psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	H:H:?1	R:R:N15	24.64	No	No	0	0	7
2	H:H:?1	R:R:R21	11.99	No	No	0	0	4
3	L:L:?1	R:R:A117	4.19	Yes	No	0	0	5
4	L:L:?1	R:R:T118	6.86	Yes	Yes	1	0	4
5	L:L:?1	R:R:E122	5.29	Yes	No	1	0	6
6	L:L:?1	R:R:I189	4.75	Yes	No	1	0	4
7	L:L:?1	R:R:M207	14.1	Yes	Yes	1	0	5
8	L:L:?1	R:R:Y268	4.68	Yes	Yes	1	0	6
9	L:L:?1	R:R:K296	9.38	Yes	No	0	0	7
10	R:R:C2	R:R:C282	7.28	No	No	0	6	2
11	R:R:G3	R:R:Y10	4.35	No	No	0	6	7
12	R:R:T4	R:R:V20	11.11	No	No	0	6	6
13	R:R:E5	R:R:Y10	7.86	No	No	0	6	7
14	R:R:E5	R:R:R177	5.82	No	Yes	0	6	5
15	R:R:F9	R:R:G6	6.02	No	No	0	7	6
16	R:R:N8	R:R:P107	4.89	No	No	0	4	3
17	R:R:F9	R:R:S22	7.93	No	No	3	7	5
18	R:R:F9	R:R:P23	17.34	No	Yes	3	7	5
19	R:R:T193	R:R:Y10	9.99	Yes	No	0	5	7
20	R:R:P23	R:R:V11	5.3	Yes	No	3	5	8
21	R:R:L31	R:R:V11	4.47	No	No	0	4	8
22	R:R:Q184	R:R:V11	4.3	No	No	3	3	8
23	R:R:P12	R:R:P285	7.79	No	Yes	5	8	3
24	R:R:F13	R:R:Y30	13.41	No	No	0	4	4
25	R:R:K16	R:R:S14	7.65	No	No	0	7	4
26	R:R:N15	R:R:V20	8.87	No	No	0	7	6
27	R:R:T17	R:R:V19	4.76	No	No	0	6	3
28	R:R:V20	R:R:Y30	7.57	No	No	0	6	4
29	R:R:E25	R:R:R21	8.14	No	No	0	7	4
30	R:R:P23	R:R:S22	5.34	Yes	No	3	5	5
31	R:R:E25	R:R:S22	5.75	No	No	0	7	5
32	R:R:P180	R:R:P23	7.79	Yes	Yes	3	3	5
33	R:R:P23	R:R:Q184	7.9	Yes	No	3	5	3
34	R:R:F103	R:R:F24	8.57	Yes	Yes	3	8	5
35	R:R:F24	R:R:P107	21.67	Yes	No	0	5	3
36	R:R:C110	R:R:F24	5.59	No	Yes	3	9	5
37	R:R:F24	R:R:P180	7.22	Yes	Yes	3	5	3
38	R:R:P27	R:R:Y29	11.13	No	Yes	0	8	4
39	R:R:P27	R:R:Y102	15.3	No	No	0	8	4
40	R:R:Q28	R:R:Y30	14.65	No	No	0	5	4
41	R:R:L31	R:R:Q28	9.32	No	No	0	4	5
42	R:R:P34	R:R:Y29	18.08	No	Yes	0	3	4
43	R:R:F37	R:R:Y29	7.22	No	Yes	6	5	4
44	R:R:G101	R:R:Y29	4.35	No	Yes	6	4	4
45	R:R:L31	R:R:P285	8.21	No	Yes	0	4	3
46	R:R:E33	R:R:Q36	11.47	No	No	0	3	2
47	R:R:F37	R:R:G101	4.52	No	No	6	5	4
48	R:R:F37	R:R:M183	9.95	No	No	0	5	2
49	R:R:L40	R:R:S98	6.01	No	Yes	0	5	5
50	R:R:L47	R:R:Y43	7.03	No	No	0	7	4
51	R:R:F293	R:R:Y43	7.22	No	No	0	5	4
52	R:R:F91	R:R:M44	8.71	Yes	No	0	7	7
53	R:R:M44	R:R:T94	6.02	No	Yes	0	7	7
54	R:R:F45	R:R:M49	9.95	No	No	0	3	5
55	R:R:L46	R:R:L50	4.15	No	No	0	5	5
56	R:R:F91	R:R:L47	7.31	Yes	No	0	7	7
57	R:R:I48	R:R:V87	4.61	No	No	0	6	6
58	R:R:F91	R:R:I48	5.02	Yes	No	0	7	6
59	R:R:I48	R:R:T92	4.56	No	No	0	6	8
60	R:R:F52	R:R:F56	4.29	No	No	0	6	4
61	R:R:F52	R:R:L84	4.87	No	No	0	6	7
62	R:R:F52	R:R:F88	6.43	No	No	0	6	4
63	R:R:A80	R:R:N55	4.69	No	Yes	0	9	9
64	R:R:D83	R:R:N55	12.12	Yes	Yes	7	9	9
65	R:R:L84	R:R:N55	4.12	No	Yes	0	7	9
66	R:R:N55	R:R:P303	8.15	Yes	No	7	9	9
67	R:R:F56	R:R:Y60	5.16	No	No	0	4	3
68	R:R:I307	R:R:T58	9.12	No	No	0	7	9
69	R:R:Q64	R:R:Y60	16.91	No	No	0	5	3
70	R:R:L77	R:R:T62	7.37	No	No	0	5	7
71	R:R:H65	R:R:K67	10.48	No	No	0	5	5
72	R:R:C316	R:R:H65	11.79	No	No	0	5	5
73	R:R:F313	R:R:L68	4.87	No	No	0	8	7
74	R:R:N73	R:R:T70	4.39	No	No	0	8	7
75	R:R:F148	R:R:L72	6.09	Yes	No	0	7	8
76	R:R:F313	R:R:N73	4.83	No	No	0	8	8
77	R:R:E150	R:R:Y74	10.1	No	No	0	2	5
78	R:R:A153	R:R:Y74	5.34	No	No	0	7	5
79	R:R:I75	R:R:N78	4.25	Yes	Yes	2	7	9
80	R:R:I75	R:R:S127	6.19	Yes	No	2	7	8
81	R:R:I75	R:R:V130	6.14	Yes	No	2	7	7
82	R:R:I75	R:R:L131	4.28	Yes	No	0	7	9
83	R:R:E134	R:R:I75	8.2	No	Yes	2	8	7
84	R:R:I307	R:R:L76	4.28	No	No	0	7	8
85	R:R:I123	R:R:N78	4.25	Yes	Yes	2	7	9
86	R:R:N78	R:R:S127	5.96	Yes	No	2	9	8
87	R:R:N78	R:R:V157	10.35	Yes	No	0	9	7
88	R:R:N78	R:R:T160	7.31	Yes	No	2	9	7
89	R:R:N78	R:R:W161	7.91	Yes	No	2	9	9
90	R:R:D83	R:R:L79	5.43	Yes	No	0	9	9
91	R:R:A299	R:R:D83	4.63	No	Yes	0	9	9
92	R:R:D83	R:R:P303	8.05	Yes	No	7	9	9
93	R:R:F116	R:R:F85	4.29	No	No	0	4	6
94	R:R:F85	R:R:L119	4.87	No	Yes	0	6	5
95	R:R:A299	R:R:M86	4.83	No	No	0	9	7
96	R:R:F88	R:R:V87	9.18	No	No	0	4	6
97	R:R:F88	R:R:T92	6.49	No	No	0	4	8
98	R:R:F91	R:R:K296	8.69	Yes	No	0	7	7
99	R:R:E113	R:R:T93	8.47	No	No	0	5	5
100	R:R:E113	R:R:T94	8.47	No	Yes	0	5	7
101	R:R:S186	R:R:T94	4.8	No	Yes	0	5	7
102	R:R:F105	R:R:Y96	6.19	No	No	0	7	4
103	R:R:F103	R:R:T97	7.78	Yes	No	0	8	5
104	R:R:T97	R:R:V104	4.76	No	No	0	5	4
105	R:R:H100	R:R:Y102	9.8	No	No	0	4	4
106	R:R:H100	R:R:V104	8.3	No	No	0	4	4
107	R:R:G101	R:R:Y102	4.35	No	No	0	4	4
108	R:R:C110	R:R:F103	5.59	No	Yes	3	9	8
109	R:R:E113	R:R:F103	8.16	No	Yes	0	5	8
110	R:R:C187	R:R:F103	4.19	No	Yes	3	9	8
111	R:R:C110	R:R:C187	7.28	No	No	3	9	9
112	R:R:L172	R:R:N111	5.49	No	No	0	5	7
113	R:R:N111	R:R:Y178	5.81	No	Yes	0	7	3
114	R:R:G114	R:R:Y178	5.79	No	Yes	0	5	3
115	R:R:F115	R:R:F116	11.79	Yes	No	0	6	4
116	R:R:F115	R:R:L119	6.09	Yes	Yes	0	6	5
117	R:R:F115	R:R:L172	6.09	Yes	No	0	6	5
118	R:R:F115	R:R:Y178	4.13	Yes	Yes	0	6	3
119	R:R:T118	R:R:Y178	6.24	Yes	Yes	0	4	3
120	R:R:I189	R:R:T118	4.56	No	Yes	1	4	4
121	R:R:I123	R:R:L119	5.71	Yes	Yes	0	7	5
122	R:R:C167	R:R:E122	12.15	No	No	1	5	6
123	R:R:E122	R:R:H211	7.39	No	Yes	1	6	6
124	R:R:I123	R:R:W161	9.4	Yes	No	2	7	9
