psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:M103	4.17	Yes	No	0	0	7
2	L:L:?1	R:R:W290	10.91	Yes	No	0	0	8
3	L:L:?1	R:R:K321	9.35	Yes	No	0	0	7
4	R:R:I21	R:R:P44	5.08	No	No	0	4	3
5	R:R:D25	R:R:S22	4.42	No	No	0	8	7
6	R:R:V24	R:R:Y40	15.14	No	No	0	6	4
7	R:R:L27	R:R:P28	4.93	Yes	No	0	4	5
8	R:R:L27	R:R:M31	11.31	Yes	Yes	1	4	6
9	R:R:L27	R:R:W116	3.42	Yes	Yes	1	4	8
10	R:R:L27	R:R:M197	4.24	Yes	No	0	4	3
11	R:R:P28	R:R:V117	3.53	No	No	0	5	4
12	R:R:D30	R:R:P120	11.27	No	No	0	6	3
13	R:R:I35	R:R:M31	10.2	No	Yes	1	7	6
14	R:R:M31	R:R:W116	3.49	Yes	Yes	1	6	8
15	R:R:M31	R:R:P193	6.71	Yes	Yes	1	6	3
16	R:R:L32	R:R:Y40	5.86	No	No	0	6	4
17	R:R:C123	R:R:M34	3.24	No	No	0	9	4
18	R:R:I35	R:R:P193	5.08	No	Yes	1	7	3
19	R:R:H36	R:R:I205	13.26	No	Yes	0	7	4
20	R:R:D206	R:R:H36	8.82	Yes	No	0	4	7
21	R:R:H38	R:R:K41	11.79	Yes	No	4	8	6
22	R:R:F42	R:R:H38	7.92	Yes	Yes	4	5	8
23	R:R:H38	R:R:R305	5.64	Yes	No	0	8	4
24	R:R:H38	R:R:L308	5.14	Yes	No	0	8	5
25	R:R:F42	R:R:W39	7.02	Yes	Yes	0	5	6
26	R:R:G195	R:R:W39	8.44	No	Yes	0	3	6
27	R:R:I205	R:R:W39	3.52	Yes	Yes	0	4	6
28	R:R:L308	R:R:W39	10.25	No	Yes	0	5	6
29	R:R:F42	R:R:K41	16.13	Yes	No	4	5	6
30	R:R:F42	R:R:P310	5.78	Yes	No	0	5	3
31	R:R:M45	R:R:S196	7.67	No	Yes	0	6	4
32	R:R:E46	R:R:S48	7.19	No	No	0	4	5
33	R:R:C111	R:R:H50	8.85	No	No	2	5	5
34	R:R:E114	R:R:H50	20.92	No	No	0	3	5
35	R:R:H50	R:R:T198	4.11	No	Yes	2	5	4
36	R:R:L53	R:R:V314	5.96	No	No	0	5	4
37	R:R:I318	R:R:L53	5.71	No	No	0	5	5
38	R:R:I57	R:R:M104	5.83	Yes	Yes	0	7	7
39	R:R:I57	R:R:M107	7.29	Yes	No	0	7	7
40	R:R:I57	R:R:K321	5.82	Yes	No	0	7	7
41	R:R:I58	R:R:M104	4.37	No	Yes	5	4	7
42	R:R:I58	R:R:S108	4.64	No	No	5	4	5
43	R:R:F112	R:R:I58	3.77	No	No	0	5	4
44	R:R:G61	R:R:L100	3.42	No	No	0	5	6
45	R:R:C325	R:R:S64	5.16	No	No	0	6	8
46	R:R:G67	R:R:S66	3.71	No	No	0	8	3
47	R:R:A93	R:R:N68	4.69	No	Yes	0	9	9
48	R:R:D96	R:R:N68	5.39	No	Yes	0	9	9
49	R:R:F97	R:R:N68	3.62	Yes	Yes	0	6	9
50	R:R:N68	R:R:P328	8.15	Yes	No	0	9	9
51	R:R:F97	R:R:M72	8.71	Yes	No	0	6	7
52	R:R:L342	R:R:L74	9.69	No	No	0	6	7
53	R:R:L90	R:R:M75	7.07	No	No	0	6	7
54	R:R:K345	R:R:T77	12.01	No	No	0	4	6
55	R:R:L81	R:R:V78	5.96	Yes	No	0	8	6
56	R:R:K79	R:R:R82	12.38	No	No	0	6	8
57	R:R:L81	R:R:N80	4.12	Yes	No	0	8	5
58	R:R:L81	R:R:N86	6.87	Yes	No	6	8	9
59	R:R:K337	R:R:L81	5.64	No	Yes	0	6	8
60	R:R:L81	R:R:Y338	4.69	Yes	Yes	6	8	8
61	R:R:F87	R:R:R82	3.21	No	No	0	5	8
62	R:R:P84	R:R:T83	3.5	Yes	No	0	6	7
63	R:R:N86	R:R:T83	13.16	No	No	0	9	7
64	R:R:L161	R:R:P84	4.93	No	Yes	0	5	6
65	R:R:K163	R:R:P84	3.35	No	Yes	0	2	6
66	R:R:N86	R:R:Y338	9.3	No	Yes	6	9	8
67	R:R:F87	R:R:K163	6.2	No	No	0	5	2
68	R:R:I144	R:R:L88	5.71	No	No	0	9	7
69	R:R:D147	R:R:L88	4.07	No	No	0	8	7
70	R:R:V89	R:R:Y331	3.79	No	Yes	0	7	9
71	R:R:N91	R:R:S140	7.45	No	No	0	9	8
72	R:R:M170	R:R:N91	8.41	No	No	0	7	9
73	R:R:N91	R:R:W174	4.52	No	No	0	9	9
74	R:R:L92	R:R:S140	9.01	No	No	0	9	8
75	R:R:A324	R:R:D96	4.63	No	No	0	9	9
76	R:R:F97	R:R:G98	4.52	Yes	No	0	6	7
77	R:R:F101	R:R:F97	9.65	No	Yes	0	4	6
78	R:R:F133	R:R:G98	4.52	Yes	No	0	7	7
79	R:R:M103	R:R:M99	8.66	No	No	0	7	7
80	R:R:F133	R:R:M99	9.95	Yes	No	0	7	7
81	R:R:F101	R:R:F102	5.36	No	No	0	4	4
82	R:R:F102	R:R:I129	3.77	No	No	7	4	4
83	R:R:F102	R:R:F133	5.36	No	Yes	7	4	7
84	R:R:M103	R:R:Y126	9.58	No	Yes	0	7	5
85	R:R:M104	R:R:P105	5.03	Yes	No	0	7	7
86	R:R:M104	R:R:S108	6.13	Yes	No	5	7	5
87	R:R:M107	R:R:Y126	4.79	No	Yes	0	7	5
88	R:R:M107	R:R:T198	4.52	No	Yes	0	7	4
89	R:R:N110	R:R:W116	11.3	No	Yes	0	5	8
90	R:R:C111	R:R:T198	5.07	No	Yes	2	5	4
91	R:R:T115	R:R:V117	9.52	No	No	0	4	4
92	R:R:I118	R:R:W116	11.74	No	Yes	0	6	8
93	R:R:C123	R:R:W116	9.14	No	Yes	1	9	8
94	R:R:C200	R:R:W116	5.22	No	Yes	1	9	8
95	R:R:I118	R:R:M122	8.75	No	No	0	6	5
96	R:R:G119	R:R:P120	4.06	No	No	0	7	3
97	R:R:E124	R:R:F121	5.83	No	No	0	5	1
98	R:R:L125	R:R:M122	4.24	No	No	0	5	5
99	R:R:C123	R:R:C200	7.28	No	No	1	9	9
100	R:R:S199	R:R:Y126	8.9	No	Yes	0	4	5
101	R:R:M128	R:R:T181	6.02	No	No	0	6	7
102	R:R:M128	R:R:M185	5.78	No	No	0	6	6
103	R:R:M128	R:R:Y191	5.99	No	Yes	0	6	4
104	R:R:F133	R:R:I129	5.02	Yes	No	7	7	4
105	R:R:S131	R:R:T181	6.4	No	No	0	4	7
106	R:R:S131	R:R:Y218	10.17	No	Yes	0	4	5
107	R:R:L132	R:R:L178	6.92	No	No	0	4	4
