psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:S112	R:R:Y116	5.09	No	No	0	2	3
2	R:R:H115	R:R:R341	5.64	Yes	No	0	4	4
3	R:R:H115	R:R:V342	8.3	Yes	No	4	4	3
4	R:R:H115	R:R:Y346	8.71	Yes	Yes	4	4	6
5	R:R:V118	R:R:Y346	8.83	No	Yes	0	4	6
6	R:R:H127	R:R:N123	7.65	Yes	Yes	2	7	7
7	R:R:N123	R:R:W169	7.91	Yes	Yes	2	7	7
8	R:R:A349	R:R:N123	4.69	No	Yes	0	6	7
9	R:R:E352	R:R:N123	13.15	No	Yes	0	8	7
10	R:R:W169	R:R:Y124	6.75	Yes	No	2	7	6
11	R:R:F170	R:R:Y124	7.22	Yes	No	2	7	6
12	R:R:G126	R:R:I129	5.29	No	No	0	8	5
13	R:R:G126	R:R:S353	3.71	No	No	0	8	8
14	R:R:H127	R:R:N166	6.38	Yes	No	0	7	7
15	R:R:H127	R:R:W169	39.14	Yes	Yes	2	7	7
16	R:R:H127	R:R:S353	8.37	Yes	No	0	7	8
17	R:R:F354	R:R:I129	8.79	Yes	No	0	6	5
18	R:R:F354	R:R:S130	3.96	Yes	No	0	6	9
19	R:R:G356	R:R:S130	3.71	No	No	0	9	9
20	R:R:L131	R:R:N166	12.36	No	No	0	6	7
21	R:R:I159	R:R:L134	4.28	Yes	No	0	7	8
22	R:R:G356	R:R:L134	5.13	No	No	0	9	8
23	R:R:F138	R:R:L142	8.53	Yes	No	0	6	3
24	R:R:F138	R:R:I159	3.77	Yes	Yes	0	6	7
25	R:R:F138	R:R:I163	5.02	Yes	No	0	6	7
26	R:R:F141	R:R:N152	6.04	Yes	No	5	7	8
27	R:R:F141	R:R:H155	9.05	Yes	Yes	5	7	9
28	R:R:F141	R:R:I159	3.77	Yes	Yes	0	7	7
29	R:R:F141	R:R:N367	7.25	Yes	No	0	7	9
30	R:R:N152	R:R:S146	4.47	No	No	0	8	6
31	R:R:C149	R:R:R151	12.54	No	Yes	0	6	8
32	R:R:R151	R:R:Y212	10.29	Yes	No	0	8	7
33	R:R:H155	R:R:N152	6.38	Yes	No	5	9	8
34	R:R:I154	R:R:W205	4.7	No	Yes	0	8	9
35	R:R:E209	R:R:I154	6.83	No	No	0	9	8
36	R:R:F231	R:R:I154	7.54	No	No	0	6	8
37	R:R:E209	R:R:H155	12.31	No	Yes	0	9	9
38	R:R:H155	R:R:L366	7.71	Yes	No	0	9	5
39	R:R:N157	R:R:W205	14.69	No	Yes	1	9	9
40	R:R:N157	R:R:W236	6.78	No	Yes	1	9	9
41	R:R:F162	R:R:L158	4.87	No	No	0	7	8
42	R:R:L158	R:R:M206	7.07	No	No	0	8	9
43	R:R:E209	R:R:L158	5.3	No	No	0	9	8
44	R:R:A161	R:R:W236	3.89	No	Yes	0	8	9
45	R:R:F162	R:R:N202	21.75	No	No	0	7	7
46	R:R:F162	R:R:V359	9.18	No	No	0	7	9
47	R:R:F198	R:R:L164	13.4	No	No	0	6	5
48	R:R:R165	R:R:Y195	17.49	No	Yes	0	8	5
49	R:R:H199	R:R:R165	24.83	No	No	0	5	8
50	R:R:N202	R:R:R165	8.44	No	No	0	7	8
51	R:R:F170	R:R:N166	4.83	Yes	No	0	7	7
52	R:R:T168	R:R:Y195	4.99	No	Yes	0	4	5
53	R:R:F198	R:R:T168	6.49	No	No	0	6	4
54	R:R:F170	R:R:W169	8.02	Yes	Yes	2	7	7
55	R:R:Q173	R:R:W169	13.14	No	Yes	0	7	7
56	R:R:W169	R:R:Y195	5.79	Yes	Yes	0	7	5
57	R:R:V172	R:R:Y195	5.05	No	Yes	0	6	5
58	R:R:T175	R:R:W187	9.7	No	No	0	3	2
59	R:R:H181	R:R:M176	3.94	Yes	No	0	4	6
60	R:R:E179	R:R:S177	8.62	No	No	0	1	4
61	R:R:E179	R:R:P178	6.29	No	No	0	1	2
62	R:R:H181	R:R:K257	18.34	Yes	Yes	0	4	3
63	R:R:C258	R:R:H181	4.42	No	Yes	0	9	4
64	R:R:A260	R:R:H181	4.39	No	Yes	0	6	4
65	R:R:N184	R:R:R189	14.46	No	No	0	6	6
66	R:R:N184	R:R:N255	6.81	No	No	0	6	4
67	R:R:V185	R:R:W187	6.13	No	No	0	3	2
68	R:R:C188	R:R:C258	7.28	No	No	0	9	9
69	R:R:R189	R:R:W259	14.99	No	Yes	0	6	9
70	R:R:N196	R:R:W246	5.65	No	Yes	1	8	8
71	R:R:N196	R:R:Y272	15.12	No	Yes	1	8	7
72	R:R:F198	R:R:Y197	6.19	No	Yes	0	6	8
73	R:R:T201	R:R:Y197	6.24	No	Yes	1	7	8
74	R:R:W236	R:R:Y197	4.82	Yes	Yes	1	9	8
75	R:R:P239	R:R:Y197	5.56	No	Yes	1	9	8
76	R:R:H199	R:R:M276	3.94	No	No	0	5	7
77	R:R:H199	R:R:Y327	10.89	No	No	0	5	8
78	R:R:F204	R:R:V200	5.24	Yes	No	1	5	7
