psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C2	R:R:C282	7.28	No	No	0	6	1
2	R:R:G3	R:R:Y10	4.35	No	Yes	0	6	5
3	R:R:N15	R:R:T4	5.85	Yes	No	1	7	9
4	R:R:T4	R:R:V20	7.93	No	Yes	1	9	5
5	R:R:E5	R:R:Y10	3.37	No	Yes	0	6	5
6	R:R:G6	R:R:P7	4.06	No	No	0	6	5
7	R:R:F9	R:R:G6	6.02	Yes	No	0	7	6
8	R:R:N8	R:R:P7	3.26	No	No	0	7	5
9	R:R:F9	R:R:S22	6.61	Yes	Yes	1	7	7
10	R:R:F9	R:R:P23	15.89	Yes	Yes	1	7	5
11	R:R:F24	R:R:F9	3.22	Yes	Yes	1	5	7
12	R:R:Y10	R:R:Y192	5.96	Yes	Yes	1	5	4
13	R:R:T193	R:R:Y10	11.24	Yes	Yes	1	3	5
14	R:R:P12	R:R:V11	3.53	Yes	Yes	1	6	5
15	R:R:V11	R:R:V20	4.81	Yes	Yes	1	5	5
16	R:R:V11	R:R:Y30	3.79	Yes	Yes	1	5	4
17	R:R:L31	R:R:V11	4.47	Yes	Yes	1	4	5
18	R:R:L31	R:R:P12	3.28	Yes	Yes	1	4	6
19	R:R:P12	R:R:Q184	3.16	Yes	No	1	6	3
20	R:R:P12	R:R:P285	3.9	Yes	Yes	1	6	4
21	R:R:M288	R:R:P12	3.35	Yes	Yes	1	4	6
22	R:R:F13	R:R:Y30	6.19	No	Yes	1	4	4
23	R:R:F13	R:R:L31	3.65	No	Yes	1	4	4
24	R:R:G18	R:R:N15	3.39	No	Yes	1	6	7
25	R:R:N15	R:R:V20	10.35	Yes	Yes	1	7	5
26	H:H:?1	R:R:N15	24.5	Yes	Yes	1	0	7
27	R:R:T17	R:R:V19	6.35	No	No	0	5	5
28	H:H:?1	R:R:G18	4.58	Yes	No	1	0	6
29	R:R:V19	R:R:Y30	3.79	No	Yes	0	5	4
30	R:R:V20	R:R:Y30	8.83	Yes	Yes	1	5	4
31	H:H:?1	R:R:V20	5.32	Yes	Yes	1	0	5
32	R:R:R21	R:R:Y26	8.23	No	No	0	6	3
33	H:H:?1	R:R:R21	15.17	Yes	No	1	0	6
34	H:H:?2	R:R:R21	9.75	No	No	1	0	6
35	R:R:P23	R:R:S22	5.34	Yes	Yes	1	5	7
36	R:R:F24	R:R:S22	3.96	Yes	Yes	1	5	7
37	R:R:E25	R:R:S22	5.75	No	Yes	0	5	7
38	R:R:P23	R:R:Q28	6.32	Yes	No	0	5	6
39	R:R:P180	R:R:P23	3.9	Yes	Yes	1	1	5
40	R:R:P23	R:R:Q184	6.32	Yes	No	1	5	3
41	R:R:F24	R:R:G106	6.02	Yes	No	1	5	8
42	R:R:F24	R:R:P107	21.67	Yes	No	1	5	3
43	R:R:P27	R:R:Y26	4.17	No	No	0	9	3
44	R:R:P27	R:R:Y29	5.56	No	Yes	0	9	4
45	R:R:P27	R:R:Y102	6.95	No	No	0	9	5
46	R:R:Q28	R:R:Y30	11.27	No	Yes	0	6	4
47	R:R:P34	R:R:Y29	4.17	No	Yes	0	3	4
48	R:R:F37	R:R:Y29	8.25	No	Yes	14	3	4
49	R:R:G101	R:R:Y29	5.79	No	Yes	14	4	4
50	R:R:L31	R:R:Y30	4.69	Yes	Yes	1	4	4
51	R:R:L31	R:R:P285	3.28	Yes	Yes	1	4	4
52	R:R:A32	R:R:Q36	3.03	No	No	0	5	1
53	R:R:E33	R:R:W35	10.9	No	Yes	0	2	2
54	R:R:Q36	R:R:W35	15.33	No	Yes	0	1	2
55	R:R:M39	R:R:W35	3.49	No	Yes	0	4	2
56	R:R:I286	R:R:Q36	4.12	No	No	0	1	1
57	R:R:F37	R:R:G101	4.52	No	No	14	3	4
58	R:R:F37	R:R:L183	3.65	No	No	0	3	5
59	R:R:L40	R:R:M44	4.24	No	Yes	0	6	7
60	R:R:L40	R:R:S98	4.5	No	No	0	6	4
61	R:R:A41	R:R:S98	3.42	No	No	0	5	4
62	R:R:M44	R:R:Y43	3.59	Yes	Yes	8	7	4
63	R:R:L47	R:R:Y43	14.07	No	Yes	0	7	4
64	R:R:F293	R:R:Y43	13.41	No	Yes	8	4	4
65	R:R:S297	R:R:Y43	5.09	No	Yes	8	5	4
66	R:R:F91	R:R:M44	4.98	Yes	Yes	8	7	7
67	R:R:M44	R:R:T94	6.02	Yes	No	0	7	5
68	R:R:K296	R:R:M44	7.2	Yes	Yes	8	7	7
69	R:R:F45	R:R:V49	7.87	No	No	0	4	6
70	R:R:F45	R:R:L95	3.65	No	No	0	4	6
71	R:R:L46	R:R:L50	4.15	No	No	0	5	5
72	R:R:F91	R:R:L47	6.09	Yes	No	0	7	7
73	R:R:I48	R:R:V87	4.61	No	No	0	6	6
74	R:R:I48	R:R:T92	4.56	No	No	0	6	8
75	R:R:I300	R:R:L50	4.28	No	No	0	7	5
76	R:R:F52	R:R:P53	5.78	No	No	0	5	4
77	R:R:A80	R:R:N55	3.13	No	Yes	0	9	9
78	R:R:D83	R:R:N55	10.77	No	Yes	15	9	9
79	R:R:L84	R:R:N55	4.12	No	Yes	0	8	9
80	R:R:N55	R:R:P303	8.15	Yes	No	15	9	9
81	R:R:A80	R:R:T58	5.03	No	No	0	9	9
82	R:R:I307	R:R:T58	7.6	No	No	0	6	9
83	R:R:M317	R:R:T58	3.01	No	No	0	6	9
84	R:R:A80	R:R:L59	4.73	No	No	0	9	8
85	R:R:L59	R:R:V81	2.98	No	No	0	8	7
86	R:R:Q64	R:R:Y60	7.89	No	No	0	6	3
87	R:R:T320	R:R:V61	7.93	No	No	0	5	8
88	R:R:L68	R:R:T62	5.9	Yes	No	0	8	7
89	R:R:L77	R:R:T62	5.9	No	No	0	6	7
90	R:R:L68	R:R:Q312	5.32	Yes	Yes	0	8	7
91	R:R:F313	R:R:L68	4.87	Yes	Yes	0	8	8
92	R:R:C316	R:R:L68	7.94	No	Yes	0	6	8
93	R:R:P71	R:R:T70	3.5	No	No	0	6	7
94	R:R:T70	V:V:I73	6.08	No	Yes	0	7	8
95	R:R:L72	R:R:V138	2.98	No	No	0	8	8
96	R:R:F148	R:R:L72	8.53	Yes	No	0	6	8
97	R:R:L72	V:V:I73	7.14	No	Yes	0	8	8
98	R:R:F313	R:R:N73	9.67	Yes	No	2	8	8
99	R:R:N73	V:V:I73	7.08	No	Yes	0	8	8
100	R:R:N73	V:V:M76	4.21	No	Yes	2	8	7
101	R:R:E150	R:R:Y74	6.73	No	No	0	1	5
102	R:R:A153	R:R:Y74	5.34	No	No	0	7	5
103	R:R:I75	R:R:S127	4.64	Yes	Yes	2	7	7
104	R:R:I75	R:R:V130	7.68	Yes	No	2	7	7
105	R:R:I75	R:R:L131	5.71	Yes	Yes	2	7	9
106	R:R:E134	R:R:I75	6.83	No	Yes	2	8	7
107	R:R:L131	R:R:L76	6.92	Yes	No	0	9	8
108	R:R:F313	R:R:L76	3.65	Yes	No	0	8	8
109	R:R:I123	R:R:N78	4.25	Yes	Yes	2	7	9
110	R:R:N78	R:R:S127	5.96	Yes	Yes	2	9	7
111	R:R:N78	R:R:V157	8.87	Yes	No	0	9	7
112	R:R:N78	R:R:T160	4.39	Yes	Yes	2	9	6
113	R:R:N78	R:R:W161	9.04	Yes	No	2	9	9
114	R:R:D83	R:R:L79	4.07	No	No	0	9	9
115	R:R:L79	R:R:S127	3	No	Yes	0	9	7
116	R:R:L128	R:R:L79	4.15	No	No	0	9	9
117	R:R:F85	R:R:V81	3.93	No	No	0	6	7
118	R:R:A82	R:R:I123	3.25	No	Yes	0	8	7
119	R:R:D83	R:R:P303	9.66	No	No	15	9	9
120	R:R:F91	R:R:M86	6.22	Yes	No	0	7	7
121	R:R:G121	R:R:M86	3.49	No	No	0	7	7
122	R:R:F91	R:R:V87	3.93	Yes	No	0	7	6
123	R:R:F116	R:R:G89	4.52	No	No	0	4	5
124	R:R:F91	R:R:K296	6.2	Yes	Yes	8	7	7
125	R:R:Q113	R:R:S93	5.78	No	No	0	5	5
126	R:R:Q113	R:R:T94	8.5	No	No	0	5	5
127	R:R:S186	R:R:T94	7.99	No	No	0	4	5
128	R:R:H100	R:R:Y96	10.89	No	No	0	4	3
129	R:R:F105	R:R:Y96	8.25	No	No	0	6	3
130	R:R:F103	R:R:T97	6.49	Yes	No	0	8	5
131	R:R:C185	R:R:T97	3.38	No	No	0	5	5
132	R:R:H100	R:R:V104	4.15	No	No	0	4	3
133	R:R:V104	R:R:Y102	3.79	No	No	0	3	5
134	R:R:C110	R:R:F103	4.19	No	Yes	1	9	8
135	R:R:F103	R:R:Q113	8.2	Yes	No	0	8	5
136	R:R:C187	R:R:F103	11.17	No	Yes	1	9	8
137	R:R:G106	R:R:P107	4.06	No	No	1	8	3
138	R:R:C110	R:R:P180	3.77	No	Yes	1	9	1
139	R:R:C110	R:R:C187	7.28	No	No	1	9	9
140	R:R:L172	R:R:N111	4.12	No	No	0	5	7
141	R:R:G114	R:R:Y178	4.35	No	Yes	0	5	5
142	R:R:F115	R:R:F116	4.29	No	No	0	6	4
143	R:R:F115	R:R:Y178	5.16	No	Yes	0	6	5
144	R:R:C167	R:R:T118	3.38	No	Yes	0	5	5
145	R:R:A168	R:R:T118	3.36	No	Yes	0	7	5
146	R:R:T118	R:R:Y178	9.99	Yes	Yes	0	5	5
147	R:R:I189	R:R:T118	3.04	No	Yes	0	4	5
148	R:R:I123	R:R:L119	7.14	Yes	No	0	7	5
149	R:R:A168	R:R:L119	3.15	No	No	0	7	5
150	R:R:E122	R:R:L125	5.3	Yes	No	0	6	7
151	R:R:E122	R:R:W126	7.63	Yes	Yes	2	6	6
152	R:R:A164	R:R:E122	3.02	No	Yes	0	8	6
153	R:R:C167	R:R:E122	12.15	No	Yes	2	5	6
154	R:R:E122	R:R:H211	14.77	Yes	Yes	2	6	6
155	R:R:I123	R:R:T160	3.04	Yes	Yes	2	7	6
156	R:R:I123	R:R:W161	8.22	Yes	No	2	7	9
157	R:R:A164	R:R:I123	4.87	No	Yes	0	8	7
158	R:R:L125	R:R:P215	9.85	No	Yes	0	7	8
159	R:R:L125	R:R:W265	11.39	No	No	0	7	8
160	R:R:V129	R:R:W126	8.58	Yes	Yes	2	7	6
161	R:R:T160	R:R:W126	3.64	Yes	Yes	2	6	6
162	R:R:M163	R:R:W126	13.96	No	Yes	0	4	6
