psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:M103	5.66	Yes	No	0	0	7
2	L:L:?1	R:R:G130	3.43	Yes	No	0	0	6
3	L:L:?1	R:R:Y218	3.52	Yes	Yes	1	0	5
4	L:L:?1	R:R:W290	14.83	Yes	No	0	0	8
5	L:L:?1	R:R:Y293	3.52	Yes	Yes	1	0	6
6	L:L:?1	R:R:A317	3.16	Yes	No	1	0	5
7	L:L:?1	R:R:K321	12.71	Yes	No	0	0	7
8	R:R:I21	R:R:P44	5.08	No	No	0	4	3
9	R:R:D25	R:R:S22	4.42	No	No	0	8	7
10	R:R:V24	R:R:Y40	15.14	No	No	0	6	4
11	R:R:L27	R:R:P28	4.93	Yes	No	0	4	5
12	R:R:L27	R:R:M31	11.31	Yes	Yes	2	4	6
13	R:R:L27	R:R:W116	3.42	Yes	Yes	2	4	8
14	R:R:L27	R:R:M197	4.24	Yes	No	0	4	3
15	R:R:P28	R:R:V117	3.53	No	No	0	5	4
16	R:R:D30	R:R:P120	11.27	No	No	0	6	3
17	R:R:I35	R:R:M31	10.2	No	Yes	2	7	6
18	R:R:M31	R:R:W116	3.49	Yes	Yes	2	6	8
19	R:R:M31	R:R:P193	6.71	Yes	Yes	2	6	3
20	R:R:L32	R:R:Y40	5.86	No	No	0	6	4
21	R:R:C123	R:R:M34	3.24	No	No	0	9	4
22	R:R:I35	R:R:P193	5.08	No	Yes	2	7	3
23	R:R:H36	R:R:I205	13.26	No	Yes	0	7	4
24	R:R:D206	R:R:H36	8.82	Yes	No	0	4	7
25	R:R:H38	R:R:K41	11.79	Yes	No	5	8	6
26	R:R:F42	R:R:H38	7.92	Yes	Yes	5	5	8
27	R:R:H38	R:R:R305	5.64	Yes	No	0	8	4
28	R:R:H38	R:R:L308	5.14	Yes	No	0	8	5
29	R:R:F42	R:R:W39	7.02	Yes	Yes	0	5	6
30	R:R:G195	R:R:W39	8.44	No	Yes	0	3	6
31	R:R:I205	R:R:W39	3.52	Yes	Yes	0	4	6
32	R:R:L308	R:R:W39	10.25	No	Yes	0	5	6
33	R:R:F42	R:R:K41	16.13	Yes	No	5	5	6
34	R:R:F42	R:R:P310	5.78	Yes	No	0	5	3
35	R:R:M45	R:R:S196	7.67	No	Yes	0	6	4
36	R:R:E46	R:R:S48	7.19	No	No	0	4	5
37	R:R:C111	R:R:H50	8.85	No	No	3	5	5
38	R:R:E114	R:R:H50	20.92	No	No	0	3	5
39	R:R:H50	R:R:T198	4.11	No	Yes	3	5	4
40	R:R:L53	R:R:V314	5.96	No	No	0	5	4
41	R:R:I318	R:R:L53	5.71	No	No	0	5	5
42	R:R:I57	R:R:M104	5.83	Yes	Yes	0	7	7
43	R:R:I57	R:R:M107	7.29	Yes	No	0	7	7
44	R:R:I57	R:R:K321	5.82	Yes	No	0	7	7
45	R:R:I58	R:R:M104	4.37	No	Yes	6	4	7
46	R:R:I58	R:R:S108	4.64	No	No	6	4	5
47	R:R:F112	R:R:I58	3.77	No	No	0	5	4
48	R:R:G61	R:R:L100	3.42	No	No	0	5	6
49	R:R:C325	R:R:S64	5.16	No	No	0	6	8
50	R:R:G67	R:R:S66	3.71	No	No	0	8	3
51	R:R:A93	R:R:N68	4.69	No	Yes	0	9	9
52	R:R:D96	R:R:N68	5.39	No	Yes	0	9	9
53	R:R:F97	R:R:N68	3.62	Yes	Yes	0	6	9
54	R:R:N68	R:R:P328	8.15	Yes	No	0	9	9
55	R:R:F97	R:R:M72	8.71	Yes	No	0	6	7
56	R:R:L342	R:R:L74	9.69	No	No	0	6	7
57	R:R:L90	R:R:M75	7.07	No	No	0	6	7
58	R:R:K345	R:R:T77	12.01	No	No	0	4	6
59	R:R:L81	R:R:V78	5.96	Yes	No	0	8	6
60	R:R:K79	R:R:R82	12.38	No	No	0	6	8
61	R:R:L81	R:R:N80	4.12	Yes	No	0	8	5
62	R:R:L81	R:R:N86	6.87	Yes	No	7	8	9
63	R:R:K337	R:R:L81	5.64	No	Yes	0	6	8
64	R:R:L81	R:R:Y338	4.69	Yes	Yes	7	8	8
65	R:R:F87	R:R:R82	3.21	No	No	0	5	8
66	R:R:P84	R:R:T83	3.5	Yes	No	0	6	7
67	R:R:N86	R:R:T83	13.16	No	No	0	9	7
68	R:R:L161	R:R:P84	4.93	No	Yes	0	5	6
69	R:R:K163	R:R:P84	3.35	No	Yes	0	2	6
70	R:R:N86	R:R:Y338	9.3	No	Yes	7	9	8
71	R:R:F87	R:R:K163	6.2	No	No	0	5	2
72	R:R:I144	R:R:L88	5.71	No	No	0	9	7
73	R:R:D147	R:R:L88	4.07	No	No	0	8	7
74	R:R:V89	R:R:Y331	3.79	No	Yes	0	7	9
75	R:R:N91	R:R:S140	7.45	No	No	0	9	8
76	R:R:M170	R:R:N91	8.41	No	No	0	7	9
77	R:R:N91	R:R:W174	4.52	No	No	0	9	9
78	R:R:L92	R:R:S140	9.01	No	No	0	9	8
79	R:R:A324	R:R:D96	4.63	No	No	0	9	9
80	R:R:F97	R:R:G98	4.52	Yes	No	0	6	7
81	R:R:F101	R:R:F97	9.65	No	Yes	0	4	6
82	R:R:F133	R:R:G98	4.52	Yes	No	0	7	7
83	R:R:M103	R:R:M99	8.66	No	No	0	7	7
84	R:R:F133	R:R:M99	9.95	Yes	No	0	7	7
85	R:R:F101	R:R:F102	5.36	No	No	0	4	4
86	R:R:F102	R:R:I129	3.77	No	No	8	4	4
87	R:R:F102	R:R:F133	5.36	No	Yes	8	4	7
88	R:R:M103	R:R:Y126	9.58	No	Yes	0	7	5
89	R:R:M104	R:R:P105	5.03	Yes	No	0	7	7
90	R:R:M104	R:R:S108	6.13	Yes	No	6	7	5
91	R:R:M107	R:R:Y126	4.79	No	Yes	0	7	5
92	R:R:M107	R:R:T198	4.52	No	Yes	0	7	4
93	R:R:N110	R:R:W116	11.3	No	Yes	0	5	8
94	R:R:C111	R:R:T198	5.07	No	Yes	3	5	4
95	R:R:T115	R:R:V117	9.52	No	No	0	4	4
96	R:R:I118	R:R:W116	11.74	No	Yes	0	6	8
97	R:R:C123	R:R:W116	9.14	No	Yes	2	9	8
98	R:R:C200	R:R:W116	5.22	No	Yes	2	9	8
99	R:R:I118	R:R:M122	8.75	No	No	0	6	5
100	R:R:G119	R:R:P120	4.06	No	No	0	7	3
101	R:R:E124	R:R:F121	5.83	No	No	0	5	1
102	R:R:L125	R:R:M122	4.24	No	No	0	5	5
103	R:R:C123	R:R:C200	7.28	No	No	2	9	9
104	R:R:S199	R:R:Y126	8.9	No	Yes	0	4	5
105	R:R:M128	R:R:T181	6.02	No	No	0	6	7
106	R:R:M128	R:R:M185	5.78	No	No	0	6	6
107	R:R:M128	R:R:Y191	5.99	No	Yes	0	6	4
108	R:R:F133	R:R:I129	5.02	Yes	No	8	7	4
