Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:L6 7.342510
2R:R:Y70 4.985437
3R:R:F74 4.3975407
4R:R:L94 12.7025425
5R:R:T100 4.975407
6R:R:H104 6.0075468
7R:R:D112 6.53409
8R:R:M120 5.198538
9R:R:E123 7.41333616
10R:R:F127 6.73167614
11R:R:W129 6.1975405
12R:R:W134 10.36518
13R:R:F136 4.89517
14R:R:Y144 5.988516
15R:R:F146 4.8125406
16R:R:N158 5.534588
17R:R:Y167 6.212508
18R:R:W193 4.836589
19R:R:T206 4.7725405
20R:R:M207 8.1525406
21R:R:N211 5.1402
22R:R:P226 6.5975405
23R:R:P248 3.93409
24R:R:V302 2.99407
25R:R:W316 7.238598
26R:R:Y319 7.612516
27R:R:H320 7.5875407
28R:R:R322 7.89715
29R:R:R323 9.6625416
30R:R:W334 8.09514
31R:R:Y339 10.822512
32R:R:Y342 8.0175414
33R:R:Y346 9.164514
34R:R:T349 5.8575416
35R:R:N350 6.698516
36R:R:Y364 6.07667679
37R:R:F371 7.23558
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:P3 R:R:Y339 14.93335.56NoYes102
2L:L:P3 R:R:Y342 15.16159.74NoYes104
3R:R:R322 R:R:Y346 28.603711.32YesYes154
4R:R:R322 R:R:Y342 22.150811.32YesYes154
5R:R:M207 R:R:P226 29.496410.06YesYes065
6R:R:P226 R:R:T225 31.535.25YesNo054
7R:R:R212 R:R:T225 30.132911.64NoNo014
8R:R:Q210 R:R:R212 28.85998.18NoNo011
9R:R:Q210 R:R:T227 27.45495.67NoNo013
10R:R:G208 R:R:T227 26.04583.64NoNo043
11R:R:G208 R:R:R142 24.63276NoNo047
12R:R:D138 R:R:R142 23.215614.29NoNo037
13R:R:D138 R:R:E209 21.79465.2NoNo035
14R:R:E209 R:R:L222 18.940410.6NoNo054
15R:R:L222 R:R:N211 17.50738.24NoYes042
16R:R:G221 R:R:N211 10.28183.39NoYes022
17R:R:V56 R:R:Y339 11.09245.05NoYes122
18R:R:H131 R:R:V56 10.431919.37NoNo032
19R:R:E123 R:R:Y346 29.01415.61YesYes164
20R:R:E123 R:R:Y354 90.018411.22YesNo067
21R:R:M120 R:R:Y354 13.05797.18YesNo087
22R:R:F353 R:R:Y354 91.21535.16NoNo077
23R:R:F353 R:R:W316 90.869112.03NoYes978
24R:R:S356 R:R:W316 12.21538.65NoYes098
25R:R:T155 R:R:W316 1004.85NoYes098
26R:R:D112 R:R:T155 89.74627.23YesNo099
27R:R:D112 R:R:L108 44.84415.43YesNo099
28R:R:L108 R:R:Y364 48.16067.03NoYes099
29R:R:L162 R:R:Y364 32.26654.69NoYes799
30R:R:L105 R:R:L162 31.24774.15NoNo089
31R:R:L105 R:R:N365 30.14295.49NoNo087
32R:R:F371 R:R:N365 22.046813.29YesNo587
33R:R:D112 R:R:N360 44.7269.42YesNo099
34R:R:N360 R:R:Y364 44.40986.98NoYes099
35R:R:F371 R:R:T87 14.17687.78YesNo087
36R:R:I374 R:R:T87 13.01793.04NoNo067
37R:R:I374 R:R:K91 11.8552.91NoNo065
38R:R:S111 R:R:T155 10.19374.8NoNo089
39R:R:E123 R:R:Y144 22.46114.49YesYes166
40R:R:M207 R:R:Y145 39.085710.78YesNo064
41R:R:F127 R:R:Y145 20.47765.16YesNo144