163	R:R:H211	R:R:W126	4.23	Yes	Yes	2	6	6
164	R:R:P215	R:R:W126	12.16	Yes	Yes	2	8	6
165	R:R:S127	R:R:T160	3.2	Yes	Yes	2	7	6
166	R:R:L128	R:R:Y306	19.93	No	Yes	0	9	9
167	R:R:P215	R:R:V129	3.53	Yes	Yes	2	8	7
168	R:R:I218	R:R:V129	4.61	No	Yes	0	6	7
169	R:R:I219	R:R:V129	4.61	No	Yes	0	8	7
170	R:R:E134	R:R:V130	5.7	No	No	2	8	7
171	R:R:L131	R:R:R135	14.58	Yes	Yes	2	9	9
172	R:R:L131	R:R:Y223	3.52	Yes	Yes	2	9	9
173	R:R:L131	R:R:Y306	3.52	Yes	Yes	0	9	9
174	R:R:A132	R:R:C222	3.61	No	No	0	9	7
175	R:R:A132	R:R:Y223	6.67	No	Yes	0	9	9
176	R:R:C222	R:R:I133	3.27	No	No	0	7	6
177	R:R:E134	R:R:F148	8.16	No	Yes	0	8	6
178	R:R:R135	R:R:Y223	3.09	Yes	Yes	2	9	9
179	R:R:R135	R:R:Y257	6.17	Yes	Yes	2	9	8
180	R:R:N310	R:R:R135	4.82	No	Yes	2	8	9
181	R:R:Q225	R:R:Y136	4.51	No	No	0	5	8
182	R:R:S144	R:R:V137	3.23	No	No	0	4	5
183	R:R:N145	R:R:V138	5.91	No	No	0	5	8
184	R:R:V139	V:V:T79	3.17	No	No	0	8	6
185	R:R:V139	V:V:Y251	3.79	No	Yes	0	8	7
186	R:R:C140	R:R:T229	5.07	No	No	0	7	5
187	R:R:K141	V:V:S252	3.06	No	No	17	6	8
188	R:R:K141	V:V:D254	12.44	No	No	17	6	8
189	R:R:P142	V:V:F66	4.33	Yes	Yes	3	7	9
190	R:R:P142	V:V:Y68	5.56	Yes	Yes	3	7	9
191	R:R:P142	V:V:V248	3.53	Yes	No	0	7	8
192	R:R:P142	V:V:L250	6.57	Yes	Yes	3	7	8
193	R:R:M143	V:V:Y256	19.16	No	No	0	5	7
194	R:R:N145	V:V:Y68	4.65	No	Yes	0	5	9
195	R:R:N145	V:V:G69	3.39	No	No	0	5	9
196	R:R:F146	V:V:L133	4.87	No	No	3	4	7
197	R:R:F146	V:V:C144	4.19	No	No	3	4	8
198	R:R:F148	R:R:H152	5.66	Yes	No	0	6	5
199	R:R:G149	V:V:K142	3.49	No	No	0	7	8
200	R:R:F159	R:R:M163	8.71	No	No	0	3	4
201	R:R:C167	R:R:H211	7.37	No	Yes	2	5	6
202	R:R:P170	R:R:P171	5.84	No	No	0	7	5
203	R:R:P170	R:R:W175	4.05	No	Yes	0	7	4
204	R:R:P171	R:R:Y178	18.08	No	Yes	0	5	5
205	R:R:F203	R:R:P171	5.78	Yes	No	0	6	5
206	R:R:S202	R:R:W175	8.65	No	Yes	0	5	4
207	R:R:F203	R:R:W175	13.03	Yes	Yes	0	6	4
208	R:R:W175	R:R:Y206	8.68	Yes	No	0	4	3
209	R:R:N200	R:R:S176	7.45	Yes	No	0	5	5
210	R:R:F203	R:R:S176	10.57	Yes	No	0	6	5
211	R:R:I179	R:R:R177	10.02	Yes	No	1	3	4
212	R:R:D190	R:R:R177	11.91	Yes	No	1	4	4
213	R:R:R177	R:R:T193	3.88	No	Yes	1	4	3
214	R:R:I179	R:R:P180	3.39	Yes	Yes	1	3	1
215	R:R:D190	R:R:I179	9.8	Yes	Yes	1	4	3
216	R:R:I179	R:R:Y192	7.25	Yes	Yes	1	3	4
217	R:R:P180	R:R:Q184	9.47	Yes	No	1	1	3
218	R:R:C187	R:R:P180	5.65	No	Yes	1	9	1
219	R:R:E181	R:R:G188	3.27	Yes	No	0	3	5
220	R:R:E181	R:R:Y191	4.49	Yes	Yes	1	3	5
221	R:R:E181	R:R:Y192	3.37	Yes	Yes	1	3	4
222	R:R:E181	R:R:Y268	4.49	Yes	Yes	1	3	6
223	R:R:G182	R:R:M288	3.49	No	Yes	0	2	4
224	R:R:L183	R:R:P285	3.28	No	Yes	0	5	4
225	R:R:K296	R:R:S186	4.59	Yes	No	0	7	4
226	R:R:F203	R:R:I189	3.77	Yes	No	16	6	4
227	R:R:I189	R:R:M207	4.37	No	No	16	4	5
228	R:R:D190	R:R:Y192	6.9	Yes	Yes	1	4	4
229	R:R:D190	R:R:T193	10.12	Yes	Yes	1	4	3
230	R:R:D190	R:R:N200	10.77	Yes	Yes	1	4	5
231	R:R:Y191	R:R:Y192	7.94	Yes	Yes	1	5	4
232	R:R:Y191	R:R:Y268	3.97	Yes	Yes	1	5	6
233	R:R:A272	R:R:Y191	4	No	Yes	0	5	5
234	R:R:M288	R:R:Y191	5.99	Yes	Yes	1	4	5
235	R:R:T193	R:R:Y192	4.99	Yes	Yes	1	3	4
236	R:R:M288	R:R:Y192	7.18	Yes	Yes	1	4	4
237	R:R:K195	R:R:P196	5.02	Yes	No	0	4	3
238	R:R:E197	R:R:K195	12.15	No	Yes	0	2	4
239	R:R:K195	R:R:V198	3.04	Yes	No	1	4	1
240	R:R:K195	R:R:N200	4.2	Yes	Yes	1	4	5
241	R:R:N200	R:R:V198	4.43	Yes	No	1	5	1
242	R:R:F203	R:R:M207	3.73	Yes	No	16	6	5
243	R:R:V210	R:R:Y206	7.57	No	No	2	4	3
244	R:R:H211	R:R:Y206	13.07	Yes	No	2	6	3
245	R:R:F208	R:R:F273	4.29	No	No	0	6	5
246	R:R:H211	R:R:V210	11.07	Yes	No	2	6	4
247	R:R:F212	R:R:M216	3.73	No	No	0	8	6
248	R:R:A269	R:R:F212	8.32	No	No	0	8	8
249	R:R:I217	R:R:T213	3.04	No	No	0	3	4
250	R:R:I214	R:R:P215	3.39	No	Yes	0	5	8
251	R:R:F220	R:R:M216	4.98	Yes	No	10	4	6
252	R:R:F261	R:R:M216	4.98	No	No	10	9	6
253	R:R:F220	R:R:V258	6.55	Yes	No	10	4	8
254	R:R:F220	R:R:F261	3.22	Yes	No	10	4	9
255	R:R:F220	R:R:L262	3.65	Yes	No	10	4	5
256	R:R:F221	R:R:Q225	8.2	No	No	0	4	5
257	R:R:Y223	R:R:Y257	7.94	Yes	Yes	2	9	8
258	R:R:V227	R:R:V254	4.81	No	No	0	5	8
259	R:R:T229	V:V:Y251	3.75	No	Yes	0	5	7
260	R:R:A233	V:V:R82	5.53	No	Yes	0	6	9
261	R:R:A234	R:R:Q244	4.55	No	No	0	4	3
262	R:R:A234	R:R:E247	3.02	No	No	0	4	7
263	R:R:Q236	V:V:R82	5.84	No	Yes	0	3	9
264	R:R:Q237	V:V:R82	16.35	No	Yes	3	5	9
265	R:R:Q237	V:V:M322	5.44	No	No	3	5	5
266	R:R:E239	V:V:R319	6.98	No	No	0	2	5
267	R:R:S240	R:R:T242	4.8	No	No	0	3	4
268	R:R:S240	R:R:T243	9.59	No	No	0	3	4
269	R:R:T242	V:V:F80	5.19	No	Yes	0	4	9
270	R:R:Q244	R:R:T243	4.25	No	No	0	3	4
271	R:R:K245	V:V:D163	6.91	No	No	0	5	6
272	R:R:E247	R:R:T251	4.23	No	No	0	7	6
273	R:R:V250	V:V:L78	5.96	No	No	0	8	6
274	R:R:M253	R:R:Y257	8.38	No	Yes	0	8	8
275	R:R:M253	R:R:M309	5.78	No	No	0	8	7
276	R:R:M253	V:V:L78	5.65	No	No	0	8	6
277	R:R:I256	R:R:I305	5.89	No	No	0	5	8
278	R:R:Y257	R:R:Y306	22.84	Yes	Yes	0	8	9
279	R:R:L262	R:R:V258	2.98	No	No	10	5	8
280	R:R:A260	R:R:I305	3.25	No	No	0	7	8
281	R:R:F261	R:R:W265	5.01	No	No	0	9	8
282	R:R:L262	R:R:V266	2.98	No	No	0	5	5
283	R:R:F294	R:R:I263	5.02	No	No	0	7	6
284	R:R:I263	R:R:Y301	4.84	No	Yes	0	6	5
285	R:R:C264	R:R:W265	11.75	No	No	0	9	8
286	R:R:A298	R:R:C264	3.61	No	No	11	9	9
287	R:R:C264	R:R:Y301	4.03	No	Yes	11	9	5
288	R:R:P267	R:R:V266	3.53	No	No	0	9	5
289	R:R:P267	R:R:P291	3.9	No	Yes	0	9	7
290	R:R:F294	R:R:P267	7.22	No	No	0	7	9
291	R:R:P291	R:R:Y268	6.95	Yes	Yes	0	7	6
292	R:R:A295	R:R:Y268	4	No	Yes	0	7	6
293	R:R:I275	R:R:V271	3.07	No	No	12	5	5
294	R:R:F287	R:R:V271	6.55	No	No	12	5	5
295	R:R:P291	R:R:V271	7.07	Yes	No	0	7	5
296	R:R:F273	R:R:T277	5.19	No	No	0	5	4
297	R:R:H278	R:R:Y274	25.04	No	No	0	3	3
298	R:R:F283	R:R:Y274	4.13	Yes	No	0	2	3
299	R:R:F283	R:R:I275	7.54	Yes	No	12	2	5
300	R:R:F287	R:R:I275	3.77	No	No	12	5	5
301	R:R:H278	R:R:T277	5.48	No	No	0	3	4
302	R:R:F283	R:R:S281	5.28	Yes	No	0	2	2
303	R:R:F283	R:R:F287	13.93	Yes	No	12	2	5
304	R:R:G284	R:R:P285	4.06	No	Yes	0	3	4
305	R:R:I286	R:R:P285	3.39	No	Yes	0	1	4
306	R:R:I290	R:R:P291	3.39	No	Yes	0	5	7
307	R:R:A292	R:R:K296	3.21	No	Yes	0	5	7
308	R:R:F293	R:R:F294	11.79	No	No	0	4	7
309	R:R:F293	R:R:S297	7.93	No	No	8	4	5
310	R:R:A298	R:R:Y301	5.34	No	Yes	11	9	5
311	R:R:A298	R:R:N302	4.69	No	No	11	9	9
312	R:R:N302	R:R:Y301	6.98	No	Yes	11	9	5
313	R:R:M308	R:R:V304	7.61	No	No	0	6	6
314	R:R:I305	R:R:Y306	3.63	No	Yes	0	8	9
315	R:R:F313	R:R:I307	6.28	Yes	No	0	8	6
316	R:R:F313	R:R:N310	4.83	Yes	No	2	8	8
317	R:R:N310	V:V:M76	9.82	No	Yes	2	8	7
