psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:K1	R:R:Y339	22.69	No	Yes	0	0	2
2	L:L:K2	R:R:W334	6.96	No	Yes	0	0	4
3	L:L:P3	R:R:W334	13.51	No	Yes	1	0	4
4	L:L:P3	R:R:Y339	5.56	No	Yes	1	0	2
5	L:L:P3	R:R:Y342	9.74	No	Yes	1	0	4
6	L:L:I5	L:L:Y4	4.84	No	No	0	0	0
7	L:L:Y4	R:R:L54	5.86	No	No	0	0	5
8	L:L:Y4	R:R:V223	15.14	No	No	0	0	4
9	L:L:I5	R:R:F127	10.05	No	Yes	1	0	4
10	L:L:I5	R:R:Y346	6.04	No	Yes	1	0	4
11	L:L:L6	R:R:M207	4.24	Yes	Yes	0	0	6
12	L:L:L6	R:R:I237	5.71	Yes	No	0	0	6
13	L:L:L6	R:R:R322	4.86	Yes	Yes	1	0	5
14	L:L:L6	R:R:R323	8.5	Yes	Yes	1	0	6
15	L:L:L6	R:R:F326	13.4	Yes	No	0	0	4
16	R:R:P50	R:R:S52	7.13	No	No	0	4	6
17	R:R:H218	R:R:S51	8.37	No	No	0	3	3
18	R:R:G221	R:R:S51	3.71	No	No	0	2	3
19	R:R:H132	R:R:L54	7.71	No	No	0	4	5
20	R:R:D55	R:R:H132	11.35	No	No	0	3	4
21	R:R:H131	R:R:V56	19.37	No	No	0	3	2
22	R:R:V56	R:R:Y339	5.05	No	Yes	1	2	2
23	R:R:H343	R:R:V56	16.61	No	No	1	4	2
24	R:R:D340	R:R:N57	8.08	No	No	0	1	2
25	R:R:K63	R:R:T58	7.51	No	No	0	5	1
26	R:R:T58	R:R:Y344	4.99	No	No	0	1	1
27	R:R:D59	R:R:S62	5.89	No	No	0	3	3
28	R:R:D59	R:R:Y344	10.34	No	No	0	3	1
29	R:R:I60	R:R:Y61	3.63	No	No	0	2	2
30	R:R:K63	R:R:W129	12.76	No	Yes	0	5	5
31	R:R:V66	R:R:Y70	8.83	No	Yes	0	5	7
32	R:R:M347	R:R:V66	10.65	No	No	0	3	5
33	R:R:T67	R:R:W129	7.28	No	Yes	0	6	5
34	R:R:M120	R:R:Y70	3.59	Yes	Yes	3	8	7
35	R:R:L124	R:R:Y70	3.52	No	Yes	3	6	7
36	R:R:A351	R:R:Y70	4	No	Yes	0	5	7
37	R:R:L73	R:R:T358	7.37	No	No	0	7	7
38	R:R:F74	R:R:T78	5.19	Yes	No	0	7	6
39	R:R:F74	R:R:L116	4.87	Yes	No	0	7	7
40	R:R:F74	R:R:M120	6.22	Yes	Yes	0	7	8
41	R:R:G77	R:R:T358	3.64	No	No	0	8	7
42	R:R:D112	R:R:N81	4.04	Yes	No	0	9	9
43	R:R:N81	R:R:P361	6.52	No	No	0	9	9
44	R:R:F375	R:R:V83	6.55	No	No	0	7	6
45	R:R:N365	R:R:T84	8.77	No	No	5	7	9
46	R:R:F371	R:R:T84	5.19	Yes	No	5	8	9
47	R:R:F86	R:R:R90	13.9	No	No	0	4	5
48	R:R:F371	R:R:T87	7.78	Yes	No	0	8	7
49	R:R:H102	R:R:L88	5.14	No	No	0	8	7
50	R:R:K91	R:R:S93	4.59	No	No	0	5	6
51	R:R:K91	R:R:L94	5.64	No	Yes	0	5	5
52	R:R:L94	R:R:Q98	23.96	Yes	No	2	5	7
53	R:R:L94	R:R:S99	4.5	Yes	No	2	5	8
54	R:R:H102	R:R:L94	16.71	No	Yes	2	8	5
55	R:R:Q98	R:R:S96	8.66	No	No	0	7	6
56	R:R:K177	R:R:L97	5.64	No	No	0	4	8
57	R:R:L97	R:R:M180	5.65	No	No	0	8	7
58	R:R:H102	R:R:Q98	7.42	No	No	2	8	7
59	R:R:S99	R:R:Y103	5.09	No	No	2	8	5
60	R:R:R182	R:R:S99	9.22	No	No	2	3	8
61	R:R:E165	R:R:T100	4.23	No	Yes	0	8	7
62	R:R:T100	R:R:T185	10.99	Yes	No	0	7	7
63	R:R:R182	R:R:Y103	9.26	No	No	2	3	5
64	R:R:K186	R:R:Y103	7.17	No	No	0	3	5
65	R:R:H104	R:R:S161	5.58	Yes	No	6	8	7
66	R:R:E165	R:R:H104	8.62	No	Yes	0	8	8
67	R:R:F188	R:R:H104	4.53	No	Yes	6	6	8
68	R:R:H104	R:R:I189	5.3	Yes	No	0	8	7
69	R:R:L105	R:R:L162	4.15	No	No	0	8	9
70	R:R:L105	R:R:N365	5.49	No	No	0	8	7
71	R:R:N158	R:R:S107	8.94	Yes	No	8	8	9
72	R:R:I189	R:R:S107	4.64	No	No	0	7	9
73	R:R:S107	R:R:W193	6.18	No	Yes	8	9	9
74	R:R:D112	R:R:L108	5.43	Yes	No	0	9	9
75	R:R:L108	R:R:N158	5.49	No	Yes	0	9	8
76	R:R:L108	R:R:Y364	7.03	No	Yes	0	9	9
77	R:R:S111	R:R:T155	4.8	No	No	0	8	9
78	R:R:N158	R:R:S111	4.47	Yes	No	0	8	8
79	R:R:D112	R:R:T155	7.23	Yes	No	0	9	9
80	R:R:D112	R:R:N360	9.42	Yes	No	0	9	9
81	R:R:L113	R:R:L117	6.92	No	No	4	7	5
82	R:R:S357	R:R:T115	6.4	No	No	0	9	7
83	R:R:L118	R:R:L147	6.92	No	No	0	5	5
84	R:R:A119	R:R:Y144	4	No	Yes	0	7	6
85	R:R:L124	R:R:M120	5.65	No	Yes	3	6	8
86	R:R:M120	R:R:Y354	7.18	Yes	No	0	8	7
87	R:R:F136	R:R:V122	3.93	Yes	No	0	7	6
88	R:R:V122	R:R:Y144	11.36	No	Yes	0	6	6
89	R:R:E123	R:R:F127	4.66	Yes	Yes	1	6	4
90	R:R:E123	R:R:Y144	4.49	Yes	Yes	1	6	6
91	R:R:E123	R:R:R148	9.3	Yes	No	1	6	7
92	R:R:E123	R:R:Y346	5.61	Yes	Yes	1	6	4
93	R:R:E123	R:R:N350	9.2	Yes	Yes	1	6	6
94	R:R:E123	R:R:Y354	11.22	Yes	No	0	6	7
95	R:R:N126	R:R:Y125	5.81	No	No	0	5	5
96	R:R:V130	R:R:Y125	8.83	No	No	0	5	5
97	R:R:N126	R:R:W134	9.04	No	Yes	1	5	8
98	R:R:F136	R:R:N126	4.83	Yes	No	1	7	5
99	R:R:F127	R:R:W134	4.01	Yes	Yes	1	4	8
100	R:R:F127	R:R:Y144	4.13	Yes	Yes	1	4	6
101	R:R:F127	R:R:Y145	5.16	Yes	No	1	4	4
102	R:R:F127	R:R:Y346	12.38	Yes	Yes	1	4	4
103	R:R:I128	R:R:W129	3.52	No	Yes	0	4	5
104	R:R:G220	R:R:P133	6.09	No	No	0	5	5
105	R:R:F136	R:R:W134	10.02	Yes	Yes	1	7	8
106	R:R:C141	R:R:W134	9.14	No	Yes	1	9	8
107	R:R:C224	R:R:W134	19.59	No	Yes	1	9	8
108	R:R:A135	R:R:F136	4.16	No	Yes	0	3	7
109	R:R:E209	R:R:G137	4.91	No	No	0	5	8
110	R:R:D138	R:R:R142	14.29	No	No	0	3	7
111	R:R:D138	R:R:E209	5.2	No	No	0	3	5
112	R:R:C141	R:R:C224	7.28	No	No	1	9	9
113	R:R:G208	R:R:R142	6	No	No	0	4	7
114	R:R:Y144	R:R:Y145	5.96	Yes	No	1	6	4