42R:R:M207 R:R:T206 16.97897.53YesYes065
43R:R:F205 R:R:T206 11.38273.89NoYes045
44R:R:N240 R:R:R323 17.675414.46NoYes066
45R:R:N240 R:R:Y153 11.07649.3NoNo067
46R:R:H320 R:R:Y319 12.78976.53YesYes076
47R:R:F245 R:R:H320 12.05324.53NoYes087
48R:R:F245 R:R:M249 11.56687.46NoNo086
49R:R:F312 R:R:M249 11.42674.98NoNo096
50R:R:V159 R:R:Y364 55.36215.05NoYes089
51R:R:I252 R:R:V159 54.35133.07NoNo088
52R:R:I252 R:R:V309 53.33054.61NoNo088
53R:R:N256 R:R:V309 49.20744.43NoNo098
54R:R:N256 R:R:S163 23.49395.96NoNo099
55R:R:L255 R:R:S163 22.4036.01NoNo079
56R:R:L255 R:R:Y167 20.225410.55NoYes078
57R:R:C171 R:R:Y167 29.36036.72NoYes078
58R:R:L305 R:R:N256 24.69489.61NoNo089
59R:R:I259 R:R:L305 23.59994.28NoNo098
60R:R:I259 R:R:Y167 20.40553.63NoYes098
61R:R:C171 R:R:K262 27.09863.23NoNo075
62R:R:K262 R:R:M266 24.91094.32NoNo056
63R:R:L263 R:R:M266 20.37552.83NoNo086
64R:R:L263 R:R:V302 11.40474.47NoYes087
65R:R:V308 R:R:Y364 11.8557.57NoYes089
66R:R:L363 R:R:V308 10.67811.49NoNo088
67R:R:E123 R:R:F127 27.17474.66YesYes164
68R:R:F312 R:R:W316 12.92787.02NoYes098
69R:R:Y144 R:R:Y145 19.48485.96YesNo164
70R:R:R323 R:R:Y319 15.65398.23YesYes166
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:K1 R:R:Y339 22.69 0 No Yes 0 2 0 1
L:L:K2 R:R:W334 6.96 0 No Yes 0 4 0 1
L:L:P3 R:R:W334 13.51 1 No Yes 0 4 0 1
L:L:P3 R:R:Y339 5.56 1 No Yes 0 2 0 1
L:L:P3 R:R:Y342 9.74 1 No Yes 0 4 0 1
L:L:Y4 R:R:L54 5.86 0 No No 0 5 0 1
L:L:Y4 R:R:V223 15.14 0 No No 0 4 0 1
L:L:I5 R:R:F127 10.05 1 No Yes 0 4 0 1
L:L:I5 R:R:Y346 6.04 1 No Yes 0 4 0 1
L:L:L6 R:R:M207 4.24 1 Yes Yes 0 6 0 1
L:L:L6 R:R:I237 5.71 1 Yes No 0 6 0 1
L:L:L6 R:R:R322 4.86 1 Yes Yes 0 5 0 1
L:L:L6 R:R:R323 8.5 1 Yes Yes 0 6 0 1
L:L:L6 R:R:F326 13.4 1 Yes No 0 4 0 1
R:R:H132 R:R:L54 7.71 0 No No 4 5 2 1
R:R:V56 R:R:Y339 5.05 1 No Yes 2 2 2 1
R:R:H343 R:R:V56 16.61 1 No No 4 2 2 2
R:R:E123 R:R:F127 4.66 1 Yes Yes 6 4 2 1
R:R:E123 R:R:Y144 4.49 1 Yes Yes 6 6 2 2
R:R:E123 R:R:Y346 5.61 1 Yes Yes 6 4 2 1
R:R:E123 R:R:N350 9.2 1 Yes Yes 6 6 2 2
R:R:F127 R:R:W134 4.01 1 Yes Yes 4 8 1 2
R:R:F127 R:R:Y144 4.13 1 Yes Yes 4 6 1 2
R:R:F127 R:R:Y145 5.16 1 Yes No 4 4 1 2
R:R:F127 R:R:Y346 12.38 1 Yes Yes 4 4 1 1
R:R:Y144 R:R:Y145 5.96 1 Yes No 6 4 2 2
R:R:M207 R:R:Y145 10.78 0 Yes No 6 4 1 2
R:R:M207 R:R:T206 7.53 0 Yes Yes 6 5 1 2
R:R:M207 R:R:P226 10.06 0 Yes Yes 6 5 1 2
R:R:F326 R:R:P226 5.78 0 No Yes 4 5 1 2
R:R:C327 R:R:I237 8.18 0 No No 3 6 2 1
R:R:N240 R:R:R323 14.46 0 No Yes 6 6 2 1
