CodeRET
NameRETINAL
Synonyms
Identifier(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenal
FormulaC20 H28 O
Molecular Weight284.436
SMILESCC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C/C=O)/C)/C
PubChem638015
Formal Charge0
Total Atoms49
Total Chiral Atoms0
Total Bonds49
Total Aromatic Bonds0
Networks41
 missing image

This ligand is also present in the following 41 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
1F88 A Sensory Opsins Rhodopsin Bos taurus 11-cis-Retinal - - 2.8 2000-08-04 10.1126/science.289.5480.739

A 2D representation of the interactions of RET in 1F88
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F91 R:R:M44 6.22 1 Yes Yes 7 7 2 2
R:R:F293 R:R:M44 4.98 1 Yes Yes 5 7 2 2
R:R:K296 R:R:M44 4.32 1 Yes Yes 7 7 1 2
R:R:F91 R:R:K296 4.96 1 Yes Yes 7 7 2 1
R:R:E113 R:R:K296 5.4 0 No Yes 5 7 2 1
L:L:?6 R:R:A117 6.28 1 Yes No 0 5 0 1
R:R:T118 R:R:Y178 6.24 0 No Yes 4 3 1 2
L:L:?6 R:R:T118 8.81 1 Yes No 0 4 0 1
R:R:G121 R:R:W265 5.63 0 No Yes 7 8 2 1
R:R:E122 R:R:W126 6.54 1 Yes Yes 6 5 1 2
R:R:C167 R:R:E122 10.64 1 No Yes 5 6 2 1
R:R:E122 R:R:H211 9.85 1 Yes Yes 6 6 1 2
L:L:?6 R:R:E122 7.92 1 Yes Yes 0 6 0 1
R:R:H211 R:R:W126 8.46 1 Yes Yes 6 5 2 2
R:R:C167 R:R:M207 4.86 1 No Yes 5 5 2 1
R:R:C167 R:R:H211 16.22 1 No Yes 5 6 2 2
R:R:E181 R:R:Y191 5.61 1 Yes Yes 4 6 2 2
R:R:E181 R:R:Y268 10.1 1 Yes Yes 4 6 2 1
R:R:E181 R:R:M288 5.41 1 Yes No 4 4 2 2
R:R:F293 R:R:S186 3.96 1 Yes Yes 5 5 2 1
R:R:K296 R:R:S186 4.59 1 Yes Yes 7 5 1 1
L:L:?6 R:R:S186 4.99 1 Yes Yes 0 5 0 1
R:R:Y191 R:R:Y268 5.96 1 Yes Yes 6 6 2 1
R:R:F203 R:R:M207 6.22 1 Yes Yes 6 5 2 1
R:R:F208 R:R:M207 4.98 0 Yes Yes 5 5 2 1
L:L:?6 R:R:M207 3.76 1 Yes Yes 0 5 0 1
R:R:F208 R:R:F212 6.43 0 Yes Yes 5 8 2 1
R:R:F212 R:R:L216 4.87 0 Yes No 8 7 1 2
L:L:?6 R:R:F212 5.66 1 Yes Yes 0 8 0 1
R:R:F261 R:R:W265 13.03 0 Yes Yes 9 8 2 1
R:R:W265 R:R:Y268 4.82 1 Yes Yes 8 6 1 1
R:R:A295 R:R:W265 5.19 0 No Yes 8 8 2 1
R:R:S298 R:R:W265 8.65 0 No Yes 9 8 2 1
L:L:?6 R:R:W265 18.15 1 Yes Yes 0 8 0 1
R:R:M288 R:R:Y268 5.99 1 No Yes 4 6 2 1
L:L:?6 R:R:Y268 17.13 1 Yes Yes 0 6 0 1
R:R:F293 R:R:K296 12.41 1 Yes Yes 5 7 2 1
L:L:?6 R:R:K296 7.49 1 Yes Yes 0 7 0 1
R:R:A292 R:R:S186 3.42 0 No Yes 5 5 2 1
R:R:A269 R:R:F212 2.77 0 No Yes 7 8 2 1
R:R:F212 R:R:L266 2.44 0 Yes No 8 6 1 2
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub7.00
Average Interaction Strength8.91
Average Nodes In Shell31.00
Average Hubs In Shell19.00
Average Links In Shell41.00
Average Links Mediated by Hubs In Shell41.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
1GZM A Sensory Opsins Rhodopsin Bos taurus 11-cis-Retinal - - 2.65 2003-11-20 10.1016/j.jmb.2004.08.090

A 2D representation of the interactions of RET in 1GZM
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F91 R:R:M44 8.71 1 No Yes 7 7 2 2
R:R:M44 R:R:T94 10.54 1 Yes No 7 7 2 2
R:R:F293 R:R:M44 4.98 1 Yes Yes 5 7 2 2
R:R:K296 R:R:M44 4.32 1 Yes Yes 7 7 1 2
R:R:F91 R:R:K296 7.44 1 No Yes 7 7 2 1
R:R:E113 R:R:T94 12.7 1 Yes No 5 7 1 2
R:R:E113 R:R:S186 5.75 1 Yes No 5 5 1 2
R:R:E113 R:R:K296 6.75 1 Yes Yes 5 7 1 1
L:L:?2 R:R:E113 4.4 1 Yes Yes 0 5 0 1
L:L:?2 R:R:A117 5.23 1 Yes No 0 5 0 1
R:R:T118 R:R:Y178 9.99 0 No Yes 4 3 1 2
L:L:?2 R:R:T118 8.81 1 Yes No 0 4 0 1
R:R:G121 R:R:W265 5.63 0 No Yes 7 8 2 1
R:R:E122 R:R:L125 5.3 1 Yes No 6 7 1 2
R:R:E122 R:R:W126 6.54 1 Yes Yes 6 5 1 2
R:R:C167 R:R:E122 7.6 1 No Yes 5 6 2 1
R:R:E122 R:R:H211 8.62 1 Yes Yes 6 6 1 2
L:L:?2 R:R:E122 9.68 1 Yes Yes 0 6 0 1
R:R:F261 R:R:L125 10.96 0 Yes No 9 7 2 2
R:R:H211 R:R:W126 8.46 1 Yes Yes 6 5 2 2
R:R:C167 R:R:H211 16.22 1 No Yes 5 6 2 2
R:R:I189 R:R:Y178 6.04 1 Yes Yes 4 3 2 2
R:R:E181 R:R:Y191 4.49 1 Yes Yes 4 6 2 2
R:R:E181 R:R:Y268 10.1 1 Yes Yes 4 6 2 1
R:R:E181 R:R:M288 12.18 1 Yes No 4 4 2 2
R:R:F293 R:R:S186 7.93 1 Yes No 5 5 2 2
R:R:K296 R:R:S186 6.12 1 Yes No 7 5 1 2
R:R:I189 R:R:Y191 10.88 1 Yes Yes 4 6 2 2
R:R:F203 R:R:I189 11.3 1 Yes Yes 6 4 2 2
R:R:I189 R:R:M207 4.37 1 Yes Yes 4 5 2 1
R:R:Y191 R:R:Y268 8.94 1 Yes Yes 6 6 2 1
R:R:F203 R:R:M207 4.98 1 Yes Yes 6 5 2 1
R:R:F208 R:R:M207 7.46 0 No Yes 5 5 2 1
L:L:?2 R:R:M207 5.63 1 Yes Yes 0 5 0 1
R:R:F212 R:R:L216 4.87 0 No No 8 7 1 2
L:L:?2 R:R:F212 6.47 1 Yes No 0 8 0 1
R:R:F261 R:R:W265 14.03 0 Yes Yes 9 8 2 1
R:R:C264 R:R:W265 6.53 0 No Yes 8 8 2 1
R:R:A295 R:R:W265 7.78 0 No Yes 8 8 2 1
R:R:S298 R:R:W265 8.65 0 No Yes 9 8 2 1
L:L:?2 R:R:W265 19.67 1 Yes Yes 0 8 0 1
R:R:M288 R:R:Y268 11.97 1 No Yes 4 6 2 1
L:L:?2 R:R:Y268 19.46 1 Yes Yes 0 6 0 1
R:R:F293 R:R:K296 9.93 1 Yes Yes 5 7 2 1
L:L:?2 R:R:K296 8.43 1 Yes Yes 0 7 0 1
R:R:F212 R:R:I213 3.77 0 No No 8 4 1 2
R:R:A292 R:R:Y268 2.67 0 No Yes 5 6 2 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub6.00
Average Interaction Strength9.75
Average Nodes In Shell34.00
Average Hubs In Shell17.00
Average Links In Shell47.00
Average Links Mediated by Hubs In Shell45.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
1HZX A Sensory Opsins Rhodopsin Bos taurus 11-cis-Retinal - - 2.8 2001-07-04 10.1021/bi0155091

A 2D representation of the interactions of RET in 1HZX
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F91 R:R:M44 8.71 1 Yes Yes 7 7 2 2
R:R:M44 R:R:T94 7.53 1 Yes No 7 7 2 2
R:R:F293 R:R:M44 7.46 1 Yes Yes 5 7 2 2
R:R:K296 R:R:M44 4.32 1 Yes Yes 7 7 1 2
R:R:F91 R:R:T94 3.89 1 Yes No 7 7 2 2
R:R:F91 R:R:K296 6.2 1 Yes Yes 7 7 2 1
R:R:E113 R:R:T93 4.23 1 Yes No 5 5 1 2
R:R:E113 R:R:T94 11.29 1 Yes No 5 7 1 2
R:R:E113 R:R:F103 4.66 1 Yes Yes 5 8 1 2
R:R:E113 R:R:S186 4.31 1 Yes No 5 5 1 2
R:R:E113 R:R:K296 5.4 1 Yes Yes 5 7 1 1
L:L:?16 R:R:E113 6.16 1 Yes Yes 0 5 0 1
L:L:?16 R:R:A117 5.23 1 Yes No 0 5 0 1
R:R:T118 R:R:Y178 9.99 0 No Yes 4 3 1 2
L:L:?16 R:R:T118 12.73 1 Yes No 0 4 0 1
R:R:G121 R:R:W265 4.22 0 No Yes 7 8 2 1
R:R:E122 R:R:L125 3.98 1 Yes Yes 6 7 1 2
R:R:E122 R:R:W126 6.54 1 Yes Yes 6 5 1 2
R:R:C167 R:R:E122 7.6 1 No Yes 5 6 2 1
R:R:E122 R:R:H211 8.62 1 Yes Yes 6 6 1 2
L:L:?16 R:R:E122 7.92 1 Yes Yes 0 6 0 1
R:R:L125 R:R:L216 4.15 0 Yes No 7 7 2 2
R:R:F261 R:R:L125 10.96 1 Yes Yes 9 7 1 2
R:R:H211 R:R:W126 7.41 1 Yes Yes 6 5 2 2
R:R:F261 R:R:L128 4.87 1 Yes No 9 8 1 2
R:R:C167 R:R:M207 4.86 1 No No 5 5 2 1
R:R:C167 R:R:H211 16.22 1 No Yes 5 6 2 2
R:R:E181 R:R:Y191 4.49 1 Yes Yes 4 6 2 2
R:R:E181 R:R:Y268 10.1 1 Yes Yes 4 6 2 1
R:R:E181 R:R:M288 8.12 1 Yes Yes 4 4 2 2
R:R:F293 R:R:S186 5.28 1 Yes No 5 5 2 2
R:R:K296 R:R:S186 4.59 1 Yes No 7 5 1 2
R:R:Y191 R:R:Y268 4.96 1 Yes Yes 6 6 2 1
R:R:F203 R:R:M207 4.98 1 Yes No 6 5 2 1
L:L:?16 R:R:M207 3.76 1 Yes No 0 5 0 1
R:R:F208 R:R:F212 5.36 0 No Yes 5 8 2 1
R:R:F212 R:R:L216 4.87 0 Yes No 8 7 1 2
L:L:?16 R:R:F212 5.66 1 Yes Yes 0 8 0 1
R:R:F261 R:R:W265 15.03 1 Yes Yes 9 8 1 1
L:L:?16 R:R:F261 4.04 1 Yes Yes 0 9 0 1
R:R:C264 R:R:W265 3.92 0 No Yes 8 8 2 1
R:R:A295 R:R:W265 3.89 0 No Yes 8 8 2 1
R:R:S298 R:R:W265 8.65 0 No Yes 9 8 2 1
L:L:?16 R:R:W265 19.67 1 Yes Yes 0 8 0 1
R:R:M288 R:R:Y268 9.58 1 Yes Yes 4 6 2 1
L:L:?16 R:R:Y268 14.79 1 Yes Yes 0 6 0 1
R:R:F293 R:R:K296 13.65 1 Yes Yes 5 7 2 1
L:L:?16 R:R:K296 7.49 1 Yes Yes 0 7 0 1
R:R:A124 R:R:F261 2.77 0 No Yes 9 9 2 1
R:R:F212 R:R:L266 2.44 0 Yes No 8 6 1 2
L:L:?16 R:R:A269 2.09 1 Yes No 0 7 0 1
R:R:A269 R:R:G270 1.95 0 No No 7 5 1 2
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub7.00
Average Interaction Strength8.14
Average Nodes In Shell38.00
Average Hubs In Shell20.00
Average Links In Shell52.00
Average Links Mediated by Hubs In Shell50.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
1L9H A Sensory Opsins Rhodopsin Bos taurus 11-cis-Retinal - - 2.6 2002-05-15 10.1073/pnas.082666399

A 2D representation of the interactions of RET in 1L9H
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F91 R:R:M44 6.22 1 Yes Yes 7 7 2 2
R:R:M44 R:R:T94 9.03 1 Yes Yes 7 7 2 2
R:R:F293 R:R:M44 6.22 1 Yes Yes 5 7 2 2
R:R:K296 R:R:M44 5.76 1 Yes Yes 7 7 1 2
R:R:F91 R:R:T94 3.89 1 Yes Yes 7 7 2 2
R:R:F91 R:R:K296 6.2 1 Yes Yes 7 7 2 1
R:R:E113 R:R:T94 9.88 1 Yes Yes 5 7 1 2
R:R:K296 R:R:T94 4.5 1 Yes Yes 7 7 1 2
R:R:E113 R:R:F103 7 1 Yes Yes 5 8 1 2
R:R:E113 R:R:S186 4.31 1 Yes No 5 5 1 2
R:R:E113 R:R:K296 6.75 1 Yes Yes 5 7 1 1
L:L:?19 R:R:E113 5.28 1 Yes Yes 0 5 0 1
L:L:?19 R:R:A117 5.23 1 Yes No 0 5 0 1
R:R:T118 R:R:Y178 6.24 0 No Yes 4 3 1 2
L:L:?19 R:R:T118 8.81 1 Yes No 0 4 0 1
R:R:E122 R:R:L125 6.63 1 Yes Yes 6 7 1 2
R:R:E122 R:R:W126 6.54 1 Yes Yes 6 5 1 2
R:R:C167 R:R:E122 7.6 1 No Yes 5 6 2 1
R:R:E122 R:R:H211 7.39 1 Yes Yes 6 6 1 2
L:L:?19 R:R:E122 7.04 1 Yes Yes 0 6 0 1
R:R:F261 R:R:L125 9.74 0 Yes Yes 9 7 2 2
R:R:H211 R:R:W126 8.46 1 Yes Yes 6 5 2 2
R:R:C167 R:R:H211 14.74 1 No Yes 5 6 2 2
R:R:E181 R:R:Y268 8.98 1 Yes Yes 4 6 2 1
R:R:E181 R:R:M288 6.77 1 Yes Yes 4 4 2 2
R:R:F293 R:R:S186 6.61 1 Yes No 5 5 2 2
R:R:Y191 R:R:Y268 4.96 0 Yes Yes 6 6 2 1
R:R:F208 R:R:F212 5.36 0 No Yes 5 8 2 1
R:R:A269 R:R:F212 4.16 0 No Yes 7 8 2 1
L:L:?19 R:R:F212 5.66 1 Yes Yes 0 8 0 1
R:R:F261 R:R:W265 14.03 0 Yes Yes 9 8 2 1
R:R:C264 R:R:W265 3.92 0 No Yes 8 8 2 1
R:R:W265 R:R:Y268 4.82 1 Yes Yes 8 6 1 1
R:R:A295 R:R:W265 7.78 0 No Yes 8 8 2 1
R:R:S298 R:R:W265 7.41 0 No Yes 9 8 2 1
L:L:?19 R:R:W265 17.4 1 Yes Yes 0 8 0 1
R:R:M288 R:R:Y268 9.58 1 Yes Yes 4 6 2 1
L:L:?19 R:R:Y268 14.01 1 Yes Yes 0 6 0 1
R:R:F293 R:R:K296 11.17 1 Yes Yes 5 7 2 1
L:L:?19 R:R:K296 7.49 1 Yes Yes 0 7 0 1
R:R:A168 R:R:T118 3.36 0 No No 7 4 2 1
R:R:G121 R:R:W265 2.81 0 No Yes 7 8 2 1
R:R:F212 R:R:L266 2.44 0 Yes No 8 6 1 2
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub6.00
Average Interaction Strength8.86
Average Nodes In Shell32.00
Average Hubs In Shell20.00
Average Links In Shell43.00
Average Links Mediated by Hubs In Shell42.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
1U19 A Sensory Opsins Rhodopsin Bos taurus 11-cis-Retinal - - 2.2 2004-10-12 10.1016/j.jmb.2004.07.044

