Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.HN.11 4.9075402
2G.S1.02 6.6025475
3G.S1.03 4.152519
4G.s1h1.06 3.0275409
5G.H1.01 3.688509
6G.H1.04 4.645407
7G.H1.08 6.7875478
8G.S2.08 7.5875475
9G.S3.01 5.28474
10G.S3.03 8.302577
11G.S3.04 8.935416
12G.S3.05 4.79477
13G.S3.06 7.504515
14G.s3h2.03 5.878519
15G.H2.04 4.8775409
16G.H2.06 8.0425139
17G.H2.07 5.74833619
18G.h2s4.01 8.6625419
19G.s4h3.04 6.876676118
20G.s4h3.05 7.75254119
21G.H3.09 6.9256109
22G.H3.17 8.50833615
23G.H3.18 6.93419
24G.S5.05 4.6485169
25G.HG.04 5.6265119
26G.hgh4.02 5.3607
27G.hgh4.05 10.5075407
28G.H4.03 7.7875404
29G.h4s6.02 5.4408
30G.s6h5.01 6.3654169
31G.H5.08 5.6825478
32b.1x11 4.18408
33b.lhb1x6 4.92403
34b.lhb1x9 4.8425403
35b.b1x6 8.5325439
36b.l1x3 10.482539
37b.b2x1 9.524518
38b.b2x5 6.746537
39b.b3x3 5.55458
40b.l3x2 7.53439
41b.b4x3 7.345457
42b.b4x4 8.05538
43b.b4x5 5.42457
44b.b4x6 10.2533639
45b.b5x2 7.035407
46b.b5x3 7.54667639
47b.b5x5 6.295455
48b.b5x7 6.1175457
49b.l5x1 5.6075458
50b.l5x5 8.4475819
51b.b6x5 4.96167656
52b.b7x1 6.78404
53b.b7x2 4.215458
54b.l7x2 5.815419
55b.b8x3 4.565126
56b.b8x4 4.96167656
57b.l8x8 5.715454
58b.l9x3 8.086519
59b.l9x6 7.39429718
60b.b10x5 5.308577129
61b.l11x2 8.48419
62b.b12x5 3.9525466
63b.b12x6 9.45667618
64b.b12x7 6.5375469
65b.l12x1 4.5154126
66b.b13x7 8.676567
67b.l13x3 9.97509
68b.l13x6 6.2475419
69b.b14x3 5.425405
70b.b15x1 9.99469
71b.b16x4 9.832566
72b.b16x6 10.564568
73b.b17x5 8.59447
74b.b17x7 8.762548
75b.l17x3 9.14143749
76b.l17x6 8.8525139
77b.b18x5 6.0825405
78b.l18x1 6.895156
79b.b19x2 9.042546
80b.l19x2 8.585449
81b.b20x2 7.0775446
82b.b20x4 10.594548
83b.b20x6 9.445446
84b.b21x1 9.2225447
85b.b21x5 7.3675404
86b.b21x7 5.90833605
87b.l21x7 4.9975405
88b.b23x1 5.4375405
89b.b23x6 7.655607
90b.l25x3 8.832599
91b.l25x6 12.555418
92b.l27x1 11.5957719
93b.l27x2 9.1125499
94b.b28x2 5.09494
95b.b28x3 5.655437
96b.b28x4 9.1175496
97b.b28x6 9.658599
98g.h2x11 9.67254156
99g.ctx6 4.51667606
100g.ctx15 7.95439
101g.ctx16 6.63167638
102Lig 10.95681920
1031x39 4.678508
104I1 11.34406
1052x42 6.61507
1062x46 6.5175489
1072x50 8.28489
1082x53 5.726508
1092x63 5.9375425
110E1 5.6025424
111E1x50 10.392529
112E1x52 7.096508
1133x34 4.7145195
1143x36 5.7525428
1153x38 6.99254197
1163x46 4.87489
1173x49 7.9254148
1183x50 6.784589
1193x53 5.50754147
120I2x57 10.3054146
1214x54 4.9725403
1224x65 8.35425
123E2 14.531423
124E2x52 7.88425
1255x39 5425
1265x43 6.78425
1275x50 3.655409
1285x58 8.95689
1295x64 4.245405
130I3 6.1175405
1316x34 5.075407
1326x40 7.355488
1336x44 7.01429
1346x48 7.412529
1356x51 7.37426
1366x59 5.8425405
137E3 7.06402
1387x42 5.045407
1397x49 8.505489
1407x53 6.31689
1418x48 7.404505
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1G.HN.40 b.b5x2 25.03928.94NoYes077
2G.HN.40 b.b5x3 25.00184.59NoYes079
3b.b4x4 b.b5x3 24.75815.82YesYes389
4b.b4x4 b.l1x3 49.128913.26YesYes389
5b.l1x3 b.l3x2 97.42567.56YesYes399
6b.l1x4 b.l3x2 97.39145.43NoYes069
7I1 b.l1x4 96.91448.46YesNo066
8b.b5x2 b.l4x3 25.46788.77YesNo076
9b.b4x7 b.l4x3 25.506611.56NoNo086
10b.b4x7 b.l2x5 25.546115.48NoNo085
11b.l2x3 b.l2x5 1004.76NoNo085
12b.b3x1 b.l2x3 99.96546.79NoNo058
13b.b3x1 b.b6x5 99.93064.69NoYes056
14b.b6x5 b.b7x2 98.22643.79YesYes568
15b.b7x2 b.b8x4 98.29983.79YesYes586
16b.b8x2 b.b8x4 98.38995.09NoYes086
17b.b8x2 b.b9x3 98.35155.75NoNo086
18b.b9x3 b.l7x5 98.43415.47NoNo066
19b.l7x3 b.l7x5 98.35644.2NoNo096
20b.l5x3 b.l7x3 98.31748.83NoNo089
21b.l5x3 b.l5x5 98.27833.71NoYes089
228x48 I1 96.199916.31YesYes056
237x54 8x48 90.72275.73NoYes075
242x43 7x54 89.99845.24NoNo087
252x43 7x53 80.83364.13NoYes889
265x58 7x53 75.7043.97YesYes899
275x58 6x37 29.32388.46YesNo098
285x62 6x37 29.25584.61NoNo058
295x62 6x34 28.98087.87NoYes057
306x34 I3 27.87964.16YesYes075
31G.H5.17 I3 26.776314.1NoYes055
32G.H5.17 G.H5.26 26.50023.72NoNo055
33G.H5.20 G.H5.26 25.67113.65NoNo095
343x54 G.H5.20 25.39452.98NoNo089
353x54 G.H5.16 22.06584.61NoNo086
36G.H5.16 I2x50 21.78766.77NoNo068
37G.H5.15 I2x50 21.50933.39NoNo078
38G.H5.11 G.H5.15 20.95233.07NoNo087
39G.H5.11 G.S3.03 17.27513.93NoYes787
40G.h2s4.01 b.l5x5 28.015512.03YesYes199
41b.l5x5 b.l7x2 44.34447.97YesYes199
42G.s3h2.03 b.l7x2 16.69695.32YesYes199
43G.H2.07 G.h2s4.01 27.84194.01YesYes199
44G.H2.07 b.l7x2 27.58375.69YesYes199
45G.H2.07 b.l9x6 34.41583.86YesYes198
46G.s3h2.03 b.l9x6 15.62537.89YesYes198
47G.H2.04 G.H2.07 27.20257YesYes099
48G.H2.04 G.H3.08 24.01564.86YesNo099
49b.b2x1 b.l3x1 28.291918.04YesNo189
50b.l3x1 b.l5x5 28.55947.67NoYes199
51b.b2x1 b.l27x1 27.526210.61YesYes189
52G.H3.08 G.S4.04 23.79986.09NoNo099
53G.H3.09 G.S4.04 23.581216.08YesNo099
54G.H4.15 G.S4.06 14.23236.55NoNo087
55G.H3.09 G.H4.15 14.45166.43YesNo1098
56G.S4.06 G.S5.06 13.34174.47NoNo078
57G.S5.06 G.s4h3.01 10.42619.69NoNo087
58G.HG.04 G.s4h3.01 10.20198.53YesNo097
59b.l25x6 b.l27x1 16.030620.99YesYes189
60b.l23x1 b.l25x6 18.365919.06NoYes168
61b.l21x7 b.l23x1 18.27496.22YesNo056
62b.b23x6 b.l21x7 17.7214.03YesYes075
63b.b23x6 b.b24x6 16.20056.75YesNo078
64b.b21x7 b.b24x6 15.77823.86YesNo058
65b.b20x5 b.b21x7 10.22237.03NoYes075
66b.b20x5 b.b21x4 10.09945.54NoNo075
67b.l25x5 b.l27x1 12.20966.78NoYes079
68b.b24x1 b.l25x5 12.06054.83NoNo047
698x54 b.b24x1 11.91153.72NoNo064
708x51 8x54 11.76325.75NoNo086
718x51 b.l25x4 11.6155.53NoNo085
72b.l25x4 b.l27x2 11.467813.31NoYes059
73b.l25x3 b.l27x2 10.550310.08YesYes999
74b.l2x5 b.l4x2 74.52730.87NoNo054
75b.l4x2 g.ctx16 73.07657.22NoYes348
76b.b1x6 b.b4x6 49.542717.08YesYes399
77b.b1x6 b.b28x5 74.06585.71YesNo395
78b.b3x4 b.b4x6 24.94386.18NoYes399
79b.l11x1 b.l9x6 44.793710.14NoYes198
80b.b11x6 b.l11x1 44.52453.71NoNo199
81b.b11x6 b.l9x3 42.188815.34NoYes199
82b.b12x6 b.l9x3 41.24454.23YesYes189
83b.b12x6 b.b9x4 39.618418.22YesNo089
84b.b8x3 b.b9x4 39.28994.28YesNo069
85b.b10x5 b.b8x3 18.18045.02YesYes1296
86b.b10x5 b.b11x2 15.84348.79YesNo1297
87b.b10x3 b.b11x2 31.00154.91NoNo087
88b.b10x3 b.b6x2 29.6595.07NoNo088
89b.b10x2 b.b6x2 28.98753.38NoNo068
90b.b8x3 b.l12x1 16.167.36YesYes1266
91b.b11x2 b.l12x1 15.82914.42NoYes1276
92b.b10x2 b.b14x3 26.97256.35NoYes065
93b.b14x3 b.b15x1 15.51694.87YesYes059
943x47 5x58 48.649515.26NoYes099
953x47 5x54 48.38547.74NoNo098
965x54 6x44 48.12117.54NoYes089
976x44 6x48 45.941510.02YesYes299
983x36 6x48 43.8765.82YesYes289
993x36 Lig 27.41826.22YesYes280
100E2 Lig 10.76316.54YesYes230
1012x53 3x36 14.1944.98YesYes088
102b.b28x5 g.ctx16 73.84266.28NoYes358
103b.b4x4 b.b4x6 25.470315.27YesYes389
104b.b3x4 b.l1x3 49.29239.76NoYes399
105b.b28x3 b.b3x4 24.45646.01YesNo379
106b.b1x6 b.b28x3 24.53836.92YesYes397
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
6x58Lig16.062NoYes4010
6x61Lig14.162NoYes2010
7x30Lig13.452NoYes5010
E2Lig6.542YesYes3010
E2x51Lig27.882NoYes3010
4x65Lig4.142YesYes5010
E2x52Lig6.172YesYes5010
E1Lig9.282YesYes4010
7x34Lig4.022NoYes4010
6x51Lig6.492YesYes6010
3x32Lig7.312NoYes6010
3x33Lig8.412NoYes4010
3x36Lig6.222YesYes8010
7x38Lig3.892NoYes6010
4x61Lig6.522NoYes5010
5x43Lig9.222YesYes5010
1x397x384.990YesNo8621
2x533x327.310YesNo8621
2x533x364.980YesYes8821
2x63E14.962YesYes5421
2x63E23.822YesYes5321
2x64E140NoYes5421
2x67E25.532NoYes4321
7x35E14.170NoYes3421
E1x49E26.630NoYes5321
3x294x6516.870NoYes6521
3x334x576.192NoNo4712
3x335x436.262NoYes4511
3x366x485.822YesYes8912
3x366x515.992YesYes8611
3x374x575.280NoNo7722
3x375x436.410NoYes7521
4x614x653.952NoYes5511
4x64E2x524.832NoYes4521
4x64E219.872NoYes4321
4x65E2x528.442YesYes5511
E2E249.342YesYes3311
E2E2x5112.022YesNo3311
E2E2x5212.082YesYes3511
5x36E218.12NoYes4321
5x39E27.872YesYes5321
5x29E25.892NoYes4321
5x395x435.232YesYes5521
6x516x526.532YesNo6812
6x516x5510.472YesNo6512
6x547x349.690NoNo4421
6x556x585.260NoNo5421
6x587x3072NoNo4511
6x61E35.482NoYes2212
7x307x344.872NoNo5411
5x32E23.370NoYes3321
3x22E23.020NoYes3321
7x317x3232NoNo4112
7x31Lig2.642NoYes4010

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
100.00Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
88.24Consensuschemerin_onOrthosteric Ligandcml1_on
80.95Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
77.27Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
69.57Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
69.57Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
68.18Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
63.64Consensusangiotensin_onOrthosteric Ligandat1_on
63.64Consensusat1_onOrthosteric Ligand7F6G-AT1-(Sar1)-Angiotensin II-Gq/β1/γ2
63.16Single9L3WChemerin9L3W-CML1-Chemerin-Gi1/β1/γ2
61.90Single9UYJChemerin-99UYJ-CML2-Chemerin-9-Arrestin2
60.87Single7F6G(Sar1)-Angiotensin II7F6G-AT1-(Sar1)-Angiotensin II-Gq/β1/γ2
60.87Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
60.87Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-(Sar1)-Angiotensin II-Gq/β1/γ2
60.87Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-(Sar1)-Angiotensin II-Gq/β1/γ2
60.87Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
60.00Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
59.09Single6DO1(Sar1,Ile8)-Angiotensin II6DO1-AT1-(Sar1,Ile8)-Angiotensin II
59.09Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
56.52Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
55.00Single6OS0Angiotensin II6OS0-AT1-Angiotensin II
54.55Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
54.55Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
54.17Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
54.17Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
53.85Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
53.85Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
53.85Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
52.63Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
52.38Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
51.85Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
51.85Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
51.85Consensusbradykinin_onOrthosteric Ligandbk2_on
51.85Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
51.85Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
50.00Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
50.00Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
50.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single9KUWCMPD6449KUW-Apelin; Apelin-CMPD644-Arrestin2 ; Arrestin2
50.00Single9UMJEP549UMJ-C3aB-EP54-Go/β1/γ2
50.00Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
50.00Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
48.15Single7EIBKallidin-des-Arg107EIB-BK1-Kallidin-des-Arg10-chim(NtGi1-Gs-CtGq)/β1/γ2
48.15Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
48.00Single6JODAngiotensin II6JOD-AT2-Angiotensin II
48.00Consensusapelin_onOrthosteric Ligand8XZH-Apelin; Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin; Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
48.00Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin; Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin; Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
48.00Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
47.83Single4IARErgotamine4IAR-5-HT1B-Ergotamine
47.83Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
47.83Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
47.83Single8WDTphotoNECA8WDT-A2A-photoNECA
47.83Single9UMRC5a-pep9UMR-C5a1-C5a-pep-Go/β1/γ2
47.83Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
47.62Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
47.62Single6MXTSalmeterol6MXT-β2-Salmeterol
47.62Single6OS2TRV0266OS2-AT1-TRV026
47.62Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
47.62Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
47.62Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
47.62Single8JJPChemerin-98JJP-CML2-Chemerin-9-Gi1/β1/γ2
47.62Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
47.37Single7VGZRamelteon7VGZ-MT1-Ramelteon-Gi1/β1/γ2
46.15Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
46.15Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
46.15Single8XQEApelin-138XQE-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
46.15Consensusgi_apelinOrthosteric Ligand8XZH-Apelin; Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin; Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
46.15Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-14-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
45.83Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
45.83Single7W0NElabela7W0N-Apelin; Apelin-Elabela-Gi1/β1/γ2
45.83Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
45.83Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
45.83Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
45.83Single9ME1CXCL129ME1-CXCR4-CXCL12
45.83Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
45.83Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
45.45Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
45.45Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
45.45Single7Y65C5a (C-terminal peptide)7Y65-C5a1-C5a (C-terminal peptide)-Gi1/β1/γ2
45.45Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
45.45Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
45.00Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
45.00Single6D26Fevipiprant6D26-DP2-Fevipiprant
45.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
45.00Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
45.00Single7VFXfMIFL7VFX-FPR1-ALX-fMIFL-Gi1/β1/γ2
45.00Single9KUVCMPD6449KUV-Apelin-CMPD644-Arrestin2
45.00Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
45.00Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
45.00Consensusdp_offOrthosteric Liganddp2_off
45.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMIFL-Gi1/β1/γ2
45.00Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMIFL-Gi1/β1/γ2
44.83Single5GLHEndothelin-15GLH-ETB-Endothelin-1
44.44Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
44.44Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
44.44Single8GNGIstradefylline8GNG-A2A-Istradefylline
44.00Single9MEUCXCL129MEU-CXCR4-CXCL12
44.00Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
44.00Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
44.00Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
43.48Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
43.48Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
43.48Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
43.48Single9KX6C5a-des-Arg9KX6-C5a1-C5a-des-Arg-Go/β1/γ2
43.48Single9KZ8EP679KZ8-C3aB-EP67-Go/β1/γ2
42.86Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
42.86Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
42.86Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
42.86Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
42.86Single8HPTC5a (C-terminal peptide)8HPT-C5a1-C5a (C-terminal peptide)-Go/β1/γ2
42.86Single8UGWCGS216808UGW-A2A-CGS21680
42.86Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
42.86Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
42.86Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
42.31Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
42.31Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
42.31Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
42.31Single8X8LCortistatin-148X8L-SST5-Cortistatin-14-chim(NtGi1-Gs-CtGi1)/β1/γ2
42.31Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
42.11Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
42.11Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
42.11Single7UL3Famotidine7UL3-H2-Famotidine
42.11Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
42.11Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
42.11Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
41.67Single7NA7Ghrelin7NA7-Ghrelin-Ghrelin-Gi1/β1/γ2
41.67Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
41.67Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs)/β1/γ2
41.67Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-14-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
41.38Single6IGLIRL16206IGL-ETB-IRL1620
41.18Single6ME5Agomelatine6ME5-MT1-Agomelatine
41.18Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
40.91Single4RWADIPP-NH24RWA-δ-DIPP-NH2
40.91Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
40.91Single6DRYMethylergometrine6DRY-5-HT2B-Methylergometrine
40.91Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
40.91Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
40.91Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
40.91Single8JJLOlodaterol8JJL-β2-Olodaterol
40.91Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
40.91Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoprenaline-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
40.91Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoprenaline-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
40.91Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
40.91Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
40.74Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
40.74Single7Y64C5a7Y64-C5a1-C5a-Gi1/β1/γ2
40.74Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGi1)/β1/γ2
40.00Single3QAKUK-4320973QAK-A2A-UK-432097
40.00Single6D27CAY104716D27-DP2-CAY10471
40.00Single6IGKEndothelin-36IGK-ETB-Endothelin-3
40.00Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
40.00Single7XNACYN1548067XNA-SST2-CYN154806
40.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
40.00Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
40.00Single8JZZC5a-des-Arg8JZZ-C5a1-C5a-des-Arg-Go/β1/γ2
40.00Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
40.00Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
40.00Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
40.00Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
40.00Single8WSSMCH8WSS-MCH1-MCH-Gi1/β1/γ1
40.00Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
40.00Single8Z7JJN241-98Z7J-Apelin-JN241-9-Gi1/β1/γ2
40.00Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
40.00Single9CHXCarazolol9CHX-β2-Carazolol
40.00Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
40.00Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
40.00Single9KFJPubChem 1383196749KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
40.00Single9KUXCMPD6449KUX-Apelin; Apelin-CMPD644-Arrestin2
40.00Single9VMYTMU41429VMY-5-HT1A-TMU4142-Go/β1/γ2
40.00Consensusa3_onOrthosteric Liganda3a_on
40.00Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
40.00Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
40.00Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
40.00Consensusbombesin_onOrthosteric Ligandbb2_on