125	R:R:L125	R:R:W126	5.69	No	Yes	1	7	5
126	R:R:F261	R:R:L125	4.87	Yes	No	1	9	7
127	R:R:L125	R:R:W265	11.39	No	No	1	7	8
128	R:R:V129	R:R:W126	7.36	No	Yes	1	7	5
129	R:R:F159	R:R:W126	6.01	No	Yes	1	3	5
130	R:R:M163	R:R:W126	19.78	No	Yes	1	4	5
131	R:R:H211	R:R:W126	8.46	Yes	Yes	1	6	5
132	R:R:P215	R:R:W126	8.11	No	Yes	0	9	5
133	R:R:S127	R:R:T160	4.8	No	No	2	8	7
134	R:R:L128	R:R:N302	4.12	No	No	0	8	9
135	R:R:L128	R:R:Y306	18.76	No	No	0	8	9
136	R:R:E134	R:R:V130	4.28	No	No	2	8	7
137	R:R:L131	R:R:R135	17.01	No	No	0	9	9
138	R:R:L131	R:R:Y306	4.69	No	No	0	9	9
139	R:R:A132	R:R:Y223	9.34	No	Yes	0	9	9
140	R:R:E134	R:R:F148	9.33	No	Yes	2	8	7
141	R:R:R135	R:R:Y223	4.12	No	Yes	4	9	9
142	R:R:R135	R:R:Y257	7.2	No	Yes	4	9	8
143	R:R:C140	R:R:Y136	5.38	No	Yes	0	7	7
144	R:R:P142	R:R:Y136	9.74	No	Yes	0	8	7
145	R:R:F221	R:R:Y136	7.22	No	Yes	8	4	7
146	R:R:C222	R:R:Y136	6.72	No	Yes	0	8	7
147	R:R:Q225	R:R:Y136	4.51	No	Yes	8	4	7
148	R:R:L226	R:R:V139	5.96	No	Yes	0	8	8
149	R:R:C140	R:R:T229	5.07	No	No	0	7	6
150	R:R:F146	R:R:F148	9.65	Yes	Yes	2	5	7
151	R:R:F146	R:R:H152	12.44	Yes	Yes	2	5	5
152	R:R:F148	R:R:H152	4.53	Yes	Yes	2	7	5
153	R:R:F159	R:R:M163	11.2	No	No	1	3	4
154	R:R:C167	R:R:M207	6.48	No	Yes	1	5	5
155	R:R:C167	R:R:H211	5.9	No	Yes	1	5	6
156	R:R:P170	R:R:P171	5.84	No	No	1	7	5
157	R:R:F203	R:R:P170	4.33	Yes	No	1	6	7
158	R:R:P171	R:R:Y178	19.47	No	Yes	0	5	3
159	R:R:F203	R:R:P171	4.33	Yes	No	1	6	5
160	R:R:S202	R:R:W175	8.65	No	Yes	0	4	5
161	R:R:F203	R:R:W175	22.05	Yes	Yes	0	6	5
162	R:R:W175	R:R:Y206	10.61	Yes	Yes	0	5	4
163	R:R:N200	R:R:S176	4.47	Yes	No	0	4	5
164	R:R:F203	R:R:S176	9.25	Yes	No	0	6	5
165	R:R:I179	R:R:R177	10.02	No	Yes	1	1	5
166	R:R:D190	R:R:R177	13.1	Yes	Yes	1	4	5
167	R:R:R177	R:R:T193	5.17	Yes	Yes	1	5	5
168	R:R:H195	R:R:R177	15.8	Yes	Yes	1	4	5
169	R:R:D190	R:R:I179	9.8	Yes	No	1	4	1
170	R:R:I179	R:R:Y192	8.46	No	Yes	1	1	5
171	R:R:P180	R:R:Q184	6.32	Yes	No	3	3	3
172	R:R:C187	R:R:P180	5.65	No	Yes	3	9	3
173	R:R:E181	R:R:G188	4.91	Yes	No	0	4	5
174	R:R:E181	R:R:Y191	7.86	Yes	Yes	1	4	6
175	R:R:E181	R:R:Y192	6.73	Yes	Yes	1	4	5
176	R:R:E181	R:R:Y268	5.61	Yes	Yes	1	4	6
177	R:R:F203	R:R:I189	6.28	Yes	No	1	6	4
178	R:R:D190	R:R:Y192	6.9	Yes	Yes	1	4	5
179	R:R:D190	R:R:T193	14.45	Yes	Yes	1	4	5
180	R:R:D190	R:R:N200	8.08	Yes	Yes	1	4	4
181	R:R:Y191	R:R:Y192	9.93	Yes	Yes	1	6	5
182	R:R:Y191	R:R:Y268	9.93	Yes	Yes	1	6	6
183	R:R:M288	R:R:Y192	4.79	No	Yes	0	4	5
184	R:R:E197	R:R:H195	11.08	No	Yes	0	3	4
185	R:R:H195	R:R:T198	16.43	Yes	No	1	4	1
186	R:R:H195	R:R:N200	5.1	Yes	Yes	1	4	4
187	R:R:N200	R:R:T198	5.85	Yes	No	1	4	1
188	R:R:E201	R:R:F276	4.66	No	No	0	3	4
189	R:R:F203	R:R:M207	9.95	Yes	Yes	1	6	5
190	R:R:F276	R:R:I205	5.02	No	No	0	4	5
191	R:R:V210	R:R:Y206	6.31	No	Yes	1	4	4
192	R:R:H211	R:R:Y206	9.8	Yes	Yes	1	6	4
193	R:R:H211	R:R:M207	9.19	Yes	Yes	1	6	5
194	R:R:F208	R:R:I213	6.28	No	No	0	5	4
195	R:R:F208	R:R:F273	6.43	No	No	0	5	6
196	R:R:H211	R:R:V210	8.3	Yes	No	1	6	4
197	R:R:A269	R:R:F212	8.32	No	No	0	7	8
198	R:R:F220	R:R:L216	12.18	No	No	0	5	7
199	R:R:F261	R:R:L216	4.87	Yes	No	0	9	7
200	R:R:F261	R:R:I219	7.54	Yes	No	0	9	8
201	R:R:F220	R:R:V258	9.18	No	No	0	5	8
202	R:R:F221	R:R:Q225	11.71	No	No	8	4	4
203	R:R:V254	R:R:Y223	7.57	No	Yes	4	8	9
204	R:R:Y223	R:R:Y257	11.91	Yes	Yes	4	9	8
205	R:R:V227	R:R:V254	4.81	No	No	4	5	8
206	R:R:E232	R:R:Q236	6.37	No	No	0	4	2
207	R:R:A234	R:R:Q244	4.55	No	No	0	5	4
208	R:R:A234	R:R:E247	7.54	No	No	0	5	7
209	R:R:S240	R:R:T243	6.4	No	No	0	4	5
210	R:R:E249	R:R:R252	11.63	No	No	0	7	7
211	R:R:E249	R:R:K311	6.75	No	No	0	7	4
212	R:R:M253	R:R:R252	4.96	No	No	0	8	7
213	R:R:M253	R:R:Y257	8.38	No	Yes	0	8	8
214	R:R:M253	R:R:M309	5.78	No	No	0	8	7
215	R:R:I256	R:R:I305	5.89	No	No	0	5	8
216	R:R:Y257	R:R:Y306	26.81	Yes	No	0	8	9
217	R:R:F261	R:R:W265	9.02	Yes	No	1	9	8
218	R:R:C264	R:R:W265	18.28	No	No	0	8	8
219	R:R:C264	R:R:S298	5.16	No	No	0	8	9
220	R:R:F294	R:R:P267	10.11	No	No	0	7	9
221	R:R:P291	R:R:Y268	12.52	No	Yes	0	6	6
222	R:R:P291	R:R:V271	8.84	No	No	0	6	5
223	R:R:F273	R:R:T277	9.08	No	No	0	6	5
224	R:R:H278	R:R:Y274	20.69	No	No	0	3	4
225	R:R:F283	R:R:Y274	5.16	No	No	0	4	4
226	R:R:H278	R:R:T277	5.48	No	No	0	3	5
227	R:R:F283	R:R:F287	21.43	No	No	0	4	4
228	R:R:F287	R:R:I290	7.54	No	No	0	4	5
229	R:R:F293	R:R:F294	11.79	No	No	0	5	7
230	R:R:T297	R:R:Y301	7.49	No	No	0	6	5
231	R:R:N302	R:R:S298	4.47	No	No	0	9	9
232	R:R:F313	R:R:I307	5.02	No	No	0	8	7
233	R:R:K311	R:R:R314	4.95	No	No	0	4	8
234	R:R:G6	R:R:P7	4.06	No	No	0	6	6
235	R:R:G284	R:R:P12	4.06	No	No	5	4	8
236	R:R:G106	R:R:P107	4.06	No	No	0	8	3
237	R:R:G284	R:R:P285	4.06	No	Yes	5	4	3
238	R:R:H152	R:R:M155	3.94	Yes	No	0	5	2
239	R:R:F13	R:R:V19	3.93	No	No	0	4	3
240	R:R:F146	R:R:V137	3.93	Yes	No	0	5	4
241	R:R:E239	R:R:Q238	3.82	No	No	0	2	5
242	R:R:S298	R:R:Y301	3.82	No	No	0	9	5
243	R:R:I256	R:R:R252	3.76	No	No	0	5	7