115	R:R:M207	R:R:Y145	10.78	Yes	No	0	6	4
116	R:R:A200	R:R:F146	4.16	No	Yes	0	7	6
117	R:R:F146	R:R:L204	10.96	Yes	No	0	6	5
118	R:R:R148	R:R:Y319	9.26	No	Yes	1	7	6
119	R:R:N350	R:R:R148	3.62	Yes	No	1	6	7
120	R:R:D149	R:R:M203	9.7	No	No	0	5	5
121	R:R:D149	R:R:N240	4.04	No	No	0	5	6
122	R:R:T152	R:R:W316	3.64	No	Yes	9	7	8
123	R:R:F353	R:R:T152	7.78	No	No	9	7	7
124	R:R:L199	R:R:Y153	14.07	No	No	0	6	7
125	R:R:N240	R:R:Y153	9.3	No	No	0	6	7
126	R:R:M243	R:R:Y153	4.79	No	No	0	5	7
127	R:R:A154	R:R:W193	7.78	No	Yes	0	7	9
128	R:R:T155	R:R:W316	4.85	No	Yes	0	9	8
129	R:R:A156	R:R:P248	3.74	No	Yes	0	8	9
130	R:R:L157	R:R:S196	4.5	No	No	0	6	8
131	R:R:I192	R:R:N158	4.25	No	Yes	0	7	8
132	R:R:N158	R:R:W193	4.52	Yes	Yes	8	8	9
133	R:R:V159	R:R:Y364	5.05	No	Yes	0	8	9
134	R:R:F188	R:R:S161	5.28	No	No	6	6	7
135	R:R:L162	R:R:R166	3.64	No	No	7	9	9
136	R:R:L162	R:R:Y364	4.69	No	Yes	7	9	9
137	R:R:L255	R:R:S163	6.01	No	No	0	7	9
138	R:R:N256	R:R:S163	5.96	No	No	0	9	9
139	R:R:R166	R:R:Y364	5.14	No	Yes	7	9	9
140	R:R:C171	R:R:Y167	6.72	No	Yes	0	7	8
141	R:R:H172	R:R:Y167	6.53	No	Yes	0	6	8
142	R:R:L255	R:R:Y167	10.55	No	Yes	0	7	8
143	R:R:I258	R:R:Y167	3.63	No	Yes	0	5	8
144	R:R:I259	R:R:Y167	3.63	No	Yes	0	9	8
145	R:R:I170	R:R:I259	4.42	No	No	0	9	9
146	R:R:R184	R:R:S181	9.22	No	No	0	5	8
147	R:R:P202	R:R:V201	3.53	No	No	0	7	5
148	R:R:F205	R:R:T206	3.89	No	Yes	0	4	5
149	R:R:M207	R:R:T206	7.53	Yes	Yes	0	6	5
150	R:R:I228	R:R:T206	6.08	No	Yes	0	5	5
151	R:R:M207	R:R:P226	10.06	Yes	Yes	0	6	5
152	R:R:G208	R:R:T227	3.64	No	No	0	4	3
153	R:R:E209	R:R:L222	10.6	No	No	0	5	4
154	R:R:Q210	R:R:R212	8.18	No	No	0	1	1
155	R:R:Q210	R:R:T227	5.67	No	No	0	1	3
156	R:R:N211	R:R:S213	7.45	Yes	No	0	2	1
157	R:R:L222	R:R:N211	8.24	No	Yes	0	4	2
158	R:R:R212	R:R:T225	11.64	No	No	0	1	4
159	R:R:D215	R:R:G216	5.03	No	No	0	2	2
160	R:R:P226	R:R:T225	5.25	Yes	No	0	5	4
161	R:R:P226	R:R:V233	5.3	Yes	No	0	5	5
162	R:R:F326	R:R:P226	5.78	No	Yes	0	4	5
163	R:R:K234	R:R:Y328	4.78	No	No	0	4	5
164	R:R:C327	R:R:I237	8.18	No	No	0	3	6
165	R:R:N240	R:R:R323	14.46	No	Yes	0	6	6
166	R:R:H320	R:R:T241	12.32	Yes	No	0	7	6
167	R:R:L324	R:R:T241	7.37	No	No	0	6	6
168	R:R:F242	R:R:M243	6.22	No	No	0	5	5
169	R:R:F242	R:R:I246	8.79	No	No	0	5	5
170	R:R:H320	R:R:S244	6.97	Yes	No	0	7	6
171	R:R:F245	R:R:M249	7.46	No	No	0	8	6
172	R:R:F245	R:R:L317	7.31	No	No	0	8	7
173	R:R:F245	R:R:H320	4.53	No	Yes	0	8	7
174	R:R:F247	R:R:P248	4.33	No	Yes	0	6	9
175	R:R:F247	R:R:V251	3.93	No	No	0	6	6
176	R:R:F312	R:R:P248	5.78	No	Yes	0	9	9
177	R:R:F312	R:R:M249	4.98	No	No	0	9	6
178	R:R:I252	R:R:V309	4.61	No	No	0	8	8
179	R:R:L305	R:R:N256	9.61	No	No	0	8	9
180	R:R:N256	R:R:V309	4.43	No	No	0	9	8
181	R:R:I259	R:R:L305	4.28	No	No	0	9	8
182	R:R:K262	R:R:M266	4.32	No	No	0	5	6
183	R:R:L263	R:R:V302	4.47	No	Yes	0	8	7
184	R:R:R268	R:R:T264	3.88	No	No	0	4	5
185	R:R:R299	R:R:V267	3.92	No	No	0	5	6
186	R:R:A297	R:R:R294	4.15	No	No	0	6	4
187	R:R:H300	R:R:V367	4.15	No	No	0	8	7
188	R:R:V308	R:R:Y364	7.57	No	Yes	0	8	9
189	R:R:F312	R:R:W316	7.02	No	Yes	0	9	8
190	R:R:C315	R:R:S356	3.44	No	No	0	9	9
191	R:R:F353	R:R:W316	12.03	No	Yes	9	7	8
192	R:R:S356	R:R:W316	8.65	No	Yes	0	9	8
193	R:R:P318	R:R:T349	3.5	No	Yes	0	9	6
194	R:R:L352	R:R:P318	4.93	No	No	0	7	9
195	R:R:H320	R:R:Y319	6.53	Yes	Yes	0	7	6
196	R:R:R322	R:R:Y319	8.23	Yes	Yes	1	5	6
197	R:R:R323	R:R:Y319	8.23	Yes	Yes	1	6	6
198	R:R:N350	R:R:Y319	5.81	Yes	Yes	1	6	6
199	R:R:R322	R:R:R323	7.46	Yes	Yes	1	5	6
200	R:R:R322	R:R:Y342	11.32	Yes	Yes	1	5	4
201	R:R:F345	R:R:R322	4.28	No	Yes	1	4	5
202	R:R:R322	R:R:Y346	11.32	Yes	Yes	1	5	4
203	R:R:R322	R:R:T349	7.76	Yes	Yes	1	5	6
204	R:R:F326	R:R:Y342	6.19	No	Yes	0	4	4
205	R:R:C327	R:R:Y328	5.38	No	No	0	3	5
206	R:R:I329	R:R:Q333	5.49	No	No	0	3	1
207	R:R:I329	R:R:W334	11.74	No	Yes	0	3	4
208	R:R:D331	R:R:S330	4.42	No	No	0	1	2
209	R:R:W334	R:R:Y342	4.82	Yes	Yes	1	4	4
210	R:R:P336	R:R:T335	3.5	No	No	0	4	4
211	R:R:L338	R:R:T335	8.84	No	No	0	1	4
212	R:R:H343	R:R:Y339	18.51	No	Yes	1	4	2
213	R:R:F345	R:R:T349	7.78	No	Yes	1	4	6
214	R:R:N350	R:R:Y346	10.47	Yes	Yes	1	6	4
215	R:R:N350	R:R:T349	4.39	Yes	Yes	1	6	6
216	R:R:F353	R:R:Y354	5.16	No	No	0	7	7
217	R:R:N360	R:R:Y364	6.98	No	Yes	0	9	9
218	R:R:F371	R:R:N365	13.29	Yes	No	5	8	7
219	R:R:F375	R:R:L366	7.31	No	No	0	7	6
220	R:R:A369	R:R:R372	5.53	No	No	0	4	9
221	R:R:F371	R:R:F375	8.57	Yes	No	0	8	7
222	R:R:L110	R:R:W193	3.42	No	Yes	0	6	9
223	R:R:A154	R:R:S196	3.42	No	No	0	7	8
224	R:R:C315	R:R:V355	3.42	No	No	0	9	5
225	R:R:L338	R:R:W334	3.42	No	Yes	0	1	4