40.00Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
40.00Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
40.00Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-Ibutamoren-Gi1/β1/γ2
40.00Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-Ibutamoren-Gi1/β1/γ2
40.00Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
40.00Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-Gi1/β1/γ2 7NA8-Ghrelin-Ibutamoren-Gi1/β1/γ2
40.00Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
40.00Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
40.00Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
40.00Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
40.00Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
40.00Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
40.00Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
40.00Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
40.00Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
39.29Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
39.29Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
39.29Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
39.29Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
39.29Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-C5a-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a-Gi1/β1/γ2 7Y64-C5a1-C5a-Gi1/β1/γ2
39.13Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
39.13Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
39.13Single6IBLArformoterol6IBL-β1-Arformoterol
39.13Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
39.13Single7EZCUK-4320977EZC-A2A-UK-432097
39.13Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
39.13Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
39.13Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
39.13Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
39.13Single8E0GBU728E0G-μ-BU72
39.13Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
39.13Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
39.13Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
39.13Single9UYMChemerin-99UYM-CML2-Chemerin-9-chim(Arrestin3-CtArrestin2)
39.13Consensuscck_onOrthosteric Ligandccka_on cckb_on
39.13Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
39.13Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
39.13Consensusprostanoid_offOrthosteric Ligandep_off dp_off
38.89Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
38.89Single9KUWCMPD6449KUW-Apelin; Apelin-CMPD644-Arrestin2 ; Arrestin2
38.71Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
38.46Single3OE0CVX153OE0-CXCR4-CVX15
38.46Single5WF5UK-4320975WF5-A2A-UK-432097
38.46Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
38.46Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
38.46Single8XZHMM078XZH-Apelin; Apelin-MM07-Gi1/β1/γ2
38.46Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
38.46Single9UYIChemerin-99UYI-CML2-Chemerin-9-Arrestin2
38.46Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
38.46Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-14-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
38.10Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
38.10Single7C61Ergotamine7C61-5-HT1B-Ergotamine
38.10Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
38.10Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
38.10Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
38.10Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
38.10Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
38.10Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
38.10Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
38.10Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
38.10Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
38.10Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.10Single8S4DCMF-0198S4D-Apelin-CMF-019
38.10Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.10Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.10Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
38.10Single9IYBPGD29IYB-DP2-PGD2-A1D5Q-Gi1/β1/γ2
38.10Consensusa3_on_gpOrthosteric Liganda3a_on_gp
38.10Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
38.10Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
38.10Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
38.10Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
38.10Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-2-Phenylethylamine-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs)/β1/γ2
38.10Consensustrace-amine_onOrthosteric Ligandta1_on
37.93Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
37.93Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
37.93Single9KDFRES-701-39KDF-ETB-RES-701-3
37.50Single3NY9PubChem 9131033NY9-β2-PubChem 913103
37.50Single4UG2CGS216804UG2-A2A-CGS21680
37.50Single5WF6UK-4320975WF6-A2A-UK-432097
37.50Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
37.50Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
37.50Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
37.50Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
37.50Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
37.50Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
37.50Single7XN9L-0545227XN9-SST2-L-054522
37.50Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
37.50Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
37.50Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
37.50Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
37.50Single8Z74JN241-98Z74-Apelin; Apelin-JN241-9
37.50Single8Z74JN241-98Z74-Apelin; Apelin-JN241-9
37.50Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
37.50Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
37.50Single9M0RNeuropeptide-VF9M0R-NPFF1-Neuropeptide-VF-Gi1/β1/γ2
37.50Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Sulfated Gastrin-(10-17)-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
37.50Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
37.50Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
37.50Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
37.04Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
37.04Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
37.04Single8XZJWN3538XZJ-Apelin; Apelin-WN353-Gi1/β1/γ2
37.04Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
37.04Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMIFL-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-TC-FPR 43-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
36.84Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
36.84Single6ME2Ramelteon6ME2-MT1-Ramelteon
36.84Single6ME9Ramelteon6ME9-MT2-Ramelteon
36.84Single6OBAAlprenolol6OBA-β2-Alprenolol-GTPL11074
36.84Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
36.84Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
36.84Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.84Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
36.84Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
36.84Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
36.84Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
36.84Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
36.84Single8IW4Spermidine8IW4-TAA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
36.84Single8IWESpermidine8IWE-TAA9-Spermidine
36.84Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
36.84Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
36.84Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
36.84Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
36.84Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
36.84Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
36.84Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
36.84Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
36.84Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
36.84Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
36.67Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
36.67Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
36.67Single8IY6Endothelin-18IY6-ETB-Endothelin-1
36.67Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
36.67Consensusendothelin_onOrthosteric Ligandetb_on eta_on
36.36Single2YDVNECA2YDV-A2A-NECA
36.36Single3P0GBI1671073P0G-β2-BI167107
36.36Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
36.36Single4LDLHydroxybenzyl Isoproterenol4LDL-β2-Hydroxybenzyl Isoproterenol
36.36Single4UHRCGS216804UHR-A2A-CGS21680
36.36Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
36.36Single5G53NECA5G53-A2A-NECA-Gs
36.36Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
36.36Single6OS1TRV0266OS1-AT1-TRV026
36.36Single6WGTLSD6WGT-5-HT2A-LSD
36.36Single7B6WCyclazosin7B6W-α1b-Cyclazosin
36.36Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
36.36Single7M8W15r-Methyl-PGD27M8W-DP2-15r-Methyl-PGD2-Na
36.36Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
36.36Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
36.36Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
36.36Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
36.36Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
36.36Single8WU1MDMB-Fubinaca8WU1-CB1-MDMB-Fubinaca-Arrestin2
36.36Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
36.36Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
36.36Single9KVPSB2901579KVP-C3aB-SB290157-Go/β1/γ2
36.36Single9WSTDAMGO9WST-μ-DAMGO-chim(NtGi1-Gz)/β1/γ2
36.36Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
36.36Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
36.36Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
36.36Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoprenaline-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
36.36Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
36.36Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-2-Phenylethylamine-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs)/β1/γ2
36.36Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
36.00Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
36.00Single7F8XNN90567F8X-CCKA-NN9056
36.00Single7L0RNeurotensin-(8-13)7L0R-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
36.00Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
36.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
36.00Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
36.00Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
36.00Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
36.00Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
36.00Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
36.00Single9KWGC5a9KWG-C5a1-C5a-Go/β1/γ2
36.00Single9L3YChemerin9L3Y-CML2-Chemerin-Gi1/β1/γ2
36.00Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
36.00Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
36.00Consensussomatostatin_offOrthosteric Ligandsst2_off
35.71Single7F9YGhrelin7F9Y-Ghrelin-Ghrelin-chim(NtGi1-Gs-CtGq)/β1/γ2
35.71Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
35.71Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
35.71Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.71Single8HK5C5a8HK5-C5a1-C5a-Gi1/β1/γ2
35.71Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
35.71Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
35.71Single8ZRTEndothelin-18ZRT-ETB-Endothelin-1
35.71Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
35.71Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
35.48Single8ZJETAK4488ZJE-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ1
35.48Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-CCL3-Gi1/β1/γ2
35.48Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
35.00Single4LDOEpinephrine4LDO-β2-Epinephrine
35.00Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
35.00Single6KUXRS799486KUX-α2a-RS79948
35.00Single6MH8ZM-2413856MH8-A2A-ZM-241385
35.00Single6PS0Carazolol6PS0-β2-Carazolol
35.00Single6PS4ICI118-5516PS4-β2-ICI118-551
35.00Single6PS5Propranolol6PS5-β2-Propranolol
35.00Single7AROLUF58337ARO-A2A-LUF5833-Na
35.00Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
35.00Single7F61PF-036547467F61-H3-PF-03654746
35.00Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
35.00Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
35.00Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
35.00Single8GE5Constrained Epinephrine8GE5-β2-Constrained Epinephrine-Gs/β1/γ1
35.00Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
35.00Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
35.00Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
35.00Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
35.00Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
35.00Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.00Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.00Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
35.00Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
35.00Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
35.00Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
35.00Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
35.00Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
35.00Single8GURCP559408GUR-CB2-CP55940-Gi1/β1/γ2
35.00Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
35.00Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
35.00Single8K9KDAMGO8K9K-μ-DAMGO-Gi3/β1/γ1
35.00Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
35.00Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
35.00Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
35.00Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.00Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.00Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
35.00Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
35.00Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
35.00Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
35.00Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
35.00Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
35.00Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
35.00Single9JH3CMF-0199JH3-Apelin; Apelin-CMF-019-Gi1/β1/γ2
35.00Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
35.00Single9L84Epinephrine9L84-β1-Epinephrine-Atazanavir-Gs/β1/γ2
35.00Single9L8LBI1671079L8L-β2-BI167107-Atazanavir-Gs/β1/γ2 ; Arrestin2
35.00Single9VNFPindolol9VNF-5-HT1A-Pindolol-Go/β1/γ2
35.00Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
35.00Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
35.00Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
35.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
34.78Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
34.78Single4AMIBucindolol4AMI-β1-Bucindolol
34.78Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
34.78Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
34.78Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
34.78Single6YVRNeurotensin-(6-13)6YVR-NTS1-Neurotensin-(6-13)
34.78Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
34.78Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
34.78Single7W0LPubChem 1227019087W0L-Apelin; Apelin-PubChem 122701908-Gi1/β1/γ2
34.78Single7W0LPubChem 1227019087W0L-Apelin; Apelin-PubChem 122701908-Gi1/β1/γ2
34.78Single7W0NElabela7W0N-Apelin; Apelin-Elabela-Gi1/β1/γ2
34.78Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
34.78Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
34.78Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
34.78Single8HK2C3a8HK2-C3aB-C3a-Gi1/β1/γ2
34.78Single8ID9Icosapent8ID9-FFA4-Icosapent-Gi1/β1/γ2
34.78Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
34.78Single8JJ8Arformoterol8JJ8-β2-Arformoterol
34.78Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
34.78Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
34.78Single8T3QDoconexent8T3Q-FFA4-Doconexent-chim(NtGi2L-Gs-CtGq)/β1/γ2
34.78Single8U26Substance-P8U26-NK1-Substance-P-Gs/β1/γ2
34.78Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
34.78Single9M4QDoxazosin9M4Q-Alpha1A-Doxazosin
34.78Single9V6ONalfurafine9V6O-κ-Nalfurafine-Gi1/β1/γ2
34.78Single9WSVDAMGO9WSV-μ-DAMGO-Arrestin2
34.78Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-PtdIns4P-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-PtdIns4P-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-PtdIns4P-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-PtdIns4P-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-PtdIns4P-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-PtdIns4P-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-PtdIns4P-Gi1/β1/γ1
34.78Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-PtdIns4P-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-PtdIns4P-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-PtdIns4P-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-PtdIns4P-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-PtdIns4P-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-PtdIns4P-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-PtdIns4P-Gi1/β1/γ1
34.78Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
34.78Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
34.78Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
34.78Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
34.78Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
34.78Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
34.78Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
34.78Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
34.78Consensuslpa_offOrthosteric Ligandlpa1_off
34.78Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
34.78Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
34.78Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
34.78Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
34.78Consensusorexin_onOrthosteric Ligandox2_on
34.62Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
34.62Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
34.62Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
34.62Single9E82CXCL12 (fragment)9E82-ACKR3-CXCL12 (fragment)-Arrestin2
34.62Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
34.62Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
34.62Single9L60Dynorphin9L60-κ-Dynorphin-MPAM-15-Gi1/β1/γ2
34.62Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Sulfated Gastrin-(10-17)-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
34.62Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
34.48Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
34.48Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