109	R:R:S131	R:R:T181	6.4	No	No	0	4	7
110	R:R:S131	R:R:Y218	10.17	No	Yes	0	4	5
111	R:R:L132	R:R:L178	6.92	No	No	0	4	4
112	R:R:L132	R:R:T181	5.9	No	No	0	4	7
113	R:R:S135	R:R:S177	6.52	No	No	0	5	8
114	R:R:S135	R:R:Y218	6.36	No	Yes	1	5	5
115	R:R:S135	R:R:V222	3.23	No	No	1	5	5
116	R:R:I138	R:R:P226	6.77	No	No	0	7	9
117	R:R:I138	R:R:W286	5.87	No	Yes	0	7	9
118	R:R:V142	R:R:W139	3.68	No	Yes	0	7	5
119	R:R:W139	R:R:W176	9.37	Yes	No	0	5	3
120	R:R:V222	R:R:W139	6.13	No	Yes	0	5	5
121	R:R:L141	R:R:W286	4.56	No	Yes	0	8	9
122	R:R:L141	R:R:Y331	3.52	No	Yes	0	8	9
123	R:R:P226	R:R:V142	3.53	No	No	0	9	7
124	R:R:I229	R:R:V142	4.61	No	No	0	6	7
125	R:R:I230	R:R:T145	6.08	No	No	0	8	8
126	R:R:C233	R:R:T145	3.38	No	No	0	6	8
127	R:R:T145	R:R:Y234	6.24	No	Yes	0	8	9
128	R:R:D147	R:R:L161	6.79	No	No	0	8	5
129	R:R:R148	R:R:Y234	4.12	No	Yes	0	9	9
130	R:R:R148	R:R:Y331	7.2	No	Yes	0	9	9
131	R:R:V153	R:R:Y149	11.36	No	No	0	7	8
132	R:R:C233	R:R:Y149	9.41	No	No	0	6	8
133	R:R:F236	R:R:Y149	3.09	No	No	0	4	8
134	R:R:I152	R:R:I237	7.36	No	No	0	8	9
135	R:R:Q240	R:R:V153	8.6	No	No	0	5	7
136	R:R:T162	R:R:V164	4.76	No	No	0	8	3
137	R:R:W180	R:R:Y218	9.65	No	Yes	0	5	5
138	R:R:F221	R:R:W180	6.01	No	No	0	4	5
139	R:R:A183	R:R:W188	3.89	No	Yes	0	6	6
140	R:R:P184	R:R:Y191	11.13	No	Yes	0	5	4
141	R:R:P184	R:R:Y214	12.52	No	Yes	0	5	7
142	R:R:N210	R:R:W188	13.56	No	Yes	0	3	6
143	R:R:S213	R:R:W188	8.65	No	Yes	0	4	6
144	R:R:W188	R:R:Y214	22.19	Yes	Yes	0	6	7
145	R:R:S189	R:R:Y214	7.63	No	Yes	0	6	7
146	R:R:D203	R:R:R190	9.53	No	No	4	2	4
147	R:R:D206	R:R:R190	5.96	Yes	No	4	4	4
148	R:R:I202	R:R:Y191	4.84	No	Yes	0	5	4
149	R:R:P193	R:R:V192	3.53	Yes	No	0	3	1
150	R:R:D203	R:R:V192	16.07	No	No	0	2	1
151	R:R:C200	R:R:P193	3.77	No	Yes	2	9	3
152	R:R:E194	R:R:T201	4.23	Yes	No	1	4	4
153	R:R:E194	R:R:Y204	6.73	Yes	No	1	4	5
154	R:R:E194	R:R:Y293	11.22	Yes	Yes	1	4	6
155	R:R:E194	R:R:S313	5.75	Yes	No	0	4	4
156	R:R:G195	R:R:S313	3.71	No	No	0	3	4
157	R:R:S196	R:R:T198	4.8	Yes	Yes	3	4	4
158	R:R:P310	R:R:S196	3.56	No	Yes	0	3	4
159	R:R:S196	R:R:V314	9.7	Yes	No	3	4	4
160	R:R:T198	R:R:V314	4.76	Yes	No	3	4	4
161	R:R:I202	R:R:T201	4.56	No	No	0	5	4
162	R:R:T201	R:R:Y204	3.75	No	No	1	4	5
163	R:R:I202	R:R:Y214	6.04	No	Yes	0	5	7
164	R:R:D203	R:R:D206	10.65	No	Yes	4	2	4
165	R:R:I205	R:R:Y204	3.63	Yes	No	0	4	5
166	R:R:I205	R:R:R305	10.02	Yes	No	0	4	4
167	R:R:D206	R:R:P211	3.22	Yes	No	0	4	5
168	R:R:A208	R:R:P211	3.74	No	No	0	3	5
169	R:R:N210	R:R:P211	4.89	No	No	0	3	5
170	R:R:L215	R:R:S297	6.01	No	No	0	5	6
171	R:R:V222	R:R:Y218	12.62	No	Yes	1	5	5
172	R:R:F221	R:R:I220	3.77	No	No	0	4	4
173	R:R:L227	R:R:Y223	3.52	No	Yes	9	6	7
174	R:R:W286	R:R:Y223	6.75	Yes	Yes	9	9	7
175	R:R:F287	R:R:Y223	3.09	No	Yes	0	6	7
176	R:R:L294	R:R:Y223	11.72	No	Yes	0	6	7
177	R:R:P226	R:R:V225	3.53	No	No	0	9	5
178	R:R:L227	R:R:W286	6.83	No	Yes	9	6	9
179	R:R:I230	R:R:I283	4.42	No	No	0	8	8
180	R:R:F236	R:R:Y232	14.44	No	No	0	4	3
181	R:R:A279	R:R:Y234	4	No	Yes	0	7	9
182	R:R:T282	R:R:Y234	6.24	No	Yes	0	8	9
183	R:R:A276	R:R:V238	3.39	No	No	0	7	6
184	R:R:L275	R:R:V241	4.47	No	No	0	7	8
185	R:R:A242	R:R:E272	6.03	No	No	0	5	7
186	R:R:E245	R:R:R249	4.65	No	Yes	0	4	3
187	R:R:E250	R:R:K246	5.4	No	No	0	4	4
188	R:R:L248	R:R:L260	4.15	No	No	0	5	3
189	R:R:L248	R:R:R261	6.07	No	No	0	5	4
190	R:R:A269	R:R:R249	4.15	No	Yes	0	3	3
191	R:R:E264	R:R:N263	6.57	No	No	0	3	3
192	R:R:F273	R:R:K277	6.2	No	No	0	4	7
193	R:R:R274	R:R:V278	6.54	No	No	0	7	8
194	R:R:W286	R:R:W290	5.62	Yes	No	0	9	8
195	R:R:F287	R:R:T291	7.78	No	No	0	6	6
196	R:R:A289	R:R:S323	3.42	No	No	0	8	9
197	R:R:P292	R:R:T291	3.5	No	No	0	9	6
198	R:R:G316	R:R:P292	4.06	No	No	0	5	9
199	R:R:G316	R:R:Y293	4.35	No	Yes	0	5	6
200	R:R:A317	R:R:Y293	4	No	Yes	1	5	6
201	R:R:L296	R:R:S313	7.51	No	No	0	5	4
202	R:R:F298	R:R:F302	6.43	No	No	0	5	5
203	R:R:G300	R:R:R305	4.5	No	No	0	3	4
204	R:R:F302	R:R:I301	10.05	No	No	0	5	4
205	R:R:P310	R:R:T309	3.5	No	No	0	3	3
206	R:R:M311	R:R:T309	4.52	No	No	0	2	3
207	R:R:T309	R:R:T312	3.14	No	No	0	3	4
208	R:R:I318	R:R:W315	4.7	No	No	0	5	3
209	R:R:N327	R:R:S323	4.47	No	No	0	9	9
210	R:R:V330	R:R:Y326	6.31	No	No	0	8	5
211	R:R:N327	R:R:P328	3.26	No	No	0	9	9
