| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 5W0P | A | Sensory | Opsins | Rhodopsin | Homo Sapiens | - | - | Arrestin1 | 3.01 | 2017-08-09 | doi.org/10.1016/j.cell.2017.07.002 |
|
A 2D representation of the interactions of SEP in 5W0P
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?336 | R:R:V337 | 7.33 | 0 | Yes | No | 6 | 5 | 2 | 1 | | R:R:?336 | V:V:K16 | 15.02 | 0 | Yes | No | 6 | 9 | 2 | 1 | | R:R:?338 | R:R:V337 | 8.84 | 9 | Yes | No | 8 | 5 | 0 | 1 | | R:R:K339 | R:R:V337 | 4.55 | 9 | No | No | 5 | 5 | 1 | 1 | | R:R:?338 | R:R:K339 | 7.18 | 9 | Yes | No | 8 | 5 | 0 | 1 | | R:R:?338 | V:V:K16 | 4.78 | 9 | Yes | No | 8 | 9 | 0 | 1 | | R:R:?338 | V:V:R30 | 8.24 | 9 | Yes | Yes | 8 | 9 | 0 | 1 | | R:R:?338 | V:V:K301 | 8.37 | 9 | Yes | No | 8 | 9 | 0 | 1 | | V:V:F14 | V:V:R30 | 7.48 | 9 | No | Yes | 6 | 9 | 2 | 1 | | V:V:F14 | V:V:L173 | 3.65 | 9 | No | No | 6 | 8 | 2 | 2 | | V:V:K16 | V:V:V171 | 6.07 | 0 | No | Yes | 9 | 7 | 1 | 2 | | V:V:L173 | V:V:R30 | 6.07 | 9 | No | Yes | 8 | 9 | 2 | 1 | | V:V:I300 | V:V:R30 | 7.52 | 0 | No | Yes | 7 | 9 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 5.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 7.48 | | Average Nodes In Shell | 11.00 | | Average Hubs In Shell | 4.00 | | Average Links In Shell | 13.00 | | Average Links Mediated by Hubs In Shell | 11.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 6TKO | A | Amine | Adrenergic | Beta1 | Meleagris Gallopavo | Arformoterol | - | Arrestin2 | 3.3 | 2020-06-17 | doi.org/10.1038/s41586-020-2419-1 |
|
A 2D representation of the interactions of SEP in 6TKO
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?360 | V:V:K11 | 5.98 | 0 | Yes | Yes | 3 | 9 | 0 | 1 | | R:R:?360 | V:V:R165 | 6.18 | 0 | Yes | Yes | 3 | 5 | 0 | 1 | | R:R:?363 | V:V:K11 | 19.65 | 11 | Yes | Yes | 4 | 9 | 2 | 1 | | R:R:?363 | V:V:L166 | 5.67 | 11 | Yes | Yes | 4 | 8 | 2 | 2 | | V:V:K11 | V:V:V164 | 4.55 | 11 | Yes | No | 9 | 8 | 1 | 2 | | V:V:K11 | V:V:L166 | 9.87 | 11 | Yes | Yes | 9 | 8 | 1 | 2 | | V:V:E145 | V:V:K147 | 16.2 | 9 | Yes | Yes | 7 | 7 | 2 | 2 | | V:V:E145 | V:V:R165 | 5.82 | 9 | Yes | Yes | 7 | 5 | 2 | 1 | | V:V:K147 | V:V:R165 | 8.66 | 9 | Yes | Yes | 7 | 5 | 2 | 1 | | R:R:?360 | R:R:E359 | 3.37 | 0 | Yes | No | 3 | 7 | 0 | 1 | | R:R:?360 | R:R:A361 | 2.67 | 0 | Yes | No | 3 | 5 | 0 | 1 | | V:V:K160 | V:V:R165 | 2.48 | 0 | No | Yes | 8 | 5 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 4.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 4.55 | | Average Nodes In Shell | 11.00 | | Average Hubs In Shell | 7.00 | | Average Links In Shell | 12.00 | | Average Links Mediated by Hubs In Shell | 12.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of SEP in 6TKO
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?365 | R:R:?366 | 15.93 | 3 | Yes | Yes | 4 | 8 | 0 | 1 | | R:R:?365 | V:V:R7 | 14.42 | 3 | Yes | No | 4 | 4 | 0 | 1 | | R:R:?365 | V:V:K10 | 11.96 | 3 | Yes | No | 4 | 9 | 0 | 1 | | R:R:?366 | R:R:?367 | 34.85 | 3 | Yes | No | 8 | 3 | 1 | 2 | | R:R:?366 | V:V:R7 | 12.36 | 3 | Yes | No | 8 | 4 | 1 | 1 | | R:R:?366 | V:V:V8 | 7.58 | 3 | Yes | Yes | 8 | 7 | 1 | 2 | | R:R:?366 | V:V:K10 | 17.94 | 3 | Yes | No | 8 | 9 | 1 | 1 | | R:R:?366 | V:V:K107 | 7.18 | 3 | Yes | No | 8 | 9 | 1 | 2 | | R:R:?367 | V:V:R7 | 10.3 | 3 | No | No | 3 | 4 | 2 | 1 | | R:R:?367 | V:V:K107 | 9.57 | 3 | No | No | 3 | 9 | 2 | 2 | | V:V:V8 | V:V:Y21 | 3.79 | 3 | Yes | Yes | 7 | 8 | 2 | 2 | | V:V:K10 | V:V:Y21 | 15.53 | 3 | No | Yes | 9 | 8 | 1 | 2 | | R:R:?365 | R:R:A364 | 2.67 | 3 | Yes | No | 4 | 2 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 4.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 11.25 | | Average Nodes In Shell | 9.00 | | Average Hubs In Shell | 4.00 | | Average Links In Shell | 13.00 | | Average Links Mediated by Hubs In Shell | 11.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of SEP in 6TKO
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?365 | R:R:?366 | 15.93 | 3 | Yes | Yes | 4 | 8 | 1 | 0 | | R:R:?365 | V:V:R7 | 14.42 | 3 | Yes | No | 4 | 4 | 1 | 1 | | R:R:?365 | V:V:K10 | 11.96 | 3 | Yes | No | 4 | 9 | 1 | 1 | | R:R:?366 | R:R:?367 | 34.85 | 3 | Yes | No | 8 | 3 | 0 | 1 | | R:R:?366 | V:V:R7 | 12.36 | 3 | Yes | No | 8 | 4 | 0 | 1 | | R:R:?366 | V:V:V8 | 7.58 | 3 | Yes | Yes | 8 | 7 | 0 | 1 | | R:R:?366 | V:V:K10 | 17.94 | 3 | Yes | No | 8 | 9 | 0 | 1 | | R:R:?366 | V:V:K107 | 7.18 | 3 | Yes | No | 8 | 9 | 0 | 1 | | R:R:?367 | V:V:R7 | 10.3 | 3 | No | No | 3 | 4 | 1 | 1 | | R:R:?367 | V:V:K107 | 9.57 | 3 | No | No | 3 | 9 | 1 | 1 | | R:R:L368 | V:V:V8 | 4.47 | 3 | No | Yes | 3 | 7 | 2 | 1 | | V:V:V8 | V:V:Y21 | 3.79 | 3 | Yes | Yes | 7 | 8 | 1 | 2 | | V:V:L104 | V:V:V8 | 7.45 | 3 | Yes | Yes | 9 | 7 | 2 | 1 | | V:V:K10 | V:V:Y21 | 15.53 | 3 | No | Yes | 9 | 8 | 1 | 2 | | V:V:L104 | V:V:Y21 | 7.03 | 3 | Yes | Yes | 9 | 8 | 2 | 2 | | V:V:L108 | V:V:Y21 | 11.72 | 0 | Yes | Yes | 8 | 8 | 2 | 2 | | V:V:K107 | V:V:L108 | 5.64 | 3 | No | Yes | 9 | 8 | 1 | 2 | | R:R:?365 | R:R:A364 | 2.67 | 3 | Yes | No | 4 | 2 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 6.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 15.97 | | Average Nodes In Shell | 12.00 | | Average Hubs In Shell | 6.00 | | Average Links In Shell | 18.00 | | Average Links Mediated by Hubs In Shell | 16.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of SEP in 6TKO
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?365 | R:R:?366 | 15.93 | 3 | Yes | Yes | 4 | 8 | 2 | 1 | | R:R:?365 | V:V:R7 | 14.42 | 3 | Yes | No | 4 | 4 | 2 | 1 | | R:R:?365 | V:V:K10 | 11.96 | 3 | Yes | No | 4 | 9 | 2 | 2 | | R:R:?366 | R:R:?367 | 34.85 | 3 | Yes | No | 8 | 3 | 1 | 0 | | R:R:?366 | V:V:R7 | 12.36 | 3 | Yes | No | 8 | 4 | 1 | 1 | | R:R:?366 | V:V:V8 | 7.58 | 3 | Yes | Yes | 8 | 7 | 1 | 2 | | R:R:?366 | V:V:K10 | 17.94 | 3 | Yes | No | 8 | 9 | 1 | 2 | | R:R:?366 | V:V:K107 | 7.18 | 3 | Yes | No | 8 | 9 | 1 | 1 | | R:R:?367 | V:V:R7 | 10.3 | 3 | No | No | 3 | 4 | 0 | 1 | | R:R:?367 | V:V:K107 | 9.57 | 3 | No | No | 3 | 9 | 0 | 1 | | V:V:K107 | V:V:L108 | 5.64 | 3 | No | Yes | 9 | 8 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 18.24 | | Average Nodes In Shell | 8.00 | | Average Hubs In Shell | 4.00 | | Average Links In Shell | 11.00 | | Average Links Mediated by Hubs In Shell | 9.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7E9H | C | Aminoacid | Metabotropic Glutamate | mGlu4; mGlu4 | Homo Sapiens | Phosphoserine | - | Gi3/Beta1/Gamma2 | 4 | 2021-06-23 | doi.org/10.1038/s41586-021-03495-2 |
|
A 2D representation of the interactions of SEP in 7E9H