34.48Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
34.48Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
34.48Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
34.38Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
34.38Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
33.33Single2Y02Carmoterol2Y02-β1-Carmoterol
33.33Single2Y04Salbutamol2Y04-β1-Salbutamol
33.33Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
33.33Single3NY8ICI118-5513NY8-β2-ICI118-551
33.33Single3ZPQPubChem 5945903ZPQ-β1-PubChem 594590-Na
33.33Single4BUONeurotensin-(8-13)4BUO-NTS1-Neurotensin-(8-13)
33.33Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
33.33Single4EJ4Naltrindole4EJ4-δ-Naltrindole
33.33Single4GBRCarazolol4GBR-β2-Carazolol
33.33Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
33.33Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
33.33Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
33.33Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
33.33Single6DDFDAMGO6DDF-μ-DAMGO-Gi1/β1/γ2
33.33Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
33.33Single6H7MSalbutamol6H7M-β1-Salbutamol
33.33Single6PS1Timolol6PS1-β2-Timolol
33.33Single6PS2Alprenolol6PS2-β2-Alprenolol
33.33Single6UP7Neurotensin-(8-13)6UP7-NTS1-Neurotensin-(8-13)-Arrestin2
33.33Single7BTSEpinephrine7BTS-β1-Epinephrine
33.33Single7BU6Norepinephrine7BU6-β1-Norepinephrine
33.33Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
33.33Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
33.33Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
33.33Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
33.33Single7JOZPubChem 752020227JOZ-D1-PubChem 75202022-Gs/β1/γ2
33.33Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
33.33Single7LJCSKF812977LJC-D1-SKF81297-Mevidalen-Gs/β1/γ2
33.33Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
33.33Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
33.33Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
33.33Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
33.33Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
33.33Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
33.33Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
33.33Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
33.33Single7WC7Lisuride7WC7-5-HT2A-Lisuride
33.33Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
33.33Single7XJHIsoprenaline7XJH-β3-Isoprenaline-Gs/β1/γ2
33.33Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
33.33Single8FN0Neurotensin-(8-13)8FN0-NTS1-Neurotensin-(8-13)-SBI-553-chim(NtGi1-Go)/β1/γ2
33.33Single8GE2Constrained Epinephrine8GE2-β2-Constrained Epinephrine-Gs/β1/γ1
33.33Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
33.33Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
33.33Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
33.33Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
33.33Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
33.33Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
33.33Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
33.33Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
33.33Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
33.33Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
33.33Single8J6PNiacin8J6P-HCA2-Niacin-PubChem 25101223-Gi1/β1/γ2
33.33Single8JHNMonomethyl fumarate8JHN-HCA2-Monomethyl fumarate-Go/β1/γ2
33.33Single8JXRLSD8JXR-D1-LSD
33.33Single8PJKST1718PJK-5-HT1A-ST171-Gi1/β1/γ1
33.33Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
33.33Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
33.33Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
33.33Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
33.33Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
33.33Single8XZGApelin-138XZG-Apelin; Apelin-Apelin-13-Gi1/β1/γ2
33.33Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
33.33Single8ZH8QRFP268ZH8-QRFP-QRFP26-Gq/β1/γ1
33.33Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
33.33Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
33.33Single9KUGEP679KUG-C5a1-EP67-Go/β1/γ2
33.33Single9KV8TLQP219KV8-C3aB-TLQP21-Go/β1/γ2
33.33Single9KWXC5a-des-Arg9KWX-C5a1-C5a-des-Arg-Go/β1/γ2
33.33Single9M54Neuropeptide-VF9M54-NPFF2-Neuropeptide-VF-Gi1/β1/γ2
33.33Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
33.33Single9UYHChemerin-99UYH-CML2-Chemerin-9-Arrestin2
33.33Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
33.33Consensus5ht5_onOrthosteric Ligand5ht5a_on
33.33Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
33.33Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
33.33Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-C5a-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a-Gi1/β1/γ2
33.33Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
33.33Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
33.33Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Sulfated Gastrin-(10-17)-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
33.33Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
33.33Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
33.33Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
33.33Consensusdopamine_offOrthosteric Ligandd2_off d3_off
33.33Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
33.33Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
33.33Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-TC-FPR 43-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
33.33Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-Monomethyl fumarate-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
33.33Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
33.33Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
33.33Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-2-Phenylethylamine-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
33.33Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-Monomethyl fumarate-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
33.33Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-Monomethyl fumarate-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
33.33Consensushca_on_gpOrthosteric Ligandhca2_on_gp
33.33Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
32.35Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
32.26Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
32.14Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
32.14Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
32.14Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
32.14Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
32.14Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
32.14Single8WSTMCH8WST-MCH2-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
32.14Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-C5a-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a-Gi1/β1/γ2
32.14Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-TC-FPR 43-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
32.00Single6KNMJN241-96KNM-Apelin-JN241-9
32.00Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
32.00Single6PT3DPI-2876PT3-δ-DPI-287
32.00Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
32.00Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
32.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
32.00Single9IPYJR14a9IPY-C3aB-JR14a
32.00Single9KZ2EP679KZ2-C3aB-EP67-Go/β1/γ2
32.00Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
32.00Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
32.00Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Single2RH1Carazolol2RH1-β2-Carazolol
31.82Single2Y03Isoprenaline2Y03-β1-Isoprenaline
31.82Single2YCWCarazolol2YCW-β1-Carazolol
31.82Single5C1MBU725C1M-μ-BU72
31.82Single5D6LCarazolol5D6L-β2-Carazolol
31.82Single5JQHCarazolol5JQH-β2-Carazolol
31.82Single5N2RPSB365N2R-A2A-PSB36-Na
31.82Single5N2SPSB365N2S-A1-PSB36
31.82Single5TVNLSD5TVN-5-HT2B-LSD
31.82Single5WQCEMPA5WQC-OX2-EMPA
31.82Single5X7DCarazolol5X7D-β2-Carazolol-PubChem 129318963
31.82Single6E67BI1671076E67-β2-BI167107-Gs(CT)
31.82Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
31.82Single6PS3Carvedilol6PS3-β2-Carvedilol
31.82Single7BVQCarazolol7BVQ-β1-Carazolol
31.82Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
31.82Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
31.82Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
31.82Single7WIGL-0542647WIG-SST2-L-054264-Gi1/β1/γ2
31.82Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
31.82Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
31.82Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
31.82Single8JXSPF-61428JXS-D1-PF-6142
31.82Single8TF5Oleic acid8TF5-GPR6-Oleic acid
31.82Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
31.82Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
31.82Single8ZMFPubChem 1719206738ZMF-5-HT2C-PubChem 171920673
31.82Single8ZRKGSK12922638ZRK-GPR119-GSK1292263-Gs/β1/γ2
31.82Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
31.82Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
31.82Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
31.82Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
31.82Single9EHSLUF76029EHS-A3A-LUF7602
31.82Single9F33FOB02-04A9F33-D3-FOB02-04A-Go/β1/γ2
31.82Single9F34FOB02-04A9F34-D3-FOB02-04A-Go/β1/γ2
31.82Single9HAPTolvaptan9HAP-V2-Tolvaptan
31.82Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
31.82Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.82Single9PXYNaloxone9PXY-μ-Naloxone-GDPβS-Gi1/β1/γ2
31.82Single9U81Tolvaptan9U81-V2-Tolvaptan
31.82Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
31.82Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
31.82Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
31.82Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
31.82Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
31.82Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
31.82Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
31.82Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
31.82Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
31.82Consensusamine_offonOrthosteric Ligandamine_off amine_on
31.82Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
31.82Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
31.82Consensusbeta2_offOrthosteric Ligand2RH1-β2-Carazolol 6PS3-β2-Carvedilol 6PS5-β2-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-PubChem 913103 6PRZ-β2-Alprenolol
31.82Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
31.82Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-AM12033-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
31.82Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-AM12033-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
31.82Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
31.82Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
31.58Single6HLLCP999946HLL-NK1-CP99994
31.58Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
31.58Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
31.58Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
31.58Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
31.58Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
31.58Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
31.58Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
31.58Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
31.58Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
31.58Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
31.58Single9U9VMETH9U9V-β2-METH-Gs/β1/γ2
31.58Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
31.58Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
31.25Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
31.03Single7P02Substance-P7P02-NK1-Substance-P-chim(NtGi1-Gs)/β1/γ2
31.03Single8IA2C5a8IA2-C5a1-C5a-Go/β1/γ2
31.03Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
31.03Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
31.03Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
31.03Single9JFYNeuropeptide-SF9JFY-NPFF2-Neuropeptide-SF-Gi1/β1/γ2
31.03Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
31.03Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
31.03Consensuspac_onOrthosteric Ligandpac1_on
30.77Single4AMJCarvedilol4AMJ-β1-Carvedilol
30.77Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
30.77Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
30.77Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
30.77Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
30.77Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
30.77Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
30.77Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
30.77Single9MEJGp1209MEJ-CXCR4-Gp120
30.77Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
30.77Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-C5-guano-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-DAMGO-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
30.77Consensuslpl_onOrthosteric Ligands1p_on lpa_on
30.77Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
30.77Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
30.77Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
30.77Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
30.43Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
30.43Single5D5ACarazolol5D5A-β2-Carazolol
30.43Single5D5BCarazolol5D5B-β2-Carazolol
30.43Single5XR8AM120335XR8-CB1-AM12033
30.43Single6DDEDAMGO6DDE-μ-DAMGO-Gi1/β1/γ2
30.43Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
30.43Single6H7JIsoprenaline6H7J-β1-Isoprenaline
30.43Single6J21Aprepitant6J21-NK1-Aprepitant
30.43Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
30.43Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
30.43Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
30.43Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-PtdIns4P-Gi1/β1/γ2
30.43Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
30.43Single7F1TCCL37F1T-CCR5-CCL3
30.43Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
30.43Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
30.43Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
30.43Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
30.43Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
30.43Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
30.43Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.43Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.43Single7XOWSulfated Gastrin-(10-17)7XOW-CCKB-Sulfated Gastrin-(10-17)-chim(NtGi1-Gq)/β1/γ2
30.43Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
30.43Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
30.43Single8FN1Neurotensin-(8-13)8FN1-NTS1-Neurotensin-(8-13)-chim(NtGi1-Go)/β1/γ2
30.43Single8HQCC5a8HQC-C5a1-C5a-Go/β1/γ2
30.43Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
30.43Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
30.43Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
30.43Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
30.43Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
30.43Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
30.43Single8JZPC5a8JZP-C5a1-C5a-Go/β1/γ2
30.43Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
30.43Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
30.43Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
30.43Single8XZICMF-0198XZI-Apelin; Apelin-CMF-019-Gi1/β1/γ2
30.43Single8ZWFJR14a8ZWF-C3aB-JR14a
30.43Single9BJKNaloxone9BJK-μ-Naloxone-PubChem 171642066
30.43Single9BS9LSD9BS9-D2-LSD
30.43Single9BSBLSD9BSB-D2-LSD-chim(NtGi1-Go)/β1/γ2
30.43Single9I54PubChem 1764520919I54-D1-PubChem 176452091-Gs/β1/γ2
30.43Single9KUXCMPD6449KUX-Apelin; Apelin-CMPD644-Arrestin2
30.43Single9MENGp120 (V3 loop)9MEN-CXCR4-Gp120 (V3 loop)
30.43Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
30.43Consensusa2_onOrthosteric Liganda2b_on
30.43Consensusa2_on_gpOrthosteric Liganda2b_on_gp
30.43Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
30.43Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
30.43Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
30.43Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-PubChem 594590-Na 3ZPR-β1-PubChem 598754-Na
30.43Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
30.43Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
30.43Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-PtdIns4P-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-PtdIns4P-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-PtdIns4P-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-PtdIns4P-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-PtdIns4P-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-PtdIns4P-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-PtdIns4P-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
30.43Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-AM12033-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
30.43Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
30.43Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
30.43Consensusneurotensin_onOrthosteric Ligandnts1_on
30.43Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
30.43Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
30.43Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
30.43Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
30.30Single6LPBPACAP276LPB-PAC1-PACAP27-Gs/β1/γ1
30.30Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
30.00Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
30.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
30.00Single4XT3CX3CL14XT3-US28-CX3CL1
30.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
30.00Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
30.00Single6AKXA4R6AKX-CCR5-A4R
30.00Single6AKYMaraviroc6AKY-CCR5-Maraviroc
30.00Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
30.00Single6TODEMPA6TOD-OX1-EMPA-Na
30.00Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
30.00Single7F8ULintitript7F8U-CCKA-Lintitript
30.00Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
30.00Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
30.00Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
30.00Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
30.00Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
30.00Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
30.00Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
30.00Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
30.00Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