108	R:R:L132	R:R:T181	5.9	No	No	0	4	7
109	R:R:S135	R:R:S177	6.52	No	No	0	5	8
110	R:R:S135	R:R:Y218	6.36	No	Yes	8	5	5
111	R:R:S135	R:R:V222	3.23	No	No	8	5	5
112	R:R:I138	R:R:P226	6.77	No	No	0	7	9
113	R:R:I138	R:R:W286	5.87	No	Yes	0	7	9
114	R:R:V142	R:R:W139	3.68	No	Yes	0	7	5
115	R:R:W139	R:R:W176	9.37	Yes	No	0	5	3
116	R:R:V222	R:R:W139	6.13	No	Yes	0	5	5
117	R:R:L141	R:R:W286	4.56	No	Yes	0	8	9
118	R:R:L141	R:R:Y331	3.52	No	Yes	0	8	9
119	R:R:P226	R:R:V142	3.53	No	No	0	9	7
120	R:R:I229	R:R:V142	4.61	No	No	0	6	7
121	R:R:I230	R:R:T145	6.08	No	No	0	8	8
122	R:R:C233	R:R:T145	3.38	No	No	0	6	8
123	R:R:T145	R:R:Y234	6.24	No	Yes	0	8	9
124	R:R:D147	R:R:L161	6.79	No	No	0	8	5
125	R:R:R148	R:R:Y234	4.12	No	Yes	0	9	9
126	R:R:R148	R:R:Y331	7.2	No	Yes	0	9	9
127	R:R:V153	R:R:Y149	11.36	No	No	0	7	8
128	R:R:C233	R:R:Y149	9.41	No	No	0	6	8
129	R:R:F236	R:R:Y149	3.09	No	No	0	4	8
130	R:R:I152	R:R:I237	7.36	No	No	0	8	9
131	R:R:Q240	R:R:V153	8.6	No	No	0	5	7
132	R:R:T162	R:R:V164	4.76	No	No	0	8	3
133	R:R:W180	R:R:Y218	9.65	No	Yes	0	5	5
134	R:R:F221	R:R:W180	6.01	No	No	0	4	5
135	R:R:A183	R:R:W188	3.89	No	Yes	0	6	6
136	R:R:P184	R:R:Y191	11.13	No	Yes	0	5	4
137	R:R:P184	R:R:Y214	12.52	No	Yes	0	5	7
138	R:R:N210	R:R:W188	13.56	No	Yes	0	3	6
139	R:R:S213	R:R:W188	8.65	No	Yes	0	4	6
140	R:R:W188	R:R:Y214	22.19	Yes	Yes	0	6	7
141	R:R:S189	R:R:Y214	7.63	No	Yes	0	6	7
142	R:R:D203	R:R:R190	9.53	No	No	3	2	4
143	R:R:D206	R:R:R190	5.96	Yes	No	3	4	4
144	R:R:I202	R:R:Y191	4.84	No	Yes	0	5	4
145	R:R:P193	R:R:V192	3.53	Yes	No	0	3	1
146	R:R:D203	R:R:V192	16.07	No	No	0	2	1
147	R:R:C200	R:R:P193	3.77	No	Yes	1	9	3
148	R:R:E194	R:R:T201	4.23	Yes	No	10	4	4
149	R:R:E194	R:R:Y204	6.73	Yes	Yes	10	4	5
150	R:R:E194	R:R:Y293	11.22	Yes	Yes	0	4	6
151	R:R:E194	R:R:S313	5.75	Yes	No	0	4	4
152	R:R:G195	R:R:S313	3.71	No	No	0	3	4
153	R:R:S196	R:R:T198	4.8	Yes	Yes	2	4	4
154	R:R:P310	R:R:S196	3.56	No	Yes	0	3	4
155	R:R:S196	R:R:V314	9.7	Yes	No	2	4	4
156	R:R:T198	R:R:V314	4.76	Yes	No	2	4	4
157	R:R:I202	R:R:T201	4.56	No	No	0	5	4
158	R:R:T201	R:R:Y204	3.75	No	Yes	10	4	5
159	R:R:I202	R:R:Y214	6.04	No	Yes	0	5	7
160	R:R:D203	R:R:D206	10.65	No	Yes	3	2	4
161	R:R:I205	R:R:Y204	3.63	Yes	Yes	0	4	5
162	R:R:I205	R:R:R305	10.02	Yes	No	0	4	4
163	R:R:D206	R:R:P211	3.22	Yes	No	0	4	5
164	R:R:A208	R:R:P211	3.74	No	No	0	3	5
165	R:R:N210	R:R:P211	4.89	No	No	0	3	5
166	R:R:L215	R:R:S297	6.01	No	No	0	5	6
167	R:R:V222	R:R:Y218	12.62	No	Yes	8	5	5
168	R:R:F221	R:R:I220	3.77	No	No	0	4	4
169	R:R:L227	R:R:Y223	3.52	No	Yes	9	6	7
170	R:R:W286	R:R:Y223	6.75	Yes	Yes	9	9	7
171	R:R:F287	R:R:Y223	3.09	No	Yes	0	6	7
172	R:R:L294	R:R:Y223	11.72	No	Yes	0	6	7
173	R:R:P226	R:R:V225	3.53	No	No	0	9	5
174	R:R:L227	R:R:W286	6.83	No	Yes	9	6	9
175	R:R:I230	R:R:I283	4.42	No	No	0	8	8
176	R:R:F236	R:R:Y232	14.44	No	No	0	4	3
177	R:R:A279	R:R:Y234	4	No	Yes	0	7	9
178	R:R:T282	R:R:Y234	6.24	No	Yes	0	8	9
179	R:R:A276	R:R:V238	3.39	No	No	0	7	6
180	R:R:L275	R:R:V241	4.47	No	No	0	7	8
181	R:R:A242	R:R:E272	6.03	No	No	0	5	7
182	R:R:E245	R:R:R249	4.65	No	Yes	0	4	3
183	R:R:E250	R:R:K246	5.4	No	No	0	4	4
184	R:R:L248	R:R:L260	4.15	No	No	0	5	3
185	R:R:L248	R:R:R261	6.07	No	No	0	5	4
186	R:R:A269	R:R:R249	4.15	No	Yes	0	3	3
187	R:R:E264	R:R:N263	6.57	No	No	0	3	3
188	R:R:F273	R:R:K277	6.2	No	No	0	4	7
189	R:R:R274	R:R:V278	6.54	No	No	0	7	8
190	R:R:W286	R:R:W290	5.62	Yes	No	0	9	8
191	R:R:F287	R:R:T291	7.78	No	No	0	6	6
192	R:R:A289	R:R:S323	3.42	No	No	0	8	9
193	R:R:P292	R:R:T291	3.5	No	No	0	9	6
194	R:R:G316	R:R:P292	4.06	No	No	0	5	9
195	R:R:G316	R:R:Y293	4.35	No	Yes	0	5	6
196	R:R:A317	R:R:Y293	4	No	Yes	0	5	6
197	R:R:L296	R:R:S313	7.51	No	No	0	5	4
198	R:R:F298	R:R:F302	6.43	No	No	0	5	5
199	R:R:G300	R:R:R305	4.5	No	No	0	3	4
200	R:R:F302	R:R:I301	10.05	No	No	0	5	4
201	R:R:P310	R:R:T309	3.5	No	No	0	3	3
202	R:R:M311	R:R:T309	4.52	No	No	0	2	3
203	R:R:T309	R:R:T312	3.14	No	No	0	3	4
204	R:R:I318	R:R:W315	4.7	No	No	0	5	3
205	R:R:N327	R:R:S323	4.47	No	No	0	9	9
206	R:R:V330	R:R:Y326	6.31	No	No	0	8	5
207	R:R:N327	R:R:P328	3.26	No	No	0	9	9
208	R:R:V330	R:R:Y331	3.79	No	Yes	0	8	9
209	R:R:I333	R:R:R339	5.01	No	No	0	5	8
210	R:R:H335	R:R:Y338	8.71	No	Yes	0	8	8
211	R:R:K337	R:R:P336	6.69	No	No	0	6	5
