psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D282	R:R:N2	13.46	No	No	0	2	6
2	R:R:G3	R:R:Y10	5.79	No	Yes	0	6	7
3	R:R:N15	R:R:T4	7.31	No	No	2	7	6
4	R:R:T4	R:R:V20	12.69	No	Yes	2	6	6
5	R:R:G6	R:R:P7	4.06	No	No	0	6	6
6	R:R:F9	R:R:G6	9.03	No	No	0	7	6
7	R:R:F24	R:R:N8	3.62	Yes	No	2	5	4
8	R:R:N8	R:R:P107	4.89	No	No	2	4	3
9	R:R:F9	R:R:S22	6.61	No	Yes	2	7	5
10	R:R:F9	R:R:P23	15.89	No	Yes	2	7	5
11	R:R:T193	R:R:Y10	6.24	Yes	Yes	0	5	7
12	R:R:P12	R:R:V11	3.53	No	Yes	0	8	8
13	R:R:V11	R:R:V20	4.81	Yes	Yes	2	8	6
14	R:R:P23	R:R:V11	3.53	Yes	Yes	2	5	8
15	R:R:Q28	R:R:V11	4.3	Yes	Yes	2	5	8
16	R:R:V11	R:R:Y30	5.05	Yes	Yes	2	8	4
17	R:R:P12	R:R:Q184	6.32	No	Yes	0	8	3
18	R:R:P12	R:R:P285	7.79	No	No	0	8	3
19	R:R:F13	R:R:Y30	8.25	No	Yes	2	4	4
20	R:R:F13	R:R:L31	3.65	No	Yes	2	4	4
21	R:R:K16	R:R:S14	9.18	No	No	0	7	4
22	R:R:G18	R:R:N15	5.09	No	No	0	3	7
23	R:R:N15	R:R:V20	10.35	No	Yes	2	7	6
24	R:R:T17	R:R:V19	6.35	No	No	0	6	3
25	R:R:V19	R:R:Y30	5.05	No	Yes	0	3	4
26	R:R:V20	R:R:Y30	12.62	Yes	Yes	2	6	4
27	R:R:P23	R:R:S22	3.56	Yes	Yes	2	5	5
28	R:R:F24	R:R:S22	3.96	Yes	Yes	2	5	5
29	R:R:E25	R:R:S22	5.75	No	Yes	0	7	5
30	R:R:P23	R:R:Q28	4.74	Yes	Yes	2	5	5
31	R:R:P180	R:R:P23	7.79	Yes	Yes	2	3	5
32	R:R:P23	R:R:Q184	7.9	Yes	Yes	2	5	3
33	R:R:F24	R:R:G106	6.02	Yes	No	2	5	8
34	R:R:F24	R:R:P107	21.67	Yes	No	2	5	3
35	R:R:C110	R:R:F24	5.59	Yes	Yes	2	9	5
36	R:R:F24	R:R:P180	7.22	Yes	Yes	2	5	3
37	R:R:P27	R:R:Y29	9.74	No	Yes	0	8	4
38	R:R:P27	R:R:Y102	6.95	No	No	0	8	4
39	R:R:Q28	R:R:Y30	12.4	Yes	Yes	2	5	4
40	R:R:L31	R:R:Q28	6.65	Yes	Yes	2	4	5
41	R:R:Q184	R:R:Q28	6.4	Yes	Yes	2	3	5
42	R:R:P34	R:R:Y29	11.13	No	Yes	0	3	4
43	R:R:F37	R:R:Y29	7.22	No	Yes	0	5	4
44	R:R:G101	R:R:Y29	4.35	No	Yes	0	4	4
45	R:R:L31	R:R:Y30	5.86	Yes	Yes	2	4	4
46	R:R:L31	R:R:P285	13.14	Yes	No	0	4	3
47	R:R:A32	R:R:Q36	4.55	No	Yes	0	3	2
48	R:R:A32	R:R:F37	4.16	No	No	0	3	5
49	R:R:E33	R:R:W35	8.72	No	No	4	3	3
50	R:R:E33	R:R:Q36	6.37	No	Yes	4	3	2
51	R:R:Q36	R:R:W35	17.52	Yes	No	4	2	3
52	R:R:I286	R:R:Q36	4.12	No	Yes	0	1	2
53	R:R:L40	R:R:T94	4.42	No	No	0	5	7
54	R:R:L40	R:R:S98	7.51	No	No	0	5	5
55	R:R:M44	R:R:Y43	3.59	No	Yes	0	7	4
56	R:R:L47	R:R:Y43	10.55	No	Yes	1	7	4
57	R:R:F293	R:R:Y43	10.32	No	Yes	0	5	4
58	R:R:T297	R:R:Y43	6.24	No	Yes	1	6	4
59	R:R:M44	R:R:T94	6.02	No	No	0	7	7
60	R:R:F45	R:R:M49	13.68	No	No	0	3	5
61	R:R:L46	R:R:L50	4.15	No	No	0	5	5
62	R:R:F91	R:R:L47	12.18	Yes	No	0	7	7
63	R:R:L47	R:R:T297	5.9	No	No	1	7	6
64	R:R:L50	R:R:V300	4.47	No	No	0	5	7
65	R:R:F52	R:R:P53	5.78	No	No	0	6	4
66	R:R:F52	R:R:F56	10.72	No	No	0	6	4
67	R:R:F52	R:R:F88	4.29	No	No	0	6	4
68	R:R:D83	R:R:N55	14.81	Yes	No	5	9	9
69	R:R:L84	R:R:N55	4.12	No	No	0	7	9
70	R:R:N55	R:R:P303	6.52	No	Yes	5	9	9
71	R:R:L57	R:R:M317	11.31	No	No	0	6	6
72	R:R:L321	R:R:L57	5.54	No	No	0	6	6
73	R:R:I307	R:R:T58	10.64	Yes	No	0	7	9
74	R:R:Q64	R:R:Y60	10.15	No	No	0	5	3
75	R:R:H65	R:R:V61	5.54	Yes	No	3	5	7
76	R:R:L68	R:R:V61	4.47	Yes	No	3	7	7
77	R:R:M317	R:R:V61	4.56	No	No	0	6	7
78	R:R:L77	R:R:T62	11.79	No	No	0	5	7
79	R:R:H65	R:R:L68	3.86	Yes	Yes	3	5	7
80	R:R:C316	R:R:H65	17.69	No	Yes	3	5	5
81	R:R:H65	R:R:T320	5.48	Yes	No	0	5	5
82	R:R:L68	R:R:Q312	3.99	Yes	No	0	7	6
83	R:R:F313	R:R:L68	9.74	Yes	Yes	0	8	7
84	R:R:C316	R:R:L68	7.94	No	Yes	3	5	7
85	R:R:N73	R:R:T70	5.85	No	No	0	8	7
86	R:R:F148	R:R:L72	7.31	Yes	No	0	7	8
87	R:R:F313	R:R:N73	9.67	Yes	No	0	8	8
88	R:R:E150	R:R:Y74	6.73	No	No	0	2	5
89	R:R:A153	R:R:Y74	5.34	No	No	0	7	5
90	R:R:I75	R:R:S127	6.19	No	No	0	7	8
91	R:R:I75	R:R:V130	6.14	No	No	0	7	7
92	R:R:I75	R:R:L131	4.28	No	No	0	7	9
93	R:R:I307	R:R:L76	4.28	Yes	No	0	7	8
94	R:R:I123	R:R:N78	4.25	Yes	Yes	0	7	9
95	R:R:N78	R:R:S127	5.96	Yes	No	6	9	8
96	R:R:N78	R:R:V157	7.39	Yes	No	0	9	7
97	R:R:N78	R:R:T160	7.31	Yes	No	6	9	7
98	R:R:D83	R:R:L79	4.07	Yes	No	0	9	9
99	R:R:L79	R:R:Y306	3.52	No	Yes	0	9	9
100	R:R:A299	R:R:D83	4.63	No	Yes	0	9	9
101	R:R:D83	R:R:P303	6.44	Yes	Yes	5	9	9
102	R:R:F116	R:R:F85	4.29	No	No	0	4	6
103	R:R:F91	R:R:M86	4.98	Yes	No	0	7	7
104	R:R:G121	R:R:M86	5.24	No	No	0	7	7
105	R:R:F88	R:R:V87	9.18	No	No	0	4	6
106	R:R:F91	R:R:V87	3.93	Yes	No	0	7	6
107	R:R:F91	R:R:K296	12.41	Yes	No	0	7	7
108	R:R:E113	R:R:T93	5.64	Yes	No	0	5	5
109	R:R:S186	R:R:T94	6.4	No	No	0	5	7
110	R:R:H100	R:R:Y96	15.24	No	No	0	4	4
111	R:R:F105	R:R:Y96	7.22	Yes	No	0	7	4
112	R:R:C185	R:R:T97	5.07	No	No	0	5	5
113	R:R:H100	R:R:V104	12.45	No	No	0	4	4
114	R:R:V104	R:R:Y102	11.36	No	No	0	4	4
115	R:R:C110	R:R:F103	4.19	Yes	Yes	2	9	8
116	R:R:E113	R:R:F103	8.16	Yes	Yes	0	5	8
117	R:R:C187	R:R:F103	8.38	No	Yes	2	9	8
118	R:R:F105	R:R:V104	7.87	Yes	No	0	7	4
119	R:R:G106	R:R:P107	4.06	No	No	2	8	3
120	R:R:C110	R:R:P180	3.77	Yes	Yes	2	9	3
121	R:R:C110	R:R:C187	7.28	Yes	No	2	9	9
122	R:R:L172	R:R:N111	4.12	Yes	No	0	5	7
123	R:R:E113	R:R:S186	4.31	Yes	No	0	5	5
124	R:R:G114	R:R:Y178	4.35	No	Yes	0	5	3
125	R:R:F115	R:R:F116	9.65	No	No	0	6	4
126	R:R:F115	R:R:L172	6.09	No	Yes	0	6	5
127	R:R:T118	R:R:Y178	9.99	No	Yes	0	4	3
128	R:R:I123	R:R:L119	7.14	Yes	No	0	7	5
129	R:R:E122	R:R:L125	3.98	Yes	No	1	6	7
130	R:R:C167	R:R:E122	10.64	No	Yes	1	5	6
131	R:R:E122	R:R:H211	11.08	Yes	Yes	1	6	6
132	L:L:?1	R:R:E122	4.41	Yes	Yes	0	0	6
133	R:R:I123	R:R:W161	11.74	Yes	No	0	7	9
134	R:R:F261	R:R:L125	3.65	Yes	No	1	9	7
135	R:R:L125	R:R:W265	18.22	No	Yes	1	7	8
136	R:R:V129	R:R:W126	7.36	No	Yes	1	7	5
137	R:R:M163	R:R:W126	20.94	No	Yes	0	4	5