226	R:R:G221	R:R:N211	3.39	No	Yes	0	2	2
227	R:R:C151	R:R:T115	3.38	No	No	0	7	7
228	R:R:A109	R:R:T84	3.36	No	No	0	9	9
229	R:R:M120	R:R:P121	3.35	Yes	No	0	8	9
230	R:R:S356	R:R:S357	3.26	No	No	0	9	9
231	R:R:C171	R:R:K262	3.23	No	No	0	7	5
232	R:R:S253	R:R:V254	3.23	No	No	0	5	5
233	R:R:G220	R:R:H218	3.18	No	No	0	5	3
234	R:R:T100	R:R:V101	3.17	Yes	No	0	7	8
235	R:R:T264	R:R:V302	3.17	No	Yes	0	5	7
236	R:R:A109	R:R:L85	3.15	No	No	0	9	8
237	R:R:I252	R:R:V159	3.07	No	No	0	8	8
238	R:R:I374	R:R:T87	3.04	No	No	0	6	7
239	R:R:I228	R:R:T232	3.04	No	No	0	5	4
240	R:R:M249	R:R:V313	3.04	No	No	0	6	7
241	R:R:A214	R:R:E53	3.02	No	No	0	1	2
242	R:R:L73	R:R:V69	2.98	No	No	0	7	4
243	R:R:L73	R:R:V355	2.98	No	No	0	7	5
244	R:R:L255	R:R:V164	2.98	No	No	0	7	7
245	R:R:L298	R:R:V267	2.98	No	No	0	7	6
246	R:R:L317	R:R:V321	2.98	No	No	0	7	5
247	R:R:L113	R:R:T78	2.95	No	No	4	7	6
248	R:R:L117	R:R:T78	2.95	No	No	4	5	6
249	R:R:L113	R:R:T82	2.95	No	No	0	7	4
250	R:R:I60	R:R:K63	2.91	No	No	0	2	5
251	R:R:I374	R:R:K91	2.91	No	No	0	6	5
252	R:R:F205	R:R:P202	2.89	No	No	0	4	7
253	R:R:L263	R:R:M266	2.83	No	No	0	8	6
254	R:R:H300	R:R:V304	2.77	No	No	0	8	8
255	R:R:H131	R:R:T58	2.74	No	No	0	3	1
256	R:R:M266	R:R:Q269	2.72	No	No	0	6	7
257	R:R:F146	R:R:V201	2.62	Yes	No	0	6	5
258	R:R:R306	R:R:V302	2.62	No	Yes	0	5	7
259	R:R:F337	R:R:T335	2.59	No	No	0	2	4
260	R:R:F341	R:R:M325	2.49	No	No	0	4	4
261	R:R:Q296	R:R:R294	2.34	No	No	0	5	4
262	R:R:D340	R:R:Y339	2.3	No	Yes	0	1	2
263	R:R:L114	R:R:W193	2.28	No	Yes	0	8	9
264	R:R:A160	R:R:P248	1.87	No	Yes	0	8	9
265	R:R:G301	R:R:V304	1.84	No	No	0	8	8
266	R:R:A150	R:R:A200	1.79	No	No	0	6	7
267	R:R:G106	R:R:L85	1.71	No	No	0	6	8
268	R:R:G106	R:R:L88	1.71	No	No	0	6	7
269	R:R:A260	R:R:V302	1.7	No	Yes	0	6	7
270	R:R:A270	R:R:V295	1.7	No	No	0	5	3
271	R:R:S181	R:R:S183	1.63	No	No	0	8	4
272	R:R:A169	R:R:I170	1.62	No	No	0	8	9
273	R:R:S253	R:R:V309	1.62	No	No	0	5	8
274	R:R:A311	R:R:I359	1.62	No	No	0	7	6
275	R:R:V75	R:R:V76	1.6	No	No	0	5	6
276	R:R:V79	R:R:V83	1.6	No	No	0	5	6
277	R:R:V235	R:R:V239	1.6	No	No	0	4	5
278	R:R:V250	R:R:V254	1.6	No	No	0	3	5
279	R:R:C151	R:R:L118	1.59	No	No	0	7	5
280	R:R:T206	R:R:V236	1.59	Yes	No	0	5	6
281	R:R:A176	R:R:L168	1.58	No	No	0	6	4
282	R:R:A307	R:R:L363	1.58	No	No	0	7	8
283	R:R:I310	R:R:V314	1.54	No	No	0	5	6
284	R:R:I359	R:R:V355	1.54	No	No	0	6	5
285	R:R:I362	R:R:V367	1.54	No	No	0	6	7
286	R:R:H218	R:R:P50	1.53	No	No	0	3	4
287	R:R:H172	R:R:P173	1.53	No	No	0	6	8
288	R:R:M180	R:R:T100	1.51	No	Yes	0	7	7
289	R:R:F136	R:R:G140	1.51	Yes	No	0	7	6
290	R:R:F146	R:R:G143	1.51	Yes	No	0	6	5
291	R:R:A271	R:R:E272	1.51	No	No	0	4	5
292	L:L:K2	R:R:T230	1.5	No	No	0	0	4
293	R:R:L363	R:R:V308	1.49	No	No	0	8	8
294	R:R:L363	R:R:V367	1.49	No	No	0	8	7
295	R:R:N370	R:R:S368	1.49	No	No	0	7	8
296	R:R:N261	R:R:V265	1.48	No	No	0	4	4
297	R:R:L71	R:R:T67	1.47	No	No	0	5	6
298	R:R:D215	R:R:S213	1.47	No	No	0	2	1
299	R:R:I329	R:R:M325	1.46	No	No	0	3	4
300	R:R:Q238	R:R:V239	1.43	No	No	0	5	5
301	R:R:L263	R:R:L298	1.38	No	No	0	8	7
302	R:R:N211	R:R:Q217	1.32	Yes	No	0	2	1
303	R:R:F371	R:R:S368	1.32	Yes	No	0	8	8
304	R:R:F74	R:R:V75	1.31	Yes	No	0	7	5
305	R:R:H172	R:R:K175	1.31	No	No	0	6	4
306	R:R:D331	R:R:E332	1.3	No	No	0	1	1
307	R:R:V64	R:R:W129	1.23	No	Yes	0	6	5
308	R:R:Q238	R:R:Y328	1.13	No	No	0	5	5
309	R:R:H300	R:R:R372	1.13	No	No	0	8	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:L6	7.342	5	1	0
2	R:R:Y70	4.985	4	3	7
3	R:R:F74	4.3975	4	0	7
4	R:R:L94	12.7025	4	2	5
5	R:R:T100	4.975	4	0	7
6	R:R:H104	6.0075	4	6	8
7	R:R:D112	6.53	4	0	9
8	R:R:M120	5.198	5	3	8
9	R:R:E123	7.41333	6	1	6
10	R:R:F127	6.73167	6	1	4
11	R:R:W129	6.1975	4	0	5
12	R:R:W134	10.36	5	1	8
13	R:R:F136	4.89	5	1	7
14	R:R:Y144	5.988	5	1	6
15	R:R:F146	4.8125	4	0	6
16	R:R:N158	5.534	5	8	8
17	R:R:Y167	6.212	5	0	8
18	R:R:W193	4.836	5	8	9
19	R:R:T206	4.7725	4	0	5
20	R:R:M207	8.1525	4	0	6
21	R:R:N211	5.1	4	0	2
22	R:R:P226	6.5975	4	0	5
23	R:R:P248	3.93	4	0	9
24	R:R:V302	2.99	4	0	7
25	R:R:W316	7.238	5	9	8
26	R:R:Y319	7.612	5	1	6
27	R:R:H320	7.5875	4	0	7
28	R:R:R322	7.89	7	1	5
29	R:R:R323	9.6625	4	1	6
30	R:R:W334	8.09	5	1	4
31	R:R:Y339	10.822	5	1	2
32	R:R:Y342	8.0175	4	1	4
33	R:R:Y346	9.164	5	1	4
34	R:R:T349	5.8575	4	1	6
35	R:R:N350	6.698	5	1	6
36	R:R:Y364	6.07667	6	7	9
37	R:R:F371	7.23	5	5	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:P3	R:R:Y339	14.9333	5.56	No	Yes	1	0	2
2	L:L:P3	R:R:Y342	15.1615	9.74	No	Yes	1	0	4
3	R:R:R322	R:R:Y346	28.6037	11.32	Yes	Yes	1	5	4
