Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1b.1x16 2.51187404
2b.lhb1x3 2.9765502
3b.l1x3 8.52667679
4b.b2x1 8.358568
5b.b2x3 3.8775576
6b.b2x5 7.456577
7b.b3x3 4.094588
8b.l3x2 4.5705579
9b.b4x3 4.8225487
10b.b4x6 9.73083679
11b.b5x2 5.82062407
12b.b5x3 6.63667679
13b.b5x5 5.44063405
14b.b5x7 6.2975407
15b.l5x1 4.6415588
16b.l5x5 7.02036709
17b.b6x5 4.20208686
18b.l6x5 5.934174
19b.b7x1 5.9445174
20b.b7x2 3.82125488
21b.l7x4 4.175429
22b.b8x3 4.31812406
23b.b8x4 5.45875686
24b.b9x4 6.87375409
25b.l9x3 7.4035529
26b.l9x6 5.2325928
27b.b10x5 5.38167609
28b.l11x2 8.70375429
29b.b12x3 3.45937448
30b.b12x6 7.7375728
31b.b13x7 7.698547
32b.l13x3 8.258549
33b.l13x6 5.406529
34b.l13x7 4.1535549
35b.b14x3 4.87063445
36b.b14x5 3.46563445
37b.b15x1 5.88214749
38b.b15x2 8.1275456
39b.b15x3 4.52875449
40b.l15x1 5.60938427
41b.l15x2 5.6725549
42b.b16x4 8.2805546
43b.b16x5 5.52875405
44b.b16x6 8.8515548
45b.b17x5 7.69312457
46b.b17x7 8.46313458
47b.l17x3 8.15167659
48b.l17x6 7.60375429
49b.b18x3 5.42562458
50b.b18x5 6.06125455
51b.l18x1 5.980948126
52b.l18x2 5.561884127
53b.b19x2 7.34464756
54b.b19x4 5.375458
55b.l19x2 6.01559
56b.b20x4 10.1395558
57b.b20x6 7.6995556
58b.b21x1 8.97688457
59b.b21x2 3.135506
60b.b21x5 6.125404
61b.b21x7 6.9845505
62b.b22x5 5.77155127
63b.l22x5 7.4585219
64b.b23x1 4.17875405
65b.b23x6 7.2956187
66b.l23x1 8.23937466
67b.b24x4 7.403754186
68b.b24x6 6.321884188
69b.l24x3 3.76938405
70b.l25x3 8.707599
71b.l25x6 11.5587468
72b.l26x5 5.5375405
73b.l27x1 10.5471769
74b.l27x2 7.10125499
75b.b28x3 4.81687407
76b.b28x4 7.61625496
77b.b28x6 8.25417699
78g.h1x11 2.35063409
79g.h2x11 9.440634126
80g.ctx3 8.05937409
81g.ctx6 5.28938406
82g.ctx9 3.62254256
83g.ctx14 5.21875409
84g.ctx16 5.20955228
85G.HN.11 2.04187402
86G.HN.37 2.44938403
87G.S1.02 5.04655105
88G.S1.05 6.2025429
89G.S1.06 4.28855268
90G.H1.01 5.330634269
91G.S2.05 5.3245163
92G.S2.08 7.83754105
93G.S3.01 5.016874104
94G.S3.03 8.536884107
95G.S3.04 8.618754166
96G.S3.06 9.018754165
97G.S3.08 4.76312429
98G.s3h2.03 4.5345529
99G.H2.06 6.00214729
100G.H2.07 5.44458629
101G.h2s4.01 7.0485529
102G.S4.04 6.55313409
103G.s4h3.01 5.72812437
104G.s4h3.04 5.3275738
105G.s4h3.08 2.245408
106G.H3.01 5.55125409
107G.H3.09 6.78625639
108G.H3.17 7.26665
109G.H3.18 5.668569
110G.S5.05 4.341256199
111G.S5.06 6.24187438
112G.s5hg.01 4.06625439
113G.HG.04 4.8445539
114G.HG.15 5.22875407
115G.hgh4.02 5.977207
116G.hgh4.05 9.14125407
117G.H4.03 6.73813404
118G.H4.10 9.964206
119G.H4.12 5.27313435
120G.H4.15 6.7725438
121G.S6.02 5.361676137
122G.S6.05 4.41563434
123G.s6h5.01 5.164374199
124G.s6h5.02 2.12375407
125G.H5.03 5.6054198
126G.H5.08 6.538754108
127G.H5.13 6.034374138
128G.H5.14 4.078754137
1291x54 4.49687408
130I1x50 7.834384289
1312x40 4.76255289
1322x42 4.2075508
1332x46 5.187519
1342x50 8.20375419
1352x57 4.894519
1362x60 8.38938408
1372x66 2.9615115
138E1x50 8.027086119
139E1x51 3.4035115
1403x28 6.1045507
1413x32 6.5305519
1423x33 7.9965519
1433x37 5.90812419
1443x49 6.93955159
1453x50 6.37755149
1463x51 8.54409
147I2x53 9.21555159
148I2x57 9.7575159
1494x50 4.75688419
1504x57 9.6195518
1514x64 7.57254307
152E2.R178 5.66687405
153E2.V180 5.89437405
154E2x52 5.687507
155E2.Q188 5.97625408
156E2.F189 6.65754308
1575x36 3.67125407
1585x41 3.568124317
1595x47 8.35542619
1605x48 4.50875618
1615x51 3.65312418
1625x58 5.73208609
1636x29 5.3925507
1646x30 4.1525409
1656x44 4.79375619
1666x48 6.04056919
1676x51 6.65792619
1686x52 7.4025419
1696x59 4.366884317
170E3.I430 4.2575516
1717x34 5.27562416
1727x38 7.82833617
1737x39 4.53687419
1747x42 7.1535519
1757x45 8.33875419
1767x53 5.281676149
1778x50 7.351254289
1788x53 2.91812409
1798x54 4.62687409
180Lig 6.258211410
1811x31 1.0075400
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.1x12 b.1x9 19.99982.025NoNo064
2b.1x5 b.1x9 13.30193.1975NoNo034
3b.1x12 g.h1x11 13.37263.1725NoYes069
4b.1x15 b.1x19 36.21342.8175NoNo076
5b.1x12 b.1x15 34.30312.41NoNo067
6b.1x19 b.b21x1 44.80598.9325NoYes067
7b.b17x7 b.b21x1 46.68324.7775YesYes587
8b.b17x7 b.b20x6 50.47439.645YesYes586
9b.b19x4 b.b20x6 20.64667.78YesYes586
10b.b19x4 b.l17x3 30.50316.5YesYes589
11b.l17x3 b.l19x2 53.34665.355YesYes599
12b.l17x5 b.l19x2 76.49955.5175NoYes069
13b.l17x5 b.l19x1 76.80732.5725NoNo069
14b.l17x6 b.l19x1 38.82545.6525YesNo099
15G.H2.06 b.l17x6 38.437110.37YesYes299
16G.H2.06 b.l9x6 77.4393.2825YesYes298
17b.l5x5 b.l7x2 12.30354.5575YesNo099
18b.l3x1 b.l5x5 16.8865.475NoYes099
19b.b2x1 b.l3x1 16.616212.965YesNo689
20b.b2x1 b.l27x1 16.19549.6475YesYes689
21b.l25x6 b.l27x1 10.134617.74YesYes689
22b.l23x1 b.l25x6 10.052320.5475YesYes668
23b.b20x4 b.b20x6 41.28273.475YesYes586
24b.b20x4 b.l17x3 21.593214.67YesYes589
25b.b20x2 b.b20x4 21.59237.115NoYes068
26b.b20x2 b.l19x2 22.22039.7575NoYes069
27b.b18x1 b.l19x1 38.289610.095NoNo099
28G.H2.06 b.b18x1 38.43735.9475YesNo099
29G.H2.07 b.l9x6 87.29554.3425YesYes298
30G.H2.07 G.h2s4.01 44.21064.26YesYes299
31b.b10x1 b.l9x6 16.55763.1775NoYes098
32b.b10x1 b.b11x5 16.4014.075NoNo096
33b.b11x5 b.b14x3 11.83055.6325NoYes065
34b.b26x1 b.l27x1 13.6014.94NoYes099
35b.b26x1 b.b26x2 13.4653.01NoNo097
36b.b26x2 b.b2x3 13.33354.05NoYes076
37b.b22x1 b.l25x6 13.92552.9125NoYes688
38b.b22x1 b.b22x2 13.87493.6NoNo088
39b.b22x2 b.b26x3 13.73866.0075NoNo086
40G.H2.07 G.S3.08 38.12777.9725YesYes299
41b.b18x5 b.b19x2 10.20622.945YesYes556
42b.1x11 g.h1x11 10.50092.77NoYes089
43G.S5.05 G.s6h5.01 89.56873.8925YesYes1999
44G.S5.07 G.s6h5.01 91.53114.3875NoYes099
45G.S5.07 G.s5hg.01 92.15816.2975NoYes099
46G.s4h3.02 G.s5hg.01 95.03523.06NoYes399
47G.HG.07 G.s4h3.02 95.46835.355NoNo399
48G.HG.07 G.s4h3.04 95.65778.0625NoYes398
49G.HG.04 G.s4h3.04 32.55254.6425YesYes398
50G.HG.04 G.s4h3.01 33.46547.0025YesYes397
51G.S5.06 G.s4h3.01 33.42428.9975YesYes387
52G.S5.04 G.S5.06 33.58855.535NoYes398
53G.H3.09 G.S5.04 33.64114.8725YesNo399
54G.H3.09 G.S4.04 99.952315.8075YesYes099
55G.H3.12 G.S4.04 1002.825NoYes089
56G.H3.12 G.S1.07 77.89824.28NoNo089
57G.S1.05 G.S1.07 77.88174.845YesNo099
58G.S1.05 G.S3.08 38.18792.98YesYes299
59G.HG.15 G.s4h3.04 32.36493.81YesYes078
60G.HG.15 G.hgh4.02 32.6475.04YesYes077
61G.H3.06 G.hgh4.02 65.51074.8NoYes067
62G.H3.06 G.H4.15 65.6197.405NoYes068
63G.H3.09 G.H4.15 65.79987.505YesYes398
64G.hgh4.01 G.s4h3.04 32.21673.695NoYes068
65G.hgh4.01 G.hgh4.02 32.27249.875NoYes067
66G.S1.05 G.h2s4.01 39.640514.005YesYes299
67G.H5.10 G.S6.02 81.53155.0025NoYes067
68G.H5.10 G.S5.03 81.74293.25NoNo068
69G.S5.03 G.S5.05 82.16783.14NoYes089
70G.H3.12 G.H3.18 22.82263.1375NoYes089
71G.H3.15 G.H3.18 22.43663.9225NoYes689
726x29 G.H5.13 79.50997.445YesYes078
73G.H5.13 G.S6.02 79.75968.6225YesYes1387
743x50 G.H5.25 73.26828.5YesNo097
75G.H5.20 G.H5.25 73.48463.1125NoNo097
766x29 G.H5.20 76.29032.4275YesNo079
773x43 7x53 47.21956.74NoYes099
783x50 7x53 56.46857.2YesYes1499
796x48 Lig 29.79078.9375YesYes190
806x44 6x48 31.84957.515YesYes199
813x43 6x44 39.08873.35NoYes099
82G.H3.17 b.l25x6 13.97545.035YesYes658
83b.b19x2 b.b20x6 10.510312.0575YesYes566
84G.H3.15 G.H3.17 22.23547.18NoYes685
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x563x329.941NoYes9921
2x567x426.99751NoYes9922
2x603x285.3050YesYes8722
2x607x3817.62250YesYes8721
3x327x382.8751YesYes9711
3x327x4210.9151YesYes9912
3x32Lig4.7351YesYes9010
3x334x5713.86251YesYes9811
3x33E2x525.65251YesYes9712
3x336x516.45251YesYes9911
3x337x385.461YesYes9711
3x33Lig8.5551YesYes9010
3x366x483.39751NoYes8911
3x36Lig6.82751NoYes8010
3x373x415.60751YesNo9812
3x374x535.58751YesNo9912
3x374x578.4751YesYes9811
3x37Lig3.96251YesYes9010
3x406x444.58751NoYes9922
3x406x484.291NoYes9921
4x564x575.97750NoYes8821
4x575x438.1851YesNo8912
4x57Lig11.59751YesYes8010
E2.V180E2x5110.48750YesNo0421
5x461Lig2.98750NoYes9010
5x476x444.8251YesYes9922
5x476x486.0151YesYes9921
5x476x5217.21751YesYes9922
6x446x487.5151YesYes9921
6x447x454.22751YesYes9922
6x476x483.3351NoYes9921
6x477x459.871NoYes9922
6x486x523.67251YesYes9912
6x487x418.16251YesNo9911
6x487x459.041YesYes9912
6x48Lig8.93751YesYes9010
6x516x525.23251YesYes9912
6x516x556.6251YesNo9812
6x517x386.4551YesYes9711
6x517x414.031YesNo9911
6x51Lig11.15251YesYes9010
6x54E3.I4304.00751NoYes7022
6x547x342.911NoYes7621
6x587x344.80250NoYes5621
7x34E3.I4308.5151YesYes6012
7x387x426.71YesYes7912
7x38Lig7.85751YesYes7010
7x41Lig4.87251NoYes9010
3x283x324.18750YesYes7921
E2x51Lig7.9250NoYes4010
7x34Lig4.8751YesYes6010
7x31Lig2.55750NoYes3010
E3.S428Lig0.77250NoYes0010

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
86.67Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
66.67Single4MQSIperoxo4MQS-M2-Iperoxo
66.67Single4U14Tiotropium4U14-M3-Tiotropium
66.67Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
66.67Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
66.67Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
62.50Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
62.50Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
62.50Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
60.00Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
60.00Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
60.00Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
60.00Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
58.82Single4U15Tiotropium4U15-M3-Tiotropium
58.82Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
58.82Single6OL9Tiotropium6OL9-M5-Tiotropium
58.82Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
58.82Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
58.82Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
58.82Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
56.25Single4DAJTiotropium4DAJ-M3-Tiotropium
56.25Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
56.25Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
56.25Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
56.25Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
56.25Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
55.56Single5CXVTiotropium5CXV-M1-Tiotropium
55.56Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
55.56Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
55.56Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
55.56Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
53.33Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
53.33Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
53.33Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
53.33Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
53.33Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
52.94Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
52.94Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
52.94Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
52.94Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
52.94Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
52.94Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
52.94Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
52.63Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
52.63Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
52.63Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
50.00Single3RZECidoxepin3RZE-H1-Cidoxepin
50.00Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
50.00Single5WF5UK-4320975WF5-A2A-UK-432097
50.00Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
50.00Single7UL3Famotidine7UL3-H2-Famotidine
50.00Single8EA0Iperoxo8EA0-M3-Iperoxo
50.00Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
50.00Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
50.00Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
50.00Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
50.00Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
47.62Single4IARErgotamine4IAR-5-HT1B-Ergotamine
47.62Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
47.62Single8WDTphotoNECA8WDT-A2A-photoNECA
47.62Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
47.37Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
47.37Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
47.37Single6ZG4HTL00099366ZG4-M1-HTL0009936
47.37Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
47.37Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
47.06Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
47.06Single5DSGTiotropium5DSG-M4-Tiotropium
47.06Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
47.06Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
47.06Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
47.06Single8X63Mepyramine8X63-H1-Mepyramine
47.06Consensusalpha2_onOrthosteric Ligandalpha2b_on
47.06Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
47.06Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
47.06Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
47.06Consensushistamine_offOrthosteric Ligandh1_off
47.06Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
46.67Single7SRQLSD7SRQ-5-HT2B-LSD
46.67Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
46.67Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
46.67Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
46.67Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
46.67Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
46.67Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
45.45Single3QAKUK-4320973QAK-A2A-UK-432097
45.45Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
45.00Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
45.00Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
45.00Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
45.00Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
45.00Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
45.00Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
44.44Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
44.44Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
44.44Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
44.44Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
44.44Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
44.44Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
43.75Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
43.75Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
43.75Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
43.75Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
43.75Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
43.75Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
42.86Single4UG2CGS216804UG2-A2A-CGS21680
42.86Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
42.86Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
42.86Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
42.11Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
42.11Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
42.11Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
42.11Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