212	R:R:V330	R:R:Y331	3.79	No	Yes	0	8	9
213	R:R:I333	R:R:R339	5.01	No	No	0	5	8
214	R:R:H335	R:R:Y338	8.71	No	Yes	0	8	8
215	R:R:K337	R:R:P336	6.69	No	No	0	6	5
216	R:R:I35	R:R:V24	3.07	No	No	0	7	6
217	R:R:I63	R:R:V59	3.07	No	No	0	5	4
218	R:R:I144	R:R:V89	3.07	No	No	0	9	7
219	R:R:I152	R:R:V151	3.07	No	No	0	8	8
220	R:R:M143	R:R:V173	3.04	No	No	0	6	6
221	R:R:F319	R:R:W315	3.01	No	No	0	7	3
222	R:R:L100	R:R:S64	3	No	No	0	6	8
223	R:R:L299	R:R:S303	3	Yes	No	0	4	3
224	R:R:L299	R:R:T295	2.95	Yes	No	0	4	6
225	R:R:I57	R:R:I60	2.94	Yes	No	0	7	7
226	R:R:I216	R:R:I220	2.94	No	No	0	4	4
227	R:R:I231	R:R:I283	2.94	No	No	0	5	8
228	R:R:I23	R:R:M197	2.92	No	No	0	6	3
229	R:R:D25	R:R:V24	2.92	No	No	0	8	6
230	R:R:I301	R:R:M212	2.92	No	No	0	4	1
231	R:R:I257	R:R:K258	2.91	No	No	0	4	5
232	R:R:G127	R:R:Y126	2.9	No	Yes	0	5	5
233	R:R:G127	R:R:Y191	2.9	No	Yes	0	5	4
234	R:R:L100	R:R:M104	2.83	No	Yes	0	6	7
235	R:R:L167	R:R:M170	2.83	No	No	0	1	7
236	R:R:E114	R:R:T47	2.82	No	No	0	3	2
237	R:R:D25	R:R:I21	2.8	No	No	0	8	4
238	R:R:K154	R:R:N150	2.8	No	No	0	5	4
239	R:R:E46	R:R:M49	2.71	No	No	0	4	4
240	R:R:K254	R:R:Q251	2.71	No	No	0	4	5
241	R:R:E250	R:R:K253	2.7	No	No	0	4	2
242	R:R:A320	R:R:Y293	2.67	No	Yes	0	7	6
243	R:R:F97	R:R:V65	2.62	Yes	No	0	6	6
244	R:R:A217	R:R:W180	2.59	No	No	0	4	5
245	R:R:A217	R:R:W188	2.59	No	Yes	0	4	6
246	R:R:F172	R:R:I175	2.51	No	No	0	3	4
247	R:R:T77	R:R:Y73	2.5	No	No	0	6	4
248	R:R:T106	R:R:Y126	2.5	No	Yes	0	6	5
249	R:R:M75	R:R:R82	2.48	No	No	0	7	8
250	R:R:M143	R:R:R169	2.48	No	No	0	6	4
251	R:R:S95	R:R:W174	2.47	No	No	0	8	9
252	R:R:E37	R:R:H36	2.46	No	No	0	5	7
253	R:R:V173	R:R:W139	2.45	No	Yes	0	6	5
254	R:R:F87	R:R:L167	2.44	No	No	0	5	1
255	R:R:F97	R:R:L94	2.44	Yes	No	0	6	6
256	R:R:F121	R:R:L125	2.44	No	No	0	1	5
257	R:R:F298	R:R:L299	2.44	No	Yes	0	5	4
258	R:R:T306	R:R:W307	2.43	No	No	0	3	3
259	R:R:E245	R:R:R261	2.33	No	No	0	4	4
260	R:R:F112	R:R:Y51	2.06	No	No	0	5	4
261	R:R:P43	R:R:P44	1.95	No	No	0	7	3
262	R:R:A166	R:R:P84	1.87	No	Yes	0	7	6
263	R:R:G134	R:R:S137	1.86	No	No	0	6	9
264	R:R:G67	R:R:V70	1.84	No	No	0	8	7
265	R:R:G165	R:R:V164	1.84	No	No	0	5	3
266	R:R:G85	R:R:T83	1.82	No	No	0	8	7
267	R:R:G54	R:R:I57	1.76	No	Yes	0	6	7
268	R:R:G119	R:R:I118	1.76	No	No	0	7	6
269	R:R:G179	R:R:I182	1.76	No	No	0	3	5
270	R:R:G69	R:R:M72	1.75	No	No	0	4	7
271	R:R:G134	R:R:M99	1.75	No	No	0	6	7
272	R:R:G158	R:R:K154	1.74	No	No	0	5	5
273	R:R:A136	R:R:S95	1.71	No	No	0	7	8
274	R:R:A136	R:R:S177	1.71	No	No	0	7	8
275	R:R:G165	R:R:L168	1.71	No	No	0	5	1
276	R:R:G179	R:R:L178	1.71	No	No	0	3	4
277	R:R:A252	R:R:S259	1.71	No	No	0	3	6
278	R:R:A93	R:R:V71	1.7	No	No	0	9	9
279	R:R:A341	R:R:V78	1.7	No	No	0	6	6
280	R:R:A279	R:R:V238	1.7	No	No	0	7	6
281	R:R:A113	R:R:T115	1.68	No	No	0	5	4
282	R:R:K159	R:R:P160	1.67	No	No	0	4	4
283	R:R:L26	R:R:P44	1.64	No	No	0	4	3
284	R:R:L32	R:R:P33	1.64	No	No	0	6	3
285	R:R:C325	R:R:I63	1.64	No	No	0	6	5
286	R:R:C233	R:R:L146	1.59	No	No	0	6	6
287	R:R:A341	R:R:L74	1.58	No	No	0	6	7
288	R:R:E29	R:R:P28	1.57	No	No	0	3	5
289	R:R:C285	R:R:N327	1.57	No	No	0	6	9
290	R:R:I109	R:R:S108	1.55	No	No	0	4	5
291	R:R:I301	R:R:S297	1.55	No	No	0	4	6
292	R:R:I62	R:R:V65	1.54	No	No	0	5	6
293	R:R:I237	R:R:V153	1.54	No	No	0	9	7
294	R:R:K345	R:R:V78	1.52	No	No	0	4	6
295	R:R:M212	R:R:T207	1.51	No	No	0	1	3
296	R:R:L74	R:R:V70	1.49	No	No	0	7	7
297	R:R:L275	R:R:V238	1.49	No	No	0	7	6
298	R:R:D304	R:R:T306	1.45	No	No	0	1	3
299	R:R:G332	R:R:Y338	1.45	No	Yes	0	6	8
300	R:R:K254	R:R:M255	1.44	No	No	0	4	4
301	R:R:I60	R:R:L56	1.43	No	No	0	7	3
302	R:R:E272	R:R:V241	1.43	No	No	0	7	8
303	R:R:E46	R:R:T47	1.41	No	No	0	4	2
304	L:L:?1	R:R:L215	1.39	Yes	No	0	0	5
305	R:R:H335	R:R:S334	1.39	No	No	0	8	7
306	R:R:L161	R:R:N150	1.37	No	No	0	5	4
307	R:R:R261	R:R:S259	1.32	No	No	0	4	6
308	R:R:F224	R:R:I220	1.26	No	No	0	4	4
309	R:R:F280	R:R:I283	1.26	No	No	0	5	8
310	R:R:D344	R:R:H343	1.26	No	No	0	4	4
311	R:R:K253	R:R:R249	1.24	No	Yes	0	2	3
312	R:R:E272	R:R:R249	1.16	No	Yes	0	7	3
313	R:R:L299	R:R:W307	1.14	Yes	No	0	4	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	6.0275	8	1	0
2	R:R:L27	5.975	4	2	4
3	R:R:M31	7.9275	4	2	6
4	R:R:H38	7.6225	4	5	8
5	R:R:W39	7.3075	4	0	6
6	R:R:F42	9.2125	4	5	5
7	R:R:I57	4.728	5	0	7