138	R:R:H211	R:R:W126	7.41	Yes	Yes	1	6	5
139	R:R:P215	R:R:W126	9.46	No	Yes	1	9	5
140	R:R:S127	R:R:T160	4.8	No	No	6	8	7
141	R:R:L128	R:R:N302	6.87	No	No	1	8	9
142	R:R:L128	R:R:Y306	16.41	No	Yes	1	8	9
143	R:R:P215	R:R:V129	3.53	No	No	1	9	7
144	R:R:E134	R:R:V130	5.7	No	No	0	8	7
145	R:R:L131	R:R:R135	15.79	No	No	0	9	9
146	R:R:A132	R:R:Y223	9.34	No	Yes	0	9	9
147	R:R:E134	R:R:F148	13.99	No	Yes	0	8	7
148	R:R:R135	R:R:Y223	8.23	No	Yes	1	9	9
149	R:R:M257	R:R:R135	4.96	Yes	No	1	8	9
150	R:R:C140	R:R:Y136	6.72	No	Yes	0	7	7
151	R:R:P142	R:R:Y136	9.74	No	Yes	0	8	7
152	R:R:F221	R:R:Y136	6.19	No	Yes	7	4	7
153	R:R:C222	R:R:Y136	6.72	No	Yes	0	8	7
154	R:R:Q225	R:R:Y136	6.76	No	Yes	7	4	7
155	R:R:F146	R:R:V137	3.93	No	No	0	5	4
156	R:R:L226	R:R:V139	5.96	No	No	0	8	8
157	R:R:C140	R:R:T229	5.07	No	No	0	7	6
158	R:R:F146	R:R:M143	6.22	No	No	0	5	6
159	R:R:N145	R:R:S144	5.96	No	No	0	5	4
160	R:R:F146	R:R:H152	12.44	No	No	0	5	5
161	R:R:F148	R:R:H152	9.05	Yes	No	0	7	5
162	R:R:F159	R:R:M163	8.71	No	No	0	3	4
163	R:R:C167	R:R:M207	6.48	No	Yes	1	5	5
164	R:R:C167	R:R:H211	4.42	No	Yes	1	5	6
165	R:R:P170	R:R:P171	7.79	Yes	Yes	1	7	5
166	R:R:P170	R:R:W175	4.05	Yes	Yes	1	7	5
167	R:R:F203	R:R:P170	5.78	Yes	Yes	1	6	7
168	R:R:P171	R:R:S176	3.56	Yes	No	1	5	5
169	R:R:P171	R:R:Y178	12.52	Yes	Yes	0	5	3
170	R:R:F203	R:R:P171	7.22	Yes	Yes	1	6	5
171	R:R:L172	R:R:Y178	3.52	Yes	Yes	0	5	3
172	R:R:S202	R:R:W175	7.41	No	Yes	0	4	5
173	R:R:F203	R:R:W175	21.05	Yes	Yes	1	6	5
174	R:R:W175	R:R:Y206	10.61	Yes	No	1	5	4
175	R:R:N200	R:R:S176	5.96	Yes	No	1	4	5
176	R:R:F203	R:R:S176	13.21	Yes	No	1	6	5
177	R:R:I179	R:R:R177	8.77	No	Yes	1	1	5
178	R:R:D190	R:R:R177	11.91	Yes	Yes	1	4	5
179	R:R:R177	R:R:T193	3.88	Yes	Yes	1	5	5
180	R:R:H195	R:R:R177	25.95	Yes	Yes	1	4	5
181	R:R:I189	R:R:Y178	3.63	No	Yes	0	4	3
182	R:R:D190	R:R:I179	8.4	Yes	No	1	4	1
183	R:R:I179	R:R:Y192	6.04	No	Yes	1	1	5
184	R:R:P180	R:R:Q184	7.9	Yes	Yes	2	3	3
185	R:R:C187	R:R:P180	5.65	No	Yes	2	9	3
186	R:R:E181	R:R:Y268	5.61	No	Yes	0	4	6
187	R:R:I286	R:R:M183	4.37	No	No	0	1	2
188	R:R:M183	R:R:T289	6.02	No	No	0	2	4
189	R:R:F203	R:R:I189	6.28	Yes	No	0	6	4
190	R:R:D190	R:R:Y192	6.9	Yes	Yes	1	4	5
191	R:R:D190	R:R:T193	11.56	Yes	Yes	1	4	5
192	R:R:D190	R:R:N200	8.08	Yes	Yes	1	4	4
193	R:R:Y191	R:R:Y192	11.91	Yes	Yes	1	6	5
194	R:R:Y191	R:R:Y268	5.96	Yes	Yes	0	6	6
195	R:R:V271	R:R:Y191	3.79	No	Yes	0	5	6
196	R:R:M288	R:R:Y191	3.59	Yes	Yes	1	4	6
197	R:R:T193	R:R:Y192	3.75	Yes	Yes	1	5	5
198	R:R:M288	R:R:Y192	8.38	Yes	Yes	1	4	5
199	R:R:P194	R:R:T193	5.25	No	Yes	0	1	5
200	R:R:P194	R:R:Q279	7.9	No	No	0	1	1
201	R:R:E197	R:R:H195	17.23	No	Yes	0	3	4
202	R:R:H195	R:R:T198	10.95	Yes	No	1	4	1
203	R:R:H195	R:R:N200	5.1	Yes	Yes	1	4	4
204	R:R:N200	R:R:T198	5.85	Yes	No	1	4	1
205	R:R:E201	R:R:F276	11.66	No	No	0	3	4
206	R:R:F203	R:R:M207	6.22	Yes	Yes	1	6	5
207	R:R:F276	R:R:I205	6.28	No	No	0	4	5
208	R:R:V210	R:R:Y206	6.31	No	No	1	4	4
209	R:R:H211	R:R:Y206	9.8	Yes	No	1	6	4
210	R:R:H211	R:R:M207	6.57	Yes	Yes	1	6	5
211	L:L:?1	R:R:M207	11.28	Yes	Yes	0	0	5
212	R:R:F208	R:R:I213	7.54	No	No	0	5	4
213	R:R:H211	R:R:V210	6.92	Yes	No	1	6	4
214	R:R:F212	R:R:I213	3.77	Yes	No	0	8	4
215	R:R:A269	R:R:F212	8.32	No	Yes	0	7	8
216	R:R:I214	R:R:P215	6.77	No	No	0	5	9
217	R:R:F220	R:R:L216	4.87	No	Yes	0	5	7
218	R:R:F261	R:R:I219	7.54	Yes	No	0	9	8
219	R:R:F220	R:R:V258	5.24	No	No	0	5	8
220	R:R:F221	R:R:Q225	14.05	No	No	7	4	4
221	R:R:V254	R:R:Y223	8.83	No	Yes	0	8	9
222	R:R:M257	R:R:Y223	7.18	Yes	Yes	1	8	9
223	R:R:K231	R:R:V227	4.55	No	No	0	5	5
224	R:R:V227	R:R:V254	4.81	No	No	0	5	8
225	R:R:E247	R:R:K231	12.15	Yes	No	0	7	5
226	R:R:K231	R:R:T251	7.51	No	No	0	5	6
227	R:R:A234	R:R:Q244	4.55	No	No	0	5	4
228	R:R:E239	R:R:Q237	7.65	No	No	0	2	5
229	R:R:Q237	R:R:S240	4.33	No	No	8	5	4
230	R:R:Q237	R:R:T243	5.67	No	No	8	5	5
231	R:R:Q238	R:R:Q244	3.84	No	No	0	5	4
232	R:R:S240	R:R:T243	6.4	No	No	8	4	5
233	R:R:E247	R:R:K248	8.1	Yes	No	0	7	4
234	R:R:E249	R:R:R252	9.3	No	No	0	7	7
235	R:R:E249	R:R:M253	4.06	No	No	0	7	8
236	R:R:I256	R:R:R252	3.76	No	No	0	5	7
237	R:R:M253	R:R:M257	4.33	No	Yes	0	8	8
238	R:R:I256	R:R:I305	4.42	No	No	0	5	8
239	R:R:M257	R:R:Y306	14.37	Yes	Yes	1	8	9
240	R:R:F261	R:R:W265	9.02	Yes	Yes	1	9	8
241	R:R:C264	R:R:W265	13.06	No	Yes	1	8	8
242	R:R:C264	R:R:S298	5.16	No	No	1	8	9
243	R:R:C264	R:R:Y301	5.38	No	No	1	8	5
244	R:R:A295	R:R:W265	3.89	No	Yes	0	8	8
245	L:L:?1	R:R:W265	5.3	Yes	Yes	0	0	8
246	R:R:F294	R:R:P267	8.67	No	No	0	7	9
247	R:R:P291	R:R:Y268	12.52	No	Yes	0	6	6
248	L:L:?1	R:R:Y268	15.59	Yes	Yes	0	0	6
249	R:R:F287	R:R:V271	3.93	No	No	0	4	5
250	R:R:F273	R:R:T277	6.49	No	No	0	6	5
251	R:R:H278	R:R:Y274	27.22	No	No	0	3	4
252	R:R:F283	R:R:Y274	4.13	Yes	No	0	4	4
253	R:R:F283	R:R:I275	5.02	Yes	No	0	4	4
254	R:R:H278	R:R:T277	5.48	No	No	0	3	5
255	R:R:F283	R:R:F287	25.72	Yes	No	1	4	4
256	R:R:F283	R:R:M288	3.73	Yes	Yes	1	4	4
257	R:R:G284	R:R:P285	4.06	No	No	0	4	3
258	R:R:F287	R:R:M288	3.73	No	Yes	1	4	4
259	R:R:F293	R:R:F294	15	No	No	0	5	7
260	L:L:?1	R:R:K296	9.38	Yes	No	0	0	7
261	R:R:T297	R:R:Y301	4.99	No	No	1	6	5
262	R:R:S298	R:R:Y301	6.36	No	No	1	9	5
263	R:R:N302	R:R:S298	7.45	No	No	1	9	9
264	R:R:N302	R:R:Y306	4.65	No	Yes	1	9	9
265	R:R:I305	R:R:Y306	7.25	No	Yes	0	8	9
266	R:R:F313	R:R:I307	3.77	Yes	Yes	0	8	7
267	R:R:F313	R:R:N310	10.87	Yes	No	0	8	8