42.11Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
42.11Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
42.11Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
42.11Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
42.11Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
42.11Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
42.11Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
42.11Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
42.11Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
42.11Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
41.18Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
41.18Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
41.18Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
41.18Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
41.18Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
41.18Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
41.18Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
41.18Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
41.18Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
41.18Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
41.18Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
41.18Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
41.18Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
40.91Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
40.00Single3D4STimolol3D4S-β2-Timolol
40.00Single4AMIBucindolol4AMI-β1-Bucindolol
40.00Single6A93Risperidone6A93-5-HT2A-Risperidone
40.00Single6CM4Risperidone6CM4-D2-Risperidone
40.00Single6MXTSalmeterol6MXT-β2-Salmeterol
40.00Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
40.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
40.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
40.00Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
40.00Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
40.00Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
40.00Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
40.00Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
40.00Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
40.00Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
40.00Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
40.00Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
40.00Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
40.00Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
40.00Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
39.13Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
38.89Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
38.89Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
38.89Single6DRXLisuride6DRX-5-HT2B-Lisuride
38.89Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
38.89Single6PS1Timolol6PS1-β2-Timolol
38.89Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
38.89Single7WC7Lisuride7WC7-5-HT2A-Lisuride
38.89Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
38.89Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
38.89Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
38.89Single8JJOAlprenolol8JJO-β2-Alprenolol
38.89Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
38.89Single8JXRLSD8JXR-D1-LSD
38.89Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
38.89Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
38.89Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
38.89Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
38.89Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
38.89Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
38.89Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
38.89Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
38.89Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
38.10Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
38.10Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
38.10Single6IBLArformoterol6IBL-β1-Arformoterol
38.10Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
38.10Single7EZCUKA7EZC-A2A-UKA
38.10Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
38.10Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
38.10Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
38.10Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
38.10Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
38.10Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
37.50Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
37.50Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
37.50Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
37.50Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
37.50Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
37.50Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
37.50Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
37.50Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
37.50Consensusangiotensin_onOrthosteric Ligandat1_on
37.50Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
37.50Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
37.50Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
37.50Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
37.04Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
36.84Single2RH1S-Carazolol2RH1-β2-S-Carazolol
36.84Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
36.84Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
36.84Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
36.84Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
36.84Single7C61Ergotamine7C61-5-HT1B-Ergotamine
36.84Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
36.84Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
36.84Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
36.84Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
36.84Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
36.84Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
36.84Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
36.84Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.84Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.84Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.84Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.84Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.84Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
36.84Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
36.84Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
36.84Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
36.84Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
36.84Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
36.84Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
36.84Consensusamine_offonOrthosteric Ligandamine_off amine_on
36.84Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
36.84Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
36.84Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
36.84Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
36.84Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
36.84Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
36.84Consensustrace-amine_onOrthosteric Ligandta1_on
36.36Single3NY9ICI118-5513NY9-β2-ICI118-551
36.36Single5WF6UK-4320975WF6-A2A-UK-432097
36.36Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
36.36Single7SK9CCX6627SK9-ACKR3-CCX662
36.36Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
36.36Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
36.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
36.00Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
36.00Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
36.00Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
36.00Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
36.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
36.00Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
35.71Single6IGLIRL16206IGL-ETB-IRL1620
35.71Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
35.29Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.29Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
35.29Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
35.29Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
35.29Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.29Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
35.29Single8GNGIstradefylline8GNG-A2A-Istradefylline
35.29Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
35.29Single8IWESpermidine8IWE-TA9-Spermidine
35.29Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
35.29Single8Y0HVUF114188Y0H-CXCR3-VUF11418
35.29Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
35.29Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
35.29Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
35.29Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.29Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
35.29Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
35.00Single2YDVNECA2YDV-A2A-NECA
35.00Single3P0GBI1671073P0G-β2-BI167107
35.00Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
35.00Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
35.00Single4UHRCGS216804UHR-A2A-CGS21680
35.00Single5D5AS-Carazolol5D5A-β2-S-Carazolol
35.00Single5D5BS-Carazolol5D5B-β2-S-Carazolol
35.00Single5G53NECA5G53-A2A-NECA-Gs
35.00Single6TQ7SB-3348676TQ7-OX1-SB-334867
35.00Single6WGTLSD6WGT-5-HT2A-LSD
35.00Single7B6WCyclazosin7B6W-α1b-Cyclazosin
35.00Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
35.00Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
35.00Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
35.00Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
35.00Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
35.00Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
35.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
35.00Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
35.00Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
35.00Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
35.00Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
35.00Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
35.00Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
35.00Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
35.00Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
35.00Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
35.00Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
35.00Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
35.00Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
34.78Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
34.78Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
34.78Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
34.78Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
34.78Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
34.78Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
34.78Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
34.78Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
34.78Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
33.33Single2YDOAdenosine2YDO-A2A-Adenosine
33.33Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
33.33Single4RWADIPP-NH24RWA-δ-DIPP-NH2
33.33Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
33.33Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
33.33Single6A94Zotepine6A94-5-HT2A-Zotepine
33.33Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
33.33Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
33.33Single6MH8ZM-2413856MH8-A2A-ZM-241385
33.33Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
33.33Single6PS5S-Propranolol6PS5-β2-S-Propranolol
33.33Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
33.33Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
33.33Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
33.33Single7DFPSpiperone7DFP-D2-Spiperone
33.33Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
33.33Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
33.33Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
33.33Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
33.33Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
33.33Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
33.33Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
33.33Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
33.33Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
33.33Single7T32ZM-2413857T32-A2A-ZM-241385
33.33Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
33.33Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
33.33Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
33.33Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
33.33Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
33.33Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
33.33Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
33.33Single7YITNalfurafine7YIT-κ-Nalfurafine
33.33Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
33.33Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
33.33Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
33.33Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
33.33Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
33.33Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
33.33Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
33.33Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
33.33Single8JJ8Formoterol8JJ8-β2-Formoterol
33.33Single8JJLOlodaterol8JJL-β2-Olodaterol
33.33Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
33.33Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
33.33Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
33.33Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
33.33Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
33.33Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
33.33Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
33.33Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
33.33Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
33.33Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
33.33Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
33.33Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
33.33Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
33.33Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
33.33Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
33.33Single9CHUNoradrenaline9CHU-β2-Noradrenaline
33.33Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
33.33Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
33.33Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
33.33Consensusalpha1_onOrthosteric Ligandalpha1a_on
33.33Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
33.33Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
33.33Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
33.33Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