8	R:R:N68	5.4625	4	0	9
9	R:R:L81	5.456	5	7	8
10	R:R:P84	3.4125	4	0	6
11	R:R:F97	5.26	6	0	6
12	R:R:M104	4.838	5	6	7
13	R:R:W116	7.385	6	2	8
14	R:R:Y126	5.734	5	0	5
15	R:R:F133	6.2125	4	8	7
16	R:R:W139	5.4075	4	0	5
17	R:R:W188	10.176	5	0	6
18	R:R:Y191	6.215	4	0	4
19	R:R:P193	4.7725	4	2	3
20	R:R:E194	6.9825	4	1	4
21	R:R:S196	6.4325	4	3	4
22	R:R:T198	4.652	5	3	4
23	R:R:I205	7.6075	4	0	4
24	R:R:D206	7.1625	4	4	4
25	R:R:Y214	12.095	4	0	7
26	R:R:Y218	8.464	5	1	5
27	R:R:Y223	6.27	4	9	7
28	R:R:Y234	5.15	4	0	9
29	R:R:R249	2.8	4	0	3
30	R:R:W286	5.926	5	9	9
31	R:R:Y293	5.152	5	1	6
32	R:R:L299	2.3825	4	0	4
33	R:R:Y331	4.575	4	0	9
34	R:R:Y338	6.0375	4	7	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y293	67.3253	3.52	Yes	Yes	1	0	6
2	R:R:E194	R:R:Y293	65.5709	11.22	Yes	Yes	1	4	6
3	R:R:E194	R:R:Y204	55.1883	6.73	Yes	No	1	4	5
4	R:R:I205	R:R:Y204	60.1641	3.63	Yes	No	0	4	5
5	R:R:H36	R:R:I205	60.3018	13.26	No	Yes	0	7	4
6	R:R:D206	R:R:H36	58.3259	8.82	Yes	No	0	4	7
7	R:R:D203	R:R:D206	75.1871	10.65	No	Yes	4	2	4
8	R:R:D203	R:R:V192	74.0914	16.07	No	No	0	2	1
9	R:R:P193	R:R:V192	72.7082	3.53	Yes	No	0	3	1
10	R:R:I35	R:R:P193	18.436	5.08	No	Yes	2	7	3
11	R:R:I35	R:R:V24	18.0768	3.07	No	No	0	7	6
12	R:R:D25	R:R:V24	10.9874	2.92	No	No	0	8	6
13	R:R:M31	R:R:P193	31.5131	6.71	Yes	Yes	2	6	3
14	R:R:L27	R:R:M31	13.8375	11.31	Yes	Yes	2	4	6
15	R:R:M31	R:R:W116	17.4481	3.49	Yes	Yes	2	6	8
16	R:R:C200	R:R:P193	21.7592	3.77	No	Yes	2	9	3
17	R:R:C200	R:R:W116	16.6936	5.22	No	Yes	2	9	8
18	R:R:I118	R:R:W116	27.7289	11.74	No	Yes	0	6	8
19	R:R:G119	R:R:I118	10.4844	1.76	No	No	0	7	6
20	R:R:I205	R:R:W39	13.4603	3.52	Yes	Yes	0	4	6
21	R:R:F42	R:R:W39	12.3406	7.02	Yes	Yes	0	5	6
22	L:L:?1	R:R:M103	55.326	5.66	Yes	No	0	0	7
23	R:R:M103	R:R:Y126	29.3216	9.58	No	Yes	0	7	5
24	R:R:M107	R:R:Y126	26.3817	4.79	No	Yes	0	7	5
25	R:R:M107	R:R:T198	39.8479	4.52	No	Yes	0	7	4
26	R:R:S196	R:R:T198	16.7655	4.8	Yes	Yes	3	4	4
27	R:R:P310	R:R:S196	15.7056	3.56	No	Yes	0	3	4
28	L:L:?1	R:R:K321	40.752	12.71	Yes	No	0	0	7
29	R:R:I57	R:R:K321	39.5485	5.82	Yes	No	0	7	7
30	R:R:I57	R:R:M107	22.8429	7.29	Yes	No	0	7	7
31	R:R:H50	R:R:T198	15.0111	4.11	No	Yes	3	5	4
32	R:R:E114	R:R:H50	12.5681	20.92	No	No	0	3	5
33	R:R:E114	R:R:T47	10.0772	2.82	No	No	0	3	2
34	R:R:T198	R:R:V314	10.3826	4.76	Yes	No	3	4	4
35	R:R:L53	R:R:V314	10.173	5.96	No	No	0	5	4
36	R:R:I57	R:R:M104	23.3459	5.83	Yes	Yes	0	7	7
37	R:R:L100	R:R:M104	11.0233	2.83	No	Yes	0	6	7
38	L:L:?1	R:R:W290	100	14.83	Yes	No	0	0	8
39	R:R:W286	R:R:W290	99.1797	5.62	Yes	No	0	9	8
40	R:R:L141	R:R:W286	97.3774	4.56	No	Yes	0	8	9
41	R:R:L141	R:R:Y331	96.4613	3.52	No	Yes	0	8	9
42	R:R:V89	R:R:Y331	52.3921	3.79	No	Yes	0	7	9
43	R:R:I144	R:R:V89	51.0448	3.07	No	No	0	9	7
44	R:R:I144	R:R:L88	49.6976	5.71	No	No	0	9	7
45	R:R:D147	R:R:L88	48.3504	4.07	No	No	0	8	7
46	R:R:D147	R:R:L161	47.0032	6.79	No	No	0	8	5
47	R:R:L161	R:R:P84	41.5424	4.93	No	Yes	0	5	6
48	R:R:P84	R:R:T83	39.7282	3.5	Yes	No	0	6	7
49	R:R:N86	R:R:T83	36.1715	13.16	No	No	0	9	7
50	R:R:L81	R:R:N86	26.7349	6.87	Yes	No	7	8	9
51	R:R:L81	R:R:V78	19.5737	5.96	Yes	No	0	8	6
52	R:R:A341	R:R:V78	11.8855	1.7	No	No	0	6	6
53	R:R:M103	R:R:M99	40.3748	8.66	No	No	0	7	7
54	R:R:F133	R:R:M99	35.7044	9.95	Yes	No	0	7	7
55	R:R:F133	R:R:G98	29.112	4.52	Yes	No	0	7	7
56	R:R:F97	R:R:G98	27.4954	4.52	Yes	No	0	6	7
57	R:R:F97	R:R:N68	17.7175	3.62	Yes	Yes	0	6	9
58	L:L:?1	R:R:Y218	42.9256	3.52	Yes	Yes	1	0	5
59	R:R:S135	R:R:Y218	25.3338	6.36	No	Yes	1	5	5
60	R:R:S135	R:R:S177	25.7889	6.52	No	No	0	5	8
61	R:R:A136	R:R:S177	24.4297	1.71	No	No	0	7	8
62	R:R:A136	R:R:S95	23.0705	1.71	No	No	0	7	8
63	R:R:S95	R:R:W174	21.7113	2.47	No	No	0	8	9
64	R:R:N91	R:R:W174	20.3521	4.52	No	No	0	9	9
65	R:R:M170	R:R:N91	16.9211	8.41	No	No	0	7	9
66	R:R:L167	R:R:M170	15.9931	2.83	No	No	0	1	7
67	R:R:F87	R:R:L167	15.0949	2.44	No	No	0	5	1
68	R:R:F87	R:R:K163	10.7838	6.2	No	No	0	5	2
69	R:R:K163	R:R:P84	10.694	3.35	No	Yes	0	2	6
70	R:R:I118	R:R:M122	13.9572	8.75	No	No	0	6	5
71	R:R:L125	R:R:M122	10.4844	4.24	No	No	0	5	5
72	R:R:S131	R:R:Y218	11.9334	10.17	No	Yes	0	4	5
73	R:R:S131	R:R:T181	10.1251	6.4	No	No	0	4	7
74	R:R:G127	R:R:Y126	10.2329	2.9	No	Yes	0	5	5
75	R:R:G127	R:R:Y191	10.1431	2.9	No	Yes	0	5	4