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | L:L:?1001 | R:R:K74 | 15.55 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | | L:L:?1001 | R:R:R78 | 6.18 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | | L:L:?1001 | R:R:S157 | 5.09 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | | L:L:?1001 | R:R:G158 | 4.35 | 2 | Yes | No | 0 | 4 | 0 | 1 | | L:L:?1001 | R:R:S159 | 7.64 | 2 | Yes | Yes | 0 | 9 | 0 | 1 | | L:L:?1001 | R:R:T182 | 3.75 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | | L:L:?1001 | R:R:Y230 | 25.85 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | | L:L:?1001 | R:R:S313 | 3.82 | 2 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1001 | R:R:K405 | 3.59 | 2 | Yes | Yes | 0 | 4 | 0 | 1 | | R:R:K71 | R:R:P56 | 3.35 | 2 | Yes | Yes | 5 | 5 | 2 | 2 | | R:R:K74 | R:R:P56 | 3.35 | 2 | Yes | Yes | 5 | 5 | 1 | 2 | | R:R:P56 | R:R:S157 | 7.13 | 2 | Yes | Yes | 5 | 5 | 2 | 1 | | R:R:K71 | R:R:K74 | 17.24 | 2 | Yes | Yes | 5 | 5 | 2 | 1 | | R:R:K74 | R:R:R78 | 8.66 | 2 | Yes | Yes | 5 | 4 | 1 | 1 | | R:R:E287 | R:R:K74 | 10.8 | 2 | Yes | Yes | 3 | 5 | 2 | 1 | | R:R:R78 | R:R:S157 | 10.54 | 2 | Yes | Yes | 4 | 5 | 1 | 1 | | R:R:R78 | R:R:Y179 | 10.29 | 2 | Yes | Yes | 4 | 8 | 1 | 2 | | R:R:A180 | R:R:R78 | 4.15 | 2 | No | Yes | 6 | 4 | 2 | 1 | | R:R:E403 | R:R:R78 | 10.47 | 2 | No | Yes | 5 | 4 | 2 | 1 | | R:R:K405 | R:R:R78 | 14.85 | 2 | Yes | Yes | 4 | 4 | 1 | 1 | | R:R:S157 | R:R:Y179 | 6.36 | 2 | Yes | Yes | 5 | 8 | 1 | 2 | | R:R:S159 | R:R:S181 | 4.89 | 2 | Yes | No | 9 | 8 | 1 | 2 | | R:R:A183 | R:R:S159 | 3.42 | 0 | No | Yes | 7 | 9 | 2 | 1 | | R:R:S159 | R:R:Y230 | 6.36 | 2 | Yes | Yes | 9 | 7 | 1 | 1 | | R:R:A180 | R:R:K405 | 4.82 | 2 | No | Yes | 6 | 4 | 2 | 1 | | R:R:D202 | R:R:T182 | 8.67 | 2 | Yes | Yes | 8 | 8 | 2 | 1 | | R:R:T182 | R:R:Y230 | 4.99 | 2 | Yes | Yes | 8 | 7 | 1 | 1 | | R:R:D312 | R:R:T182 | 7.23 | 2 | Yes | Yes | 8 | 8 | 2 | 1 | | R:R:D202 | R:R:Q205 | 7.83 | 2 | Yes | Yes | 8 | 9 | 2 | 2 | | R:R:D202 | R:R:Y230 | 9.2 | 2 | Yes | Yes | 8 | 7 | 2 | 1 | | R:R:Q205 | R:R:Y230 | 3.38 | 2 | Yes | Yes | 9 | 7 | 2 | 1 | | R:R:D312 | R:R:Q205 | 6.53 | 2 | Yes | Yes | 8 | 9 | 2 | 2 | | R:R:S311 | R:R:Y230 | 7.63 | 0 | No | Yes | 8 | 7 | 2 | 1 | | R:R:S313 | R:R:Y230 | 5.09 | 2 | No | Yes | 6 | 7 | 1 | 1 | | R:R:E287 | R:R:K317 | 5.4 | 2 | Yes | Yes | 3 | 6 | 2 | 2 | | R:R:S313 | R:R:W314 | 3.71 | 2 | No | Yes | 6 | 7 | 1 | 2 | | R:R:E403 | R:R:K317 | 6.75 | 2 | No | Yes | 5 | 6 | 2 | 2 | | R:R:K317 | R:R:K405 | 7.18 | 2 | Yes | Yes | 6 | 4 | 2 | 1 | | R:R:E403 | R:R:K405 | 8.1 | 2 | No | Yes | 5 | 4 | 2 | 1 | | R:R:F408 | R:R:K405 | 3.72 | 0 | Yes | Yes | 7 | 4 | 2 | 1 | | R:R:G231 | R:R:Y230 | 2.9 | 0 | No | Yes | 8 | 7 | 2 | 1 | | R:R:G75 | R:R:K74 | 1.74 | 0 | No | Yes | 5 | 5 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 9.00 | | Average Number Of Links With An Hub | 7.00 | | Average Interaction Strength | 8.42 | | Average Nodes In Shell | 27.00 | | Average Hubs In Shell | 18.00 | | Average Links In Shell | 42.00 | | Average Links Mediated by Hubs In Shell | 42.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of SEP in 7E9H
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | M:M:?1001 | S:S:K74 | 13.16 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | | M:M:?1001 | S:S:R78 | 8.24 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | M:M:?1001 | S:S:S159 | 5.09 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | | M:M:?1001 | S:S:A180 | 5.35 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | | M:M:?1001 | S:S:Y230 | 24.86 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | M:M:?1001 | S:S:S313 | 8.91 | 1 | Yes | No | 0 | 6 | 0 | 1 | | M:M:?1001 | S:S:K317 | 4.78 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | | M:M:?1001 | S:S:K405 | 4.78 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | S:S:K71 | S:S:K74 | 7.18 | 0 | No | Yes | 5 | 5 | 2 | 1 | | S:S:K74 | S:S:R78 | 14.85 | 1 | Yes | Yes | 5 | 4 | 1 | 1 | | S:S:K317 | S:S:K74 | 5.75 | 1 | Yes | Yes | 6 | 5 | 1 | 1 | | S:S:E403 | S:S:K74 | 6.75 | 1 | Yes | Yes | 5 | 5 | 2 | 1 | | S:S:R78 | S:S:S157 | 5.27 | 1 | Yes | Yes | 4 | 5 | 1 | 2 | | S:S:R78 | S:S:Y179 | 12.35 | 1 | Yes | Yes | 4 | 8 | 1 | 2 | | S:S:A180 | S:S:R78 | 4.15 | 1 | Yes | Yes | 6 | 4 | 1 | 1 | | S:S:E403 | S:S:R78 | 12.79 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | | S:S:K405 | S:S:R78 | 9.9 | 1 | Yes | Yes | 4 | 4 | 1 | 1 | | S:S:S157 | S:S:Y179 | 3.82 | 1 | Yes | Yes | 5 | 8 | 2 | 2 | | S:S:A180 | S:S:S157 | 3.42 | 1 | Yes | Yes | 6 | 5 | 1 | 2 | | S:S:A183 | S:S:S159 | 3.42 | 0 | No | Yes | 7 | 9 | 2 | 1 | | S:S:S159 | S:S:S229 | 4.89 | 1 | Yes | No | 9 | 6 | 1 | 2 | | S:S:S159 | S:S:Y230 | 5.09 | 1 | Yes | Yes | 9 | 7 | 1 | 1 | | S:S:A180 | S:S:K405 | 6.42 | 1 | Yes | Yes | 6 | 4 | 1 | 1 | | S:S:D202 | S:S:Y230 | 4.6 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | | S:S:G231 | S:S:Y230 | 4.35 | 0 | No | Yes | 8 | 7 | 2 | 1 | | S:S:F284 | S:S:Y230 | 4.13 | 0 | Yes | Yes | 8 | 7 | 2 | 1 | | S:S:S313 | S:S:Y230 | 7.63 | 1 | No | Yes | 6 | 7 | 1 | 1 | | S:S:D312 | S:S:P336 | 4.83 | 1 | No | Yes | 8 | 5 | 2 | 2 | | S:S:D312 | S:S:K405 | 8.3 | 1 | No | Yes | 8 | 4 | 2 | 1 | | S:S:K317 | S:S:P320 | 3.35 | 1 | Yes | Yes | 6 | 5 | 1 | 2 | | S:S:E403 | S:S:K317 | 5.4 | 1 | Yes | Yes | 5 | 6 | 2 | 1 | | S:S:K405 | S:S:P336 | 3.35 | 1 | Yes | Yes | 4 | 5 | 1 | 2 | | S:S:F408 | S:S:P336 | 8.67 | 1 | Yes | Yes | 7 | 5 | 2 | 2 | | S:S:E403 | S:S:K405 | 6.75 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | | S:S:F408 | S:S:K405 | 7.44 | 1 | Yes | Yes | 7 | 4 | 2 | 1 | | M:M:?1001 | S:S:G158 | 2.9 | 1 | Yes | No | 0 | 4 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 9.00 | | Average Number Of Links With An Hub | 7.00 | | Average Interaction Strength | 8.67 | | Average Nodes In Shell | 23.00 | | Average Hubs In Shell | 16.00 | | Average Links In Shell | 36.00 | | Average Links Mediated by Hubs In Shell | 36.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7R0C | A | Peptide | Vasopressin and Oxytocin | V2 | Homo Sapiens | AVP | - | Arrestin2 | 4.73 | 2022-09-14 | doi.org/10.1126/sciadv.abo7761 |
|
A 2D representation of the interactions of SEP in 7R0C
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?357 | R:R:C358 | 5.38 | 0 | No | No | 6 | 5 | 0 | 1 | | R:R:?359 | R:R:C358 | 3.9 | 4 | No | No | 4 | 5 | 2 | 1 | | R:R:C358 | V:V:P14 | 5.65 | 0 | No | No | 5 | 6 | 1 | 2 | | R:R:?357 | R:R:E356 | 1.12 | 0 | No | No | 6 | 3 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 3.25 | | Average Nodes In Shell | 5.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 4.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of SEP in 7R0C
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?360 | R:R:A361 | 2.58 | 4 | No | No | 6 | 7 | 2 | 1 | | R:R:?362 | R:R:A361 | 2.67 | 4 | Yes | No | 4 | 7 | 0 | 1 | | R:R:A361 | V:V:K10 | 4.82 | 4 | No | Yes | 7 | 9 | 1 | 1 | | R:R:?362 | R:R:?363 | 23.9 | 4 | Yes | Yes | 4 | 7 | 0 | 1 | | R:R:?362 | V:V:R7 | 22.67 | 4 | Yes | No | 4 | 4 | 0 | 1 | | R:R:?362 | V:V:F9 | 10.33 | 4 | Yes | No | 4 | 6 | 0 | 1 | | R:R:?362 | V:V:K10 | 13.16 | 4 | Yes | Yes | 4 | 9 | 0 | 1 | | R:R:?363 | R:R:?364 | 38.83 | 4 | Yes | Yes | 7 | 5 | 1 | 2 | | R:R:?363 | V:V:R7 | 20.61 | 4 | Yes | No | 7 | 4 | 1 | 1 | | R:R:?363 | V:V:V8 | 7.58 | 4 | Yes | Yes | 7 | 7 | 1 | 2 | | R:R:?363 | V:V:K10 | 16.74 | 4 | Yes | Yes | 7 | 9 | 1 | 1 | | R:R:?363 | V:V:K107 | 14.35 | 4 | Yes | No | 7 | 9 | 1 | 2 | | R:R:?364 | V:V:R7 | 19.58 | 4 | Yes | No | 5 | 4 | 2 | 1 | | R:R:?364 | V:V:V8 | 3.79 | 4 | Yes | Yes | 5 | 7 | 2 | 2 | | R:R:?364 | V:V:K107 | 15.55 | 4 | Yes | No | 5 | 9 | 2 | 2 | | V:V:F9 | V:V:R25 | 4.28 | 0 | No | Yes | 6 | 9 | 1 | 2 | | V:V:K10 | V:V:Y21 | 13.14 | 4 | Yes | Yes | 9 | 8 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 5.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 14.55 | | Average Nodes In Shell | 12.00 | | Average Hubs In Shell | 7.00 | | Average Links In Shell | 17.00 | | Average Links Mediated by Hubs In Shell | 16.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of SEP in 7R0C