33.33Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
33.33Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
33.33Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
33.33Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
33.33Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
33.33Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
33.33Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
33.33Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
33.33Consensusorexin_onOrthosteric Ligandox2_on
33.33Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
33.33Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
33.33Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
33.33Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
32.14Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
32.14Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
32.14Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
32.14Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
32.14Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
32.00Single6PT2KGCHM076PT2-δ-KGCHM07
32.00Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
32.00Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
32.00Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
32.00Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
32.00Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
32.00Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
32.00Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
31.82Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
31.82Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
31.82Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
31.82Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
31.82Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
31.82Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
31.82Single7UM4AS26747237UM4-5-HT5A-AS2674723
31.82Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
31.82Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
31.82Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
31.82Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
31.82Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
31.82Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
31.82Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58Single2Y02Carmoterol2Y02-β1-Carmoterol
31.58Single3EMLZM-2413853EML-A2A-ZM-241385
31.58Single3NY8ICI118-5513NY8-β2-ICI118-551
31.58Single4EJ4Naltrindole4EJ4-δ-Naltrindole
31.58Single4GBRS-Carazolol4GBR-β2-S-Carazolol
31.58Single4QKX35V4QKX-β2-35V
31.58Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
31.58Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
31.58Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
31.58Single6D27CAY104716D27-DP2-CAY10471
31.58Single6H7MSalbutamol6H7M-β1-Salbutamol
31.58Single6S0LZM-2413856S0L-A2A-ZM-241385
31.58Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
31.58Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
31.58Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
31.58Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
31.58Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
31.58Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
31.58Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
31.58Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
31.58Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
31.58Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
31.58Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
31.58Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
31.58Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
31.58Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
31.58Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
31.58Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
31.58Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
31.58Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
31.58Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
31.58Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
31.58Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
31.58Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
31.58Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
31.58Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
31.58Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
31.58Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
31.58Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
31.58Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
31.58Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
31.58Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
31.58Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
31.58Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
31.58Single8X64Desloratadine8X64-H1-Desloratadine
31.58Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
31.58Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
31.58Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
31.58Single9CHXS-Carazolol9CHX-β2-S-Carazolol
31.58Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
31.58Consensus5ht5_onOrthosteric Ligand5ht5a_on
31.58Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
31.58Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
31.58Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
31.58Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
31.58Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
31.58Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
31.58Consensusdopamine_offOrthosteric Ligandd2_off d3_off
31.58Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
31.58Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
31.58Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
31.25Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
31.25Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
31.25Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
31.25Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
31.25Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.25Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.25Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
31.25Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
31.25Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
31.25Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Consensus5ht2_onOrthosteric Ligand5ht2b_on
31.25Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.25Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
31.03Consensusendothelin_onOrthosteric Ligandetb_on eta_on
30.77Single6JODAngiotensin II6JOD-AT2-Angiotensin II
30.77Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
30.77Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
30.77Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
30.77Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
30.77Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
30.43Single5ZTYAM102575ZTY-CB2-AM10257
30.43Single6PT3DPI-2876PT3-δ-DPI-287
30.43Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
30.43Single7XN9L-054,5227XN9-SST2-L-054,522
30.43Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
30.43Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
30.43Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
30.43Single8X5YAstemizole8X5Y-H1-Astemizole
30.43Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
30.43Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
30.43Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
30.43Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
30.43Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
30.00Single2Y03Isoprenaline2Y03-β1-Isoprenaline
30.00Single2YCWS-Carazolol2YCW-β1-S-Carazolol
30.00Single5C1MBU725C1M-μ-BU72
30.00Single5D6LS-Carazolol5D6L-β2-S-Carazolol
30.00Single5GLHEndothelin-15GLH-ETB-Endothelin-1
30.00Single5IUAQ274563485IUA-A2A-Q27456348-Na
30.00Single5N2RPSB-365N2R-A2A-PSB-36-Na
30.00Single5N2SPSB365N2S-A1-PSB36
30.00Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
30.00Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
30.00Single6D26Fevipiprant6D26-DP2-Fevipiprant
30.00Single6E67BI1671076E67-β2-BI167107-Gs (fused)
30.00Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
30.00Single6IGKEndothelin-36IGK-ETB-Endothelin-3
30.00Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
30.00Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
30.00Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
30.00Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
30.00Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
30.00Single6PS6Timolol6PS6-β2-Timolol
30.00Single6S0QZM-2413856S0Q-A2A-ZM-241385
30.00Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
30.00Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
30.00Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
30.00Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
30.00Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
30.00Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
30.00Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
30.00Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
30.00Single7WC6LSD7WC6-5-HT2A-LSD
30.00Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.00Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
30.00Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
30.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
30.00Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
30.00Single8JXSPF-61428JXS-D1-PF-6142
30.00Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
30.00Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
30.00Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
30.00Consensusa3_on_gpOrthosteric Liganda3a_on_gp
30.00Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
30.00Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
30.00Consensusadenosine_offOrthosteric Liganda1_off a2_off
30.00Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
30.00Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
30.00Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
30.00Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
30.00Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
30.00Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
30.00Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
30.00Consensusdp_offOrthosteric Liganddp2_off
30.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
30.00Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
30.00Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
30.00Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
30.00Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
29.63Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
29.63Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.63Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
29.63Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Single8ZRTET-18ZRT-ETB-ET-1
29.63Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
29.63Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
29.41Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
29.41Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
29.41Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
29.41Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
29.41Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
29.41Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
29.41Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
29.41Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
29.41Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
29.41Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
29.41Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
29.41Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
29.17Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
29.17Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
29.17Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
29.17Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
29.17Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
29.17Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
29.17Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
29.03Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
29.03Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
28.57Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
28.57Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
28.57Single5TZRMK86665TZR-FFA1-MK8666
28.57Single5V54Methiothepin5V54-5-HT1B-Methiothepin
28.57Single6E59L-7607356E59-NK1-L-760735
28.57Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
28.57Single6H7JIsoprenaline6H7J-β1-Isoprenaline
28.57Single6J20Aprepitant6J20-NK1-Aprepitant
28.57Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
28.57Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
28.57Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
28.57Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
28.57Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
28.57Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
28.57Single7PX4PSB-21137PX4-A2A-PSB-2113
28.57Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
28.57Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
28.57Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
28.57Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
28.57Single8E0GBU728E0G-μ-BU72
28.57Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
28.57Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
28.57Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
28.57Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
28.57Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
28.57Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
28.57Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
28.57Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
28.57Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
28.57Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
28.57Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
28.57Consensus5ht1_offOrthosteric Ligand5ht1b_off
28.57Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
28.57Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
28.57Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
28.57Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
28.57Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
28.57Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
28.57Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
28.57Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
28.57Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
28.57Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
28.57Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
28.12Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
28.00Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
28.00Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