76	R:R:L132	R:R:T181	11.1071	5.9	No	No	0	4	7
77	R:R:V222	R:R:Y218	11.0892	12.62	No	Yes	1	5	5
78	R:R:V222	R:R:W139	11.1909	6.13	No	Yes	0	5	5
79	R:R:R148	R:R:Y331	59.4156	7.2	No	Yes	0	9	9
80	R:R:R148	R:R:Y234	57.9726	4.12	No	Yes	0	9	9
81	R:R:T145	R:R:Y234	26.6691	6.24	No	Yes	0	8	9
82	R:R:C233	R:R:T145	18.0768	3.38	No	No	0	6	8
83	R:R:C233	R:R:Y149	14.556	9.41	No	No	0	6	8
84	R:R:W180	R:R:Y218	27.9504	9.65	No	Yes	0	5	5
85	R:R:A217	R:R:W180	21.9628	2.59	No	No	0	4	5
86	R:R:A217	R:R:W188	21.0526	2.59	No	Yes	0	4	6
87	R:R:W188	R:R:Y214	12.7837	22.19	Yes	Yes	0	6	7
88	R:R:N210	R:R:W188	24.9925	13.56	No	Yes	0	3	6
89	R:R:N210	R:R:P211	23.801	4.89	No	No	0	3	5
90	L:L:?1	R:R:L215	23.0465	1.39	Yes	No	0	0	5
91	R:R:L215	R:R:S297	21.4059	6.01	No	No	0	5	6
92	R:R:A279	R:R:Y234	31.6089	4	No	Yes	0	7	9
93	R:R:A279	R:R:V238	29.9503	1.7	No	No	0	7	6
94	R:R:L275	R:R:V238	26.5912	1.49	No	No	0	7	6
95	R:R:L275	R:R:V241	24.8907	4.47	No	No	0	7	8
96	R:R:E272	R:R:V241	23.1783	1.43	No	No	0	7	8
97	R:R:E272	R:R:R249	19.7234	1.16	No	Yes	0	7	3
98	R:R:E245	R:R:R249	10.9095	4.65	No	Yes	0	4	3
99	R:R:I301	R:R:S297	19.6874	1.55	No	No	0	4	6
100	R:R:F302	R:R:I301	14.4602	10.05	No	No	0	5	4
101	R:R:F298	R:R:F302	12.6939	6.43	No	No	0	5	5
102	R:R:F298	R:R:L299	10.9155	2.44	No	Yes	0	5	4
103	R:R:F42	R:R:P310	10.0533	5.78	Yes	No	0	5	3
104	R:R:I202	R:R:Y191	10.5563	4.84	No	Yes	0	5	4
105	R:R:D206	R:R:P211	22.1124	3.22	Yes	No	0	4	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:M103	5.66	1	Yes	No	0	7	0	1
L:L:?1	R:R:G130	3.43	1	Yes	No	0	6	0	1
L:L:?1	R:R:Y218	3.52	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:W290	14.83	1	Yes	No	0	8	0	1
L:L:?1	R:R:Y293	3.52	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:A317	3.16	1	Yes	No	0	5	0	1
L:L:?1	R:R:K321	12.71	1	Yes	No	0	7	0	1
R:R:I57	R:R:K321	5.82	0	Yes	No	7	7	2	1
R:R:M103	R:R:M99	8.66	0	No	No	7	7	1	2
R:R:M103	R:R:Y126	9.58	0	No	Yes	7	5	1	2
R:R:S131	R:R:Y218	10.17	0	No	Yes	4	5	2	1
R:R:S135	R:R:Y218	6.36	1	No	Yes	5	5	2	1
R:R:S135	R:R:V222	3.23	1	No	No	5	5	2	2
R:R:W180	R:R:Y218	9.65	0	No	Yes	5	5	2	1
R:R:E194	R:R:Y293	11.22	1	Yes	Yes	4	6	2	1
R:R:L215	R:R:S297	6.01	0	No	No	5	6	1	2
R:R:V222	R:R:Y218	12.62	1	No	Yes	5	5	2	1
R:R:W286	R:R:W290	5.62	9	Yes	No	9	8	2	1
R:R:G316	R:R:Y293	4.35	0	No	Yes	5	6	2	1
R:R:A317	R:R:Y293	4	1	No	Yes	5	6	1	1
R:R:A320	R:R:Y293	2.67	0	No	Yes	7	6	2	1
L:L:?1	R:R:L215	1.39	1	Yes	No	0	5	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9EPP_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.09
Number of Linked Nodes	295
Number of Links	313
Number of Hubs	34
Number of Links mediated by Hubs	137
Number of Communities	9
Number of Nodes involved in Communities	39
Number of Links involved in Communities	45

Path Summary
Number Of Nodes in MetaPath	106
Number Of Links MetaPath	105
Number of Shortest Paths	46480
Length Of Smallest Path	3
Average Path Length	14.6533
Length of Longest Path	36
Minimum Path Strength	1.2
Average Path Strength	6.14842
Maximum Path Strength	17.875
Minimum Path Correlation	0.7
Average Path Correlation	0.950598
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	61.6947
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	35.7858
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• multicellular organismal process • sensory perception of light stimulus • system process • sensory perception • nervous system process • visual perception • phototransduction • cellular response to stimulus • detection of light stimulus • response to light stimulus • detection of external stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • response to external stimulus • detection of abiotic stimulus • cell communication • detection of stimulus • cellular process • response to abiotic stimulus • response to radiation • signal transduction • cellular anatomical structure • membrane • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • G protein-coupled receptor signaling pathway • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • cell projection • sperm principal piece • cilium • 9+2 motile cilium • sperm flagellum • motile cilium • plasma membrane bounded cell projection • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • ciliary basal body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	B1B1U5