268	R:R:E232	R:R:F228	3.5	No	No	0	4	3
269	R:R:C185	R:R:S98	3.44	No	No	0	5	5
270	R:R:A41	R:R:S98	3.42	No	No	0	5	5
271	R:R:G109	R:R:L112	3.42	Yes	No	0	5	4
272	R:R:I54	R:R:P303	3.39	No	Yes	0	8	9
273	R:R:I290	R:R:P291	3.39	No	No	0	5	6
274	R:R:I307	R:R:P303	3.39	Yes	Yes	0	7	9
275	R:R:A80	R:R:T58	3.36	No	No	0	9	9
276	R:R:A168	R:R:T118	3.36	No	No	0	7	4
277	R:R:L266	R:R:P267	3.28	No	No	0	6	9
278	R:R:E113	R:R:G90	3.27	Yes	No	0	5	6
279	R:R:E181	R:R:G188	3.27	No	No	0	4	5
280	R:R:A82	R:R:I123	3.25	No	Yes	0	8	7
281	L:L:?1	R:R:F212	3.24	Yes	Yes	0	0	8
282	R:R:A42	R:R:M39	3.22	No	No	0	5	4
283	R:R:F103	R:R:F105	3.22	Yes	Yes	2	8	7
284	R:R:V129	R:R:V218	3.21	No	No	0	7	6
285	R:R:V230	R:R:V250	3.21	No	No	0	8	8
286	R:R:A41	R:R:L99	3.15	No	No	0	5	4
287	R:R:I133	R:R:V218	3.07	No	No	0	6	6
288	R:R:I255	R:R:T251	3.04	No	No	0	5	6
289	R:R:A234	R:R:E247	3.02	No	Yes	0	5	7
290	R:R:L59	R:R:V81	2.98	No	No	0	7	6
291	R:R:L68	R:R:T62	2.95	Yes	No	0	7	7
292	R:R:I213	R:R:I217	2.94	No	No	0	4	4
293	R:R:I255	R:R:I259	2.94	No	No	0	5	5
294	R:R:I259	R:R:I263	2.94	No	No	0	5	5
295	R:R:I48	R:R:M49	2.92	No	No	0	6	5
296	R:R:I54	R:R:M308	2.92	No	No	0	8	6
297	R:R:F148	R:R:P71	2.89	Yes	No	0	7	6
298	R:R:Q64	R:R:V63	2.87	No	No	0	5	2
299	R:R:I48	R:R:L95	2.85	No	No	0	6	6
300	R:R:E247	R:R:V230	2.85	Yes	No	0	7	8
301	R:R:A26	R:R:R21	2.77	No	No	0	2	4
302	R:R:L95	R:R:L99	2.77	No	No	0	6	4
303	R:R:L119	R:R:L165	2.77	No	No	0	5	3
304	R:R:A153	R:R:F148	2.77	No	Yes	0	7	7
305	R:R:L216	R:R:L262	2.77	Yes	No	0	7	6
306	R:R:H65	R:R:T319	2.74	Yes	No	0	5	4
307	R:R:K67	R:R:Q312	2.71	No	No	0	5	6
308	R:R:A272	R:R:Y191	2.67	No	Yes	0	5	6
309	R:R:A292	R:R:Y268	2.67	No	Yes	0	5	6
310	R:R:F85	R:R:V81	2.62	No	No	0	6	6
311	R:R:F148	R:R:V138	2.62	Yes	No	0	7	8
312	R:R:E196	R:R:E197	2.54	No	No	0	1	3
313	R:R:V204	R:R:Y191	2.52	No	Yes	0	4	6
314	R:R:T320	R:R:Y60	2.5	No	No	0	5	3
315	R:R:K66	R:R:R69	2.48	No	No	0	6	6
316	R:R:K311	R:R:R314	2.48	No	No	0	4	8
317	R:R:F212	R:R:L216	2.44	Yes	Yes	0	8	7
318	R:R:F261	R:R:L216	2.44	Yes	Yes	0	9	7
319	R:R:I154	R:R:Y74	2.42	No	No	0	3	5
320	R:R:L46	R:R:Y43	2.34	No	Yes	0	5	4
321	R:R:F228	R:R:Q225	2.34	No	No	0	3	4
322	R:R:M39	R:R:W35	2.33	No	No	0	4	3
323	R:R:N199	R:R:W175	2.26	No	Yes	0	3	5
324	R:R:E5	R:R:Y10	2.24	No	Yes	0	6	7
325	R:R:G89	R:R:G90	2.11	No	No	0	4	6
326	R:R:G120	R:R:G121	2.11	No	No	0	8	7
327	L:L:?1	R:R:A117	2.1	Yes	No	0	0	5
328	R:R:G51	R:R:P53	2.03	No	No	0	8	4
329	R:R:C323	R:R:G324	1.96	No	No	0	9	3
330	R:R:A124	R:R:G121	1.95	No	No	0	9	7
331	R:R:A269	R:R:G270	1.95	No	No	0	7	5
332	R:R:A26	R:R:P27	1.87	No	No	0	2	8
333	R:R:A169	R:R:P170	1.87	No	Yes	0	3	7
334	R:R:G280	R:R:S281	1.86	No	No	0	1	4
335	R:R:G156	R:R:V130	1.84	No	No	0	6	7
336	R:R:G109	R:R:T108	1.82	Yes	No	0	5	1
337	R:R:G174	R:R:T198	1.82	No	No	0	5	1
338	R:R:G182	R:R:T289	1.82	No	No	0	3	4
339	R:R:A132	R:R:C222	1.81	No	No	0	9	8
340	R:R:G156	R:R:M155	1.75	No	No	0	6	2
341	R:R:G324	R:R:K325	1.74	No	No	0	3	3
342	R:R:C322	R:R:V318	1.71	No	No	0	4	3
343	R:R:A234	R:R:T243	1.68	No	No	0	5	5
344	R:R:K141	R:R:P142	1.67	No	No	0	6	8
345	R:R:A164	R:R:I123	1.62	No	Yes	0	8	7
346	R:R:A260	R:R:I305	1.62	No	No	0	7	8
347	R:R:A241	R:R:K245	1.61	No	No	0	3	4
348	R:R:V138	R:R:V139	1.6	No	No	0	8	8
349	R:R:V209	R:R:V210	1.6	No	No	0	5	4
350	R:R:S240	R:R:T242	1.6	No	No	0	4	4
351	R:R:G149	R:R:H152	1.59	No	No	0	6	5
352	R:R:T92	R:R:T93	1.57	No	No	0	8	5
353	R:R:C322	R:R:N326	1.57	No	No	0	4	3
354	R:R:I205	R:R:V209	1.54	No	No	0	5	5
355	R:R:M39	R:R:S38	1.53	No	No	0	4	2
356	R:R:M308	R:R:V304	1.52	No	No	0	6	7
357	R:R:F103	R:R:G109	1.51	Yes	Yes	2	8	5
358	R:R:F105	R:R:G109	1.51	Yes	Yes	2	7	5
359	R:R:K16	R:R:T17	1.5	No	No	0	7	6
360	R:R:K325	R:R:T319	1.5	No	No	0	3	4
361	R:R:L172	R:R:V173	1.49	Yes	No	0	5	4
362	R:R:A166	R:R:H211	1.46	No	Yes	0	4	6
363	R:R:K311	R:R:N315	1.4	No	No	0	4	5
364	R:R:H278	R:R:S281	1.39	No	No	0	3	4
365	R:R:R314	R:R:V318	1.31	No	No	0	8	3
366	R:R:R69	R:R:T62	1.29	No	No	0	6	7
367	R:R:M309	R:R:R252	1.24	No	No	0	7	7
368	R:R:N2	R:R:Y10	1.16	No	Yes	0	6	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y10	3.8575	4	0	7
2	R:R:V11	4.244	5	2	8
3	R:R:V20	10.1175	4	2	6
4	R:R:S22	4.97	4	2	5
5	R:R:P23	7.235	6	2	5
6	R:R:F24	8.01333	6	2	5
7	R:R:Q28	6.898	5	2	5
8	R:R:Y29	8.11	4	0	4
9	R:R:Y30	8.205	6	2	4
10	R:R:L31	7.325	4	2	4
11	R:R:Q36	8.14	4	4	2
12	R:R:Y43	6.608	5	1	4
13	R:R:H65	7.062	5	3	5
14	R:R:L68	5.49167	6	3	7
15	R:R:N78	6.2275	4	6	9
16	R:R:D83	7.4875	4	5	9
17	R:R:F91	8.375	4	0	7
18	R:R:F103	5.092	5	2	8
19	R:R:F105	4.955	4	2	7
20	R:R:G109	2.065	4	2	5
21	R:R:C110	5.2075	4	2	9
22	R:R:E113	5.345	4	0	5
23	R:R:E122	7.5275	4	1	6
24	R:R:I123	5.6	5	0	7
25	R:R:W126	11.2925	4	1	5
26	R:R:Y136	7.226	5	7	7
27	R:R:F148	6.43833	6	0	7
28	R:R:P170	4.8725	4	1	7
29	R:R:P171	7.7725	4	1	5
30	R:R:L172	3.805	4	0	5
31	R:R:W175	9.076	5	1	5
32	R:R:R177	12.6275	4	1	5
33	R:R:Y178	6.802	5	0	3
34	R:R:P180	6.466	5	2	3
35	R:R:Q184	7.13	4	2	3
36	R:R:D190	9.37	5	1	4
37	R:R:Y191	5.07333	6	1	6
38	R:R:Y192	7.396	5	1	5
39	R:R:T193	6.136	5	1	5
40	R:R:H195	14.8075	4	1	4
41	R:R:N200	6.2475	4	1	4
42	R:R:F203	9.96	6	1	6
43	R:R:M207	7.6375	4	1	5
44	R:R:H211	6.80857	7	1	6
45	R:R:F212	4.4425	4	0	8
46	R:R:L216	3.13	4	0	7
47	R:R:Y223	8.395	4	1	9
48	R:R:E247	6.53	4	0	7
49	R:R:M257	7.71	4	1	8
50	R:R:F261	5.6625	4	1	9
51	R:R:W265	9.898	5	1	8
52	R:R:Y268	8.47	5	0	6
53	R:R:F283	9.65	4	1	4
54	R:R:M288	4.8575	4	1	4