318	R:R:K311	R:R:R314	6.19	No	No	0	4	8
319	R:R:Q312	V:V:D72	7.83	Yes	No	0	7	9
320	R:R:Q312	V:V:M76	12.23	Yes	Yes	0	7	7
321	R:R:F313	V:V:M76	6.22	Yes	Yes	2	8	7
322	R:R:N315	R:R:R314	6.03	No	No	0	4	8
323	R:R:C322	R:R:L318	3.17	No	No	0	6	5
324	R:R:D330	V:V:R19	4.76	No	Yes	18	4	5
325	R:R:D330	V:V:K167	15.21	No	No	18	4	7
326	R:R:A333	V:V:R19	4.15	No	Yes	0	4	5
327	R:R:?336	R:R:V337	7.33	Yes	No	0	6	5
328	R:R:?336	V:V:K16	15.03	Yes	No	0	6	9
329	R:R:?336	V:V:R19	2.99	Yes	Yes	0	6	5
330	R:R:?336	V:V:R172	4.98	Yes	No	0	6	5
331	R:R:?338	R:R:V337	8.85	Yes	No	9	8	5
332	R:R:K339	R:R:V337	4.55	No	No	9	5	5
333	R:R:?338	R:R:K339	7.18	Yes	No	9	8	5
334	R:R:?338	V:V:K16	4.79	Yes	No	0	8	9
335	R:R:?338	V:V:R30	8.25	Yes	Yes	9	8	9
336	R:R:?338	V:V:K301	8.38	Yes	No	0	8	9
337	R:R:T340	V:V:F14	3.89	No	No	0	7	6
338	R:R:T342	V:V:V12	4.76	No	No	0	5	5
339	R:R:S343	V:V:K111	9.18	No	No	0	8	9
340	V:V:F14	V:V:R30	7.48	No	Yes	9	6	9
341	V:V:F14	V:V:L173	3.65	No	No	9	6	8
342	V:V:K15	V:V:Y26	11.94	No	Yes	0	8	8
343	V:V:K16	V:V:V171	6.07	No	Yes	0	9	7
344	V:V:K21	V:V:V17	3.04	No	No	0	5	4
345	V:V:T24	V:V:V17	6.35	No	No	0	7	4
346	V:V:D20	V:V:S18	4.42	Yes	No	0	8	8
347	V:V:S18	V:V:V171	3.23	No	Yes	0	8	7
348	V:V:K167	V:V:R19	7.43	No	Yes	18	7	5
349	V:V:D20	V:V:S22	8.83	Yes	Yes	0	8	5
350	V:V:D20	V:V:S169	4.42	Yes	No	0	8	8
351	V:V:S22	V:V:V23	4.85	Yes	No	0	5	5
352	V:V:L52	V:V:S22	4.5	No	Yes	0	4	5
353	V:V:S22	V:V:V53	3.23	Yes	Yes	0	5	4
354	V:V:V23	V:V:V58	3.21	No	Yes	0	5	7
355	V:V:T24	V:V:Y26	6.24	No	Yes	0	7	8
356	V:V:F119	V:V:I25	3.77	Yes	No	0	9	5
357	V:V:I25	V:V:V171	4.61	No	Yes	0	5	7
358	V:V:V45	V:V:Y26	3.79	No	Yes	0	7	8
359	V:V:L112	V:V:Y26	14.07	No	Yes	0	7	8
360	V:V:L27	V:V:Y32	3.52	Yes	Yes	7	8	7
361	V:V:L27	V:V:V42	2.98	Yes	Yes	7	8	7
362	V:V:L27	V:V:V150	4.47	Yes	No	7	8	6
363	V:V:K29	V:V:Y32	4.78	No	Yes	0	8	7
364	V:V:E40	V:V:K29	8.1	No	No	0	6	8
365	V:V:L173	V:V:R30	6.07	No	Yes	9	8	9
366	V:V:I300	V:V:R30	7.52	No	Yes	0	7	9
367	V:V:D31	V:V:R176	14.29	No	Yes	0	9	9
368	V:V:V42	V:V:Y32	11.36	Yes	Yes	7	7	7
369	V:V:D43	V:V:Y32	3.45	No	Yes	0	7	7
370	V:V:I175	V:V:Y32	6.04	No	Yes	0	8	7
371	V:V:H35	V:V:V33	5.54	No	No	0	6	8
372	V:V:H180	V:V:V33	4.15	No	No	0	4	8
373	V:V:D34	V:V:V39	7.3	No	No	5	9	7
374	V:V:D34	V:V:K177	17.97	No	Yes	5	9	9
375	V:V:D34	V:V:Q179	9.14	No	No	0	9	9
376	V:V:F123	V:V:V39	10.49	No	No	0	5	7
377	V:V:K177	V:V:V39	4.55	Yes	No	5	9	7
378	V:V:E40	V:V:P41	3.14	No	No	0	6	5
379	V:V:L120	V:V:P41	4.93	No	No	0	4	5
380	V:V:L121	V:V:V42	5.96	Yes	Yes	7	7	7
381	V:V:V150	V:V:V42	3.21	No	Yes	7	6	7
382	V:V:D43	V:V:L104	6.79	No	Yes	0	7	5
383	V:V:F119	V:V:G44	4.52	Yes	No	0	9	8
384	V:V:L108	V:V:V45	7.45	No	No	0	9	7
385	V:V:T116	V:V:V45	4.76	Yes	No	0	8	7
386	V:V:V46	V:V:V91	3.21	No	No	0	4	5
387	V:V:L47	V:V:T116	5.9	No	Yes	0	5	8
388	V:V:V48	V:V:V53	4.81	No	Yes	0	4	4
389	V:V:V48	V:V:V58	6.41	No	Yes	0	4	7
390	V:V:D49	V:V:P50	6.44	No	No	0	8	4
391	V:V:D49	V:V:L52	13.57	No	No	0	8	4
392	V:V:N115	V:V:P50	13.03	No	No	0	6	4
393	V:V:K56	V:V:V53	4.55	No	Yes	0	5	4
394	V:V:A154	V:V:V53	3.39	No	Yes	0	6	4
395	V:V:D156	V:V:K56	9.68	No	No	0	3	5
396	V:V:K57	V:V:Y59	9.55	No	Yes	0	5	4
397	V:V:V58	V:V:V91	4.81	Yes	No	0	7	5
398	V:V:V58	V:V:Y92	5.05	Yes	No	0	7	4
399	V:V:R88	V:V:Y59	9.26	Yes	Yes	4	4	4
400	V:V:Q90	V:V:Y59	5.64	No	Yes	0	9	4
401	V:V:F153	V:V:Y59	7.22	No	Yes	0	6	4
402	V:V:D159	V:V:Y59	12.64	No	Yes	4	3	4
403	V:V:V60	V:V:V91	3.21	No	No	0	7	5
404	V:V:F119	V:V:V60	11.8	Yes	No	7	9	7
405	V:V:L121	V:V:V60	2.98	Yes	No	7	7	7
406	V:V:T61	V:V:T63	3.14	Yes	Yes	4	6	7
407	V:V:F86	V:V:T61	6.49	Yes	Yes	4	4	6
408	V:V:R88	V:V:T61	3.88	Yes	Yes	4	4	6
409	V:V:K151	V:V:T61	6.01	Yes	Yes	4	8	6
410	V:V:E162	V:V:T61	4.23	No	Yes	4	5	6
411	V:V:L121	V:V:L62	6.92	Yes	No	0	7	6
412	V:V:F123	V:V:L62	10.96	No	No	0	5	6
413	V:V:F86	V:V:T63	6.49	Yes	Yes	4	4	7
414	V:V:K151	V:V:T63	3	Yes	Yes	4	8	7
415	V:V:C64	V:V:L84	6.35	No	No	0	9	8
416	V:V:C64	V:V:F148	9.78	No	Yes	0	9	7
417	V:V:F66	V:V:L84	4.87	Yes	No	0	9	8
418	V:V:F66	V:V:V146	5.24	Yes	No	3	9	9
419	V:V:F66	V:V:L250	7.31	Yes	Yes	3	9	8
420	V:V:F66	V:V:G323	3.01	Yes	No	0	9	9
421	V:V:F66	V:V:I324	5.02	Yes	Yes	3	9	8
422	V:V:E71	V:V:R67	5.82	No	No	0	7	8
423	V:V:D147	V:V:R67	15.48	No	No	0	7	8
424	V:V:D74	V:V:Y68	5.75	No	Yes	0	9	9
425	V:V:L250	V:V:Y68	3.52	Yes	Yes	3	8	9
426	V:V:Y251	V:V:Y68	2.98	Yes	Yes	3	7	9
427	V:V:D74	V:V:G69	3.35	No	No	0	9	9
428	V:V:F80	V:V:V75	3.93	Yes	No	0	9	9
429	V:V:D83	V:V:R81	5.96	No	No	0	8	8
430	V:V:L250	V:V:R82	3.64	Yes	Yes	3	8	9
431	V:V:M322	V:V:R82	7.44	No	Yes	3	5	9
432	V:V:S87	V:V:Y85	6.36	No	Yes	0	4	4
433	V:V:P124	V:V:Y85	18.08	No	Yes	5	6	4
434	V:V:Y126	V:V:Y85	3.97	Yes	Yes	5	5	4
435	V:V:L127	V:V:Y85	7.03	No	Yes	5	7	4
436	V:V:F86	V:V:R88	6.41	Yes	Yes	4	4	4
437	V:V:E162	V:V:F86	12.83	No	Yes	4	5	4
438	V:V:D159	V:V:R88	11.91	No	Yes	4	3	4
439	V:V:E162	V:V:R88	5.82	No	Yes	4	5	4
440	V:V:L121	V:V:V89	2.98	Yes	No	0	7	3
441	V:V:P93	V:V:Q90	3.16	No	No	0	9	9
442	V:V:P93	V:V:Y92	8.34	No	No	0	9	4
443	V:V:Y117	V:V:Y92	8.94	No	No	0	3	4
444	V:V:P94	V:V:Y117	8.34	No	No	0	4	3
445	V:V:L101	V:V:Q105	7.99	No	No	20	3	9
446	V:V:L101	V:V:P118	3.28	No	No	20	3	8
447	V:V:Q105	V:V:T102	8.5	No	No	0	9	7
448	V:V:L104	V:V:L108	6.92	Yes	No	19	5	9
449	V:V:P118	V:V:Q105	6.32	No	No	20	8	9
450	V:V:L112	V:V:T116	8.84	No	Yes	0	7	8
451	V:V:D114	V:V:N115	13.46	No	No	0	2	6
452	V:V:F119	V:V:L121	4.87	Yes	Yes	7	9	7
453	V:V:F123	V:V:F148	3.22	No	Yes	0	5	7
454	V:V:P124	V:V:Y126	13.91	No	Yes	5	6	5
455	V:V:L127	V:V:P124	4.93	No	No	5	7	6
456	V:V:D125	V:V:K314	8.3	No	No	5	5	5
457	V:V:D125	V:V:I317	4.2	No	No	5	5	4
458	V:V:R319	V:V:Y126	7.2	No	Yes	0	5	5
459	V:V:P128	V:V:V321	3.53	No	No	0	9	5
460	V:V:G323	V:V:P128	4.06	No	No	0	9	9
461	V:V:C129	V:V:Q179	7.63	No	No	0	7	9
462	V:V:C129	V:V:T311	3.38	No	No	0	7	9
463	V:V:F148	V:V:S130	5.28	Yes	No	0	7	9
464	V:V:R176	V:V:S130	5.27	Yes	No	0	9	9
465	V:V:I324	V:V:V131	9.22	Yes	No	0	8	9
466	V:V:G298	V:V:M132	3.49	No	No	0	9	5
467	V:V:K299	V:V:M132	5.76	No	No	0	5	5
468	V:V:C144	V:V:L133	4.76	No	No	3	8	7
469	V:V:P135	V:V:Q134	3.16	No	Yes	0	8	8
470	V:V:L285	V:V:Q134	3.99	Yes	Yes	21	8	8
471	V:V:I294	V:V:Q134	6.86	No	Yes	0	7	8
472	V:V:L296	V:V:Q134	9.32	No	Yes	21	8	8
473	V:V:A136	V:V:Q138	6.06	No	No	22	5	4
474	V:V:A136	V:V:D139	6.18	No	Yes	22	5	8
475	V:V:P137	V:V:Q138	4.74	No	No	0	4	4
476	V:V:E290	V:V:P137	9.43	No	No	0	5	4