28.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
28.00Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
28.00Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
28.00Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
28.00Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
28.00Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
28.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
28.00Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
28.00Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
28.00Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
27.78Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
27.78Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
27.78Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
27.78Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
27.78Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
27.78Single6AKXA4R6AKX-CCR5-A4R
27.78Single6AKYMaraviroc6AKY-CCR5-Maraviroc
27.78Single6DS0Ly2660976DS0-5-HT2B-Ly266097
27.78Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
27.78Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
27.78Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
27.78Single7F8ULintitript7F8U-CCKA-Lintitript
27.78Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
27.78Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
27.78Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
27.78Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
27.78Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
27.78Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
27.78Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
27.78Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
27.78Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
27.78Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
27.78Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
27.78Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
27.78Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
27.78Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
27.78Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
27.78Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
27.78Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
27.78Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
27.78Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
27.78Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
27.78Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
27.78Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
27.78Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
27.78Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
27.78Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
27.78Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
27.78Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
27.78Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
27.78Consensusalpha2_offOrthosteric Ligandalpha2c_off
27.78Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
27.78Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
27.78Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
27.78Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
27.78Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
27.59Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
27.59Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
27.59Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
27.59Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
27.59Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
27.59Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
27.27Single4LDEBI1671074LDE-β2-BI167107
27.27Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
27.27Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
27.27Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
27.27Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
27.27Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
27.27Single7K15MKD0467K15-BLT1-MKD046-Na
27.27Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
27.27Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
27.27Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
27.27Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
27.27Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
27.27Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
27.27Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
27.27Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
27.27Consensusalpha1_offOrthosteric Ligandalpha1a_off
27.27Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
27.27Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
27.27Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
27.27Consensuslpa_offOrthosteric Ligandlpa1_off
27.27Consensuslpl_offOrthosteric Ligands1p_off lpa_off
27.27Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
27.27Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
27.27Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
27.27Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
26.92Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
26.92Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
26.92Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
26.92Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
26.92Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
26.92Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
26.92Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
26.92Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
26.92Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
26.67Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
26.67Single7WC4Serotonin7WC4-5-HT2A-Serotonin
26.67Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
26.67Single8IY6Endothelin-18IY6-ETB-Endothelin-1
26.67Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
26.32Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
26.32Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
26.32Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
26.32Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
26.32Single4MBSMaraviroc4MBS-CCR5-Maraviroc
26.32Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
26.32Single5IU7Q274563465IU7-A2A-Q27456346-Na
26.32Single5JTBZM-2413855JTB-A2A-ZM-241385
26.32Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
26.32Single5UVIZM-2413855UVI-A2A-ZM-241385
26.32Single6KUXRS-799486KUX-α2a-RS-79948
26.32Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
26.32Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
26.32Single6PS0S-Carazolol6PS0-β2-S-Carazolol
26.32Single6PS4ICI118-5516PS4-β2-ICI118-551
26.32Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
26.32Single6TPNHTL66416TPN-OX2-HTL6641
26.32Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
26.32Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
26.32Single7AROLUF58337ARO-A2A-LUF5833-Na
26.32Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
26.32Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
26.32Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
26.32Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
26.32Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.32Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
26.32Single7VODCariprazine7VOD-5-HT2A-Cariprazine
26.32Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
26.32Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
26.32Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
26.32Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
26.32Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
26.32Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
26.32Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
26.32Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
26.32Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
26.32Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
26.32Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
26.32Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
26.32Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
26.32Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Single9BJKNaloxone9BJK-μ-Naloxone-NAM
26.32Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
26.32Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
26.32Consensusa2_offOrthosteric Liganda2a_off
26.32Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
26.32Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
26.32Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
26.32Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
26.32Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
26.32Consensusopsins_offOrthosteric Ligandrhodopsin_off
26.32Consensussensory_offOrthosteric Ligandopsins_off
26.09Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
26.09Single5X93K-87945X93-ETB-K-8794
26.09Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
26.09Single6H7LDobutamine6H7L-β1-Dobutamine
26.09Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.09Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
26.09Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
26.09Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
26.09Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
26.09Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
26.09Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
26.09Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
26.09Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
26.09Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
26.09Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
26.09Consensuscck_onOrthosteric Ligandccka_on cckb_on
26.09Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
26.09Consensuschemerin_onOrthosteric Ligandcml1_on
26.09Consensusendothelin_offOrthosteric Ligandetb_off
26.09Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
26.09Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
26.09Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
26.09Consensusprostanoid_offOrthosteric Ligandep_off dp_off
25.93Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
25.93Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
25.93Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
25.93Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
25.93Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.93Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
25.93Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
25.93Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
25.93Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
25.93Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
25.93Consensusvasop-oxy_onOrthosteric Ligandv2_on
25.93Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
25.81Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
25.81Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
25.81Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
25.81Consensusbombesin_onOrthosteric Ligandbb2_on
25.81Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
25.81Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
25.81Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
25.81Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
25.81Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
25.81Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
25.00Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
25.00Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
25.00Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
25.00Single2Y04Salbutamol2Y04-β1-Salbutamol
25.00Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
25.00Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
25.00Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
25.00Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
25.00Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
25.00Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
25.00Single5IU8Q274563475IU8-A2A-Q27456347-Na
25.00Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
25.00Single5TGZAM65385TGZ-CB1-AM6538
25.00Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
25.00Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
25.00Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
25.00Single6TOTLemborexant6TOT-OX1-Lemborexant
25.00Single7BU7BI1671077BU7-β1-BI167107
25.00Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
25.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
25.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
25.00Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
25.00Single7PYRPSB-21157PYR-A2A-PSB-2115
25.00Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
25.00Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
25.00Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
25.00Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
25.00Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
25.00Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
25.00Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
25.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
25.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
25.00Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
25.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
25.00Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
25.00Single8CU6LJ-45178CU6-A2A-LJ-4517
25.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
25.00Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
25.00Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
25.00Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
25.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
25.00Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
25.00Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
25.00Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
25.00Single8QJ2pN1628QJ2-MC4-pN162-Gs
25.00Single8RLNLUF58348RLN-A2A-LUF5834
25.00Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
25.00Single8T1WCVN4248T1W-GPR6-CVN424
25.00Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
25.00Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
25.00Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
25.00Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
25.00Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
25.00Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
25.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
25.00Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
25.00Consensusa3_onOrthosteric Liganda3a_on
25.00Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
25.00Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
25.00Consensusblt_onOrthosteric Ligandblt1_on
25.00Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
25.00Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
25.00Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
25.00Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