4	R:R:R322	R:R:Y342	22.1508	11.32	Yes	Yes	1	5	4
5	R:R:M207	R:R:P226	29.4964	10.06	Yes	Yes	0	6	5
6	R:R:P226	R:R:T225	31.53	5.25	Yes	No	0	5	4
7	R:R:R212	R:R:T225	30.1329	11.64	No	No	0	1	4
8	R:R:Q210	R:R:R212	28.8599	8.18	No	No	0	1	1
9	R:R:Q210	R:R:T227	27.4549	5.67	No	No	0	1	3
10	R:R:G208	R:R:T227	26.0458	3.64	No	No	0	4	3
11	R:R:G208	R:R:R142	24.6327	6	No	No	0	4	7
12	R:R:D138	R:R:R142	23.2156	14.29	No	No	0	3	7
13	R:R:D138	R:R:E209	21.7946	5.2	No	No	0	3	5
14	R:R:E209	R:R:L222	18.9404	10.6	No	No	0	5	4
15	R:R:L222	R:R:N211	17.5073	8.24	No	Yes	0	4	2
16	R:R:G221	R:R:N211	10.2818	3.39	No	Yes	0	2	2
17	R:R:V56	R:R:Y339	11.0924	5.05	No	Yes	1	2	2
18	R:R:H131	R:R:V56	10.4319	19.37	No	No	0	3	2
19	R:R:E123	R:R:Y346	29.0141	5.61	Yes	Yes	1	6	4
20	R:R:E123	R:R:Y354	90.0184	11.22	Yes	No	0	6	7
21	R:R:M120	R:R:Y354	13.0579	7.18	Yes	No	0	8	7
22	R:R:F353	R:R:Y354	91.2153	5.16	No	No	0	7	7
23	R:R:F353	R:R:W316	90.8691	12.03	No	Yes	9	7	8
24	R:R:S356	R:R:W316	12.2153	8.65	No	Yes	0	9	8
25	R:R:T155	R:R:W316	100	4.85	No	Yes	0	9	8
26	R:R:D112	R:R:T155	89.7462	7.23	Yes	No	0	9	9
27	R:R:D112	R:R:L108	44.8441	5.43	Yes	No	0	9	9
28	R:R:L108	R:R:Y364	48.1606	7.03	No	Yes	0	9	9
29	R:R:L162	R:R:Y364	32.2665	4.69	No	Yes	7	9	9
30	R:R:L105	R:R:L162	31.2477	4.15	No	No	0	8	9
31	R:R:L105	R:R:N365	30.1429	5.49	No	No	0	8	7
32	R:R:F371	R:R:N365	22.0468	13.29	Yes	No	5	8	7
33	R:R:D112	R:R:N360	44.726	9.42	Yes	No	0	9	9
34	R:R:N360	R:R:Y364	44.4098	6.98	No	Yes	0	9	9
35	R:R:F371	R:R:T87	14.1768	7.78	Yes	No	0	8	7
36	R:R:I374	R:R:T87	13.0179	3.04	No	No	0	6	7
37	R:R:I374	R:R:K91	11.855	2.91	No	No	0	6	5
38	R:R:S111	R:R:T155	10.1937	4.8	No	No	0	8	9
39	R:R:E123	R:R:Y144	22.4611	4.49	Yes	Yes	1	6	6
40	R:R:M207	R:R:Y145	39.0857	10.78	Yes	No	0	6	4
41	R:R:F127	R:R:Y145	20.4776	5.16	Yes	No	1	4	4
42	R:R:M207	R:R:T206	16.9789	7.53	Yes	Yes	0	6	5
43	R:R:F205	R:R:T206	11.3827	3.89	No	Yes	0	4	5
44	R:R:N240	R:R:R323	17.6754	14.46	No	Yes	0	6	6
45	R:R:N240	R:R:Y153	11.0764	9.3	No	No	0	6	7
46	R:R:H320	R:R:Y319	12.7897	6.53	Yes	Yes	0	7	6
47	R:R:F245	R:R:H320	12.0532	4.53	No	Yes	0	8	7
48	R:R:F245	R:R:M249	11.5668	7.46	No	No	0	8	6
49	R:R:F312	R:R:M249	11.4267	4.98	No	No	0	9	6
50	R:R:V159	R:R:Y364	55.3621	5.05	No	Yes	0	8	9
51	R:R:I252	R:R:V159	54.3513	3.07	No	No	0	8	8
52	R:R:I252	R:R:V309	53.3305	4.61	No	No	0	8	8
53	R:R:N256	R:R:V309	49.2074	4.43	No	No	0	9	8
54	R:R:N256	R:R:S163	23.4939	5.96	No	No	0	9	9
55	R:R:L255	R:R:S163	22.403	6.01	No	No	0	7	9
56	R:R:L255	R:R:Y167	20.2254	10.55	No	Yes	0	7	8
57	R:R:C171	R:R:Y167	29.3603	6.72	No	Yes	0	7	8
58	R:R:L305	R:R:N256	24.6948	9.61	No	No	0	8	9
59	R:R:I259	R:R:L305	23.5999	4.28	No	No	0	9	8
60	R:R:I259	R:R:Y167	20.4055	3.63	No	Yes	0	9	8
61	R:R:C171	R:R:K262	27.0986	3.23	No	No	0	7	5
62	R:R:K262	R:R:M266	24.9109	4.32	No	No	0	5	6
63	R:R:L263	R:R:M266	20.3755	2.83	No	No	0	8	6
64	R:R:L263	R:R:V302	11.4047	4.47	No	Yes	0	8	7
65	R:R:V308	R:R:Y364	11.855	7.57	No	Yes	0	8	9
66	R:R:L363	R:R:V308	10.6781	1.49	No	No	0	8	8
67	R:R:E123	R:R:F127	27.1747	4.66	Yes	Yes	1	6	4
68	R:R:F312	R:R:W316	12.9278	7.02	No	Yes	0	9	8
69	R:R:Y144	R:R:Y145	19.4848	5.96	Yes	No	1	6	4
70	R:R:R323	R:R:Y319	15.6539	8.23	Yes	Yes	1	6	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:K1	R:R:Y339	22.69	0	No	Yes	0	2	0	1
L:L:K2	R:R:W334	6.96	0	No	Yes	0	4	0	1
L:L:P3	R:R:W334	13.51	1	No	Yes	0	4	0	1
L:L:P3	R:R:Y339	5.56	1	No	Yes	0	2	0	1
L:L:P3	R:R:Y342	9.74	1	No	Yes	0	4	0	1
L:L:Y4	R:R:L54	5.86	0	No	No	0	5	0	1
L:L:Y4	R:R:V223	15.14	0	No	No	0	4	0	1
L:L:I5	R:R:F127	10.05	1	No	Yes	0	4	0	1
L:L:I5	R:R:Y346	6.04	1	No	Yes	0	4	0	1
L:L:L6	R:R:M207	4.24	1	Yes	Yes	0	6	0	1
L:L:L6	R:R:I237	5.71	1	Yes	No	0	6	0	1
L:L:L6	R:R:R322	4.86	1	Yes	Yes	0	5	0	1
L:L:L6	R:R:R323	8.5	1	Yes	Yes	0	6	0	1
L:L:L6	R:R:F326	13.4	1	Yes	No	0	4	0	1
R:R:H132	R:R:L54	7.71	0	No	No	4	5	2	1
R:R:V56	R:R:Y339	5.05	1	No	Yes	2	2	2	1
R:R:H343	R:R:V56	16.61	1	No	No	4	2	2	2
R:R:E123	R:R:F127	4.66	1	Yes	Yes	6	4	2	1
R:R:E123	R:R:Y144	4.49	1	Yes	Yes	6	6	2	2
R:R:E123	R:R:Y346	5.61	1	Yes	Yes	6	4	2	1
R:R:E123	R:R:N350	9.2	1	Yes	Yes	6	6	2	2
R:R:F127	R:R:W134	4.01	1	Yes	Yes	4	8	1	2
R:R:F127	R:R:Y144	4.13	1	Yes	Yes	4	6	1	2
R:R:F127	R:R:Y145	5.16	1	Yes	No	4	4	1	2
R:R:F127	R:R:Y346	12.38	1	Yes	Yes	4	4	1	1
R:R:Y144	R:R:Y145	5.96	1	Yes	No	6	4	2	2
R:R:M207	R:R:Y145	10.78	0	Yes	No	6	4	1	2
R:R:M207	R:R:T206	7.53	0	Yes	Yes	6	5	1	2
R:R:M207	R:R:P226	10.06	0	Yes	Yes	6	5	1	2
R:R:F326	R:R:P226	5.78	0	No	Yes	4	5	1	2
R:R:C327	R:R:I237	8.18	0	No	No	3	6	2	1