477	V:V:D139	V:V:Q138	5.22	Yes	No	22	8	4
478	V:V:D139	V:V:K142	16.59	Yes	No	0	8	8
479	V:V:D139	V:V:R292	5.96	Yes	No	0	8	7
480	V:V:I324	V:V:V146	4.61	Yes	No	3	8	9
481	V:V:F148	V:V:K177	9.93	Yes	Yes	0	7	9
482	V:V:E149	V:V:K151	10.8	No	Yes	4	7	8
483	V:V:E149	V:V:R172	13.96	No	No	4	7	5
484	V:V:E149	V:V:L174	6.63	No	No	0	7	5
485	V:V:I175	V:V:V150	4.61	No	No	0	8	6
486	V:V:K151	V:V:R172	3.71	Yes	No	4	8	5
487	V:V:F153	V:V:I165	5.02	No	No	0	6	5
488	V:V:A154	V:V:S169	3.42	No	No	0	6	8
489	V:V:I157	V:V:S155	3.1	No	No	0	3	7
490	V:V:P160	V:V:T158	5.25	No	No	0	4	3
491	V:V:D159	V:V:P160	3.22	No	No	0	3	4
492	V:V:D163	V:V:E161	5.2	No	No	0	6	2
493	V:V:D163	V:V:K164	6.91	No	No	0	6	7
494	V:V:I165	V:V:P166	3.39	No	No	0	5	5
495	V:V:P166	V:V:S169	7.13	No	No	0	5	8
496	V:V:R176	V:V:V178	3.92	Yes	No	0	9	7
497	V:V:I300	V:V:R176	11.27	No	Yes	0	7	9
498	V:V:I312	V:V:Q179	6.86	Yes	No	0	5	9
499	V:V:H180	V:V:P361	7.63	No	No	0	4	7
500	V:V:A181	V:V:M357	3.22	No	No	0	9	8
501	V:V:I214	V:V:P182	3.39	No	No	0	5	9
502	V:V:K212	V:V:M185	10.08	Yes	No	0	8	4
503	V:V:G186	V:V:P187	4.06	No	No	0	5	4
504	V:V:E213	V:V:G186	6.55	Yes	No	0	7	5
505	V:V:P189	V:V:Q188	3.16	Yes	No	0	9	6
506	V:V:L210	V:V:P189	11.49	No	Yes	0	7	9
507	V:V:E213	V:V:P189	4.72	Yes	Yes	0	7	9
508	V:V:A191	V:V:V352	3.39	No	No	0	5	6
509	V:V:E192	V:V:S207	5.75	No	No	0	5	7
510	V:V:A193	V:V:W195	3.89	No	No	0	6	7
511	V:V:N205	V:V:S194	4.47	No	No	0	6	5
512	V:V:V348	V:V:W195	11.03	No	No	0	6	7
513	V:V:F197	V:V:S346	3.96	No	No	0	9	7
514	V:V:D232	V:V:S200	5.89	No	No	0	5	9
515	V:V:K202	V:V:T231	3	Yes	No	0	7	8
516	V:V:D232	V:V:K202	12.44	No	Yes	0	5	7
517	V:V:N230	V:V:P203	4.89	No	No	0	5	6
518	V:V:L204	V:V:N229	4.12	No	No	0	7	9
519	V:V:L206	V:V:V225	2.98	No	No	0	6	6
520	V:V:L206	V:V:L334	4.15	No	No	0	6	6
521	V:V:V208	V:V:V332	4.81	No	No	0	7	8
522	V:V:L210	V:V:V223	4.47	No	Yes	0	7	7
523	V:V:K212	V:V:S211	3.06	Yes	No	6	8	6
524	V:V:S211	V:V:Y215	5.09	No	Yes	6	6	6
525	V:V:P222	V:V:S211	5.34	Yes	No	6	4	6
526	V:V:K212	V:V:Y215	5.97	Yes	Yes	6	8	6
527	V:V:E219	V:V:K212	10.8	Yes	Yes	6	7	8
528	V:V:E213	V:V:I214	5.47	Yes	No	23	7	5
529	V:V:E213	V:V:R355	11.63	Yes	Yes	23	7	4
530	V:V:I214	V:V:R355	7.52	No	Yes	23	5	4
531	V:V:E219	V:V:Y215	5.61	Yes	Yes	6	7	6
532	V:V:I221	V:V:Y215	20.55	Yes	Yes	6	8	6
533	V:V:P222	V:V:Y215	5.56	Yes	Yes	6	4	6
534	V:V:F354	V:V:Y215	4.13	Yes	Yes	6	5	6
535	V:V:E219	V:V:F216	8.16	Yes	No	0	7	6
536	V:V:F216	V:V:P359	7.22	No	No	0	6	7
537	V:V:H217	V:V:N306	12.75	No	No	0	9	8
538	V:V:H217	V:V:L356	11.57	No	No	0	9	9
539	V:V:E219	V:V:P220	3.14	Yes	No	0	7	4
540	V:V:I221	V:V:P222	3.39	Yes	Yes	6	8	4
541	V:V:I221	V:V:P283	6.77	Yes	No	0	8	9
542	V:V:F354	V:V:I221	3.77	Yes	Yes	6	5	8
543	V:V:V223	V:V:V240	4.81	Yes	No	24	7	4
544	V:V:L281	V:V:V223	2.98	Yes	Yes	24	5	7
545	V:V:I330	V:V:V223	7.68	No	Yes	0	7	7
546	V:V:T224	V:V:T278	9.42	No	No	0	5	5
547	V:V:V225	V:V:V332	4.81	No	No	0	6	8
548	V:V:T226	V:V:T276	7.85	No	No	0	4	5
549	V:V:N230	V:V:T228	4.39	No	Yes	0	5	5
550	V:V:T228	V:V:T274	4.71	Yes	No	0	5	6
551	V:V:N229	V:V:T231	5.85	No	No	0	9	8
552	V:V:Q270	V:V:V234	4.3	Yes	No	0	4	4
553	V:V:S337	V:V:V234	3.23	No	No	0	6	4
554	V:V:V235	V:V:V269	4.81	No	Yes	0	7	6
555	V:V:E264	V:V:K237	6.75	No	No	0	6	6
556	V:V:K237	V:V:T335	6.01	No	No	0	6	4
557	V:V:I238	V:V:T265	3.04	No	No	0	6	5
558	V:V:I238	V:V:L334	5.71	No	No	0	6	6
559	V:V:K239	V:V:S262	3.06	No	No	0	5	1
560	V:V:E264	V:V:K239	10.8	No	No	0	6	5
561	V:V:L279	V:V:V240	2.98	No	No	0	4	4
562	V:V:L281	V:V:V240	7.45	Yes	No	24	5	4
563	V:V:E243	V:V:S241	5.75	Yes	No	0	5	5
564	V:V:S241	V:V:S262	3.26	No	No	0	5	1
565	V:V:V242	V:V:V260	3.21	Yes	No	0	7	8
566	V:V:A261	V:V:V242	3.39	No	Yes	0	6	7
567	V:V:L281	V:V:V242	4.47	Yes	Yes	0	5	7
568	V:V:I330	V:V:V242	4.61	No	Yes	0	7	7
569	V:V:E243	V:V:V257	7.13	Yes	No	0	5	5
570	V:V:E243	V:V:P259	3.14	Yes	No	0	5	3
571	V:V:E243	V:V:H329	12.31	Yes	No	0	5	5
572	V:V:E243	V:V:K331	14.85	Yes	No	0	5	7
573	V:V:A295	V:V:Q244	4.55	No	No	0	8	8
574	V:V:Q244	V:V:V326	4.3	No	No	6	8	9
575	V:V:Q244	V:V:Y328	15.78	No	Yes	6	8	9
576	V:V:H329	V:V:I245	6.63	No	No	0	5	4
577	V:V:N247	V:V:V249	4.43	Yes	No	13	6	8
578	V:V:N247	V:V:S253	5.96	Yes	No	13	6	6
579	V:V:N247	V:V:Y255	23.26	Yes	No	13	6	6
580	V:V:V248	V:V:Y256	3.79	No	No	0	8	7
581	V:V:S253	V:V:V249	3.23	No	No	13	6	8
582	V:V:L250	V:V:Y251	7.03	Yes	Yes	3	8	7
583	V:V:D254	V:V:S252	7.36	No	No	17	8	8
584	V:V:S253	V:V:Y255	5.09	No	No	13	6	6
585	V:V:D254	V:V:Y256	10.34	No	No	0	8	7
586	V:V:N288	V:V:V260	5.91	No	No	0	9	8
587	V:V:L307	V:V:V260	4.47	No	No	0	9	8
588	V:V:E267	V:V:T265	5.64	No	No	0	6	5
589	V:V:L275	V:V:V269	4.47	No	Yes	0	5	6
590	V:V:P271	V:V:Q270	6.32	No	Yes	0	5	4
591	V:V:K277	V:V:L279	5.64	No	No	0	7	4
592	V:V:L284	V:V:V282	4.47	No	No	0	3	4
593	V:V:L285	V:V:L296	5.54	Yes	No	21	8	8
594	V:V:L285	V:V:L307	5.54	Yes	No	0	8	9
595	V:V:N288	V:V:R291	9.64	No	No	0	9	7
596	V:V:I294	V:V:R291	7.52	No	No	0	7	7
597	V:V:D297	V:V:N306	8.08	No	No	25	9	8
598	V:V:D297	V:V:S309	8.83	No	No	0	9	9
599	V:V:D297	V:V:H358	3.78	No	No	25	9	8
600	V:V:H302	V:V:K299	9.17	No	No	0	7	5
601	V:V:K299	V:V:T305	3	No	No	0	5	8
602	V:V:E303	V:V:I300	5.47	No	No	0	6	7
603	V:V:H358	V:V:N306	12.75	No	No	25	8	8
604	V:V:A308	V:V:V326	5.09	No	No	0	9	9
605	V:V:S310	V:V:Y328	3.82	No	Yes	0	8	9
606	V:V:R355	V:V:S310	5.27	Yes	No	0	4	8
607	V:V:M357	V:V:S310	3.07	No	No	0	8	8
608	V:V:I312	V:V:R355	5.01	Yes	Yes	0	5	4
609	V:V:I312	V:V:M357	5.83	Yes	No	0	5	8
610	V:V:I317	V:V:K314	4.36	No	No	5	4	5
611	V:V:L325	V:V:V321	4.47	No	No	0	5	5
612	V:V:V326	V:V:Y328	5.05	No	Yes	6	9	9
613	V:V:F354	V:V:Y328	6.19	Yes	Yes	6	5	9
614	V:V:L356	V:V:Y328	5.86	No	Yes	0	9	9
615	V:V:E351	V:V:H329	19.69	No	No	0	7	5
616	V:V:F354	V:V:I330	6.28	Yes	No	0	5	7
617	V:V:A349	V:V:K331	3.21	No	No	0	3	7
618	V:V:E351	V:V:K331	4.05	No	No	0	7	7
619	V:V:E347	V:V:K333	10.8	No	No	0	7	7
620	V:V:G338	V:V:T344	3.64	No	No	0	6	4
621	V:V:F339	V:V:L340	7.31	No	No	0	2	4
622	V:V:G341	V:V:T344	3.64	No	No	0	4	4
623	V:V:P353	V:V:V352	3.53	No	No	0	8	6
624	V:V:H358	V:V:P359	4.58	No	No	0	8	7
625	V:V:P361	V:V:Q360	3.16	No	No	0	7	7
626	H:H:?1	H:H:?2	29.74	Yes	No	1	0	0
627	V:V:N229	V:V:V269	2.96	No	Yes	0	9	6
628	R:R:C316	R:R:H65	2.95	No	No	0	6	5
629	V:V:L109	V:V:T116	2.95	No	Yes	0	3	8
630	V:V:L279	V:V:T265	2.95	No	No	0	4	5
631	V:V:L296	V:V:T305	2.95	No	No	0	8	8
632	R:R:I255	R:R:I259	2.94	No	No	0	5	5