79	R:R:P239	R:R:V200	7.07	No	No	1	9	7
80	R:R:V200	R:R:Y272	3.79	No	Yes	1	7	7
81	R:R:T201	R:R:W236	9.7	No	Yes	1	7	9
82	R:R:F203	R:R:M276	14.93	No	No	0	8	7
83	R:R:F203	R:R:Y327	7.22	No	No	3	8	8
84	R:R:F203	W:W:?4	9.58	No	Yes	3	8	0
85	R:R:F204	R:R:V238	6.55	Yes	No	0	5	3
86	R:R:F204	R:R:P239	4.33	Yes	No	1	5	9
87	R:R:F204	R:R:I242	3.77	Yes	No	0	5	6
88	R:R:F204	R:R:V279	7.87	Yes	No	0	5	7
89	R:R:G235	R:R:W205	8.44	No	Yes	0	8	9
90	R:R:W205	R:R:W236	14.06	Yes	Yes	1	9	9
91	R:R:M206	W:W:?4	6.49	No	Yes	0	9	0
92	R:R:C211	R:R:F207	8.38	No	Yes	0	5	6
93	R:R:F207	R:R:I234	3.77	Yes	No	0	6	5
94	R:R:F207	R:R:V279	3.93	Yes	No	0	6	7
95	R:R:F207	R:R:I282	3.77	Yes	No	0	6	5
96	R:R:G210	R:R:N283	5.09	No	No	3	7	9
97	R:R:G210	W:W:?4	4.49	No	Yes	3	7	0
98	R:R:L222	R:R:Y212	7.03	No	No	0	5	7
99	R:R:H214	R:R:V218	9.69	Yes	No	0	7	6
100	R:R:F286	R:R:H214	18.1	No	Yes	0	7	7
101	R:R:H214	R:R:N289	7.65	Yes	No	0	7	6
102	R:R:H214	R:R:I290	5.3	Yes	Yes	0	7	8
103	R:R:L219	R:R:T215	7.37	No	No	0	4	6
104	R:R:L226	R:R:T215	5.9	No	No	0	4	6
105	R:R:I217	R:R:I290	5.89	No	Yes	6	7	8
106	R:R:A309	R:R:I217	4.87	No	No	0	4	7
107	R:R:I293	R:R:V218	4.61	No	No	0	6	6
108	R:R:L222	R:R:T220	5.9	No	No	0	5	7
109	R:R:M230	R:R:R225	6.2	No	No	0	3	4
110	R:R:M230	R:R:W229	9.31	No	No	0	3	2
111	R:R:F240	R:R:V244	6.55	No	No	0	4	3
112	R:R:I242	R:R:P275	5.08	No	No	0	6	8
113	R:R:K250	R:R:W246	11.6	Yes	Yes	1	6	8
114	R:R:W246	R:R:W259	7.5	Yes	Yes	1	8	9
115	R:R:D269	R:R:W246	5.58	Yes	Yes	1	6	8
116	R:R:I271	R:R:W246	5.87	No	Yes	0	7	8
117	R:R:W246	R:R:Y272	8.68	Yes	Yes	1	8	7
118	R:R:D254	R:R:K250	12.44	No	Yes	1	5	6
119	R:R:K250	R:R:W259	18.57	Yes	Yes	1	6	9
120	R:R:K250	R:R:T268	9.01	Yes	No	0	6	4
121	R:R:L251	R:R:Y252	5.86	No	No	0	2	3
122	R:R:V266	R:R:Y253	7.57	No	No	0	3	6
123	R:R:D254	R:R:E256	3.9	No	No	1	5	3
124	R:R:D254	R:R:R263	4.76	No	No	1	5	3
125	R:R:N255	R:R:W259	5.65	No	Yes	0	4	9
126	R:R:E256	R:R:K257	8.1	No	Yes	0	3	3
127	R:R:E256	R:R:R263	16.28	No	No	1	3	3
128	R:R:G261	R:R:K257	6.97	No	Yes	0	5	3
129	R:R:K262	R:R:Y267	4.78	No	No	0	5	1
130	R:R:G265	R:R:Y267	4.35	No	No	0	6	1
131	R:R:D269	R:R:Y272	4.6	Yes	Yes	1	6	7
132	R:R:D269	R:R:Q273	5.22	Yes	No	1	6	7
133	R:R:Q273	R:R:Y272	11.27	No	Yes	1	7	7
134	R:R:G274	R:R:P275	4.06	No	No	0	3	8
135	R:R:I282	R:R:L278	5.71	No	No	0	5	3
136	R:R:L280	W:W:?4	8.17	No	Yes	0	6	0
137	R:R:F286	R:R:I282	5.02	No	No	0	7	5
138	R:R:N283	W:W:?4	33.32	No	Yes	3	9	0
139	R:R:F284	R:R:L320	6.09	No	No	0	4	7
140	R:R:L287	W:W:?4	9.08	No	Yes	0	7	0
141	R:R:I290	R:R:L294	4.28	Yes	No	0	8	7
142	R:R:I293	R:R:R292	3.76	No	No	0	6	6
143	R:R:L294	R:R:V313	4.47	No	No	0	7	5
144	R:R:K297	R:R:T296	6.01	No	No	0	8	5
145	R:R:L298	R:R:S301	6.01	No	No	0	6	4
146	R:R:S301	R:R:T306	4.8	No	Yes	0	4	5
147	R:R:T303	R:R:T306	10.99	No	Yes	0	4	5
148	R:R:I307	R:R:K311	4.36	No	No	0	5	7
149	R:R:E369	R:R:Q308	7.65	No	No	0	8	5
150	R:R:T316	W:W:?4	8.7	No	Yes	0	7	0
151	R:R:L319	R:R:L323	11.07	No	No	0	9	8
152	R:R:F362	R:R:L319	8.53	No	No	0	8	9
153	R:R:L320	W:W:?4	7.26	No	Yes	0	7	0
154	R:R:F358	R:R:L322	17.05	No	No	0	6	8
155	R:R:L323	R:R:Q355	3.99	No	No	0	8	9
156	R:R:L323	W:W:?4	10.89	No	Yes	0	8	0