A 2D representation of the interactions of RET in 1U19
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F91 R:R:M44 8.71 1 Yes Yes 7 7 2 2
R:R:F293 R:R:M44 4.98 1 Yes Yes 5 7 2 2
R:R:K296 R:R:M44 4.32 1 Yes Yes 7 7 1 2
R:R:F91 R:R:K296 7.44 1 Yes Yes 7 7 2 1
R:R:E113 R:R:K296 5.4 0 Yes Yes 5 7 2 1
L:L:?9 R:R:A117 5.23 1 Yes No 0 5 0 1
R:R:T118 R:R:Y178 8.74 0 No Yes 4 3 1 2
L:L:?9 R:R:T118 7.83 1 Yes No 0 4 0 1
R:R:G121 R:R:W265 5.63 0 No Yes 7 8 2 1
R:R:E122 R:R:L125 6.63 1 Yes No 6 7 1 2
R:R:E122 R:R:W126 4.36 1 Yes Yes 6 5 1 2
R:R:C167 R:R:E122 4.56 1 No Yes 5 6 2 1
R:R:E122 R:R:H211 7.39 1 Yes Yes 6 6 1 2
L:L:?9 R:R:E122 6.16 1 Yes Yes 0 6 0 1
R:R:F261 R:R:L125 7.31 0 Yes No 9 7 2 2
R:R:H211 R:R:W126 8.46 1 Yes Yes 6 5 2 2
R:R:C167 R:R:H211 14.74 1 No Yes 5 6 2 2
R:R:E181 R:R:Y191 5.61 1 Yes Yes 4 6 2 2
R:R:E181 R:R:Y268 8.98 1 Yes Yes 4 6 2 1
R:R:E181 R:R:M288 8.12 1 Yes Yes 4 4 2 2
R:R:Y191 R:R:Y268 7.94 1 Yes Yes 6 6 2 1
R:R:F208 R:R:F212 4.29 0 No Yes 5 8 2 1
R:R:F212 R:R:L216 6.09 0 Yes No 8 7 1 2
L:L:?9 R:R:F212 6.47 1 Yes Yes 0 8 0 1
R:R:F261 R:R:W265 16.04 0 Yes Yes 9 8 2 1
R:R:C264 R:R:W265 6.53 0 No Yes 8 8 2 1
R:R:W265 R:R:Y268 4.82 1 Yes Yes 8 6 1 1
R:R:A295 R:R:W265 7.78 0 No Yes 8 8 2 1
R:R:S298 R:R:W265 8.65 0 No Yes 9 8 2 1
L:L:?9 R:R:W265 14.37 1 Yes Yes 0 8 0 1
R:R:M288 R:R:Y268 9.58 1 Yes Yes 4 6 2 1
L:L:?9 R:R:Y268 17.91 1 Yes Yes 0 6 0 1
R:R:F293 R:R:K296 9.93 1 Yes Yes 5 7 2 1
L:L:?9 R:R:K296 7.49 1 Yes Yes 0 7 0 1
R:R:A168 R:R:T118 3.36 0 No No 7 4 2 1
L:L:?9 R:R:A269 3.14 1 Yes No 0 7 0 1
R:R:F212 R:R:L266 2.44 0 Yes No 8 6 1 2
R:R:A269 R:R:G270 1.95 0 No No 7 5 1 2
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub5.00
Average Interaction Strength8.57
Average Nodes In Shell31.00
Average Hubs In Shell17.00
Average Links In Shell38.00
Average Links Mediated by Hubs In Shell36.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
2G87 A Sensory Opsins Rhodopsin Bos taurus All-trans-retinal - - 2.6 2006-09-02 10.1002/anie.200600595

A 2D representation of the interactions of RET in 2G87
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F91 R:R:M44 6.22 1 Yes Yes 7 7 2 2
R:R:M44 R:R:T94 6.02 1 Yes Yes 7 7 2 2
R:R:K296 R:R:M44 4.32 1 Yes Yes 7 7 1 2
R:R:F91 R:R:T94 3.89 1 Yes Yes 7 7 2 2
R:R:F91 R:R:K296 8.69 1 Yes Yes 7 7 2 1
R:R:E113 R:R:T94 12.7 1 Yes Yes 5 7 2 2
R:R:K296 R:R:T94 4.5 1 Yes Yes 7 7 1 2
R:R:E113 R:R:K296 5.4 1 Yes Yes 5 7 2 1
L:L:?9 R:R:A117 5.23 1 Yes No 0 5 0 1
R:R:T118 R:R:Y178 8.74 0 No Yes 4 3 1 2
L:L:?9 R:R:T118 5.87 1 Yes No 0 4 0 1
R:R:G121 R:R:W265 4.22 0 No Yes 7 8 2 1
R:R:E122 R:R:L125 6.63 1 Yes No 6 7 1 2
R:R:E122 R:R:W126 4.36 1 Yes Yes 6 5 1 2
R:R:C167 R:R:E122 4.56 1 No Yes 5 6 2 1
R:R:E122 R:R:H211 6.15 1 Yes Yes 6 6 1 2
L:L:?9 R:R:E122 7.92 1 Yes Yes 0 6 0 1
R:R:F261 R:R:L125 7.31 0 Yes No 9 7 2 2
R:R:H211 R:R:W126 8.46 1 Yes Yes 6 5 2 2
R:R:C167 R:R:H211 14.74 1 No Yes 5 6 2 2
R:R:E181 R:R:Y191 4.49 1 Yes Yes 4 6 2 2
R:R:E181 R:R:Y268 8.98 1 Yes Yes 4 6 2 1
R:R:E181 R:R:M288 8.12 1 Yes Yes 4 4 2 2
R:R:Y191 R:R:Y268 6.95 1 Yes Yes 6 6 2 1
R:R:F208 R:R:F212 4.29 0 No Yes 5 8 2 1
R:R:F212 R:R:L216 4.87 0 Yes No 8 7 1 2
L:L:?9 R:R:F212 9.71 1 Yes Yes 0 8 0 1
R:R:F261 R:R:W265 14.03 0 Yes Yes 9 8 2 1
R:R:C264 R:R:W265 6.53 0 No Yes 8 8 2 1
R:R:W265 R:R:Y268 4.82 1 Yes Yes 8 6 1 1
R:R:A295 R:R:W265 7.78 0 No Yes 8 8 2 1
R:R:S298 R:R:W265 7.41 0 No Yes 9 8 2 1
L:L:?9 R:R:W265 12.86 1 Yes Yes 0 8 0 1
R:R:M288 R:R:Y268 11.97 1 Yes Yes 4 6 2 1
L:L:?9 R:R:Y268 17.13 1 Yes Yes 0 6 0 1
L:L:?9 R:R:K296 8.43 1 Yes Yes 0 7 0 1
L:L:?9 R:R:A269 3.14 1 Yes No 0 7 0 1
R:R:F212 R:R:L266 2.44 0 Yes No 8 6 1 2
R:R:A269 R:R:G270 1.95 0 No No 7 5 1 2
R:R:F212 R:R:I213 1.26 0 Yes No 8 4 1 2
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub5.00
Average Interaction Strength8.79
Average Nodes In Shell31.00
Average Hubs In Shell17.00
Average Links In Shell40.00
Average Links Mediated by Hubs In Shell39.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
2HPY A Sensory Opsins Rhodopsin Bos taurus All-trans-retinal - - 2.8 2006-08-22 10.1073/pnas.0601765103

A 2D representation of the interactions of RET in 2HPY
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F91 R:R:M44 4.98 9 Yes Yes 7 7 2 2
R:R:F293 R:R:M44 4.98 9 Yes Yes 5 7 2 2
R:R:K296 R:R:M44 5.76 9 Yes Yes 7 7 1 2
R:R:F91 R:R:K296 4.96 9 Yes Yes 7 7 2 1
L:L:?8 R:R:A117 4.19 0 Yes No 0 5 0 1
R:R:T118 R:R:Y178 9.99 0 No Yes 4 3 1 2
L:L:?8 R:R:T118 8.81 0 Yes No 0 4 0 1
R:R:C167 R:R:E122 12.15 1 No No 5 6 2 1
R:R:E122 R:R:H211 7.39 1 No Yes 6 6 1 2
L:L:?8 R:R:E122 17.6 0 Yes No 0 6 0 1
R:R:C167 R:R:H211 11.79 1 No Yes 5 6 2 2
R:R:F212 R:R:L216 12.18 0 No No 8 7 1 2
L:L:?8 R:R:F212 5.66 0 Yes No 0 8 0 1
R:R:F261 R:R:W265 20.04 0 No Yes 9 8 2 1
R:R:C264 R:R:W265 10.45 0 No Yes 8 8 2 1
R:R:A295 R:R:W265 5.19 0 No Yes 8 8 2 1
R:R:S298 R:R:W265 4.94 0 No Yes 9 8 2 1
L:L:?8 R:R:W265 4.54 0 Yes Yes 0 8 0 1
R:R:F293 R:R:K296 6.2 9 Yes Yes 5 7 2 1
L:L:?8 R:R:K296 8.43 0 Yes Yes 0 7 0 1
R:R:A168 R:R:T118 3.36 0 No No 7 4 2 1
R:R:G121 R:R:W265 2.81 0 No Yes 7 8 2 1
R:R:A269 R:R:F212 2.77 0 No No 7 8 2 1
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub2.00
Average Interaction Strength8.21
Average Nodes In Shell21.00
Average Hubs In Shell8.00
Average Links In Shell23.00
Average Links Mediated by Hubs In Shell19.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
2I35 A Sensory Opsins Rhodopsin Bos taurus 11-cis-Retinal - - 3.8 2006-10-17 10.1073/pnas.0608022103

A 2D representation of the interactions of RET in 2I35
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F91 R:R:K296 8.69 8 Yes No 7 7 2 1
R:R:E113 R:R:K296 6.75 0 Yes No 5 7 2 1
L:L:?2 R:R:A117 4.19 1 Yes No 0 5 0 1
R:R:T118 R:R:Y178 9.99 0 No Yes 4 3 1 2
L:L:?2 R:R:T118 13.71 1 Yes No 0 4 0 1
R:R:E122 R:R:L125 5.3 1 Yes No 6 7 1 2
R:R:C167 R:R:E122 9.12 1 No Yes 5 6 2 1
R:R:E122 R:R:H211 7.39 1 Yes Yes 6 6 1 2
L:L:?2 R:R:E122 5.28 1 Yes Yes 0 6 0 1
R:R:F261 R:R:L125 8.53 0 Yes No 9 7 2 2
R:R:C167 R:R:H211 16.22 1 No Yes 5 6 2 2
R:R:E181 R:R:Y191 4.49 1 Yes Yes 4 6 2 2
R:R:E181 R:R:Y268 10.1 1 Yes Yes 4 6 2 1
R:R:E181 R:R:M288 10.83 1 Yes Yes 4 4 2 2
R:R:Y191 R:R:Y268 4.96 1 Yes Yes 6 6 2 1
R:R:M288 R:R:Y191 3.59 1 Yes Yes 4 6 2 2
R:R:F212 R:R:I213 3.77 0 No No 8 4 1 2
R:R:F212 R:R:L216 6.09 0 No No 8 7 1 2
L:L:?2 R:R:F212 5.66 1 Yes No 0 8 0 1
R:R:F261 R:R:W265 8.02 0 Yes Yes 9 8 2 1
R:R:W265 R:R:Y268 3.86 1 Yes Yes 8 6 1 1
R:R:A295 R:R:W265 7.78 0 No Yes 8 8 2 1
R:R:S298 R:R:W265 9.88 0 No Yes 9 8 2 1
L:L:?2 R:R:W265 8.32 1 Yes Yes 0 8 0 1
R:R:M288 R:R:Y268 9.58 1 Yes Yes 4 6 2 1
L:L:?2 R:R:Y268 15.57 1 Yes Yes 0 6 0 1
L:L:?2 R:R:K296 8.43 1 Yes No 0 7 0 1
L:L:?2 R:R:A269 2.09 1 Yes No 0 7 0 1
R:R:A269 R:R:G270 1.95 0 No No 7 5 1 2
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub3.00
Average Interaction Strength7.91
Average Nodes In Shell24.00
Average Hubs In Shell12.00
Average Links In Shell29.00
Average Links Mediated by Hubs In Shell26.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
2J4Y A Sensory Opsins Rhodopsin Bos taurus 11-cis-Retinal - - 3.4 2007-09-25 10.1016/j.jmb.2007.03.007

A 2D representation of the interactions of RET in 2J4Y
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F91 R:R:M44 8.71 1 No Yes 7 7 2 2
R:R:M44 R:R:T94 4.52 1 Yes No 7 7 2 2
R:R:F293 R:R:M44 4.98 1 Yes Yes 5 7 2 2
R:R:K296 R:R:M44 4.32 1 Yes Yes 7 7 1 2
R:R:F91 R:R:K296 8.69 1 No Yes 7 7 2 1
R:R:E113 R:R:T94 9.88 0 Yes No 5 7 1 2
R:R:E113 R:R:G114 4.91 0 Yes No 5 5 1 2
R:R:C187 R:R:E113 4.56 2 Yes Yes 9 5 2 1
L:L:?2 R:R:E113 6.16 1 Yes Yes 0 5 0 1
R:R:G114 R:R:Y178 7.24 0 No Yes 5 3 2 2
L:L:?2 R:R:A117 5.23 1 Yes No 0 5 0 1
R:R:T118 R:R:Y178 8.74 0 No Yes 4 3 1 2
L:L:?2 R:R:T118 8.81 1 Yes No 0 4 0 1
R:R:G121 R:R:W265 5.63 0 No Yes 7 8 2 1
R:R:I189 R:R:Y178 7.25 1 Yes Yes 4 3 2 2
R:R:E181 R:R:Y191 5.61 1 Yes Yes 4 6 2 1
R:R:E181 R:R:Y268 14.59 1 Yes Yes 4 6 2 1
R:R:E181 R:R:M288 12.18 1 Yes Yes 4 4 2 2
R:R:I189 R:R:Y191 9.67 1 Yes Yes 4 6 2 1
R:R:Y191 R:R:Y268 11.91 1 Yes Yes 6 6 1 1
R:R:A272 R:R:Y191 8.01 0 No Yes 5 6 2 1
L:L:?2 R:R:Y191 5.45 1 Yes Yes 0 6 0 1
R:R:F261 R:R:W265 15.03 0 No Yes 9 8 2 1
R:R:S298 R:R:W265 9.88 0 No Yes 9 8 2 1
L:L:?2 R:R:W265 18.15 1 Yes Yes 0 8 0 1
R:R:M288 R:R:Y268 4.79 1 Yes Yes 4 6 2 1
L:L:?2 R:R:Y268 15.57 1 Yes Yes 0 6 0 1
R:R:F293 R:R:K296 7.44 1 Yes Yes 5 7 2 1
L:L:?2 R:R:K296 8.43 1 Yes Yes 0 7 0 1
R:R:C264 R:R:W265 3.92 0 No Yes 8 8 2 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub5.00
Average Interaction Strength9.69
Average Nodes In Shell23.00
Average Hubs In Shell13.00
Average Links In Shell30.00
Average Links Mediated by Hubs In Shell30.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
2PED A Sensory Opsins Rhodopsin Bos taurus 9-cis-Retinal - - 2.95 2007-10-30 10.1529/biophysj.107.108225

A 2D representation of the interactions of RET in 2PED
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F91 R:R:M44 6.22 1 Yes Yes 7 7 2 2
R:R:F293 R:R:M44 4.98 1 Yes Yes 5 7 2 2
R:R:K296 R:R:M44 4.32 1 Yes Yes 7 7 1 2
R:R:F91 R:R:K296 6.2 1 Yes Yes 7 7 2 1
R:R:E113 R:R:S186 4.31 1 Yes No 5 5 2 2
R:R:E113 R:R:K296 6.75 1 Yes Yes 5 7 2 1
L:L:?8 R:R:A117 5.23 0 Yes No 0 5 0 1
R:R:T118 R:R:Y178 6.24 0 No Yes 4 3 1 2
L:L:?8 R:R:T118 13.71 0 Yes No 0 4 0 1
R:R:G121 R:R:W265 5.63 0 No Yes 7 8 2 1
R:R:E122 R:R:L125 6.63 3 Yes No 6 7 1 2
R:R:E122 R:R:W126 5.45 3 Yes Yes 6 5 1 2
R:R:E122 R:R:H211 7.39 3 Yes Yes 6 6 1 2
L:L:?8 R:R:E122 7.92 0 Yes Yes 0 6 0 1
R:R:F261 R:R:L125 10.96 0 No No 9 7 2 2
R:R:H211 R:R:W126 5.29 3 Yes Yes 6 5 2 2
R:R:C167 R:R:M207 4.86 3 Yes Yes 5 5 2 1
R:R:C167 R:R:H211 11.79 3 Yes Yes 5 6 2 2
R:R:E181 R:R:Y191 6.73 4 Yes Yes 4 6 2 2
R:R:E181 R:R:Y268 10.1 4 Yes Yes 4 6 2 1
R:R:E181 R:R:M288 13.53 4 Yes Yes 4 4 2 2
R:R:F293 R:R:S186 5.28 1 Yes No 5 5 2 2
R:R:K296 R:R:S186 4.59 1 Yes No 7 5 1 2
R:R:Y191 R:R:Y268 6.95 4 Yes Yes 6 6 2 1
R:R:F208 R:R:M207 7.46 0 No Yes 5 5 2 1
R:R:H211 R:R:M207 3.94 3 Yes Yes 6 5 2 1
L:L:?8 R:R:M207 4.69 0 Yes Yes 0 5 0 1
R:R:F208 R:R:F212 5.36 0 No Yes 5 8 2 1
L:L:?8 R:R:F212 5.66 0 Yes Yes 0 8 0 1
R:R:F261 R:R:W265 14.03 0 No Yes 9 8 2 1
R:R:C264 R:R:W265 3.92 0 No Yes 8 8 2 1
R:R:A295 R:R:W265 7.78 0 No Yes 8 8 2 1
R:R:S298 R:R:W265 7.41 0 No Yes 9 8 2 1
L:L:?8 R:R:W265 15.89 0 Yes Yes 0 8 0 1
R:R:M288 R:R:Y268 9.58 4 Yes Yes 4 6 2 1
L:L:?8 R:R:Y268 17.91 0 Yes Yes 0 6 0 1
R:R:F293 R:R:K296 9.93 1 Yes Yes 5 7 2 1
L:L:?8 R:R:K296 8.43 0 Yes Yes 0 7 0 1
L:L:?8 R:R:A269 3.14 0 Yes No 0 7 0 1
R:R:F212 R:R:I213 2.51 0 Yes No 8 4 1 2
R:R:F212 R:R:L216 2.44 0 Yes No 8 7 1 2
R:R:A269 R:R:G270 1.95 0 No No 7 5 1 2
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub6.00
Average Interaction Strength9.18
Average Nodes In Shell32.00
Average Hubs In Shell18.00
Average Links In Shell42.00
Average Links Mediated by Hubs In Shell40.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
2X72 A Sensory Opsins Rhodopsin Bos taurus All-trans-retinal - Gt(CT) 3 2011-03-16 10.1038/nature09795