244	R:R:F146	R:R:M143	3.73	Yes	No	0	5	6
245	R:R:H65	R:R:Q64	3.71	No	No	0	5	5
246	R:R:G120	R:R:I123	3.53	No	Yes	0	8	7
247	R:R:P71	R:R:T70	3.5	No	No	0	6	7
248	R:R:P194	R:R:T193	3.5	No	Yes	0	1	5
249	R:R:C185	R:R:S98	3.44	No	Yes	0	5	5
250	R:R:A41	R:R:S98	3.42	No	Yes	0	5	5
251	R:R:C316	R:R:V61	3.42	No	No	0	5	7
252	R:R:G109	R:R:L112	3.42	No	No	0	5	4
253	R:R:G18	R:R:N15	3.39	No	No	0	3	7
254	R:R:I214	R:R:P215	3.39	No	No	0	5	9
255	R:R:I290	R:R:P291	3.39	No	No	0	5	6
256	R:R:A80	R:R:T58	3.36	No	No	0	9	9
257	R:R:A168	R:R:T118	3.36	No	Yes	0	7	4
258	R:R:A82	R:R:I123	3.25	No	Yes	0	8	7
259	R:R:V129	R:R:V218	3.21	No	No	1	7	6
260	R:R:A241	R:R:K245	3.21	No	No	0	3	4
261	R:R:S98	R:R:T94	3.2	Yes	Yes	0	5	7
262	R:R:T251	R:R:V227	3.17	No	No	0	6	5
263	R:R:A41	R:R:L99	3.15	No	No	0	5	4
264	R:R:I133	R:R:V129	3.07	No	No	1	6	7
265	R:R:I133	R:R:V218	3.07	No	No	1	6	6
266	R:R:I275	R:R:V271	3.07	No	No	0	4	5
267	R:R:K141	R:R:S144	3.06	No	No	0	6	4
268	R:R:A32	R:R:Q36	3.03	No	No	0	3	2
269	R:R:K16	R:R:T17	3	No	No	0	7	6
270	R:R:L57	R:R:V61	2.98	No	No	0	6	7
271	R:R:L262	R:R:V258	2.98	No	No	0	6	8
272	R:R:I213	R:R:I217	2.94	No	No	0	4	4
273	R:R:I255	R:R:I259	2.94	No	No	0	5	5
274	R:R:I259	R:R:I263	2.94	No	No	0	5	5
275	R:R:I54	R:R:M308	2.92	No	No	0	8	6
276	R:R:M308	R:R:M317	2.89	No	No	0	6	6
277	R:R:E247	R:R:V230	2.85	No	No	0	7	8
278	R:R:A26	R:R:R21	2.77	No	No	0	2	4
279	R:R:L95	R:R:L99	2.77	No	No	0	6	4
280	R:R:L119	R:R:L165	2.77	Yes	No	0	5	3
281	R:R:A269	R:R:F208	2.77	No	No	0	7	5
282	R:R:L262	R:R:L266	2.77	No	No	0	6	6
283	R:R:L76	R:R:N310	2.75	No	No	0	8	8
284	R:R:E150	R:R:I154	2.73	No	No	0	2	3
285	R:R:E247	R:R:K231	2.7	No	No	0	7	5
286	R:R:A292	R:R:Y268	2.67	No	Yes	0	5	6
287	R:R:A295	R:R:Y268	2.67	No	Yes	0	8	6
288	R:R:N310	R:R:Q312	2.64	No	No	0	8	6
289	R:R:F85	R:R:V81	2.62	No	No	0	6	6
290	R:R:F105	R:R:T97	2.59	No	No	0	7	5
291	R:R:F276	R:R:T277	2.59	No	No	0	4	5
292	R:R:F294	R:R:I263	2.51	No	No	0	7	5
293	R:R:F45	R:R:L95	2.44	No	No	0	3	6
294	R:R:F116	R:R:L112	2.44	No	No	0	4	4
295	R:R:L46	R:R:Y43	2.34	No	No	0	5	4
296	R:R:N199	R:R:W175	2.26	No	Yes	0	3	5
297	R:R:G89	R:R:G90	2.11	No	No	0	4	6
298	R:R:G120	R:R:G121	2.11	No	No	0	8	7
299	R:R:R69	R:R:Y74	2.06	No	No	0	6	5
300	R:R:G51	R:R:P53	2.03	No	No	0	8	4
301	R:R:G182	R:R:P285	2.03	No	Yes	0	3	3
302	R:R:C2	R:R:G3	1.96	No	No	0	6	6
303	R:R:A117	R:R:G90	1.95	No	No	0	5	6
304	R:R:A269	R:R:G270	1.95	No	No	0	7	5
305	R:R:A153	R:R:P71	1.87	No	No	0	7	6
306	R:R:A169	R:R:P170	1.87	No	No	0	3	7
307	R:R:G280	R:R:S281	1.86	No	No	0	1	4
308	R:R:G51	R:R:V87	1.84	No	No	0	8	6
309	R:R:G51	R:R:V300	1.84	No	No	0	8	7
310	R:R:G156	R:R:V130	1.84	No	No	0	6	7
311	R:R:G109	R:R:T108	1.82	No	No	0	5	1
312	R:R:G174	R:R:T198	1.82	No	No	0	5	1
313	R:R:G182	R:R:T289	1.82	No	No	0	3	4
314	R:R:A132	R:R:C222	1.81	No	No	0	9	8
315	R:R:A124	R:R:A82	1.79	No	No	0	9	8
316	R:R:I54	R:R:P303	1.69	No	No	0	8	9
317	R:R:A233	R:R:T243	1.68	No	No	0	5	5
318	R:R:A234	R:R:T243	1.68	No	No	0	5	5
319	R:R:K141	R:R:P142	1.67	No	No	0	6	8
320	R:R:A164	R:R:I123	1.62	No	Yes	0	8	7
321	R:R:A260	R:R:I305	1.62	No	No	0	7	8
322	R:R:A32	R:R:M183	1.61	No	No	0	3	2
323	R:R:V138	R:R:V139	1.6	No	Yes	0	8	8
324	R:R:V139	R:R:V230	1.6	Yes	No	0	8	8
325	R:R:V227	R:R:V250	1.6	No	No	4	5	8
326	R:R:S240	R:R:T242	1.6	No	No	0	4	4
327	R:R:V250	R:R:V254	1.6	No	No	4	8	8
328	R:R:V300	R:R:V304	1.6	No	No	0	7	7
329	R:R:T229	R:R:V139	1.59	No	Yes	0	6	8
330	R:R:C140	R:R:L226	1.59	No	No	0	7	8
331	R:R:G149	R:R:H152	1.59	No	Yes	0	6	5
332	R:R:I213	R:R:V209	1.54	No	No	0	4	5
333	R:R:L59	R:R:V81	1.49	No	No	0	7	6
334	R:R:L77	R:R:T58	1.47	No	No	0	5	9
335	R:R:Q237	R:R:S240	1.44	No	No	0	5	4
336	R:R:M39	R:R:Q36	1.36	No	No	0	4	2
337	R:R:A166	R:R:Y206	1.33	No	Yes	0	4	4
338	R:R:A272	R:R:Y191	1.33	No	Yes	0	5	6
339	R:R:F283	R:R:S281	1.32	No	No	0	4	4
340	R:R:V204	R:R:Y191	1.26	No	Yes	0	4	6
341	R:R:E232	R:R:F228	1.17	No	No	0	4	3
342	R:R:E33	R:R:W35	1.09	No	No	0	3	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.03571	7	1	0
2	R:R:P23	8.734	5	3	5
3	R:R:F24	10.7625	4	3	5
4	R:R:Y29	10.195	4	6	4
5	R:R:N55	7.27	4	7	9
6	R:R:I75	5.812	5	2	7
7	R:R:N78	6.67167	6	2	9
8	R:R:D83	7.5575	4	7	9
9	R:R:F91	7.4325	4	0	7
10	R:R:T94	5.6225	4	0	7
11	R:R:S98	4.0175	4	0	5
12	R:R:F103	6.858	5	3	8
13	R:R:F115	7.025	4	0	6
14	R:R:T118	5.255	4	1	4
15	R:R:L119	4.86	4	0	5
16	R:R:I123	4.62667	6	2	7
17	R:R:W126	9.235	6	1	5
18	R:R:Y136	6.714	5	8	7
19	R:R:V139	2.6875	4	0	8
20	R:R:F146	7.4375	4	2	5
21	R:R:F148	7.4	4	2	7
22	R:R:H152	5.625	4	2	5
23	R:R:W175	10.8925	4	0	5
24	R:R:R177	9.982	5	1	5
25	R:R:Y178	8.288	5	0	3
26	R:R:P180	6.745	4	3	3
27	R:R:E181	6.2775	4	1	4
28	R:R:D190	10.466	5	1	4
29	R:R:Y191	6.062	5	1	6
30	R:R:Y192	7.362	5	1	5
31	R:R:T193	8.2775	4	1	5
32	R:R:H195	12.1025	4	1	4
33	R:R:N200	5.875	4	1	4
34	R:R:F203	9.365	6	1	6
35	R:R:Y206	7.0125	4	1	4
36	R:R:M207	9.93	4	1	5