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?362 | R:R:A361 | 2.67 | 4 | Yes | No | 4 | 7 | 1 | 2 | | R:R:A361 | V:V:K10 | 4.82 | 4 | No | Yes | 7 | 9 | 2 | 1 | | R:R:?362 | R:R:?363 | 23.9 | 4 | Yes | Yes | 4 | 7 | 1 | 0 | | R:R:?362 | V:V:R7 | 22.67 | 4 | Yes | No | 4 | 4 | 1 | 1 | | R:R:?362 | V:V:F9 | 10.33 | 4 | Yes | No | 4 | 6 | 1 | 2 | | R:R:?362 | V:V:K10 | 13.16 | 4 | Yes | Yes | 4 | 9 | 1 | 1 | | R:R:?363 | R:R:?364 | 38.83 | 4 | Yes | Yes | 7 | 5 | 0 | 1 | | R:R:?363 | V:V:R7 | 20.61 | 4 | Yes | No | 7 | 4 | 0 | 1 | | R:R:?363 | V:V:V8 | 7.58 | 4 | Yes | Yes | 7 | 7 | 0 | 1 | | R:R:?363 | V:V:K10 | 16.74 | 4 | Yes | Yes | 7 | 9 | 0 | 1 | | R:R:?363 | V:V:K107 | 14.35 | 4 | Yes | No | 7 | 9 | 0 | 1 | | R:R:?364 | R:R:L365 | 8.22 | 4 | Yes | No | 5 | 5 | 1 | 2 | | R:R:?364 | V:V:R7 | 19.58 | 4 | Yes | No | 5 | 4 | 1 | 1 | | R:R:?364 | V:V:V8 | 3.79 | 4 | Yes | Yes | 5 | 7 | 1 | 1 | | R:R:?364 | V:V:K107 | 15.55 | 4 | Yes | No | 5 | 9 | 1 | 1 | | V:V:L104 | V:V:V8 | 5.96 | 4 | No | Yes | 9 | 7 | 2 | 1 | | V:V:K10 | V:V:Y21 | 13.14 | 4 | Yes | Yes | 9 | 8 | 1 | 2 | | V:V:L104 | V:V:Y21 | 3.52 | 4 | No | Yes | 9 | 8 | 2 | 2 | | V:V:L108 | V:V:Y21 | 11.72 | 4 | Yes | Yes | 8 | 8 | 2 | 2 | | V:V:K107 | V:V:L108 | 4.23 | 4 | No | Yes | 9 | 8 | 1 | 2 | | V:V:G23 | V:V:V8 | 1.84 | 0 | No | Yes | 8 | 7 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 6.00 | | Average Number Of Links With An Hub | 4.00 | | Average Interaction Strength | 20.33 | | Average Nodes In Shell | 14.00 | | Average Hubs In Shell | 7.00 | | Average Links In Shell | 21.00 | | Average Links Mediated by Hubs In Shell | 21.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of SEP in 7R0C
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?362 | R:R:?363 | 23.9 | 4 | Yes | Yes | 4 | 7 | 2 | 1 | | R:R:?362 | V:V:R7 | 22.67 | 4 | Yes | No | 4 | 4 | 2 | 1 | | R:R:?362 | V:V:K10 | 13.16 | 4 | Yes | Yes | 4 | 9 | 2 | 2 | | R:R:?363 | R:R:?364 | 38.83 | 4 | Yes | Yes | 7 | 5 | 1 | 0 | | R:R:?363 | V:V:R7 | 20.61 | 4 | Yes | No | 7 | 4 | 1 | 1 | | R:R:?363 | V:V:V8 | 7.58 | 4 | Yes | Yes | 7 | 7 | 1 | 1 | | R:R:?363 | V:V:K10 | 16.74 | 4 | Yes | Yes | 7 | 9 | 1 | 2 | | R:R:?363 | V:V:K107 | 14.35 | 4 | Yes | No | 7 | 9 | 1 | 1 | | R:R:?364 | R:R:L365 | 8.22 | 4 | Yes | No | 5 | 5 | 0 | 1 | | R:R:?364 | V:V:R7 | 19.58 | 4 | Yes | No | 5 | 4 | 0 | 1 | | R:R:?364 | V:V:V8 | 3.79 | 4 | Yes | Yes | 5 | 7 | 0 | 1 | | R:R:?364 | V:V:K107 | 15.55 | 4 | Yes | No | 5 | 9 | 0 | 1 | | R:R:L365 | V:V:T6 | 2.95 | 0 | No | No | 5 | 4 | 1 | 2 | | R:R:L365 | V:V:R103 | 7.29 | 0 | No | Yes | 5 | 6 | 1 | 2 | | V:V:L104 | V:V:V8 | 5.96 | 4 | No | Yes | 9 | 7 | 2 | 1 | | V:V:K107 | V:V:L108 | 4.23 | 4 | No | Yes | 9 | 8 | 1 | 2 | | V:V:G23 | V:V:V8 | 1.84 | 0 | No | Yes | 8 | 7 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 5.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 17.19 | | Average Nodes In Shell | 13.00 | | Average Hubs In Shell | 7.00 | | Average Links In Shell | 17.00 | | Average Links Mediated by Hubs In Shell | 16.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7SRS | A | Amine | 5-Hydroxytryptamine | 5-HT2B | Homo Sapiens | LSD | - | Arrestin2 | 3.3 | 2022-09-21 | doi.org/10.1016/j.neuron.2022.08.006 |
|
A 2D representation of the interactions of SEP in 7SRS
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:I453 | R:R:Q454 | 2.74 | 0 | No | No | 5 | 8 | 2 | 1 | | R:R:?455 | R:R:Q454 | 10.16 | 0 | Yes | No | 5 | 8 | 0 | 1 | | R:R:?455 | R:R:?456 | 16.93 | 0 | Yes | Yes | 5 | 5 | 0 | 1 | | R:R:?455 | V:V:K11 | 5.98 | 0 | Yes | No | 5 | 9 | 0 | 1 | | R:R:?455 | V:V:R25 | 7.21 | 0 | Yes | No | 5 | 9 | 0 | 1 | | R:R:?455 | V:V:K294 | 7.18 | 0 | Yes | No | 5 | 9 | 0 | 1 | | R:R:?456 | R:R:?457 | 18.92 | 0 | Yes | No | 5 | 8 | 1 | 2 | | R:R:?456 | V:V:F9 | 3.1 | 0 | Yes | No | 5 | 6 | 1 | 2 | | R:R:?456 | V:V:K10 | 2.39 | 0 | Yes | No | 5 | 9 | 1 | 2 | | V:V:F9 | V:V:R25 | 3.21 | 0 | No | No | 6 | 9 | 2 | 1 | | V:V:K11 | V:V:V164 | 4.55 | 0 | No | No | 9 | 8 | 1 | 2 | | V:V:K11 | V:V:L166 | 5.64 | 0 | No | No | 9 | 8 | 1 | 2 | | V:V:L293 | V:V:R25 | 4.86 | 0 | Yes | No | 8 | 9 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 5.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 9.49 | | Average Nodes In Shell | 13.00 | | Average Hubs In Shell | 3.00 | | Average Links In Shell | 13.00 | | Average Links Mediated by Hubs In Shell | 9.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of SEP in 7SRS
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?455 | R:R:Q454 | 10.16 | 0 | Yes | No | 5 | 8 | 1 | 2 | | R:R:?455 | R:R:?456 | 16.93 | 0 | Yes | Yes | 5 | 5 | 1 | 0 | | R:R:?455 | V:V:K11 | 5.98 | 0 | Yes | No | 5 | 9 | 1 | 2 | | R:R:?455 | V:V:R25 | 7.21 | 0 | Yes | No | 5 | 9 | 1 | 2 | | R:R:?455 | V:V:K294 | 7.18 | 0 | Yes | No | 5 | 9 | 1 | 2 | | R:R:?456 | R:R:?457 | 18.92 | 0 | Yes | No | 5 | 8 | 0 | 1 | | R:R:?456 | V:V:F9 | 3.1 | 0 | Yes | No | 5 | 6 | 0 | 1 | | R:R:?456 | V:V:K10 | 2.39 | 0 | Yes | No | 5 | 9 | 0 | 1 | | R:R:?457 | R:R:I458 | 7.26 | 0 | No | No | 8 | 4 | 1 | 2 | | R:R:?457 | V:V:R7 | 11.33 | 0 | No | No | 8 | 4 | 1 | 2 | | V:V:F9 | V:V:R7 | 2.14 | 0 | No | No | 6 | 4 | 1 | 2 | | V:V:F9 | V:V:R25 | 3.21 | 0 | No | No | 6 | 9 | 1 | 2 | | V:V:K10 | V:V:Y21 | 4.78 | 0 | No | Yes | 9 | 8 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 4.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 10.34 | | Average Nodes In Shell | 12.00 | | Average Hubs In Shell | 3.00 | | Average Links In Shell | 13.00 | | Average Links Mediated by Hubs In Shell | 9.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of SEP in 7SRS
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?455 | R:R:?456 | 16.93 | 0 | Yes | Yes | 5 | 5 | 2 | 1 | | R:R:?456 | R:R:?457 | 18.92 | 0 | Yes | No | 5 | 8 | 1 | 0 | | R:R:?456 | V:V:F9 | 3.1 | 0 | Yes | No | 5 | 6 | 1 | 2 | | R:R:?456 | V:V:K10 | 2.39 | 0 | Yes | No | 5 | 9 | 1 | 2 | | R:R:?457 | R:R:I458 | 7.26 | 0 | No | No | 8 | 4 | 0 | 1 | | R:R:?457 | V:V:R7 | 11.33 | 0 | No | No | 8 | 4 | 0 | 1 | | R:R:I458 | V:V:K107 | 2.91 | 0 | No | No | 4 | 9 | 1 | 2 | | R:R:I459 | V:V:R7 | 2.51 | 0 | No | No | 6 | 4 | 2 | 1 | | V:V:F9 | V:V:R7 | 2.14 | 0 | No | No | 6 | 4 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 12.50 | | Average Nodes In Shell | 9.00 | | Average Hubs In Shell | 2.00 | | Average Links In Shell | 9.00 | | Average Links Mediated by Hubs In Shell | 4.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8JD6 | C | Aminoacid | Metabotropic Glutamate | mGlu4; mGlu4 | Homo Sapiens | Phosphoserine | VU0364770 | Gi3/Beta1/Gamma2 | 3.4 | 2023-06-21 | doi.org/10.1038/s41422-023-00830-2 |
|