A 2D representation of the interactions of RET in 2X72
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:T118 R:R:Y178 8.74 1 Yes Yes 4 3 1 2
R:R:I189 R:R:T118 4.56 1 No Yes 4 4 1 1
L:L:?6 R:R:T118 6.85 1 Yes Yes 0 4 0 1
R:R:C167 R:R:M207 6.48 1 No Yes 5 5 2 1
R:R:C167 R:R:H211 13.27 1 No Yes 5 6 2 2
R:R:E181 R:R:G188 4.91 0 No No 4 5 2 1
L:L:?6 R:R:G188 4.54 1 Yes No 0 5 0 1
R:R:F203 R:R:I189 5.02 1 Yes No 6 4 2 1
L:L:?6 R:R:I189 5.69 1 Yes No 0 4 0 1
R:R:Y191 R:R:Y192 10.92 1 Yes Yes 6 5 1 2
R:R:Y191 R:R:Y268 4.96 1 Yes Yes 6 6 1 1
L:L:?6 R:R:Y191 7.01 1 Yes Yes 0 6 0 1
R:R:F203 R:R:Y206 6.19 1 Yes Yes 6 4 2 2
R:R:F203 R:R:M207 7.46 1 Yes Yes 6 5 2 1
R:R:M207 R:R:Y206 3.59 1 Yes Yes 5 4 1 2
R:R:H211 R:R:Y206 9.8 1 Yes Yes 6 4 2 2
R:R:H211 R:R:M207 3.94 1 Yes Yes 6 5 2 1
L:L:?6 R:R:M207 6.57 1 Yes Yes 0 5 0 1
R:R:F208 R:R:I213 6.28 0 No No 5 4 1 2
L:L:?6 R:R:F208 5.66 1 Yes No 0 5 0 1
R:R:W265 R:R:Y268 3.86 1 Yes Yes 8 6 2 1
R:R:P291 R:R:Y268 11.13 0 No Yes 6 6 2 1
L:L:?6 R:R:Y268 12.46 1 Yes Yes 0 6 0 1
L:L:?6 R:R:A272 4.19 1 Yes No 0 5 0 1
R:R:A168 R:R:T118 3.36 0 No Yes 7 4 2 1
L:L:?6 R:R:A117 3.14 1 Yes No 0 5 0 1
R:R:A292 R:R:Y268 2.67 0 No Yes 5 6 2 1
R:R:A295 R:R:Y268 2.67 0 No Yes 8 6 2 1
R:R:V204 R:R:Y191 2.52 0 No Yes 4 6 2 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub4.00
Average Interaction Strength6.23
Average Nodes In Shell24.00
Average Hubs In Shell11.00
Average Links In Shell29.00
Average Links Mediated by Hubs In Shell27.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
2Z73 A Sensory Opsins Rhodopsin Todarodes pacificus 11-cis-Retinal - - 2.5 2008-05-13 10.1038/nature06925

A 2D representation of the interactions of RET in 2Z73
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:I41 R:R:K305 5.82 0 Yes Yes 5 7 2 1
R:R:N185 R:R:Y111 6.98 1 Yes Yes 4 5 2 2
R:R:K305 R:R:Y111 7.17 1 Yes Yes 7 5 1 2
L:L:?2 R:R:G116 5.68 0 Yes No 0 4 0 1
R:R:F120 R:R:M204 4.98 0 Yes No 6 5 1 2
R:R:F120 R:R:G208 4.52 0 Yes No 6 5 1 2
L:L:?2 R:R:F120 9.71 0 Yes Yes 0 6 0 1
R:R:E180 R:R:N185 9.2 1 Yes Yes 3 4 2 2
R:R:E180 R:R:S187 8.62 1 Yes No 3 3 2 1
R:R:E180 R:R:Y277 11.22 1 Yes Yes 3 6 2 2
R:R:E180 R:R:V301 5.7 1 Yes No 3 6 2 2
R:R:K305 R:R:N185 8.39 1 Yes Yes 7 4 1 2
R:R:S187 R:R:Y277 5.09 1 No Yes 3 6 1 2
L:L:?2 R:R:S187 8.98 0 Yes No 0 3 0 1
R:R:F188 R:R:M204 8.71 0 No No 5 5 1 2
L:L:?2 R:R:F188 10.52 0 Yes No 0 5 0 1
R:R:F205 R:R:L282 13.4 0 No No 5 6 1 2
L:L:?2 R:R:F205 11.32 0 Yes No 0 5 0 1
R:R:F209 R:R:I213 10.05 0 No No 7 5 1 2
L:L:?2 R:R:F209 12.94 0 Yes No 0 7 0 1
R:R:F270 R:R:W274 19.04 0 No Yes 9 8 2 1
R:R:A304 R:R:W274 6.48 0 No Yes 7 8 2 1
R:R:S307 R:R:W274 4.94 12 No Yes 9 8 2 1
L:L:?2 R:R:W274 16.64 0 Yes Yes 0 8 0 1
R:R:V301 R:R:Y277 12.62 1 No Yes 6 6 2 2
R:R:K305 R:R:V301 6.07 1 Yes No 7 6 1 2
L:L:?2 R:R:K305 7.49 0 Yes Yes 0 7 0 1
L:L:?2 R:R:A278 3.14 0 Yes No 0 7 0 1
R:R:A167 R:R:F120 2.77 0 No Yes 7 6 2 1
R:R:F209 R:R:S275 2.64 0 No No 7 6 1 2
R:R:G119 R:R:W274 1.41 0 No Yes 7 8 2 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub3.00
Average Interaction Strength9.60
Average Nodes In Shell26.00
Average Hubs In Shell9.00
Average Links In Shell31.00
Average Links Mediated by Hubs In Shell27.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
2ZIY A Sensory Opsins Rhodopsin Todarodes pacificus 11-cis-Retinal - - 3.7 2008-05-06 10.1074/jbc.C800040200

A 2D representation of the interactions of RET in 2ZIY
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F83 R:R:N87 26.58 1 Yes Yes 7 4 2 2
R:R:F83 R:R:W274 4.01 1 Yes Yes 7 8 2 1
R:R:F83 R:R:K305 4.96 1 Yes Yes 7 7 2 1
R:R:N87 R:R:Y111 10.47 1 Yes Yes 4 5 2 1
R:R:K305 R:R:N87 6.99 1 Yes Yes 7 4 1 2
R:R:M92 R:R:Y111 5.99 0 No Yes 6 5 2 1
R:R:M92 R:R:N185 8.41 0 No Yes 6 4 2 2
R:R:W101 R:R:Y111 3.86 1 Yes Yes 8 5 2 1
R:R:C186 R:R:W101 10.45 1 No Yes 9 8 2 2
R:R:C186 R:R:Y111 5.38 1 No Yes 9 5 2 1
R:R:K305 R:R:Y111 9.55 1 Yes Yes 7 5 1 1
L:L:?1 R:R:Y111 3.89 1 Yes Yes 0 5 0 1
R:R:F120 R:R:G208 4.52 0 Yes No 6 5 1 2
L:L:?1 R:R:F120 7.28 1 Yes Yes 0 6 0 1
R:R:F209 R:R:I123 3.77 0 Yes No 7 7 1 2
R:R:F270 R:R:I123 15.07 0 No No 9 7 2 2
R:R:E180 R:R:N185 13.15 1 Yes Yes 3 4 2 2
R:R:E180 R:R:S187 10.06 1 Yes Yes 3 3 2 1
R:R:E180 R:R:Y277 10.1 1 Yes Yes 3 6 2 2
R:R:K305 R:R:N185 8.39 1 Yes Yes 7 4 1 2
R:R:F188 R:R:S187 3.96 1 Yes Yes 5 3 2 1
R:R:S187 R:R:Y277 5.09 1 Yes Yes 3 6 1 2
L:L:?1 R:R:S187 5.98 1 Yes Yes 0 3 0 1
R:R:F188 R:R:Y277 4.13 1 Yes Yes 5 6 2 2
R:R:F209 R:R:F210 7.5 0 Yes No 7 4 1 2
R:R:F209 R:R:I213 3.77 0 Yes No 7 5 1 2
L:L:?1 R:R:F209 11.32 1 Yes Yes 0 7 0 1
R:R:F270 R:R:W274 14.03 0 No Yes 9 8 2 1
R:R:A304 R:R:W274 10.37 0 No Yes 7 8 2 1
R:R:S307 R:R:W274 7.41 0 No Yes 9 8 2 1
L:L:?1 R:R:W274 12.86 1 Yes Yes 0 8 0 1
L:L:?1 R:R:K305 7.49 1 Yes Yes 0 7 0 1
R:R:F120 R:R:G116 3.01 0 Yes No 6 4 1 2
R:R:A167 R:R:F120 2.77 0 No Yes 7 6 2 1
L:L:?1 R:R:A278 2.09 1 Yes No 0 7 0 1
R:R:A278 R:R:S275 1.71 0 No No 7 6 1 2
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub6.00
Average Interaction Strength7.27
Average Nodes In Shell27.00
Average Hubs In Shell14.00
Average Links In Shell36.00
Average Links Mediated by Hubs In Shell34.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
3AYM A Sensory Opsins Rhodopsin Todarodes pacificus All-trans-retinal - - 2.8 2011-08-17 10.1016/j.jmb.2011.08.044

A 2D representation of the interactions of RET in 3AYM
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:I41 R:R:K305 5.82 1 Yes Yes 5 7 2 1
R:R:F83 R:R:N87 22.96 1 Yes Yes 7 4 2 2
R:R:F83 R:R:W274 4.01 1 Yes Yes 7 8 2 1
R:R:F83 R:R:K305 4.96 1 Yes Yes 7 7 2 1
R:R:N87 R:R:Y111 16.28 1 Yes Yes 4 5 2 2
R:R:K305 R:R:N87 6.99 1 Yes Yes 7 4 1 2
R:R:N185 R:R:Y111 6.98 1 Yes Yes 4 5 2 2
R:R:K305 R:R:Y111 5.97 1 Yes Yes 7 5 1 2
L:L:?4 R:R:G116 5.68 0 Yes No 0 4 0 1
R:R:F120 R:R:M204 4.98 0 No No 6 5 1 2
R:R:F120 R:R:G208 6.02 0 No No 6 5 1 2
L:L:?4 R:R:F120 10.52 0 Yes No 0 6 0 1
R:R:K305 R:R:N185 8.39 1 Yes Yes 7 4 1 2
R:R:F188 R:R:S187 3.96 0 Yes No 5 3 1 2
R:R:F188 R:R:Y190 6.19 0 Yes Yes 5 5 1 2
R:R:F188 R:R:I201 3.77 0 Yes No 5 5 1 2
R:R:F188 R:R:M204 4.98 0 Yes No 5 5 1 2
L:L:?4 R:R:F188 4.85 0 Yes Yes 0 5 0 1
R:R:F205 R:R:L282 15.83 0 No No 5 6 1 2
L:L:?4 R:R:F205 8.09 0 Yes No 0 5 0 1
R:R:F209 R:R:I213 10.05 0 No No 7 5 1 2
L:L:?4 R:R:F209 14.56 0 Yes No 0 7 0 1
R:R:F270 R:R:W274 19.04 1 Yes Yes 9 8 2 1
R:R:F270 R:R:S307 3.96 1 Yes Yes 9 9 2 2
R:R:A304 R:R:W274 9.08 0 No Yes 7 8 2 1
R:R:S307 R:R:W274 4.94 1 Yes Yes 9 8 2 1
L:L:?4 R:R:W274 23.45 0 Yes Yes 0 8 0 1
L:L:?4 R:R:K305 9.37 0 Yes Yes 0 7 0 1
L:L:?4 R:R:A278 3.14 0 Yes No 0 7 0 1
R:R:G119 R:R:W274 1.41 0 No Yes 7 8 2 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub3.00
Average Interaction Strength9.96
Average Nodes In Shell25.00
Average Hubs In Shell12.00
Average Links In Shell30.00
Average Links Mediated by Hubs In Shell26.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
3AYN A Sensory Opsins Rhodopsin Todarodes pacificus 9-cis-Retinal - - 2.7 2011-08-17 10.1016/j.jmb.2011.08.044

A 2D representation of the interactions of RET in 3AYN
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F83 R:R:N87 22.96 1 Yes Yes 7 4 2 2
R:R:F83 R:R:W274 4.01 1 Yes Yes 7 8 2 1
R:R:F83 R:R:K305 4.96 1 Yes Yes 7 7 2 1
R:R:N87 R:R:Y111 16.28 1 Yes Yes 4 5 2 2
R:R:K305 R:R:N87 6.99 1 Yes Yes 7 4 1 2
R:R:N185 R:R:Y111 6.98 1 Yes Yes 4 5 2 2
R:R:K305 R:R:Y111 7.17 1 Yes Yes 7 5 1 2
L:L:?2 R:R:G116 4.54 1 Yes No 0 4 0 1
R:R:F120 R:R:M204 4.98 0 No No 6 5 1 2
R:R:F120 R:R:G208 6.02 0 No No 6 5 1 2
L:L:?2 R:R:F120 8.09 1 Yes No 0 6 0 1
R:R:E180 R:R:N185 11.83 1 Yes Yes 3 4 2 2
R:R:E180 R:R:S187 10.06 1 Yes Yes 3 3 2 1
R:R:E180 R:R:Y190 6.73 1 Yes Yes 3 5 2 2
R:R:E180 R:R:Y277 10.1 1 Yes Yes 3 6 2 2
R:R:K305 R:R:N185 8.39 1 Yes Yes 7 4 1 2
R:R:F188 R:R:S187 3.96 1 Yes Yes 5 3 1 1
R:R:S187 R:R:Y277 5.09 1 Yes Yes 3 6 1 2
L:L:?2 R:R:S187 6.98 1 Yes Yes 0 3 0 1
R:R:F188 R:R:Y190 8.25 1 Yes Yes 5 5 1 2
R:R:F188 R:R:M204 9.95 1 Yes No 5 5 1 2
L:L:?2 R:R:F188 8.9 1 Yes Yes 0 5 0 1
R:R:Y190 R:R:Y277 9.93 1 Yes Yes 5 6 2 2
R:R:F205 R:R:L282 14.61 0 No No 5 6 1 2
L:L:?2 R:R:F205 11.32 1 Yes No 0 5 0 1
R:R:F209 R:R:I213 10.05 0 No No 7 5 1 2
L:L:?2 R:R:F209 11.32 1 Yes No 0 7 0 1
R:R:F270 R:R:W274 20.04 1 Yes Yes 9 8 2 1
R:R:F270 R:R:S307 3.96 1 Yes Yes 9 9 2 2
R:R:A304 R:R:W274 9.08 0 No Yes 7 8 2 1
R:R:S307 R:R:W274 4.94 1 Yes Yes 9 8 2 1
L:L:?2 R:R:W274 19.67 1 Yes Yes 0 8 0 1
L:L:?2 R:R:K305 7.49 1 Yes Yes 0 7 0 1
R:R:F188 R:R:I201 3.77 1 Yes No 5 5 1 2
L:L:?2 R:R:A278 3.14 1 Yes No 0 7 0 1
R:R:G119 R:R:W274 1.41 0 No Yes 7 8 2 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub4.00
Average Interaction Strength9.05
Average Nodes In Shell26.00
Average Hubs In Shell14.00
Average Links In Shell36.00
Average Links Mediated by Hubs In Shell32.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
3C9L A Sensory Opsins Rhodopsin Bos taurus 11-cis-Retinal - - 2.65 2008-08-05 10.1107/S0907444908017162