25.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
25.00Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
25.00Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
25.00Consensusleukotriene_onOrthosteric Ligandblt_on
25.00Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
25.00Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
25.00Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
25.00Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
25.00Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
25.00Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
24.24Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
24.14Single6FJ3PTH6FJ3-PTH1-PTH
24.14Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
24.14Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
24.14Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
24.00Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
24.00Single7F8XNN90567F8X-CCKA-NN9056
24.00Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
24.00Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
24.00Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
24.00Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
24.00Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
24.00Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
24.00Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
24.00Consensuslpl_onOrthosteric Ligands1p_on lpa_on
24.00Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
24.00Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
24.00Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
24.00Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
24.00Consensussomatostatin_offOrthosteric Ligandsst2_off
23.81Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
23.81Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
23.81Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
23.81Single5CGCHTL142425CGC-mGlu5-HTL14242
23.81Single5JQHS-Carazolol5JQH-β2-S-Carazolol
23.81Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
23.81Single5TVNLSD5TVN-5-HT2B-LSD
23.81Single5WIUNemonapride5WIU-D4-Nemonapride
23.81Single5WIVNemonapride5WIV-D4-Nemonapride-Na
23.81Single5XPRBosentan5XPR-ETB-Bosentan
23.81Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
23.81Single6LUQHaloperidol6LUQ-D2-Haloperidol
23.81Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
23.81Single6TP6Filorexant6TP6-OX1-Filorexant
23.81Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
23.81Single7C4SS1P7C4S-S1P3-S1P
23.81Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
23.81Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
23.81Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
23.81Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
23.81Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.81Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
23.81Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.81Single8GNEKW-63568GNE-A2A-KW-6356-Na
23.81Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
23.81Single8QOTNanobody-E8QOT-μ-Nanobody-E
23.81Single8S4DCMF-0198S4D-Apelin-CMF-019
23.81Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
23.81Single8TF5Oleic acid8TF5-GPR6-Oleic acid
23.81Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
23.81Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
23.81Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
23.81Single8ZMFA1L108ZMF-5-HT2C-A1L10
23.81Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
23.81Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
23.81Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
23.81Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
23.81Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
23.53Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
23.53Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
23.53Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
23.53Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
23.53Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
23.53Single7WC5Psilocin7WC5-5-HT2A-Psilocin
23.53Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
23.53Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.53Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
23.53Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
23.53Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
23.53Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
23.53Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
23.53Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
23.33Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
23.33Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
23.33Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
23.08Single6HLOAprepitant6HLO-NK1-Aprepitant
23.08Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
23.08Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
23.08Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
23.08Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
23.08Single7XNACYN1548067XNA-SST2-CYN154806
23.08Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
23.08Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
23.08Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
23.08Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
23.08Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
23.08Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
23.08Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
23.08Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
23.08Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
23.08Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
23.08Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
22.73Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
22.73Single4DJHJDTic4DJH-κ-JDTic
22.73Single5XR8AM8415XR8-CB1-AM841
22.73Single5XRAAM115425XRA-CB1-AM11542
22.73Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
22.73Single6J21Aprepitant6J21-NK1-Aprepitant
22.73Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
22.73Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
22.73Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
22.73Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
22.73Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
22.73Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
22.73Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
22.73Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
22.73Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
22.73Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
22.73Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
22.73Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
22.73Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
22.73Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
22.73Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
22.73Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
22.73Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
22.73Single8XVLZibotentan8XVL-ETA-Zibotentan
22.73Consensusa2_onOrthosteric Liganda2b_on
22.73Consensusa2_on_gpOrthosteric Liganda2b_on_gp
22.73Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
22.73Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
22.73Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
22.73Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
22.73Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
22.73Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
22.73Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
22.73Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
22.73Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Consensustachykinin_offOrthosteric Ligandnk1_off
22.58Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
22.58Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
22.58Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
22.58Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
22.58Consensusbradykinin_onOrthosteric Ligandbk2_on
22.58Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
22.58Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
22.22Single3OE0CVX153OE0-CXCR4-CVX15
22.22Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
22.22Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
22.22Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
22.22Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
22.22Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
22.22Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
22.22Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
22.22Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
22.22Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
22.22Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
22.22Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
22.22Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
22.22Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
22.22Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
22.22Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.22Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
22.22Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
22.22Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
22.22Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
22.22Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
22.22Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
22.22Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
22.22Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
22.22Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
21.88Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
21.74Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
21.74Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
21.74Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
21.74Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
21.74Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
21.74Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
21.74Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
21.74Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
21.74Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
21.74Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.74Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
21.74Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
21.74Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
21.74Single8JWY2-1188JWY-A2A-2-118
21.74Single8JWZAB9288JWZ-A2A-AB928-Na
21.74Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
21.74Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
21.74Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
21.74Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
21.74Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
21.74Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
21.74Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
21.74Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.74Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.43Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
21.43Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
21.43Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
21.43Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
21.43Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
21.43Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
21.43Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
21.43Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
21.43Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
21.43Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
21.21Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
21.05Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
21.05Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
21.05Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
21.05Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
21.05Single4S0VSuvorexant4S0V-OX2-Suvorexant
21.05Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
21.05Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
21.05Single6B73MP11046B73-κ-MP1104
21.05Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
21.05Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
21.05Single6ME2Ramelteon6ME2-MT1-Ramelteon
21.05Single6ME9Ramelteon6ME9-MT2-Ramelteon
21.05Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
21.05Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
21.05Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
21.05Single6TODEMPA6TOD-OX1-EMPA-Na
21.05Single6TPJSuvorexant6TPJ-OX2-Suvorexant
21.05Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
21.05Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
21.05Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
21.05Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
21.05Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
21.05Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
21.05Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
21.05Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
21.05Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
21.05Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
21.05Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
21.05Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
21.05Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
21.05Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
21.05Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
21.05Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
21.05Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
21.05Consensusorexin_offOrthosteric Ligandox2_off ox1_off
21.05Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
21.05Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
20.83Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
20.83Single5CGDHTL142425CGD-mGlu5-HTL14242
20.83Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
20.83Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
20.83Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
20.83Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
20.83Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
20.83Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
20.83Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
20.83Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
20.83Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single8XVJMacitentan8XVJ-ETA-Macitentan
20.83Single8XVUCXCL28XVU-CXCR2-CXCL2
20.83Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
20.83Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
20.83Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
20.83Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
20.83Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
20.83Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
20.69Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