157	R:R:I325	R:R:L329	4.28	No	No	0	6	6
158	R:R:N348	R:R:T326	4.39	No	No	0	8	8
159	R:R:Y327	W:W:?4	3.84	No	Yes	3	8	0
160	R:R:F344	R:R:L329	8.53	No	No	0	6	6
161	R:R:P334	R:R:R341	4.32	Yes	No	0	5	4
162	R:R:E336	R:R:E338	10.15	No	No	7	3	3
163	R:R:E336	R:R:S340	5.75	No	No	7	3	2
164	R:R:D337	R:R:R341	9.53	No	No	0	3	4
165	R:R:E338	R:R:S340	5.75	No	No	7	3	2
166	R:R:V342	R:R:Y346	7.57	No	Yes	4	3	6
167	R:R:F344	R:R:I345	3.77	No	No	0	6	7
168	R:R:F347	R:R:L351	6.09	No	No	0	5	5
169	R:R:E352	R:R:N348	3.94	No	No	0	8	8
170	R:R:F354	R:R:F357	11.79	Yes	No	0	6	5
171	R:R:F354	R:R:F358	5.36	Yes	No	0	6	6
172	R:R:F357	R:R:S360	3.96	No	No	0	5	8
173	R:R:F357	R:R:V361	5.24	No	No	0	5	5
174	R:R:F362	R:R:L366	6.09	No	No	0	8	5
175	R:R:F350	R:R:L351	3.65	No	No	0	5	5
176	R:R:I243	R:R:Y197	3.63	No	Yes	0	7	8
177	R:R:I345	R:R:Y346	3.63	No	Yes	0	7	6
178	R:R:A133	R:R:S360	3.42	No	No	0	6	8
179	R:R:A144	R:R:S146	3.42	No	No	0	6	6
180	R:R:C188	R:R:V180	3.42	No	No	0	9	2
181	R:R:C188	R:R:V185	3.42	No	No	0	9	3
182	R:R:A260	R:R:T192	3.36	No	No	0	6	7
183	R:R:L320	R:R:P321	3.28	No	No	0	7	7
184	R:R:S368	R:R:S372	3.26	No	No	0	4	4
185	R:R:A349	R:R:I122	3.25	No	No	0	6	7
186	R:R:A363	R:R:I159	3.25	No	Yes	0	8	7
187	R:R:S177	R:R:V180	3.23	No	No	0	4	2
188	R:R:S183	R:R:V180	3.23	No	No	0	2	2
189	R:R:S183	R:R:V185	3.23	No	No	0	2	3
190	R:R:F350	R:R:F354	3.22	No	Yes	0	5	6
191	R:R:V171	R:R:V191	3.21	No	No	0	4	5
192	R:R:R145	R:R:R148	3.2	No	No	0	6	7
193	R:R:F231	R:R:G208	3.01	No	No	0	6	7
194	R:R:G186	R:R:R189	3	No	No	0	2	6
195	R:R:R227	R:R:W229	3	No	No	0	4	2
196	R:R:L140	R:R:V136	2.98	No	No	0	8	5
197	R:R:L317	R:R:V313	2.98	No	No	0	5	5
198	R:R:F240	R:R:P241	2.89	No	No	0	4	4
199	R:R:P264	R:R:R263	2.88	No	No	0	5	3
200	R:R:I163	R:R:L135	2.85	No	No	0	7	3
201	R:R:I147	R:R:L142	2.85	No	No	0	7	3
202	R:R:I217	R:R:L213	2.85	No	No	6	7	8
203	R:R:I290	R:R:L213	2.85	Yes	No	6	8	8
204	R:R:I293	R:R:L298	2.85	No	No	0	6	6
205	R:R:I325	R:R:L351	2.85	No	No	0	6	5
206	R:R:E338	R:R:V339	2.85	No	No	0	3	1
207	R:R:E305	R:R:T220	2.82	No	No	0	4	7
208	R:R:C128	R:R:F170	2.79	No	Yes	0	6	7
209	R:R:H117	R:R:V114	2.77	No	No	0	2	1
210	R:R:A160	R:R:F138	2.77	No	Yes	0	3	6
211	R:R:D269	R:R:K262	2.77	Yes	No	0	6	5
212	R:R:A315	R:R:F362	2.77	No	No	0	8	8
213	R:R:A315	R:R:F365	2.77	No	No	0	8	6
214	R:R:L251	R:R:N255	2.75	No	No	0	2	4
215	R:R:K257	R:R:Q182	2.71	Yes	No	0	3	2
216	R:R:L174	R:R:Q173	2.66	No	No	0	2	7
217	R:R:E369	R:R:L366	2.65	No	No	0	8	5
218	R:R:C233	R:R:W229	2.61	No	No	0	3	2
219	R:R:A247	R:R:W259	2.59	No	Yes	0	5	9
220	R:R:H214	R:R:L219	2.57	Yes	No	0	7	4
221	R:R:E305	R:R:Q308	2.55	No	No	0	4	5
222	R:R:V191	R:R:W187	2.45	No	No	0	5	2
223	R:R:L150	R:R:R151	2.43	No	Yes	0	6	8
224	R:R:I232	R:R:W205	2.35	No	Yes	0	4	9
225	R:R:Q273	R:R:Y270	2.25	No	No	0	7	7
226	R:R:G324	W:W:?4	2.24	No	Yes	0	9	0
227	R:R:H115	R:R:Y116	2.18	Yes	No	0	4	3
228	R:R:G335	R:R:P334	2.03	No	Yes	0	5	5
229	R:R:Y252	R:R:Y253	1.99	No	No	0	3	6
230	R:R:G249	R:R:T268	1.82	No	No	0	4	4
231	R:R:A137	R:R:C364	1.81	No	No	0	8	8
232	R:R:P334	R:R:S340	1.78	Yes	No	0	5	2
233	R:R:G249	R:R:I248	1.76	No	No	0	4	4
234	R:R:G126	R:R:L125	1.71	No	No	0	8	6