30.00Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.00Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
30.00Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
30.00Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
30.00Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
30.00Single9P92VIP9P92-PAC1-VIP-Gs/β1/γ2
30.00Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
30.00Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
30.00Consensusalpha2_offOrthosteric Ligandalpha2c_off
30.00Consensusangiotensin_offOrthosteric Ligandat1_off
30.00Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
30.00Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
30.00Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
30.00Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
30.00Consensusorexin_offOrthosteric Ligandox2_off ox1_off
30.00Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
29.63Single6HLOAprepitant6HLO-NK1-Aprepitant
29.63Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
29.63Single7RKMCX3CL17RKM-US28-CX3CL1-Gi1/β1/γ2
29.63Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
29.63Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
29.63Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Single8K6ONeuropeptide-Y8K6O-Y1-Neuropeptide-Y-Gi2/β1/γ1
29.63Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
29.63Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
29.63Single9JFK(Pen5)-Urotensin II9JFK-UT-(Pen5)-Urotensin II-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.63Single9KT7MK68929KT7-HCA2-MK6892-Gi1/β1/γ2
29.63Single9KV6TLQP219KV6-C3aB-TLQP21-Go/β1/γ2
29.63Single9UMXEP549UMX-C5a1-EP54-Go/β1/γ2
29.63Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
29.63Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
29.63Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
29.63Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
29.17Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
29.17Single3D4STimolol3D4S-β2-Timolol
29.17Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
29.17Single4LDEBI1671074LDE-β2-BI167107
29.17Single4XEENeurotensin-(8-13)4XEE-NTS1-Neurotensin-(8-13)
29.17Single4XESNeurotensin-(8-13)4XES-NTS1-Neurotensin-(8-13)
29.17Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
29.17Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
29.17Single6A93Risperidone6A93-5-HT2A-Risperidone
29.17Single6H7NXamoterol6H7N-β1-Xamoterol
29.17Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
29.17Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
29.17Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
29.17Single7L0SNeurotensin-(8-13)7L0S-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
29.17Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
29.17Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
29.17Single7YITNalfurafine7YIT-κ-Nalfurafine
29.17Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-PtdIns4P-Gi1/β1/γ1
29.17Single8FYTLSD8FYT-5-HT1A-LSD-PtdIns4P-Gi1/β1/γ1
29.17Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
29.17Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Single8XWSCXCL58XWS-CXCR2-CXCL5
29.17Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
29.17Single9ECJS-geranylgeranyl-L-glutathione9ECJ-P2Y8-S-geranylgeranyl-L-glutathione-G13/β1/γ2
29.17Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
29.17Single9KVG5-MeO-DMT9KVG-5-HT1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ2
29.17Single9KZKC3a (fragment)9KZK-C3aB-C3a (fragment)-Go/β1/γ2
29.17Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
29.17Single9VIFNeuropeptide-VF9VIF-NPFF1-Neuropeptide-VF-Gi1/β1/γ2
29.17Single9WXMGPR15L(CT)9WXM-GPR15-GPR15L(CT)-Gi3/β1/γ2
29.17Single9YDQDADLE9YDQ-δ-DADLE-MIPS3614-chim(NtGi1L-Gs-CtGi1)/β1/γ2
29.17Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
29.17Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
29.17Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
29.17Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
29.17Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
29.17Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
29.17Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
29.17Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
29.17Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
29.17Consensuslpl_offOrthosteric Ligands1p_off lpa_off
29.17Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
29.17Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
29.17Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
29.17Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
29.03Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
29.03Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
29.03Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
29.03Consensusglp_onOrthosteric Ligandglp1_on glp2_on
29.03Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
28.57Single2YDOAdenosine2YDO-A2A-Adenosine
28.57Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
28.57Single4MBSMaraviroc4MBS-CCR5-Maraviroc
28.57Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
28.57Single4ZJCSB-6740424ZJC-OX1-SB-674042
28.57Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
28.57Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
28.57Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
28.57Single6A94Zotepine6A94-5-HT2A-Zotepine
28.57Single6PT2KGCHM076PT2-δ-KGCHM07
28.57Single6TPNHTL66416TPN-OX2-HTL6641
28.57Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
28.57Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
28.57Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
28.57Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
28.57Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
28.57Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
28.57Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
28.57Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.57Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.57Single7T32ZM-2413857T32-A2A-ZM-241385
28.57Single7T94LY21196207T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
28.57Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
28.57Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
28.57Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
28.57Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
28.57Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
28.57Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
28.57Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
28.57Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
28.57Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
28.57Single8JIMMonomethyl fumarate8JIM-HCA2-Monomethyl fumarate-Gi1/β1/γ2
28.57Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
28.57Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
28.57Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
28.57Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
28.57Single8K6NNeuropeptide-Y8K6N-Y2-Neuropeptide-Y-Gi2/β1/γ1
28.57Single8THKA-616038THK-Alpha1A-A-61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.57Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.57Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
28.57Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
28.57Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
28.57Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
28.57Single9AS5Mescaline9AS5-5-HT2A-Mescaline
28.57Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
28.57Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
28.57Single9LL8Psilocin9LL8-5-HT2A-Psilocin-Gi1/β1/γ2
28.57Single9M1ONeuropeptide-FF9M1O-NPFF2-Neuropeptide-FF-Gi1/β1/γ2
28.57Single9P1TZM-2413859P1T-A2A-ZM-241385
28.57Single9PXVNaloxone9PXV-μ-Naloxone-Gi1/β1/γ2
28.57Single9PXXNaloxone9PXX-μ-Naloxone-GDPβS-Gi1/β1/γ2
28.57Single9VJG8-OH-DPAT9VJG-5-HT1A-8-OH-DPAT-chim(NtGi2-Gz)/β1/γ2
28.57Single9W6W5-CT9W6W-5-HT5A-5-CT-Gi1/β1/γ2
28.57Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
28.57Consensusalpha1_onOrthosteric Ligandalpha1a_on
28.57Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
28.57Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
28.57Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
28.57Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
28.57Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
28.57Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
28.57Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
28.57Consensushca_onOrthosteric Ligandhca2_on
28.57Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
28.57Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
28.12Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
28.12Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
28.12Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
28.12Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
28.12Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
28.12Single9P93VIP9P93-PAC1-VIP-Gs/β1/γ2
28.12Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
28.12Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
28.00Single5X93K-87945X93-ETB-K-8794
28.00Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
28.00Single6H7LDobutamine6H7L-β1-Dobutamine
28.00Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
28.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
28.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
28.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.00Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
28.00Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
28.00Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
28.00Single7UM4AS26747237UM4-5-HT5A-AS2674723
28.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
28.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
28.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
28.00Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
28.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
28.00Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
28.00Single8JPFNeurotensin-(8-13)8JPF-NTS1-Neurotensin-(8-13)-SBI-553
28.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
28.00Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
28.00Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
28.00Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.00Single8XGSKisspeptin-18XGS-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ2
28.00Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
28.00Single8ZPLHF511168ZPL-CXCR4-HF51116
28.00Single9AS02-bromo-LSD9AS0-5-HT2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
28.00Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
28.00Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
28.00Single9HYIDP819HYI-5-HT1A-DP81-Gi1/β1/γ2
28.00Single9IZFLPA9IZF-LPA1-LPA-Gi1/β1/γ2
28.00Single9KT8Acifran9KT8-HCA2-Acifran-Gi1/β1/γ2
28.00Single9L79AR2314539L79-GPR119-AR231453-chim(NtGi1-Gs)/β1/γ2
28.00Single9VI9RFRP-39VI9-NPFF1-RFRP-3-Gi1/β1/γ2
28.00Single9YDPDADLE9YDP-δ-DADLE-chim(NtGi1L-Gs-CtGi1)/β1/γ2
28.00Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
28.00Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
28.00Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
28.00Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
28.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
28.00Consensusendothelin_offOrthosteric Ligandetb_off
28.00Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
28.00Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM-5541-Gi1/β1/γ2 7EW2-S1P3-FTY720-P-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
28.00Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
28.00Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
28.00Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
27.78Single8A2OTheophylline8A2O-A2A-Theophylline-Na
27.78Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.78Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
27.78Single8IWM2-Phenylethylamine8IWM-TAA9-2-Phenylethylamine
27.78Single9CHUNorepinephrine9CHU-β2-Norepinephrine
27.78Single9EE9Adenosine9EE9-A2A-Adenosine-Gs/β1/γ2
27.78Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
27.78Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
27.59Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
27.59Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
27.59Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
27.59Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
27.59Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
27.59Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
27.59Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
27.59Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
27.59Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
27.59Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
27.59Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
27.59Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
27.59Consensusvasop-oxy_onOrthosteric Ligandv2_on
27.59Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
27.27Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
27.27Single2Y01Dobutamine2Y01-β1-Dobutamine
27.27Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
27.27Single3EMLZM-2413853EML-A2A-ZM-241385
27.27Single3NYAAlprenolol3NYA-β2-Alprenolol
27.27Single3ZPRPubChem 5987543ZPR-β1-PubChem 598754-Na
27.27Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
27.27Single4YAYZD-71554YAY-AT1-ZD-7155
27.27Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
27.27Single5UENDU1725UEN-A1-DU172
27.27Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
27.27Single5ZKPSR274175ZKP-PAF-SR27417
27.27Single6DRXLisuride6DRX-5-HT2B-Lisuride
27.27Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
27.27Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
27.27Single6PRZAlprenolol6PRZ-β2-Alprenolol
27.27Single6S0LZM-2413856S0L-A2A-ZM-241385
27.27Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
27.27Single7BU7BI1671077BU7-β1-BI167107
27.27Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
27.27Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
27.27Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
27.27Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
27.27Single7UL4Alvimopan7UL4-μ-Alvimopan
27.27Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
27.27Single7V3ZCP559407V3Z-CB1-CP55940
27.27Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
27.27Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
27.27Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
27.27Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
27.27Single8CU6LJ-45178CU6-A2A-LJ-4517
27.27Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
27.27Single8EFQDAMGO8EFQ-μ-DAMGO-Gi1/β1/γ2
27.27Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ1
27.27Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
27.27Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
27.27Single8JIINiacin8JII-HCA2-Niacin-PubChem 25101223-Gi1/β1/γ2
27.27Single8JJOAlprenolol8JJO-β2-Alprenolol
27.27Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
27.27Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
27.27Single8K5DGSK2560738K5D-HCA2-GSK256073
27.27Single8T1WCVN4248T1W-GPR6-CVN424
27.27Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
27.27Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
27.27Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
27.27Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
27.27Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
27.27Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
27.27Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
27.27Single8Y71A1D6F8Y71-δ-A1D6F-BMS986187-Gi1/β1/γ2
27.27Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
27.27Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
27.27Single8ZQEGPR15L(CT)8ZQE-GPR15-GPR15L(CT)-Gi1/β1/γ1
27.27Single9AS1DMT9AS1-5-HT2A-DMT
27.27Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
27.27Single9DYFAsenapine9DYF-5-HT1A-Asenapine-PtdIns4P-Gi1/β1/γ2
27.27Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
27.27Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
27.27Single9P1SZM-2413859P1S-A2A-ZM-241385
27.27Single9PLNPubChem 1682595949PLN-α2a-PubChem 168259594
27.27Single9PLOPubChem 1682595949PLO-α2a-PubChem 168259594-Go/β1/γ2
27.27Single9PQDPubChem 1764919279PQD-α2a-PubChem 176491927
27.27Single9PXWNaloxone9PXW-μ-Naloxone-GDPβS-Gi1/β1/γ2
27.27Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
27.27Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
27.27Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
27.27Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
27.27Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
27.27Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
27.27Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
27.27Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
27.27Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
27.03Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
27.03Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
26.92Single5ZTYAM102575ZTY-CB2-AM10257
26.92Single7RKFCX3CL17RKF-US28-CX3CL1-GDP-chim(NtGi1-G11)/β1/γ2
26.92Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
26.92Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
26.92Single7SK9CCX6627SK9-ACKR3-CCX662
26.92Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
26.92Single8QJ2pN1628QJ2-MC4-pN162-Gs/β1/γ2
26.92Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
26.92Single8XQJJN2418XQJ-Apelin; Apelin-JN241
26.92Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
26.92Single8XZFWN5618XZF-Apelin; Apelin-WN561-Gi1/β1/γ2
26.92Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
26.92Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
26.92Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
26.92Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ1
26.92Consensuskisspeptin_onOrthosteric Ligandkiss1_on
26.92Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
26.92Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
26.67Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
26.67Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
26.67Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
26.67Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
26.67Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
26.67Single9E2AGLP-19E2A-GLP-1-GLP-1-Gs/β1/γ2
26.67Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
26.67Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