212	R:R:I35	R:R:V24	3.07	No	No	0	7	6
213	R:R:I63	R:R:V59	3.07	No	No	0	5	4
214	R:R:I144	R:R:V89	3.07	No	No	0	9	7
215	R:R:I152	R:R:V151	3.07	No	No	0	8	8
216	R:R:M143	R:R:V173	3.04	No	No	0	6	6
217	R:R:F319	R:R:W315	3.01	No	No	0	7	3
218	R:R:L100	R:R:S64	3	No	No	0	6	8
219	R:R:L299	R:R:S303	3	Yes	No	0	4	3
220	R:R:L299	R:R:T295	2.95	Yes	No	0	4	6
221	R:R:I57	R:R:I60	2.94	Yes	No	0	7	7
222	R:R:I216	R:R:I220	2.94	No	No	0	4	4
223	R:R:I231	R:R:I283	2.94	No	No	0	5	8
224	R:R:I23	R:R:M197	2.92	No	No	0	6	3
225	R:R:D25	R:R:V24	2.92	No	No	0	8	6
226	R:R:I301	R:R:M212	2.92	No	No	0	4	1
227	R:R:I257	R:R:K258	2.91	No	No	0	4	5
228	R:R:G127	R:R:Y126	2.9	No	Yes	0	5	5
229	R:R:G127	R:R:Y191	2.9	No	Yes	0	5	4
230	R:R:L100	R:R:M104	2.83	No	Yes	0	6	7
231	R:R:L167	R:R:M170	2.83	No	No	0	1	7
232	R:R:E114	R:R:T47	2.82	No	No	0	3	2
233	R:R:D25	R:R:I21	2.8	No	No	0	8	4
234	R:R:K154	R:R:N150	2.8	No	No	0	5	4
235	R:R:E46	R:R:M49	2.71	No	No	0	4	4
236	R:R:K254	R:R:Q251	2.71	No	No	0	4	5
237	R:R:E250	R:R:K253	2.7	No	No	0	4	2
238	R:R:A320	R:R:Y293	2.67	No	Yes	0	7	6
239	R:R:F97	R:R:V65	2.62	Yes	No	0	6	6
240	R:R:A217	R:R:W180	2.59	No	No	0	4	5
241	R:R:A217	R:R:W188	2.59	No	Yes	0	4	6
242	L:L:?1	R:R:G130	2.52	Yes	No	0	0	6
243	R:R:F172	R:R:I175	2.51	No	No	0	3	4
244	R:R:T77	R:R:Y73	2.5	No	No	0	6	4
245	R:R:T106	R:R:Y126	2.5	No	Yes	0	6	5
246	R:R:M75	R:R:R82	2.48	No	No	0	7	8
247	R:R:M143	R:R:R169	2.48	No	No	0	6	4
248	R:R:S95	R:R:W174	2.47	No	No	0	8	9
249	R:R:E37	R:R:H36	2.46	No	No	0	5	7
250	R:R:V173	R:R:W139	2.45	No	Yes	0	6	5
251	R:R:F87	R:R:L167	2.44	No	No	0	5	1
252	R:R:F97	R:R:L94	2.44	Yes	No	0	6	6
253	R:R:F121	R:R:L125	2.44	No	No	0	1	5
254	R:R:F298	R:R:L299	2.44	No	Yes	0	5	4
255	R:R:T306	R:R:W307	2.43	No	No	0	3	3
256	R:R:E245	R:R:R261	2.33	No	No	0	4	4
257	R:R:F112	R:R:Y51	2.06	No	No	0	5	4
258	R:R:P43	R:R:P44	1.95	No	No	0	7	3
259	R:R:A166	R:R:P84	1.87	No	Yes	0	7	6
260	R:R:G134	R:R:S137	1.86	No	No	0	6	9
261	R:R:G67	R:R:V70	1.84	No	No	0	8	7
262	R:R:G165	R:R:V164	1.84	No	No	0	5	3
263	R:R:G85	R:R:T83	1.82	No	No	0	8	7
264	R:R:G54	R:R:I57	1.76	No	Yes	0	6	7
265	R:R:G119	R:R:I118	1.76	No	No	0	7	6
266	R:R:G179	R:R:I182	1.76	No	No	0	3	5
267	R:R:G69	R:R:M72	1.75	No	No	0	4	7
268	R:R:G134	R:R:M99	1.75	No	No	0	6	7
269	R:R:G158	R:R:K154	1.74	No	No	0	5	5
270	R:R:A136	R:R:S95	1.71	No	No	0	7	8
271	R:R:A136	R:R:S177	1.71	No	No	0	7	8
272	R:R:G165	R:R:L168	1.71	No	No	0	5	1
273	R:R:G179	R:R:L178	1.71	No	No	0	3	4
274	R:R:A252	R:R:S259	1.71	No	No	0	3	6
275	R:R:A93	R:R:V71	1.7	No	No	0	9	9
276	R:R:A341	R:R:V78	1.7	No	No	0	6	6
277	R:R:A279	R:R:V238	1.7	No	No	0	7	6
278	R:R:A113	R:R:T115	1.68	No	No	0	5	4
279	R:R:K159	R:R:P160	1.67	No	No	0	4	4
280	R:R:L26	R:R:P44	1.64	No	No	0	4	3
281	R:R:L32	R:R:P33	1.64	No	No	0	6	3
282	R:R:C325	R:R:I63	1.64	No	No	0	6	5
283	R:R:C233	R:R:L146	1.59	No	No	0	6	6
284	R:R:A341	R:R:L74	1.58	No	No	0	6	7
285	R:R:E29	R:R:P28	1.57	No	No	0	3	5
286	R:R:C285	R:R:N327	1.57	No	No	0	6	9
287	R:R:I109	R:R:S108	1.55	No	No	0	4	5
288	R:R:I301	R:R:S297	1.55	No	No	0	4	6
289	R:R:I62	R:R:V65	1.54	No	No	0	5	6
290	R:R:I237	R:R:V153	1.54	No	No	0	9	7
291	R:R:K345	R:R:V78	1.52	No	No	0	4	6
292	R:R:M212	R:R:T207	1.51	No	No	0	1	3
293	R:R:L74	R:R:V70	1.49	No	No	0	7	7
294	R:R:L275	R:R:V238	1.49	No	No	0	7	6
295	R:R:D304	R:R:T306	1.45	No	No	0	1	3
296	R:R:G332	R:R:Y338	1.45	No	Yes	0	6	8
297	R:R:K254	R:R:M255	1.44	No	No	0	4	4
298	R:R:I60	R:R:L56	1.43	No	No	0	7	3
299	R:R:E272	R:R:V241	1.43	No	No	0	7	8
300	R:R:E46	R:R:T47	1.41	No	No	0	4	2
301	R:R:H335	R:R:S334	1.39	No	No	0	8	7
302	R:R:L161	R:R:N150	1.37	No	No	0	5	4
303	R:R:R261	R:R:S259	1.32	No	No	0	4	6
304	R:R:F224	R:R:I220	1.26	No	No	0	4	4
305	R:R:F280	R:R:I283	1.26	No	No	0	5	8
306	R:R:D344	R:R:H343	1.26	No	No	0	4	4
307	R:R:K253	R:R:R249	1.24	No	Yes	0	2	3
308	R:R:L215	R:R:Y204	1.17	No	Yes	0	5	5
309	R:R:E272	R:R:R249	1.16	No	Yes	0	7	3
310	R:R:L299	R:R:W307	1.14	Yes	No	0	4	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	6.7375	4	0	0
2	R:R:L27	5.975	4	1	4
3	R:R:M31	7.9275	4	1	6
4	R:R:H38	7.6225	4	4	8
5	R:R:W39	7.3075	4	0	6
6	R:R:F42	9.2125	4	4	5
7	R:R:I57	4.728	5	0	7
8	R:R:N68	5.4625	4	0	9
9	R:R:L81	5.456	5	6	8
10	R:R:P84	3.4125	4	0	6
11	R:R:F97	5.26	6	0	6
12	R:R:M104	4.838	5	5	7