235	R:R:A137	R:R:S360	1.71	No	No	0	8	8
236	R:R:A216	R:R:T215	1.68	No	No	0	7	6
237	R:R:N333	R:R:P334	1.63	No	Yes	0	6	5
238	R:R:A228	R:R:I153	1.62	No	No	0	5	6
239	R:R:A193	R:R:I243	1.62	No	No	0	5	7
240	R:R:A245	R:R:I271	1.62	No	No	0	5	7
241	R:R:V132	R:R:V136	1.6	No	No	0	3	5
242	R:R:V291	R:R:V313	1.6	No	No	0	6	5
243	R:R:V339	R:R:V343	1.6	No	No	0	1	3
244	R:R:A228	R:R:L150	1.58	No	No	0	5	6
245	R:R:A312	R:R:L213	1.58	No	No	0	7	8
246	R:R:M295	R:R:V291	1.52	No	No	0	4	6
247	R:R:I307	R:R:T306	1.52	No	Yes	0	5	5
248	R:R:E305	R:R:S304	1.44	No	No	0	4	3
249	R:R:K311	R:R:K314	1.44	No	No	0	7	8
250	R:R:E369	R:R:V370	1.43	No	No	0	8	9
251	R:R:L329	R:R:M328	1.41	No	No	0	6	4
252	R:R:A156	R:R:F141	1.39	No	Yes	0	5	7
253	R:R:A300	R:R:R299	1.38	No	No	0	5	5
254	R:R:H117	R:R:K113	1.31	No	No	0	2	1
255	R:R:F288	R:R:V291	1.31	No	No	0	4	6
256	R:R:F331	R:R:V332	1.31	No	No	0	5	5
257	R:R:R151	R:R:T223	1.29	Yes	No	0	8	5
258	R:R:R292	R:R:T296	1.29	No	No	0	6	5
259	R:R:R310	R:R:T306	1.29	No	Yes	0	5	5
260	R:R:L226	R:R:R225	1.21	No	No	0	4	4
261	R:R:Q308	R:R:R371	1.17	No	No	0	5	7
262	R:R:F240	R:R:Y197	1.03	No	Yes	0	4	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:H115	6.2075	4	4	4
2	R:R:N123	8.35	4	2	7
3	R:R:H127	15.385	4	2	7
4	R:R:F138	5.0225	4	0	6
5	R:R:F141	5.5	5	5	7
6	R:R:R151	6.6375	4	0	8
7	R:R:H155	8.8625	4	5	9
8	R:R:I159	3.7675	4	0	7
9	R:R:W169	13.4583	6	2	7
10	R:R:F170	5.715	4	2	7
11	R:R:H181	7.7725	4	0	4
12	R:R:Y195	8.33	4	0	5
13	R:R:Y197	4.57833	6	1	8
14	R:R:F204	5.552	5	1	5
15	R:R:W205	8.848	5	1	9
16	R:R:F207	4.9625	4	0	6
17	R:R:H214	8.662	5	0	7
18	R:R:W236	7.85	5	1	9
19	R:R:W246	7.48	6	1	8
20	R:R:K250	12.905	4	1	6
21	R:R:K257	9.03	4	0	3
22	R:R:W259	9.86	5	1	9
23	R:R:D269	4.5425	4	1	6
24	R:R:Y272	8.692	5	1	7
25	R:R:I290	4.58	4	6	8
26	R:R:T306	4.65	4	0	5
27	R:R:P334	2.44	4	0	5
28	R:R:Y346	7.185	4	4	6
29	R:R:F354	6.624	5	0	6
30	W:W:?4	9.46	11	3	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H115	R:R:R341	16.0195	5.64	Yes	No	0	4	4
2	R:R:H115	R:R:Y346	20.3769	8.71	Yes	Yes	4	4	6
3	R:R:H127	R:R:S353	39.3036	8.37	Yes	No	0	7	8
4	R:R:G126	R:R:S353	38.5284	3.71	No	No	0	8	8
5	R:R:G126	R:R:I129	37.2987	5.29	No	No	0	8	5
6	R:R:F354	R:R:I129	36.7573	8.79	Yes	No	0	6	5
7	R:R:F350	R:R:F354	35.9086	3.22	No	Yes	0	5	6
8	R:R:F350	R:R:L351	34.5519	3.65	No	No	0	5	5
9	R:R:I325	R:R:L351	31.765	2.85	No	No	0	6	5
10	R:R:I325	R:R:L329	30.4284	4.28	No	No	0	6	6
11	R:R:F344	R:R:L329	27.5814	8.53	No	No	0	6	6
12	R:R:F344	R:R:I345	26.2514	3.77	No	No	0	6	7
13	R:R:I345	R:R:Y346	24.8012	3.63	No	Yes	0	7	6
14	R:R:H127	R:R:W169	39.2301	39.14	Yes	Yes	2	7	7
15	R:R:F354	R:R:S130	17.2225	3.96	Yes	No	0	6	9
16	R:R:G356	R:R:S130	17.2425	3.71	No	No	0	9	9
17	R:R:I159	R:R:L134	18.8198	4.28	Yes	No	0	7	8
18	R:R:G356	R:R:L134	18.0111	5.13	No	No	0	9	8
19	R:R:F141	R:R:I159	25.269	3.77	Yes	Yes	0	7	7
20	R:R:F141	R:R:H155	26.9197	9.05	Yes	Yes	5	7	9
21	R:R:L222	R:R:Y212	10.7198	7.03	No	No	0	5	7
22	R:R:L222	R:R:T220	12.2034	5.9	No	No	0	5	7
23	R:R:E305	R:R:T220	13.5802	2.82	No	No	0	4	7
24	R:R:E305	R:R:Q308	16.4873	2.55	No	No	0	4	5
25	R:R:E369	R:R:Q308	19.3344	7.65	No	No	0	8	5