26.67Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-CXCL8-Gi1/β1/γ2 6LFM-CXCR2-CXCL8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-CCL3-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
26.67Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
26.67Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
26.67Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
26.47Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
26.47Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
26.32Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
26.32Single6PWCNeurotensin-(9-13)6PWC-NTS1-Neurotensin-(9-13)-Arrestin2
26.32Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
26.32Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
26.32Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
26.32Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.32Single8IW72-Phenylethylamine8IW7-TAA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
26.32Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
26.32Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-PubChem 25101223-Gi1/β1/γ2
26.32Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
26.32Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
26.32Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
26.32Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
26.32Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
26.32Single9LRCHistamine9LRC-H4-Histamine
26.32Single9LREHistamine9LRE-H4-Histamine-Gi1/β1/γ2
26.32Consensus5ht2_onOrthosteric Ligand5ht2b_on
26.32Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.32Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
26.32Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
26.32Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
26.09Single2Y00Dobutamine2Y00-β1-Dobutamine
26.09Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
26.09Single5IUAQ274563485IUA-A2A-Q27456348-Na
26.09Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
26.09Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
26.09Single5WIUNemonapride5WIU-D4-Nemonapride
26.09Single5WIVNemonapride5WIV-D4-Nemonapride-Na
26.09Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
26.09Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
26.09Single6KPCAM120336KPC-CB2-AM12033
26.09Single6LFMCXCL86LFM-CXCR2-CXCL8-Gi1/β1/γ2
26.09Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
26.09Single6PS6Timolol6PS6-β2-Timolol
26.09Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
26.09Single6S0QZM-2413856S0Q-A2A-ZM-241385
26.09Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
26.09Single6TP6Filorexant6TP6-OX1-Filorexant
26.09Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
26.09Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
26.09Single6Z4SSR486926Z4S-NTS1-SR48692
26.09Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
26.09Single7EPFNAM5977EPF-mGlu2-NAM597
26.09Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
26.09Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
26.09Single7W41PD1762527W41-BB2-PD176252
26.09Single7WC6LSD7WC6-5-HT2A-LSD
26.09Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
26.09Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
26.09Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
26.09Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
26.09Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
26.09Single8GNEKW-63568GNE-A2A-KW-6356-Na
26.09Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
26.09Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
26.09Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
26.09Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
26.09Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
26.09Single8QOTNanobody-E8QOT-μ-Nanobody-E
26.09Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
26.09Single8XYKVUF106618XYK-CXCR3-VUF10661-Go/β1/γ2
26.09Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
26.09Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
26.09Single8ZYTNeurotensin-(8-13)8ZYT-NTS1-Neurotensin-(8-13)-SBI-553-Arrestin2
26.09Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Single9DYDAsenapine9DYD-5-HT1A-Asenapine-PtdIns4P-Go/β1/γ2
26.09Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
26.09Single9L74S1P d16:19L74-S1P3-S1P d16:1-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.09Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
26.09Single9VJFBuspirone9VJF-5-HT1A-Buspirone-Gi3/β1/γ2
26.09Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
26.09Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
26.09Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
26.09Consensusadenosine_offOrthosteric Liganda1_off a2_off
26.09Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
26.09Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
26.09Consensusbombesin_offOrthosteric Ligandbb2_off
26.09Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-CXCL8-Gi1/β1/γ2
26.09Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
26.09Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
26.09Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
26.09Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
26.09Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
26.09Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
25.93Single4XT1CX3CL14XT1-US28-CX3CL1
25.93Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
25.93Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
25.93Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
25.93Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-PtdIns4P-Gi1/β1/γ1
25.93Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
25.93Single8PKMBefiradol8PKM-5-HT1A-Befiradol-Gi1/β1/γ1
25.93Single8WKYPG-9348WKY-MC4-PG-934
25.93Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.93Single8XBHPubChem 1626566368XBH-GPR34-PubChem 162656636-Gi1/β1/γ2
25.93Single8XWNCXCL88XWN-CXCR2-CXCL8
25.93Single8ZJDKisspeptin-18ZJD-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ1
25.93Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ1
25.93Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-1-chim(NtGi1-Gq)/β1/γ1
25.93Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
25.81Single6P9YPACAP276P9Y-PAC1-PACAP27-Gs/β1/γ2
25.81Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
25.81Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
25.81Single7SK3CXCL127SK3-ACKR3-CXCL12
25.81Single7VABTirzepatide (non-acylated)7VAB-GIP-Tirzepatide (non-acylated)-chim(NtGi1-Gs)/β1/γ2
25.81Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
25.81Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
25.81Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-CCL3-Gi1/β1/γ2
25.71Single6WPWZP37806WPW-Glucagon-ZP3780-Gs/β1/γ2
25.00Single3OE9IT1t3OE9-CXCR4-IT1t
25.00Single3PBLEticlopride3PBL-D3-Eticlopride
25.00Single3PDSFAUC503PDS-β2-FAUC50
25.00Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
25.00Single3ZEVNeurotensin-(7-13)3ZEV-NTS1-Neurotensin-(7-13)
25.00Single4U15Tiotropium4U15-M3-Tiotropium
25.00Single5TZRMK86665TZR-FFA1-MK8666
25.00Single5V54Methiothepin5V54-5-HT1B-Methiothepin
25.00Single5XRAAM115425XRA-CB1-AM11542
25.00Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
25.00Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
25.00Single6J20Aprepitant6J20-NK1-Aprepitant
25.00Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
25.00Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
25.00Single6OL9Tiotropium6OL9-M5-Tiotropium
25.00Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
25.00Single6TQ7SB-3348676TQ7-OX1-SB-334867
25.00Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
25.00Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
25.00Single7F1QCCL37F1Q-CCR5-CCL3-Gi1/β1/γ2
25.00Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
25.00Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
25.00Single7L0PNeurotensin-(8-13)7L0P-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
25.00Single7L0QNeurotensin-(8-13)7L0Q-NTS1-Neurotensin-(8-13)-Gi1/β1/γ1
25.00Single7PX4PSB-21137PX4-A2A-PSB-2113
25.00Single7S1MExendin-4-D-Ala7S1M-GLP-1-Exendin-4-D-Ala-Gs/β1/γ2
25.00Single7SK5CXCL127SK5-ACKR3-CXCL12
25.00Single7SRQLSD7SRQ-5-HT2B-LSD
25.00Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
25.00Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
25.00Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
25.00Single7TUYGSK682753A7TUY-GPR183-GSK682753A
25.00Single7VBITirzepatide (non-acylated)7VBI-GLP-1-Tirzepatide (non-acylated)-Gs/β1/γ2
25.00Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
25.00Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
25.00Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
25.00Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
25.00Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
25.00Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
25.00Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
25.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
25.00Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
25.00Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
25.00Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
25.00Single8FU6ZP37808FU6-Glucagon-ZP3780-Gs/β1/γ2
25.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
25.00Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
25.00Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
25.00Single8I2GPubChem 675302408I2G-FSH-FSH-PubChem 67530240-Gs/β1/γ2
25.00Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.00Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
25.00Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-PtdIns4P-Gi1/β1/γ2
25.00Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
25.00Single8K5BNiacin8K5B-HCA2-Niacin
25.00Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
25.00Single8W892-Phenylethylamine8W89-TA1-2-Phenylethylamine-chim(NtGi1L-Gs)/β1/γ2
25.00Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
25.00Single8XVLZibotentan8XVL-ETA-Zibotentan
25.00Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
25.00Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
25.00Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
25.00Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
25.00Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
25.00Single8YN7Immethridine8YN7-H3-Immethridine-Go/β1/γ2
25.00Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
25.00Single9AS2DMT9AS2-5-HT2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single9B65MDMB-Fubinaca9B65-CB1-MDMB-Fubinaca-Gi1/β1/γ2
25.00Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
25.00Single9IK8Pasireotide9IK8-SST1-Pasireotide-Gi1/β1/γ2
25.00Single9IK9Lanreotide9IK9-SST1-Lanreotide-Gi1/β1/γ2
25.00Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
25.00Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
25.00Single9IXJHistamine9IXJ-H2-Histamine-Gs/β1/γ2
25.00Single9IZGLPA9IZG-LPA1-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single9JEDHistamine9JED-H4-Histamine-PO4-Gi1/β1/γ2
25.00Single9JEQHistamine9JEQ-H3-Histamine-Gi1/β1/γ2
25.00Single9L16CCL219L16-CCR7-CCL21
25.00Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
25.00Single9L42Histamine9L42-H4-Histamine-Gi1/β1/γ2
25.00Single9P94PACAP279P94-PAC1-PACAP27-Gs/β1/γ2
25.00Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensus5ht1_offOrthosteric Ligand5ht1b_off
25.00Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
25.00Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
25.00Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
25.00Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.00Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
25.00Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
25.00Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
25.00Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
25.00Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
25.00Consensuslpa_onOrthosteric Ligandlpa1_on
25.00Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
25.00Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-methyl-Scopolamine 5ZHP-M3-PubChem 134828589
25.00Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
25.00Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
25.00Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
25.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
25.00Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
25.00Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM-5541-Gi1/β1/γ2 7EW2-S1P3-FTY720-P-Gi1/β1/γ2
25.00Consensustachykinin_offOrthosteric Ligandnk1_off
24.32Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
24.32Consensuspth_onOrthosteric Ligandpth1_on pth2_on
24.24Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
24.24Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
24.24Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
24.24Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
24.14Single6MEOGp160; CD46MEO-CCR5-Gp160; CD4
24.14Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
24.14Single6VN7PACAP276VN7-VPAC1-PACAP27-Gs/β1/γ2
24.14Single6W25SHU91196W25-MC4-SHU9119-Ca
24.14Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
24.14Single9B54VIP369B54-CB1-VIP36-Gi1/β1/γ2
24.14Single9LXRLA-PTH Analog9LXR-PTH1-LA-PTH Analog-Arrestin2
24.14Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
24.14Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
24.14Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
24.00Single5CXVTiotropium5CXV-M1-Tiotropium
24.00Single6CM4Risperidone6CM4-D2-Risperidone
24.00Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
24.00Single7DFPSpiperone7DFP-D2-Spiperone
24.00Single7EO4Siponimod7EO4-S1P1-Siponimod-Gi1/β1/γ2
24.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
24.00Single7K15MKD0467K15-BLT1-MKD046-Na
24.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
24.00Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
24.00Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
24.00Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
24.00Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
24.00Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
24.00Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
24.00Single8JWY2-1188JWY-A2A-2-118
24.00Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
24.00Single8XQJJN2418XQJ-Apelin; Apelin-JN241
24.00Single8XWACXCL18XWA-CXCR2-CXCL1
24.00Single8XWMCXCL68XWM-CXCR2-CXCL6
24.00Single8XYIVUF106618XYI-CXCR3-VUF10661
24.00Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
24.00Single9CM3TUG-13759CM3-FFA2-TUG-1375-PubChem 118615810-chim(NtGi1L-Gs-CtGq)/β1/γ2
24.00Single9DGIZ85267113509DGI-CB1-Z8526711350
24.00Single9GL2Befiradol9GL2-5-HT1A-Befiradol-Gs/β1/γ2
24.00Single9M8POleic monoethanolamide9M8P-GPR3 ; GPR3-Oleic monoethanolamide-AF64394
24.00Single9VJ6F-155999VJ6-5-HT1A-F-15599-Gi3/β1/γ2
24.00Single9WSWEndomorphin9WSW-μ-Endomorphin-chim(NtGi1-Gz)/β1/γ2
24.00Consensusalpha1_offOrthosteric Ligandalpha1a_off
24.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
24.00Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
24.00Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
24.00Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
24.00Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
24.00Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
24.00Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-C5-guano-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-DAMGO-Gi1/β1/γ2
24.00Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-C5-guano-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-DAMGO-Gi1/β1/γ2
24.00Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
24.00Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
23.81Single3PWHZM-2413853PWH-A2A-ZM-241385
23.81Single4BWBNeurotensin-(8-12)4BWB-NTS1-Neurotensin-(8-12)
23.81Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
23.81Single5WS3EMPA5WS3-OX2-EMPA
23.81Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
23.81Single6DS0LY2660976DS0-5-HT2B-LY266097
23.81Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
23.81Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
23.81Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
23.81Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
23.81Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
23.81Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
23.81Single7EJ0Norepinephrine7EJ0-α2a-Norepinephrine-Go/β1/γ2
23.81Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.81Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
23.81Single7T6STC-FPR 437T6S-FPR2-ALX-TC-FPR 43-Gi1/β1/γ2
23.81Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
23.81Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
23.81Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
23.81Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
23.81Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
23.81Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
23.81Single7XRRLemborexant7XRR-OX2-Lemborexant
23.81Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
23.81Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
23.81Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
23.81Single8FYXBuspirone8FYX-5-HT1A-Buspirone-PtdIns4P-Gi1/β1/γ1
23.81Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
23.81Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
23.81Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
23.81Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
23.81Single8TZQDopamine8TZQ-D2-Dopamine-Go/β1/γ2
23.81Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
23.81Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
23.81Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ2
23.81Single8YNFCXCL88YNF-ACKR1-CXCL8
23.81Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
23.81Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
23.81Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
23.81Single8Z87CHBA8Z87-HCA1-CHBA-Gi1/β1/γ2
23.81Single9JKXAcifran9JKX-HCA3-Acifran-Gi1/β1/γ2
23.81Single9KO2CCL199KO2-CCR7-CCL19-Gi1/β1
23.81Single9KO6CCL199KO6-CCR7-CCL19
23.81Single9KVHCinobufotenine9KVH-5-HT1A-Cinobufotenine-PtdIns4P-Gi1/β1/γ2
23.81Single9LL9DOI9LL9-5-HT2A-DOI-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.81Single9LLBDOI-NBOMe9LLB-5-HT2A-DOI-NBOMe-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.81Single9M88Oleic monoethanolamide9M88-GPR3 ; GPR3-Oleic monoethanolamide-AF64394
23.81Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
23.81Single9PXUNaloxone9PXU-μ-Naloxone-Na