A 2D representation of the interactions of RET in 3C9L
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F91 R:R:M44 8.71 1 No Yes 7 7 2 2
R:R:M44 R:R:T94 9.03 1 Yes No 7 7 2 2
R:R:F293 R:R:M44 4.98 1 Yes Yes 5 7 2 2
R:R:K296 R:R:M44 4.32 1 Yes Yes 7 7 1 2
R:R:F91 R:R:K296 8.69 1 No Yes 7 7 2 1
R:R:E113 R:R:T94 12.7 1 Yes No 5 7 1 2
R:R:E113 R:R:S186 5.75 1 Yes No 5 5 1 2
R:R:E113 R:R:K296 6.75 1 Yes Yes 5 7 1 1
L:L:?3 R:R:E113 4.4 1 Yes Yes 0 5 0 1
L:L:?3 R:R:A117 6.28 1 Yes No 0 5 0 1
R:R:T118 R:R:Y178 9.99 0 No Yes 4 3 1 2
L:L:?3 R:R:T118 7.83 1 Yes No 0 4 0 1
R:R:G121 R:R:W265 5.63 0 No Yes 7 8 2 1
R:R:E122 R:R:L125 6.63 1 Yes No 6 7 1 2
R:R:E122 R:R:W126 6.54 1 Yes Yes 6 5 1 2
R:R:C167 R:R:E122 7.6 1 No Yes 5 6 2 1
R:R:E122 R:R:H211 8.62 1 Yes Yes 6 6 1 2
L:L:?3 R:R:E122 9.68 1 Yes Yes 0 6 0 1
R:R:F261 R:R:L125 10.96 0 Yes No 9 7 2 2
R:R:H211 R:R:W126 8.46 1 Yes Yes 6 5 2 2
R:R:C167 R:R:H211 14.74 1 No Yes 5 6 2 2
R:R:I189 R:R:Y178 6.04 1 Yes Yes 4 3 2 2
R:R:E181 R:R:Y191 5.61 1 Yes Yes 4 6 2 2
R:R:E181 R:R:Y268 10.1 1 Yes Yes 4 6 2 1
R:R:E181 R:R:M288 12.18 1 Yes No 4 4 2 2
R:R:F293 R:R:S186 6.61 1 Yes No 5 5 2 2
R:R:K296 R:R:S186 6.12 1 Yes No 7 5 1 2
R:R:I189 R:R:Y191 10.88 1 Yes Yes 4 6 2 2
R:R:F203 R:R:I189 10.05 1 Yes Yes 6 4 2 2
R:R:I189 R:R:M207 4.37 1 Yes Yes 4 5 2 1
R:R:Y191 R:R:Y268 8.94 1 Yes Yes 6 6 2 1
R:R:F203 R:R:M207 4.98 1 Yes Yes 6 5 2 1
R:R:F208 R:R:M207 7.46 0 Yes Yes 5 5 2 1
L:L:?3 R:R:M207 5.63 1 Yes Yes 0 5 0 1
R:R:F212 R:R:L216 4.87 0 Yes No 8 7 1 2
L:L:?3 R:R:F212 5.66 1 Yes Yes 0 8 0 1
R:R:F261 R:R:W265 16.04 0 Yes Yes 9 8 2 1
R:R:C264 R:R:W265 6.53 0 No Yes 8 8 2 1
R:R:A295 R:R:W265 7.78 0 No Yes 8 8 2 1
R:R:S298 R:R:W265 8.65 0 No Yes 9 8 2 1
L:L:?3 R:R:W265 20.42 1 Yes Yes 0 8 0 1
R:R:M288 R:R:Y268 13.17 1 No Yes 4 6 2 1
L:L:?3 R:R:Y268 19.46 1 Yes Yes 0 6 0 1
R:R:F293 R:R:K296 9.93 1 Yes Yes 5 7 2 1
L:L:?3 R:R:K296 8.43 1 Yes Yes 0 7 0 1
R:R:F212 R:R:I213 3.77 0 Yes No 8 4 1 2
R:R:A292 R:R:Y268 2.67 0 No Yes 5 6 2 1
R:R:A269 R:R:F208 1.39 0 No Yes 7 5 2 2
R:R:A269 R:R:F212 1.39 0 No Yes 7 8 2 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub7.00
Average Interaction Strength9.75
Average Nodes In Shell35.00
Average Hubs In Shell19.00
Average Links In Shell49.00
Average Links Mediated by Hubs In Shell49.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
3C9M A Sensory Opsins Rhodopsin Bos taurus 11-cis-Retinal - - 3.4 2008-08-05 10.1107/S0907444908017162

A 2D representation of the interactions of RET in 3C9M
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F91 R:R:M44 6.22 1 Yes Yes 7 7 2 2
R:R:M44 R:R:T94 4.52 1 Yes No 7 7 2 2
R:R:K296 R:R:M44 4.32 1 Yes Yes 7 7 1 2
R:R:F91 R:R:K296 9.93 1 Yes Yes 7 7 2 1
R:R:E113 R:R:T94 11.29 1 Yes No 5 7 1 2
R:R:E113 R:R:G114 4.91 1 Yes No 5 5 1 2
R:R:E113 R:R:K296 5.4 1 Yes Yes 5 7 1 1
L:L:?3 R:R:E113 4.4 1 Yes Yes 0 5 0 1
R:R:G114 R:R:Y178 4.35 0 No Yes 5 3 2 2
L:L:?3 R:R:A117 5.23 1 Yes No 0 5 0 1
R:R:T118 R:R:Y178 9.99 0 No Yes 4 3 1 2
L:L:?3 R:R:T118 6.85 1 Yes No 0 4 0 1
R:R:G121 R:R:W265 5.63 0 No Yes 7 8 2 1
R:R:E181 R:R:Y268 12.35 1 Yes Yes 4 6 2 1
R:R:E181 R:R:M288 8.12 1 Yes No 4 4 2 2
R:R:Y191 R:R:Y268 9.93 1 No Yes 6 6 2 1
R:R:A272 R:R:Y191 8.01 1 No No 5 6 2 2
R:R:F208 R:R:F212 5.36 0 No Yes 5 8 2 1
L:L:?3 R:R:F212 4.04 1 Yes Yes 0 8 0 1
R:R:F261 R:R:W265 23.05 0 Yes Yes 9 8 2 1
R:R:C264 R:R:W265 3.92 0 No Yes 8 8 2 1
R:R:S298 R:R:W265 8.65 0 No Yes 9 8 2 1
L:L:?3 R:R:W265 15.13 1 Yes Yes 0 8 0 1
R:R:A272 R:R:Y268 4 1 No Yes 5 6 2 1
R:R:M288 R:R:Y268 8.38 1 No Yes 4 6 2 1
L:L:?3 R:R:Y268 13.24 1 Yes Yes 0 6 0 1
L:L:?3 R:R:K296 8.43 1 Yes Yes 0 7 0 1
R:R:E113 R:R:F103 3.5 1 Yes Yes 5 8 1 2
R:R:A295 R:R:W265 2.59 0 No Yes 8 8 2 1
R:R:F212 R:R:L266 2.44 0 Yes No 8 6 1 2
R:R:F212 R:R:I213 1.26 0 Yes No 8 4 1 2
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub5.00
Average Interaction Strength8.19
Average Nodes In Shell26.00
Average Hubs In Shell12.00
Average Links In Shell31.00
Average Links Mediated by Hubs In Shell30.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
3OAX A Sensory Opsins Rhodopsin Bos taurus 11-cis-Retinal - - 2.6 2011-01-19 10.1016/j.bpj.2010.08.003

A 2D representation of the interactions of RET in 3OAX
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F91 R:R:M44 8.71 1 Yes Yes 7 7 2 2
R:R:M44 R:R:T94 7.53 1 Yes No 7 7 2 2
R:R:F293 R:R:M44 4.98 1 Yes Yes 5 7 2 2
R:R:K296 R:R:M44 4.32 1 Yes Yes 7 7 1 2
R:R:F91 R:R:K296 7.44 1 Yes Yes 7 7 2 1
R:R:E113 R:R:T94 11.29 1 Yes No 5 7 1 2
R:R:E113 R:R:F103 4.66 1 Yes Yes 5 8 1 2
R:R:E113 R:R:S186 4.31 1 Yes No 5 5 1 2
R:R:E113 R:R:K296 6.75 1 Yes Yes 5 7 1 1
L:L:?2 R:R:E113 5.28 1 Yes Yes 0 5 0 1
L:L:?2 R:R:A117 7.33 1 Yes No 0 5 0 1
R:R:T118 R:R:Y178 6.24 0 No Yes 4 3 1 2
L:L:?2 R:R:T118 9.79 1 Yes No 0 4 0 1
R:R:G121 R:R:W265 5.63 0 No Yes 7 8 2 1
R:R:E122 R:R:L125 6.63 1 Yes No 6 7 1 2
R:R:C167 R:R:E122 6.08 1 No Yes 5 6 2 1
R:R:E122 R:R:H211 7.39 1 Yes Yes 6 6 1 2
L:L:?2 R:R:E122 8.8 1 Yes Yes 0 6 0 1
R:R:F261 R:R:L125 9.74 1 Yes No 9 7 1 2
R:R:F261 R:R:L128 4.87 1 Yes No 9 8 1 2
R:R:C167 R:R:H211 13.27 1 No Yes 5 6 2 2
R:R:E181 R:R:Y191 6.73 1 Yes Yes 4 6 2 2
R:R:E181 R:R:Y268 10.1 1 Yes Yes 4 6 2 1
R:R:E181 R:R:M288 12.18 1 Yes Yes 4 4 2 2
R:R:F293 R:R:S186 6.61 1 Yes No 5 5 2 2
R:R:K296 R:R:S186 4.59 1 Yes No 7 5 1 2
R:R:Y191 R:R:Y268 7.94 1 Yes Yes 6 6 2 1
R:R:F203 R:R:M207 6.22 1 Yes No 6 5 2 1
R:R:F208 R:R:M207 4.98 0 No No 5 5 2 1
L:L:?2 R:R:M207 5.63 1 Yes No 0 5 0 1
R:R:F208 R:R:F212 4.29 0 No Yes 5 8 2 1
L:L:?2 R:R:F212 6.47 1 Yes Yes 0 8 0 1
R:R:F261 R:R:W265 14.03 1 Yes Yes 9 8 1 1
L:L:?2 R:R:F261 4.04 1 Yes Yes 0 9 0 1
R:R:C264 R:R:W265 5.22 0 No Yes 8 8 2 1
R:R:A295 R:R:W265 7.78 0 No Yes 8 8 2 1
R:R:S298 R:R:W265 8.65 0 No Yes 9 8 2 1
L:L:?2 R:R:W265 14.37 1 Yes Yes 0 8 0 1
R:R:M288 R:R:Y268 9.58 1 Yes Yes 4 6 2 1
L:L:?2 R:R:Y268 19.46 1 Yes Yes 0 6 0 1
R:R:F293 R:R:K296 12.41 1 Yes Yes 5 7 2 1
L:L:?2 R:R:K296 7.49 1 Yes Yes 0 7 0 1
R:R:A124 R:R:F261 2.77 0 No Yes 9 9 2 1
R:R:A269 R:R:F212 2.77 0 No Yes 7 8 2 1
R:R:F212 R:R:I213 1.26 0 Yes No 8 4 1 2
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub7.00
Average Interaction Strength8.87
Average Nodes In Shell34.00
Average Hubs In Shell18.00
Average Links In Shell45.00
Average Links Mediated by Hubs In Shell44.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
3PQR A Sensory Opsins Rhodopsin Bos taurus All-trans-retinal - Gt(CT) 2.85 2011-03-09 10.1038/nature09789

A 2D representation of the interactions of RET in 3PQR
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F91 R:R:K296 12.41 0 Yes No 7 7 2 1
R:R:E122 R:R:L125 3.98 1 Yes No 6 7 1 2
R:R:C167 R:R:E122 10.64 1 No Yes 5 6 2 1
R:R:E122 R:R:H211 11.08 1 Yes Yes 6 6 1 2
L:L:?1 R:R:E122 4.4 0 Yes Yes 0 6 0 1
R:R:F261 R:R:L125 3.65 1 Yes No 9 7 2 2
R:R:L125 R:R:W265 18.22 1 No Yes 7 8 2 1
R:R:C167 R:R:M207 6.48 1 No Yes 5 5 2 1
R:R:C167 R:R:H211 4.42 1 No Yes 5 6 2 2
R:R:E181 R:R:Y268 5.61 0 No Yes 4 6 2 1
R:R:Y191 R:R:Y268 5.96 1 Yes Yes 6 6 2 1
R:R:F203 R:R:M207 6.22 1 Yes Yes 6 5 2 1
R:R:H211 R:R:M207 6.57 1 Yes Yes 6 5 2 1
L:L:?1 R:R:M207 11.27 0 Yes Yes 0 5 0 1
R:R:F212 R:R:I213 3.77 0 Yes No 8 4 1 2
R:R:A269 R:R:F212 8.32 0 No Yes 7 8 2 1
R:R:F261 R:R:W265 9.02 1 Yes Yes 9 8 2 1
R:R:C264 R:R:W265 13.06 1 No Yes 8 8 2 1
R:R:A295 R:R:W265 3.89 0 No Yes 8 8 2 1
L:L:?1 R:R:W265 5.3 0 Yes Yes 0 8 0 1
R:R:P291 R:R:Y268 12.52 0 No Yes 6 6 2 1
L:L:?1 R:R:Y268 15.57 0 Yes Yes 0 6 0 1
L:L:?1 R:R:K296 9.37 0 Yes No 0 7 0 1
L:L:?1 R:R:F212 3.24 0 Yes Yes 0 8 0 1
R:R:A292 R:R:Y268 2.67 0 No Yes 5 6 2 1
R:R:F212 R:R:L216 2.44 0 Yes Yes 8 7 1 2
R:R:F261 R:R:L216 2.44 1 Yes Yes 9 7 2 2
L:L:?1 R:R:A117 2.09 0 Yes No 0 5 0 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub5.00
Average Interaction Strength7.32
Average Nodes In Shell23.00
Average Hubs In Shell12.00
Average Links In Shell28.00
Average Links Mediated by Hubs In Shell28.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
3PXO A Sensory Opsins Rhodopsin Bos taurus All-trans-retinal - - 3 2011-03-09 10.1038/nature09789

A 2D representation of the interactions of RET in 3PXO
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F91 R:R:K296 11.17 0 Yes No 7 7 2 1
R:R:F261 R:R:L125 6.09 2 No No 9 7 2 2
R:R:L125 R:R:W265 17.08 2 No Yes 7 8 2 1
R:R:C167 R:R:M207 6.48 2 No Yes 5 5 2 1
R:R:C167 R:R:H211 4.42 2 No Yes 5 6 2 2
R:R:E181 R:R:Y268 6.73 0 No Yes 4 6 2 1
R:R:Y191 R:R:Y268 6.95 3 Yes Yes 6 6 2 1
R:R:F203 R:R:M207 6.22 2 Yes Yes 6 5 2 1
R:R:H211 R:R:M207 9.19 2 Yes Yes 6 5 2 1
L:L:?4 R:R:M207 11.27 0 Yes Yes 0 5 0 1
R:R:F261 R:R:W265 9.02 2 No Yes 9 8 2 1
R:R:C264 R:R:W265 11.75 2 No Yes 8 8 2 1
R:R:A295 R:R:W265 3.89 0 No Yes 8 8 2 1
L:L:?4 R:R:W265 7.56 0 Yes Yes 0 8 0 1
R:R:P291 R:R:Y268 9.74 0 No Yes 6 6 2 1
L:L:?4 R:R:Y268 16.35 0 Yes Yes 0 6 0 1
L:L:?4 R:R:K296 9.37 0 Yes No 0 7 0 1
R:R:A292 R:R:Y268 2.67 0 No Yes 5 6 2 1
L:L:?4 R:R:A117 2.09 0 Yes No 0 5 0 1
R:R:A117 R:R:G90 1.95 0 No No 5 6 1 2
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub3.00
Average Interaction Strength9.33
Average Nodes In Shell19.00
Average Hubs In Shell8.00
Average Links In Shell20.00
Average Links Mediated by Hubs In Shell18.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
4A4M A Sensory Opsins Rhodopsin Bos taurus All-trans-retinal - Gt(CT) 3.3 2012-01-25 10.1073/pnas.1114089108

A 2D representation of the interactions of RET in 4A4M
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F91 R:R:K296 7.44 0 Yes No 7 7 2 1
R:R:L125 R:R:W265 9.11 2 No Yes 7 8 2 1
R:R:C167 R:R:M207 6.48 2 No Yes 5 5 2 1
R:R:C167 R:R:H211 7.37 2 No Yes 5 6 2 2
R:R:Y191 R:R:Y268 5.96 0 Yes Yes 6 6 2 1
R:R:F203 R:R:M207 7.46 2 Yes Yes 6 5 2 1
R:R:H211 R:R:M207 6.57 2 Yes Yes 6 5 2 1
L:L:?2 R:R:M207 6.57 0 Yes Yes 0 5 0 1
R:R:F261 R:R:W265 10.02 0 No Yes 9 8 2 1
R:R:C264 R:R:W265 13.06 0 No Yes 8 8 2 1
R:R:A295 R:R:W265 3.89 0 No Yes 8 8 2 1
L:L:?2 R:R:W265 4.54 0 Yes Yes 0 8 0 1
R:R:P291 R:R:Y268 8.34 0 No Yes 6 6 2 1
R:R:A292 R:R:Y268 4 0 No Yes 5 6 2 1
L:L:?2 R:R:Y268 17.13 0 Yes Yes 0 6 0 1
L:L:?2 R:R:K296 10.3 0 Yes No 0 7 0 1
R:R:E181 R:R:Y268 3.37 0 No Yes 4 6 2 1
StatisticsValue
Average Number Of Links4.00
Average Number Of Links With An Hub3.00
Average Interaction Strength9.63
Average Nodes In Shell17.00
Average Hubs In Shell8.00
Average Links In Shell17.00
Average Links Mediated by Hubs In Shell17.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
4WW3 A Sensory Opsins Rhodopsin Todarodes pacificus All-trans-retinal - - 2.8 2015-06-17 10.1371/journal.pone.0126970