633	R:R:I259	R:R:I263	2.94	No	No	0	5	6
634	R:R:A166	R:R:H211	2.93	No	Yes	0	4	6
635	V:V:Q38	V:V:S37	2.89	No	No	0	2	4
636	V:V:D43	V:V:T102	2.89	No	No	0	7	7
637	V:V:Q90	V:V:V95	2.87	No	No	0	9	1
638	R:R:I300	R:R:L47	2.85	No	No	0	7	7
639	R:R:I48	R:R:L95	2.85	No	No	0	6	6
640	R:R:E247	R:R:V230	2.85	No	No	0	7	8
641	V:V:E40	V:V:V33	2.85	No	No	0	6	8
642	V:V:I324	V:V:L133	2.85	Yes	No	3	8	7
643	V:V:L101	V:V:M98	2.83	No	No	0	3	2
644	V:V:K177	V:V:L127	2.82	Yes	No	5	9	7
645	R:R:H65	R:R:V61	2.77	No	No	0	5	8
646	R:R:A299	R:R:F91	2.77	No	Yes	0	8	7
647	R:R:L95	R:R:L99	2.77	No	No	0	6	4
648	R:R:L119	R:R:L165	2.77	No	No	0	5	3
649	R:R:A153	R:R:F148	2.77	No	Yes	0	7	6
650	R:R:A246	V:V:F80	2.77	No	Yes	0	5	9
651	V:V:A65	V:V:R81	2.77	No	No	0	8	8
652	V:V:L325	V:V:N247	2.75	No	Yes	0	5	6
653	R:R:H65	R:R:T319	2.74	No	No	0	5	4
654	V:V:I73	V:V:Q70	2.74	Yes	No	0	8	8
655	V:V:E161	V:V:I157	2.73	No	No	0	2	3
656	R:R:E5	R:R:M1	2.71	No	No	0	6	7
657	R:R:C2	R:R:Y10	2.69	No	Yes	0	6	5
658	R:R:C140	R:R:Y136	2.69	No	No	0	7	8
659	R:R:C222	R:R:Y136	2.69	No	No	0	7	8
660	R:R:L194	R:R:Q279	2.66	No	No	0	1	1
661	V:V:E263	V:V:L281	2.65	No	Yes	0	3	5
662	V:V:F153	V:V:S155	2.64	No	No	0	6	7
663	R:R:F208	R:R:T213	2.59	No	No	0	6	4
664	R:R:V254	R:R:Y223	2.52	No	Yes	0	8	9
665	V:V:F339	V:V:M199	2.49	No	No	0	2	8
666	R:R:F146	V:V:K142	2.48	No	No	0	4	8
667	V:V:F339	V:V:K233	2.48	No	No	0	2	8
668	R:R:F52	R:R:L84	2.44	No	No	0	5	8
669	R:R:F276	R:R:L194	2.44	No	No	0	5	1
670	V:V:D83	V:V:F80	2.39	No	Yes	0	8	9
671	R:R:L226	R:R:Y223	2.34	No	Yes	0	8	9
672	R:R:F228	R:R:Q225	2.34	No	No	0	2	5
673	R:R:E249	R:R:R252	2.33	No	No	0	7	6
674	V:V:D125	V:V:Y126	2.3	No	Yes	5	5	5
675	R:R:N199	R:R:W175	2.26	No	Yes	0	1	4
676	R:R:G89	R:R:G90	2.11	No	No	0	5	7
677	R:R:G120	R:R:G121	2.11	No	No	0	8	7
678	V:V:C144	V:V:G145	1.96	No	No	0	8	8
679	R:R:A124	R:R:G121	1.95	No	No	0	9	7
680	V:V:A97	V:V:G96	1.95	No	No	0	3	2
681	V:V:P182	V:V:P183	1.95	No	No	0	9	3
682	R:R:A169	R:R:P170	1.87	No	No	0	4	7
683	R:R:G51	R:R:V87	1.84	No	No	0	8	6
684	R:R:G156	R:R:V130	1.84	No	No	0	5	7
685	V:V:G141	V:V:V140	1.84	No	No	0	7	4
686	R:R:G109	R:R:T108	1.82	No	No	0	5	1
687	R:R:G182	R:R:T289	1.82	No	No	0	2	4
688	V:V:A246	V:V:A295	1.79	No	No	0	7	8
689	V:V:P189	V:V:V352	1.77	Yes	No	0	9	6
690	V:V:P220	V:V:V280	1.77	No	No	0	4	4
691	V:V:P283	V:V:V282	1.77	No	No	0	9	4
692	V:V:P41	V:V:T122	1.75	No	No	0	5	4
693	V:V:P222	V:V:T278	1.75	Yes	No	0	4	5
694	R:R:A16	R:R:S14	1.71	No	No	0	4	6
695	R:R:G89	R:R:L88	1.71	No	No	0	5	4
696	V:V:G28	V:V:L27	1.71	No	Yes	0	7	8
697	V:V:G28	V:V:L104	1.71	No	Yes	0	7	5
698	V:V:G77	V:V:L78	1.71	No	No	0	9	6
699	V:V:G113	V:V:L112	1.71	No	No	0	9	7
700	V:V:G218	V:V:L284	1.71	No	No	0	8	3
701	V:V:G341	V:V:L340	1.71	No	No	0	4	4
702	V:V:A152	V:V:V23	1.7	No	No	0	5	5
703	V:V:A152	V:V:V171	1.7	No	Yes	0	5	7
704	R:R:I54	R:R:P303	1.69	No	No	0	7	9
705	R:R:A246	V:V:T79	1.68	No	No	0	5	6
706	V:V:A65	V:V:T63	1.68	No	Yes	0	8	7
707	V:V:A193	V:V:T350	1.68	No	No	0	6	5
708	V:V:K202	V:V:P203	1.67	Yes	No	0	7	6
709	V:V:K258	V:V:P259	1.67	No	No	0	5	3
710	R:R:G280	R:R:Q279	1.64	No	No	0	1	1
711	V:V:G141	V:V:Q70	1.64	No	No	0	7	8
712	V:V:E315	V:V:G316	1.64	No	No	0	3	4
713	V:V:S346	V:V:V348	1.62	No	No	0	7	6
714	V:V:A349	V:V:K333	1.61	No	No	0	3	7
715	V:V:S207	V:V:T226	1.6	No	No	0	7	4
716	V:V:S209	V:V:T224	1.6	No	No	0	7	5
717	V:V:V225	V:V:V227	1.6	No	No	0	6	6
718	V:V:V227	V:V:V269	1.6	No	Yes	0	6	6
719	V:V:V235	V:V:V336	1.6	No	No	0	7	5
720	R:R:T340	V:V:V12	1.59	No	No	0	7	5
721	V:V:T350	V:V:V208	1.59	No	No	0	5	7
722	V:V:P203	V:V:Q196	1.58	No	No	0	6	6
723	V:V:T224	V:V:T276	1.57	No	No	0	5	5
724	V:V:T226	V:V:T228	1.57	No	Yes	0	4	5
725	R:R:S343	V:V:I13	1.55	No	No	0	8	7
726	V:V:I165	V:V:S170	1.55	No	No	0	5	7
727	V:V:I245	V:V:S327	1.55	No	No	0	4	8
728	R:R:I54	R:R:V304	1.54	No	No	0	7	6
729	R:R:I205	R:R:V209	1.54	No	No	0	4	5
730	V:V:I312	V:V:V36	1.54	Yes	No	0	5	5
731	V:V:I313	V:V:V321	1.54	No	No	0	4	5
732	R:R:K141	R:R:S144	1.53	No	No	0	6	4
733	V:V:K233	V:V:S200	1.53	No	No	0	8	9
734	R:R:F103	R:R:G109	1.51	Yes	No	0	8	5
735	R:R:F105	R:R:G109	1.51	No	No	0	6	5
736	R:R:A333	R:R:E332	1.51	No	No	0	4	4
737	V:V:G293	V:V:R292	1.5	No	No	0	9	7
738	V:V:N205	V:V:T228	1.46	No	Yes	0	6	5
739	V:V:I294	V:V:K258	1.45	No	No	0	7	5
740	V:V:Q270	V:V:S273	1.44	Yes	No	0	4	6
741	V:V:I13	V:V:L104	1.43	No	Yes	19	7	5
742	V:V:I13	V:V:L108	1.43	No	No	19	7	9
743	V:V:D20	V:V:K168	1.38	Yes	No	0	8	8
744	V:V:D201	V:V:K202	1.38	No	Yes	0	6	7
745	R:R:K67	R:R:Q312	1.36	No	Yes	0	6	7
746	V:V:D147	V:V:L174	1.36	No	No	0	7	5
747	V:V:K268	V:V:Q270	1.36	No	Yes	0	5	4
748	R:R:E341	V:V:K15	1.35	No	No	0	7	8
749	R:R:E341	V:V:K111	1.35	No	No	0	7	9
750	V:V:E342	V:V:K236	1.35	No	No	0	4	8
751	R:R:E201	R:R:L194	1.33	No	No	0	3	1
752	R:R:D330	R:R:D331	1.33	No	No	0	4	4
753	R:R:E150	R:R:N151	1.31	No	No	0	1	5
754	R:R:F208	R:R:V209	1.31	No	No	0	6	5
755	V:V:D49	V:V:E51	1.3	No	No	0	8	3
756	R:R:?336	R:R:A335	1.29	Yes	No	0	6	6
757	R:R:Q238	R:R:Q244	1.28	No	No	0	3	3
758	R:R:V61	R:R:Y60	1.26	No	No	0	8	3
759	R:R:V204	R:R:Y191	1.26	No	Yes	0	5	5
760	R:R:S38	R:R:W35	1.24	No	Yes	0	4	2
761	R:R:K66	R:R:R69	1.24	No	No	0	5	7
762	R:R:M143	R:R:R147	1.24	No	No	0	5	5
763	R:R:F116	R:R:L112	1.22	No	No	0	4	5
764	V:V:L285	V:V:R289	1.21	Yes	No	0	8	5
765	V:V:D304	V:V:R289	1.19	No	No	0	8	5
766	V:V:D318	V:V:R319	1.19	No	No	0	4	5
767	R:R:N111	R:R:Y178	1.16	No	Yes	0	7	5
768	R:R:F56	R:R:Y60	1.03	No	No	0	4	3
769	R:R:R69	R:R:Y74	1.03	No	No	0	7	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F9	7.935	4	1	7
2	R:R:Y10	5.522	5	1	5
3	R:R:V11	4.15	4	1	5
4	R:R:P12	3.444	5	1	6
5	R:R:N15	11.0225	4	1	7
6	R:R:V20	7.448	5	1	5
7	R:R:S22	5.415	4	1	7
8	R:R:P23	7.554	5	1	5
9	R:R:F24	8.7175	4	1	5
10	R:R:Y29	5.9425	4	14	4
11	R:R:Y30	6.42667	6	1	4
12	R:R:L31	3.874	5	1	4
13	R:R:W35	7.74	4	0	2
14	R:R:Y43	9.04	4	8	4
15	R:R:M44	5.206	5	8	7
16	R:R:N55	6.5425	4	15	9
17	R:R:L68	6.0075	4	0	8
18	R:R:I75	6.215	4	2	7
19	R:R:N78	6.502	5	2	9
20	R:R:F91	5.03167	6	8	7
21	R:R:F103	6.312	5	1	8
22	R:R:T118	4.9425	4	0	5
23	R:R:E122	8.574	5	2	6
24	R:R:I123	5.12833	6	2	7
25	R:R:W126	8.36667	6	2	6
26	R:R:S127	4.2	4	2	7
27	R:R:V129	5.3325	4	2	7
28	R:R:L131	6.85	5	2	9
29	R:R:R135	7.165	4	2	9
30	R:R:P142	4.9975	4	3	7
31	R:R:F148	6.28	4	0	6
32	R:R:T160	3.5675	4	2	6
33	R:R:W175	7.334	5	0	4
34	R:R:Y178	7.748	5	0	5
35	R:R:I179	7.615	4	1	3
36	R:R:P180	5.236	5	1	1