R:R:N240	R:R:R323	14.46	0	No	Yes	6	6	2	1
R:R:R322	R:R:Y319	8.23	1	Yes	Yes	5	6	1	2
R:R:R323	R:R:Y319	8.23	1	Yes	Yes	6	6	1	2
R:R:N350	R:R:Y319	5.81	1	Yes	Yes	6	6	2	2
R:R:R322	R:R:R323	7.46	1	Yes	Yes	5	6	1	1
R:R:R322	R:R:Y342	11.32	1	Yes	Yes	5	4	1	1
R:R:F345	R:R:R322	4.28	1	No	Yes	4	5	2	1
R:R:R322	R:R:Y346	11.32	1	Yes	Yes	5	4	1	1
R:R:R322	R:R:T349	7.76	1	Yes	Yes	5	6	1	2
R:R:F326	R:R:Y342	6.19	0	No	Yes	4	4	1	1
R:R:I329	R:R:W334	11.74	0	No	Yes	3	4	2	1
R:R:W334	R:R:Y342	4.82	1	Yes	Yes	4	4	1	1
R:R:H343	R:R:Y339	18.51	1	No	Yes	4	2	2	1
R:R:F345	R:R:T349	7.78	1	No	Yes	4	6	2	2
R:R:N350	R:R:Y346	10.47	1	Yes	Yes	6	4	2	1
R:R:N350	R:R:T349	4.39	1	Yes	Yes	6	6	2	2
R:R:L338	R:R:W334	3.42	0	No	Yes	1	4	2	1
R:R:D340	R:R:Y339	2.3	0	No	Yes	1	2	2	1
L:L:K2	R:R:T230	1.5	0	No	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6OS9_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.44
Number of Linked Nodes	286
Number of Links	309
Number of Hubs	37
Number of Links mediated by Hubs	145
Number of Communities	9
Number of Nodes involved in Communities	52
Number of Links involved in Communities	68

Path Summary
Number Of Nodes in MetaPath	71
Number Of Links MetaPath	70
Number of Shortest Paths	78378
Length Of Smallest Path	3
Average Path Length	17.6324
Length of Longest Path	41
Minimum Path Strength	1.28
Average Path Strength	6.65142
Maximum Path Strength	20.6
Minimum Path Correlation	0.7
Average Path Correlation	0.930336
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	46.6179
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	35.739
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • adult locomotory behavior • behavior • multicellular organismal process • adult behavior • locomotory behavior • system process • learning • learning or memory • nervous system process • cognition • regulation of calcium ion transport • regulation of localization • intracellular calcium ion homeostasis • negative regulation of biological process • negative regulation of transport • calcium ion transport • localization • negative regulation of cation transmembrane transport • monoatomic cation homeostasis • monoatomic cation transport • intracellular monoatomic ion homeostasis • regulation of release of sequestered calcium ion into cytosol • regulation of monoatomic ion transport • establishment of localization • maintenance of location • transmembrane transport • release of sequestered calcium ion into cytosol • regulation of transmembrane transport • chemical homeostasis • negative regulation of calcium ion transmembrane transport • cellular localization • inorganic ion homeostasis • transport • homeostatic process • monoatomic ion transmembrane transport • negative regulation of monoatomic ion transport • positive regulation of biological process • calcium ion homeostasis • regulation of monoatomic ion transmembrane transport • negative regulation of sequestering of calcium ion • metal ion transport • negative regulation of transmembrane transport • maintenance of location in cell • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • positive regulation of sequestering of calcium ion • negative regulation of monoatomic ion transmembrane transport • negative regulation of release of sequestered calcium ion into cytosol • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • negative regulation of cellular process • monoatomic ion transport • intracellular chemical homeostasis • regulation of metal ion transport • regulation of sequestering of calcium ion • positive regulation of cellular process • calcium ion transmembrane import into cytosol • regulation of transport • sequestering of calcium ion • negative regulation of calcium ion transport • cellular homeostasis • regulation of monoatomic cation transmembrane transport • calcium ion transmembrane transport • regulation of postsynaptic membrane potential • regulation of system process • regulation of signal transduction • chemical synaptic transmission, postsynaptic • synaptic signaling • positive regulation of inhibitory postsynaptic potential • positive regulation of nervous system process • regulation of multicellular organismal process • regulation of biological quality • modulation of inhibitory postsynaptic potential • trans-synaptic signaling • regulation of signaling • cell surface receptor signaling pathway • cell-cell signaling • regulation of nervous system process • chemical