A 2D representation of the interactions of RET in 4WW3
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:I41 R:R:M92 7.29 0 Yes No 5 6 2 2
R:R:I41 R:R:K305 5.82 0 Yes Yes 5 7 2 1
R:R:F83 R:R:N87 16.92 0 No Yes 7 4 2 1
R:R:F83 R:R:K305 4.96 0 No Yes 7 7 2 1
R:R:N87 R:R:Y111 16.28 1 Yes Yes 4 5 1 1
R:R:G115 R:R:N87 5.09 0 No Yes 5 4 2 1
L:L:?1 R:R:N87 4.56 1 Yes Yes 0 4 0 1
R:R:L91 R:R:W101 6.83 1 No Yes 5 8 2 2
R:R:L91 R:R:Y111 8.21 1 No Yes 5 5 2 1
R:R:M92 R:R:Y111 5.99 1 No Yes 6 5 2 1
R:R:M92 R:R:N185 11.22 1 No No 6 4 2 2
R:R:W101 R:R:Y111 7.72 1 Yes Yes 8 5 2 1
R:R:N185 R:R:Y111 5.81 1 No Yes 4 5 2 1
R:R:K305 R:R:Y111 5.97 1 Yes Yes 7 5 1 1
L:L:?1 R:R:Y111 4.67 1 Yes Yes 0 5 0 1
L:L:?1 R:R:G116 5.68 1 Yes No 0 4 0 1
R:R:F120 R:R:M204 4.98 0 Yes No 6 5 1 2
R:R:F120 R:R:G208 6.02 0 Yes No 6 5 1 2
L:L:?1 R:R:F120 13.75 1 Yes Yes 0 6 0 1
R:R:E180 R:R:N185 7.89 1 Yes No 3 4 2 2
R:R:E180 R:R:S187 8.62 1 Yes Yes 3 3 2 1
R:R:E180 R:R:Y190 6.73 1 Yes Yes 3 5 2 2
R:R:E180 R:R:Y277 10.1 1 Yes Yes 3 6 2 2
R:R:F188 R:R:S187 5.28 1 Yes Yes 5 3 1 1
R:R:S187 R:R:Y277 5.09 1 Yes Yes 3 6 1 2
L:L:?1 R:R:S187 7.98 1 Yes Yes 0 3 0 1
R:R:F188 R:R:Y190 10.32 1 Yes Yes 5 5 1 2
R:R:F188 R:R:M204 6.22 1 Yes No 5 5 1 2
L:L:?1 R:R:F188 10.52 1 Yes Yes 0 5 0 1
R:R:Y190 R:R:Y277 5.96 1 Yes Yes 5 6 2 2
R:R:F205 R:R:L282 13.4 0 No No 5 6 1 2
L:L:?1 R:R:F205 12.13 1 Yes No 0 5 0 1
R:R:F209 R:R:I213 11.3 0 No No 7 5 1 2
L:L:?1 R:R:F209 13.75 1 Yes No 0 7 0 1
R:R:F270 R:R:W274 14.03 0 No Yes 9 8 2 1
R:R:A304 R:R:W274 6.48 0 No Yes 7 8 2 1
R:R:S307 R:R:W274 4.94 0 No Yes 9 8 2 1
L:L:?1 R:R:W274 17.4 1 Yes Yes 0 8 0 1
L:L:?1 R:R:K305 7.49 1 Yes Yes 0 7 0 1
R:R:F209 R:R:F210 4.29 0 No No 7 4 1 2
L:L:?1 R:R:A278 3.14 1 Yes No 0 7 0 1
R:R:A167 R:R:F120 2.77 0 No Yes 7 6 2 1
L:L:?1 R:R:G119 1.14 1 Yes No 0 7 0 1
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub7.00
Average Interaction Strength8.52
Average Nodes In Shell32.00
Average Hubs In Shell13.00
Average Links In Shell43.00
Average Links Mediated by Hubs In Shell39.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5DYS A Sensory Opsins Rhodopsin Bos taurus All-trans-retinal - - 2.3 2016-08-10 10.15252/embr.201642671

A 2D representation of the interactions of RET in 5DYS
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F91 R:R:K296 11.17 0 Yes No 7 7 2 1
R:R:L125 R:R:W265 15.94 0 No Yes 7 8 2 1
R:R:C167 R:R:M207 6.48 3 No Yes 5 5 2 1
R:R:C167 R:R:H211 4.42 3 No Yes 5 6 2 2
R:R:E181 R:R:Y268 6.73 0 No Yes 4 6 2 1
R:R:Y191 R:R:Y268 6.95 2 Yes Yes 6 6 2 1
R:R:F203 R:R:M207 7.46 3 Yes Yes 6 5 2 1
R:R:H211 R:R:M207 10.51 3 Yes Yes 6 5 2 1
L:L:?2 R:R:M207 11.27 0 Yes Yes 0 5 0 1
R:R:F261 R:R:W265 8.02 0 No Yes 9 8 2 1
R:R:C264 R:R:W265 13.06 4 No Yes 8 8 2 1
L:L:?2 R:R:W265 6.81 0 Yes Yes 0 8 0 1
R:R:P291 R:R:Y268 12.52 0 No Yes 6 6 2 1
L:L:?2 R:R:Y268 12.46 0 Yes Yes 0 6 0 1
L:L:?2 R:R:K296 9.37 0 Yes No 0 7 0 1
R:R:A295 R:R:W265 3.89 0 No Yes 8 8 2 1
R:R:A292 R:R:Y268 2.67 0 No Yes 5 6 2 1
L:L:?2 R:R:A117 2.09 0 Yes No 0 5 0 1
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub3.00
Average Interaction Strength8.40
Average Nodes In Shell18.00
Average Hubs In Shell8.00
Average Links In Shell18.00
Average Links Mediated by Hubs In Shell18.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5EN0 A Sensory Opsins Rhodopsin Bos taurus All-trans-retinal - Gt(CT) 2.81 2016-08-10 10.15252/embr.201642671

A 2D representation of the interactions of RET in 5EN0
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F91 R:R:K296 11.17 0 Yes No 7 7 2 1
R:R:F261 R:R:L125 4.87 3 Yes No 9 7 2 2
R:R:L125 R:R:W265 17.08 3 No Yes 7 8 2 1
R:R:C167 R:R:M207 6.48 2 No Yes 5 5 2 1
R:R:C167 R:R:H211 4.42 2 No Yes 5 6 2 2
R:R:E181 R:R:Y268 5.61 0 No Yes 4 6 2 1
R:R:Y191 R:R:Y268 5.96 0 Yes Yes 6 6 2 1
R:R:F203 R:R:M207 6.22 2 Yes Yes 6 5 2 1
R:R:H211 R:R:M207 7.88 2 Yes Yes 6 5 2 1
L:L:?2 R:R:M207 11.27 0 Yes Yes 0 5 0 1
R:R:F261 R:R:W265 7.02 3 Yes Yes 9 8 2 1
R:R:C264 R:R:W265 13.06 3 No Yes 8 8 2 1
R:R:A295 R:R:W265 3.89 0 No Yes 8 8 2 1
L:L:?2 R:R:W265 4.54 0 Yes Yes 0 8 0 1
R:R:P291 R:R:Y268 11.13 0 No Yes 6 6 2 1
L:L:?2 R:R:Y268 12.46 0 Yes Yes 0 6 0 1
L:L:?2 R:R:K296 8.43 0 Yes No 0 7 0 1
R:R:A292 R:R:Y268 2.67 0 No Yes 5 6 2 1
StatisticsValue
Average Number Of Links4.00
Average Number Of Links With An Hub3.00
Average Interaction Strength9.18
Average Nodes In Shell17.00
Average Hubs In Shell9.00
Average Links In Shell18.00
Average Links Mediated by Hubs In Shell18.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6FUF A Sensory Opsins Rhodopsin Bos taurus All-trans-retinal - Go/Beta1/Gamma2 3.12 2018-10-03 10.1126/sciadv.aat7052

A 2D representation of the interactions of RET in 6FUF
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F91 R:R:K296 8.69 10 Yes No 7 7 2 1
L:L:?1 R:R:A117 4.19 1 Yes No 0 5 0 1
R:R:A168 R:R:T118 3.36 0 No Yes 7 4 2 1
R:R:T118 R:R:Y178 6.24 1 Yes Yes 4 3 1 2
R:R:I189 R:R:T118 4.56 1 No Yes 4 4 1 1
L:L:?1 R:R:T118 6.85 1 Yes Yes 0 4 0 1
R:R:E122 R:R:L125 3.98 1 Yes Yes 6 7 1 2
R:R:C167 R:R:E122 12.15 1 No Yes 5 6 2 1
R:R:E122 R:R:H211 7.39 1 Yes Yes 6 6 1 2
L:L:?1 R:R:E122 5.28 1 Yes Yes 0 6 0 1
R:R:C167 R:R:M207 6.48 1 No Yes 5 5 2 1
R:R:C167 R:R:H211 5.9 1 No Yes 5 6 2 2
R:R:E181 R:R:Y191 7.86 1 Yes Yes 4 6 2 2
R:R:E181 R:R:Y268 5.61 1 Yes Yes 4 6 2 1
R:R:F203 R:R:I189 6.28 1 Yes No 6 4 2 1
L:L:?1 R:R:I189 4.74 1 Yes No 0 4 0 1
R:R:Y191 R:R:Y268 9.93 1 Yes Yes 6 6 2 1
R:R:F203 R:R:M207 9.95 1 Yes Yes 6 5 2 1
R:R:M207 R:R:Y206 3.59 1 Yes Yes 5 4 1 2
R:R:H211 R:R:Y206 9.8 1 Yes Yes 6 4 2 2
R:R:H211 R:R:M207 9.19 1 Yes Yes 6 5 2 1
L:L:?1 R:R:M207 14.08 1 Yes Yes 0 5 0 1
R:R:P291 R:R:Y268 12.52 0 No Yes 6 6 2 1
L:L:?1 R:R:Y268 4.67 1 Yes Yes 0 6 0 1
L:L:?1 R:R:K296 9.37 1 Yes No 0 7 0 1
R:R:A292 R:R:Y268 2.67 0 No Yes 5 6 2 1
R:R:A295 R:R:Y268 2.67 0 No Yes 8 6 2 1
R:R:A117 R:R:G90 1.95 0 No No 5 6 1 2
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub4.00
Average Interaction Strength7.03
Average Nodes In Shell22.00
Average Hubs In Shell13.00
Average Links In Shell28.00
Average Links Mediated by Hubs In Shell27.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6I9K A Sensory Opsins Rhodopsin Hasarius adansoni 9-cis-Retinal - - 2.15 2019-07-03 10.1073/pnas.1902192116

A 2D representation of the interactions of RET in 6I9K
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F102 R:R:M103 6.22 1 Yes No 4 7 2 2
R:R:F102 R:R:T106 14.27 1 Yes No 4 6 2 2
R:R:F102 R:R:Y126 5.16 1 Yes Yes 4 5 2 1
R:R:M103 R:R:Y126 14.37 1 No Yes 7 5 2 1
R:R:K321 R:R:M103 10.08 1 No No 7 7 1 2
R:R:T106 R:R:Y126 4.99 1 No Yes 6 5 2 1
R:R:M107 R:R:Y126 5.99 1 No Yes 7 5 2 1
R:R:W116 R:R:Y126 5.79 1 Yes Yes 8 5 2 1
R:R:C200 R:R:W116 7.84 1 Yes Yes 9 8 2 2
R:R:S199 R:R:Y126 7.63 0 No Yes 4 5 2 1
R:R:C200 R:R:Y126 4.03 1 Yes Yes 9 5 2 1
R:R:K321 R:R:Y126 5.97 1 No Yes 7 5 1 1
L:L:?1 R:R:Y126 5.45 1 Yes Yes 0 5 0 1
R:R:S131 R:R:Y218 7.63 1 No Yes 4 5 1 1
L:L:?1 R:R:S131 8.98 1 Yes No 0 4 0 1
R:R:G134 R:R:W290 4.22 0 No Yes 6 8 2 1
R:R:S135 R:R:Y218 3.82 0 No Yes 5 5 2 1
R:R:W180 R:R:Y214 5.79 1 Yes Yes 5 7 2 2
R:R:W180 R:R:Y218 10.61 1 Yes Yes 5 5 2 1
R:R:E194 R:R:S199 4.31 1 Yes No 4 4 2 2
R:R:E194 R:R:T201 12.7 1 Yes Yes 4 4 2 1
R:R:E194 R:R:Y204 6.73 1 Yes Yes 4 5 2 2
R:R:E194 R:R:Y293 12.35 1 Yes Yes 4 6 2 1
R:R:T201 R:R:Y204 4.99 1 Yes Yes 4 5 1 2
R:R:T201 R:R:Y293 7.49 1 Yes Yes 4 6 1 1
L:L:?1 R:R:T201 4.89 1 Yes Yes 0 4 0 1
R:R:L296 R:R:Y204 4.69 1 Yes Yes 5 5 2 2
R:R:Y214 R:R:Y218 14.89 1 Yes Yes 7 5 2 1
R:R:V222 R:R:Y218 16.4 1 No Yes 5 5 1 1
L:L:?1 R:R:Y218 6.23 1 Yes Yes 0 5 0 1
L:L:?1 R:R:V222 6.93 1 Yes No 0 5 0 1
R:R:W286 R:R:W290 25.3 0 Yes Yes 9 8 2 1
R:R:A320 R:R:W290 7.78 0 No Yes 7 8 2 1
R:R:S323 R:R:W290 6.18 0 No Yes 9 8 2 1
L:L:?1 R:R:W290 17.4 1 Yes Yes 0 8 0 1
R:R:L296 R:R:Y293 9.38 1 Yes Yes 5 6 2 1
L:L:?1 R:R:Y293 5.45 1 Yes Yes 0 6 0 1
L:L:?1 R:R:K321 7.49 1 Yes No 0 7 0 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub5.00
Average Interaction Strength7.85
Average Nodes In Shell26.00
Average Hubs In Shell15.00
Average Links In Shell38.00
Average Links Mediated by Hubs In Shell37.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6OY9 A Sensory Opsins Rhodopsin Bos taurus All-trans-retinal - Gt/Beta1/Gamma1 3.9 2019-07-24 10.1016/j.molcel.2019.06.007

A 2D representation of the interactions of RET in 6OY9
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:K296 R:R:M86 2.88 0 No Yes 7 7 1 2
R:R:F91 R:R:K296 8.69 9 Yes No 7 7 2 1
R:R:Y191 R:R:Y268 3.97 0 No Yes 6 6 2 1
R:R:F203 R:R:Y206 2.06 2 Yes Yes 6 4 2 2
R:R:F203 R:R:M207 13.68 2 Yes Yes 6 5 2 1
R:R:M207 R:R:Y206 3.59 2 Yes Yes 5 4 1 2
R:R:H211 R:R:M207 13.13 2 Yes Yes 6 5 2 1
L:L:?1 R:R:M207 7.51 0 Yes Yes 0 5 0 1
R:R:A269 R:R:F208 2.77 0 No No 7 5 1 2
R:R:A269 R:R:F212 8.32 0 No No 7 8 1 2
R:R:C264 R:R:W265 6.53 2 Yes No 8 8 2 1
L:L:?1 R:R:W265 11.35 0 Yes No 0 8 0 1
R:R:P291 R:R:Y268 5.56 0 Yes Yes 6 6 2 1
R:R:A295 R:R:Y268 2.67 0 No Yes 8 6 2 1
L:L:?1 R:R:Y268 18.69 0 Yes Yes 0 6 0 1
L:L:?1 R:R:A269 2.09 0 Yes No 0 7 0 1
L:L:?1 R:R:A272 2.09 0 Yes No 0 5 0 1
L:L:?1 R:R:K296 12.18 0 Yes No 0 7 0 1
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub2.00
Average Interaction Strength8.99
Average Nodes In Shell18.00
Average Hubs In Shell10.00
Average Links In Shell18.00
Average Links Mediated by Hubs In Shell16.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6OYA A Sensory Opsins Rhodopsin Bos taurus All-trans-retinal - Gt/Beta1/Gamma1 3.3 2019-07-24 10.1016/j.molcel.2019.06.007

A 2D representation of the interactions of RET in 6OYA
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F91 R:R:M44 4.98 2 Yes Yes 7 7 2 2
R:R:K296 R:R:M44 4.32 2 No Yes 7 7 1 2
R:R:G121 R:R:M86 3.49 0 No No 7 7 2 1
R:R:A299 R:R:M86 4.83 0 No No 9 7 2 1
L:L:?1 R:R:M86 1.88 2 Yes No 0 7 0 1
R:R:F91 R:R:K296 9.93 2 Yes No 7 7 2 1
R:R:A299 R:R:F91 2.77 0 No Yes 9 7 2 2
L:L:?1 R:R:A117 3.14 2 Yes No 0 5 0 1
R:R:T118 R:R:Y178 4.99 2 No Yes 4 3 2 2
R:R:I189 R:R:T118 4.56 2 Yes No 4 4 1 2
R:R:E122 R:R:W126 7.63 2 Yes Yes 6 5 1 2
R:R:C167 R:R:E122 12.15 2 No Yes 5 6 2 1
R:R:E122 R:R:H211 11.08 2 Yes Yes 6 6 1 2
L:L:?1 R:R:E122 3.52 2 Yes Yes 0 6 0 1
R:R:F261 R:R:L125 4.87 2 Yes No 9 7 2 2
R:R:L125 R:R:W265 20.5 2 No Yes 7 8 2 1
R:R:H211 R:R:W126 8.46 2 Yes Yes 6 5 2 2
R:R:C167 R:R:M207 3.24 2 No Yes 5 5 2 1
R:R:C167 R:R:H211 7.37 2 No Yes 5 6 2 2
R:R:P171 R:R:Y178 18.08 2 Yes Yes 5 3 2 2
R:R:I189 R:R:P171 5.08 2 Yes Yes 4 5 1 2
R:R:I189 R:R:Y178 4.84 2 Yes Yes 4 3 1 2
R:R:E181 R:R:Y191 10.1 2 Yes Yes 4 6 2 1
R:R:E181 R:R:Y192 4.49 2 Yes Yes 4 5 2 2
R:R:E181 R:R:Y268 2.24 2 Yes Yes 4 6 2 1
R:R:F203 R:R:I189 5.02 2 Yes Yes 6 4 2 1
R:R:I189 R:R:M207 2.92 2 Yes Yes 4 5 1 1
L:L:?1 R:R:I189 3.79 2 Yes Yes 0 4 0 1
R:R:Y191 R:R:Y192 10.92 2 Yes Yes 6 5 1 2
R:R:Y191 R:R:Y268 3.97 2 Yes Yes 6 6 1 1
R:R:V271 R:R:Y191 5.05 0 No Yes 5 6 2 1
R:R:M288 R:R:Y191 2.39 2 Yes Yes 4 6 2 1
L:L:?1 R:R:Y191 2.34 2 Yes Yes 0 6 0 1
R:R:F203 R:R:Y206 4.13 2 Yes Yes 6 4 2 2
R:R:F203 R:R:M207 12.44 2 Yes Yes 6 5 2 1
R:R:M207 R:R:Y206 3.59 2 Yes Yes 5 4 1 2
R:R:H211 R:R:Y206 4.36 2 Yes Yes 6 4 2 2
R:R:H211 R:R:M207 3.94 2 Yes Yes 6 5 2 1
L:L:?1 R:R:M207 8.45 2 Yes Yes 0 5 0 1
R:R:F261 R:R:W265 9.02 2 Yes Yes 9 8 2 1
R:R:C264 R:R:W265 6.53 2 No Yes 8 8 2 1
R:R:W265 R:R:Y268 3.86 2 Yes Yes 8 6 1 1
L:L:?1 R:R:W265 3.78 2 Yes Yes 0 8 0 1
R:R:P291 R:R:Y268 8.34 0 No Yes 6 6 2 1
R:R:A295 R:R:Y268 5.34 0 No Yes 8 6 2 1
L:L:?1 R:R:Y268 20.24 2 Yes Yes 0 6 0 1
L:L:?1 R:R:K296 10.3 2 Yes No 0 7 0 1
R:R:A272 R:R:Y191 1.33 0 No Yes 5 6 2 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub6.00
Average Interaction Strength6.38
Average Nodes In Shell32.00
Average Hubs In Shell19.00
Average Links In Shell48.00
Average Links Mediated by Hubs In Shell46.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6QNO A Sensory Opsins Rhodopsin Bos taurus All-trans-retinal - Gi1/Beta1/Gamma1 4.38 2019-07-10 10.7554/eLife.46041