37	R:R:E181	3.905	4	1	3
38	R:R:D190	9.9	5	1	4
39	R:R:Y191	4.60833	6	1	5
40	R:R:Y192	6.22714	7	1	4
41	R:R:T193	7.5575	4	1	3
42	R:R:K195	6.1025	4	1	4
43	R:R:N200	6.7125	4	1	5
44	R:R:F203	7.376	5	16	6
45	R:R:H211	8.90667	6	2	6
46	R:R:P215	7.2325	4	2	8
47	R:R:F220	4.6	4	10	4
48	R:R:Y223	4.34667	6	2	9
49	R:R:Y257	11.3325	4	2	8
50	R:R:Y268	4.8525	4	1	6
51	R:R:F283	7.72	4	12	2
52	R:R:P285	3.582	5	1	4
53	R:R:M288	5.0025	4	1	4
54	R:R:P291	5.3275	4	0	7
55	R:R:K296	5.3	4	8	7
56	R:R:Y301	5.2975	4	11	5
57	R:R:Y306	12.48	4	0	9
58	R:R:Q312	6.685	4	0	7
59	R:R:F313	5.92	6	2	8
60	R:R:?336	6.324	5	0	6
61	R:R:?338	7.49	5	9	8
62	V:V:R19	4.8325	4	18	5
63	V:V:D20	4.7625	4	0	8
64	V:V:S22	5.3525	4	0	5
65	V:V:Y26	9.01	4	0	8
66	V:V:L27	3.17	4	7	8
67	V:V:R30	7.33	4	9	9
68	V:V:Y32	5.83	5	7	7
69	V:V:V42	5.8775	4	7	7
70	V:V:V53	3.995	4	0	4
71	V:V:V58	4.87	4	0	7
72	V:V:Y59	8.862	5	4	4
73	V:V:T61	4.75	5	4	6
74	V:V:T63	3.5775	4	4	7
75	V:V:F66	4.96333	6	3	9
76	V:V:Y68	4.492	5	3	9
77	V:V:I73	5.76	4	0	8
78	V:V:M76	8.12	4	2	7
79	V:V:F80	3.57	4	0	9
80	V:V:R82	7.76	5	3	9
81	V:V:Y85	8.86	4	5	4
82	V:V:F86	8.055	4	4	4
83	V:V:R88	7.456	5	4	4
84	V:V:L104	4.2125	4	19	5
85	V:V:T116	5.6125	4	0	8
86	V:V:F119	6.24	4	7	9
87	V:V:L121	4.742	5	7	7
88	V:V:Y126	6.845	4	5	5
89	V:V:Q134	5.8325	4	21	8
90	V:V:D139	8.4875	4	22	8
91	V:V:F148	7.0525	4	0	7
92	V:V:K151	5.88	4	4	8
93	V:V:V171	3.9025	4	0	7
94	V:V:R176	8.6875	4	0	9
95	V:V:K177	8.8175	4	5	9
96	V:V:P189	5.285	4	0	9
97	V:V:K202	4.6225	4	0	7
98	V:V:K212	7.4775	4	6	8
99	V:V:E213	7.0925	4	23	7
100	V:V:Y215	7.81833	6	6	6
101	V:V:E219	6.9275	4	6	7
102	V:V:I221	8.62	4	6	8
103	V:V:P222	4.01	4	6	4
104	V:V:V223	4.985	4	24	7
105	V:V:T228	3.0325	4	0	5
106	V:V:V242	3.92	4	0	7
107	V:V:E243	8.636	5	0	5
108	V:V:N247	9.1	4	13	6
109	V:V:L250	5.614	5	3	8
110	V:V:Y251	4.3875	4	3	7
111	V:V:V269	3.46	4	0	6
112	V:V:Q270	3.355	4	0	4
113	V:V:L281	4.3875	4	24	5
114	V:V:L285	4.07	4	21	8
115	V:V:I312	4.81	4	0	5
116	V:V:I324	5.425	4	3	8
117	V:V:Y328	7.34	5	6	9
118	V:V:F354	5.0925	4	6	5
119	V:V:R355	7.3575	4	23	4
120	H:H:?1	15.862	5	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I179	R:R:P180	10.529	3.39	Yes	Yes	1	3	1
2	R:R:P267	R:R:P291	25.6429	3.9	No	Yes	0	9	7
3	R:R:F294	R:R:P267	13.5191	7.22	No	No	0	7	9
4	R:R:F293	R:R:F294	20.2767	11.79	No	No	0	4	7
5	R:R:F293	R:R:Y43	19.3849	13.41	No	Yes	8	4	4
6	R:R:D190	R:R:Y192	12.346	6.9	Yes	Yes	1	4	4
7	R:R:D190	R:R:N200	24.2497	10.77	Yes	Yes	1	4	5
8	R:R:N200	R:R:S176	25.1125	7.45	Yes	No	0	5	5
9	R:R:F203	R:R:S176	25.2884	10.57	Yes	No	0	6	5
10	R:R:F203	R:R:W175	24.9706	13.03	Yes	Yes	0	6	4
11	R:R:W175	R:R:Y206	26.0715	8.68	Yes	No	0	4	3
12	R:R:H211	R:R:Y206	26.2303	13.07	Yes	No	2	6	3
13	R:R:H211	R:R:W126	29.8869	4.23	Yes	Yes	2	6	6
14	R:R:T160	R:R:W126	87.3767	3.64	Yes	Yes	2	6	6
15	R:R:S127	R:R:T160	91.551	3.2	Yes	Yes	2	7	6
16	R:R:I75	R:R:S127	96.3652	4.64	Yes	Yes	2	7	7
17	R:R:E134	R:R:I75	91.9717	6.83	No	Yes	2	8	7
18	R:R:E134	R:R:F148	92.4515	8.16	No	Yes	0	8	6
19	R:R:F148	R:R:L72	93.2613	8.53	Yes	No	0	6	8
20	R:R:L72	R:R:V138	99.8364	2.98	No	No	0	8	8
21	R:R:E122	R:R:L125	26.9295	5.3	Yes	No	0	6	7
22	R:R:P215	R:R:W126	26.8655	12.16	Yes	Yes	2	8	6
23	R:R:P267	R:R:V266	13.1265	3.53	No	No	0	9	5
24	R:R:L262	R:R:V266	13.5151	2.98	No	No	0	5	5
25	R:R:F220	R:R:L262	13.8648	3.65	Yes	No	10	4	5
26	R:R:F220	R:R:F261	14.5672	3.22	Yes	No	10	4	9
27	R:R:F261	R:R:W265	16.2737	5.01	No	No	0	9	8
28	R:R:F294	R:R:I263	33.2244	5.02	No	No	0	7	6
29	R:R:I263	R:R:Y301	34.3979	4.84	No	Yes	0	6	5
30	R:R:C264	R:R:Y301	35.1408	4.03	No	Yes	11	9	5
31	R:R:C264	R:R:W265	36.4011	11.75	No	No	0	9	8
32	R:R:N145	R:R:V138	99.9237	5.91	No	No	0	5	8
33	R:R:N145	V:V:Y68	100	4.65	No	Yes	0	5	9
34	R:R:P142	V:V:Y68	46.9506	5.56	Yes	Yes	3	7	9
35	R:R:P142	V:V:F66	46.692	4.33	Yes	Yes	3	7	9
36	V:V:L250	V:V:Y68	46.4074	3.52	Yes	Yes	3	8	9
37	V:V:F66	V:V:L250	50.362	7.31	Yes	Yes	3	9	8
38	R:R:P291	R:R:V271	22.6026	7.07	Yes	No	0	7	5
39	R:R:I275	R:R:V271	10.8514	3.07	No	No	12	5	5
40	R:R:F283	R:R:Y274	16.2837	4.13	Yes	No	0	2	3
41	R:R:H278	R:R:Y274	14.4759	25.04	No	No	0	3	3
42	R:R:H278	R:R:T277	12.6677	5.48	No	No	0	3	4
43	R:R:F273	R:R:T277	10.8591	5.19	No	No	0	5	4
44	R:R:F287	R:R:V271	10.8514	6.55	No	No	12	5	5
45	V:V:F66	V:V:L84	93.7165	4.87	Yes	No	0	9	8
46	V:V:C64	V:V:L84	93.5909	6.35	No	No	0	9	8
47	V:V:C64	V:V:F148	93.4673	9.78	No	Yes	0	9	7
48	V:V:F148	V:V:K177	69.637	9.93	Yes	Yes	0	7	9
49	V:V:F148	V:V:S130	10.3162	5.28	Yes	No	0	7	9
50	V:V:R176	V:V:S130	10.0501	5.27	Yes	No	0	9	9
51	V:V:F123	V:V:F148	21.0684	3.22	No	Yes	0	5	7
52	V:V:F123	V:V:L62	28.3077	10.96	No	No	0	5	6
53	V:V:L121	V:V:L62	28.0587	6.92	Yes	No	0	7	6
54	V:V:L121	V:V:V42	17.8088	5.96	Yes	Yes	7	7	7
55	V:V:V42	V:V:Y32	10.8121	11.36	Yes	Yes	7	7	7
56	V:V:D34	V:V:K177	65.7873	17.97	No	Yes	5	9	9
57	V:V:D34	V:V:Q179	72.9274	9.14	No	No	0	9	9
58	V:V:I312	V:V:Q179	72.3277	6.86	Yes	No	0	5	9
59	V:V:I312	V:V:R355	40.7797	5.01	Yes	Yes	0	5	4
60	V:V:R355	V:V:S310	30.7947	5.27	Yes	No	0	4	8
61	V:V:S310	V:V:Y328	61.0098	3.82	No	Yes	0	8	9
62	V:V:F354	V:V:Y328	54.6598	6.19	Yes	Yes	6	5	9
63	V:V:F354	V:V:I330	20.1566	6.28	Yes	No	0	5	7
64	V:V:I330	V:V:V242	19.4492	4.61	No	Yes	0	7	7
65	V:V:V242	V:V:V260	18.646	3.21	Yes	No	0	7	8
66	V:V:I312	V:V:M357	31.1558	5.83	Yes	No	0	5	8
67	V:V:M357	V:V:S310	30.7057	3.07	No	No	0	8	8
68	V:V:N288	V:V:V260	11.7263	5.91	No	No	0	9	8
69	V:V:N288	V:V:R291	11.1969	9.64	No	No	0	9	7
70	V:V:I294	V:V:R291	10.6693	7.52	No	No	0	7	7
71	V:V:F354	V:V:Y215	18.7421	4.13	Yes	Yes	6	5	6
72	V:V:P222	V:V:Y215	14.0939	5.56	Yes	Yes	6	4	6
73	V:V:P222	V:V:T278	27.1234	1.75	Yes	No	0	4	5
74	V:V:T224	V:V:T278	26.0825	9.42	No	No	0	5	5
75	V:V:T224	V:V:T276	24.0065	1.57	No	No	0	5	5
76	V:V:T226	V:V:T276	22.9685	7.85	No	No	0	4	5
77	V:V:F354	V:V:I221	16.6414	3.77	Yes	Yes	6	5	8
78	V:V:I221	V:V:P222	14.0546	3.39	Yes	Yes	6	8	4
79	V:V:T226	V:V:T228	19.854	1.57	No	Yes	0	4	5
80	V:V:N230	V:V:T228	15.6991	4.39	No	Yes	0	5	5
81	V:V:N230	V:V:P203	14.6606	4.89	No	No	0	5	6
82	V:V:K202	V:V:P203	12.5842	1.67	Yes	No	0	7	6
83	V:V:I294	V:V:K258	10.1778	1.45	No	No	0	7	5
84	R:R:M44	R:R:Y43	11.1497	3.59	Yes	Yes	8	7	4
85	R:R:L125	R:R:W265	53.0103	11.39	No	No	0	7	8
86	R:R:D190	R:R:I179	10.0065	9.8	Yes	Yes	1	4	3
87	R:R:E122	R:R:W126	29.7748	7.63	Yes	Yes	2	6	6