37	R:R:H211	8.17333	6	1	6
38	R:R:Y223	8.235	4	4	9
39	R:R:Y257	13.575	4	4	8
40	R:R:F261	6.575	4	1	9
41	R:R:Y268	6.34667	6	1	6
42	R:R:P285	5.5225	4	5	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:P180	R:R:P23	36.6438	7.79	Yes	Yes	3	3	5
2	R:R:F24	R:R:P180	30.6322	7.22	Yes	Yes	3	5	3
3	R:R:F103	R:R:F24	32.9266	8.57	Yes	Yes	3	8	5
4	R:R:E113	R:R:F103	73.807	8.16	No	Yes	0	5	8
5	R:R:E113	R:R:T94	74.6417	8.47	No	Yes	0	5	7
6	R:R:M44	R:R:T94	78.7392	6.02	No	Yes	0	7	7
7	R:R:F91	R:R:M44	79.1284	8.71	Yes	No	0	7	7
8	R:R:F91	R:R:K296	99.9454	8.69	Yes	No	0	7	7
9	L:L:?1	R:R:K296	100	9.38	Yes	No	0	0	7
10	R:R:C187	R:R:P180	30.3997	5.65	No	Yes	3	9	3
11	R:R:C187	R:R:F103	30.9121	4.19	No	Yes	3	9	8
12	L:L:?1	R:R:T118	52.194	6.86	Yes	Yes	1	0	4
13	L:L:?1	R:R:E122	14.8759	5.29	Yes	No	1	0	6
14	L:L:?1	R:R:M207	20.4508	14.1	Yes	Yes	1	0	5
15	L:L:?1	R:R:Y268	34.4427	4.68	Yes	Yes	1	0	6
16	R:R:P23	R:R:V11	21.8665	5.3	Yes	No	3	5	8
17	R:R:Q28	R:R:Y30	21.9898	14.65	No	No	0	5	4
18	R:R:L31	R:R:Q28	24.7103	9.32	No	No	0	4	5
19	R:R:L31	R:R:P285	13.7947	8.21	No	Yes	0	4	3
20	R:R:F13	R:R:Y30	13.7947	13.41	No	No	0	4	4
21	R:R:F13	R:R:V19	11.0424	3.93	No	No	0	4	3
22	R:R:F103	R:R:T97	15.3548	7.78	Yes	No	0	8	5
23	R:R:T97	R:R:V104	13.0146	4.76	No	No	0	5	4
24	R:R:H100	R:R:V104	12.2275	8.3	No	No	0	4	4
25	R:R:H100	R:R:Y102	11.4369	9.8	No	No	0	4	4
26	R:R:F91	R:R:I48	57.6404	5.02	Yes	No	0	7	6
27	R:R:I48	R:R:V87	29.9472	4.61	No	No	0	6	6
28	R:R:I48	R:R:T92	27.158	4.56	No	No	0	6	8
29	R:R:F88	R:R:V87	26.7952	9.18	No	No	0	4	6
30	R:R:F52	R:R:F88	51.9669	6.43	No	No	0	6	4
31	R:R:F88	R:R:T92	26.5276	6.49	No	No	0	4	8
32	R:R:F52	R:R:F56	11.6623	4.29	No	No	0	6	4
33	R:R:F52	R:R:L84	39.7482	4.87	No	No	0	6	7
34	R:R:L84	R:R:N55	38.373	4.12	No	Yes	0	7	9
35	R:R:A80	R:R:N55	25.8373	4.69	No	Yes	0	9	9
36	R:R:F56	R:R:Y60	10.2166	5.16	No	No	0	4	3
37	R:R:A80	R:R:T58	24.4268	3.36	No	No	0	9	9
38	R:R:I307	R:R:T58	20.1743	9.12	No	No	0	7	9
39	R:R:F313	R:R:I307	14.455	5.02	No	No	0	8	7
40	R:R:F313	R:R:N73	11.5742	4.83	No	No	0	8	8
41	R:R:N73	R:R:T70	10.2166	4.39	No	No	0	8	7
42	R:R:T118	R:R:Y178	51.5531	6.24	Yes	Yes	0	4	3
43	R:R:F115	R:R:Y178	54.9709	4.13	Yes	Yes	0	6	3
44	R:R:F115	R:R:L119	50.3927	6.09	Yes	Yes	0	6	5
45	R:R:I123	R:R:L119	48.6195	5.71	Yes	Yes	0	7	5
46	R:R:I123	R:R:N78	45.0291	4.25	Yes	Yes	2	7	9
47	R:R:I75	R:R:N78	43.1555	4.25	Yes	Yes	2	7	9
48	R:R:I75	R:R:L131	38.1863	4.28	Yes	No	0	7	9
49	R:R:E122	R:R:H211	13.7982	7.39	No	Yes	1	6	6
50	R:R:H211	R:R:M207	15.7616	9.19	Yes	Yes	1	6	5
51	R:R:H211	R:R:W126	26.1067	8.46	Yes	Yes	1	6	5
52	R:R:L125	R:R:W126	18.049	5.69	No	Yes	1	7	5
53	R:R:L131	R:R:R135	30.2941	17.01	No	No	0	9	9
54	R:R:R135	R:R:Y223	23.9021	4.12	No	Yes	4	9	9
55	R:R:A132	R:R:Y223	23.7577	9.34	No	Yes	0	9	9
56	R:R:A132	R:R:C222	23.1379	1.81	No	No	0	9	8
57	R:R:C222	R:R:Y136	22.5145	6.72	No	Yes	0	8	7
58	R:R:C140	R:R:Y136	18.7005	5.38	No	Yes	0	7	7
59	R:R:P291	R:R:Y268	17.9292	12.52	No	Yes	0	6	6
60	R:R:I290	R:R:P291	15.5784	3.39	No	No	0	5	6
61	R:R:F287	R:R:I290	14.7878	7.54	No	No	0	4	5
62	R:R:F283	R:R:F287	13.9937	21.43	No	No	0	4	4
63	R:R:F283	R:R:Y274	11.5901	5.16	No	No	0	4	4
64	R:R:H278	R:R:Y274	10.8258	20.69	No	No	0	3	4
65	R:R:H278	R:R:T277	10.0141	5.48	No	No	0	3	5
66	R:R:V139	R:R:V230	13.9778	1.6	Yes	No	0	8	8
67	R:R:E247	R:R:V230	12.5973	2.85	No	No	0	7	8
68	R:R:M253	R:R:Y257	11.7397	8.38	No	Yes	0	8	8
69	R:R:L31	R:R:V11	40.9526	4.47	No	No	0	4	8
70	R:R:Q184	R:R:V11	21.7644	4.3	No	No	3	3	8
71	R:R:P180	R:R:Q184	23.0939	6.32	Yes	No	3	3	3

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:A117	4.19	1	Yes	No	0	5	0	1
L:L:?1	R:R:T118	6.86	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:E122	5.29	1	Yes	No	0	6	0	1
L:L:?1	R:R:I189	4.75	1	Yes	No	0	4	0	1
L:L:?1	R:R:M207	14.1	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Y268	4.68	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:K296	9.38	1	Yes	No	0	7	0	1
R:R:F91	R:R:K296	8.69	0	Yes	No	7	7	2	1
R:R:T118	R:R:Y178	6.24	1	Yes	Yes	4	3	1	2
R:R:I189	R:R:T118	4.56	1	No	Yes	4	4	1	1
R:R:C167	R:R:E122	12.15	1	No	No	5	6	2	1
R:R:E122	R:R:H211	7.39	1	No	Yes	6	6	1	2
R:R:C167	R:R:M207	6.48	1	No	Yes	5	5	2	1
R:R:C167	R:R:H211	5.9	1	No	Yes	5	6	2	2
R:R:E181	R:R:Y191	7.86	1	Yes	Yes	4	6	2	2
R:R:E181	R:R:Y268	5.61	1	Yes	Yes	4	6	2	1
R:R:F203	R:R:I189	6.28	1	Yes	No	6	4	2	1
R:R:Y191	R:R:Y268	9.93	1	Yes	Yes	6	6	2	1
R:R:F203	R:R:M207	9.95	1	Yes	Yes	6	5	2	1
R:R:H211	R:R:M207	9.19	1	Yes	Yes	6	5	2	1
R:R:P291	R:R:Y268	12.52	0	No	Yes	6	6	2	1
R:R:A168	R:R:T118	3.36	0	No	Yes	7	4	2	1
R:R:A292	R:R:Y268	2.67	0	No	Yes	5	6	2	1
R:R:A295	R:R:Y268	2.67	0	No	Yes	8	6	2	1
R:R:A117	R:R:G90	1.95	0	No	No	5	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6FUF_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4.11
Number of Linked Nodes	300
Number of Links	342