13	R:R:W116	7.385	6	1	8
14	R:R:Y126	5.734	5	0	5
15	R:R:F133	6.2125	4	7	7
16	R:R:W139	5.4075	4	0	5
17	R:R:W188	10.176	5	0	6
18	R:R:Y191	6.215	4	0	4
19	R:R:P193	4.7725	4	1	3
20	R:R:E194	6.9825	4	10	4
21	R:R:S196	6.4325	4	2	4
22	R:R:T198	4.652	5	2	4
23	R:R:Y204	3.82	4	10	5
24	R:R:I205	7.6075	4	0	4
25	R:R:D206	7.1625	4	3	4
26	R:R:Y214	12.095	4	0	7
27	R:R:Y218	9.7	4	8	5
28	R:R:Y223	6.27	4	9	7
29	R:R:Y234	5.15	4	0	9
30	R:R:R249	2.8	4	0	3
31	R:R:W286	5.926	5	9	9
32	R:R:Y293	5.56	4	0	6
33	R:R:L299	2.3825	4	0	4
34	R:R:Y331	4.575	4	0	9
35	R:R:Y338	6.0375	4	6	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:M103	48.7821	4.17	Yes	No	0	0	7
2	R:R:M103	R:R:Y126	73.368	9.58	No	Yes	0	7	5
3	R:R:G127	R:R:Y126	68.8551	2.9	No	Yes	0	5	5
4	R:R:G127	R:R:Y191	69.4053	2.9	No	Yes	0	5	4
5	R:R:P184	R:R:Y191	21.6864	11.13	No	Yes	0	5	4
6	R:R:P184	R:R:Y214	21.0992	12.52	No	Yes	0	5	7
7	R:R:W188	R:R:Y214	46.9152	22.19	Yes	Yes	0	6	7
8	R:R:N210	R:R:W188	55.0569	13.56	No	Yes	0	3	6
9	R:R:N210	R:R:P211	53.1775	4.89	No	No	0	3	5
10	R:R:D206	R:R:P211	50.3956	3.22	Yes	No	0	4	5
11	R:R:D203	R:R:D206	93.2678	10.65	No	Yes	3	2	4
12	R:R:D203	R:R:V192	91.7965	16.07	No	No	0	2	1
13	R:R:P193	R:R:V192	90.0284	3.53	Yes	No	0	3	1
14	R:R:I35	R:R:P193	22.7745	5.08	No	Yes	1	7	3
15	R:R:I35	R:R:V24	22.0636	3.07	No	No	0	7	6
16	R:R:D25	R:R:V24	13.384	2.92	No	No	0	8	6
17	R:R:I202	R:R:Y191	49.252	4.84	No	Yes	0	5	4
18	R:R:I202	R:R:Y214	28.6165	6.04	No	Yes	0	5	7
19	R:R:I202	R:R:T201	36.14	4.56	No	No	0	5	4
20	R:R:T201	R:R:Y204	29.0121	3.75	No	Yes	10	4	5
21	R:R:I205	R:R:Y204	48.4854	3.63	Yes	Yes	0	4	5
22	R:R:H36	R:R:I205	55.2794	13.26	No	Yes	0	7	4
23	R:R:D206	R:R:H36	54.2532	8.82	Yes	No	0	4	7
24	R:R:M31	R:R:P193	38.996	6.71	Yes	Yes	1	6	3
25	R:R:L27	R:R:M31	17.0067	11.31	Yes	Yes	1	4	6
26	R:R:L27	R:R:P28	11.1214	4.93	Yes	No	0	4	5
27	R:R:M31	R:R:W116	21.4144	3.49	Yes	Yes	1	6	8
28	R:R:C200	R:R:P193	26.8855	3.77	No	Yes	1	9	3
29	R:R:C200	R:R:W116	20.6355	5.22	No	Yes	1	9	8
30	R:R:I118	R:R:W116	34.069	11.74	No	Yes	0	6	8
31	R:R:G119	R:R:I118	12.8647	1.76	No	No	0	7	6
32	R:R:M107	R:R:Y126	38.5138	4.79	No	Yes	0	7	5
33	R:R:M107	R:R:T198	49.6167	4.52	No	Yes	0	7	4
34	R:R:S196	R:R:T198	30.0569	4.8	Yes	Yes	2	4	4
35	R:R:P310	R:R:S196	30.4896	3.56	No	Yes	0	3	4
36	R:R:F42	R:R:P310	26.459	5.78	Yes	No	0	5	3
37	L:L:?1	R:R:K321	29.4572	9.35	Yes	No	0	0	7
38	R:R:I57	R:R:K321	29.179	5.82	Yes	No	0	7	7
39	R:R:I57	R:R:M107	35.6639	7.29	Yes	No	0	7	7
40	R:R:F42	R:R:W39	22.1192	7.02	Yes	Yes	0	5	6
41	R:R:H50	R:R:T198	15.1273	4.11	No	Yes	2	5	4
42	R:R:E114	R:R:H50	12.6669	20.92	No	No	0	3	5
43	R:R:E114	R:R:T47	10.157	2.82	No	No	0	3	2
44	R:R:L53	R:R:V314	10.0087	5.96	No	No	0	5	4
45	R:R:I57	R:R:M104	25.5502	5.83	Yes	Yes	0	7	7
46	R:R:L100	R:R:M104	12.0487	2.83	No	Yes	0	6	7
47	L:L:?1	R:R:W290	69.3373	10.91	Yes	No	0	0	8
48	R:R:W286	R:R:W290	68.2122	5.62	Yes	No	0	9	8
49	R:R:L141	R:R:W286	100	4.56	No	Yes	0	8	9
50	R:R:L141	R:R:Y331	98.9305	3.52	No	Yes	0	8	9
51	R:R:V89	R:R:Y331	48.5967	3.79	No	Yes	0	7	9
52	R:R:I144	R:R:V89	47.0697	3.07	No	No	0	9	7
53	R:R:I144	R:R:L88	45.5428	5.71	No	No	0	9	7
54	R:R:D147	R:R:L88	44.0158	4.07	No	No	0	8	7
55	R:R:D147	R:R:L161	42.4889	6.79	No	No	0	8	5
56	R:R:L161	R:R:P84	38.8539	4.93	No	Yes	0	5	6
57	R:R:P84	R:R:T83	38.9404	3.5	Yes	No	0	6	7
58	R:R:N86	R:R:T83	35.4661	13.16	No	No	0	9	7
59	R:R:L81	R:R:N86	26.2179	6.87	Yes	No	6	8	9
60	R:R:L81	R:R:V78	19.2198	5.96	Yes	No	0	8	6
61	R:R:A341	R:R:V78	11.6778	1.7	No	No	0	6	6
62	R:R:M103	R:R:M99	58.7475	8.66	No	No	0	7	7
63	R:R:F133	R:R:M99	51.7928	9.95	Yes	No	0	7	7
64	R:R:F133	R:R:G98	42.1427	4.52	Yes	No	0	7	7
65	R:R:F97	R:R:G98	39.7626	4.52	Yes	No	0	6	7
66	R:R:F97	R:R:N68	25.4018	3.62	Yes	Yes	0	6	9
67	R:R:N68	R:R:P328	12.8524	8.15	Yes	No	0	9	9
68	R:R:K163	R:R:P84	23.4978	3.35	No	Yes	0	2	6
69	R:R:F87	R:R:K163	23.0774	6.2	No	No	0	5	2
70	R:R:I138	R:R:W286	20.1409	5.87	No	Yes	0	7	9
71	R:R:I138	R:R:P226	19.2878	6.77	No	No	0	7	9
72	R:R:P226	R:R:V142	17.8289	3.53	No	No	0	9	7
73	R:R:V142	R:R:W139	17.4703	3.68	No	Yes	0	7	5
74	R:R:V222	R:R:W139	18.614	6.13	No	Yes	0	5	5
75	R:R:S135	R:R:S177	32.746	6.52	No	No	0	5	8
76	R:R:A136	R:R:S177	31.2624	1.71	No	No	0	7	8