26	R:R:E369	R:R:L366	22.1279	2.65	No	No	0	8	5
27	R:R:H155	R:R:L366	26.5722	7.71	Yes	No	0	9	5
28	R:R:E209	R:R:I154	45.6526	6.83	No	No	0	9	8
29	R:R:E209	R:R:H155	42.1573	12.31	No	Yes	0	9	9
30	R:R:I154	R:R:W205	45.9935	4.7	No	Yes	0	8	9
31	R:R:W169	R:R:Y195	53.7392	5.79	Yes	Yes	0	7	5
32	R:R:T168	R:R:Y195	58.6179	4.99	No	Yes	0	4	5
33	R:R:F198	R:R:T168	58.8184	6.49	No	No	0	6	4
34	R:R:F198	R:R:Y197	59.7541	6.19	No	Yes	0	6	8
35	R:R:W236	R:R:Y197	47.5373	4.82	Yes	Yes	1	9	8
36	R:R:W205	R:R:W236	46.1004	14.06	Yes	Yes	1	9	9
37	R:R:E209	R:R:L158	23.3309	5.3	No	No	0	9	8
38	R:R:R165	R:R:Y195	27.9824	17.49	No	Yes	0	8	5
39	R:R:L158	R:R:M206	15.2042	7.07	No	No	0	8	9
40	R:R:H199	R:R:R165	19.3945	24.83	No	No	0	5	8
41	R:R:P239	R:R:Y197	100	5.56	No	Yes	1	9	8
42	R:R:P239	R:R:V200	51.9281	7.07	No	No	1	9	7
43	R:R:V200	R:R:Y272	66.8917	3.79	No	Yes	1	7	7
44	R:R:W246	R:R:Y272	56.9872	8.68	Yes	Yes	1	8	7
45	R:R:K250	R:R:W246	40.0388	11.6	Yes	Yes	1	6	8
46	R:R:D254	R:R:K250	36.7239	12.44	No	Yes	1	5	6
47	R:R:D254	R:R:E256	32.2729	3.9	No	No	1	5	3
48	R:R:E256	R:R:K257	31.1368	8.1	No	Yes	0	3	3
49	R:R:H181	R:R:K257	26.8061	18.34	Yes	Yes	0	4	3
50	R:R:C258	R:R:H181	20.8447	4.42	No	Yes	0	9	4
51	R:R:C188	R:R:C258	19.321	7.28	No	No	0	9	9
52	R:R:W246	R:R:W259	15.4314	7.5	Yes	Yes	1	8	9
53	R:R:H199	R:R:Y327	16.1398	10.89	No	No	0	5	8
54	R:R:F204	R:R:P239	47.7043	4.33	Yes	No	1	5	9
55	R:R:Y327	W:W:?4	14.3487	3.84	No	Yes	3	8	0
56	R:R:M206	W:W:?4	14.068	6.49	No	Yes	0	9	0
57	R:R:F204	R:R:V279	58.2303	7.87	Yes	No	0	5	7
58	R:R:F207	R:R:V279	57.1075	3.93	Yes	No	0	6	7
59	R:R:F207	R:R:I282	53.659	3.77	Yes	No	0	6	5
60	R:R:F286	R:R:H214	50.0902	18.1	No	Yes	0	7	7
61	R:R:F286	R:R:I282	51.2932	5.02	No	No	0	7	5
62	R:R:H214	R:R:V218	20.671	9.69	Yes	No	0	7	6
63	R:R:H214	R:R:I290	17.296	5.3	Yes	Yes	0	7	8
64	R:R:H214	R:R:L219	14.4222	2.57	Yes	No	0	7	4
65	R:R:L219	R:R:T215	12.8584	7.37	No	No	0	4	6
66	R:R:I293	R:R:V218	19.1606	4.61	No	No	0	6	6
67	R:R:I293	R:R:L298	12.9854	2.85	No	No	0	6	6
68	R:R:L298	R:R:S301	11.4081	6.01	No	No	0	6	4
69	R:R:P334	R:R:R341	12.9319	4.32	Yes	No	0	5	4
70	R:R:F204	R:R:V200	15.9594	5.24	Yes	No	1	5	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L158	R:R:M206	7.07	0	No	No	8	9	2	1
R:R:H199	R:R:M276	3.94	0	No	No	5	7	2	2
R:R:H199	R:R:Y327	10.89	0	No	No	5	8	2	1
R:R:F203	R:R:M276	14.93	3	No	No	8	7	1	2
R:R:F203	R:R:Y327	7.22	3	No	No	8	8	1	1
R:R:F203	W:W:?4	9.58	3	No	Yes	8	0	1	0
R:R:M206	W:W:?4	6.49	0	No	Yes	9	0	1	0
R:R:G210	R:R:N283	5.09	3	No	No	7	9	1	1
R:R:G210	W:W:?4	4.49	3	No	Yes	7	0	1	0
R:R:L280	W:W:?4	8.17	0	No	Yes	6	0	1	0
R:R:N283	W:W:?4	33.32	3	No	Yes	9	0	1	0
R:R:F284	R:R:L320	6.09	0	No	No	4	7	2	1
R:R:L287	W:W:?4	9.08	0	No	Yes	7	0	1	0
R:R:T316	W:W:?4	8.7	0	No	Yes	7	0	1	0
R:R:L319	R:R:L323	11.07	0	No	No	9	8	2	1
R:R:L320	W:W:?4	7.26	0	No	Yes	7	0	1	0
R:R:L323	R:R:Q355	3.99	0	No	No	8	9	1	2
R:R:L323	W:W:?4	10.89	0	No	Yes	8	0	1	0
R:R:Y327	W:W:?4	3.84	3	No	Yes	8	0	1	0
R:R:L320	R:R:P321	3.28	0	No	No	7	7	1	2
R:R:G324	W:W:?4	2.24	0	No	Yes	9	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
91.67	Single	8GTG	BMK-I152	8GTG-CRF₁-BMK-I152