55	R:R:P303	4.935	4	5	9
56	R:R:Y306	9.24	5	1	9
57	R:R:I307	5.52	4	0	7
58	R:R:F313	8.5125	4	0	8
59	L:L:?1	7.32857	7	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Y191	R:R:Y192	13.1349	11.91	Yes	Yes	1	6	5
2	R:R:Y191	R:R:Y268	27.0512	5.96	Yes	Yes	0	6	6
3	L:L:?1	R:R:Y268	32.3214	15.59	Yes	Yes	0	0	6
4	L:L:?1	R:R:K296	53.6273	9.38	Yes	No	0	0	7
5	R:R:F91	R:R:K296	53.38	12.41	Yes	No	0	7	7
6	R:R:F91	R:R:L47	57.3376	12.18	Yes	No	0	7	7
7	R:R:L47	R:R:Y43	53.4165	10.55	No	Yes	1	7	4
8	R:R:M44	R:R:Y43	100	3.59	No	Yes	0	7	4
9	R:R:M44	R:R:T94	99.6177	6.02	No	No	0	7	7
10	R:R:S186	R:R:T94	95.0417	6.4	No	No	0	5	7
11	R:R:E113	R:R:S186	94.5892	4.31	Yes	No	0	5	5
12	R:R:E113	R:R:F103	92.304	8.16	Yes	Yes	0	5	8
13	R:R:C110	R:R:F103	42.2689	4.19	Yes	Yes	2	9	8
14	R:R:C110	R:R:P180	33.6004	3.77	Yes	Yes	2	9	3
15	R:R:P180	R:R:P23	42.8114	7.79	Yes	Yes	2	3	5
16	R:R:P23	R:R:V11	20.0045	3.53	Yes	Yes	2	5	8
17	R:R:C187	R:R:F103	34.3733	8.38	No	Yes	2	9	8
18	R:R:C187	R:R:P180	33.6228	5.65	No	Yes	2	9	3
19	R:R:P180	R:R:Q184	23.1161	7.9	Yes	Yes	2	3	3
20	R:R:P23	R:R:Q28	16.3476	4.74	Yes	Yes	2	5	5
21	R:R:Q184	R:R:Q28	16.1143	6.4	Yes	Yes	2	3	5
22	R:R:V11	R:R:Y30	10.9115	5.05	Yes	Yes	2	8	4
23	R:R:Q28	R:R:Y30	21.6404	12.4	Yes	Yes	2	5	4
24	R:R:V19	R:R:Y30	21.7865	5.05	No	Yes	0	3	4
25	R:R:T17	R:R:V19	16.3476	6.35	No	No	0	6	3
26	R:R:K16	R:R:T17	10.9031	1.5	No	No	0	7	6
27	R:R:F103	R:R:F105	25.227	3.22	Yes	Yes	2	8	7
28	R:R:F105	R:R:V104	22.3656	7.87	Yes	No	0	7	4
29	R:R:V104	R:R:Y102	20.398	11.36	No	No	0	4	4
30	R:R:P27	R:R:Y102	19.3749	6.95	No	No	0	8	4
31	R:R:P27	R:R:Y29	16.2717	9.74	No	Yes	0	8	4
32	R:R:F37	R:R:Y29	13.118	7.22	No	Yes	0	5	4
33	R:R:A32	R:R:F37	12.0555	4.16	No	No	0	3	5
34	R:R:A32	R:R:Q36	10.9874	4.55	No	Yes	0	3	2
35	R:R:L40	R:R:T94	10.9874	4.42	No	No	0	5	7
36	L:L:?1	R:R:W265	40.0512	5.3	Yes	Yes	0	0	8
37	R:R:C264	R:R:W265	50.9318	13.06	No	Yes	1	8	8
38	R:R:T297	R:R:Y301	53.6667	4.99	No	No	1	6	5
39	R:R:C264	R:R:S298	46.4092	5.16	No	No	1	8	9
40	R:R:N302	R:R:S298	95.0052	7.45	No	No	1	9	9
41	R:R:N302	R:R:Y306	93.611	4.65	No	Yes	1	9	9
42	R:R:L79	R:R:Y306	40.0905	3.52	No	Yes	0	9	9
43	R:R:D83	R:R:L79	39.1348	4.07	Yes	No	0	9	9
44	R:R:D83	R:R:P303	35.0704	6.44	Yes	Yes	5	9	9
45	R:R:I307	R:R:P303	31.2871	3.39	Yes	Yes	0	7	9
46	R:R:F313	R:R:I307	27.2283	3.77	Yes	Yes	0	8	7
47	R:R:F313	R:R:L68	23.1357	9.74	Yes	Yes	0	8	7
48	R:R:H65	R:R:L68	10.0177	3.86	Yes	Yes	3	5	7
49	R:R:M257	R:R:Y306	64.092	14.37	Yes	Yes	1	8	9
50	R:R:M257	R:R:R135	31.5513	4.96	Yes	No	1	8	9
51	R:R:L131	R:R:R135	33.4036	15.79	No	No	0	9	9
52	R:R:I75	R:R:L131	32.4086	4.28	No	No	0	7	9
53	R:R:I75	R:R:V130	21.0923	6.14	No	No	0	7	7
54	R:R:E134	R:R:V130	17.888	5.7	No	No	0	8	7
55	R:R:E134	R:R:F148	16.8086	13.99	No	Yes	0	8	7
56	R:R:I75	R:R:S127	11.3809	6.19	No	No	0	7	8
57	R:R:P171	R:R:Y178	12.6739	12.52	Yes	Yes	0	5	3
58	R:R:L172	R:R:Y178	15.9626	3.52	Yes	Yes	0	5	3
59	L:L:?1	R:R:E122	16.3364	4.41	Yes	Yes	0	0	6
60	L:L:?1	R:R:M207	48.8096	11.28	Yes	Yes	0	0	5
61	R:R:F203	R:R:M207	35.5201	6.22	Yes	Yes	1	6	5
62	R:R:H211	R:R:M207	16.432	6.57	Yes	Yes	1	6	5
63	R:R:E122	R:R:H211	20.1029	11.08	Yes	Yes	1	6	6
64	R:R:H211	R:R:W126	18.4586	7.41	Yes	Yes	1	6	5
65	R:R:A132	R:R:Y223	12.4884	9.34	No	Yes	0	9	9
66	R:R:M257	R:R:Y223	30.5591	7.18	Yes	Yes	1	8	9
67	R:R:C222	R:R:Y136	10.2679	6.72	No	Yes	0	8	7
68	R:R:A132	R:R:C222	11.3809	1.81	No	No	0	9	8
69	R:R:F203	R:R:I189	12.1848	6.28	Yes	No	0	6	4
70	R:R:H211	R:R:V210	11.4653	6.92	Yes	No	1	6	4
71	R:R:V254	R:R:Y223	21.0895	8.83	No	Yes	0	8	9
72	R:R:V227	R:R:V254	20.0214	4.81	No	No	0	5	8
73	R:R:K231	R:R:V227	18.9533	4.55	No	No	0	5	5
74	R:R:E247	R:R:K231	13.5284	12.15	Yes	No	0	7	5
75	R:R:T297	R:R:Y43	49.4364	6.24	No	Yes	1	6	4
76	R:R:S298	R:R:Y301	49.1272	6.36	No	No	1	9	5
77	R:R:F203	R:R:P171	12.064	7.22	Yes	Yes	1	6	5
78	R:R:I189	R:R:Y178	11.1673	3.63	No	Yes	0	4	3

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F91	R:R:K296	12.41	0	Yes	No	7	7	2	1
R:R:E122	R:R:L125	3.98	1	Yes	No	6	7	1	2
R:R:C167	R:R:E122	10.64	1	No	Yes	5	6	2	1
R:R:E122	R:R:H211	11.08	1	Yes	Yes	6	6	1	2
L:L:?1	R:R:E122	4.41	0	Yes	Yes	0	6	0	1
R:R:F261	R:R:L125	3.65	1	Yes	No	9	7	2	2
R:R:L125	R:R:W265	18.22	1	No	Yes	7	8	2	1
R:R:C167	R:R:M207	6.48	1	No	Yes	5	5	2	1
R:R:C167	R:R:H211	4.42	1	No	Yes	5	6	2	2
R:R:E181	R:R:Y268	5.61	0	No	Yes	4	6	2	1
R:R:Y191	R:R:Y268	5.96	1	Yes	Yes	6	6	2	1
R:R:F203	R:R:M207	6.22	1	Yes	Yes	6	5	2	1
R:R:H211	R:R:M207	6.57	1	Yes	Yes	6	5	2	1
L:L:?1	R:R:M207	11.28	0	Yes	Yes	0	5	0	1
R:R:F212	R:R:I213	3.77	0	Yes	No	8	4	1	2
R:R:A269	R:R:F212	8.32	0	No	Yes	7	8	2	1
R:R:F261	R:R:W265	9.02	1	Yes	Yes	9	8	2	1
R:R:C264	R:R:W265	13.06	1	No	Yes	8	8	2	1
R:R:A295	R:R:W265	3.89	0	No	Yes	8	8	2	1
L:L:?1	R:R:W265	5.3	0	Yes	Yes	0	8	0	1
R:R:P291	R:R:Y268	12.52	0	No	Yes	6	6	2	1
L:L:?1	R:R:Y268	15.59	0	Yes	Yes	0	6	0	1
L:L:?1	R:R:K296	9.38	0	Yes	No	0	7	0	1
L:L:?1	R:R:F212	3.24	0	Yes	Yes	0	8	0	1
R:R:A292	R:R:Y268	2.67	0	No	Yes	5	6	2	1
R:R:F212	R:R:L216	2.44	0	Yes	Yes	8	7	1	2
R:R:F261	R:R:L216	2.44	1	Yes	Yes	9	7	2	2
L:L:?1	R:R:A117	2.1	0	Yes	No	0	5	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	3PQR_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.52
Number of Linked Nodes	317
Number of Links	368
Number of Hubs	59
Number of Links mediated by Hubs	208
Number of Communities	8
Number of Nodes involved in Communities	82