88	R:R:L125	R:R:P215	26.5132	9.85	No	Yes	0	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 5W0P

PDB Summary
PDB	5W0P
Class	A
SubFamily	Sensory
Type	Opsins
SubType	Rhodopsin
Species	Homo sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	Arrestin1
PDB Resolution	3.01
Date	2017-08-09
D.O.I.	10.1016/j.cell.2017.07.002

Net Summary
I_min	2.98
Number of Linked Nodes	650
Number of Links	769
Number of Hubs	120
Number of Links mediated by Hubs	421
Number of Communities	25
Number of Nodes involved in Communities	176
Number of Links involved in Communities	238

Path Summary
Number Of Nodes in MetaPath	89
Number Of Links MetaPath	88
Number of Shortest Paths	788782
Length Of Smallest Path	3
Average Path Length	29.9054
Length of Longest Path	60
Minimum Path Strength	1.135
Average Path Strength	6.30275
Maximum Path Strength	27.12
Minimum Path Correlation	0.7
Average Path Correlation	0.97003
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.63158
Average % Of Corr. Nodes	41.7784
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.5008
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	TPO
PDB Residues	R:R:?336
Environment Details	Open EMBL-EBI Page
Code	TPO
Name	PHOSPHOTHREONINE
Synonyms	PHOSPHONOTHREONINE
Identifier	(2S,3R)-2-amino-3-phosphonooxy-butanoic acid
Formula	C4 H10 N O6 P
Molecular Weight	199.099
SMILES	C[C@H]([C@@H](C(=O)O)N)OP(=O)(O)O
PubChem	139055008
Formal Charge	0
Total Atoms	22
Total Chiral Atoms	2
Total Bonds	21
Total Aromatic Bonds	0


Code	SEP
PDB Residues	R:R:?338
Environment Details	Open EMBL-EBI Page
Code	SEP
Name	Dexfosfoserine
Synonyms	PHOSPHONOSERINE
Identifier	(2S)-2-amino-3-phosphonooxy-propanoic acid
Formula	C3 H8 N O6 P
Molecular Weight	185.072
SMILES	C([C@@H](C(=O)O)N)OP(=O)(O)O
PubChem	68841
Formal Charge	0
Total Atoms	19
Total Chiral Atoms	1
Total Bonds	18
Total Aromatic Bonds	0


Code	NAG
PDB Residues	H:H:?1 H:H:?2
Environment Details	Open EMBL-EBI Page
Code	NAG
Name	N-Acetylglucosamine
Synonyms	N-Acetyl-D-glucosamine
Identifier	N-[(2R,3R,4R,5S,6R)-6-(hydroxymethyl)-2,4,5-tris(oxidanyl)oxan-3-yl]ethanamide
Formula	C8 H15 N O6
Molecular Weight	221.208
SMILES	CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O
PubChem	24139
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	5
Total Bonds	30
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08100
Sequence	>5W0P_Chain_R M C G T E G P N F Y V P F S N A T G V V R S P F E Y P Q Y Y L A E P W Q F S M L A A Y M F L L I V L G F P I N F L T L Y V T V Q H K K L R T P L N Y I L L N L A V A D L F M V L G G F T S T L Y T S L H G Y F V F G P T G C N L Q G F F A T L G G E I A L W S L V V L A I E R Y V V V C K P M S N F R F G E N H A I M G V A F T W V M A L A C A A P P L A G W S R Y I P E G L Q C S C G I D Y Y T L K P E V N N E S F V I Y M F V V H F T I P M I I I F F C Y G Q L V F T V K E A A A Q Q Q E S A T T Q K A E K E V T R M V I I Y V I A F L I C W V P Y A S V A F Y I F T H Q G S C F G P I F M T I P A F F A K S A A I Y N P V I Y I M M N K Q F R N C M L T T I C C G D D E A S A ?V ? K T E T S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	V
Protein	Arrestin
UniProt	P20443
Sequence	>5W0P_Chain_V V I F K K V S R D K S V T I Y L G K R D Y V D H V S Q V E P V D G V V L V D P E L V K G K K V Y V T L T C A F R Y G Q E D I D V M G L T F R R D L Y F S R V Q V Y P P V G A M S V L T Q L Q E S L L K K L G D N T Y P F L L T F P D Y L P C S V M L Q P A P Q D V G K S C G V D F E V K A F A S D I T D P E E D K I P K K S S V R L L I R K V Q H A P P E M G P Q P S A E A S W Q F F M S D K P L N L S V S L S K E I Y F H G E P I P V T V T V T N N T D K V V K K I K V S V E Q I A N V V L Y S S D Y Y V K P V A S E E T Q E K V Q P N S T L T K T L V L V P L L A N N R E R R G I A L D G K I K H E D T N L A S S T I I K E G I D R T V M G I L V S Y H I K V K L T V S G F L G E L T S S E V A T E V P F R L M H P Q P E Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This network is also present in following consensuses:
	Id	Components
	arrestin1	5W0P-Rhodopsin-Arrestin1

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	1F88	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.8	2000-08-04	10.1126/science.289.5480.739
	1GZM	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.65	2003-11-20	10.1016/j.jmb.2004.08.090
	1HZX	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.8	2001-07-04	10.1021/bi0155091
	1L9H	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.6	2002-05-15	10.1073/pnas.082666399
	1U19	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.2	2004-10-12	10.1016/j.jmb.2004.07.044
	2G87	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-retinal	-	-	2.6	2006-09-02	10.1002/anie.200600595
	2HPY	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-retinal	-	-	2.8	2006-08-22	10.1073/pnas.0601765103
	2I35	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	3.8	2006-10-17	10.1073/pnas.0608022103
	2I36	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.1	2006-10-17	10.1073/pnas.0608022103
	2I37	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.15	2006-10-17	10.1073/pnas.0608022103
	2J4Y	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	3.4	2007-09-25	10.1016/j.jmb.2007.03.007
	2PED	A	Sensory	Opsins	Rhodopsin	Bos taurus	9-cis-Retinal	-	-	2.95	2007-10-30	10.1529/biophysj.107.108225
	2X72	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-retinal	-	Gt(CT)	3	2011-03-16	10.1038/nature09795
	2Z73	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	11-cis-Retinal	-	-	2.5	2008-05-13	10.1038/nature06925
	2ZIY	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	11-cis-Retinal	-	-	3.7	2008-05-06	10.1074/jbc.C800040200
	3AYM	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	All-trans-retinal	-	-	2.8	2011-08-17	10.1016/j.jmb.2011.08.044
	3AYN	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	9-cis-Retinal	-	-	2.7	2011-08-17	10.1016/j.jmb.2011.08.044
	3C9L	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.65	2008-08-05	10.1107/S0907444908017162
	3C9M	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	3.4	2008-08-05	10.1107/S0907444908017162
	3CAP	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	2.9	2008-06-24	10.1038/nature07063
	3DQB	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gt(CT)	3.2	2008-09-23	10.1038/nature07330