83.33	Single	8GTI	BMK-C205	8GTI-CRF₁-BMK-C205
81.82	Single	4K5Y	CP-376395	4K5Y-CRF₁-CP-376395
66.67	Single	8GTM	BMK-C203	8GTM-CRF₁-BMK-C203
35.71	Single	8HNN	SCH546738	8HNN-CXCR3-SCH546738
33.33	Single	8J20	AR420626	8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
21.05	Single	7VOE	Aripiprazole	7VOE-5-HT_2A-Aripiprazole
20.00	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
20.00	Single	8TAO	CDPPB	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
20.00	Single	8XQP	Aristolochic acid A	8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
17.65	Single	8XQN	Aristolochic acid A	8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
17.65	Single	8XQR	Flufenamic acid	8XQR-TAS2R14-Flufenamic acid-Gt3/β1/γ1
17.65	Single	8XQT	Cholesterol	8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
17.39	Single	6XBJ	Cholesterol	6XBJ-SMO-Cholesterol-Gi1/β1/γ2
16.67	Single	7VOD	Cariprazine	7VOD-5-HT_2A-Cariprazine
16.67	Single	8FN0	PubChem 118610427	8FN0-NTS₁-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
16.67	Single	8RQL	Flufenamic acid	8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
16.67	Single	8XQO	Aristolochic acid A	8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
16.67	Single	8XQS	Flufenamic acid	8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
15.79	Single	6FKD	PubChem 137349183	6FKD-Rhodopsin-PubChem 137349183
15.79	Single	7WC8	Lumateperone	7WC8-5-HT_2A-Lumateperone
15.79	Single	8JT8	(R)-IHCH-7179	8JT8-5-HT_2A-(R)-IHCH-7179
15.79	Single	8XQL	Aristolochic acid A	8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
14.29	Single	8X0F	VU0424465	8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
13.64	Single	6A93	Risperidone	6A93-5-HT_2A-Risperidone
13.64	Single	8JD3	HZR; PEF	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
13.64	Single	8TB7	PubChem 168510218	8TB7-GPR61-PubChem 168510218
13.33	Single	8ZPN	Cholesterol	8ZPN-CXCR4-AMD3100-Cholesterol
13.04	Single	7MTS	ADX55164	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
12.50	Single	8ZPL	Cholesterol	8ZPL-CXCR4-HF51116-Cholesterol
12.50	Single	8ZPM	Cholesterol	8ZPM-CXCR4-AMD070-Cholesterol
11.76	Single	7V68	Iperoxo	7V68-M₄-Iperoxo-PubChem 57664406-Gi1/β1/γ2
11.76	Single	8X2K	Oleic monoethanolamide	8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
11.11	Single	7EJX	(1R;2R)-2-PCCA	7EJX-GPR88-(1R;2R)-2-PCCA-Gi1/β1/γ2
11.11	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
11.11	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
11.11	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
11.11	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
11.11	Single	7VVO	PTH	7VVO-PTH1-PTH-Gs/β1/γ2
11.11	Single	8A6C	All-trans-Retinal	8A6C-Rhodopsin-All-trans-Retinal
11.11	Single	8A6D	All-trans-Retinal	8A6D-Rhodopsin-All-trans-Retinal
11.11	Single	8A6E	All-trans-Retinal	8A6E-Rhodopsin-All-trans-Retinal
11.11	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
11.11	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
10.53	Single	3OAX	11-cis-Retinal	3OAX-Rhodopsin-11-cis-Retinal
10.53	Single	6A94	Zotepine	6A94-5-HT_2A-Zotepine
