 13 | Yes | Yes | 7 | 9 | 1 | 1 | | S:S:C346 | v:v:A12 | 3.61 | 13 | Yes | No | 7 | 5 | 1 | 2 | | S:S:?347 | S:S:?348 | 28.93 | 13 | Yes | Yes | 4 | 6 | 0 | 1 | | S:S:?347 | v:v:K11 | 3.47 | 13 | Yes | Yes | 4 | 9 | 0 | 1 | | S:S:?348 | v:v:K11 | 9.26 | 13 | Yes | Yes | 6 | 9 | 1 | 1 | | S:S:?348 | v:v:R25 | 13.97 | 13 | Yes | No | 6 | 9 | 1 | 2 | | S:S:?348 | v:v:K294 | 10.42 | 13 | Yes | No | 6 | 9 | 1 | 2 | | v:v:K11 | v:v:V20 | 4.55 | 13 | Yes | No | 9 | 6 | 1 | 2 | | v:v:K11 | v:v:V164 | 6.07 | 13 | Yes | No | 9 | 8 | 1 | 2 | | v:v:V164 | v:v:V20 | 3.21 | 13 | No | No | 8 | 6 | 2 | 2 | | S:S:?348 | S:S:A349 | 2.59 | 13 | Yes | No | 6 | 7 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 4.00 | | Average Number Of Links With An Hub | 3.00 | | Average Interaction Strength | 10.37 | | Average Nodes In Shell | 12.00 | | Average Hubs In Shell | 4.00 | | Average Links In Shell | 15.00 | | Average Links Mediated by Hubs In Shell | 13.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of TPO in 9KUW
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:?345 | S:S:C346 | 6.75 | 13 | No | Yes | 7 | 7 | 2 | 2 | | S:S:?345 | S:S:?347 | 3.87 | 13 | No | Yes | 7 | 4 | 2 | 1 | | S:S:?347 | S:S:C346 | 5.21 | 13 | Yes | Yes | 4 | 7 | 1 | 2 | | S:S:C346 | v:v:K11 | 6.47 | 13 | Yes | Yes | 7 | 9 | 2 | 1 | | S:S:?347 | S:S:?348 | 28.93 | 13 | Yes | Yes | 4 | 6 | 1 | 0 | | S:S:?347 | v:v:K11 | 3.47 | 13 | Yes | Yes | 4 | 9 | 1 | 1 | | S:S:?348 | v:v:K11 | 9.26 | 13 | Yes | Yes | 6 | 9 | 0 | 1 | | S:S:?348 | v:v:R25 | 13.97 | 13 | Yes | No | 6 | 9 | 0 | 1 | | S:S:?348 | v:v:K294 | 10.42 | 13 | Yes | No | 6 | 9 | 0 | 1 | | S:S:?350 | S:S:A349 | 4.02 | 14 | No | No | 4 | 7 | 2 | 1 | | v:v:F9 | v:v:R25 | 7.48 | 0 | No | No | 6 | 9 | 2 | 1 | | v:v:K11 | v:v:V20 | 4.55 | 13 | Yes | No | 9 | 6 | 1 | 2 | | v:v:K11 | v:v:V164 | 6.07 | 13 | Yes | No | 9 | 8 | 1 | 2 | | v:v:V164 | v:v:V20 | 3.21 | 13 | No | No | 8 | 6 | 2 | 2 | | v:v:L166 | v:v:R25 | 7.29 | 0 | No | No | 8 | 9 | 2 | 1 | | S:S:?348 | S:S:A349 | 2.59 | 13 | Yes | No | 6 | 7 | 0 | 1 | | v:v:H295 | v:v:K294 | 1.31 | 0 | No | No | 7 | 9 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 5.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 13.03 | | Average Nodes In Shell | 14.00 | | Average Hubs In Shell | 4.00 | | Average Links In Shell | 17.00 | | Average Links Mediated by Hubs In Shell | 12.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 9KUX | A | Peptide | Apelin | Apelin; Apelin | Homo sapiens | CMPD644 | - | Arrestin2 | 3.57 | 2025-09-17 | doi.org/10.1038/s41467-025-62870-z |
|
A 2D representation of the interactions of TPO in 9KUX