A 2D representation of the interactions of SEP in 8JD6
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | L:L:?1 | R:R:K74 | 4.78 | 1 | Yes | Yes | 0 | 5 | 0 | 1 | | L:L:?1 | R:R:R78 | 5.15 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | L:L:?1 | R:R:S159 | 8.91 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | | L:L:?1 | R:R:T182 | 5 | 1 | Yes | Yes | 0 | 8 | 0 | 1 | | L:L:?1 | R:R:Y230 | 31.82 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | | L:L:?1 | R:R:S313 | 3.82 | 1 | Yes | No | 0 | 6 | 0 | 1 | | L:L:?1 | R:R:K405 | 8.37 | 1 | Yes | Yes | 0 | 4 | 0 | 1 | | R:R:K74 | R:R:P56 | 8.36 | 1 | Yes | No | 5 | 5 | 1 | 2 | | R:R:P56 | R:R:S157 | 7.13 | 1 | No | Yes | 5 | 5 | 2 | 2 | | R:R:K71 | R:R:K74 | 15.8 | 1 | No | Yes | 5 | 5 | 2 | 1 | | R:R:K74 | R:R:R78 | 9.9 | 1 | Yes | Yes | 5 | 4 | 1 | 1 | | R:R:K74 | R:R:S157 | 4.59 | 1 | Yes | Yes | 5 | 5 | 1 | 2 | | R:R:E287 | R:R:K74 | 6.75 | 0 | No | Yes | 3 | 5 | 2 | 1 | | R:R:R78 | R:R:S157 | 9.22 | 1 | Yes | Yes | 4 | 5 | 1 | 2 | | R:R:R78 | R:R:Y179 | 9.26 | 1 | Yes | Yes | 4 | 8 | 1 | 2 | | R:R:E403 | R:R:R78 | 6.98 | 1 | Yes | Yes | 5 | 4 | 2 | 1 | | R:R:K405 | R:R:R78 | 9.9 | 1 | Yes | Yes | 4 | 4 | 1 | 1 | | R:R:S157 | R:R:Y179 | 7.63 | 1 | Yes | Yes | 5 | 8 | 2 | 2 | | R:R:S159 | R:R:S181 | 6.52 | 1 | Yes | No | 9 | 8 | 1 | 2 | | R:R:S159 | R:R:Y230 | 6.36 | 1 | Yes | Yes | 9 | 7 | 1 | 1 | | R:R:A180 | R:R:K405 | 6.42 | 0 | No | Yes | 6 | 4 | 2 | 1 | | R:R:D202 | R:R:T182 | 8.67 | 1 | Yes | Yes | 8 | 8 | 2 | 1 | | R:R:T182 | R:R:Y230 | 3.75 | 1 | Yes | Yes | 8 | 7 | 1 | 1 | | R:R:D312 | R:R:T182 | 5.78 | 1 | Yes | Yes | 8 | 8 | 2 | 1 | | R:R:D202 | R:R:Y230 | 6.9 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | | R:R:D202 | R:R:F284 | 3.58 | 1 | Yes | Yes | 8 | 8 | 2 | 2 | | R:R:G231 | R:R:Y230 | 4.35 | 0 | No | Yes | 8 | 7 | 2 | 1 | | R:R:F284 | R:R:Y230 | 4.13 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | | R:R:S311 | R:R:Y230 | 5.09 | 1 | No | Yes | 8 | 7 | 2 | 1 | | R:R:S313 | R:R:Y230 | 3.82 | 1 | No | Yes | 6 | 7 | 1 | 1 | | R:R:F284 | R:R:S311 | 13.21 | 1 | Yes | No | 8 | 8 | 2 | 2 | | R:R:S313 | R:R:W314 | 6.18 | 1 | No | Yes | 6 | 7 | 1 | 2 | | R:R:F408 | R:R:K405 | 6.2 | 1 | Yes | Yes | 7 | 4 | 2 | 1 | | R:R:A183 | R:R:S159 | 3.42 | 0 | No | Yes | 7 | 9 | 2 | 1 | | L:L:?1 | R:R:G158 | 2.9 | 1 | Yes | No | 0 | 4 | 0 | 1 | | R:R:G75 | R:R:K74 | 1.74 | 0 | No | Yes | 5 | 5 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 8.00 | | Average Number Of Links With An Hub | 6.00 | | Average Interaction Strength | 8.84 | | Average Nodes In Shell | 26.00 | | Average Hubs In Shell | 15.00 | | Average Links In Shell | 36.00 | | Average Links Mediated by Hubs In Shell | 36.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of SEP in 8JD6
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | M:M:?1 | S:S:K74 | 10.76 | 3 | Yes | Yes | 0 | 5 | 0 | 1 | | M:M:?1 | S:S:R78 | 10.3 | 3 | Yes | Yes | 0 | 4 | 0 | 1 | | M:M:?1 | S:S:S159 | 3.82 | 3 | Yes | No | 0 | 9 | 0 | 1 | | M:M:?1 | S:S:A180 | 5.35 | 3 | Yes | No | 0 | 6 | 0 | 1 | | M:M:?1 | S:S:Y230 | 26.84 | 3 | Yes | Yes | 0 | 7 | 0 | 1 | | M:M:?1 | S:S:S313 | 10.19 | 3 | Yes | No | 0 | 6 | 0 | 1 | | M:M:?1 | S:S:K317 | 3.59 | 3 | Yes | No | 0 | 6 | 0 | 1 | | M:M:?1 | S:S:K405 | 7.18 | 3 | Yes | Yes | 0 | 4 | 0 | 1 | | S:S:K71 | S:S:K74 | 10.06 | 0 | No | Yes | 5 | 5 | 2 | 1 | | S:S:K74 | S:S:R78 | 14.85 | 3 | Yes | Yes | 5 | 4 | 1 | 1 | | S:S:E287 | S:S:K74 | 13.5 | 0 | Yes | Yes | 3 | 5 | 2 | 1 | | S:S:E403 | S:S:K74 | 8.1 | 3 | Yes | Yes | 5 | 5 | 2 | 1 | | S:S:R78 | S:S:S157 | 3.95 | 3 | Yes | Yes | 4 | 5 | 1 | 2 | | S:S:R78 | S:S:Y179 | 9.26 | 3 | Yes | Yes | 4 | 8 | 1 | 2 | | S:S:A180 | S:S:R78 | 4.15 | 3 | No | Yes | 6 | 4 | 1 | 1 | | S:S:E403 | S:S:R78 | 13.96 | 3 | Yes | Yes | 5 | 4 | 2 | 1 | | S:S:K405 | S:S:R78 | 9.9 | 3 | Yes | Yes | 4 | 4 | 1 | 1 | | S:S:R78 | S:S:V409 | 3.92 | 3 | Yes | No | 4 | 7 | 1 | 2 | | S:S:S157 | S:S:Y179 | 3.82 | 3 | Yes | Yes | 5 | 8 | 2 | 2 | | S:S:S159 | S:S:S181 | 4.89 | 3 | No | No | 9 | 8 | 1 | 2 | | S:S:S159 | S:S:Y230 | 5.09 | 3 | No | Yes | 9 | 7 | 1 | 1 | | S:S:V409 | S:S:Y179 | 8.83 | 3 | No | Yes | 7 | 8 | 2 | 2 | | S:S:A180 | S:S:K405 | 6.42 | 3 | No | Yes | 6 | 4 | 1 | 1 | | S:S:D202 | S:S:Y230 | 6.9 | 3 | Yes | Yes | 8 | 7 | 2 | 1 | | S:S:G231 | S:S:Y230 | 4.35 | 0 | No | Yes | 8 | 7 | 2 | 1 | | S:S:S311 | S:S:Y230 | 3.82 | 0 | No | Yes | 8 | 7 | 2 | 1 | | S:S:S313 | S:S:Y230 | 3.82 | 3 | No | Yes | 6 | 7 | 1 | 1 | | S:S:E287 | S:S:S313 | 4.31 | 0 | Yes | No | 3 | 6 | 2 | 1 | | S:S:E287 | S:S:K317 | 5.4 | 0 | Yes | No | 3 | 6 | 2 | 1 | | S:S:D312 | S:S:K405 | 11.06 | 3 | Yes | Yes | 8 | 4 | 2 | 1 | | S:S:E403 | S:S:K317 | 5.4 | 3 | Yes | No | 5 | 6 | 2 | 1 | | S:S:E403 | S:S:K405 | 8.1 | 3 | Yes | Yes | 5 | 4 | 2 | 1 | | S:S:F408 | S:S:K405 | 4.96 | 0 | Yes | Yes | 7 | 4 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 8.00 | | Average Number Of Links With An Hub | 4.00 | | Average Interaction Strength | 9.75 | | Average Nodes In Shell | 21.00 | | Average Hubs In Shell | 12.00 | | Average Links In Shell | 33.00 | | Average Links Mediated by Hubs In Shell | 32.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8WRZ | A | Lipid | Cannabinoid | CB1 | Homo Sapiens | PubChem 102336704 | - | Arrestin2 | 3.6 | 2024-02-28 | doi.org/10.1093/procel/pwad055 |
|
A 2D representation of the interactions of SEP in 8WRZ
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?417 | V:V:R7 | 29.88 | 3 | Yes | No | 4 | 4 | 0 | 1 | | R:R:?418 | V:V:R7 | 17.52 | 3 | Yes | No | 7 | 4 | 1 | 1 | | R:R:?419 | V:V:R7 | 6.18 | 3 | Yes | No | 5 | 4 | 2 | 1 | | V:V:K10 | V:V:T19 | 3 | 3 | Yes | Yes | 9 | 7 | 1 | 2 | | V:V:K10 | V:V:Y21 | 13.14 | 3 | Yes | Yes | 9 | 8 | 1 | 2 | | R:R:?417 | V:V:K10 | 5.98 | 3 | Yes | Yes | 4 | 9 | 0 | 1 | | R:R:?418 | V:V:K10 | 7.18 | 3 | Yes | Yes | 7 | 9 | 1 | 1 | | V:V:T19 | V:V:Y21 | 9.99 | 3 | Yes | Yes | 7 | 8 | 2 | 2 | | R:R:?418 | V:V:K107 | 4.78 | 3 | Yes | No | 7 | 9 | 1 | 2 | | R:R:?419 | V:V:K107 | 10.76 | 3 | Yes | No | 5 | 9 | 2 | 2 | | R:R:?415 | R:R:A416 | 2.58 | 6 | Yes | No | 6 | 7 | 2 | 1 | | R:R:?417 | R:R:A416 | 2.67 | 3 | Yes | No | 4 | 7 | 0 | 1 | | R:R:?417 | R:R:?418 | 18.92 | 3 | Yes | Yes | 4 | 7 | 0 | 1 | | R:R:?418 | R:R:?419 | 32.86 | 3 | Yes | Yes | 7 | 5 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 4.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 14.36 | | Average Nodes In Shell | 10.00 | | Average Hubs In Shell | 7.00 | | Average Links In Shell | 14.00 | | Average Links Mediated by Hubs In Shell | 14.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of SEP in 8WRZ