R:R:R322 R:R:Y319 8.23 1 Yes Yes 5 6 1 2
R:R:R323 R:R:Y319 8.23 1 Yes Yes 6 6 1 2
R:R:N350 R:R:Y319 5.81 1 Yes Yes 6 6 2 2
R:R:R322 R:R:R323 7.46 1 Yes Yes 5 6 1 1
R:R:R322 R:R:Y342 11.32 1 Yes Yes 5 4 1 1
R:R:F345 R:R:R322 4.28 1 No Yes 4 5 2 1
R:R:R322 R:R:Y346 11.32 1 Yes Yes 5 4 1 1
R:R:R322 R:R:T349 7.76 1 Yes Yes 5 6 1 2
R:R:F326 R:R:Y342 6.19 0 No Yes 4 4 1 1
R:R:I329 R:R:W334 11.74 0 No Yes 3 4 2 1
R:R:W334 R:R:Y342 4.82 1 Yes Yes 4 4 1 1
R:R:H343 R:R:Y339 18.51 1 No Yes 4 2 2 1
R:R:F345 R:R:T349 7.78 1 No Yes 4 6 2 2
R:R:N350 R:R:Y346 10.47 1 Yes Yes 6 4 2 1
R:R:N350 R:R:T349 4.39 1 Yes Yes 6 6 2 2
R:R:L338 R:R:W334 3.42 0 No Yes 1 4 2 1
R:R:D340 R:R:Y339 2.3 0 No Yes 1 2 2 1
L:L:K2 R:R:T230 1.5 0 No No 0 4 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 6OS9_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.44
Number of Linked Nodes 286
Number of Links 309
Number of Hubs 37
Number of Links mediated by Hubs 145
Number of Communities 9
Number of Nodes involved in Communities 52
Number of Links involved in Communities 68
Path Summary
Number Of Nodes in MetaPath 71
Number Of Links MetaPath 70
Number of Shortest Paths 78378
Length Of Smallest Path 3
Average Path Length 17.6324
Length of Longest Path 41
Minimum Path Strength 1.28
Average Path Strength 6.65142
Maximum Path Strength 20.6
Minimum Path Correlation 0.7
Average Path Correlation 0.930336
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.84615
Average % Of Corr. Nodes 46.6179
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 35.739
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
SCOP2Family Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP30989
Sequence
>6OS9_nogp_Chain_R
PSSELDVNT DIYSKVLVT AVYLALFVV GTVGNTVTL FTLARKKSL 
QSLQSTVHY HLGSLALSD LLTLLLAMP VELYNFIWV HHPWAFGDA 
GCRGYYFLR DACTYATAL NVASLSVER YLAICHPFK AKTLMSRSR 
TKKFISAIW LASALLAVP MLFTMGEQN RSADGQHAG GLVCTPTIH 
TATVKVVIQ VNTFMSFIF PMVVISVLN TIIANKLTV MVRQAAEQR 
VQALRHGVR VLRAVVIAF VVCWLPYHV RRLMFCYIS DEQWTPFLY 
DFYHYFYMV TNALFYVSS TINPILYNL VSANFRHIF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
4GRVAPeptideNeurotensinNTS1Rattus norvegicusNeurotensin-(8-13)--2.82012-10-17doi.org/10.1038/nature11558
3ZEVAPeptideNeurotensinNTS1Rattus norvegicusNeurotensin-(7-13)--32014-01-29doi.org/10.1073/pnas.1317903111
4BUOAPeptideNeurotensinNTS1Rattus norvegicusNeurotensin-(8-13)--2.752014-01-29doi.org/10.1073/pnas.1317903111
4BV0APeptideNeurotensinNTS1Rattus norvegicusNeurotensin-(7-13)--3.12014-01-29doi.org/10.1073/pnas.1317903111