77	R:R:A136	R:R:S95	29.7787	1.71	No	No	0	7	8
78	R:R:S95	R:R:W174	28.295	2.47	No	No	0	8	9
79	R:R:N91	R:R:W174	27.0462	4.52	No	No	0	9	9
80	R:R:M170	R:R:N91	23.9676	8.41	No	No	0	7	9
81	R:R:F87	R:R:L167	22.6137	2.44	No	No	0	5	1
82	R:R:L167	R:R:M170	22.9909	2.83	No	No	0	1	7
83	R:R:I118	R:R:M122	17.1303	8.75	No	No	0	6	5
84	R:R:L125	R:R:M122	12.8647	4.24	No	No	0	5	5
85	R:R:M128	R:R:Y191	27.2935	5.99	No	Yes	0	6	4
86	R:R:M128	R:R:T181	24.0294	6.02	No	No	0	6	7
87	R:R:S131	R:R:T181	19.1766	6.4	No	No	0	4	7
88	R:R:S131	R:R:Y218	19.4795	10.17	No	Yes	0	4	5
89	R:R:V222	R:R:Y218	15.6837	12.62	No	Yes	8	5	5
90	R:R:L132	R:R:T181	12.0611	5.9	No	No	0	4	7
91	R:R:R148	R:R:Y331	66.2525	7.2	No	Yes	0	9	9
92	R:R:R148	R:R:Y234	64.6266	4.12	No	Yes	0	9	9
93	R:R:T145	R:R:Y234	29.5747	6.24	No	Yes	0	8	9
94	R:R:C233	R:R:T145	20.0235	3.38	No	No	0	6	8
95	R:R:C233	R:R:Y149	16.1165	9.41	No	No	0	6	8
96	R:R:V153	R:R:Y149	10.1632	11.36	No	No	0	7	8
97	R:R:W180	R:R:Y218	36.0781	9.65	No	Yes	0	5	5
98	R:R:A217	R:R:W188	38.8229	2.59	No	Yes	0	4	6
99	R:R:A217	R:R:W180	37.9946	2.59	No	No	0	4	5
100	R:R:F221	R:R:W180	10.6516	6.01	No	No	0	4	5
101	R:R:W286	R:R:Y223	36.6469	6.75	Yes	Yes	9	9	7
102	R:R:F287	R:R:Y223	35.5094	3.09	No	Yes	0	6	7
103	R:R:F287	R:R:T291	34.8974	7.78	No	No	0	6	6
104	R:R:P292	R:R:T291	34.4832	3.5	No	No	0	9	6
105	R:R:G316	R:R:P292	34.4337	4.06	No	No	0	5	9
106	R:R:G316	R:R:Y293	34.953	4.35	No	Yes	0	5	6
107	R:R:L215	R:R:Y204	24.1036	1.17	No	Yes	0	5	5
108	R:R:L215	R:R:S297	22.3232	6.01	No	No	0	5	6
109	R:R:A279	R:R:Y234	35.0952	4	No	Yes	0	7	9
110	R:R:A279	R:R:V238	33.2468	1.7	No	No	0	7	6
111	R:R:L275	R:R:V238	29.5067	1.49	No	No	0	7	6
112	R:R:L275	R:R:V241	27.615	4.47	No	No	0	7	8
113	R:R:E272	R:R:V241	25.7109	1.43	No	No	0	7	8
114	R:R:E272	R:R:R249	21.8719	1.16	No	Yes	0	7	3
115	R:R:E245	R:R:R249	12.092	4.65	No	Yes	0	4	3
116	R:R:E245	R:R:R261	10.089	2.33	No	No	0	4	4
117	R:R:N327	R:R:P328	10.3054	3.26	No	No	0	9	9
118	R:R:E194	R:R:Y293	37.5062	11.22	Yes	Yes	0	4	6
119	R:R:I301	R:R:S297	20.5304	1.55	No	No	0	4	6
120	R:R:F302	R:R:I301	15.0779	10.05	No	No	0	5	4
121	R:R:F298	R:R:F302	13.2357	6.43	No	No	0	5	5
122	R:R:F298	R:R:L299	11.3811	2.44	No	Yes	0	5	4
123	R:R:S135	R:R:Y218	30.3845	6.36	No	Yes	8	5	5
124	R:R:I205	R:R:W39	21.8534	3.52	Yes	Yes	0	4	6
125	R:R:E194	R:R:Y204	31.1325	6.73	Yes	Yes	10	4	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:M103	4.17	0	Yes	No	0	7	0	1
L:L:?1	R:R:W290	10.91	0	Yes	No	0	8	0	1
L:L:?1	R:R:K321	9.35	0	Yes	No	0	7	0	1
R:R:I57	R:R:K321	5.82	0	Yes	No	7	7	2	1
R:R:M103	R:R:M99	8.66	0	No	No	7	7	1	2
R:R:M103	R:R:Y126	9.58	0	No	Yes	7	5	1	2
R:R:W286	R:R:W290	5.62	9	Yes	No	9	8	2	1
L:L:?1	R:R:G130	2.52	0	Yes	No	0	6	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9EPP_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.09
Number of Linked Nodes	295
Number of Links	310
Number of Hubs	35
Number of Links mediated by Hubs	135
Number of Communities	10
Number of Nodes involved in Communities	36
Number of Links involved in Communities	40

Path Summary
Number Of Nodes in MetaPath	126
Number Of Links MetaPath	125
Number of Shortest Paths	51361
Length Of Smallest Path	3
Average Path Length	15.9796
Length of Longest Path	37
Minimum Path Strength	1.2
Average Path Strength	6.025
Maximum Path Strength	17.875
Minimum Path Correlation	0.7
Average Path Correlation	0.951671
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	58.3678
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	35.1881
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body • molecular transducer activity • photoreceptor activity • signaling receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • sensory perception of light stimulus • visual perception • phototransduction • detection of light stimulus • response to light stimulus • detection of external stimulus • response to external stimulus • detection of abiotic stimulus • detection of stimulus • response to abiotic stimulus • response to radiation
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A1H
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A1H
Name	Molidustat
Synonyms	Molidustat Molidustat sodium
Identifier