Sequence	>9EPP_nogp_Chain_R N I S I V D L L P E D M L P M I H E H W Y K F P P M E T S M H Y I L G M L I I V I G I I S V S G N G V V M Y L M M T V K N L R T P G N F L V L N L A L S D F G M L F F M M P T M S I N C F A E T W V I G P F M C E L Y G M I G S L F G S A S I W S L V M I T L D R Y N V I V K G M A G K P L T K V G A L L R M L F V W I W S L G W T I A P M Y G W S R Y V P E G S M T S C T I D Y I D T A I N P M S Y L I A Y A I F V Y F V P L F I I I Y C Y A F I V M Q V A A H E K S L R E Q A K K M N I K S L R S N E A S A E F R L A K V A F M T I C C W F M A W T P Y L T L S F L G I F S D R T W L T P M T S V W G A I F A K A S A C Y N P I V Y G I S H P K Y R A A L H D K F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	1F88	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.8	2000-08-04	doi.org/10.1126/science.289.5480.739
	1HZX	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.8	2001-07-04	doi.org/10.1021/bi0155091
	1L9H	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.6	2002-05-15	doi.org/10.1073/pnas.082666399
	1GZM	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.65	2003-11-20	doi.org/10.1016/j.jmb.2004.08.090
	1U19	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.2	2004-10-12	doi.org/10.1016/j.jmb.2004.07.044
	2HPY	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	2.8	2006-08-22	doi.org/10.1073/pnas.0601765103
	2G87	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	2.6	2006-09-02	doi.org/10.1002/anie.200600595
	2I35	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	3.8	2006-10-17	doi.org/10.1073/pnas.0608022103
	2I36	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.1	2006-10-17	doi.org/10.1073/pnas.0608022103
	2I37	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.15	2006-10-17	doi.org/10.1073/pnas.0608022103
	2J4Y	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	3.4	2007-09-25	doi.org/10.1016/j.jmb.2007.03.007
	2PED	A	Sensory	Opsins	Rhodopsin	Bos taurus	9-cis-Retinal	-	-	2.95	2007-10-30	doi.org/10.1529/biophysj.107.108225
	2ZIY	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	11-cis-Retinal	-	-	3.7	2008-05-06	doi.org/10.1074/jbc.C800040200
	2Z73	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	11-cis-Retinal	-	-	2.5	2008-05-13	doi.org/10.1038/nature06925
	3CAP	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	2.9	2008-06-24	doi.org/10.1038/nature07063
	3C9L	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.65	2008-08-05	doi.org/10.1107/S0907444908017162
	3C9M	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	3.4	2008-08-05	doi.org/10.1107/S0907444908017162
	3DQB	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gt(CT)	3.2	2008-09-23	doi.org/10.1038/nature07330
	3DQB (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		3.2	2008-09-23	doi.org/10.1038/nature07330
	3OAX	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	2.6	2011-01-19	doi.org/10.1016/j.bpj.2010.08.003
	3PQR	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	2.85	2011-03-09	doi.org/10.1038/nature09789
	3PQR (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		2.85	2011-03-09	doi.org/10.1038/nature09789
	3PXO	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	3	2011-03-09	doi.org/10.1038/nature09789
	2X72	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	3	2011-03-16	doi.org/10.1038/nature09795
	2X72 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3	2011-03-16	doi.org/10.1038/nature09795
	3AYM	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	All-trans-Retinal	-	-	2.8	2011-08-17	doi.org/10.1016/j.jmb.2011.08.044
	3AYN	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	9-cis-Retinal	-	-	2.7	2011-08-17	doi.org/10.1016/j.jmb.2011.08.044
	4A4M	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	3.3	2012-01-25	doi.org/10.1073/pnas.1114089108
	4A4M (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3.3	2012-01-25	doi.org/10.1073/pnas.1114089108
	4BEZ	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	3.3	2013-04-24	doi.org/10.1038/embor.2013.44