Number of Hubs	42
Number of Links mediated by Hubs	156
Number of Communities	8
Number of Nodes involved in Communities	71
Number of Links involved in Communities	97

Path Summary
Number Of Nodes in MetaPath	72
Number Of Links MetaPath	71
Number of Shortest Paths	98026
Length Of Smallest Path	3
Average Path Length	17.7628
Length of Longest Path	42
Minimum Path Strength	1.295
Average Path Strength	7.04238
Maximum Path Strength	22.785
Minimum Path Correlation	0.7
Average Path Correlation	0.930208
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	43.4283
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.0282
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • adenylate cyclase regulator activity • mu-type opioid receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cation binding • metal ion binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • heart process • multicellular organismal process • system process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • behavior • locomotory behavior • transport • secretion • export from cell • membrane docking • establishment of localization • vesicle-mediated transport • localization • organelle localization by membrane tethering • secretion by cell • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex
Gene Ontology	Cellular Component	• cell periphery • postsynapse • cellular anatomical structure • postsynaptic membrane • synapse • cell junction • membrane • plasma membrane • plasma membrane region • synaptic membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • parallel fiber to Purkinje cell synapse • excitatory synapse • presynapse • presynaptic membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • intracellular anatomical structure • cytoplasm • GABA-ergic synapse • glutamatergic synapse • cell body • opsin binding • protein binding • binding • arrestin family protein binding • G protein-coupled photoreceptor activity • molecular transducer activity • photoreceptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • vitamin binding • retinal binding • isoprenoid binding • retinoid binding • lipid binding • 11-cis retinal binding • small molecule binding • G-protein alpha-subunit binding • GTPase regulator activity • enzyme regulator activity • guanyl-nucleotide exchange factor activity • nucleoside-triphosphatase regulator activity • molecular function regulator activity • cation binding • transition metal ion binding • zinc ion binding • ion binding • metal ion binding • identical protein binding • multicellular organismal process • rod bipolar cell differentiation • cellular developmental process • sensory organ development • retina development in camera-type eye • visual system development • neural retina development • neurogenesis • multicellular organism development • eye morphogenesis • neuron differentiation • cell differentiation • anatomical structure development • animal organ morphogenesis • sensory system development • system development • developmental process • camera-type eye morphogenesis • eye development • animal organ development • nervous system development • retinal bipolar neuron differentiation • glutamatergic neuron differentiation • generation of neurons • retina morphogenesis in camera-type eye • anatomical structure morphogenesis • sensory organ morphogenesis • camera-type eye development • cellular process • cellular response to stimulus • response to light stimulus • response to stimulus • cellular response to light stimulus • response to radiation • response to abiotic stimulus • cellular response to radiation • cellular response to abiotic stimulus • cellular response to environmental stimulus • regulation of cellular process • signaling • detection of abiotic stimulus • cell communication • signal transduction • detection of light stimulus • phototransduction • detection of external stimulus • regulation of biological process • biological regulation • detection of visible light • response to external stimulus • detection of stimulus • G protein-coupled receptor signaling pathway • G protein-coupled opsin signaling pathway • phototransduction, visible light • response to light intensity • podosome assembly • organelle assembly • protein-containing complex organization • membraneless organelle assembly • cellular component organization • cellular component biogenesis • organelle organization • cellular component assembly • protein-containing complex assembly • cellular component organization or biogenesis • biosynthetic process • metabolic process • macromolecule metabolic process • gene expression • macromolecule biosynthetic process • multicellular organismal-level homeostasis • homeostatic process • anatomical structure homeostasis • tissue homeostasis • retina homeostasis • photoreceptor cell maintenance • absorption of visible light • light absorption • microtubule cytoskeleton organization • microtubule-based process • cytoskeleton organization • sensory perception of light stimulus • system process • sensory perception • nervous system process • visual perception • thermoception • sensory perception of temperature stimulus • detection of temperature stimulus involved in sensory perception • response to temperature stimulus • detection of temperature stimulus involved in thermoception • detection of temperature stimulus • detection of stimulus involved in sensory perception • taxis • thermotaxis • locomotion • cell-cell junction • anchoring junction • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle • organelle membrane • plasma membrane signaling receptor complex • G protein-coupled receptor complex • receptor complex • sperm midpiece • 9+2 motile cilium • sperm flagellum • motile cilium • photoreceptor inner segment membrane • photoreceptor inner segment • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • cell projection membrane • Golgi membrane • Golgi apparatus • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • outer membrane • sperm head • sperm head plasma membrane • sperm plasma membrane • rod photoreceptor outer segment
SCOP2	Domain Identifier	• G protein-coupled receptor-like
SCOP2	Family Identifier	• G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NAG
PDB Residues	H:H:?1
Environment Details	Open EMBL-EBI Page
Code	NAG
Name	N-Acetylglucosamine
Synonyms	N-Acetylglucosamine
Identifier
Formula	C8 H15 N O6
Molecular Weight	221.208
SMILES
PubChem	24139
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	5
Total Bonds	30
Total Aromatic Bonds	0


Code	RET
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	RET
Name	RETINAL
Synonyms
Identifier
Formula	C20 H28 O
Molecular Weight	284.436
SMILES
PubChem	638015
Formal Charge	0
Total Atoms	49
Total Chiral Atoms	0
Total Bonds	49
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P02699
Sequence	>6FUF_nogp_Chain_R C G T E G P N F Y V P F S N K T G V V R S P F E A P Q Y Y L A E P W Q F S M L A A Y M F L L I M L G F P I N F L T L Y V T V Q H K K L R T P L N Y I L L N L A V A D L F M V F G G F T T T L Y T S L H G Y F V F G P T G C N L E G F F A T L G G E I A L W S L V V L A I E R Y V V V C K P M S N F R F G E N H A I M G V A F T W V M A L A C A A P P L V G W S R Y I P E G M Q C S C G I D Y Y T P H E E T N N E S F V I Y M F V V H F I I P L I V I F F C Y G Q L V F T V K E A A A Q Q Q E S A T T Q K A E K E V T R M V I I Y V I A F L I C W L P Y A G V A F Y I F T H Q G S C F G P I F M T I P A F F A K T S A V Y N P V I Y I M M N K Q F R N C M Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8P13	A	Sensory	Opsin	Rhodopsin	Bos taurus	-	-	Gi1/β1/γT1	5.2	2024-11-20	To be published
	8P13 (No Gprot)	A	Sensory	Opsin	Rhodopsin	Bos taurus	-	-		5.2	2024-11-20	To be published
	8P15	A	Sensory	Opsin	Rhodopsin	Bos taurus	-	-	Gi1/β1/γT1	5.9	2024-11-20	To be published
	8P15 (No Gprot)	A	Sensory	Opsin	Rhodopsin	Bos taurus	-	-		5.9	2024-11-20	To be published
	6FKD	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 137349183	-	2.49	2018-04-04	doi.org/10.1073/pnas.1718084115
	6FKC	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473039	-	2.46	2018-04-04	doi.org/10.1073/pnas.1718084115
	6FKB	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473038	-	3.03	2018-04-04	doi.org/10.1073/pnas.1718084115
	6FKA	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473037	-	2.7	2018-04-04	doi.org/10.1073/pnas.1718084115
	6FK9	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473036	-	2.63	2018-04-04	doi.org/10.1073/pnas.1718084115
	6FK8	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473035	-	2.87	2018-04-04	doi.org/10.1073/pnas.1718084115
	6FK7	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473034	-	2.62	2018-04-04	doi.org/10.1073/pnas.1718084115
	6FK6	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473033	-	2.36	2018-04-04	doi.org/10.1073/pnas.1718084115
	6PH7	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Nerol	Gt(CT)	2.9	2020-07-01	To be published
	6PH7 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Nerol		2.9	2020-07-01	To be published
	6PGS	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Geraniol	Gt(CT)	2.9	2020-07-01	To be published
	6PGS (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Geraniol		2.9	2020-07-01	To be published
	6PEL	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Citronellol	Gt(CT)	3.19	2020-06-24	To be published
	6PEL (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Citronellol		3.19	2020-06-24	To be published