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?345 | R:R:E344 | 9.01 | 2 | Yes | No | 7 | 7 | 1 | 2 | | R:R:?345 | R:R:C346 | 8.1 | 2 | Yes | No | 7 | 7 | 1 | 1 | | R:R:?345 | R:R:?347 | 1.93 | 2 | Yes | No | 7 | 4 | 1 | 0 | | R:R:?345 | V:V:K11 | 11.99 | 2 | Yes | No | 7 | 9 | 1 | 2 | | R:R:?345 | V:V:K160 | 2.4 | 2 | Yes | No | 7 | 8 | 1 | 2 | | R:R:?347 | R:R:C346 | 2.61 | 2 | No | No | 4 | 7 | 0 | 1 | | R:R:C346 | V:V:P14 | 1.88 | 2 | No | Yes | 7 | 6 | 1 | 2 | | R:R:?347 | R:R:?348 | 22.4 | 2 | No | Yes | 4 | 6 | 0 | 1 | | R:R:?348 | R:R:A349 | 2.59 | 2 | Yes | No | 6 | 7 | 1 | 2 | | R:R:?348 | V:V:F9 | 2 | 2 | Yes | No | 6 | 6 | 1 | 2 | | R:R:?348 | V:V:K11 | 3.47 | 2 | Yes | No | 6 | 9 | 1 | 2 | | R:R:?348 | V:V:R25 | 12.97 | 2 | Yes | Yes | 6 | 9 | 1 | 2 | | R:R:?348 | V:V:L293 | 2.27 | 2 | Yes | Yes | 6 | 8 | 1 | 2 | | R:R:?348 | V:V:K294 | 6.95 | 2 | Yes | No | 6 | 9 | 1 | 2 | | V:V:F9 | V:V:R25 | 8.55 | 2 | No | Yes | 6 | 9 | 2 | 2 | | V:V:L293 | V:V:R25 | 19.44 | 2 | Yes | Yes | 8 | 9 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 8.98 | | Average Nodes In Shell | 13.00 | | Average Hubs In Shell | 5.00 | | Average Links In Shell | 16.00 | | Average Links Mediated by Hubs In Shell | 15.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of TPO in 9KUX
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?345 | R:R:C346 | 8.1 | 2 | Yes | No | 7 | 7 | 2 | 2 | | R:R:?345 | R:R:?347 | 1.93 | 2 | Yes | No | 7 | 4 | 2 | 1 | | R:R:?345 | V:V:K11 | 11.99 | 2 | Yes | No | 7 | 9 | 2 | 1 | | R:R:?347 | R:R:C346 | 2.61 | 2 | No | No | 4 | 7 | 1 | 2 | | R:R:?347 | R:R:?348 | 22.4 | 2 | No | Yes | 4 | 6 | 1 | 0 | | R:R:?348 | R:R:A349 | 2.59 | 2 | Yes | No | 6 | 7 | 0 | 1 | | R:R:?348 | V:V:F9 | 2 | 2 | Yes | No | 6 | 6 | 0 | 1 | | R:R:?348 | V:V:K11 | 3.47 | 2 | Yes | No | 6 | 9 | 0 | 1 | | R:R:?348 | V:V:R25 | 12.97 | 2 | Yes | Yes | 6 | 9 | 0 | 1 | | R:R:?348 | V:V:L293 | 2.27 | 2 | Yes | Yes | 6 | 8 | 0 | 1 | | R:R:?348 | V:V:K294 | 6.95 | 2 | Yes | No | 6 | 9 | 0 | 1 | | R:R:?350 | R:R:A349 | 2.68 | 5 | No | No | 4 | 7 | 2 | 1 | | V:V:F9 | V:V:R25 | 8.55 | 2 | No | Yes | 6 | 9 | 1 | 1 | | V:V:K11 | V:V:L166 | 7.05 | 0 | No | No | 9 | 8 | 1 | 2 | | V:V:L293 | V:V:R25 | 19.44 | 2 | Yes | Yes | 8 | 9 | 1 | 1 | | V:V:H362 | V:V:R25 | 2.26 | 2 | Yes | Yes | 1 | 9 | 2 | 1 | | V:V:L293 | V:V:V167 | 2.98 | 2 | Yes | No | 8 | 5 | 1 | 2 | | V:V:E169 | V:V:L293 | 9.28 | 2 | Yes | Yes | 9 | 8 | 2 | 1 | | V:V:E169 | V:V:H362 | 6.15 | 2 | Yes | Yes | 9 | 1 | 2 | 2 | | V:V:H362 | V:V:L293 | 7.71 | 2 | Yes | Yes | 1 | 8 | 2 | 1 | | V:V:E296 | V:V:K294 | 5.4 | 0 | No | No | 7 | 9 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 7.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 7.52 | | Average Nodes In Shell | 16.00 | | Average Hubs In Shell | 6.00 | | Average Links In Shell | 21.00 | | Average Links Mediated by Hubs In Shell | 17.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