synaptic transmission • regulation of response to stimulus • anterograde trans-synaptic signaling • inhibitory postsynaptic potential • positive regulation of multicellular organismal process • regulation of cell communication • regulation of membrane potential • negative regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • biosynthetic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • positive regulation of macromolecule metabolic process • macromolecule metabolic process • regulation of metabolic process • positive regulation of programmed cell death • positive regulation of apoptotic process • import into cell • nitrogen compound transport • organic anion transport • carboxylic acid transport • carboxylic acid transmembrane transport • aspartate transmembrane transport • import across plasma membrane • amino acid transmembrane transport • C4-dicarboxylate transport • D-amino acid transport • organic acid transport • amino acid transport • acidic amino acid transport • D-aspartate transmembrane transport • D-aspartate import across plasma membrane • dicarboxylic acid transport • amino acid import across plasma membrane • positive regulation of arachidonate secretion • regulation of lipid transport • regulation of arachidonate secretion • arachidonate secretion • monocarboxylic acid transport • positive regulation of secretion • fatty acid transport • icosanoid transport • regulation of icosanoid secretion • icosanoid secretion • long-chain fatty acid transport • positive regulation of icosanoid secretion • secretion • arachidonate transport • lipid localization • lipid transport • positive regulation of lipid localization • regulation of fatty acid transport • regulation of secretion • positive regulation of organic acid transport • positive regulation of lipid transport • positive regulation of transport • regulation of lipid localization • macromolecule localization • regulation of organic acid transport • positive regulation of fatty acid transport • regulation of membrane depolarization • membrane depolarization • polyol metabolic process • alcohol catabolic process • catabolic process • polyol catabolic process • organophosphate catabolic process • alcohol metabolic process • inositol phosphate metabolic process • organophosphate metabolic process • phosphate-containing compound metabolic process • inositol phosphate catabolic process • small molecule metabolic process • small molecule catabolic process • phosphorus metabolic process • detection of external stimulus • detection of stimulus involved in sensory perception of pain • response to external stimulus • sensory perception of temperature stimulus • sensory perception of pain • detection of temperature stimulus involved in sensory perception • response to temperature stimulus • detection of abiotic stimulus • detection of stimulus • sensory perception • detection of temperature stimulus • response to abiotic stimulus • detection of stimulus involved in sensory perception • detection of temperature stimulus involved in sensory perception of pain • L-glutamate import across plasma membrane • L-amino acid transport • L-glutamate import • L-alpha-amino acid transmembrane transport • L-glutamate transmembrane transport • multicellular organismal-level homeostasis • temperature homeostasis • regulation of systemic arterial blood pressure • circulatory system process • regulation of blood pressure • negative regulation of systemic arterial blood pressure • blood circulation • negative regulation of blood pressure • positive regulation of amine transport • gamma-aminobutyric acid transport • regulation of amino acid transport • gamma-aminobutyric acid secretion • regulation of gamma-aminobutyric acid secretion • positive regulation of gamma-aminobutyric acid secretion • acid secretion • amine transport • positive regulation of amino acid transport • regulation of amine transport • positive regulation of cation transmembrane transport • positive regulation of calcium ion transport • positive regulation of monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • positive regulation of calcium ion transmembrane transport • positive regulation of transmembrane transport • positive regulation of release of sequestered calcium ion into cytosol • regulation of respiratory gaseous exchange • respiratory gaseous exchange by respiratory system • response