23.81Single9VJ5Gepirone9VJ5-5-HT1A-Gepirone-Go/β1/γ2
23.81Single9VJEBuspirone9VJE-5-HT1A-Buspirone-Go/β1/γ2
23.81Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
23.81Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.81Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-CXCL8-Gi1/β1/γ2
23.81Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
23.81Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
23.81Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
23.81Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
23.81Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
23.81Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
23.81Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
23.81Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
23.81Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
23.81Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
23.53Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
23.53Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
23.53Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
23.53Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-1-Gs/β1/γ2
23.33Single6M1IPACAP276M1I-PAC1-PACAP27-Gs/β1/γ2
23.33Single6METGp160; CD46MET-CCR5-Gp160; CD4
23.33Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
23.33Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
23.33Single8IEDPubChem 1347468948IED-GPR156; GPR156-PubChem 134746894-Go/β1/γ2
23.33Single8IEDPubChem 1347468948IED-GPR156; GPR156-PubChem 134746894-Go/β1/γ2
23.33Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
23.33Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
23.26Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
23.08Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
23.08Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
23.08Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
23.08Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.08Single8GAGZ85267113508GAG-CB1-Z8526711350-Gi1/β1/γ2
23.08Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
23.08Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Single8WRZAM8418WRZ-CB1-AM841-Arrestin2
23.08Single8XBES3E-Lysophosphatidylserine 8XBE-GPR34-S3E-Lysophosphatidylserine-Gi1/β1/γ1
23.08Single8XVUCXCL28XVU-CXCR2-CXCL2
23.08Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
23.08Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
23.08Single9DYEBuspirone9DYE-5-HT1A-Buspirone-PtdIns4P-Go/β1/γ2
23.08Single9J0BUDP-Glucose9J0B-P2Y14-UDP-Glucose-Gi1/β1/γ2
23.08Single9WP9S1P9WP9-S1P3-S1P-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.08Single9YDRDADLE9YDR-δ-DADLE-MIPS3983-chim(NtGi1L-Gs-CtGi1)/β1/γ2
23.08Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
23.08Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
22.86Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
22.86Single8FLULA-PTH Analog8FLU-PTH1-LA-PTH Analog-Gs/β1/γ2
22.73Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
22.73Single3REYPubChem 56973REY-A2A-PubChem 5697
22.73Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
22.73Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
22.73Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
22.73Single5IU7Q274563465IU7-A2A-Q27456346-Na
22.73Single5IUBQ274563445IUB-A2A-Q27456344-Na
22.73Single5JTBZM-2413855JTB-A2A-ZM-241385
22.73Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
22.73Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
22.73Single5UVIZM-2413855UVI-A2A-ZM-241385
22.73Single6AQFZM-2413856AQF-A2A-ZM-241385
22.73Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
22.73Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
22.73Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
22.73Single6TPGEMPA6TPG-OX2-EMPA
22.73Single6TPKRetosiban6TPK-OT-Retosiban
22.73Single6V9SGTPL114036V9S-OX1-GTPL11403
22.73Single6VI4JDTic6VI4-κ-JDTic
22.73Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
22.73Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
22.73Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
22.73Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
22.73Single6ZINSR486926ZIN-NTS1-SR48692
22.73Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
22.73Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
22.73Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
22.73Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
22.73Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
22.73Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
22.73Single7T94Acetylcholine7T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
22.73Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
22.73Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
22.73Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
22.73Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.73Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
22.73Single8IHKAcifran8IHK-HCA3-Acifran
22.73Single8JEIPubChem 117155568JEI-HCAR3-PubChem 11715556-Gi1/β1/γ2
22.73Single8K4NPubChem 1687197658K4N-GPR34-PubChem 168719765-Gi1/β1/γ2
22.73Single8K5CAcipimox8K5C-HCA2-Acipimox
22.73Single8K9LDAMGO8K9L-μ-DAMGO-BMS-986122-Gi3/β1/γ1
22.73Single8PM2DMCHA8PM2-TA7-DMCHA-Gs/β1/γ2
22.73Single8RLNLUF58348RLN-A2A-LUF5834
22.73Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
22.73Single8U02Dopamine8U02-D2-Dopamine-Go/β1/γ2
22.73Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
22.73Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
22.73Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
22.73Single8ZPMAMD0708ZPM-CXCR4-AMD070
22.73Single8ZPNAMD31008ZPN-CXCR4-AMD3100
22.73Single9ARXSerotonin9ARX-5-HT2A-Serotonin
22.73Single9AS3LSD9AS3-5-HT2A-LSD
22.73Single9AS4LSD9AS4-5-HT2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single9AS8Psilocin9AS8-5-HT2A-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.73Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
22.73Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single9K1DButyric acid9K1D-FFA2-Butyric acid-Gi1/β1/γ2
22.73Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
22.73Single9KVIBufotenin9KVI-5-HT1A-Bufotenin-PtdIns4P-Gi1/β1/γ2
22.73Single9KXSEP679KXS-C5a1-EP67-Go/β1/γ2
22.73Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
22.73Single9ODJMitragynine Pseudoindoxyl9ODJ-μ-Mitragynine Pseudoindoxyl-GTP; Mg-Gi1/β1/γ2
22.73Single9ODLMitragynine Pseudoindoxyl9ODL-μ-Mitragynine Pseudoindoxyl-GTP; Mg-Gi1/β1/γ2
22.73Consensusa2_offOrthosteric Liganda2a_off
22.73Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA47070-Na 5N2R-A2A-PSB36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-Etrumadenant-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-PubChem 984073-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
22.73Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-CXCL8-Gi1/β1/γ2
22.73Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
22.73Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
22.73Consensusvasop-oxy_offOrthosteric Ligandot_off
22.58Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
22.58Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
22.58Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
22.58Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
22.58Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
22.22Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
22.22Single5VBLAMG3054 5VBL-Apelin-AMG3054
22.22Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
22.22Single7RKNCX3CL17RKN-US28-CX3CL1-Gi1/β1/γ2
22.22Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
22.22Single7V68LY21196207V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
22.22Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
22.22Single7WC4Serotonin7WC4-5-HT2A-Serotonin
22.22Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
22.22Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
22.22Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
22.22Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
22.22Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
22.22Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
22.22Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
22.22Single8PWNTheophylline8PWN-A2A-Theophylline
22.22Single8X5YAstemizole8X5Y-H1-Astemizole
22.22Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
22.22Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
22.22Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
22.22Single9MD1Buspirone9MD1-5-HT1A-Buspirone-PtdIns4P-Gz/β1/γ2
22.22Single9NS9TUG-13759NS9-FFA2-TUG-1375-PubChem 118615810-Gi1/β1/γ2
22.22Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-1-Gs/β1/γ2
22.22Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
21.95Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
21.88Single6FJ3PTH6FJ3-PTH1-PTH
21.88Single6NBFLA-PTH Analog6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2
21.88Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
21.88Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
21.88Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
21.74Single4DAJTiotropium4DAJ-M3-Tiotropium
21.74Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
21.74Single4MQSIperoxo4MQS-M2-Iperoxo
21.74Single4U14Tiotropium4U14-M3-Tiotropium
21.74Single4U16N-methyl-Scopolamine4U16-M3-N-methyl-Scopolamine
21.74Single5IU8Q274563475IU8-A2A-Q27456347-Na
21.74Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
21.74Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
21.74Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
21.74Single5T04Neurotensin-(8-13)5T04-NTS1-Neurotensin-(8-13)
21.74Single5UIGPubChem 1240811965UIG-A2A-PubChem 124081196
21.74Single5YC8N-methyl-Scopolamine5YC8-M2-N-methyl-Scopolamine
21.74Single5ZK8N-methyl-Scopolamine5ZK8-M2-N-methyl-Scopolamine
21.74Single5ZKCN-methyl-Scopolamine5ZKC-M2-N-methyl-Scopolamine
21.74Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
21.74Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
21.74Single6KPFAM120336KPF-CB2-AM12033-Gi1/β1/γ2
21.74Single6TOTLemborexant6TOT-OX1-Lemborexant
21.74Single6Z4VNeurotensin-(9-13)6Z4V-NTS1-Neurotensin-(9-13)
21.74Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
21.74Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
21.74Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
21.74Single7NA8Ibutamoren7NA8-Ghrelin-Ibutamoren-Gi1/β1/γ2
21.74Single7PYRPSB-21157PYR-A2A-PSB-2115
21.74Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
21.74Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
21.74Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
21.74Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
21.74Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
21.74Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
21.74Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
21.74Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
21.74Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
21.74Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.74Single8IC0CXCL88IC0-CXCR1-CXCL8-Gi1/β1/γ2
21.74Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
21.74Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
21.74Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
21.74Single8X63Mepyramine8X63-H1-Mepyramine
21.74Single8X64Desloratadine8X64-H1-Desloratadine
21.74Single8XBGS3E-Lysophosphatidylserine 8XBG-GPR34-S3E-Lysophosphatidylserine
21.74Single8YN8Proxyfan8YN8-H3-Proxyfan-Go/β1/γ2
21.74Single8ZYYNeurotensin-(8-13)8ZYY-NTS1-Neurotensin-(8-13)-SBI-553-Arrestin2
21.74Single9H37PubChem 1756706469H37-A2A-PubChem 175670646-Na
21.74Single9IYAONO-97105319IYA-GPR55-ONO-9710531
21.74Single9JEAAtropine9JEA-M1-Atropine
21.74Single9JGKBalovaptan9JGK-5-HT2B-Balovaptan
21.74Single9KFTfMLFC9KFT-FPR1-ALX-fMLFC-Gi1/β1/γ2
21.74Single9LLAAriadne9LLA-5-HT2A-Ariadne-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.74Single9METGp120; CD49MET-CXCR4-Gp120; CD4
21.74Single9UAZAtropine9UAZ-M1-Atropine
21.74Consensusalpha2_onOrthosteric Ligandalpha2b_on
21.74Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
21.74Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
21.74Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
21.74Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
21.74Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
21.74Consensusblt_onOrthosteric Ligandblt1_on
21.74Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
21.74Consensuscck_offOrthosteric Ligandccka_off
21.74Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
21.74Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-CXCL8-Gi1/β1/γ2
21.74Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
21.74Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
21.74Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
21.74Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
21.74Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
21.74Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
21.74Consensushistamine_offOrthosteric Ligandh1_off
21.74Consensusleukotriene_onOrthosteric Ligandblt_on
21.74Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
21.74Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
21.74Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
21.74Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
21.62Single7Y36PTH7Y36-PTH1-PTH-Gs/β1/γ2
21.62Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
21.62Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
21.43Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
21.43Single8IEBPubChem 1347468948IEB-GPR156; GPR156-PubChem 134746894
21.43Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
21.43Single9M4TSilodosin9M4T-Alpha1A-Silodosin
21.43Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
21.43Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
21.43Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
21.21Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
21.21Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
21.21Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
21.21Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-Lysophosphatidylserine (WJS)-chim(NtGi2-G13)/β1/γ2
21.05Single3RFMCaffeine3RFM-A2A-Caffeine
21.05Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
21.05Single6TQ9SB-4081246TQ9-OX1-SB-408124
21.05Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
21.05Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
21.05Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Single8Z8ALactate8Z8A-HCA1-Lactate-Gi1/β1/γ2
21.05Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
21.05Consensusp2y_offOrthosteric Ligandp2y1_off
21.05Consensussensory_onOrthosteric Ligandopsins_on
20.93Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
20.83Single4NTJAZD12834NTJ-P2Y12-AZD1283
20.83Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
20.83Single5XPRBosentan5XPR-ETB-Bosentan
20.83Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
20.83Single6HLPNetupitant6HLP-NK1-Netupitant
20.83Single6LUQHaloperidol6LUQ-D2-Haloperidol
20.83Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
20.83Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
20.83Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
20.83Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
20.83Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
20.83Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.83Single8IZ4Lysophosphatidylserine (TJR)8IZ4-GPR34-Lysophosphatidylserine (TJR)-Gi1/β1/γ2
20.83Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
20.83Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
20.83Single9ARZ2-bromo-LSD9ARZ-5-HT2A-2-bromo-LSD
20.83Single9AVLCa; Ca; Cyclomethyltryptophan; R-568; PO49AVL-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi3/β2/γ2
20.83Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO49AXF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
20.83Single9KO4CCL219KO4-CCR7-CCL21-Gi1/β1/γ2
20.83Single9KUTJR14a9KUT-C3aB-JR14a-Go/β1/γ2
20.83Single9M8POleic monoethanolamide9M8P-GPR3 ; GPR3-Oleic monoethanolamide-AF64394
20.83Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
20.83Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
20.83Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
20.83Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
20.83Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
20.83Consensusm2_offOrthosteric Ligand5ZKC-M2-N-methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
20.83Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.69Single7PIVAfamelanotide7PIV-MC4-Afamelanotide-Gs/β1/γ2
20.69Single8IEBPubChem 1347468948IEB-GPR156; GPR156-PubChem 134746894
20.69Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
20.69Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
20.69Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
20.59Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
20.59Single6NBHLA-PTH Analog6NBH-PTH1-LA-PTH Analog-Gs/β1/γ2
20.59Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
20.59Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
20.59Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
20.59Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
20.59Single8KGGLysophosphatidylserine (WJS)8KGG-P2Y10-Lysophosphatidylserine (WJS)-chim(NtGi2-G13)/β1/γ2
20.00Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
20.00Single3OE6IT1t3OE6-CXCR4-IT1t
20.00Single4BV0Neurotensin-(7-13)4BV0-NTS1-Neurotensin-(7-13)
20.00Single4DJHJDTic4DJH-κ-JDTic
20.00Single4XNWMRS25004XNW-P2Y1-MRS2500
20.00Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
20.00Single6E59L-7607356E59-NK1-L-760735
20.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
20.00Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
20.00Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
20.00Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
20.00Single7EW4CYM-55417EW4-S1P3-CYM-5541-Gi1/β1/γ2
20.00Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
20.00Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
20.00Single7FEECP559407FEE-CB1-CP55940-ZCZ011
20.00Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
20.00Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
20.00Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
20.00Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
20.00Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
20.00Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
20.00Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
20.00Single7U2LC5-guano7U2L-μ-C5-guano-Gi1/β1/γ2
20.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