	4BEY	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gt(CT)	2.9	2013-05-08	doi.org/10.1038/embor.2013.44
	4BEY (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		2.9	2013-05-08	doi.org/10.1038/embor.2013.44
	4J4Q	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl β-D-Glucopyranoside	-	Gt(CT)	2.65	2013-10-30	doi.org/10.1002/anie.201302374
	4J4Q (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl β-D-Glucopyranoside	-		2.65	2013-10-30	doi.org/10.1002/anie.201302374
	4PXF	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Arrestin1 Finger Loop	2.75	2014-09-17	doi.org/10.1038/ncomms5801
	4WW3	A	Sensory	Opsins	Rhodopsin	Todarodes pacificus	All-trans-Retinal	-	-	2.8	2015-06-17	doi.org/10.1371/journal.pone.0126970
	4ZWJ	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-	Arrestin1	3.3	2015-07-29	doi.org/10.1038/nature14656
	4X1H	A	Sensory	Opsins	Rhodopsin	Bos taurus	Nonyl-β-D-Glucopyranoside	-	Gt(CT)	2.29	2015-11-04	doi.org/10.1016/j.str.2015.09.015
	4X1H (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	Nonyl-β-D-Glucopyranoside	-		2.29	2015-11-04	doi.org/10.1016/j.str.2015.09.015
	5DGY	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-	Arrestin1	7.7	2016-03-23	doi.org/10.1038/sdata.2016.21
	5DYS	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	2.3	2016-08-10	doi.org/10.15252/embr.201642671
	5EN0	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt(CT)	2.81	2016-08-10	doi.org/10.15252/embr.201642671
	5EN0 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		2.81	2016-08-10	doi.org/10.15252/embr.201642671
	5TE3	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	-	2.7	2017-03-15	doi.org/10.1073/pnas.1617446114
	5TE5	A	Sensory	Opsins	Rhodopsin	Bos taurus	20-Methanoretinal	-	-	4.01	2017-03-15	doi.org/10.1073/pnas.1617446114
	5W0P	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-	Arrestin1	3.01	2017-08-09	doi.org/10.1016/j.cell.2017.07.002
	5WKT	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Gt(CT)	3.2	2017-12-13	doi.org/10.1038/nprot.2017.135
	5WKT (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-		3.2	2017-12-13	doi.org/10.1038/nprot.2017.135
	6FK6	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473033	-	2.36	2018-04-04	doi.org/10.1073/pnas.1718084115
	6FK7	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473034	-	2.62	2018-04-04	doi.org/10.1073/pnas.1718084115
	6FK8	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473035	-	2.87	2018-04-04	doi.org/10.1073/pnas.1718084115
	6FK9	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473036	-	2.63	2018-04-04	doi.org/10.1073/pnas.1718084115
	6FKA	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473037	-	2.7	2018-04-04	doi.org/10.1073/pnas.1718084115
	6FKB	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473038	-	3.03	2018-04-04	doi.org/10.1073/pnas.1718084115
	6FKC	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 132473039	-	2.46	2018-04-04	doi.org/10.1073/pnas.1718084115
	6FKD	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	PubChem 137349183	-	2.49	2018-04-04	doi.org/10.1073/pnas.1718084115
	6CMO	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-	Gi1/β1/γ2	4.5	2018-06-20	doi.org/10.1038/s41586-018-0215-y
	6CMO (No Gprot)	A	Sensory	Opsins	Rhodopsin	Homo sapiens	-	-		4.5	2018-06-20	doi.org/10.1038/s41586-018-0215-y
	6FUF	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Go	3.12	2018-10-03	doi.org/10.1126/sciadv.aat7052
	6FUF (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3.12	2018-10-03	doi.org/10.1126/sciadv.aat7052
	6I9K	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	9-cis-Retinal	-	-	2.15	2019-07-03	doi.org/10.1073/pnas.1902192116
	6QNO	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gi1/β1/γ1	4.38	2019-07-10	doi.org/10.7554/eLife.46041
	6QNO (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		4.38	2019-07-10	doi.org/10.7554/eLife.46041
	6OY9	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt/β1/γ1	3.9	2019-07-24	doi.org/10.1016/j.molcel.2019.06.007
	6OY9 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3.9	2019-07-24	doi.org/10.1016/j.molcel.2019.06.007