Formula	C13 H14 N8 O2
Molecular Weight	314.303
SMILES
PubChem	59603622
Formal Charge	0
Total Atoms	37
Total Chiral Atoms	0
Total Bonds	40
Total Aromatic Bonds	11


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	B1B1U5
Sequence	>9EPP_nogp_Chain_R N I S I V D L L P E D M L P M I H E H W Y K F P P M E T S M H Y I L G M L I I V I G I I S V S G N G V V M Y L M M T V K N L R T P G N F L V L N L A L S D F G M L F F M M P T M S I N C F A E T W V I G P F M C E L Y G M I G S L F G S A S I W S L V M I T L D R Y N V I V K G M A G K P L T K V G A L L R M L F V W I W S L G W T I A P M Y G W S R Y V P E G S M T S C T I D Y I D T A I N P M S Y L I A Y A I F V Y F V P L F I I I Y C Y A F I V M Q V A A H E K S L R E Q A K K M N I K S L R S N E A S A E F R L A K V A F M T I C C W F M A W T P Y L T L S F L G I F S D R T W L T P M T S V W G A I F A K A S A C Y N P I V Y G I S H P K Y R A A L H D K F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8P13	A	Sensory	Opsin	Rhodopsin	Bos taurus	-	-	Gi1/β1/γT1	5.2	2024-11-20	To be published
	8P13 (No Gprot)	A	Sensory	Opsin	Rhodopsin	Bos taurus	-	-		5.2	2024-11-20	To be published
	8P15	A	Sensory	Opsin	Rhodopsin	Bos taurus	-	-	Gi1/β1/γT1	5.9	2024-11-20	To be published
	8P15 (No Gprot)	A	Sensory	Opsin	Rhodopsin	Bos taurus	-	-		5.9	2024-11-20	To be published
	6FKD	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 137349183	-	2.49	2018-04-04	doi.org/10.1073/pnas.1718084115
	6FKC	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473039	-	2.46	2018-04-04	doi.org/10.1073/pnas.1718084115
	6FKB	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473038	-	3.03	2018-04-04	doi.org/10.1073/pnas.1718084115
	6FKA	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473037	-	2.7	2018-04-04	doi.org/10.1073/pnas.1718084115
	6FK9	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473036	-	2.63	2018-04-04	doi.org/10.1073/pnas.1718084115
	6FK8	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473035	-	2.87	2018-04-04	doi.org/10.1073/pnas.1718084115
	6FK7	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473034	-	2.62	2018-04-04	doi.org/10.1073/pnas.1718084115
	6FK6	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473033	-	2.36	2018-04-04	doi.org/10.1073/pnas.1718084115
	6PH7	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Nerol	Gt(CT)	2.9	2020-07-01	To be published
	6PH7 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Nerol		2.9	2020-07-01	To be published
	6PGS	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Geraniol	Gt(CT)	2.9	2020-07-01	To be published
	6PGS (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Geraniol		2.9	2020-07-01	To be published
	6PEL	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Citronellol	Gt(CT)	3.19	2020-06-24	To be published
	6PEL (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Citronellol		3.19	2020-06-24	To be published
	2G87	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	2.6	2006-09-02	doi.org/10.1002/anie.200600595
	4J4Q	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl β-D-Glucopyranoside	-	Gt(CT)	2.65	2013-10-30	doi.org/10.1002/anie.201302374
	4J4Q (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl β-D-Glucopyranoside	-		2.65	2013-10-30	doi.org/10.1002/anie.201302374
	3OAX	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.6	2011-01-19	doi.org/10.1016/j.bpj.2010.08.003
	5W0P	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-	Arrestin1	3.01	2017-08-09	doi.org/10.1016/j.cell.2017.07.002
	1U19	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.2	2004-10-12	doi.org/10.1016/j.jmb.2004.07.044
	1GZM	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.65	2003-11-20	doi.org/10.1016/j.jmb.2004.08.090
	2J4Y	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	3.4	2007-09-25	doi.org/10.1016/j.jmb.2007.03.007
	3AYM	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	All-trans-Retinal	-	-	2.8	2011-08-17	doi.org/10.1016/j.jmb.2011.08.044
	3AYN	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	9-cis-Retinal	-	-	2.7	2011-08-17	doi.org/10.1016/j.jmb.2011.08.044