20.00Single7WC5Psilocin7WC5-5-HT2A-Psilocin
20.00Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8EA0Iperoxo8EA0-M3-Iperoxo
20.00Single8FMZNeurotensin-(8-13)8FMZ-NTS1-Neurotensin-(8-13)-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8I9LC3a8I9L-C3aB-C3a-Go/β1/γ2
20.00Single8ITFDMCHA8ITF-TAA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
20.00Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
20.00Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
20.00Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
20.00Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
20.00Single8XBIPubChem 1626566368XBI-GPR34-PubChem 162656636
20.00Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.00Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
20.00Single8YFOAc-LA-PTH Analog8YFO-PTH1-Ac-LA-PTH Analog-chim(NtGi1-Gs)/β1/γ2
20.00Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
20.00Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
20.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO49AYF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi1/β1/γ2
20.00Single9CLWTUG-13759CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single9EGOZ85267113509EGO-CB1-Z8526711350-Gi1/β1/γ2
20.00Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
20.00Single9JCLADP9JCL-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
20.00Single9KT93,5-DHBA9KT9-HCA1-3,5-DHBA-Gi1/β1/γ2
20.00Single9LL7DOI9LL7-5-HT2A-DOI-Gi1/β1/γ2
20.00Single9PY3Loperamide9PY3-μ-Loperamide-GDPβS-Gi1/β1/γ2
20.00Single9PY4Loperamide9PY4-μ-Loperamide-GDPβS-Gi1/β1/γ2
20.00Single9RHGC4079RHG-FZD7-C407
20.00Single9YDVMRS29059YDV-P2Y14-MRS2905-Gi1/β1/γ2
20.00Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
20.00Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
20.00Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
20.00Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
20.00Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
20.00Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
20.00Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
20.00Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
20.00Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
20.00Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
20.00Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
20.00Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
20.00Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
20.00Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
20.00Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
19.44Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
19.35Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
19.35Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
19.35Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
19.35Single9BLCCagrilintide (non-acylated)9BLC-CT-Cagrilintide (non-acylated)-Gs/β1/γ2
19.35Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
19.23Single4N4WSANT-14N4W-SMO-SANT-1
19.23Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
19.23Single4PXFOctyl-Beta-D-Glucopyranoside4PXF-Rhodopsin-Octyl-β-D-Glucopyranoside-Arrestin1 Finger Loop
19.23Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
19.23Single4PY02MeSATP4PY0-P2Y12-2MeSATP
19.23Single6KQICP559406KQI-CB1-CP55940-Org27569
19.23Single6ZG4HTL00099366ZG4-M1-HTL0009936
19.23Single7EPENAM5637EPE-mGlu2-NAM563
19.23Single7EW2FTY720-P7EW2-S1P3-FTY720-P-Gi1/β1/γ2
19.23Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
19.23Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.23Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
19.23Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
19.23Single8JWZEtrumadenant8JWZ-A2A-Etrumadenant-Na
19.23Single8WRBLysophosphatidylserine (UBL)8WRB-GPR34-Lysophosphatidylserine (UBL)-Gi1/β1/γ2
19.23Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
19.23Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
19.23Single9EK0Iperoxo9EK0-M5-Iperoxo-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Single9GGGI-BOP9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.23Single9W32SSTR5 antagonist 19W32-SST5-SSTR5 antagonist 1
19.23Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
19.05Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
19.05Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
19.05Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
19.05Single6TP4ACT-4622066TP4-OX1-ACT-462206
19.05Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
19.05Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-PtdIns4P-Gi1/β1/γ2
19.05Single7V68Iperoxo7V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
19.05Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
19.05Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
19.05Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
19.05Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
19.05Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
19.05Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
19.05Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.05Single8ZYUNeurotensin-(8-13)8ZYU-NTS1-Neurotensin-(8-13)-SBI-553-Arrestin2
19.05Single9AS7Psilocin9AS7-5-HT2A-Psilocin
19.05Single9B9YTaranabant9B9Y-CB1-Taranabant
19.05Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.05Single9M88Oleic monoethanolamide9M88-GPR3 ; GPR3-Oleic monoethanolamide-AF64394
19.05Consensusgq_nucleotideOrthosteric Ligandgq_p2y
19.05Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
19.05Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
19.05Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
18.92Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.92Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Exendin-4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Tirzepatide (non-acylated)-Gs/β1/γ2
18.75Single5YQZNNC17025YQZ-Glucagon-NNC1702
18.75Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
18.75Consensuscalcitonin_onOrthosteric Ligandctlike_on
18.75Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-Lysophosphatidylserine (WJS)-chim(NtGi2-G13)/β1/γ2
18.75Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
18.52Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
18.52Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
18.52Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
18.52Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
18.52Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
18.52Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Single8XVJMacitentan8XVJ-ETA-Macitentan
18.52Single8XWFCXCL38XWF-CXCR2-CXCL3
18.52Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
18.52Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
18.52Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
18.42Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
18.42Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.42Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
18.18Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
18.18Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
18.18Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
18.18Single3ODUIT1t3ODU-CXCR4-IT1t
18.18Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
18.18Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
18.18Single4S0VSuvorexant4S0V-OX2-Suvorexant
18.18Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
18.18Single5OLVLUAA470705OLV-A2A-LUAA47070-Na
18.18Single5ZKQABT-4915ZKQ-PAF-ABT-491
18.18Single6B73MP11046B73-κ-MP1104
18.18Single6LFOCXCL86LFO-CXCR2-CXCL8-Gi1/β1/γ2
18.18Single6NBILA-PTH Analog6NBI-PTH1-LA-PTH Analog-Gs/β1/γ2
18.18Single6TPJSuvorexant6TPJ-OX2-Suvorexant
18.18Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
18.18Single7BR3Elagolix7BR3-GnRH1-Elagolix
18.18Single7F8YDevazepide7F8Y-CCKA-Devazepide
18.18Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
18.18Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
18.18Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
18.18Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
18.18Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
18.18Single8DWGML3828DWG-MRGPRX1-BAM8-22-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
18.18Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
18.18Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
18.18Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
18.18Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
18.18Single8Y0HVUF114188Y0H-CXCR3-VUF11418
18.18Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go/β1/γ2
18.18Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
18.18Single9BLWCagrilintide (non-acylated)9BLW-CT (AMY1)-Cagrilintide (non-acylated)-Gs/β1/γ2; RAMP1
18.18Single9H2XPubChem 1756706449H2X-A2A-PubChem 175670644-Na
18.18Single9LKDPL459LKD-OR5V1-PL45
18.18Single9LRBHistamine9LRB-H1-Histamine-Gs/β1/γ2
18.18Single9PEEPF-07054894; OXM29PEE-CCR6-PF-07054894; OXM2
18.18Single9W49U-50488H9W49-κ-U-50488H-Gi1/β1/γ2
18.18Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
18.18Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
18.18Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
18.18Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
18.18Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
18.18Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
18.18Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
18.18Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
18.18Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
18.18Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
18.18Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
18.18Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
17.95Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
17.86Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
17.86Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
17.86Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single8SAILysophosphatidylserine (S12)8SAI-GPR34-Lysophosphatidylserine (S12)-Gi1/β1/γ2
17.86Single9JF4PD1683689JF4-BB1-PD168368
17.86Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single9WSXEndomorphin9WSX-μ-Endomorphin-Arrestin2
17.65Single6P9XCorticoliberin-16P9X-CRF1-Corticoliberin-1-Gs/β1/γ2
17.65Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
17.65Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
17.65Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
17.65Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
17.65Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
17.50Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
17.39Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
17.39Single3RZECidoxepin3RZE-H1-Cidoxepin
17.39Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
17.39Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
17.39Single6TP3Nemorexant6TP3-OX1-Nemorexant
17.39Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
17.39Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
17.39Single7UTZDPPC7UTZ-TSH-TSH-DPPC-Gs/β1/γ2
17.39Single7VODCariprazine7VOD-5-HT2A-Cariprazine
17.39Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
17.39Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
17.39Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
17.39Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
17.39Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
17.39Single8ZBWQuin-C18ZBW-FPR2-ALX-Quin-C1-Gi2/β1/γ2
17.39Single9ASBCa; Ca; Cyclomethyltryptophan; R-568; PO49ASB-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single9BA0MRI-18919BA0-CB1-MRI-1891
17.39Single9IXXLTD49IXX-CysLT2-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single9JFUNE52-QQ579JFU-GPR4-NE52-QQ57
17.39Single9JKYAcifran9JKY-HCA2-Acifran-Gi1/β1/γ2
17.39Single9LKBPL459LKB-OR5V1-PL45-chim(NtGi1-Gs)/β1
17.39Single9LRDHistamine9LRD-H1-Histamine-Gi1/β1/γ2
17.39Single9M2FNeuropeptide-FF9M2F-NPFF1-Neuropeptide-FF-Gi1/β1/γ2
17.39Single9PY2Loperamide9PY2-μ-Loperamide-GDPβS-Gi1/β1/γ2
17.39Single9U80Conivaptan9U80-V2-Conivaptan
17.39Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
17.39Consensusgrh_offOrthosteric Ligandgnrh1_off
17.39Consensusopsins_offOrthosteric Ligandrhodopsin_off
17.39Consensussensory_offOrthosteric Ligandopsins_off
17.24Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
17.24Single7QA8Antagonist Peptide7QA8-STE2; STE2-Antagonist Peptide
17.24Single7QA8Antagonist Peptide7QA8-STE2; STE2-Antagonist Peptide
17.24Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
17.24Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
17.24Single8IEIPubChem 1347468948IEI-GPR156; GPR156-PubChem 134746894
17.24Single8IEIPubChem 1347468948IEI-GPR156; GPR156-PubChem 134746894
17.24Single8IEPPubChem 1347468948IEP-GPR156; GPR156-PubChem 134746894
17.24Single8IEPPubChem 1347468948IEP-GPR156; GPR156-PubChem 134746894
17.24Single8KIGSHU91198KIG-MC3-SHU9119-Ca
17.24Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
17.24Single9UYLChemerin-99UYL-CML2-Chemerin-9-Arrestin2
17.24Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
17.24Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
17.14Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
17.14Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
17.14Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
17.14Consensuspth1_onOrthosteric Ligand6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-PTH-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
16.67Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
16.67Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
16.67Single4QIMANTA XV4QIM-SMO-ANTA XV
16.67Single5DHHSB-6121115DHH-NOP-SB-612111
16.67Single5DSGTiotropium5DSG-M4-Tiotropium
16.67Single5MZPCaffeine5MZP-A2A-Caffeine-Na
16.67Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
16.67Single5TGZAM65385TGZ-CB1-AM6538
16.67Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
16.67Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
16.67Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
16.67Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
16.67Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
16.67Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
16.67Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
16.67Single7VIFFTY720-P7VIF-S1P1-FTY720-P-Gi1/β1/γ2
16.67Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
16.67Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
16.67Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
16.67Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
16.67Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
16.67Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single9AVGCa; Ca; Cyclomethyltryptophan; R-568; PO49AVG-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs)/β1/γ2
16.67Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
16.67Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
16.67Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
16.22Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
16.22Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Exendin-4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Tirzepatide (non-acylated)-Gs/β1/γ2
16.13Single9B5YLA-PTH Analog9B5Y-PTH1-LA-PTH Analog-chim(NtGi1-Gq)/β1/γ2
16.00Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
16.00Single5CGCHTL142425CGC-mGlu5-HTL14242
16.00Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
16.00Single7C4SS1P7C4S-S1P3-S1P
16.00Single7SINNPS-21437SIN-CaS; CaS-NPS-2143
16.00Single7SINNPS-21437SIN-CaS; CaS-NPS-2143
16.00Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
16.00Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
16.00Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
16.00Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutamate-VU0155041-Gi3/β1/γ2
16.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO49AYF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi1/β1/γ2
16.00Single9B9ZMRI-18679B9Z-CB1-MRI-1867
16.00Single9JKSPubChem 442501769JKS-HCA3-PubChem 44250176-Gi1/β1/γ2
16.00Single9KT6Acifran9KT6-HCA3-Acifran-Gi1/β1/γ2
16.00Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
16.00Consensusblt_offOrthosteric Ligandblt1_off
16.00Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
15.79Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
15.79Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
15.79Single7XKEDehydroepiandrosterone7XKE-ADGRG2-Dehydroepiandrosterone-chim(NtGi1-Gs)/β1/γ2
15.79Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-LA-PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-PTH-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
15.62Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
15.62Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
15.62Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
15.62Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
15.38Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
15.38Single7R0CAVP7R0C-V2-AVP-Arrestin2
15.38Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
15.38Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
15.38Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
15.38Single9AS9RS130-1809AS9-5-HT2A-RS130-180
15.38Single9ASARS130-1809ASA-5-HT2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single9UCPIperoxo9UCP-M1-Iperoxo-G11(CT)
15.15Single7QBIAlpha-factor mating pheromone7QBI-STE2; STE2-α-factor mating pheromone
15.15Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
15.15Single7XV3Lysophosphatidylserine (WJS)7XV3-GPR174-Lysophosphatidylserine (WJS)-chim(NtGi1-Gs)/β1/γ2
15.15Single8YG4LA-PTH Analog8YG4-PTH1-LA-PTH Analog-chim(NtGi1-Gs)/β1/γ2
15.00Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
15.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS; CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
15.00Single9L0HJR14a9L0H-C3aB-JR14a-Go/β1/γ2
15.00Single9M42A1L8O9M42-GPR139-A1L8O-chim(Gs-CtGq)/β1/γ2
14.81Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
14.81Single8DWCBAM8-228DWC-MRGPRX1-BAM8-22-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.81Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
14.81Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single8XJNCloprosetnol8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
14.81Single9YDUUDP-Glucose9YDU-P2Y14-UDP-Glucose-Gi1/β1/γ2
14.81Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM-5541-Gi1/β1/γ2 7EW2-S1P3-FTY720-P-Gi1/β1/γ2
14.71Single7QBIAlpha-factor mating pheromone7QBI-STE2; STE2-α-factor mating pheromone
14.71Single9BLBCagrilintide (non-acylated)9BLB-CT-Cagrilintide (non-acylated)-Gs/β1/γ2