	2G87	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	2.6	2006-09-02	doi.org/10.1002/anie.200600595
	4J4Q	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl β-D-Glucopyranoside	-	Gt(CT)	2.65	2013-10-30	doi.org/10.1002/anie.201302374
	4J4Q (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl β-D-Glucopyranoside	-		2.65	2013-10-30	doi.org/10.1002/anie.201302374
	3OAX	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.6	2011-01-19	doi.org/10.1016/j.bpj.2010.08.003
	5W0P	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-	Arrestin1	3.01	2017-08-09	doi.org/10.1016/j.cell.2017.07.002
	1U19	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.2	2004-10-12	doi.org/10.1016/j.jmb.2004.07.044
	1GZM	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.65	2003-11-20	doi.org/10.1016/j.jmb.2004.08.090
	2J4Y	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	3.4	2007-09-25	doi.org/10.1016/j.jmb.2007.03.007
	3AYM	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	All-trans-Retinal	-	-	2.8	2011-08-17	doi.org/10.1016/j.jmb.2011.08.044
	3AYN	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	9-cis-Retinal	-	-	2.7	2011-08-17	doi.org/10.1016/j.jmb.2011.08.044
	6OY9	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt/β1/γ1	3.9	2019-07-24	doi.org/10.1016/j.molcel.2019.06.007
	6OY9 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3.9	2019-07-24	doi.org/10.1016/j.molcel.2019.06.007
	6OYA	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt/β1/γ1	3.3	2019-07-24	doi.org/10.1016/j.molcel.2019.06.007
	6OYA (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3.3	2019-07-24	doi.org/10.1016/j.molcel.2019.06.007
	4X1H	A	Sensory	Opsins	Rhodopsin	Bos taurus	Nonyl-β-D-Glucopyranoside	-	Gt(CT)	2.29	2015-11-04	doi.org/10.1016/j.str.2015.09.015
	4X1H (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	Nonyl-β-D-Glucopyranoside	-		2.29	2015-11-04	doi.org/10.1016/j.str.2015.09.015
	1HZX	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.8	2001-07-04	doi.org/10.1021/bi0155091
	4BEZ	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	3.3	2013-04-24	doi.org/10.1038/embor.2013.44
	4BEY	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gt(CT)	2.9	2013-05-08	doi.org/10.1038/embor.2013.44
	4BEY (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		2.9	2013-05-08	doi.org/10.1038/embor.2013.44
	2Z73	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	11-cis-Retinal	-	-	2.5	2008-05-13	doi.org/10.1038/nature06925
	3CAP	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	2.9	2008-06-24	doi.org/10.1038/nature07063
	3DQB	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gt(CT)	3.2	2008-09-23	doi.org/10.1038/nature07330
	3DQB (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		3.2	2008-09-23	doi.org/10.1038/nature07330
	3PQR	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	2.85	2011-03-09	doi.org/10.1038/nature09789
	3PQR (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		2.85	2011-03-09	doi.org/10.1038/nature09789
	3PXO	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	3	2011-03-09	doi.org/10.1038/nature09789
	2X72	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	3	2011-03-16	doi.org/10.1038/nature09795
	2X72 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3	2011-03-16	doi.org/10.1038/nature09795
	4ZWJ	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-	Arrestin1	3.3	2015-07-29	doi.org/10.1038/nature14656
	4PXF	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Arrestin1 Finger Loop	2.75	2014-09-17	doi.org/10.1038/ncomms5801
	5WKT	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Gt(CT)	3.2	2017-12-13	doi.org/10.1038/nprot.2017.135
	5WKT (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-		3.2	2017-12-13	doi.org/10.1038/nprot.2017.135
	8FCZ	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	3.7	2023-08-30	doi.org/10.1038/s41467-023-40911-9
	8FD0	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	3.71	2023-08-30	doi.org/10.1038/s41467-023-40911-9
	8FD1	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.25	2023-08-30	doi.org/10.1038/s41467-023-40911-9
	9EPP	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	11,20-Ethanoretinal	-	chim(Gi1-CtGq)/β1/γ2	4.06	2024-10-23	doi.org/10.1038/s41467-024-53208-2
	9EPP (No Gprot)	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	11,20-Ethanoretinal	-		4.06	2024-10-23	doi.org/10.1038/s41467-024-53208-2
	9EPQ	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	11,20-Ethanoretinal	-	chim(Gi1-CtGq)/β1/γ2	4.15	2024-10-23	doi.org/10.1038/s41467-024-53208-2
	9EPQ (No Gprot)	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	11,20-Ethanoretinal	-		4.15	2024-10-23	doi.org/10.1038/s41467-024-53208-2