20.69Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
20.69Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
20.69Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
20.69Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
20.69Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
20.69Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
20.69Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
20.69Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
20.69Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
20.69Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
20.59Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
20.00Single3REYXAC3REY-A2A-XAC
20.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
20.00Single4XT3Fractalkine4XT3-US28-Fractalkine
20.00Single4ZJCSB-6740424ZJC-OX1-SB-674042
20.00Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
20.00Single5IUBQ274563445IUB-A2A-Q27456344-Na
20.00Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
20.00Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
20.00Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
20.00Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
20.00Single6AQFZM-2413856AQF-A2A-ZM-241385
20.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
20.00Single6FFIMMPEP6FFI-mGlu5-MMPEP
20.00Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
20.00Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
20.00Single6TP3Nemorexant6TP3-OX1-Nemorexant
20.00Single6TPGEMPA6TPG-OX2-EMPA
20.00Single6TPKRetosiban6TPK-OT-Retosiban
20.00Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
20.00Single6VI4JDTic6VI4-κ-JDTic
20.00Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
20.00Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
20.00Single6ZG9GSK10347026ZG9-M1-GSK1034702
20.00Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
20.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
20.00Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
20.00Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
20.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
20.00Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
20.00Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
20.00Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
20.00Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
20.00Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
20.00Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
20.00Single8IHKAcifran8IHK-HCA3-Acifran
20.00Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
20.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
20.00Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
20.00Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
20.00Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
20.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
20.00Single8XQJJN2418XQJ-Apelin-JN241
20.00Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
20.00Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
20.00Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
20.00Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
20.00Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
20.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
20.00Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
20.00Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
20.00Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
20.00Consensusgrh_offOrthosteric Ligandgnrh1_off
20.00Consensushca_onOrthosteric Ligandhca2_on
20.00Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
20.00Consensuskisspeptin_onOrthosteric Ligandkiss1_on
20.00Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
20.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
20.00Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
20.00Consensusvasop-oxy_offOrthosteric Ligandot_off
19.44Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
19.35Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
19.35Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
19.35Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
19.35Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
19.35Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
19.23Single4XT1Fractalkine4XT1-US28-Fractalkine
19.23Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
19.23Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
19.23Single7QA8Peptide7QA8-STE2-Peptide
19.23Single7QA8Peptide7QA8-STE2-Peptide
19.23Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
19.23Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
19.23Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
19.23Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
19.23Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
19.23Single8IEBA1LYA8IEB-GPR156-A1LYA
19.23Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
19.23Single8WKYPG-9348WKY-MC4-PG-934
19.23Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.23Single8XWNCXCL88XWN-CXCR2-CXCL8
19.23Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
19.23Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
19.23Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
19.23Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
19.23Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single2Y01Dobutamine2Y01-β1-Dobutamine
19.05Single5DHGC-355DHG-NOP-C-35
19.05Single5DHHSB-6121115DHH-NOP-SB-612111
19.05Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
19.05Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
19.05Single5UENDU1725UEN-A1-DU172
19.05Single5UIGCmpd-15UIG-A2A-Cmpd-1
19.05Single6FFHFenobam6FFH-mGlu5-Fenobam
19.05Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
19.05Single7F83PF-051904577F83-Ghrelin-PF-05190457
19.05Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
19.05Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
19.05Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
19.05Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
19.05Single7UL4Alvimopan7UL4-μ-Alvimopan
19.05Single7V3ZCP559407V3Z-CB1-CP55940
19.05Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
19.05Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
19.05Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.05Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
19.05Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
19.05Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
19.05Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
19.05Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
19.05Single8K5DGSK2560738K5D-HCA2-GSK256073
19.05Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
19.05Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
19.05Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
19.05Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
19.05Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
19.05Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
19.05Consensuscck_offOrthosteric Ligandccka_off
19.05Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
19.05Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
19.05Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
19.05Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
19.05Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
19.05Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
19.05Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
19.05Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
19.05Consensushca_on_gpOrthosteric Ligandhca2_on_gp
19.05Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
18.92Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
18.92Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
18.75Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
18.75Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
18.75Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
18.75Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
18.75Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
18.75Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
18.75Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
18.75Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
18.75Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
18.75Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
18.52Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
18.52Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
18.52Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
18.52Single7SK5CXCL127SK5-ACKR3-CXCL12
18.52Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
18.18Single2Y00Dobutamine2Y00-β1-Dobutamine
18.18Single4NTJAZD12834NTJ-P2Y12-AZD1283
18.18Single5WQCEMPA5WQC-OX2-EMPA
18.18Single6HLPNetupitant6HLP-NK1-Netupitant
18.18Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
18.18Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
18.18Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
18.18Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
18.18Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
18.18Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
18.18Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
18.18Single7SINNPS-21437SIN-CaS-NPS-2143
18.18Single7SINNPS-21437SIN-CaS-NPS-2143
18.18Single7W41PD1762527W41-BB2-PD176252
18.18Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
18.18Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
18.18Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
18.18Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
18.18Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
18.18Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
18.18Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
18.18Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
18.18Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
18.18Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
18.18Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
18.18Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
18.18Consensusbombesin_offOrthosteric Ligandbb2_off
18.18Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
18.18Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
18.18Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
18.18Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
17.86Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
17.86Single6W25SHU91196W25-MC4-SHU9119-Ca
17.86Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
17.86Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
17.86Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
17.86Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.86Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
17.86Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
17.86Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
17.86Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
17.86Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
17.86Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
17.65Single3RFMCaffeine3RFM-A2A-Caffeine
17.65Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
17.65Single8A2OTheophylline8A2O-A2A-Theophylline-Na
17.65Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
17.65Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
17.65Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
17.65Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
17.65Consensussensory_onOrthosteric Ligandopsins_on
17.39Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
17.39Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
17.39Single6OS1TRV0266OS1-AT1-TRV026
17.39Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
17.39Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
17.39Single7F1TMIP-1a7F1T-CCR5-MIP-1a
17.39Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
17.39Single7FEECP559407FEE-CB1-CP55940-ZCZ011
17.39Single7P2L4YI7P2L-mGlu5-4YI
17.39Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
17.39Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
17.39Single7TUYGSK682753A7TUY-GPR183-GSK682753A
17.39Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
17.39Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
17.39Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
17.39Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
17.39Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
17.39Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
17.39Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
17.39Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
17.39Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
17.39Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
17.39Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
17.39Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
17.39Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
17.39Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
17.39Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
17.39Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
17.39Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
17.39Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
17.39Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
17.39Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
17.24Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
17.24Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
17.24Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
17.24Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
17.24Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
17.24Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
17.24Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
17.24Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
17.24Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
17.24Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
17.14Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
16.67Single3OE6IT1t3OE6-CXCR4-IT1t
16.67Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
16.67Single4N4WSANT-14N4W-SMO-SANT-1
16.67Single4XNWMRS25004XNW-P2Y1-MRS2500
16.67Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
16.67Single6KQICP559406KQI-CB1-CP55940-Org27569
16.67Single6ME5Agomelatine6ME5-MT1-Agomelatine
16.67Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
16.67Single6OS2TRV0266OS2-AT1-TRV026
16.67Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
16.67Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
16.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
16.67Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
16.67Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
16.67Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
16.67Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
16.67Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
16.67Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
16.67Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