A 2D representation of the interactions of RET in 6QNO
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F91 R:R:K296 2.48 0 Yes No 7 7 2 1
L:L:?1 R:R:T118 4.89 0 Yes No 0 4 0 1
R:R:C167 R:R:M207 4.86 2 No Yes 5 5 2 1
R:R:C167 R:R:H211 5.9 2 No Yes 5 6 2 2
R:R:I189 R:R:Y191 4.84 0 No Yes 4 6 2 1
R:R:F203 R:R:I189 3.77 2 Yes No 6 4 2 2
R:R:Y191 R:R:Y192 18.86 0 Yes Yes 6 5 1 2
R:R:V271 R:R:Y191 3.79 0 No Yes 5 6 2 1
L:L:?1 R:R:Y191 5.45 0 Yes Yes 0 6 0 1
R:R:F203 R:R:M207 9.95 2 Yes Yes 6 5 2 1
R:R:H211 R:R:M207 7.88 2 Yes Yes 6 5 2 1
L:L:?1 R:R:M207 10.33 0 Yes Yes 0 5 0 1
R:R:F208 R:R:F212 3.22 13 No Yes 5 8 1 2
R:R:F208 R:R:I213 8.79 13 No No 5 4 1 2
L:L:?1 R:R:F208 3.24 0 Yes No 0 5 0 1
R:R:F212 R:R:I213 3.77 13 Yes No 8 4 2 2
R:R:W265 R:R:Y268 2.89 0 No Yes 8 6 2 1
R:R:P291 R:R:Y268 5.56 0 No Yes 6 6 2 1
R:R:A292 R:R:Y268 4 0 No Yes 5 6 2 1
R:R:A295 R:R:Y268 4 0 No Yes 8 6 2 1
L:L:?1 R:R:Y268 14.79 0 Yes Yes 0 6 0 1
R:R:P291 R:R:V271 3.53 0 No No 6 5 2 2
L:L:?1 R:R:K296 7.49 0 Yes No 0 7 0 1
L:L:?1 R:R:A272 1.05 0 Yes No 0 5 0 1
L:L:?1 R:R:V204 0.99 0 Yes No 0 4 0 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub3.00
Average Interaction Strength6.03
Average Nodes In Shell22.00
Average Hubs In Shell9.00
Average Links In Shell25.00
Average Links Mediated by Hubs In Shell23.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7MT8 A Sensory Opsins Rhodopsin Bos taurus All-trans-retinal - GRK1 5.8 2021-07-07 10.1038/s41586-021-03721-x

A 2D representation of the interactions of RET in 7MT8
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:K296 R:R:M44 4.32 0 No No 7 7 1 2
R:R:F91 R:R:K296 12.41 4 Yes No 7 7 2 1
L:L:?1 R:R:A117 4.19 2 Yes No 0 5 0 1
R:R:L125 R:R:W265 18.22 2 No Yes 7 8 2 1
R:R:E181 R:R:S186 7.19 2 Yes No 4 5 1 2
R:R:E181 R:R:G188 8.19 2 Yes No 4 5 1 2
R:R:E181 R:R:Y268 8.98 2 Yes Yes 4 6 1 1
L:L:?1 R:R:E181 3.52 2 Yes Yes 0 4 0 1
R:R:F203 R:R:I189 3.77 2 Yes Yes 6 4 2 2
R:R:I189 R:R:M207 8.75 2 Yes No 4 5 2 1
R:R:Y191 R:R:Y268 5.96 0 Yes Yes 6 6 2 1
R:R:F203 R:R:M207 11.2 2 Yes No 6 5 2 1
L:L:?1 R:R:M207 6.57 2 Yes No 0 5 0 1
R:R:F212 R:R:I213 3.77 2 Yes No 8 4 1 2
R:R:F212 R:R:L216 6.09 2 Yes No 8 7 1 2
R:R:F212 R:R:F261 4.29 2 Yes Yes 8 9 1 2
R:R:F212 R:R:L266 6.09 2 Yes No 8 6 1 2
R:R:A269 R:R:F212 9.71 0 No Yes 7 8 2 1
L:L:?1 R:R:F212 4.04 2 Yes Yes 0 8 0 1
R:R:F261 R:R:L216 4.87 2 Yes No 9 7 2 2
R:R:F261 R:R:W265 5.01 2 Yes Yes 9 8 2 1
R:R:C264 R:R:W265 18.28 4 No Yes 8 8 2 1
L:L:?1 R:R:W265 6.05 2 Yes Yes 0 8 0 1
R:R:P291 R:R:Y268 8.34 0 No Yes 6 6 2 1
L:L:?1 R:R:Y268 22.58 2 Yes Yes 0 6 0 1
L:L:?1 R:R:K296 9.37 2 Yes No 0 7 0 1
R:R:G121 R:R:W265 2.81 0 No Yes 7 8 2 1
R:R:A295 R:R:Y268 2.67 0 No Yes 8 6 2 1
R:R:A292 R:R:Y268 1.33 0 No Yes 5 6 2 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub4.00
Average Interaction Strength8.05
Average Nodes In Shell26.00
Average Hubs In Shell10.00
Average Links In Shell29.00
Average Links Mediated by Hubs In Shell28.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7MT9 A Sensory Opsins Rhodopsin Bos taurus All-trans-retinal - GRK1 7 2021-07-07 10.1038/s41586-021-03721-x

A 2D representation of the interactions of RET in 7MT9
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:K296 R:R:M44 4.32 1 Yes No 7 7 1 2
R:R:F91 R:R:L47 6.09 1 Yes Yes 7 7 2 2
R:R:K296 R:R:L47 7.05 1 Yes Yes 7 7 1 2
R:R:F91 R:R:K296 9.93 1 Yes Yes 7 7 2 1
R:R:I189 R:R:T118 4.56 1 No No 4 4 1 2
R:R:L125 R:R:W265 9.11 1 Yes No 7 8 2 1
R:R:C167 R:R:M207 3.24 1 No Yes 5 5 2 1
R:R:E181 R:R:G182 3.27 1 Yes No 4 3 1 2
R:R:E181 R:R:S186 7.19 1 Yes No 4 5 1 2
R:R:E181 R:R:G188 8.19 1 Yes No 4 5 1 2
R:R:E181 R:R:Y268 7.86 1 Yes Yes 4 6 1 1
L:L:?1 R:R:E181 3.52 1 Yes Yes 0 4 0 1
R:R:I189 R:R:M207 4.37 1 No Yes 4 5 1 1
L:L:?1 R:R:I189 3.79 1 Yes No 0 4 0 1
R:R:Y191 R:R:Y268 5.96 0 No Yes 6 6 2 1
R:R:F203 R:R:M207 12.44 1 Yes Yes 6 5 2 1
L:L:?1 R:R:M207 10.33 1 Yes Yes 0 5 0 1
R:R:F212 R:R:I213 3.77 1 Yes No 8 4 1 2
R:R:F212 R:R:L216 3.65 1 Yes No 8 7 1 2
R:R:F212 R:R:F261 3.22 1 Yes Yes 8 9 1 2
R:R:F212 R:R:L266 4.87 1 Yes No 8 6 1 2
R:R:A269 R:R:F212 9.71 0 No Yes 7 8 2 1
L:L:?1 R:R:F212 3.24 1 Yes Yes 0 8 0 1
R:R:F261 R:R:L216 4.87 1 Yes No 9 7 2 2
R:R:C264 R:R:W265 18.28 0 No No 8 8 2 1
L:L:?1 R:R:W265 5.3 1 Yes No 0 8 0 1
R:R:P291 R:R:Y268 9.74 0 No Yes 6 6 2 1
L:L:?1 R:R:Y268 23.36 1 Yes Yes 0 6 0 1
L:L:?1 R:R:K296 8.43 1 Yes Yes 0 7 0 1
R:R:A292 R:R:K296 1.61 0 No Yes 5 7 2 1
R:R:M207 R:R:V204 1.52 1 Yes No 5 4 1 2
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub5.00
Average Interaction Strength8.28
Average Nodes In Shell28.00
Average Hubs In Shell11.00
Average Links In Shell31.00
Average Links Mediated by Hubs In Shell29.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7MTA A Sensory Opsins Rhodopsin Bos taurus All-trans-retinal - GRK1 4.1 2021-07-07 10.1038/s41586-021-03721-x

A 2D representation of the interactions of RET in 7MTA
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F91 R:R:L47 14.61 1 Yes Yes 7 7 2 2
R:R:K296 R:R:L47 5.64 1 Yes Yes 7 7 1 2
R:R:F91 R:R:K296 11.17 1 Yes Yes 7 7 2 1
R:R:I189 R:R:T118 4.56 1 No No 4 4 1 2
R:R:G121 R:R:W265 2.81 0 No Yes 7 8 2 1
R:R:L125 R:R:W265 18.22 1 Yes Yes 7 8 2 1
R:R:C167 R:R:M207 3.24 1 No Yes 5 5 2 1
R:R:E181 R:R:Y192 3.37 0 Yes Yes 4 5 2 2
R:R:E181 R:R:Y268 5.61 0 Yes Yes 4 6 2 1
R:R:I189 R:R:M207 2.92 1 No Yes 4 5 1 1
L:L:?1 R:R:I189 4.74 1 Yes No 0 4 0 1
R:R:Y191 R:R:Y192 17.87 1 Yes Yes 6 5 1 2
R:R:Y191 R:R:Y268 5.96 1 Yes Yes 6 6 1 1
R:R:A272 R:R:Y191 5.34 0 No Yes 5 6 2 1
L:L:?1 R:R:Y191 3.11 1 Yes Yes 0 6 0 1
R:R:F203 R:R:M207 12.44 1 Yes Yes 6 5 2 1
L:L:?1 R:R:M207 9.39 1 Yes Yes 0 5 0 1
R:R:F212 R:R:I213 3.77 0 Yes No 8 4 1 2
R:R:F212 R:R:F261 4.29 0 Yes Yes 8 9 1 2
R:R:F212 R:R:L266 3.65 0 Yes No 8 6 1 2
R:R:A269 R:R:F212 8.32 0 No Yes 7 8 2 1
L:L:?1 R:R:F212 4.85 1 Yes Yes 0 8 0 1
R:R:F261 R:R:W265 7.02 0 Yes Yes 9 8 2 1
R:R:C264 R:R:W265 18.28 0 No Yes 8 8 2 1
L:L:?1 R:R:W265 6.81 1 Yes Yes 0 8 0 1
R:R:P291 R:R:Y268 9.74 0 No Yes 6 6 2 1
R:R:A295 R:R:Y268 2.67 0 No Yes 8 6 2 1
L:L:?1 R:R:Y268 23.36 1 Yes Yes 0 6 0 1
L:L:?1 R:R:K296 8.43 1 Yes Yes 0 7 0 1
R:R:A292 R:R:K296 1.61 0 No Yes 5 7 2 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub6.00
Average Interaction Strength8.67
Average Nodes In Shell26.00
Average Hubs In Shell14.00
Average Links In Shell30.00
Average Links Mediated by Hubs In Shell29.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7MTB A Sensory Opsins Rhodopsin Bos taurus All-trans-retinal - GRK1 4 2021-07-07 10.1038/s41586-021-03721-x

A 2D representation of the interactions of RET in 7MTB
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:K296 R:R:M44 4.32 0 No No 7 7 1 2
R:R:F91 R:R:K296 11.17 0 Yes No 7 7 2 1
R:R:I189 R:R:T118 4.56 1 No No 4 4 1 2
R:R:E181 R:R:Y268 5.61 0 Yes Yes 4 6 2 1
R:R:I189 R:R:M207 4.37 1 No No 4 5 1 1
L:L:?1 R:R:I189 8.53 1 Yes No 0 4 0 1
R:R:Y191 R:R:Y268 7.94 0 No Yes 6 6 2 1
R:R:F203 R:R:M207 14.93 1 Yes No 6 5 2 1
L:L:?1 R:R:M207 13.14 1 Yes No 0 5 0 1
R:R:A269 R:R:F212 9.71 0 No No 7 8 2 1
L:L:?1 R:R:F212 4.04 1 Yes No 0 8 0 1
R:R:P291 R:R:Y268 9.74 0 No Yes 6 6 2 1
L:L:?1 R:R:Y268 24.91 1 Yes Yes 0 6 0 1
L:L:?1 R:R:K296 8.43 1 Yes No 0 7 0 1
R:R:F212 R:R:I213 3.77 0 No No 8 4 1 2
L:L:?1 R:R:A117 2.09 1 Yes No 0 5 0 1
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub1.00
Average Interaction Strength10.19
Average Nodes In Shell16.00
Average Hubs In Shell5.00
Average Links In Shell16.00
Average Links Mediated by Hubs In Shell11.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7ZBC A Sensory Opsins Rhodopsin Bos Taurus 11-cis-Retinal - - 1.8 2023-03-29  10.1038/s41586-023-05863-6

A 2D representation of the interactions of RET in 7ZBC
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F91 R:R:K296 9.93 0 Yes Yes 7 7 2 1
R:R:E113 R:R:T94 12.7 1 Yes No 5 7 1 2
R:R:E113 R:R:F103 3.5 1 Yes Yes 5 8 1 2
R:R:E113 R:R:G114 3.27 1 Yes No 5 5 1 2
R:R:E113 R:R:S186 4.31 1 Yes No 5 5 1 2
R:R:E113 R:R:K296 8.1 1 Yes Yes 5 7 1 1
L:L:?1 R:R:E113 5.28 1 Yes Yes 0 5 0 1
R:R:G114 R:R:Y178 4.35 0 No Yes 5 3 2 2
L:L:?1 R:R:A117 6.28 1 Yes No 0 5 0 1
R:R:A168 R:R:T118 3.36 0 No No 7 4 2 1
R:R:T118 R:R:Y178 7.49 0 No Yes 4 3 1 2
L:L:?1 R:R:T118 10.77 1 Yes No 0 4 0 1
R:R:G121 R:R:W265 5.63 0 No Yes 7 8 2 1
R:R:E122 R:R:L125 5.3 1 Yes No 6 7 1 2
R:R:E122 R:R:W126 5.45 1 Yes Yes 6 5 1 2
R:R:C167 R:R:E122 6.08 1 No Yes 5 6 2 1
R:R:E122 R:R:H211 8.62 1 Yes Yes 6 6 1 2
L:L:?1 R:R:E122 10.56 1 Yes Yes 0 6 0 1
R:R:F261 R:R:L125 10.96 1 Yes No 9 7 1 2
R:R:H211 R:R:W126 8.46 1 Yes Yes 6 5 2 2
R:R:F261 R:R:L128 4.87 1 Yes No 9 8 1 2
R:R:C167 R:R:M207 3.24 1 No Yes 5 5 2 1
R:R:C167 R:R:H211 13.27 1 No Yes 5 6 2 2
R:R:I189 R:R:Y178 6.04 1 Yes Yes 4 3 2 2
R:R:E181 R:R:Y191 5.61 1 Yes Yes 4 6 2 2
R:R:E181 R:R:Y268 10.1 1 Yes Yes 4 6 2 1
R:R:E181 R:R:M288 12.18 1 Yes Yes 4 4 2 2
R:R:F293 R:R:S186 5.28 1 Yes No 5 5 2 2
R:R:K296 R:R:S186 4.59 1 Yes No 7 5 1 2
R:R:I189 R:R:Y191 8.46 1 Yes Yes 4 6 2 2
R:R:F203 R:R:I189 6.28 1 Yes Yes 6 4 2 2
R:R:I189 R:R:M207 5.83 1 Yes Yes 4 5 2 1
R:R:Y191 R:R:Y268 7.94 1 Yes Yes 6 6 2 1
R:R:F203 R:R:M207 4.98 1 Yes Yes 6 5 2 1
L:L:?1 R:R:M207 4.69 1 Yes Yes 0 5 0 1
R:R:F208 R:R:F212 3.22 0 No Yes 5 8 2 1
R:R:F212 R:R:L216 4.87 0 Yes No 8 7 1 2
L:L:?1 R:R:F212 5.66 1 Yes Yes 0 8 0 1
R:R:F261 R:R:W265 14.03 1 Yes Yes 9 8 1 1
L:L:?1 R:R:F261 3.24 1 Yes Yes 0 9 0 1
R:R:C264 R:R:W265 9.14 0 No Yes 8 8 2 1
R:R:A295 R:R:W265 7.78 0 No Yes 8 8 2 1
R:R:S298 R:R:W265 8.65 0 No Yes 9 8 2 1
L:L:?1 R:R:W265 18.15 1 Yes Yes 0 8 0 1
R:R:M288 R:R:Y268 8.38 1 Yes Yes 4 6 2 1
L:L:?1 R:R:Y268 17.13 1 Yes Yes 0 6 0 1
R:R:F293 R:R:K296 8.69 1 Yes Yes 5 7 2 1
L:L:?1 R:R:K296 8.43 1 Yes Yes 0 7 0 1
R:R:A124 R:R:F261 2.77 0 No Yes 9 9 2 1
R:R:A269 R:R:F212 2.77 0 No Yes 7 8 2 1
R:R:F212 R:R:I213 1.26 0 Yes No 8 4 1 2
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub8.00
Average Interaction Strength9.02
Average Nodes In Shell38.00
Average Hubs In Shell20.00
Average Links In Shell51.00
Average Links Mediated by Hubs In Shell50.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7ZBE A Sensory Opsins Rhodopsin Bos Taurus 11-cis-Retinal - - 1.8 2023-03-29  10.1038/s41586-023-05863-6

