CodeSTU
NameStaurosporine
SynonymsStaurosporine
Identifiern/a
FormulaC28 H26 N4 O3
Molecular Weight466.531
SMILESC[C@@]12[C@@H]([C@@H](C[C@@H](O1)n3c4ccccc4c5c3c6n2c7ccccc7c6c8c5C(=O)NC8)NC)OC
PubChem44259
Formal Charge0
Total Atoms61
Total Chiral Atoms4
Total Bonds68
Total Aromatic Bonds24
Networks2
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This ligand is also present in the following 2 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8JPB A Peptide Neurotensin NTS1 Homo Sapiens Neurotensin 8-13 PubChem 118610427; GDP; Mg Gq; GRK2 3.07 2023-08-09 10.1038/s41586-023-06395-9

A 2D representation of the interactions of STU in 8JPB
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
K:K:I197 K:K:V205 4.61 17 No No 9 9 1 1
K:K:?701 K:K:I197 20.28 17 Yes No 0 9 0 1
K:K:?701 K:K:G198 7.4 17 Yes No 0 9 0 1
K:K:?701 K:K:V205 22.09 17 Yes No 0 9 0 1
K:K:?701 K:K:A218 5.84 17 Yes No 0 9 0 1
K:K:K220 K:K:L222 4.23 0 No No 9 9 1 2
K:K:E239 K:K:K220 6.75 7 Yes No 9 9 2 1
K:K:?701 K:K:K220 10.45 17 Yes No 0 9 0 1
K:K:L271 K:K:V255 4.47 0 No No 9 9 1 2
K:K:L324 K:K:M274 7.07 17 No No 9 9 1 1
K:K:M274 K:K:R332 11.17 17 No No 9 9 1 2
K:K:?701 K:K:M274 5.24 17 Yes No 0 9 0 1
K:K:?701 K:K:D278 5.87 17 Yes No 0 9 0 1
K:K:D335 K:K:N322 6.73 0 No Yes 9 9 1 2
K:K:L324 K:K:S334 6.01 17 No No 9 9 1 2
K:K:?701 K:K:L324 14.54 17 Yes No 0 9 0 1
K:K:?701 K:K:D335 6.71 17 Yes No 0 9 0 1
K:K:?701 K:K:L271 3.42 17 Yes No 0 9 0 1
K:K:G276 K:K:G277 2.11 18 No No 9 9 2 1
K:K:?701 K:K:G277 2.11 17 Yes No 0 9 0 1
K:K:?701 K:K:A479 1.95 17 Yes No 0 9 0 1
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub0.00
Average Interaction Strength8.83
Average Nodes In Shell20.00
Average Hubs In Shell3.00
Average Links In Shell21.00
Average Links Mediated by Hubs In Shell14.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8JPC A Peptide Neurotensin NTS1 Homo Sapiens Neurotensin 8-13 PubChem 118610427; GDP; Mg Gq; GRK2 3.07 2023-08-09 10.1038/s41586-023-06395-9

A 2D representation of the interactions of STU in 8JPC
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
K:K:I197 K:K:Y13 3.63 3 No Yes 9 9 1 2
K:K:I197 K:K:V205 4.61 3 No No 9 9 1 1
K:K:?701 K:K:I197 19.4 3 Yes No 0 9 0 1
K:K:G198 K:K:I485 3.53 0 No No 9 9 1 2
K:K:?701 K:K:G198 7.4 3 Yes No 0 9 0 1
K:K:K220 K:K:V205 4.55 3 Yes No 9 9 1 1
K:K:?701 K:K:V205 24.85 3 Yes No 0 9 0 1
K:K:?701 K:K:A218 5.84 3 Yes No 0 9 0 1
K:K:K220 K:K:L222 5.64 3 Yes No 9 9 1 2
K:K:E239 K:K:K220 5.4 3 Yes Yes 9 9 2 1
K:K:?701 K:K:K220 8.71 3 Yes Yes 0 9 0 1
K:K:L271 K:K:V255 4.47 0 No No 9 9 1 2
K:K:L324 K:K:M274 7.07 0 No No 9 9 1 2
K:K:D317 K:K:N322 6.73 3 Yes Yes 9 9 2 2
K:K:D317 K:K:D335 3.99 3 Yes No 9 9 2 1
K:K:D335 K:K:N322 5.39 3 No Yes 9 9 1 2
K:K:L324 K:K:S334 7.51 0 No No 9 9 1 2
K:K:?701 K:K:L324 10.26 3 Yes No 0 9 0 1
K:K:?701 K:K:D335 6.71 3 Yes No 0 9 0 1
K:K:?701 K:K:L271 3.42 3 Yes No 0 9 0 1
K:K:?701 K:K:G277 3.17 3 Yes No 0 9 0 1
K:K:?701 K:K:A479 1.95 3 Yes No 0 9 0 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub1.00
Average Interaction Strength9.17
Average Nodes In Shell20.00
Average Hubs In Shell6.00
Average Links In Shell22.00
Average Links Mediated by Hubs In Shell17.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub0.50
Average Interaction Strength9.00
Average Nodes In Shell20.00
Average Hubs In Shell4.50
Average Links In Shell21.50
Average Links Mediated by Hubs In Shell15.50

missing image


Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)