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?417 | V:V:R7 | 29.88 | 3 | Yes | No | 4 | 4 | 1 | 1 | | R:R:?418 | V:V:R7 | 17.52 | 3 | Yes | No | 7 | 4 | 0 | 1 | | R:R:?419 | V:V:R7 | 6.18 | 3 | Yes | No | 5 | 4 | 1 | 1 | | V:V:K10 | V:V:T19 | 3 | 3 | Yes | Yes | 9 | 7 | 1 | 2 | | V:V:K10 | V:V:Y21 | 13.14 | 3 | Yes | Yes | 9 | 8 | 1 | 2 | | R:R:?417 | V:V:K10 | 5.98 | 3 | Yes | Yes | 4 | 9 | 1 | 1 | | R:R:?418 | V:V:K10 | 7.18 | 3 | Yes | Yes | 7 | 9 | 0 | 1 | | V:V:T19 | V:V:Y21 | 9.99 | 3 | Yes | Yes | 7 | 8 | 2 | 2 | | V:V:L108 | V:V:Y21 | 7.03 | 3 | Yes | Yes | 8 | 8 | 2 | 2 | | V:V:K107 | V:V:L108 | 5.64 | 3 | No | Yes | 9 | 8 | 1 | 2 | | R:R:?418 | V:V:K107 | 4.78 | 3 | Yes | No | 7 | 9 | 0 | 1 | | R:R:?419 | V:V:K107 | 10.76 | 3 | Yes | No | 5 | 9 | 1 | 1 | | R:R:?417 | R:R:A416 | 2.67 | 3 | Yes | No | 4 | 7 | 1 | 2 | | R:R:?417 | R:R:?418 | 18.92 | 3 | Yes | Yes | 4 | 7 | 1 | 0 | | R:R:?418 | R:R:?419 | 32.86 | 3 | Yes | Yes | 7 | 5 | 0 | 1 | | R:R:?419 | R:R:L420 | 4.7 | 3 | Yes | No | 5 | 5 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 5.00 | | Average Number Of Links With An Hub | 3.00 | | Average Interaction Strength | 16.25 | | Average Nodes In Shell | 11.00 | | Average Hubs In Shell | 7.00 | | Average Links In Shell | 16.00 | | Average Links Mediated by Hubs In Shell | 16.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of SEP in 8WRZ
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:L420 | V:V:T6 | 2.95 | 0 | No | No | 5 | 4 | 1 | 2 | | R:R:?417 | V:V:R7 | 29.88 | 3 | Yes | No | 4 | 4 | 2 | 1 | | R:R:?418 | V:V:R7 | 17.52 | 3 | Yes | No | 7 | 4 | 1 | 1 | | R:R:?419 | V:V:R7 | 6.18 | 3 | Yes | No | 5 | 4 | 0 | 1 | | R:R:?417 | V:V:K10 | 5.98 | 3 | Yes | Yes | 4 | 9 | 2 | 2 | | R:R:?418 | V:V:K10 | 7.18 | 3 | Yes | Yes | 7 | 9 | 1 | 2 | | R:R:L420 | V:V:R103 | 3.64 | 0 | No | No | 5 | 6 | 1 | 2 | | V:V:K107 | V:V:L108 | 5.64 | 3 | No | Yes | 9 | 8 | 1 | 2 | | R:R:?418 | V:V:K107 | 4.78 | 3 | Yes | No | 7 | 9 | 1 | 1 | | R:R:?419 | V:V:K107 | 10.76 | 3 | Yes | No | 5 | 9 | 0 | 1 | | R:R:?417 | R:R:?418 | 18.92 | 3 | Yes | Yes | 4 | 7 | 2 | 1 | | R:R:?418 | R:R:?419 | 32.86 | 3 | Yes | Yes | 7 | 5 | 1 | 0 | | R:R:?419 | R:R:L420 | 4.7 | 3 | Yes | No | 5 | 5 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 4.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 13.62 | | Average Nodes In Shell | 10.00 | | Average Hubs In Shell | 5.00 | | Average Links In Shell | 13.00 | | Average Links Mediated by Hubs In Shell | 11.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8WU1 | A | Lipid | Cannabinoid | CB1 | Homo Sapiens | PubChem 119025665 | - | Arrestin2 | 3.2 | 2024-03-20 | doi.org/10.1016/j.cell.2023.11.017 |
|
A 2D representation of the interactions of SEP in 8WU1
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?431 | R:R:C430 | 7.82 | 0 | No | No | 4 | 5 | 2 | 1 | | R:R:?429 | R:R:C430 | 2.7 | 0 | No | No | 6 | 5 | 0 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 1.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 2.70 | | Average Nodes In Shell | 3.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 2.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of SEP in 8WU1
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?434 | R:R:A433 | 4.02 | 6 | No | No | 4 | 7 | 0 | 1 | | R:R:?434 | R:R:?435 | 19.02 | 6 | No | Yes | 4 | 7 | 0 | 1 | | R:R:?434 | V:V:R7 | 20.66 | 6 | No | No | 4 | 5 | 0 | 1 | | R:R:?435 | R:R:?436 | 21.02 | 6 | Yes | No | 7 | 5 | 1 | 2 | | R:R:?435 | V:V:R7 | 13.43 | 6 | Yes | No | 7 | 5 | 1 | 1 | | R:R:?435 | V:V:V8 | 3.8 | 6 | Yes | No | 7 | 7 | 1 | 2 | | R:R:?435 | V:V:K10 | 8.39 | 6 | Yes | No | 7 | 9 | 1 | 2 | | R:R:?435 | V:V:K107 | 9.59 | 6 | Yes | Yes | 7 | 9 | 1 | 2 | | R:R:?436 | V:V:R7 | 14.46 | 6 | No | No | 5 | 5 | 2 | 1 | | R:R:?436 | V:V:K107 | 3.6 | 6 | No | Yes | 5 | 9 | 2 | 2 | | R:R:?432 | R:R:A433 | 2.59 | 0 | Yes | No | 6 | 7 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 14.57 | | Average Nodes In Shell | 9.00 | | Average Hubs In Shell | 3.00 | | Average Links In Shell | 11.00 | | Average Links Mediated by Hubs In Shell | 8.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of SEP in 8WU1
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?434 | R:R:A433 | 4.02 | 6 | No | No | 4 | 7 | 1 | 2 | | R:R:?434 | R:R:?435 | 19.02 | 6 | No | Yes | 4 | 7 | 1 | 0 | | R:R:?434 | V:V:R7 | 20.66 | 6 | No | No | 4 | 5 | 1 | 1 | | R:R:?435 | R:R:?436 | 21.02 | 6 | Yes | No | 7 | 5 | 0 | 1 | | R:R:?435 | V:V:R7 | 13.43 | 6 | Yes | No | 7 | 5 | 0 | 1 | | R:R:?435 | V:V:V8 | 3.8 | 6 | Yes | No | 7 | 7 | 0 | 1 | | R:R:?435 | V:V:K10 | 8.39 | 6 | Yes | No | 7 | 9 | 0 | 1 | | R:R:?435 | V:V:K107 | 9.59 | 6 | Yes | Yes | 7 | 9 | 0 | 1 | | R:R:?436 | V:V:R7 | 14.46 | 6 | No | No | 5 | 5 | 1 | 1 | | R:R:?436 | V:V:K107 | 3.6 | 6 | No | Yes | 5 | 9 | 1 | 1 | | R:R:L437 | V:V:V8 | 2.98 | 6 | Yes | No | 5 | 7 | 2 | 1 | | R:R:L437 | V:V:L104 | 4.15 | 6 | Yes | Yes | 5 | 9 | 2 | 2 | | R:R:L437 | V:V:K107 | 4.23 | 6 | Yes | Yes | 5 | 9 | 2 | 1 | | V:V:L104 | V:V:V8 | 4.47 | 6 | Yes | No | 9 | 7 | 2 | 1 | | V:V:K10 | V:V:Y21 | 11.94 | 0 | No | Yes | 9 | 8 | 1 | 2 | | V:V:L104 | V:V:Y21 | 3.52 | 6 | Yes | Yes | 9 | 8 | 2 | 2 | | V:V:L108 | V:V:Y21 | 9.38 | 0 | Yes | Yes | 7 | 8 | 2 | 2 | | V:V:K107 | V:V:L108 | 4.23 | 6 | Yes | Yes | 9 | 7 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 6.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 12.54 | | Average Nodes In Shell | 12.00 | | Average Hubs In Shell | 6.00 | | Average Links In Shell | 18.00 | | Average Links Mediated by Hubs In Shell | 15.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of SEP in 8WU1
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?434 | R:R:?435 | 19.02 | 6 | No | Yes | 4 | 7 | 2 | 1 | | R:R:?434 | V:V:R7 | 20.66 | 6 | No | No | 4 | 5 | 2 | 1 | | R:R:?435 | R:R:?436 | 21.02 | 6 | Yes | No | 7 | 5 | 1 | 0 | | R:R:?435 | V:V:R7 | 13.43 | 6 | Yes | No | 7 | 5 | 1 | 1 | | R:R:?435 | V:V:V8 | 3.8 | 6 | Yes | No | 7 | 7 | 1 | 2 | | R:R:?435 | V:V:K10 | 8.39 | 6 | Yes | No | 7 | 9 | 1 | 2 | | R:R:?435 | V:V:K107 | 9.59 | 6 | Yes | Yes | 7 | 9 | 1 | 1 | | R:R:?436 | V:V:R7 | 14.46 | 6 | No | No | 5 | 5 | 0 | 1 | | R:R:?436 | V:V:K107 | 3.6 | 6 | No | Yes | 5 | 9 | 0 | 1 | | R:R:L437 | V:V:V8 | 2.98 | 6 | Yes | No | 5 | 7 | 2 | 2 | | R:R:L437 | V:V:K107 | 4.23 | 6 | Yes | Yes | 5 | 9 | 2 | 1 | | V:V:K107 | V:V:L108 | 4.23 | 6 | Yes | Yes | 9 | 7 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 13.03 | | Average Nodes In Shell | 9.00 | | Average Hubs In Shell | 4.00 | | Average Links In Shell | 12.00 | | Average Links Mediated by Hubs In Shell | 10.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8ZYT | A | Peptide | Neurotensin | NTS1 | Homo Sapiens | Neurotensin peptide 8-13 | SBI-553 | Arrestin2 | 2.65 | 2025-04-09 | doi.org/10.1038/s41422-025-01095-7 |
|
A 2D representation of the interactions of SEP in 8ZYT
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?407 | R:R:L408 | 6.82 | 1 | Yes | No | 7 | 3 | 2 | 1 | | R:R:?409 | R:R:L408 | 4.71 | 1 | No | No | 6 | 3 | 0 | 1 | | R:R:L408 | V:V:K10 | 5.64 | 0 | No | Yes | 3 | 9 | 1 | 2 | | R:R:?409 | R:R:?410 | 18.02 | 1 | No | Yes | 6 | 6 | 0 | 1 | | R:R:?409 | V:V:R7 | 17.56 | 1 | No | Yes | 6 | 4 | 0 | 1 | | R:R:?410 | R:R:N411 | 9.34 | 1 | Yes | No | 6 | 6 | 1 | 2 | | R:R:?410 | V:V:R7 | 17.56 | 1 | Yes | Yes | 6 | 4 | 1 | 1 | | R:R:?410 | V:V:V8 | 8.87 | 1 | Yes | No | 6 | 7 | 1 | 2 | | R:R:?410 | V:V:K10 | 11.99 | 1 | Yes | Yes | 6 | 9 | 1 | 2 | | R:R:?410 | V:V:Y21 | 1.99 | 1 | Yes | Yes | 6 | 8 | 1 | 2 | | R:R:?410 | V:V:K107 | 6 | 1 | Yes | No | 6 | 9 | 1 | 2 | | R:R:N411 | V:V:R7 | 12.05 | 1 | No | Yes | 6 | 4 | 2 | 1 | | V:V:K10 | V:V:Y21 | 9.55 | 1 | Yes | Yes | 9 | 8 | 2 | 2 | | V:V:K107 | V:V:Y21 | 2.39 | 1 | No | Yes | 9 | 8 | 2 | 2 | | V:V:R7 | V:V:T6 | 1.29 | 1 | Yes | No | 4 | 4 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 13.43 | | Average Nodes In Shell | 11.00 | | Average Hubs In Shell | 5.00 | | Average Links In Shell | 15.00 | | Average Links Mediated by Hubs In Shell | 14.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of SEP in 8ZYT