10.53	Single	6FFI	MMPEP	6FFI-mGlu₅-MMPEP
10.53	Single	6FKA	PubChem 132473037	6FKA-Rhodopsin-PubChem 132473037
10.53	Single	7ZBC	11-cis-Retinal	7ZBC-Rhodopsin-11-cis-Retinal
10.53	Single	7ZBE	11-cis-Retinal	7ZBE-Rhodopsin-11-cis-Retinal
10.53	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
10.53	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53	Single	9ASB	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53	Single	9AVG	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
10.53	Consensus	5ht2a_off	Orthosteric Ligand	6A94-5-HT_2A-Zotepine 6A93-5-HT_2A-Risperidone 7VOD-5-HT_2A-Cariprazine 7WC8-5-HT_2A-Lumateperone 8JT8-5-HT_2A-(R)-IHCH-7179
10.00	Single	1HZX	11-cis-Retinal	1HZX-Rhodopsin-11-cis-Retinal
10.00	Single	6FFH	Fenobam	6FFH-mGlu₅-Fenobam
10.00	Single	7F83	PF-05190457	7F83-Ghrelin-PF-05190457
10.00	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
10.00	Single	7RBT	PubChem 163183774	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
10.00	Single	8JPC	PubChem 118610427; GDP; Mg	8JPC-NTS₁-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
10.00	Single	8JPF	PubChem 118610427	8JPF-NTS₁-Neurotensin-PubChem 118610427
10.00	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
10.00	Single	8X63	Mepyramine	8X63-H₁-Mepyramine
10.00	Single	8X64	Desloratadine	8X64-H₁-Desloratadine
10.00	Consensus	histamine_off	Orthosteric Ligand	h1_off
9.52	Single	6LUQ	Haloperidol	6LUQ-D₂-Haloperidol
9.52	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
9.52	Single	7E9G	JNJ-40411813	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
9.52	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
9.52	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
9.52	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
9.52	Single	7TRK	Iperoxo	7TRK-M₄-Iperoxo-Gi1/β1/γ2
9.52	Single	8E9Z	Iperoxo	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52	Single	8GW8	KHF	8GW8-PTH1-KHF-Gs/β1/γ2
9.52	Single	8J18	(3R)-3-Hydroxydodecanoic acid	8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
9.52	Single	8T6J	CDPPB	8T6J-mGlu5; mGlu5-CDPPB
9.52	Single	8T6J	CDPPB	8T6J-mGlu5; mGlu5-CDPPB
9.52	Single	8X0B	VU0424465	8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
9.52	Single	8X0C	VU0424465	8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
9.52	Single	8X0C	VU0424465	8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
9.52	Single	8X0D	VU0424465	8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
9.52	Single	8X0D	VU0424465	8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
9.52	Single	8YNS	SNAP-94847	8YNS-MCH1-SNAP-94847
9.52	Single	8ZMF	A1L10	8ZMF-5-HT_2C-A1L10
9.52	Single	8ZRK	GSK-1292263	8ZRK-GPR119-GSK-1292263-Gs/β1/γ2
9.52	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
9.52	Consensus	gq_muscarinic	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
9.52	Consensus	h1_off	Orthosteric Ligand	8X63-H₁-Mepyramine 3RZE-H₁-Cidoxepin 8X5Y-H₁-Astemizole
9.52	Consensus	m1_on	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
9.09	Single	5V54	Methiothepin	5V54-5-HT_1B-Methiothepin