4BWBAPeptideNeurotensinNTS1Rattus norvegicusNeurotensin-(8-12)--3.572014-01-29doi.org/10.1073/pnas.1317903111
4XEEAPeptideNeurotensinNTS1Rattus norvegicusNeurotensin-(8-13)--2.92015-07-29doi.org/10.1038/ncomms8895
4XESAPeptideNeurotensinNTS1Rattus norvegicusNeurotensin-(8-13)--2.62015-07-29doi.org/10.1038/ncomms8895
5T04APeptideNeurotensinNTS1Rattus norvegicusNeurotensin-(8-13)--3.32016-12-21doi.org/10.1038/srep38564
6OS9APeptideNeurotensinNTS1Homo sapiensJMV449-Gi1/β1/γ232019-07-10doi.org/10.1038/s41586-019-1337-6
6OS9 (No Gprot) APeptideNeurotensinNTS1Homo sapiensJMV449-32019-07-10doi.org/10.1038/s41586-019-1337-6
6OSAAPeptideNeurotensinNTS1Homo sapiensJMV449-Gi1/β1/γ232019-07-10doi.org/10.1038/s41586-019-1337-6
6OSA (No Gprot) APeptideNeurotensinNTS1Homo sapiensJMV449-32019-07-10doi.org/10.1038/s41586-019-1337-6
6PWCAPeptideNeurotensinNTS1Homo sapiensNeurotensin-(9-13)-Arrestin24.92019-12-04doi.org/10.1038/s41422-019-0256-2
6UP7APeptideNeurotensinNTS1Homo sapiensNeurotensin-(8-13)-Arrestin24.22020-02-26doi.org/10.1038/s41586-020-1953-1
7L0PAPeptideNeurotensinNTS1Rattus norvegicusNeurotensin-(8-13)-Gi1/β1/γ14.12021-01-06doi.org/10.1038/s41594-020-00554-6
7L0P (No Gprot) APeptideNeurotensinNTS1Rattus norvegicusNeurotensin-(8-13)-4.12021-01-06doi.org/10.1038/s41594-020-00554-6
7L0QAPeptideNeurotensinNTS1Rattus norvegicusNeurotensin-(8-13)-Gi1/β1/γ14.32021-01-06doi.org/10.1038/s41594-020-00554-6
7L0Q (No Gprot) APeptideNeurotensinNTS1Rattus norvegicusNeurotensin-(8-13)-4.32021-01-06doi.org/10.1038/s41594-020-00554-6
7L0RAPeptideNeurotensinNTS1Rattus norvegicusNeurotensin-(8-13)-Gi1/β1/γ14.22021-01-06doi.org/10.1038/s41594-020-00554-6
7L0R (No Gprot) APeptideNeurotensinNTS1Rattus norvegicusNeurotensin-(8-13)-4.22021-01-06doi.org/10.1038/s41594-020-00554-6
7L0SAPeptideNeurotensinNTS1Rattus norvegicusNeurotensin-(8-13)-Gi1/β1/γ14.52021-01-06doi.org/10.1038/s41594-020-00554-6
7L0S (No Gprot) APeptideNeurotensinNTS1Rattus norvegicusNeurotensin-(8-13)-4.52021-01-06doi.org/10.1038/s41594-020-00554-6
6YVRAPeptideNeurotensinNTS1Rattus norvegicusNeurotensin-(6-13)--2.462021-02-10doi.org/10.1126/sciadv.abe5504
6Z4QAPeptideNeurotensinNTS1Rattus norvegicusSR142948A--2.922021-02-10doi.org/10.1126/sciadv.abe5504
6Z4SAPeptideNeurotensinNTS1Rattus norvegicusSR48692--2.712021-02-10doi.org/10.1126/sciadv.abe5504
6Z4VAPeptideNeurotensinNTS1Rattus norvegicusNeurotensin-(9-13)--2.62021-02-10doi.org/10.1126/sciadv.abe5504