	6OY9	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt/β1/γ1	3.9	2019-07-24	doi.org/10.1016/j.molcel.2019.06.007
	6OY9 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3.9	2019-07-24	doi.org/10.1016/j.molcel.2019.06.007
	6OYA	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt/β1/γ1	3.3	2019-07-24	doi.org/10.1016/j.molcel.2019.06.007
	6OYA (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3.3	2019-07-24	doi.org/10.1016/j.molcel.2019.06.007
	4X1H	A	Sensory	Opsins	Rhodopsin	Bos taurus	Nonyl-β-D-Glucopyranoside	-	Gt(CT)	2.29	2015-11-04	doi.org/10.1016/j.str.2015.09.015
	4X1H (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	Nonyl-β-D-Glucopyranoside	-		2.29	2015-11-04	doi.org/10.1016/j.str.2015.09.015
	1HZX	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.8	2001-07-04	doi.org/10.1021/bi0155091
	4BEZ	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	3.3	2013-04-24	doi.org/10.1038/embor.2013.44
	4BEY	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gt(CT)	2.9	2013-05-08	doi.org/10.1038/embor.2013.44
	4BEY (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		2.9	2013-05-08	doi.org/10.1038/embor.2013.44
	2Z73	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	11-cis-Retinal	-	-	2.5	2008-05-13	doi.org/10.1038/nature06925
	3CAP	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	2.9	2008-06-24	doi.org/10.1038/nature07063
	3DQB	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gt(CT)	3.2	2008-09-23	doi.org/10.1038/nature07330
	3DQB (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		3.2	2008-09-23	doi.org/10.1038/nature07330
	3PQR	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	2.85	2011-03-09	doi.org/10.1038/nature09789
	3PQR (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		2.85	2011-03-09	doi.org/10.1038/nature09789
	3PXO	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	3	2011-03-09	doi.org/10.1038/nature09789
	2X72	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	3	2011-03-16	doi.org/10.1038/nature09795
	2X72 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3	2011-03-16	doi.org/10.1038/nature09795
	4ZWJ	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-	Arrestin1	3.3	2015-07-29	doi.org/10.1038/nature14656
	4PXF	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Arrestin1 Finger Loop	2.75	2014-09-17	doi.org/10.1038/ncomms5801
	5WKT	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Gt(CT)	3.2	2017-12-13	doi.org/10.1038/nprot.2017.135
	5WKT (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-		3.2	2017-12-13	doi.org/10.1038/nprot.2017.135
	8FCZ	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	3.7	2023-08-30	doi.org/10.1038/s41467-023-40911-9
	8FD0	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	3.71	2023-08-30	doi.org/10.1038/s41467-023-40911-9
	8FD1	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.25	2023-08-30	doi.org/10.1038/s41467-023-40911-9
	9EPP	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	11,20-Ethanoretinal	-	chim(Gi1-CtGq)/β1/γ2	4.06	2024-10-23	doi.org/10.1038/s41467-024-53208-2
	9EPP (No Gprot)	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	11,20-Ethanoretinal	-		4.06	2024-10-23	doi.org/10.1038/s41467-024-53208-2
	9EPQ	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	11,20-Ethanoretinal	-	chim(Gi1-CtGq)/β1/γ2	4.15	2024-10-23	doi.org/10.1038/s41467-024-53208-2
	9EPQ (No Gprot)	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	11,20-Ethanoretinal	-		4.15	2024-10-23	doi.org/10.1038/s41467-024-53208-2
	6CMO	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-	Gi1/β1/γ2	4.5	2018-06-20	doi.org/10.1038/s41586-018-0215-y
	6CMO (No Gprot)	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-		4.5	2018-06-20	doi.org/10.1038/s41586-018-0215-y
	7MT8	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	GRK1	5.8	2021-07-07	doi.org/10.1038/s41586-021-03721-x
	7MT9	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	GRK1	7	2021-07-07	doi.org/10.1038/s41586-021-03721-x
	7MTA	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	GRK1	4.1	2021-07-07	doi.org/10.1038/s41586-021-03721-x
	7MTB	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	GRK1	4	2021-07-07	doi.org/10.1038/s41586-021-03721-x