Number of Links involved in Communities	118

Path Summary
Number Of Nodes in MetaPath	79
Number Of Links MetaPath	78
Number of Shortest Paths	77077
Length Of Smallest Path	3
Average Path Length	16.0699
Length of Longest Path	34
Minimum Path Strength	1.51
Average Path Strength	6.9997
Maximum Path Strength	21.59
Minimum Path Correlation	0.7
Average Path Correlation	0.933879
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	47.7245
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.7791
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• opsin binding • protein binding • binding • arrestin family protein binding • G protein-coupled photoreceptor activity • molecular transducer activity • photoreceptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • vitamin binding • retinal binding • isoprenoid binding • retinoid binding • lipid binding • 11-cis retinal binding • small molecule binding • G-protein alpha-subunit binding • enzyme regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • hydrolase activity • guanyl ribonucleotide binding • GDP binding • purine ribonucleotide binding • ion binding • ribonucleoside triphosphate phosphatase activity • anion binding • molecular function regulator activity • heterocyclic compound binding • carbohydrate derivative binding • hydrolase activity, acting on acid anhydrides • catalytic activity • ribonucleotide binding • pyrophosphatase activity • GTPase activity • nucleoside-triphosphatase regulator activity • GTPase regulator activity • purine ribonucleoside triphosphate binding • guanyl-nucleotide exchange factor activity • nucleoside phosphate binding • purine nucleotide binding • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • cation binding • transition metal ion binding • zinc ion binding • metal ion binding • identical protein binding • multicellular organismal process • rod bipolar cell differentiation • cellular developmental process • sensory organ development • retina development in camera-type eye • visual system development • neural retina development • neurogenesis • multicellular organism development • eye morphogenesis • neuron differentiation • cell differentiation • anatomical structure development • animal organ morphogenesis
Gene Ontology	Biological Process	• multicellular organismal process • rod bipolar cell differentiation • cellular developmental process • sensory organ development • retina development in camera-type eye • visual system development • neural retina development • neurogenesis • multicellular organism development • eye morphogenesis • neuron differentiation • cell differentiation • anatomical structure development • animal organ morphogenesis • sensory system development • system development • developmental process • camera-type eye morphogenesis • eye development • animal organ development • nervous system development • retinal bipolar neuron differentiation • glutamatergic neuron differentiation • generation of neurons • retina morphogenesis in camera-type eye • anatomical structure morphogenesis • sensory organ morphogenesis • camera-type eye development • cellular process • cellular response to stimulus • response to light stimulus • response to stimulus • cellular response to light stimulus • response to radiation • response to abiotic stimulus • cellular response to radiation • cellular response to abiotic stimulus • cellular response to environmental stimulus • regulation of cellular process • signaling • detection of abiotic stimulus • cell communication • signal transduction • detection of light stimulus • phototransduction • detection of external stimulus • regulation of biological process • biological regulation • detection of visible light • response to external stimulus • detection of stimulus • G protein-coupled receptor signaling pathway • G protein-coupled opsin signaling pathway • phototransduction, visible light • response to light intensity • podosome assembly • organelle assembly • protein-containing complex organization • membraneless organelle assembly • cellular component organization • cellular component biogenesis • organelle organization • cellular component assembly • protein-containing complex assembly • cellular component organization or biogenesis • biosynthetic process • metabolic process • macromolecule metabolic process • gene expression • macromolecule biosynthetic process • multicellular organismal-level homeostasis • homeostatic process • anatomical structure homeostasis • tissue homeostasis • retina homeostasis • photoreceptor cell maintenance • absorption of visible light • light absorption • microtubule cytoskeleton organization • microtubule-based process • cytoskeleton organization • sensory perception of light stimulus • system process • sensory perception • nervous system process • visual perception • thermoception • sensory perception of temperature stimulus • detection of temperature stimulus involved in sensory perception • response to temperature stimulus • detection of temperature stimulus involved in thermoception • detection of temperature stimulus • detection of stimulus involved in sensory perception • taxis • thermotaxis • locomotion • cellular anatomical structure • membrane • cell-cell