to lipid • response to chemical • regulation of glutamate secretion • positive regulation of secretion by cell • secretion by cell • regulation of secretion by cell • glutamate secretion • positive regulation of glutamate secretion • export from cell • regulation of inositol phosphate biosynthetic process • positive regulation of phosphate metabolic process • regulation of primary metabolic process • regulation of small molecule metabolic process • polyol biosynthetic process • regulation of carbohydrate metabolic process • carbohydrate metabolic process • positive regulation of phosphorus metabolic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • carbohydrate biosynthetic process • primary metabolic process • positive regulation of inositol phosphate biosynthetic process • organophosphate biosynthetic process • inositol phosphate biosynthetic process • alcohol biosynthetic process • regulation of phosphorus metabolic process • positive regulation of carbohydrate metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • symmetric synapse • cellular anatomical structure • neuron to neuron synapse • synapse • cell junction • somatodendritic compartment • cell body • perikaryon • neuronal cell body • axon • neuron projection • axon terminus • plasma membrane bounded cell projection • presynapse
Gene Ontology	Cellular Component	• symmetric synapse • cellular anatomical structure • neuron to neuron synapse • synapse • cell junction • somatodendritic compartment • cell body • perikaryon • neuronal cell body • axon • neuron projection • axon terminus • plasma membrane bounded cell projection • presynapse • cell projection • distal axon • terminal bouton • neuron projection terminus • cell surface • cell periphery • plasma membrane • membrane • membrane microdomain • membrane raft • membrane-bounded organelle • intracellular organelle • intracellular anatomical structure • Golgi apparatus • organelle • cytoplasm • intracellular membrane-bounded organelle • endomembrane system • dendrite • dendritic tree • dendritic shaft • neuron spine • dendritic spine • postsynapse • cytoplasmic side of plasma membrane • cytoplasmic side of membrane • side of membrane • endoplasmic reticulum • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • membrane protein complex • heterotrimeric G-protein complex • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • cilium • ciliary basal body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30989
Sequence	>6OS9_nogp_Chain_R P S S E L D V N T D I Y S K V L V T A V Y L A L F V V G T V G N T V T L F T L A R K K S L Q S L Q S T V H Y H L G S L A L S D L L T L L L A M P V E L Y N F I W V H H P W A F G D A G C R G Y Y F L R D A C T Y A T A L N V A S L S V E R Y L A I C H P F K A K T L M S R S R T K K F I S A I W L A S A L L A V P M L F T M G E Q N R S A D G Q H A G G L V C T P T I H T A T V K V V I Q V N T F M S F I F P M V V I S V L N T I I A N K L T V M V R Q A A E Q R V Q A L R H G V R V L R A V V I A F V V C W L P Y H V R R L M F C Y I S D E Q W T P F L Y D F Y H Y F Y M V T N A L F Y V S S T I N P I L Y N L V S A N F R H I F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JPB	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin-(8-13)	SBI-553; GDP; Mg	Gq; GRK2	3.07	2023-08-09	doi.org/10.1038/s41586-023-06395-9
	8JPB (No Gprot)	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin-(8-13)	SBI-553; GDP; Mg		3.07	2023-08-09	doi.org/10.1038/s41586-023-06395-9
	8JPC	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin-(8-13)	SBI-553; GDP; Mg	Gq; GRK2	3.07	2023-08-09	doi.org/10.1038/s41586-023-06395-9
	8JPC (No Gprot)	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin-(8-13)	SBI-553; GDP; Mg		3.07	2023-08-09	doi.org/10.1038/s41586-023-06395-9
	8FN0	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	SBI-553	chim(NtGi1-Go)/β1/γ2	2.89	2023-03-29	doi.org/10.1021/acs.biochem.3c00029
	8FN0 (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	SBI-553		2.89	2023-03-29	doi.org/10.1021/acs.biochem.3c00029
	8JPF	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin	SBI-553	-	3.02	2023-08-09	doi.org/10.1038/s41586-023-06395-9
	8ZYT	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin peptide 8-13	SBI-553	Arrestin2	2.65	2025-04-09	doi.org/10.1038/s41422-025-01095-7
	8ZYY	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin peptide 8-13	SBI-553	Arrestin2	2.83	2025-04-09	doi.org/10.1038/s41422-025-01095-7