A 2D representation of the interactions of RET in 7ZBE
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F91 R:R:K296 8.69 0 Yes Yes 7 7 2 1
R:R:E113 R:R:T94 12.7 1 Yes No 5 7 1 2
R:R:E113 R:R:G114 3.27 1 Yes No 5 5 1 2
R:R:E113 R:R:S186 4.31 1 Yes No 5 5 1 2
R:R:E113 R:R:K296 8.1 1 Yes Yes 5 7 1 1
L:L:?1 R:R:E113 5.28 1 Yes Yes 0 5 0 1
R:R:G114 R:R:Y178 4.35 0 No Yes 5 3 2 2
L:L:?1 R:R:A117 6.28 1 Yes No 0 5 0 1
R:R:A168 R:R:T118 3.36 0 No No 7 4 2 1
R:R:T118 R:R:Y178 6.24 0 No Yes 4 3 1 2
L:L:?1 R:R:T118 10.77 1 Yes No 0 4 0 1
R:R:G121 R:R:W265 5.63 0 No Yes 7 8 2 1
R:R:E122 R:R:L125 5.3 1 Yes No 6 7 1 2
R:R:E122 R:R:W126 6.54 1 Yes Yes 6 5 1 2
R:R:C167 R:R:E122 7.6 1 No Yes 5 6 2 1
R:R:E122 R:R:H211 8.62 1 Yes Yes 6 6 1 2
L:L:?1 R:R:E122 7.92 1 Yes Yes 0 6 0 1
R:R:F261 R:R:L125 8.53 1 Yes No 9 7 1 2
R:R:H211 R:R:W126 8.46 1 Yes Yes 6 5 2 2
R:R:F261 R:R:L128 4.87 1 Yes No 9 8 1 2
R:R:C167 R:R:M207 3.24 1 No No 5 5 2 1
R:R:C167 R:R:H211 13.27 1 No Yes 5 6 2 2
R:R:I189 R:R:Y178 3.63 1 Yes Yes 4 3 2 2
R:R:E181 R:R:Y191 4.49 1 Yes Yes 4 6 2 2
R:R:E181 R:R:Y268 10.1 1 Yes Yes 4 6 2 1
R:R:E181 R:R:M288 9.47 1 Yes Yes 4 4 2 2
R:R:F293 R:R:S186 5.28 1 Yes No 5 5 2 2
R:R:K296 R:R:S186 4.59 1 Yes No 7 5 1 2
R:R:I189 R:R:Y191 8.46 1 Yes Yes 4 6 2 2
R:R:I189 R:R:M207 5.83 1 Yes No 4 5 2 1
R:R:Y191 R:R:Y268 7.94 1 Yes Yes 6 6 2 1
L:L:?1 R:R:M207 4.69 1 Yes No 0 5 0 1
R:R:F208 R:R:F212 3.22 0 No Yes 5 8 2 1
R:R:F212 R:R:L216 4.87 0 Yes No 8 7 1 2
L:L:?1 R:R:F212 5.66 1 Yes Yes 0 8 0 1
R:R:F261 R:R:W265 14.03 1 Yes Yes 9 8 1 1
L:L:?1 R:R:F261 3.24 1 Yes Yes 0 9 0 1
R:R:C264 R:R:W265 10.45 0 No Yes 8 8 2 1
R:R:A295 R:R:W265 6.48 0 No Yes 8 8 2 1
R:R:S298 R:R:W265 8.65 0 No Yes 9 8 2 1
L:L:?1 R:R:W265 18.91 1 Yes Yes 0 8 0 1
R:R:M288 R:R:Y268 8.38 1 Yes Yes 4 6 2 1
L:L:?1 R:R:Y268 17.13 1 Yes Yes 0 6 0 1
R:R:F293 R:R:K296 8.69 1 Yes Yes 5 7 2 1
L:L:?1 R:R:K296 7.49 1 Yes Yes 0 7 0 1
R:R:A124 R:R:F261 2.77 0 No Yes 9 9 2 1
R:R:A269 R:R:F212 2.77 0 No Yes 7 8 2 1
R:R:F212 R:R:I213 1.26 0 Yes No 8 4 1 2
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub7.00
Average Interaction Strength8.74
Average Nodes In Shell36.00
Average Hubs In Shell17.00
Average Links In Shell48.00
Average Links Mediated by Hubs In Shell46.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8A6C A Sensory Opsins Rhodopsin Bos Taurus All-trans-retinal - - 1.8 2023-03-29  10.1038/s41586-023-05863-6

A 2D representation of the interactions of RET in 8A6C
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F91 R:R:K296 4.96 0 No Yes 7 7 2 1
R:R:E113 R:R:T94 11.29 1 Yes No 5 7 1 2
R:R:E113 R:R:F103 3.5 1 Yes Yes 5 8 1 2
R:R:C187 R:R:F103 6.98 1 Yes Yes 9 8 2 2
R:R:E113 R:R:G114 3.27 1 Yes No 5 5 1 2
R:R:E113 R:R:S186 4.31 1 Yes Yes 5 5 1 2
R:R:C187 R:R:E113 3.04 1 Yes Yes 9 5 2 1
R:R:E113 R:R:K296 6.75 1 Yes Yes 5 7 1 1
L:L:?1 R:R:E113 4.4 1 Yes Yes 0 5 0 1
R:R:G114 R:R:Y178 4.35 0 No Yes 5 3 2 2
L:L:?1 R:R:A117 3.14 1 Yes No 0 5 0 1
R:R:A168 R:R:T118 3.36 0 No No 7 4 2 1
R:R:T118 R:R:Y178 7.49 0 No Yes 4 3 1 2
L:L:?1 R:R:T118 8.81 1 Yes No 0 4 0 1
R:R:E122 R:R:L125 6.63 1 Yes No 6 7 1 2
R:R:E122 R:R:W126 7.63 1 Yes Yes 6 5 1 2
R:R:C167 R:R:E122 6.08 1 No Yes 5 6 2 1
R:R:E122 R:R:H211 9.85 1 Yes Yes 6 6 1 2
L:L:?1 R:R:E122 8.8 1 Yes Yes 0 6 0 1
R:R:F261 R:R:L125 9.74 1 Yes No 9 7 1 2
R:R:H211 R:R:W126 9.52 1 Yes Yes 6 5 2 2
R:R:F261 R:R:L128 4.87 1 Yes No 9 8 1 2
R:R:C167 R:R:H211 11.79 1 No Yes 5 6 2 2
R:R:E181 R:R:Y191 4.49 1 Yes Yes 4 6 2 2
R:R:E181 R:R:Y268 6.73 1 Yes Yes 4 6 2 1
R:R:E181 R:R:M288 9.47 1 Yes Yes 4 4 2 2
R:R:F293 R:R:S186 6.61 1 Yes Yes 5 5 2 2
R:R:K296 R:R:S186 6.12 1 Yes Yes 7 5 1 2
R:R:Y191 R:R:Y268 7.94 1 Yes Yes 6 6 2 1
R:R:F208 R:R:F212 3.22 0 No Yes 5 8 2 1
R:R:F212 R:R:L216 4.87 0 Yes No 8 7 1 2
L:L:?1 R:R:F212 4.85 1 Yes Yes 0 8 0 1
R:R:F261 R:R:W265 15.03 1 Yes Yes 9 8 1 1
R:R:F261 R:R:Y301 3.09 1 Yes No 9 5 1 2
L:L:?1 R:R:F261 3.24 1 Yes Yes 0 9 0 1
R:R:C264 R:R:W265 9.14 0 No Yes 8 8 2 1
R:R:A295 R:R:W265 3.89 0 No Yes 8 8 2 1
R:R:S298 R:R:W265 4.94 0 No Yes 9 8 2 1
L:L:?1 R:R:W265 18.91 1 Yes Yes 0 8 0 1
R:R:M288 R:R:Y268 5.99 1 Yes Yes 4 6 2 1
L:L:?1 R:R:Y268 10.9 1 Yes Yes 0 6 0 1
R:R:F293 R:R:K296 11.17 1 Yes Yes 5 7 2 1
L:L:?1 R:R:K296 8.43 1 Yes Yes 0 7 0 1
R:R:E113 R:R:T93 2.82 1 Yes No 5 5 1 2
R:R:G121 R:R:W265 2.81 0 No Yes 7 8 2 1
R:R:F212 R:R:L266 2.44 0 Yes No 8 6 1 2
R:R:A269 R:R:F212 1.39 0 No Yes 7 8 2 1
R:R:F212 R:R:I213 1.26 0 Yes No 8 4 1 2
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub7.00
Average Interaction Strength7.94
Average Nodes In Shell38.00
Average Hubs In Shell18.00
Average Links In Shell48.00
Average Links Mediated by Hubs In Shell47.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8A6D A Sensory Opsins Rhodopsin Bos Taurus All-trans-retinal - - 1.8 2023-03-29  10.1038/s41586-023-05863-6

A 2D representation of the interactions of RET in 8A6D
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F91 R:R:M44 8.71 1 Yes Yes 7 7 2 2
R:R:M44 R:R:T94 10.54 1 Yes No 7 7 2 2
R:R:F293 R:R:M44 4.98 1 Yes Yes 5 7 2 2
R:R:K296 R:R:M44 4.32 1 Yes Yes 7 7 1 2
R:R:F91 R:R:K296 8.69 1 Yes Yes 7 7 2 1
R:R:E113 R:R:T94 12.7 1 Yes No 5 7 1 2
R:R:E113 R:R:G114 3.27 1 Yes No 5 5 1 2
R:R:E113 R:R:S186 5.75 1 Yes No 5 5 1 2
R:R:E113 R:R:K296 8.1 1 Yes Yes 5 7 1 1
L:L:?1 R:R:E113 5.28 1 Yes Yes 0 5 0 1
R:R:G114 R:R:Y178 4.35 0 No Yes 5 3 2 2
R:R:A168 R:R:T118 3.36 0 No No 7 4 2 1
R:R:T118 R:R:Y178 6.24 0 No Yes 4 3 1 2
L:L:?1 R:R:T118 11.75 1 Yes No 0 4 0 1
R:R:G121 R:R:W265 5.63 0 No Yes 7 8 2 1
R:R:E122 R:R:L125 3.98 1 Yes No 6 7 1 2
R:R:E122 R:R:W126 6.54 1 Yes Yes 6 5 1 2
R:R:C167 R:R:E122 7.6 1 No Yes 5 6 2 1
R:R:E122 R:R:H211 9.85 1 Yes Yes 6 6 1 2
L:L:?1 R:R:E122 9.68 1 Yes Yes 0 6 0 1
R:R:F261 R:R:L125 10.96 1 Yes No 9 7 1 2
R:R:H211 R:R:W126 7.41 1 Yes Yes 6 5 2 2
R:R:F261 R:R:L128 4.87 1 Yes No 9 8 1 2
R:R:C167 R:R:H211 13.27 1 No Yes 5 6 2 2
R:R:E181 R:R:Y191 5.61 1 Yes Yes 4 6 2 2
R:R:E181 R:R:Y268 7.86 1 Yes Yes 4 6 2 1
R:R:E181 R:R:M288 9.47 1 Yes Yes 4 4 2 2
R:R:F293 R:R:S186 6.61 1 Yes No 5 5 2 2
R:R:K296 R:R:S186 6.12 1 Yes No 7 5 1 2
R:R:Y191 R:R:Y268 6.95 1 Yes Yes 6 6 2 1
R:R:F212 R:R:L216 6.09 0 Yes No 8 7 1 2
L:L:?1 R:R:F212 5.66 1 Yes Yes 0 8 0 1
R:R:F261 R:R:W265 14.03 1 Yes Yes 9 8 1 1
L:L:?1 R:R:F261 3.24 1 Yes Yes 0 9 0 1
R:R:C264 R:R:W265 9.14 1 No Yes 8 8 2 1
R:R:C264 R:R:S298 3.44 1 No No 8 9 2 2
R:R:A295 R:R:W265 3.89 0 No Yes 8 8 2 1
R:R:S298 R:R:W265 8.65 1 No Yes 9 8 2 1
L:L:?1 R:R:W265 17.4 1 Yes Yes 0 8 0 1
R:R:M288 R:R:Y268 5.99 1 Yes Yes 4 6 2 1
L:L:?1 R:R:Y268 13.24 1 Yes Yes 0 6 0 1
R:R:F293 R:R:K296 7.44 1 Yes Yes 5 7 2 1
L:L:?1 R:R:K296 8.43 1 Yes Yes 0 7 0 1
L:L:?1 R:R:A117 3.14 1 Yes No 0 5 0 1
R:R:A124 R:R:F261 2.77 0 No Yes 9 9 2 1
R:R:A292 R:R:Y268 2.67 0 No Yes 5 6 2 1
R:R:A269 R:R:F212 1.39 0 No Yes 7 8 2 1
R:R:F212 R:R:I213 1.26 0 Yes No 8 4 1 2
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub7.00
Average Interaction Strength8.65
Average Nodes In Shell35.00
Average Hubs In Shell17.00
Average Links In Shell48.00
Average Links Mediated by Hubs In Shell46.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8A6E A Sensory Opsins Rhodopsin Bos Taurus All-trans-retinal - - 1.8 2023-03-29  10.1038/s41586-023-05863-6

A 2D representation of the interactions of RET in 8A6E
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F91 R:R:M44 8.71 1 No Yes 7 7 2 2
R:R:M44 R:R:T94 10.54 1 Yes No 7 7 2 2
R:R:F293 R:R:M44 4.98 1 Yes Yes 5 7 2 2
R:R:K296 R:R:M44 4.32 1 Yes Yes 7 7 1 2
R:R:F91 R:R:K296 6.2 1 No Yes 7 7 2 1
R:R:E113 R:R:T93 4.23 1 Yes No 5 5 1 2
R:R:E113 R:R:T94 14.11 1 Yes No 5 7 1 2
R:R:K296 R:R:T94 4.5 1 Yes No 7 7 1 2
R:R:E113 R:R:S186 4.31 1 Yes No 5 5 1 2
R:R:E113 R:R:K296 8.1 1 Yes Yes 5 7 1 1
L:L:?1 R:R:E113 5.28 1 Yes Yes 0 5 0 1
R:R:T118 R:R:Y178 9.99 0 No Yes 4 3 1 2
L:L:?1 R:R:T118 9.79 1 Yes No 0 4 0 1
R:R:G121 R:R:W265 5.63 0 No Yes 7 8 2 1
R:R:E122 R:R:L125 3.98 1 Yes No 6 7 1 2
R:R:E122 R:R:W126 4.36 1 Yes Yes 6 5 1 2
R:R:C167 R:R:E122 7.6 1 No Yes 5 6 2 1
R:R:E122 R:R:H211 7.39 1 Yes Yes 6 6 1 2
L:L:?1 R:R:E122 9.68 1 Yes Yes 0 6 0 1
R:R:F261 R:R:L125 13.4 1 Yes No 9 7 1 2
R:R:H211 R:R:W126 7.41 1 Yes Yes 6 5 2 2
R:R:F261 R:R:L128 4.87 1 Yes No 9 8 1 2
R:R:C167 R:R:H211 13.27 1 No Yes 5 6 2 2
R:R:E181 R:R:Y191 4.49 1 Yes Yes 4 6 2 2
R:R:E181 R:R:Y268 10.1 1 Yes Yes 4 6 2 1
R:R:E181 R:R:M288 8.12 1 Yes No 4 4 2 2
R:R:F293 R:R:S186 6.61 1 Yes No 5 5 2 2
R:R:K296 R:R:S186 6.12 1 Yes No 7 5 1 2
R:R:Y191 R:R:Y268 6.95 1 Yes Yes 6 6 2 1
R:R:F208 R:R:F212 5.36 0 Yes Yes 5 8 2 1
R:R:F212 R:R:L216 6.09 0 Yes No 8 7 1 2
L:L:?1 R:R:F212 5.66 1 Yes Yes 0 8 0 1
R:R:F261 R:R:W265 12.03 1 Yes Yes 9 8 1 1
L:L:?1 R:R:F261 4.04 1 Yes Yes 0 9 0 1
R:R:C264 R:R:W265 7.84 0 No Yes 8 8 2 1
R:R:A295 R:R:W265 6.48 0 No Yes 8 8 2 1
R:R:S298 R:R:W265 7.41 0 No Yes 9 8 2 1
L:L:?1 R:R:W265 21.94 1 Yes Yes 0 8 0 1
R:R:M288 R:R:Y268 7.18 1 No Yes 4 6 2 1
L:L:?1 R:R:Y268 13.24 1 Yes Yes 0 6 0 1
R:R:F293 R:R:K296 11.17 1 Yes Yes 5 7 2 1
L:L:?1 R:R:K296 9.37 1 Yes Yes 0 7 0 1
R:R:A168 R:R:T118 3.36 0 No No 7 4 2 1
L:L:?1 R:R:A117 3.14 1 Yes No 0 5 0 1
R:R:P291 R:R:Y268 2.78 0 No Yes 6 6 2 1
R:R:A292 R:R:Y268 2.67 0 No Yes 5 6 2 1
R:R:F212 R:R:I213 1.26 0 Yes No 8 4 1 2
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub7.00
Average Interaction Strength9.13
Average Nodes In Shell35.00
Average Hubs In Shell16.00
Average Links In Shell47.00
Average Links Mediated by Hubs In Shell46.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8FCZ A Sensory Opsins Rhodopsin Bos Taurus 11-cis-Retinal - - 3.7 2023-08-30 10.1038/s41467-023-40911-9