	3OAX	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.6	2011-01-19	10.1016/j.bpj.2010.08.003
	3PQR	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-retinal	-	Gt(CT)	2.85	2011-03-09	10.1038/nature09789
	3PXO	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-retinal	-	-	3	2011-03-09	10.1038/nature09789
	4A4M	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-retinal	-	Gt(CT)	3.3	2012-01-25	10.1073/pnas.1114089108
	4BEY	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gt(CT)	2.9	2013-05-08	10.1038/embor.2013.44
	4BEZ	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	3.3	2013-04-24	10.1038/embor.2013.44
	4J4Q	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl Beta-D-Glucopyranoside	-	Gt(CT)	2.65	2013-10-30	10.1002/anie.201302374
	4PXF	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl Beta-D-Glucopyranoside	-	Arrestin1_Finger_loop	2.75	2014-09-17	10.1038/ncomms5801
	4WW3	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	All-trans-retinal	-	-	2.8	2015-06-17	10.1371/journal.pone.0126970
	4X1H	A	Sensory	Opsins	Rhodopsin	Bos taurus	Nonyl Beta-D-Glucopyranoside	-	Gt(CT)	2.29	2015-11-04	10.1016/j.str.2015.09.015
	4ZWJ	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-	Arrestin1	3.3	2015-07-29	10.1038/nature14656
	5DGY	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-	Arrestin1	7.7	2016-03-23	10.1038/sdata.2016.21
	5DYS	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-retinal	-	-	2.3	2016-08-10	10.15252/embr.201642671
	5EN0	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-retinal	-	Gt(CT)	2.81	2016-08-10	10.15252/embr.201642671
	5TE3	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl Beta-D-Glucopyranoside	-	-	2.7	2017-03-15	10.1073/pnas.1617446114
	5TE5	A	Sensory	Opsins	Rhodopsin	Bos taurus	20-Methanoretinal	-	-	4.01	2017-03-15	10.1073/pnas.1617446114
	5W0P	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-	Arrestin1	3.01	2017-08-09	10.1016/j.cell.2017.07.002
	5WKT	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl Beta-D-Glucopyranoside	-	Gt(CT)	3.2	2017-12-13	10.1038/nprot.2017.135
	6CMO	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-	Gi1/&β;1/&γ;2	4.5	2018-06-20	10.1038/s41586-018-0215-y
	6FK6	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473033	-	2.36	2018-04-04	10.1073/pnas.1718084115
	6FK7	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473034	-	2.62	2018-04-04	10.1073/pnas.1718084115
	6FK8	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473035	-	2.87	2018-04-04	10.1073/pnas.1718084115
	6FK9	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473036	-	2.63	2018-04-04	10.1073/pnas.1718084115
	6FKA	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473037	-	2.7	2018-04-04	10.1073/pnas.1718084115
	6FKB	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473038	-	3.03	2018-04-04	10.1073/pnas.1718084115
	6FKC	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473039	-	2.46	2018-04-04	10.1073/pnas.1718084115
	6FKD	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 137349183	-	2.49	2018-04-04	10.1073/pnas.1718084115
	6FUF	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-retinal	-	Go/&β;1/&γ;2	3.12	2018-10-03	10.1126/sciadv.aat7052
	6I9K	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	9-cis-Retinal	-	-	2.15	2019-07-03	10.1073/pnas.1902192116
	6NWE	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl Beta-D-Glucopyranoside	-	Gt(CT)	2.71	2020-02-12	To be published
	6OFJ	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.5	2019-08-21	10.1074/jbc.RA119.010089
	6OY9	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-retinal	-	Gt/&β;1/&γ;1	3.9	2019-07-24	10.1016/j.molcel.2019.06.007
	6OYA	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-retinal	-	Gt/&β;1/&γ;1	3.3	2019-07-24	10.1016/j.molcel.2019.06.007
	6PEL	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Citronellol	Gt(CT)	3.19	2020-06-24	To be published
	6PGS	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Geraniol	Gt(CT)	2.9	2020-07-01	To be published
	6PH7	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Nerol	Gt(CT)	2.9	2020-07-01	To be published
	6QNO	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-retinal	-	Gi1/&β;1/&γ;1	4.38	2019-07-10	10.7554/eLife.46041
	7MT8	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-retinal	-	GRK1	5.8	2021-07-07	10.1038/s41586-021-03721-x
	7MT9	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-retinal	-	GRK1	7	2021-07-07	10.1038/s41586-021-03721-x
	7MTA	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-retinal	-	GRK1	4.1	2021-07-07	10.1038/s41586-021-03721-x
	7MTB	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-retinal	-	GRK1	4	2021-07-07	10.1038/s41586-021-03721-x
	7ZBC	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	1.8	2023-03-29	10.1038/s41586-023-05863-6
	7ZBE	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	1.8	2023-03-29	10.1038/s41586-023-05863-6
	8A6C	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-retinal	-	-	1.8	2023-03-29	10.1038/s41586-023-05863-6
	8A6D	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-retinal	-	-	1.8	2023-03-29	10.1038/s41586-023-05863-6
	8A6E	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-retinal	-	-	1.8	2023-03-29	10.1038/s41586-023-05863-6
	8FCZ	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	3.7	2023-08-30	10.1038/s41467-023-40911-9
	8FD0	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	3.71	2023-08-30	10.1038/s41467-023-40911-9
	8FD1	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.25	2023-08-30	10.1038/s41467-023-40911-9
	3CAP (Dimer)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	2.9	2008-06-24	10.1038/nature07063
	6OFJ (Dimer)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.5	2019-08-21	10.1074/jbc.RA119.010089
	8FCZ (Dimer)	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	3.7	2023-08-30	10.1038/s41467-023-40911-9
	8FD0 (Dimer)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	3.71	2023-08-30	10.1038/s41467-023-40911-9
	8FD1 (Dimer)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.25	2023-08-30	10.1038/s41467-023-40911-9

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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