16.67Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
16.67Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
16.67Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
16.67Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
16.67Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
16.67Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
16.67Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
16.67Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
16.67Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
16.67Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
16.67Single8XWACXCL18XWA-CXCR2-CXCL1
16.67Single8XWMCXCL68XWM-CXCR2-CXCL6
16.67Single8XWSCXCL58XWS-CXCR2-CXCL5
16.67Single8XYIVUF106618XYI-CXCR3-VUF10661
16.67Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
16.67Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
16.67Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
16.67Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
16.67Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
16.67Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
16.67Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
16.67Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
16.67Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
16.67Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
16.67Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
16.67Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
16.67Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
16.67Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
16.67Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
16.67Consensusgi_sensoryOrthosteric Ligandgi_opsins
16.67Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
16.67Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
16.67Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
16.67Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
16.67Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
16.67Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
16.67Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
16.67Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
16.67Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
16.28Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
16.13Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
16.13Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
16.13Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
16.13Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
16.13Single7SK3CXCL127SK3-ACKR3-CXCL12
16.13Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
16.13Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
16.13Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
16.13Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
16.13Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
16.00Single6K1QIRL25006K1Q-ETB-IRL2500
16.00Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
16.00Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
16.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
16.00Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
16.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
16.00Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
16.00Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
16.00Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single8XWFCXCL38XWF-CXCR2-CXCL3
16.00Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
16.00Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
16.00Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
16.00Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
16.00Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
15.79Single3OE9IT1t3OE9-CXCR4-IT1t
15.79Single3PBLEticlopride3PBL-D3-Eticlopride
15.79Single6HLLCP999946HLL-NK1-CP99994
15.79Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
15.79Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
15.79Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
15.79Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
15.79Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
15.79Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
15.79Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
15.79Single8K5BNiacin8K5B-HCA2-Niacin
15.79Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
15.79Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
15.79Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
15.79Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
15.79Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
15.79Single9B9Y7DY9B9Y-CB1-7DY
15.79Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
15.79Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
15.79Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
15.79Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
15.62Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
15.62Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
15.62Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
15.62Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
15.62Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
15.62Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
15.62Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
15.38Single5EE7MK08935EE7-Glucagon-MK0893
15.38Single6KNMJN241-96KNM-Apelin-JN241-9
15.38Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
15.38Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
15.38Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
15.38Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
15.38Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
15.38Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
15.15Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
15.15Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
15.15Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
15.15Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
15.15Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
15.15Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
15.15Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
15.15Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
15.00Single3ODUIT1t3ODU-CXCR4-IT1t
15.00Single3PWHZM-2413853PWH-A2A-ZM-241385
15.00Single4BWBNeurotensin4BWB-NTS1-Neurotensin
15.00Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
15.00Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
15.00Single5U09Taranabant5U09-CB1-Taranabant
15.00Single5WS3EMPA5WS3-OX2-EMPA
15.00Single5ZKQABT-4915ZKQ-PAF-ABT-491
15.00Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
15.00Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
15.00Single7BR3Elagolix7BR3-GnRH1-Elagolix
15.00Single7F8YDevazepide7F8Y-CCKA-Devazepide
15.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
15.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
15.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
15.00Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
15.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
15.00Single7XRRLemborexant7XRR-OX2-Lemborexant
15.00Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
15.00Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
15.00Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
15.00Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
15.00Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
15.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
15.00Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
15.00Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
15.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
15.00Consensusangiotensin_offOrthosteric Ligandat1_off
15.00Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
15.00Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
15.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
15.00Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
15.00Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
15.00Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
15.00Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
15.00Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
15.00Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
14.81Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
14.81Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
14.81Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
14.81Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
14.81Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
14.81Single8KIGSHU91198KIG-MC3-SHU9119-Ca
14.81Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
14.81Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
14.81Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
14.81Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
14.71Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
14.29Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
14.29Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
14.29Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
14.29Single6IQLL7458706IQL-D4-L745870
14.29Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
14.29Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
14.29Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
14.29Single6V9SGTPL114036V9S-OX1-GTPL11403
14.29Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
14.29Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
14.29Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
14.29Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
14.29Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
14.29Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
14.29Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
14.29Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
14.29Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
14.29Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
14.29Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
14.29Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
14.29Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
14.29Single8K5CAcipimox8K5C-HCA2-Acipimox
14.29Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
14.29Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
14.29Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
14.29Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
14.29Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
14.29Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
14.29Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
14.29Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
14.29Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
13.89Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
13.89Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
13.79Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
13.79Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
13.79Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
13.79Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
13.79Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
13.64Single4YAYZD-71554YAY-AT1-ZD-7155
13.64Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
13.64Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
13.64Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
13.64Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
13.64Single6GPSMK08126GPS-CCR2-MK0812
13.64Single6IIVDaltroban6IIV-TP-Daltroban
13.64Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
13.64Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
13.64Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
13.64Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
13.64Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
13.64Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
13.64Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
13.64Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
13.64Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
13.64Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
13.64Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
13.64Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
13.64Single9B9ZA1AKO9B9Z-CB1-A1AKO
13.64Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
13.64Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
13.51Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
13.33Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
13.33Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
13.33Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
13.33Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
13.33Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
13.33Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
13.33Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
13.33Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
13.04Single4JKVTaladegib4JKV-SMO-Taladegib
13.04Single6GPXMK08126GPX-CCR2-MK0812
13.04Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
13.04Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
13.04Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
13.04Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
13.04Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
13.04Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
13.04Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
13.04Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
13.04Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
13.04Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
13.04Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
13.04Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
13.04Consensusblt_offOrthosteric Ligandblt1_off
13.04Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
13.04Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
12.90Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
12.50Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
12.50Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
12.50Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
12.50Single5MZPCaffeine5MZP-A2A-Caffeine-Na
12.50Single5V56TC1145V56-SMO-TC114
12.50Single5V57TC1145V57-SMO-TC114
12.50Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
12.50Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
12.50Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
12.50Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
12.50Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
12.50Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
12.50Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
12.50Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
12.50Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
12.50Single7R0CAVP7R0C-V2-AVP-Arrestin2
12.50Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
12.50Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
12.50Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
12.50Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