junction • anchoring junction • cell junction • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • cell-cell junction • anchoring junction • cell junction • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle • organelle membrane • cell periphery • protein-containing complex • plasma membrane protein complex • plasma membrane • plasma membrane signaling receptor complex • G protein-coupled receptor complex • membrane protein complex • receptor complex • sperm midpiece • 9+2 motile cilium • sperm flagellum • motile cilium • photoreceptor inner segment membrane • plasma membrane region • photoreceptor inner segment • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • cell projection membrane • Golgi membrane • intracellular anatomical structure • Golgi apparatus • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasm • outer membrane • sperm head • sperm head plasma membrane • sperm plasma membrane • rod photoreceptor outer segment • guanyl nucleotide binding • binding • nucleotide binding • GDP binding • guanyl ribonucleotide binding • purine ribonucleotide binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein binding • kinase binding • enzyme binding • protein kinase binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • signaling receptor binding • G protein-coupled receptor binding • acyl binding • GTP binding • purine ribonucleoside triphosphate binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • detection of light stimulus involved in visual perception • detection of light stimulus • response to light stimulus • multicellular organismal process • detection of external stimulus • sensory perception of light stimulus • system process • nervous system process • response to stimulus • response to external stimulus • detection of abiotic stimulus • detection of stimulus • sensory perception • detection of light stimulus involved in sensory perception • response to abiotic stimulus • response to radiation • visual perception • detection of stimulus involved in sensory perception • phototransduction • cellular response to stimulus • regulation of biological process • regulation of cellular process • signaling • biological regulation • detection of visible light • cell communication • cellular process • signal transduction • phototransduction, visible light • negative regulation of hydrolase activity • regulation of molecular function • regulation of catalytic activity • regulation of hydrolase activity • negative regulation of cyclic-nucleotide phosphodiesterase activity • negative regulation of molecular function • negative regulation of catalytic activity • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • extrinsic component of plasma membrane • catalytic complex • cytoplasmic side of membrane • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane
SCOP2	Domain Identifier	• G protein-coupled receptor-like
SCOP2	Family Identifier	• G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	RET
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	RET
Name	RETINAL
Synonyms
Identifier
Formula	C20 H28 O
Molecular Weight	284.436
SMILES
PubChem	638015
Formal Charge	0
Total Atoms	49
Total Chiral Atoms	0
Total Bonds	49
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P02699
Sequence	>3PQR_nogp_Chain_R M N G T E G P N F Y V P F S N K T G V V R S P F E A P Q Y Y L A E P W Q F S M L A A Y M F L L I M L G F P I N F L T L Y V T V Q H K K L R T P L N Y I L L N L A V A D L F M V F G G F T T T L Y T S L H G Y F V F G P T G C N L E G F F A T L G G E I A L W S L V V L A I E R Y V V V C K P M S N F R F G E N H A I M G V A F T W V M A L A C A A P P L V G W S R Y I P E G M Q C S C G I D Y Y T P H E E T N N E S F V I Y M F V V H F I I P L I V I F F C Y G Q L V F T V K E A A A Q Q Q E S A T T Q K A E K E V T R M V I I M V I A F L I C W L P Y A G V A F Y I F T H Q G S D F G P I F M T I P A F F A K T S A V Y N P V I Y I M M N K Q F R N C M V T T L C C G K N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8P15	A	Sensory	Opsin	Rhodopsin	Bos taurus	-	-	Gi1/β1/γT1	5.9	2024-11-20	To be published
	8P15 (No Gprot)	A	Sensory	Opsin	Rhodopsin	Bos taurus	-	-		5.9	2024-11-20	To be published
	8P13	A	Sensory	Opsin	Rhodopsin	Bos taurus	-	-	Gi1/β1/γT1	5.2	2024-11-20	To be published
	8P13 (No Gprot)	A	Sensory	Opsin	Rhodopsin	Bos taurus	-	-		5.2	2024-11-20	To be published
	8P12	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gi1/β1/γT1	3.21	2024-11-20	To be published
	8P12 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		3.21	2024-11-20	To be published
	9EPR	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	Retinal	-	Gi1/β1/γ2	4.9	2024-10-30	doi.org/10.1038/s41467-024-53208-2
	9EPR (No Gprot)	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	Retinal	-		4.9	2024-10-30	doi.org/10.1038/s41467-024-53208-2
	9EPQ	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	11,20-Ethanoretinal	-	chim(Gi1-CtGq)/β1/γ2	4.15	2024-10-23	10.1038/s41467-024-53208-2
	9EPQ (No Gprot)	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	11,20-Ethanoretinal	-		4.15	2024-10-23	10.1038/s41467-024-53208-2
	9EPP	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	11,20-Ethanoretinal	-	chim(Gi1-CtGq)/β1/γ2	4.06	2024-10-23	10.1038/s41467-024-53208-2