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?409 | R:R:L408 | 4.71 | 1 | No | No | 6 | 3 | 1 | 2 | | R:R:L408 | V:V:K10 | 5.64 | 0 | No | Yes | 3 | 9 | 2 | 1 | | R:R:?409 | R:R:?410 | 18.02 | 1 | No | Yes | 6 | 6 | 1 | 0 | | R:R:?409 | V:V:R7 | 17.56 | 1 | No | Yes | 6 | 4 | 1 | 1 | | R:R:?410 | R:R:N411 | 9.34 | 1 | Yes | No | 6 | 6 | 0 | 1 | | R:R:?410 | V:V:R7 | 17.56 | 1 | Yes | Yes | 6 | 4 | 0 | 1 | | R:R:?410 | V:V:V8 | 8.87 | 1 | Yes | No | 6 | 7 | 0 | 1 | | R:R:?410 | V:V:K10 | 11.99 | 1 | Yes | Yes | 6 | 9 | 0 | 1 | | R:R:?410 | V:V:Y21 | 1.99 | 1 | Yes | Yes | 6 | 8 | 0 | 1 | | R:R:?410 | V:V:K107 | 6 | 1 | Yes | No | 6 | 9 | 0 | 1 | | R:R:N411 | V:V:R7 | 12.05 | 1 | No | Yes | 6 | 4 | 1 | 1 | | V:V:L104 | V:V:V8 | 4.47 | 1 | Yes | No | 9 | 7 | 2 | 1 | | V:V:K10 | V:V:T19 | 3 | 1 | Yes | No | 9 | 7 | 1 | 2 | | V:V:K10 | V:V:Y21 | 9.55 | 1 | Yes | Yes | 9 | 8 | 1 | 1 | | V:V:T19 | V:V:Y21 | 6.24 | 1 | No | Yes | 7 | 8 | 2 | 1 | | V:V:V40 | V:V:Y21 | 3.79 | 1 | Yes | Yes | 8 | 8 | 2 | 1 | | V:V:L42 | V:V:Y21 | 2.34 | 1 | No | Yes | 5 | 8 | 2 | 1 | | V:V:L104 | V:V:Y21 | 4.69 | 1 | Yes | Yes | 9 | 8 | 2 | 1 | | V:V:K107 | V:V:Y21 | 2.39 | 1 | No | Yes | 9 | 8 | 1 | 1 | | V:V:L108 | V:V:Y21 | 15.24 | 1 | Yes | Yes | 8 | 8 | 2 | 1 | | V:V:L104 | V:V:V40 | 5.96 | 1 | Yes | Yes | 9 | 8 | 2 | 2 | | V:V:L108 | V:V:L42 | 6.92 | 1 | Yes | No | 8 | 5 | 2 | 2 | | V:V:L104 | V:V:L108 | 2.77 | 1 | Yes | Yes | 9 | 8 | 2 | 2 | | V:V:K107 | V:V:L108 | 5.64 | 1 | No | Yes | 9 | 8 | 1 | 2 | | V:V:R7 | V:V:T6 | 1.29 | 1 | Yes | No | 4 | 4 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 7.00 | | Average Number Of Links With An Hub | 3.00 | | Average Interaction Strength | 10.54 | | Average Nodes In Shell | 15.00 | | Average Hubs In Shell | 7.00 | | Average Links In Shell | 25.00 | | Average Links Mediated by Hubs In Shell | 24.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8ZYU | A | Peptide | Neurotensin | NTS1 | Homo Sapiens | Neurotensin peptide 8-13 | SBI-553 | Arrestin2 | 2.65 | 2025-04-16 | doi.org/10.1038/s41422-025-01095-7 |
|
A 2D representation of the interactions of SEP in 8ZYU
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?404 | R:R:N405 | 5.84 | 0 | No | No | 7 | 7 | 0 | 1 | | R:R:?404 | V:V:K11 | 7.19 | 0 | No | No | 7 | 9 | 0 | 1 | | R:R:?404 | V:V:R165 | 4.13 | 0 | No | Yes | 7 | 5 | 0 | 1 | | R:R:?407 | V:V:K11 | 19.68 | 9 | Yes | No | 7 | 9 | 2 | 1 | | V:V:K11 | V:V:V164 | 4.55 | 0 | No | No | 9 | 8 | 1 | 2 | | V:V:E145 | V:V:R165 | 11.63 | 0 | No | Yes | 7 | 5 | 2 | 1 | | V:V:K147 | V:V:S163 | 6.12 | 4 | Yes | No | 7 | 8 | 2 | 2 | | V:V:K147 | V:V:R165 | 13.61 | 4 | Yes | Yes | 7 | 5 | 2 | 1 | | V:V:R165 | V:V:S163 | 5.27 | 4 | Yes | No | 5 | 8 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 5.72 | | Average Nodes In Shell | 9.00 | | Average Hubs In Shell | 3.00 | | Average Links In Shell | 9.00 | | Average Links Mediated by Hubs In Shell | 6.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of SEP in 8ZYU
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?407 | R:R:L408 | 6.82 | 9 | Yes | No | 7 | 3 | 2 | 1 | | R:R:?409 | R:R:L408 | 3.53 | 19 | No | No | 6 | 3 | 0 | 1 | | R:R:L408 | V:V:K10 | 7.05 | 0 | No | No | 3 | 9 | 1 | 2 | | R:R:?409 | R:R:?410 | 19.02 | 19 | No | Yes | 6 | 6 | 0 | 1 | | R:R:?409 | V:V:R7 | 14.46 | 19 | No | No | 6 | 4 | 0 | 1 | | R:R:?410 | R:R:N411 | 4.67 | 19 | Yes | No | 6 | 6 | 1 | 2 | | R:R:?410 | V:V:R7 | 17.56 | 19 | Yes | No | 6 | 4 | 1 | 1 | | R:R:?410 | V:V:V8 | 8.87 | 19 | Yes | No | 6 | 7 | 1 | 2 | | R:R:?410 | V:V:K10 | 10.79 | 19 | Yes | No | 6 | 9 | 1 | 2 | | R:R:?410 | V:V:K107 | 4.8 | 19 | Yes | No | 6 | 9 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 12.34 | | Average Nodes In Shell | 9.00 | | Average Hubs In Shell | 2.00 | | Average Links In Shell | 10.00 | | Average Links Mediated by Hubs In Shell | 7.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of SEP in 8ZYU
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?409 | R:R:L408 | 3.53 | 19 | No | No | 6 | 3 | 1 | 2 | | R:R:L408 | V:V:K10 | 7.05 | 0 | No | No | 3 | 9 | 2 | 1 | | R:R:?409 | R:R:?410 | 19.02 | 19 | No | Yes | 6 | 6 | 1 | 0 | | R:R:?409 | V:V:R7 | 14.46 | 19 | No | No | 6 | 4 | 1 | 1 | | R:R:?410 | R:R:N411 | 4.67 | 19 | Yes | No | 6 | 6 | 0 | 1 | | R:R:?410 | V:V:R7 | 17.56 | 19 | Yes | No | 6 | 4 | 0 | 1 | | R:R:?410 | V:V:V8 | 8.87 | 19 | Yes | No | 6 | 7 | 0 | 1 | | R:R:?410 | V:V:K10 | 10.79 | 19 | Yes | No | 6 | 9 | 0 | 1 | | R:R:?410 | V:V:K107 | 4.8 | 19 | Yes | No | 6 | 9 | 0 | 1 | | V:V:L104 | V:V:V8 | 5.96 | 0 | Yes | No | 9 | 7 | 2 | 1 | | V:V:K10 | V:V:Y21 | 11.94 | 0 | No | Yes | 9 | 8 | 1 | 2 | | V:V:L104 | V:V:Y21 | 5.86 | 0 | Yes | Yes | 9 | 8 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 6.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 10.95 | | Average Nodes In Shell | 10.00 | | Average Hubs In Shell | 3.00 | | Average Links In Shell | 12.00 | | Average Links Mediated by Hubs In Shell | 9.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8ZYY | A | Peptide | Neurotensin | NTS1 | Homo Sapiens | Neurotensin peptide 8-13 | SBI-553 | Arrestin2 | 2.83 | 2025-04-09 | doi.org/10.1038/s41422-025-01095-7 |
|
A 2D representation of the interactions of SEP in 8ZYY
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?404 | R:R:N405 | 4.67 | 0 | No | No | 7 | 7 | 0 | 1 | | R:R:?407 | R:R:H406 | 4.22 | 2 | Yes | No | 7 | 8 | 2 | 1 | | R:R:?404 | R:R:H406 | 2.19 | 0 | No | No | 7 | 8 | 0 | 1 | | R:R:H406 | V:V:K294 | 1.31 | 0 | No | No | 8 | 9 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 3.43 | | Average Nodes In Shell | 5.00 | | Average Hubs In Shell | 1.00 | | Average Links In Shell | 4.00 | | Average Links Mediated by Hubs In Shell | 1.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of SEP in 8ZYY
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?407 | R:R:L408 | 4.55 | 2 | Yes | No | 7 | 3 | 2 | 1 | | R:R:?409 | R:R:L408 | 4.71 | 2 | Yes | No | 6 | 3 | 0 | 1 | | R:R:L408 | V:V:K10 | 4.23 | 2 | No | Yes | 3 | 9 | 1 | 1 | | R:R:?409 | R:R:?410 | 18.02 | 2 | Yes | Yes | 6 | 6 | 0 | 1 | | R:R:?409 | V:V:R7 | 18.6 | 2 | Yes | No | 6 | 4 | 0 | 1 | | R:R:?409 | V:V:K10 | 3.6 | 2 | Yes | Yes | 6 | 9 | 0 | 1 | | R:R:?410 | R:R:N411 | 11.68 | 2 | Yes | No | 6 | 6 | 1 | 2 | | R:R:?410 | V:V:R7 | 18.6 | 2 | Yes | No | 6 | 4 | 1 | 1 | | R:R:?410 | V:V:V8 | 8.87 | 2 | Yes | No | 6 | 7 | 1 | 2 | | R:R:?410 | V:V:K10 | 10.79 | 2 | Yes | Yes | 6 | 9 | 1 | 1 | | R:R:?410 | V:V:K107 | 4.8 | 2 | Yes | No | 6 | 9 | 1 | 2 | | R:R:N411 | V:V:R7 | 7.23 | 2 | No | No | 6 | 4 | 2 | 1 | | V:V:K10 | V:V:Y21 | 13.14 | 2 | Yes | Yes | 9 | 8 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 4.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 11.23 | | Average Nodes In Shell | 10.00 | | Average Hubs In Shell | 5.00 | | Average Links In Shell | 13.00 | | Average Links Mediated by Hubs In Shell | 12.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of SEP in 8ZYY