12.50Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
12.50Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
12.50Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
12.50Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
12.50Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
12.50Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
12.50Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
12.50Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
12.50Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
12.50Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
12.50Consensuslpa_onOrthosteric Ligandlpa1_on
12.50Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
12.50Consensusneurotensin_onOrthosteric Ligandnts1_on
12.50Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
12.50Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
12.50Consensusrelaxin_onOrthosteric Ligandrxfp4_on
12.50Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
12.20Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
12.12Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
12.12Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
12.12Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
12.12Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
12.12Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
12.00Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
12.00Single4XEENeurotensin4XEE-NTS1-Neurotensin
12.00Single4XESNeurotensin4XES-NTS1-Neurotensin
12.00Single5X33BIIL2605X33-BLT1-BIIL260
12.00Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
12.00Single6IIURamatroban6IIU-TP-Ramatroban
12.00Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
12.00Single6YVRNTS8-136YVR-NTS1-NTS8-13
12.00Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
12.00Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
12.00Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
12.00Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
12.00Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
12.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
12.00Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
12.00Single8XQJJN2418XQJ-Apelin-JN241
12.00Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
12.00Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
12.00Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
12.00Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
12.00Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
11.90Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
11.76Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
11.76Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
11.76Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
11.76Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
11.76Single8PWNTheophylline8PWN-A2A-Theophylline
11.76Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
11.76Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
11.54Single4BUONeurotensin4BUO-NTS1-Neurotensin
11.54Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
11.54Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
11.54Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
11.54Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
11.54Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
11.54Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
11.54Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
11.54Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
11.54Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
11.43Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
11.11Single3OE8IT1t3OE8-CXCR4-IT1t
11.11Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
11.11Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
11.11Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
11.11Single6TQ9SB-4081246TQ9-OX1-SB-408124
11.11Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
11.11Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
11.11Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
11.11Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
11.11Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
11.11Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
11.11Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
11.11Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
11.11Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
11.11Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
11.11Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
11.11Consensusp2y_offOrthosteric Ligandp2y1_off
10.81Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
10.81Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
10.71Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
10.71Single8IEIA1LYA8IEI-GPR156-A1LYA
10.71Single8IEPA1LYA8IEP-GPR156-A1LYA
10.71Single8IEPA1LYA8IEP-GPR156-A1LYA
10.71Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
10.71Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
10.71Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
10.53Single3UZAGTPL92363UZA-A2A-GTPL9236
10.53Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
10.53Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
10.53Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
10.53Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
10.53Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
10.53Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
10.53Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
10.53Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
10.53Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
10.34Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
10.34Single8IEBA1LYA8IEB-GPR156-A1LYA
10.34Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
10.00Single5L7IVismodegib5L7I-SMO-Vismodegib
10.00Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
10.00Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
10.00Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
10.00Single6TP4ACT-4622066TP4-OX1-ACT-462206
10.00Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
10.00Single7UL2SR486927UL2-NTS1-SR48692-Na
10.00Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
10.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
10.00Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
10.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
10.00Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
10.00Consensusgq_nucleotideOrthosteric Ligandgq_p2y
10.00Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
10.00Consensusneurotensin_offOrthosteric Ligandnts1_off
10.00Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
9.68Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
9.68Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
9.52Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
9.52Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
9.52Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
9.52Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
9.52Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
9.52Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
9.52Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
9.52Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
9.52Single9BA0A1AKN9BA0-CB1-A1AKN
9.52Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
9.38Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
9.38Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
9.38Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
9.09Single6ZINSR486926ZIN-NTS1-SR48692
9.09Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
9.09Single8IYXYL-3658IYX-GPR34-YL-365
9.09Single8K2WAMG4878K2W-CXCR3-AMG487
9.09Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
9.09Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
8.82Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
8.70Single4QIMANTA XV4QIM-SMO-ANTA XV
8.70Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
8.70Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
8.70Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
8.70Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
8.70Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
8.70Single7YXAONO-54306087YXA-S1P5-ONO-5430608
8.70Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
8.70Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
8.70Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
8.70Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
8.70Single9IYAONO-97105319IYA-GPR55-ONO-9710531
8.70Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
8.70Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
8.57Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
8.33Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
8.33Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
8.33Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
8.33Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
8.33Single6Z4SSR486926Z4S-NTS1-SR48692
8.33Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
8.33Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
8.33Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
8.33Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
8.33Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
8.33Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
8.33Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
8.33Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
8.33Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
8.33Consensusep_offOrthosteric Ligandep4_off
8.33Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
8.33Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
8.33Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
8.00Single4BV0Neurotensin4BV0-NTS1-Neurotensin
8.00Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
8.00Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
8.00Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
8.00Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
8.00Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
8.00Single9BJKNAM9BJK-μ-Naloxone-NAM
7.69Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
7.69Single4PY02MeSATP4PY0-P2Y12-2MeSATP
7.69Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
7.69Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
7.41Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
7.41Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
7.41Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
7.14Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Single8IEIA1LYA8IEI-GPR156-A1LYA
6.90Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
6.90Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
6.67Single7SHEPI; PE7SHE-GPR158-PI; PE
6.25Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
6.25Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
5.71Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
5.56Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.56Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
5.56Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
5.26Single8IKGQ2B8IKG-CB1-Q2B-Gi1/β1/γ1
5.26Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
5.00Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
5.00Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
5.00Single8JPSCCL78JPS-ACKR1-CCL7
5.00Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
4.76Single4O9RCyclopamine4O9R-SMO-Cyclopamine
4.76Single6LI0C176LI0-GPR52-C17
4.76Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
4.76Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
4.76Single8IKHQ2L8IKH-CB1-Q2L-Gi1/β1/γ1
4.76Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single4K5YCP-3763954K5Y-CRF1-CP-376395
4.55Single4QINSAG1.54QIN-SMO-SAG1.5
4.55Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
4.55Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
4.55Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
4.55Single7WV9ZCZ0117WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
4.55Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
4.55Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
4.55Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
4.35Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
4.35Single7VV6C48/807VV6-MRGPRX2-C48/80
4.35Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
4.35Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
4.35Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
4.17Single4Z9GCP-3763954Z9G-CRF1-CP-376395
4.17Single5T04Neurotensin5T04-NTS1-Neurotensin
4.17Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
4.17Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
4.17Single8GTIBMK-C2058GTI-CRF1-BMK-C205
4.00Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
4.00Single8GTGBMK-I1528GTG-CRF1-BMK-I152
4.00Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
4.00Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
3.70Single7SHEPI; PE7SHE-GPR158-PI; PE
3.70Single8GTMBMK-C2038GTM-CRF1-BMK-C203
3.57Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
3.45Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
3.45Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
3.33Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
3.33Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
3.33Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
3.23Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
3.23Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7

Consensus Members
Id Members
7TRS 7TRS-M4-Acetylcholine-Gi1/β1/γ2
7V6A 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
8E9X 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
7TRK 7TRK-M4-Iperoxo-Gi1/β1/γ2
Net Summary
Imin 2.87
Number of Linked Nodes 892
Number of Links 1099
Number of Hubs 181
Number of Links mediated by Hubs 683
Number of Communities 31
Number of Nodes involved in Communities 250
Number of Links involved in Communities 356
Path Summary
Number Of Nodes in MetaPath 85
Number Of Links MetaPath 84
Number of Shortest Paths 3172939
Length Of Smallest Path 3
Average Path Length 36.4389
Length of Longest Path 61
Minimum Path Strength 0.38625
Average Path Strength 5.91246
Maximum Path Strength 21.5913
Minimum Path Correlation 0.7
Average Path Correlation 0.984989
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.72414
Average % Of Corr. Nodes 31.8023
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 56.1653
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following differences:
Id1st Network2nd Network
m4_off_on_gpm4_on_gpm4_off
This network is also present in following consensuses:
IdComponents
muscarinic_on_gpm2_on_gp
m3_on_gp
m4_on_gp
m1_on_gp



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download m4_on_gp.zip



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You can also  read or  download a guide explaining the meaning of all files and numerical data.