6Z66APeptideNeurotensinNTS1Rattus norvegicus---3.192021-02-10doi.org/10.1126/sciadv.abe5504
6Z8NAPeptideNeurotensinNTS1Rattus norvegicusSRI-9829--2.82021-02-10doi.org/10.1126/sciadv.abe5504
6ZA8APeptideNeurotensinNTS1Rattus norvegicusRTI-3a--2.722021-02-10doi.org/10.1126/sciadv.abe5504
6ZINAPeptideNeurotensinNTS1Rattus norvegicusSR48692--2.642021-02-10doi.org/10.1126/sciadv.abe5504
7UL2APeptideNeurotensinNTS1Homo sapiensSR48692Na-2.42022-06-29doi.org/10.1038/s41594-022-00859-8
8FMZAPeptideNeurotensinNTS1Rattus norvegicusNeurotensin-(8-13)-chim(NtGi2L-Gs-CtGq)/β1/γ22.592023-03-29doi.org/10.1021/acs.biochem.3c00029
8FMZ (No Gprot) APeptideNeurotensinNTS1Rattus norvegicusNeurotensin-(8-13)-2.592023-03-29doi.org/10.1021/acs.biochem.3c00029
8FN0APeptideNeurotensinNTS1Rattus norvegicusNeurotensin-(8-13)SBI-553chim(NtGi1-Go)/β1/γ22.892023-03-29doi.org/10.1021/acs.biochem.3c00029
8FN0 (No Gprot) APeptideNeurotensinNTS1Rattus norvegicusNeurotensin-(8-13)SBI-5532.892023-03-29doi.org/10.1021/acs.biochem.3c00029
8FN1APeptideNeurotensinNTS1Rattus norvegicusNeurotensin-(8-13)-chim(NtGi1-Go)/β1/γ22.882023-03-29doi.org/10.1021/acs.biochem.3c00029
8FN1 (No Gprot) APeptideNeurotensinNTS1Rattus norvegicusNeurotensin-(8-13)-2.882023-03-29doi.org/10.1021/acs.biochem.3c00029
8JPBAPeptideNeurotensinNTS1Homo sapiensNeurotensin-(8-13)SBI-553; GDP; MgGq; GRK23.072023-08-09doi.org/10.1038/s41586-023-06395-9
8JPB (No Gprot) APeptideNeurotensinNTS1Homo sapiensNeurotensin-(8-13)SBI-553; GDP; Mg3.072023-08-09doi.org/10.1038/s41586-023-06395-9
8JPCAPeptideNeurotensinNTS1Homo sapiensNeurotensin-(8-13)SBI-553; GDP; MgGq; GRK23.072023-08-09doi.org/10.1038/s41586-023-06395-9
8JPC (No Gprot) APeptideNeurotensinNTS1Homo sapiensNeurotensin-(8-13)SBI-553; GDP; Mg3.072023-08-09doi.org/10.1038/s41586-023-06395-9
8JPFAPeptideNeurotensinNTS1Homo sapiensNeurotensin-(8-13)SBI-553-3.022023-08-09doi.org/10.1038/s41586-023-06395-9
8ZYTAPeptideNeurotensinNTS1Homo sapiensNeurotensin-(8-13)SBI-553Arrestin22.652025-04-09doi.org/10.1038/s41422-025-01095-7
8ZYYAPeptideNeurotensinNTS1Homo sapiensNeurotensin-(8-13)SBI-553Arrestin22.832025-04-09doi.org/10.1038/s41422-025-01095-7
9M0DAPeptideNeurotensinNTS1Homo sapiens--Arrestin23.412025-04-09doi.org/10.1038/s41422-025-01095-7
8ZYUAPeptideNeurotensinNTS1Homo sapiensNeurotensin-(8-13)SBI-553Arrestin22.652025-04-16doi.org/10.1038/s41422-025-01095-7




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