14.71Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
14.71Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
14.71Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
14.29Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
14.29Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
14.29Single3UZAGTPL92363UZA-A2A-GTPL9236
14.29Single5CGDHTL142425CGD-mGlu5-HTL14242
14.29Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
14.29Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
14.29Single6K1QIRL25006K1Q-ETB-IRL2500
14.29Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
14.29Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
14.29Single7AD3Alpha-factor mating pheromone7AD3-STE2; STE2-α-factor mating pheromone-Gi1/STE4/γ2
14.29Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS; CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
14.29Single7QBCAlpha-factor mating pheromone7QBC-STE2; STE2-α-factor mating pheromone
14.29Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
14.29Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
14.29Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
14.29Single8IU2All-trans-Retinal8IU2-Opsin1LW-All-trans-Retinal-Gi1/β1/γ2
14.29Single8JEFPubChem 113671668JEF-HCA3-PubChem 11367166-Gi1/β1/γ2
14.29Single8XJOU466198XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9GG5U466199GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single9IJRC179IJR-GPR52-C17-Arrestin2
14.29Single9JG1Adriforant9JG1-H4-Adriforant
14.29Single9M1HPGE29M1H-EP1-PGE2-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
14.29Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-All-trans-Retinal-Gi1/β1/γ2
14.29Consensusgi_sensoryOrthosteric Ligandgi_opsins
14.29Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
14.29Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
14.29Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-All-trans-Retinal-Gi1/β1/γ2
14.29Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-All-trans-Retinal-Gi1/β1/γ2
14.29Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
14.29Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
14.29Consensustp_onOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Consensustp_on_gpOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
13.95Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
13.89Single7QBCAlpha-factor mating pheromone7QBC-STE2; STE2-α-factor mating pheromone
13.89Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
13.89Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
13.89Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
13.89Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
13.79Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.79Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
13.79Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
13.79Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
13.64Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
13.64Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
13.64Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
13.64Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
13.64Single4O9RCyclopamine4O9R-SMO-Cyclopamine
13.64Single5L7IVismodegib5L7I-SMO-Vismodegib
13.64Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
13.64Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
13.64Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
13.64Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
13.64Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS; CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
13.64Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS; CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
13.64Single7UL2SR486927UL2-NTS1-SR48692-Na
13.64Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
13.64Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
13.64Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
13.64Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
13.64Single9EPRAll-trans-Retinal9EPR-Rhodopsin-All-trans-Retinal-Gi1/β1/γ2
13.64Single9IZDCHBA9IZD-HCA1-CHBA-Gi1/β1/γ2
13.64Single9JLCAVE 09919JLC-MAS1-AVE 0991-Gi1/β1/γ2
13.64Single9LMPNE52-QQ579LMP-GPR4-NE52-QQ57
13.64Consensusneurotensin_offOrthosteric Ligandnts1_off
13.64Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
13.51Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
13.51Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
13.33Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
13.33Single8DWGBAM8-228DWG-MRGPRX1-BAM8-22-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
13.33Single8IZBLysophosphatidylserine (UBL)8IZB-GPR174-Lysophosphatidylserine (UBL)-Gs/β1/γ2
13.33Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
13.33Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
13.16Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
13.16Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
13.04Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
13.04Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
13.04Single4QINSAG1.54QIN-SMO-SAG1.5
13.04Single5U09Taranabant5U09-CB1-Taranabant
13.04Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
13.04Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
13.04Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
13.04Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS; CaS-Ca; Ca; Tryptophan; NPS-2143
13.04Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS; CaS-Ca; Ca; Tryptophan; NPS-2143
13.04Single7M3FCa; Ca; Tryptophan; Cinacalcet7M3F-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet
13.04Single7M3FCa; Ca; Tryptophan; Cinacalcet7M3F-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet
13.04Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
13.04Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
13.04Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
13.04Single8T3VDoconexent8T3V-FFA1-Doconexent-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
13.04Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca
13.04Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
13.04Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS; CaS-Ca-Ca; Tryptophan; '6218; PO4
13.04Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS; CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
13.04Single9K6LSalicin9K6L-TAS2R16-Salicin-Gi2/β1/γ2
13.04Single9KPESalicin9KPE-TAS2R16-Salicin-Gi1/β1/γ2
13.04Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
13.04Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
13.04Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
12.90Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
12.50Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
12.50Single6IQLL7458706IQL-D4-L745870
12.50Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
12.50Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
12.50Single6ZG9GSK10347026ZG9-M1-GSK1034702
12.50Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS; CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
12.50Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
12.50Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
12.50Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
12.50Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.50Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca
12.50Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8Y01All-trans-Retinal8Y01-Opsin1MW-All-trans-Retinal-Gi1/β1/γ2
12.50Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single9ASBCa; Ca; Cyclomethyltryptophan; R-568; PO49ASB-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single9AVGCa; Ca; Cyclomethyltryptophan; R-568; PO49AVG-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs)/β1/γ2
12.50Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO49AXF-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single9KPDSalicin9KPD-TAS2R16-Salicin-chim(Gs-CtGt3)/β1/γ2
12.50Single9W33S5A19W33-SST5-S5A1
12.50Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
12.50Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
12.12Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
12.00Single5DHGC-355DHG-NOP-C-35
12.00Single6GPSMK08126GPS-CCR2-MK0812
12.00Single6IIVDaltroban6IIV-TXA2-Daltroban
12.00Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
12.00Single7M3JNPS-2143; PO47M3J-CaS; CaS-NPS-2143; PO4
12.00Single8GCML-9026888GCM-EP4-L-902688-Gi1/β1/γ2
12.00Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
12.00Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
12.00Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
12.00Single9IMATalquetamab9IMA-GPRC5D; GPRC5D-Talquetamab
12.00Single9JQZGrapiprant 9JQZ-EP4-Grapiprant
12.00Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
11.76Single7TYHCalcitonin7TYH-CT (AMY2)-Calcitonin-Gs/β1/γ2; RAMP2
11.54Single4JKVTaladegib4JKV-SMO-Taladegib
11.54Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
11.54Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
11.54Single6GPXMK08126GPX-CCR2-MK0812
11.54Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
11.54Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
11.54Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS; CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
11.54Single7M3JNPS-2143; PO47M3J-CaS; CaS-NPS-2143; PO4
11.54Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
11.54Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
11.54Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
11.54Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
11.54Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
11.54Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
11.54Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
11.54Single8ZVZBW245C8ZVZ-DP1-BW245C-Gs/β1/γ2
11.54Single9EKHONO-30302979EKH-DP1-ONO-3030297
11.54Single9KPFSalicin9KPF-TAS2R16-Salicin-Gi1/β1/γ2
11.54Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-Dehydroepiandrosterone-Gs/β1/γ2
11.54Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-Dehydroepiandrosterone-Gs/β1/γ2
11.54Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
11.54Consensusep_offOrthosteric Ligandep4_off
11.54Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
11.43Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
11.11Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
11.11Single5V56TC1145V56-SMO-TC114
11.11Single5V57TC1145V57-SMO-TC114
11.11Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
11.11Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8X0FVU298X0F-mGlu5; mGlu5-Quisqualate-VU29
11.11Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
11.11Single8ZW0PGD28ZW0-DP1-PGD2-Gs/β1/γ2
11.11Single9E9SPGD29E9S-DP1-PGD2-Gs/β1/γ1
11.11Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
10.81Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
10.71Single6AK3PGE26AK3-EP3-PGE2
10.71Single6IIURamatroban6IIU-TXA2-Ramatroban
10.71Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
10.71Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
10.71Single9AU0BW245C9AU0-DP1-BW245C-Gs/β1/γ2
10.71Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
10.71Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
10.53Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
10.53Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
10.34Single7D7MPGE27D7M-EP4-PGE2-Gs/β1/γ1
10.00Single7XKDDehydroepiandrosterone7XKD-ADGRG2-Dehydroepiandrosterone-Gs/β1/γ2
10.00Single9JIDNiacin9JID-HCA3-Niacin-Gi1/β1/γ2
9.68Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
9.68Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
9.52Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
9.52Single3OE8IT1t3OE8-CXCR4-IT1t
9.52Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
9.52Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
9.52Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
9.52Single8Y02All-trans-Retinal8Y02-OPN1SW-All-trans-Retinal-Gi1/β1/γ2
9.52Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS; CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
9.38Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
9.09Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
9.09Single8JPSCCL78JPS-ACKR1-CCL7
9.09Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
9.09Single9JKT(2R)-2-hydroxy-3-phenylpropanoic acid9JKT-HCA3-(2R)-2-hydroxy-3-phenylpropanoic acid-Gi1/β1/γ2
8.82Single6NIYCalcitonin-16NIY-CT-Calcitonin-1-Gs/β1/γ2
8.82Single7AD3Alpha-factor mating pheromone7AD3-STE2; STE2-α-factor mating pheromone-Gi1/STE4/γ2
8.70Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
8.70Single6LI0C176LI0-GPR52-C17
8.70Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
8.70Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
8.70Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS; CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.70Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
8.70Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS; CaS-Ca-Ca; Tryptophan; '6218; PO4
8.70Single9YDAAll-trans-Retinal9YDA-Opsin1MW-All-trans-Retinal-chim(NtGi1L-Gs-CtGt)/β1/γ2
8.70Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg4_on
8.70Consensusadgrg_on_gpOrthosteric Ligandadgrg2_on_gp adgrg4_on_gp
8.33Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
8.33Single7SILCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO47SIL-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4
8.33Single7SILCa; Ca; Ca; Cyclomethyltryptophan; R-568; PO47SIL-CaS; CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; R-568; PO4
8.33Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
8.33Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
8.33Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
8.33Single9AVLCa; Ca; Cyclomethyltryptophan; R-568; PO49AVL-CaS; CaS-Ca-Ca; Ca; Cyclomethyltryptophan; R-568; PO4-Gi3/β2/γ2
8.00Single6FFIMPEP6FFI-mGlu5-MPEP
8.00Single8K2WAMG4878K2W-CXCR3-AMG487
8.00Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
8.00Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
7.89Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
7.69Single6FFHFenobam6FFH-mGlu5-Fenobam
7.69Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
7.69Single7F83PF-051904577F83-Ghrelin-PF-05190457
7.69Single7YXAONO-54306087YXA-S1P5-ONO-5430608
7.69Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
7.69Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
7.41Single5T1ABMS-6815T1A-CCR2-BMS-681-PubChem 12093170
7.41Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
7.41Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
7.41Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41Single9EE5ONO-25502899EE5-DP1-ONO-2550289
7.41Single9HC04YI9HC0-mGlu5-4YI
7.14Single7P2L4YI7P2L-mGlu5-4YI
7.14Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
7.14Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
7.14Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
7.14Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
6.90Single5X33BIIL2605X33-BLT1-BIIL260
6.90Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
6.90Single9BJKPubChem 1716420669BJK-μ-Naloxone-PubChem 171642066
6.67Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
6.67Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
6.45Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
6.25Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
5.56Consensusclass-b2_onOrthosteric Ligandadgrg_on adgrf_on adgrl_on adgre_on adgrd_on
5.56Consensusclass-b2_on_gpOrthosteric Ligandadgrg_on_gp adgrf_on_gp adgrl_on_gp adgre_on_gp adgrd_on_gp
5.26Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
5.26Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
4.76Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
4.76Single9JKVPubChem 27366909JKV-HCA3-PubChem 2736690-Gi1/β1/γ2
4.55Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
4.35Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
4.35Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
4.35Single8J6QPubChem 251012238J6Q-HCA2-β-Hydroxybutyrate-PubChem 25101223-Gi1/β1/γ2
4.35Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
4.17Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
4.17Single7XKFDehydroepiandrosterone7XKF-ADGRG2-Dehydroepiandrosterone-Gs/β1/γ2
4.17Single8J6PPubChem 251012238J6P-HCA2-Niacin-PubChem 25101223-Gi1/β1/γ2
4.17Single8JHYPubChem 251012238JHY-HCA2-PubChem 25101223-Gi1/β1/γ2
4.17Single8JIIPubChem 251012238JII-HCA2-Niacin-PubChem 25101223-Gi1/β1/γ2
4.17Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS; CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
4.17Single9MBCAZ122160529MBC-mGlu8; mGlu8-DCPG-AZ12216052
4.00Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
4.00Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
4.00Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.00Single8G94CD698G94-S1P1-CD69-Gi1/β1/γ2
4.00Single8Y71BMS9861878Y71-δ-A1D6F-BMS986187-Gi1/β1/γ2
4.00Single9L60MPAM-159L60-κ-Dynorphin-MPAM-15-Gi1/β1/γ2
3.85Single7VV6C48/807VV6-MRGPRX2-C48/80
3.85Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single8IYXYL-3658IYX-GPR34-YL-365
3.70Single8Y73MPAM-158Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
3.70Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
3.70Single9JROPF-044189489JRO-EP2-PF-04418948
3.70Single9YDQMIPS36149YDQ-δ-DADLE-MIPS3614-chim(NtGi1L-Gs-CtGi1)/β1/γ2
3.70Single9YDRMIPS39839YDR-δ-DADLE-MIPS3983-chim(NtGi1L-Gs-CtGi1)/β1/γ2
3.57Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
3.57Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
3.57Single9JRTTG6-1299JRT-EP2-TG6-129
3.45Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1

Consensus Members
Id Members
7YKD 7YKD-CML1-Chemerin-9-Gi1/β1/γ2
Net Summary
Imin 3.71
Number of Linked Nodes 835
Number of Links 981
Number of Hubs 141
Number of Links mediated by Hubs 539
Number of Communities 20
Number of Nodes involved in Communities 201
Number of Links involved in Communities 283
Path Summary
Number Of Nodes in MetaPath 107
Number Of Links MetaPath 106
Number of Shortest Paths 1980532
Length Of Smallest Path 3
Average Path Length 43.1223
Length of Longest Path 77
Minimum Path Strength 1.23
Average Path Strength 7.38781
Maximum Path Strength 23.84
Minimum Path Correlation 0.7
Average Path Correlation 0.982967
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.85185
Average % Of Corr. Nodes 34.9805
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 46.5587
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
gi_proteingi_chemokine
gi_chemerin



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