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?409 | R:R:L408 | 4.71 | 2 | Yes | No | 6 | 3 | 1 | 2 | | R:R:L408 | V:V:K10 | 4.23 | 2 | No | Yes | 3 | 9 | 2 | 1 | | R:R:?409 | R:R:?410 | 18.02 | 2 | Yes | Yes | 6 | 6 | 1 | 0 | | R:R:?409 | V:V:R7 | 18.6 | 2 | Yes | No | 6 | 4 | 1 | 1 | | R:R:?409 | V:V:K10 | 3.6 | 2 | Yes | Yes | 6 | 9 | 1 | 1 | | R:R:?410 | R:R:N411 | 11.68 | 2 | Yes | No | 6 | 6 | 0 | 1 | | R:R:?410 | V:V:R7 | 18.6 | 2 | Yes | No | 6 | 4 | 0 | 1 | | R:R:?410 | V:V:V8 | 8.87 | 2 | Yes | No | 6 | 7 | 0 | 1 | | R:R:?410 | V:V:K10 | 10.79 | 2 | Yes | Yes | 6 | 9 | 0 | 1 | | R:R:?410 | V:V:K107 | 4.8 | 2 | Yes | No | 6 | 9 | 0 | 1 | | R:R:N411 | V:V:R7 | 7.23 | 2 | No | No | 6 | 4 | 1 | 1 | | V:V:K10 | V:V:Y21 | 13.14 | 2 | Yes | Yes | 9 | 8 | 1 | 2 | | R:R:N411 | V:V:T6 | 2.92 | 2 | No | No | 6 | 4 | 1 | 2 | | V:V:G23 | V:V:V8 | 1.84 | 0 | No | No | 8 | 7 | 2 | 1 | | R:R:A412 | V:V:V8 | 1.7 | 0 | No | No | 6 | 7 | 2 | 1 | |
| Statistics | Value |
|---|
| Average Number Of Links | 6.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 12.13 | | Average Nodes In Shell | 12.00 | | Average Hubs In Shell | 4.00 | | Average Links In Shell | 15.00 | | Average Links Mediated by Hubs In Shell | 11.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 9II2 | C | Aminoacid | Metabotropic Glutamate | mGlu3; mGlu3 | Homo Sapiens | Glutamate | - | Arrestin2 | 3.7 | 2025-03-05 | doi.org/10.1038/s41589-025-01858-8 |
|
A 2D representation of the interactions of SEP in 9II2
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?856 | R:R:Q855 | 23.77 | 2 | No | No | 5 | 4 | 0 | 1 | | R:R:Q855 | V:V:A12 | 6.06 | 0 | No | No | 4 | 5 | 1 | 2 | | R:R:?856 | R:R:?857 | 19.02 | 2 | No | Yes | 5 | 5 | 0 | 1 | | R:R:?856 | V:V:K11 | 3.6 | 2 | No | Yes | 5 | 9 | 0 | 1 | | R:R:?857 | R:R:A858 | 2.68 | 2 | Yes | No | 5 | 5 | 1 | 2 | | R:R:?857 | V:V:K11 | 14.39 | 2 | Yes | Yes | 5 | 9 | 1 | 1 | | R:R:?857 | V:V:R25 | 11.36 | 2 | Yes | Yes | 5 | 9 | 1 | 2 | | R:R:?857 | V:V:K294 | 4.8 | 2 | Yes | No | 5 | 9 | 1 | 2 | | V:V:K11 | V:V:V164 | 3.04 | 2 | Yes | Yes | 9 | 8 | 1 | 2 | | V:V:K11 | V:V:L166 | 4.23 | 2 | Yes | No | 9 | 8 | 1 | 2 | | V:V:L166 | V:V:R25 | 9.72 | 0 | No | Yes | 8 | 9 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 15.46 | | Average Nodes In Shell | 10.00 | | Average Hubs In Shell | 4.00 | | Average Links In Shell | 11.00 | | Average Links Mediated by Hubs In Shell | 9.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of SEP in 9II2
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?856 | R:R:Q855 | 23.77 | 2 | No | No | 5 | 4 | 1 | 2 | | R:R:?856 | R:R:?857 | 19.02 | 2 | No | Yes | 5 | 5 | 1 | 0 | | R:R:?856 | V:V:K11 | 3.6 | 2 | No | Yes | 5 | 9 | 1 | 1 | | R:R:?857 | R:R:A858 | 2.68 | 2 | Yes | No | 5 | 5 | 0 | 1 | | R:R:?857 | V:V:K11 | 14.39 | 2 | Yes | Yes | 5 | 9 | 0 | 1 | | R:R:?857 | V:V:R25 | 11.36 | 2 | Yes | Yes | 5 | 9 | 0 | 1 | | R:R:?857 | V:V:K294 | 4.8 | 2 | Yes | No | 5 | 9 | 0 | 1 | | R:R:?859 | R:R:A858 | 2.68 | 9 | No | No | 4 | 5 | 2 | 1 | | R:R:A858 | V:V:K10 | 6.42 | 0 | No | No | 5 | 9 | 1 | 2 | | V:V:F9 | V:V:R25 | 11.76 | 0 | No | Yes | 6 | 9 | 2 | 1 | | V:V:K11 | V:V:V164 | 3.04 | 2 | Yes | Yes | 9 | 8 | 1 | 2 | | V:V:K11 | V:V:L166 | 4.23 | 2 | Yes | No | 9 | 8 | 1 | 2 | | V:V:L166 | V:V:R25 | 9.72 | 0 | No | Yes | 8 | 9 | 2 | 1 | | V:V:L293 | V:V:R25 | 7.29 | 2 | Yes | Yes | 8 | 9 | 2 | 1 | | V:V:E296 | V:V:L293 | 9.28 | 2 | Yes | Yes | 7 | 8 | 2 | 2 | | V:V:E296 | V:V:K294 | 6.75 | 2 | Yes | No | 7 | 9 | 2 | 1 | | V:V:K294 | V:V:R363 | 4.95 | 2 | No | No | 9 | 1 | 1 | 2 | | V:V:E296 | V:V:R363 | 3.49 | 2 | Yes | No | 7 | 1 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 5.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 10.45 | | Average Nodes In Shell | 15.00 | | Average Hubs In Shell | 6.00 | | Average Links In Shell | 18.00 | | Average Links Mediated by Hubs In Shell | 14.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of SEP in 9II2
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?857 | R:R:A858 | 2.68 | 2 | Yes | No | 5 | 5 | 2 | 1 | | R:R:?859 | R:R:A858 | 2.68 | 9 | No | No | 4 | 5 | 0 | 1 | | R:R:A858 | V:V:K10 | 6.42 | 0 | No | No | 5 | 9 | 1 | 2 | | R:R:?859 | R:R:?860 | 17.4 | 9 | No | Yes | 4 | 4 | 0 | 1 | | R:R:?859 | V:V:R7 | 13.43 | 9 | No | No | 4 | 4 | 0 | 1 | | R:R:?860 | R:R:Y861 | 1.93 | 9 | Yes | No | 4 | 4 | 1 | 2 | | R:R:?860 | V:V:R7 | 2 | 9 | Yes | No | 4 | 4 | 1 | 1 | | R:R:?860 | V:V:V8 | 2.45 | 9 | Yes | Yes | 4 | 7 | 1 | 2 | | R:R:?860 | V:V:Y21 | 1.93 | 9 | Yes | Yes | 4 | 8 | 1 | 2 | | R:R:?860 | V:V:K107 | 2.32 | 9 | Yes | No | 4 | 9 | 1 | 2 | | V:V:F9 | V:V:R7 | 7.48 | 0 | No | No | 6 | 4 | 2 | 1 | | V:V:V8 | V:V:Y21 | 2.52 | 9 | Yes | Yes | 7 | 8 | 2 | 2 | | V:V:K10 | V:V:Y21 | 14.33 | 0 | No | Yes | 9 | 8 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 11.17 | | Average Nodes In Shell | 11.00 | | Average Hubs In Shell | 4.00 | | Average Links In Shell | 13.00 | | Average Links Mediated by Hubs In Shell | 9.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of SEP in 9II2
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:?856 | S:S:Q855 | 18.11 | 3 | No | No | 5 | 4 | 0 | 1 | | S:S:?856 | S:S:?857 | 19.02 | 3 | No | Yes | 5 | 5 | 0 | 1 | | S:S:?856 | v:v:K11 | 3.6 | 3 | No | Yes | 5 | 9 | 0 | 1 | | S:S:?857 | S:S:A858 | 2.68 | 3 | Yes | No | 5 | 5 | 1 | 2 | | S:S:?857 | v:v:K11 | 14.39 | 3 | Yes | Yes | 5 | 9 | 1 | 1 | | S:S:?857 | v:v:R25 | 11.36 | 3 | Yes | Yes | 5 | 9 | 1 | 2 | | S:S:?857 | v:v:K294 | 4.8 | 3 | Yes | No | 5 | 9 | 1 | 2 | | v:v:K11 | v:v:V164 | 3.04 | 3 | Yes | Yes | 9 | 8 | 1 | 2 | | v:v:K11 | v:v:L166 | 4.23 | 3 | Yes | No | 9 | 8 | 1 | 2 | | v:v:L166 | v:v:R25 | 9.72 | 0 | No | Yes | 8 | 9 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 13.58 | | Average Nodes In Shell | 9.00 | | Average Hubs In Shell | 4.00 | | Average Links In Shell | 10.00 | | Average Links Mediated by Hubs In Shell | 9.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of SEP in 9II2