	9EPP (No Gprot)	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	11,20-Ethanoretinal	-		4.06	2024-10-23	10.1038/s41467-024-53208-2
	8FD1	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.25	2023-08-30	10.1038/s41467-023-40911-9
	8FD1 (Multimeric)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		4.25	2023-08-30	10.1038/s41467-023-40911-9
	8FD0	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	3.71	2023-08-30	10.1038/s41467-023-40911-9
	8FD0 (Multimeric)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		3.71	2023-08-30	10.1038/s41467-023-40911-9
	8FCZ	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	3.7	2023-08-30	10.1038/s41467-023-40911-9
	8FCZ (Multimeric)	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-		3.7	2023-08-30	10.1038/s41467-023-40911-9
	8A6E	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	1.8	2023-03-29	10.1038/s41586-023-05863-6
	8A6D	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	1.8	2023-03-29	10.1038/s41586-023-05863-6
	8A6C	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	1.8	2023-03-29	10.1038/s41586-023-05863-6
	7ZBE	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	1.8	2023-03-29	10.1038/s41586-023-05863-6
	7ZBC	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	1.8	2023-03-29	10.1038/s41586-023-05863-6
	7MTB	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	GRK1	4	2021-07-07	10.1038/s41586-021-03721-x
	7MTB (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		4	2021-07-07	10.1038/s41586-021-03721-x
	7MTA	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	GRK1	4.1	2021-07-07	10.1038/s41586-021-03721-x
	7MTA (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		4.1	2021-07-07	10.1038/s41586-021-03721-x
	7MT9	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	GRK1	7	2021-07-07	10.1038/s41586-021-03721-x
	7MT9 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		7	2021-07-07	10.1038/s41586-021-03721-x
	7MT8	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	GRK1	5.8	2021-07-07	10.1038/s41586-021-03721-x
	7MT8 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		5.8	2021-07-07	10.1038/s41586-021-03721-x
	6PH7	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Nerol	Gt(CT)	2.9	2020-07-01	To be published
	6PH7 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Nerol		2.9	2020-07-01	To be published
	6PGS	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Geraniol	Gt(CT)	2.9	2020-07-01	To be published
	6PGS (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Geraniol		2.9	2020-07-01	To be published
	6PEL	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Citronellol	Gt(CT)	3.19	2020-06-24	To be published
	6PEL (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Citronellol		3.19	2020-06-24	To be published
	6NWE	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Gt(CT)	2.71	2020-02-12	To be published
	6NWE (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-		2.71	2020-02-12	To be published
	6OFJ	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.5	2019-08-21	10.1074/jbc.RA119.010089
	6OFJ (Multimeric)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		4.5	2019-08-21	10.1074/jbc.RA119.010089
	6OYA	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt/β1/γ1	3.3	2019-07-24	10.1016/j.molcel.2019.06.007
	6OYA (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3.3	2019-07-24	10.1016/j.molcel.2019.06.007
	6OY9	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt/β1/γ1	3.9	2019-07-24	10.1016/j.molcel.2019.06.007
	6OY9 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3.9	2019-07-24	10.1016/j.molcel.2019.06.007
	6QNO	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gi1/β1/γ1	4.38	2019-07-10	10.7554/eLife.46041
	6QNO (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		4.38	2019-07-10	10.7554/eLife.46041
	6I9K	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	9-cis-Retinal	-	-	2.15	2019-07-03	10.1073/pnas.1902192116
	6FUF	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Go	3.12	2018-10-03	10.1126/sciadv.aat7052
	6FUF (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3.12	2018-10-03	10.1126/sciadv.aat7052
	6CMO	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-	Gi1/β1/γ2	4.5	2018-06-20	10.1038/s41586-018-0215-y
	6CMO (No Gprot)	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-		4.5	2018-06-20	10.1038/s41586-018-0215-y
	6FKD	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 137349183	-	2.49	2018-04-04	10.1073/pnas.1718084115
	6FKC	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473039	-	2.46	2018-04-04	10.1073/pnas.1718084115
	6FKB	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473038	-	3.03	2018-04-04	10.1073/pnas.1718084115
	6FKA	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473037	-	2.7	2018-04-04	10.1073/pnas.1718084115
	6FK9	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473036	-	2.63	2018-04-04	10.1073/pnas.1718084115
	6FK8	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473035	-	2.87	2018-04-04	10.1073/pnas.1718084115
	6FK7	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473034	-	2.62	2018-04-04	10.1073/pnas.1718084115
	6FK6	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473033	-	2.36	2018-04-04	10.1073/pnas.1718084115