	6CMO	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-	Gi1/β1/γ2	4.5	2018-06-20	doi.org/10.1038/s41586-018-0215-y
	6CMO (No Gprot)	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-		4.5	2018-06-20	doi.org/10.1038/s41586-018-0215-y
	7MT8	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	GRK1	5.8	2021-07-07	doi.org/10.1038/s41586-021-03721-x
	7MT9	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	GRK1	7	2021-07-07	doi.org/10.1038/s41586-021-03721-x
	7MTA	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	GRK1	4.1	2021-07-07	doi.org/10.1038/s41586-021-03721-x
	7MTB	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	GRK1	4	2021-07-07	doi.org/10.1038/s41586-021-03721-x
	7ZBC	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	1.8	2023-03-29	doi.org/10.1038/s41586-023-05863-6
	7ZBE	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	1.8	2023-03-29	doi.org/10.1038/s41586-023-05863-6
	8A6C	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	1.8	2023-03-29	doi.org/10.1038/s41586-023-05863-6
	8A6D	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	1.8	2023-03-29	doi.org/10.1038/s41586-023-05863-6
	8A6E	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	1.8	2023-03-29	doi.org/10.1038/s41586-023-05863-6
	5DGY	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-	Arrestin1	7.7	2016-03-23	doi.org/10.1038/sdata.2016.21
	2HPY	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	2.8	2006-08-22	doi.org/10.1073/pnas.0601765103
	2I35	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	3.8	2006-10-17	doi.org/10.1073/pnas.0608022103
	2I36	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.1	2006-10-17	doi.org/10.1073/pnas.0608022103
	2I37	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.15	2006-10-17	doi.org/10.1073/pnas.0608022103
	1L9H	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.6	2002-05-15	doi.org/10.1073/pnas.082666399
	4A4M	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	3.3	2012-01-25	doi.org/10.1073/pnas.1114089108
	4A4M (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3.3	2012-01-25	doi.org/10.1073/pnas.1114089108
	5TE3	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	-	2.7	2017-03-15	doi.org/10.1073/pnas.1617446114
	5TE5	A	Sensory	Opsins	Rhodopsin	Bos taurus	20-Methanoretinal	-	-	4.01	2017-03-15	doi.org/10.1073/pnas.1617446114
	6I9K	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	9-cis-Retinal	-	-	2.15	2019-07-03	doi.org/10.1073/pnas.1902192116
	2ZIY	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	11-cis-Retinal	-	-	3.7	2008-05-06	doi.org/10.1074/jbc.C800040200
	6OFJ	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.5	2019-08-21	doi.org/10.1074/jbc.RA119.010089
	3C9L	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.65	2008-08-05	doi.org/10.1107/S0907444908017162
	3C9M	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	3.4	2008-08-05	doi.org/10.1107/S0907444908017162
	6FUF	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Go	3.12	2018-10-03	doi.org/10.1126/sciadv.aat7052
	6FUF (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3.12	2018-10-03	doi.org/10.1126/sciadv.aat7052
	1F88	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.8	2000-08-04	doi.org/10.1126/science.289.5480.739
	4WW3	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	All-trans-Retinal	-	-	2.8	2015-06-17	doi.org/10.1371/journal.pone.0126970
	5DYS	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	2.3	2016-08-10	doi.org/10.15252/embr.201642671
	5EN0	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	2.81	2016-08-10	doi.org/10.15252/embr.201642671
	5EN0 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		2.81	2016-08-10	doi.org/10.15252/embr.201642671
	2PED	A	Sensory	Opsins	Rhodopsin	Bos taurus	9-cis-Retinal	-	-	2.95	2007-10-30	doi.org/10.1529/biophysj.107.108225
	6QNO	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gi1/β1/γ1	4.38	2019-07-10	doi.org/10.7554/eLife.46041
	6QNO (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		4.38	2019-07-10	doi.org/10.7554/eLife.46041
	9EPR	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	Retinal	-	Gi1/β1/γ2	4.9	2024-10-30	doi.org/10.1038/s41467-024-53208-2
	9EPR (No Gprot)	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	Retinal	-		4.9	2024-10-30	doi.org/10.1038/s41467-024-53208-2
	6NWE	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Gt(CT)	2.71	2020-02-12	To be published
	6NWE (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-		2.71	2020-02-12	To be published
	8P12	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gi1/β1/γT1	3.21	2024-11-20	To be published
	8P12 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		3.21	2024-11-20	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 6FUF_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.