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:?856 | S:S:Q855 | 18.11 | 3 | No | No | 5 | 4 | 1 | 2 | | S:S:?856 | S:S:?857 | 19.02 | 3 | No | Yes | 5 | 5 | 1 | 0 | | S:S:?856 | v:v:K11 | 3.6 | 3 | No | Yes | 5 | 9 | 1 | 1 | | S:S:?857 | S:S:A858 | 2.68 | 3 | Yes | No | 5 | 5 | 0 | 1 | | S:S:?857 | v:v:K11 | 14.39 | 3 | Yes | Yes | 5 | 9 | 0 | 1 | | S:S:?857 | v:v:R25 | 11.36 | 3 | Yes | Yes | 5 | 9 | 0 | 1 | | S:S:?857 | v:v:K294 | 4.8 | 3 | Yes | No | 5 | 9 | 0 | 1 | | S:S:?859 | S:S:A858 | 2.68 | 6 | No | No | 4 | 5 | 2 | 1 | | S:S:A858 | v:v:K10 | 6.42 | 0 | No | No | 5 | 9 | 1 | 2 | | v:v:F9 | v:v:R25 | 11.76 | 0 | No | Yes | 6 | 9 | 2 | 1 | | v:v:K11 | v:v:V164 | 3.04 | 3 | Yes | Yes | 9 | 8 | 1 | 2 | | v:v:K11 | v:v:L166 | 4.23 | 3 | Yes | No | 9 | 8 | 1 | 2 | | v:v:L166 | v:v:R25 | 9.72 | 0 | No | Yes | 8 | 9 | 2 | 1 | | v:v:L293 | v:v:R25 | 7.29 | 3 | Yes | Yes | 8 | 9 | 2 | 1 | | v:v:E296 | v:v:L293 | 9.28 | 3 | Yes | Yes | 7 | 8 | 2 | 2 | | v:v:E296 | v:v:K294 | 6.75 | 3 | Yes | No | 7 | 9 | 2 | 1 | | v:v:K294 | v:v:R363 | 4.95 | 3 | No | No | 9 | 1 | 1 | 2 | | v:v:E296 | v:v:R363 | 3.49 | 3 | Yes | No | 7 | 1 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 5.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 10.45 | | Average Nodes In Shell | 15.00 | | Average Hubs In Shell | 6.00 | | Average Links In Shell | 18.00 | | Average Links Mediated by Hubs In Shell | 14.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of SEP in 9II2
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | S:S:?857 | S:S:A858 | 2.68 | 3 | Yes | No | 5 | 5 | 2 | 1 | | S:S:?859 | S:S:A858 | 2.68 | 6 | No | No | 4 | 5 | 0 | 1 | | S:S:A858 | v:v:K10 | 6.42 | 0 | No | No | 5 | 9 | 1 | 2 | | S:S:?859 | S:S:?860 | 17.4 | 6 | No | Yes | 4 | 4 | 0 | 1 | | S:S:?859 | v:v:R7 | 13.43 | 6 | No | No | 4 | 4 | 0 | 1 | | S:S:?860 | S:S:Y861 | 1.93 | 6 | Yes | No | 4 | 4 | 1 | 2 | | S:S:?860 | v:v:R7 | 2 | 6 | Yes | No | 4 | 4 | 1 | 1 | | S:S:?860 | v:v:V8 | 2.45 | 6 | Yes | Yes | 4 | 7 | 1 | 2 | | S:S:?860 | v:v:Y21 | 1.93 | 6 | Yes | Yes | 4 | 8 | 1 | 2 | | S:S:?860 | v:v:K107 | 2.32 | 6 | Yes | No | 4 | 9 | 1 | 2 | | v:v:F9 | v:v:R7 | 7.48 | 0 | No | No | 6 | 4 | 2 | 1 | | v:v:V8 | v:v:Y21 | 2.52 | 6 | Yes | Yes | 7 | 8 | 2 | 2 | | v:v:K10 | v:v:Y21 | 14.33 | 0 | No | Yes | 9 | 8 | 2 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 11.17 | | Average Nodes In Shell | 11.00 | | Average Hubs In Shell | 4.00 | | Average Links In Shell | 13.00 | | Average Links Mediated by Hubs In Shell | 9.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 9II3 | C | Aminoacid | Metabotropic Glutamate | mGlu3; mGlu3 | Homo Sapiens | Glutamate | - | Arrestin2 | 3.9 | 2025-03-05 | doi.org/10.1038/s41589-025-01858-8 |
|
A 2D representation of the interactions of SEP in 9II3
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?856 | R:R:?857 | 20.02 | 7 | No | No | 5 | 5 | 0 | 1 | | R:R:?856 | V:V:K11 | 9.59 | 7 | No | No | 5 | 9 | 0 | 1 | | R:R:?857 | V:V:K11 | 15.59 | 7 | No | No | 5 | 9 | 1 | 1 | | R:R:?857 | V:V:R25 | 8.26 | 7 | No | Yes | 5 | 9 | 1 | 2 | | V:V:K11 | V:V:V164 | 3.04 | 7 | No | Yes | 9 | 8 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 2.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 14.80 | | Average Nodes In Shell | 5.00 | | Average Hubs In Shell | 2.00 | | Average Links In Shell | 5.00 | | Average Links Mediated by Hubs In Shell | 2.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of SEP in 9II3
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?856 | R:R:?857 | 20.02 | 7 | No | No | 5 | 5 | 1 | 0 | | R:R:?856 | V:V:K11 | 9.59 | 7 | No | No | 5 | 9 | 1 | 1 | | R:R:?857 | V:V:K11 | 15.59 | 7 | No | No | 5 | 9 | 0 | 1 | | R:R:?857 | V:V:R25 | 8.26 | 7 | No | Yes | 5 | 9 | 0 | 1 | | V:V:F9 | V:V:R25 | 12.83 | 0 | No | Yes | 6 | 9 | 2 | 1 | | V:V:L166 | V:V:R25 | 10.93 | 0 | No | Yes | 8 | 9 | 2 | 1 | | V:V:L293 | V:V:R25 | 10.93 | 7 | Yes | Yes | 8 | 9 | 2 | 1 | | V:V:H362 | V:V:R25 | 5.64 | 7 | Yes | Yes | 1 | 9 | 2 | 1 | | V:V:H362 | V:V:L293 | 9 | 7 | Yes | Yes | 1 | 8 | 2 | 2 | | V:V:K11 | V:V:V164 | 3.04 | 7 | No | Yes | 9 | 8 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 1.00 | | Average Interaction Strength | 14.62 | | Average Nodes In Shell | 9.00 | | Average Hubs In Shell | 4.00 | | Average Links In Shell | 10.00 | | Average Links Mediated by Hubs In Shell | 7.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of SEP in 9II3
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?859 | R:R:A858 | 4.02 | 0 | No | No | 4 | 5 | 0 | 1 | | R:R:?859 | R:R:?860 | 28.03 | 0 | No | No | 4 | 4 | 0 | 1 | | R:R:?859 | V:V:R7 | 13.43 | 0 | No | No | 4 | 4 | 0 | 1 | | R:R:?860 | V:V:K107 | 13.89 | 0 | No | No | 4 | 9 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 3.00 | | Average Number Of Links With An Hub | 0.00 | | Average Interaction Strength | 15.16 | | Average Nodes In Shell | 5.00 | | Average Hubs In Shell | 0.00 | | Average Links In Shell | 4.00 | | Average Links Mediated by Hubs In Shell | 0.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
| Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 9M0D | A | Peptide | Neurotensin | NTS1 | Homo Sapiens | - | - | Arrestin2 | 3.41 | 2025-04-09 | doi.org/10.1038/s41422-025-01095-7 |
|
A 2D representation of the interactions of SEP in 9M0D
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?407 | R:R:L408 | 4.55 | 1 | Yes | No | 7 | 3 | 2 | 1 | | R:R:?409 | R:R:L408 | 4.71 | 1 | Yes | No | 6 | 3 | 0 | 1 | | R:R:L408 | V:V:K10 | 5.64 | 1 | No | Yes | 3 | 9 | 1 | 1 | | R:R:?409 | R:R:?410 | 17.02 | 1 | Yes | Yes | 6 | 6 | 0 | 1 | | R:R:?409 | V:V:R7 | 17.56 | 1 | Yes | No | 6 | 4 | 0 | 1 | | R:R:?409 | V:V:K10 | 6 | 1 | Yes | Yes | 6 | 9 | 0 | 1 | | R:R:?410 | R:R:N411 | 10.51 | 1 | Yes | No | 6 | 6 | 1 | 2 | | R:R:?410 | V:V:V8 | 3.8 | 1 | Yes | No | 6 | 7 | 1 | 2 | | R:R:?410 | V:V:K10 | 6 | 1 | Yes | Yes | 6 | 9 | 1 | 1 | | R:R:?410 | V:V:K107 | 9.59 | 1 | Yes | No | 6 | 9 | 1 | 2 | | V:V:K10 | V:V:Y21 | 15.53 | 1 | Yes | Yes | 9 | 8 | 1 | 2 | | V:V:R7 | V:V:T6 | 1.29 | 0 | No | No | 4 | 4 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 4.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 11.32 | | Average Nodes In Shell | 11.00 | | Average Hubs In Shell | 5.00 | | Average Links In Shell | 12.00 | | Average Links Mediated by Hubs In Shell | 11.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
|
A 2D representation of the interactions of SEP in 9M0D
colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | | R:R:?409 | R:R:L408 | 4.71 | 1 | Yes | No | 6 | 3 | 1 | 2 | | R:R:L408 | V:V:K10 | 5.64 | 1 | No | Yes | 3 | 9 | 2 | 1 | | R:R:?409 | R:R:?410 | 17.02 | 1 | Yes | Yes | 6 | 6 | 1 | 0 | | R:R:?409 | V:V:R7 | 17.56 | 1 | Yes | No | 6 | 4 | 1 | 2 | | R:R:?409 | V:V:K10 | 6 | 1 | Yes | Yes | 6 | 9 | 1 | 1 | | R:R:?410 | R:R:N411 | 10.51 | 1 | Yes | No | 6 | 6 | 0 | 1 | | R:R:?410 | V:V:V8 | 3.8 | 1 | Yes | No | 6 | 7 | 0 | 1 | | R:R:?410 | V:V:K10 | 6 | 1 | Yes | Yes | 6 | 9 | 0 | 1 | | R:R:?410 | V:V:K107 | 9.59 | 1 | Yes | No | 6 | 9 | 0 | 1 | | V:V:L104 | V:V:V8 | 7.45 | 1 | Yes | No | 9 | 7 | 2 | 1 | | V:V:K10 | V:V:Y21 | 15.53 | 1 | Yes | Yes | 9 | 8 | 1 | 2 | | V:V:L104 | V:V:Y21 | 4.69 | 1 | Yes | Yes | 9 | 8 | 2 | 2 | | V:V:L108 | V:V:Y21 | 9.38 | 1 | Yes | Yes | 8 | 8 | 2 | 2 | | V:V:L104 | V:V:L108 | 4.15 | 1 | Yes | Yes | 9 | 8 | 2 | 2 | | V:V:K107 | V:V:L108 | 5.64 | 0 | No | Yes | 9 | 8 | 1 | 2 | |
| Statistics | Value |
|---|
| Average Number Of Links | 5.00 | | Average Number Of Links With An Hub | 2.00 | | Average Interaction Strength | 9.38 | | Average Nodes In Shell | 11.00 | | Average Hubs In Shell | 6.00 | | Average Links In Shell | 15.00 | | Average Links Mediated by Hubs In Shell | 15.00 |
| 
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | 
Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