	5WKT	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Gt(CT)	3.2	2017-12-13	10.1038/nprot.2017.135
	5WKT (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-		3.2	2017-12-13	10.1038/nprot.2017.135
	5W0P	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-	Arrestin1	3.01	2017-08-09	10.1016/j.cell.2017.07.002
	5TE5	A	Sensory	Opsins	Rhodopsin	Bos taurus	20-Methanoretinal	-	-	4.01	2017-03-15	10.1073/pnas.1617446114
	5TE3	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	-	2.7	2017-03-15	10.1073/pnas.1617446114
	5DYS	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	2.3	2016-08-10	10.15252/embr.201642671
	5EN0	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	2.81	2016-08-10	10.15252/embr.201642671
	5EN0 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		2.81	2016-08-10	10.15252/embr.201642671
	5DGY	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-	Arrestin1	7.7	2016-03-23	10.1038/sdata.2016.21
	4X1H	A	Sensory	Opsins	Rhodopsin	Bos taurus	Nonyl-β-D-Glucopyranoside	-	Gt(CT)	2.29	2015-11-04	10.1016/j.str.2015.09.015
	4X1H (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	Nonyl-β-D-Glucopyranoside	-		2.29	2015-11-04	10.1016/j.str.2015.09.015
	4ZWJ	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-	Arrestin1	3.3	2015-07-29	10.1038/nature14656
	4WW3	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	All-trans-Retinal	-	-	2.8	2015-06-17	10.1371/journal.pone.0126970
	4PXF	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Arrestin1 Finger Loop	2.75	2014-09-17	10.1038/ncomms5801
	4J4Q	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl β-D-Glucopyranoside	-	Gt(CT)	2.65	2013-10-30	10.1002/anie.201302374
	4J4Q (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl β-D-Glucopyranoside	-		2.65	2013-10-30	10.1002/anie.201302374
	4BEY	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gt(CT)	2.9	2013-05-08	10.1038/embor.2013.44
	4BEY (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		2.9	2013-05-08	10.1038/embor.2013.44
	4BEZ	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	3.3	2013-04-24	10.1038/embor.2013.44
	4A4M	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	3.3	2012-01-25	10.1073/pnas.1114089108
	4A4M (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3.3	2012-01-25	10.1073/pnas.1114089108
	3AYN	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	9-cis-Retinal	-	-	2.7	2011-08-17	10.1016/j.jmb.2011.08.044
	3AYM	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	All-trans-Retinal	-	-	2.8	2011-08-17	10.1016/j.jmb.2011.08.044
	2X72	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	3	2011-03-16	10.1038/nature09795
	2X72 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3	2011-03-16	10.1038/nature09795
	3PXO	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	3	2011-03-09	10.1038/nature09789
	3PQR	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	2.85	2011-03-09	10.1038/nature09789
	3PQR (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		2.85	2011-03-09	10.1038/nature09789
	3OAX	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.6	2011-01-19	10.1016/j.bpj.2010.08.003
	3DQB	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gt(CT)	3.2	2008-09-23	10.1038/nature07330
	3DQB (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		3.2	2008-09-23	10.1038/nature07330
	3C9M	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	3.4	2008-08-05	10.1107/S0907444908017162
	3C9L	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.65	2008-08-05	10.1107/S0907444908017162
	3CAP	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	2.9	2008-06-24	10.1038/nature07063
	3CAP (Multimeric)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		2.9	2008-06-24	10.1038/nature07063
	2Z73	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	11-cis-Retinal	-	-	2.5	2008-05-13	10.1038/nature06925
	2ZIY	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	11-cis-Retinal	-	-	3.7	2008-05-06	10.1074/jbc.C800040200
	2PED	A	Sensory	Opsins	Rhodopsin	Bos taurus	9-cis-Retinal	-	-	2.95	2007-10-30	10.1529/biophysj.107.108225
	2J4Y	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	3.4	2007-09-25	10.1016/j.jmb.2007.03.007
	2I37	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.15	2006-10-17	10.1073/pnas.0608022103
	2I36	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.1	2006-10-17	10.1073/pnas.0608022103
	2I35	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	3.8	2006-10-17	10.1073/pnas.0608022103
	2G87	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	2.6	2006-09-02	10.1002/anie.200600595
	2HPY	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	2.8	2006-08-22	10.1073/pnas.0601765103
	1U19	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.2	2004-10-12	10.1016/j.jmb.2004.07.044
	1GZM	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.65	2003-11-20	10.1016/j.jmb.2004.08.090
	1L9H	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.6	2002-05-15	10.1073/pnas.082666399
	1HZX	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.8	2001-07-04	10.1021/bi0155091
	1F88	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.8	2000-08-04	10.1126/science.289.5480.739

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 3PQR_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.