	8ZYU	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin peptide 8-13	SBI-553	Arrestin2	2.65	2025-04-16	doi.org/10.1038/s41422-025-01095-7
	7UL2	A	Peptide	Neurotensin	NTS₁	Homo sapiens	SR48692	Na	-	2.4	2022-06-29	doi.org/10.1038/s41594-022-00859-8
	8FMZ	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	2.59	2023-03-29	doi.org/10.1021/acs.biochem.3c00029
	8FMZ (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	-		2.59	2023-03-29	doi.org/10.1021/acs.biochem.3c00029
	8FN1	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	-	chim(NtGi1-Go)/β1/γ2	2.88	2023-03-29	doi.org/10.1021/acs.biochem.3c00029
	8FN1 (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/Neuromedin-N	-		2.88	2023-03-29	doi.org/10.1021/acs.biochem.3c00029
	4GRV	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin-(8-13)	-	-	2.8	2012-10-17	doi.org/10.1038/nature11558
	4XEE	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	2.9	2015-07-29	doi.org/10.1038/ncomms8895
	4XES	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	2.6	2015-07-29	doi.org/10.1038/ncomms8895
	6PWC	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin	-	Arrestin2	4.9	2019-12-04	doi.org/10.1038/s41422-019-0256-2
	6OS9	A	Peptide	Neurotensin	NTS₁	Homo sapiens	JMV449	-	Gi1/β1/γ2	3	2019-07-10	doi.org/10.1038/s41586-019-1337-6
	6OS9 (No Gprot)	A	Peptide	Neurotensin	NTS₁	Homo sapiens	JMV449	-		3	2019-07-10	doi.org/10.1038/s41586-019-1337-6
	6OSA	A	Peptide	Neurotensin	NTS₁	Homo sapiens	JMV449	-	Gi1/β1/γ2	3	2019-07-10	doi.org/10.1038/s41586-019-1337-6
	6OSA (No Gprot)	A	Peptide	Neurotensin	NTS₁	Homo sapiens	JMV449	-		3	2019-07-10	doi.org/10.1038/s41586-019-1337-6
	6UP7	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin	-	Arrestin2	4.2	2020-02-26	doi.org/10.1038/s41586-020-1953-1
	7L0P	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	Gi1/β1/γ1	4.1	2021-01-06	doi.org/10.1038/s41594-020-00554-6
	7L0P (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-		4.1	2021-01-06	doi.org/10.1038/s41594-020-00554-6
	7L0Q	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	Gi1/β1/γ1	4.3	2021-01-06	doi.org/10.1038/s41594-020-00554-6
	7L0Q (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-		4.3	2021-01-06	doi.org/10.1038/s41594-020-00554-6
	7L0R	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	Gi1/β1/γ1	4.2	2021-01-06	doi.org/10.1038/s41594-020-00554-6
	7L0R (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-		4.2	2021-01-06	doi.org/10.1038/s41594-020-00554-6
	7L0S	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	Gi1/β1/γ1	4.5	2021-01-06	doi.org/10.1038/s41594-020-00554-6
	7L0S (No Gprot)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-		4.5	2021-01-06	doi.org/10.1038/s41594-020-00554-6
	5T04	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	3.3	2016-12-21	doi.org/10.1038/srep38564
	3ZEV	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	3	2014-01-29	doi.org/10.1073/pnas.1317903111
	4BUO	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	2.75	2014-01-29	doi.org/10.1073/pnas.1317903111
	4BV0	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	3.1	2014-01-29	doi.org/10.1073/pnas.1317903111
	4BWB	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	3.57	2014-01-29	doi.org/10.1073/pnas.1317903111
	6YVR	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	NTS8-13	-	-	2.46	2021-02-10	doi.org/10.1126/sciadv.abe5504
	6Z4Q	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	SR142948A	-	-	2.92	2021-02-10	doi.org/10.1126/sciadv.abe5504
	6Z4S	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	SR48692	-	-	2.71	2021-02-10	doi.org/10.1126/sciadv.abe5504
	6Z4V	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	NTS8-13	-	-	2.6	2021-02-10	doi.org/10.1126/sciadv.abe5504
	6Z66	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	-	-	-	3.19	2021-02-10	doi.org/10.1126/sciadv.abe5504
	6Z8N	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	SRI-9829	-	-	2.8	2021-02-10	doi.org/10.1126/sciadv.abe5504
	6ZA8	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	RTI-3a	-	-	2.72	2021-02-10	doi.org/10.1126/sciadv.abe5504
	6ZIN	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	SR48692	-	-	2.64	2021-02-10	doi.org/10.1126/sciadv.abe5504
	9M0D	A	Peptide	Neurotensin	NTS₁	Homo sapiens	-	-	Arrestin2	3.41	2025-04-09	doi.org/10.1038/s41422-025-01095-7

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