	6OYA	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	Gt/β1/γ1	3.3	2019-07-24	doi.org/10.1016/j.molcel.2019.06.007
	6OYA (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-		3.3	2019-07-24	doi.org/10.1016/j.molcel.2019.06.007
	6OFJ	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.5	2019-08-21	doi.org/10.1074/jbc.RA119.010089
	6NWE	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-	Gt(CT)	2.71	2020-02-12	To be published
	6NWE (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	Octyl-β-D-Glucopyranoside	-		2.71	2020-02-12	To be published
	6PEL	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Citronellol	Gt(CT)	3.19	2020-06-24	To be published
	6PEL (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Citronellol		3.19	2020-06-24	To be published
	6PGS	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Geraniol	Gt(CT)	2.9	2020-07-01	To be published
	6PGS (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Geraniol		2.9	2020-07-01	To be published
	6PH7	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Nerol	Gt(CT)	2.9	2020-07-01	To be published
	6PH7 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	Nerol		2.9	2020-07-01	To be published
	7MT8	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	GRK1	5.8	2021-07-07	doi.org/10.1038/s41586-021-03721-x
	7MT9	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	GRK1	7	2021-07-07	doi.org/10.1038/s41586-021-03721-x
	7MTA	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	GRK1	4.1	2021-07-07	doi.org/10.1038/s41586-021-03721-x
	7MTB	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	GRK1	4	2021-07-07	doi.org/10.1038/s41586-021-03721-x
	7ZBC	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	1.8	2023-03-29	doi.org/10.1038/s41586-023-05863-6
	7ZBE	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	1.8	2023-03-29	doi.org/10.1038/s41586-023-05863-6
	8A6C	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	1.8	2023-03-29	doi.org/10.1038/s41586-023-05863-6
	8A6D	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	1.8	2023-03-29	doi.org/10.1038/s41586-023-05863-6
	8A6E	A	Sensory	Opsins	Rhodopsin	Bos taurus	All-trans-Retinal	-	-	1.8	2023-03-29	doi.org/10.1038/s41586-023-05863-6
	8FCZ	A	Sensory	Opsins	Rhodopsin	Bos taurus	11-cis-Retinal	-	-	3.7	2023-08-30	doi.org/10.1038/s41467-023-40911-9
	8FD0	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	3.71	2023-08-30	doi.org/10.1038/s41467-023-40911-9
	8FD1	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	-	4.25	2023-08-30	doi.org/10.1038/s41467-023-40911-9
	9EPP	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	11,20-Ethanoretinal	-	chim(Gi1-CtGq)/β1/γ2	4.06	2024-10-23	doi.org/10.1038/s41467-024-53208-2
	9EPP (No Gprot)	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	11,20-Ethanoretinal	-		4.06	2024-10-23	doi.org/10.1038/s41467-024-53208-2
	9EPQ	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	11,20-Ethanoretinal	-	chim(Gi1-CtGq)/β1/γ2	4.15	2024-10-23	doi.org/10.1038/s41467-024-53208-2
	9EPQ (No Gprot)	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	11,20-Ethanoretinal	-		4.15	2024-10-23	doi.org/10.1038/s41467-024-53208-2
	9EPR	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	All-trans-Retinal	-	Gi1/β1/γ2	4.9	2024-10-30	doi.org/10.1038/s41467-024-53208-2
	9EPR (No Gprot)	A	Sensory	Opsins	Rhodopsin	Hasarius adansoni	All-trans-Retinal	-		4.9	2024-10-30	doi.org/10.1038/s41467-024-53208-2
	8P12	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gi1/β1/γT1	3.21	2024-11-20	To be published
	8P12 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		3.21	2024-11-20	To be published
	8P13	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gi1/β1/γT1	5.2	2024-11-20	To be published
	8P13 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		5.2	2024-11-20	To be published
	8P15	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-	Gi1/β1/γT1	5.9	2024-11-20	To be published
	8P15 (No Gprot)	A	Sensory	Opsins	Rhodopsin	Bos taurus	-	-		5.9	2024-11-20	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9EPP_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.