	7ZBC	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	1.8	2023-03-29	doi.org/10.1038/s41586-023-05863-6
	7ZBE	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	1.8	2023-03-29	doi.org/10.1038/s41586-023-05863-6
	8A6C	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	1.8	2023-03-29	doi.org/10.1038/s41586-023-05863-6
	8A6D	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	1.8	2023-03-29	doi.org/10.1038/s41586-023-05863-6
	8A6E	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	1.8	2023-03-29	doi.org/10.1038/s41586-023-05863-6
	5DGY	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-	Arrestin1	7.7	2016-03-23	doi.org/10.1038/sdata.2016.21
	2HPY	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	2.8	2006-08-22	doi.org/10.1073/pnas.0601765103
	2I35	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	3.8	2006-10-17	doi.org/10.1073/pnas.0608022103
	2I36	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.1	2006-10-17	doi.org/10.1073/pnas.0608022103
	2I37	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.15	2006-10-17	doi.org/10.1073/pnas.0608022103
	1L9H	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.6	2002-05-15	doi.org/10.1073/pnas.082666399
	4A4M	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	3.3	2012-01-25	doi.org/10.1073/pnas.1114089108
	4A4M (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3.3	2012-01-25	doi.org/10.1073/pnas.1114089108
	5TE3	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	-	2.7	2017-03-15	doi.org/10.1073/pnas.1617446114
	5TE5	A	Sensory	Opsins	Rhodopsin	Bos taurus	20-Methanoretinal	-	-	4.01	2017-03-15	doi.org/10.1073/pnas.1617446114
	6I9K	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	9-cis-Retinal	-	-	2.15	2019-07-03	doi.org/10.1073/pnas.1902192116
	2ZIY	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	11-cis-Retinal	-	-	3.7	2008-05-06	doi.org/10.1074/jbc.C800040200
	6OFJ	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.5	2019-08-21	doi.org/10.1074/jbc.RA119.010089
	3C9L	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.65	2008-08-05	doi.org/10.1107/S0907444908017162
	3C9M	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	3.4	2008-08-05	doi.org/10.1107/S0907444908017162
	6FUF	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Go	3.12	2018-10-03	doi.org/10.1126/sciadv.aat7052
	6FUF (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3.12	2018-10-03	doi.org/10.1126/sciadv.aat7052
	1F88	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.8	2000-08-04	doi.org/10.1126/science.289.5480.739
	4WW3	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	All-trans-Retinal	-	-	2.8	2015-06-17	doi.org/10.1371/journal.pone.0126970
	5DYS	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	2.3	2016-08-10	doi.org/10.15252/embr.201642671
	5EN0	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	2.81	2016-08-10	doi.org/10.15252/embr.201642671
	5EN0 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		2.81	2016-08-10	doi.org/10.15252/embr.201642671
	2PED	A	Sensory	Opsins	Rhodopsin	Bos taurus	9-cis-Retinal	-	-	2.95	2007-10-30	doi.org/10.1529/biophysj.107.108225
	6QNO	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gi1/β1/γ1	4.38	2019-07-10	doi.org/10.7554/eLife.46041
	6QNO (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		4.38	2019-07-10	doi.org/10.7554/eLife.46041
	9EPR	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	Retinal	-	Gi1/β1/γ2	4.9	2024-10-30	doi.org/10.1038/s41467-024-53208-2
	9EPR (No Gprot)	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	Retinal	-		4.9	2024-10-30	doi.org/10.1038/s41467-024-53208-2
	6NWE	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Gt(CT)	2.71	2020-02-12	To be published
	6NWE (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-		2.71	2020-02-12	To be published
	8P12	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gi1/β1/γT1	3.21	2024-11-20	To be published
	8P12 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		3.21	2024-11-20	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9EPP_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.