A 2D representation of the interactions of RET in 8FCZ
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M44 R:R:T94 9.03 0 Yes No 7 7 2 2
R:R:K296 R:R:M44 7.2 1 Yes Yes 7 7 1 2
R:R:E113 R:R:T94 12.7 1 Yes No 5 7 1 2
R:R:E113 R:R:K296 9.45 1 Yes Yes 5 7 1 1
L:L:?1 R:R:E113 6.16 1 Yes Yes 0 5 0 1
L:L:?1 R:R:A117 4.19 1 Yes No 0 5 0 1
R:R:T118 R:R:Y178 8.74 0 No Yes 4 3 1 2
L:L:?1 R:R:T118 7.83 1 Yes No 0 4 0 1
R:R:G121 R:R:W265 5.63 0 No Yes 7 8 2 1
R:R:E122 R:R:L125 3.98 1 Yes No 6 7 1 2
R:R:E122 R:R:W126 5.45 1 Yes Yes 6 5 1 2
R:R:C167 R:R:E122 10.64 1 No Yes 5 6 2 1
R:R:E122 R:R:H211 7.39 1 Yes Yes 6 6 1 2
L:L:?1 R:R:E122 7.92 1 Yes Yes 0 6 0 1
R:R:F261 R:R:L125 10.96 0 Yes No 9 7 2 2
R:R:C167 R:R:H211 16.22 1 No Yes 5 6 2 2
R:R:I189 R:R:Y178 6.04 1 Yes Yes 4 3 2 2
R:R:E181 R:R:Y191 5.61 1 Yes Yes 4 6 2 2
R:R:E181 R:R:Y268 10.1 1 Yes Yes 4 6 2 1
R:R:E181 R:R:M288 4.06 1 Yes Yes 4 4 2 2
R:R:I189 R:R:Y191 8.46 1 Yes Yes 4 6 2 2
R:R:F203 R:R:I189 7.54 1 Yes Yes 6 4 2 2
R:R:I189 R:R:M207 5.83 1 Yes No 4 5 2 1
R:R:Y191 R:R:Y268 10.92 1 Yes Yes 6 6 2 1
R:R:F203 R:R:M207 4.98 1 Yes No 6 5 2 1
L:L:?1 R:R:M207 6.57 1 Yes No 0 5 0 1
R:R:F212 R:R:I213 7.54 0 No No 8 4 1 2
R:R:F212 R:R:L216 4.87 0 No No 8 7 1 2
L:L:?1 R:R:F212 6.47 1 Yes No 0 8 0 1
R:R:F261 R:R:W265 14.03 0 Yes Yes 9 8 2 1
R:R:C264 R:R:W265 10.45 0 No Yes 8 8 2 1
R:R:A295 R:R:W265 7.78 0 No Yes 8 8 2 1
R:R:S298 R:R:W265 8.65 0 No Yes 9 8 2 1
L:L:?1 R:R:W265 15.89 1 Yes Yes 0 8 0 1
R:R:M288 R:R:Y268 5.99 1 Yes Yes 4 6 2 1
L:L:?1 R:R:Y268 17.91 1 Yes Yes 0 6 0 1
R:R:F293 R:R:K296 9.93 0 Yes Yes 5 7 2 1
L:L:?1 R:R:K296 7.49 1 Yes Yes 0 7 0 1
R:R:A168 R:R:T118 3.36 0 No No 7 4 2 1
L:L:?1 R:R:A269 3.14 1 Yes No 0 7 0 1
R:R:E113 R:R:T93 2.82 1 Yes Yes 5 5 1 2
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub5.00
Average Interaction Strength8.36
Average Nodes In Shell33.00
Average Hubs In Shell18.00
Average Links In Shell41.00
Average Links Mediated by Hubs In Shell38.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8FCZ_poly A Sensory Opsins Rhodopsin Bos Taurus 11-cis-Retinal - - 3.7 2023-08-30 10.1038/s41467-023-40911-9

A 2D representation of the interactions of RET in 8FCZ_poly
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F91 R:R:M44 8.71 2 Yes Yes 7 7 2 2
R:R:M44 R:R:T94 9.03 2 Yes No 7 7 2 2
R:R:K296 R:R:M44 7.2 2 Yes Yes 7 7 1 2
R:R:F91 R:R:K296 3.72 2 Yes Yes 7 7 2 1
R:R:E113 R:R:T94 12.7 2 Yes No 5 7 1 2
R:R:E113 R:R:F103 3.5 2 Yes Yes 5 8 1 2
R:R:C187 R:R:F103 6.98 2 Yes Yes 9 8 2 2
R:R:E113 R:R:G114 3.27 2 Yes No 5 5 1 2
R:R:C187 R:R:E113 3.04 2 Yes Yes 9 5 2 1
R:R:E113 R:R:K296 9.45 2 Yes Yes 5 7 1 1
L:L:?1 R:R:E113 6.16 2 Yes Yes 0 5 0 1
R:R:G114 R:R:Y178 5.79 0 No Yes 5 3 2 2
L:L:?1 R:R:A117 4.19 2 Yes No 0 5 0 1
R:R:A168 R:R:T118 3.36 0 No No 7 4 2 1
R:R:T118 R:R:Y178 8.74 0 No Yes 4 3 1 2
L:L:?1 R:R:T118 7.83 2 Yes No 0 4 0 1
R:R:G121 R:R:W265 5.63 0 No Yes 7 8 2 1
R:R:E122 R:R:L125 3.98 2 Yes No 6 7 1 2
R:R:E122 R:R:W126 5.45 2 Yes Yes 6 5 1 2
R:R:C167 R:R:E122 10.64 2 No Yes 5 6 2 1
R:R:E122 R:R:H211 7.39 2 Yes Yes 6 6 1 2
L:L:?1 R:R:E122 7.92 2 Yes Yes 0 6 0 1
R:R:F261 R:R:L125 10.96 0 Yes No 9 7 2 2
R:R:H211 R:R:W126 3.17 2 Yes Yes 6 5 2 2
R:R:C167 R:R:H211 16.22 2 No Yes 5 6 2 2
R:R:I189 R:R:Y178 6.04 2 Yes Yes 4 3 2 2
R:R:E181 R:R:Y191 5.61 2 Yes Yes 4 6 2 2
R:R:E181 R:R:Y268 10.1 2 Yes Yes 4 6 2 1
R:R:E181 R:R:M288 4.06 2 Yes Yes 4 4 2 2
R:R:F293 R:R:S186 6.61 2 Yes No 5 5 2 1
R:R:K296 R:R:S186 3.06 2 Yes No 7 5 1 1
L:L:?1 R:R:S186 2.99 2 Yes No 0 5 0 1
R:R:I189 R:R:Y191 8.46 2 Yes Yes 4 6 2 2
R:R:F203 R:R:I189 7.54 2 Yes Yes 6 4 2 2
R:R:I189 R:R:M207 5.83 2 Yes Yes 4 5 2 1
R:R:M207 R:R:Y191 3.59 2 Yes Yes 5 6 1 2
R:R:Y191 R:R:Y268 10.92 2 Yes Yes 6 6 2 1
R:R:F203 R:R:M207 4.98 2 Yes Yes 6 5 2 1
L:L:?1 R:R:M207 6.57 2 Yes Yes 0 5 0 1
R:R:F212 R:R:I213 7.54 0 No No 8 4 1 2
R:R:F212 R:R:L216 4.87 0 No No 8 7 1 2
L:L:?1 R:R:F212 6.47 2 Yes No 0 8 0 1
R:R:F261 R:R:W265 14.03 0 Yes Yes 9 8 2 1
R:R:C264 R:R:W265 10.45 0 No Yes 8 8 2 1
R:R:A295 R:R:W265 7.78 0 No Yes 8 8 2 1
R:R:S298 R:R:W265 8.65 0 No Yes 9 8 2 1
L:L:?1 R:R:W265 15.89 2 Yes Yes 0 8 0 1
R:R:M288 R:R:Y268 5.99 2 Yes Yes 4 6 2 1
L:L:?1 R:R:Y268 17.91 2 Yes Yes 0 6 0 1
L:L:?1 R:R:A269 3.14 2 Yes No 0 7 0 1
R:R:F293 R:R:K296 9.93 2 Yes Yes 5 7 2 1
L:L:?1 R:R:K296 7.49 2 Yes Yes 0 7 0 1
R:R:E113 R:R:T93 2.82 2 Yes Yes 5 5 1 2
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub6.00
Average Interaction Strength7.87
Average Nodes In Shell38.00
Average Hubs In Shell22.00
Average Links In Shell53.00
Average Links Mediated by Hubs In Shell50.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of RET in 8FCZ_poly
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:F91 S:S:M44 8.71 1 Yes Yes 7 7 2 2
S:S:M44 S:S:T94 9.03 1 Yes No 7 7 2 2
S:S:K296 S:S:M44 7.2 1 Yes Yes 7 7 1 2
S:S:F91 S:S:K296 3.72 1 Yes Yes 7 7 2 1
S:S:E113 S:S:T94 12.7 1 Yes No 5 7 1 2
S:S:E113 S:S:F103 3.5 1 Yes Yes 5 8 1 2
S:S:C187 S:S:F103 6.98 1 Yes Yes 9 8 2 2
S:S:E113 S:S:G114 3.27 1 Yes No 5 5 1 2
S:S:C187 S:S:E113 3.04 1 Yes Yes 9 5 2 1
S:S:E113 S:S:K296 9.45 1 Yes Yes 5 7 1 1
M:M:?1 S:S:E113 6.16 1 Yes Yes 0 5 0 1
S:S:G114 S:S:Y178 5.79 0 No Yes 5 3 2 2
M:M:?1 S:S:A117 5.23 1 Yes No 0 5 0 1
S:S:A168 S:S:T118 3.36 0 No No 7 4 2 1
S:S:T118 S:S:Y178 8.74 0 No Yes 4 3 1 2
M:M:?1 S:S:T118 8.81 1 Yes No 0 4 0 1
S:S:G121 S:S:W265 5.63 0 No Yes 7 8 2 1
S:S:E122 S:S:L125 3.98 1 Yes Yes 6 7 1 2
S:S:E122 S:S:W126 5.45 1 Yes Yes 6 5 1 2
S:S:C167 S:S:E122 10.64 1 No Yes 5 6 2 1
S:S:E122 S:S:H211 8.62 1 Yes Yes 6 6 1 2
M:M:?1 S:S:E122 7.92 1 Yes Yes 0 6 0 1
S:S:F212 S:S:L125 4.87 1 Yes Yes 8 7 1 2
S:S:F261 S:S:L125 10.96 1 Yes Yes 9 7 2 2
S:S:H211 S:S:W126 3.17 1 Yes Yes 6 5 2 2
S:S:C167 S:S:M207 3.24 1 No Yes 5 5 2 1
S:S:C167 S:S:H211 14.74 1 No Yes 5 6 2 2
S:S:I189 S:S:Y178 6.04 1 Yes Yes 4 3 2 2
S:S:E181 S:S:Y191 5.61 1 Yes Yes 4 6 2 1
S:S:E181 S:S:Y192 13.47 1 Yes Yes 4 5 2 2
S:S:E181 S:S:Y268 10.1 1 Yes Yes 4 6 2 1
S:S:E181 S:S:M288 4.06 1 Yes Yes 4 4 2 2
S:S:F293 S:S:S186 6.61 1 Yes No 5 5 2 1
S:S:K296 S:S:S186 3.06 1 Yes No 7 5 1 1
M:M:?1 S:S:S186 2.99 1 Yes No 0 5 0 1
S:S:I189 S:S:Y191 8.46 1 Yes Yes 4 6 2 1
S:S:F203 S:S:I189 7.54 1 Yes Yes 6 4 2 2
S:S:I189 S:S:M207 7.29 1 Yes Yes 4 5 2 1
S:S:Y191 S:S:Y192 3.97 1 Yes Yes 6 5 1 2
S:S:M207 S:S:Y191 3.59 1 Yes Yes 5 6 1 1
S:S:Y191 S:S:Y268 10.92 1 Yes Yes 6 6 1 1
S:S:A272 S:S:Y191 9.34 0 No Yes 5 6 2 1
M:M:?1 S:S:Y191 3.11 1 Yes Yes 0 6 0 1
S:S:M288 S:S:Y192 5.99 1 Yes Yes 4 5 2 2
S:S:F203 S:S:M207 4.98 1 Yes Yes 6 5 2 1
M:M:?1 S:S:M207 6.57 1 Yes Yes 0 5 0 1
S:S:F212 S:S:L216 9.74 1 Yes No 8 7 1 2
S:S:F212 S:S:F261 3.22 1 Yes Yes 8 9 1 2
M:M:?1 S:S:F212 8.09 1 Yes Yes 0 8 0 1
S:S:F261 S:S:W265 14.03 1 Yes Yes 9 8 2 1
S:S:C264 S:S:W265 10.45 0 No Yes 8 8 2 1
S:S:A295 S:S:W265 7.78 0 No Yes 8 8 2 1
S:S:S298 S:S:W265 8.65 0 No Yes 9 8 2 1
M:M:?1 S:S:W265 15.13 1 Yes Yes 0 8 0 1
S:S:M288 S:S:Y268 5.99 1 Yes Yes 4 6 2 1
M:M:?1 S:S:Y268 17.13 1 Yes Yes 0 6 0 1
S:S:F293 S:S:K296 9.93 1 Yes Yes 5 7 2 1
M:M:?1 S:S:K296 7.49 1 Yes Yes 0 7 0 1
S:S:E113 S:S:T93 2.82 1 Yes Yes 5 5 1 2
M:M:?1 S:S:A269 2.09 1 Yes No 0 7 0 1
S:S:F212 S:S:I213 1.26 1 Yes No 8 4 1 2
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub8.00
Average Interaction Strength7.56
Average Nodes In Shell40.00
Average Hubs In Shell25.00
Average Links In Shell61.00
Average Links Mediated by Hubs In Shell60.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8IU2 A Sensory Opsins Opsin1LW Homo sapiens Retinal - Gi1/Beta1/Gamma2 3.35 2024-03-27 To be published

A 2D representation of the interactions of RET in 8IU2
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:K312 R:R:V133 3.04 14 No Yes 7 6 1 1
L:L:?1 R:R:V133 2.97 14 Yes Yes 0 6 0 1
R:R:L141 R:R:W281 6.83 0 No Yes 8 8 2 1
R:R:P205 R:R:Y194 2.78 0 No Yes 5 4 1 2
R:R:G204 R:R:H197 3.18 0 No Yes 3 3 2 2
R:R:F208 R:R:H197 7.92 14 Yes Yes 5 3 2 2
R:R:H197 R:R:Y284 3.27 14 Yes Yes 3 6 2 1
R:R:G204 R:R:P205 4.06 0 No No 3 5 2 1
L:L:?1 R:R:P205 7.63 14 Yes No 0 5 0 1
R:R:M220 R:R:V207 7.61 0 No No 5 5 1 2
R:R:F208 R:R:Y284 8.25 14 Yes Yes 5 6 2 1
R:R:F208 R:R:P307 4.33 14 Yes Yes 5 6 2 2
R:R:M220 R:R:Y219 5.99 0 No Yes 5 6 1 2
L:L:?1 R:R:M220 2.82 14 Yes No 0 5 0 1
R:R:C280 R:R:W281 5.22 0 No Yes 8 8 2 1
R:R:A311 R:R:W281 3.89 0 No Yes 7 8 2 1
L:L:?1 R:R:W281 5.3 14 Yes Yes 0 8 0 1
R:R:P307 R:R:Y284 4.17 14 Yes Yes 6 6 2 1
L:L:?1 R:R:Y284 16.35 14 Yes Yes 0 6 0 1
L:L:?1 R:R:K312 6.56 14 Yes No 0 7 0 1
L:L:?1 R:R:C228 2.11 14 Yes No 0 7 0 1
R:R:A106 R:R:V133 1.7 0 No Yes 7 6 2 1
R:R:T132 R:R:V133 1.59 0 No Yes 4 6 2 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub3.00
Average Interaction Strength6.25
Average Nodes In Shell20.00
Average Hubs In Shell9.00
Average Links In Shell23.00
Average Links Mediated by Hubs In Shell21.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links8.10
Average Number Of Links With An Hub4.98
Average Interaction Strength8.44
Average Nodes In Shell27.98
Average Hubs In Shell14.19
Average Links In Shell35.69
Average Links Mediated by Hubs In Shell33.93

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)