9.09	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
9.09	Single	6OIJ	Iperoxo	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
9.09	Single	7EW4	CYM5541	7EW4-S1P₃-CYM5541-Gi1/β1/γ2
9.09	Single	7EW7	SEW2871	7EW7-S1P₁-SEW2871-Gi1/β1/γ2
9.09	Single	7P2L	4YI	7P2L-mGlu₅-4YI
9.09	Single	7TRQ	Iperoxo	7TRQ-M₄-Iperoxo-VU0467154-Gi1/β1/γ2
9.09	Single	8EA0	Iperoxo	8EA0-M₃-Iperoxo
9.09	Single	8X0B	VU0424465	8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
9.09	Single	8YNT	SNAP-94847	8YNT-MCH1-SNAP-94847
9.09	Single	8ZR5	Firuglipel	8ZR5-GPR119-Firuglipel-Gs/β1/γ2
9.09	Consensus	5ht1_off	Orthosteric Ligand	5ht1b_off
9.09	Consensus	5ht1b_off	Orthosteric Ligand	5V54-5-HT_1B-Methiothepin
9.09	Consensus	5ht_off	Orthosteric Ligand	5ht2_off 5ht1_off
9.09	Consensus	m1_on_gp	Orthosteric Ligand	6OIJ-M₁-Iperoxo-chim(NtGi1L-G11)/β1/γ2
8.70	Single	6CM4	Risperidone	6CM4-D₂-Risperidone
8.70	Single	6XBL	Cholesterol	6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
8.70	Single	7DFP	Spiperone	7DFP-D₂-Spiperone
8.70	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/β1/γ2
8.70	Single	7MTR	ADX55164	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
8.70	Single	7WCM	MBX-2982	7WCM-GPR119-MBX-2982-Gs/β1/γ2
8.70	Single	7WCN	AR231453	7WCN-GPR119-AR231453-Gs/β1/γ2
8.70	Single	7XZ5	Lysophosphatidylcholine	7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
8.70	Single	8JR9	PCO371	8JR9-PTH1-PCO371-chim(NtGi1-Gs)/β1/γ2
8.70	Single	8VHF	MBX-2982	8VHF-GPR119-MBX-2982-Gs/β1/γ2
8.33	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
8.33	Single	5CGD	HTL14242	5CGD-mGlu₅-HTL14242
8.33	Single	6BQH	Ritanserin	6BQH-5-HT_2C-Ritanserin
8.33	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2
8.33	Single	7SK7	CCX662	7SK7-ACKR3-CXCL12-CCX662
8.33	Single	7XZ6	APD668	7XZ6-GPR119-APD668-Gs/β1/γ2
8.33	Consensus	5ht2c_off	Orthosteric Ligand	6BQH-5-HT_2C-Ritanserin
8.33	Consensus	d2_off	Orthosteric Ligand	6CM4-D₂-Risperidone 6LUQ-D₂-Haloperidol 7DFP-D₂-Spiperone
8.00	Single	8X5Y	Astemizole	8X5Y-H₁-Astemizole
8.00	Consensus	s1p_on	Orthosteric Ligand	s1p1_on s1p3_on s1p5_on
8.00	Consensus	s1p_on_gp	Orthosteric Ligand	s1p1_on_gp s1p3_on_gp s1p5_on_gp
7.69	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/β1/γ2
7.41	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
7.41	Consensus	formylpeptide_on_gp	Orthosteric Ligand	fpr2-alx_on_gp fpr1-alx_on_gp
7.14	Single	4A4M	All-trans-Retinal	4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
7.14	Single	5EN0	All-trans-Retinal	5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
7.14	Single	7T6T	fMLFII	7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
7.14	Consensus	fpr2-alx_on	Orthosteric Ligand	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
6.90	Single	7WUI	IP15	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
6.90	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
6.90	Consensus	fpr2-alx_on_gp	Orthosteric Ligand	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
6.90	Consensus	gi_formylpeptide	Orthosteric Ligand	7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
6.67	Single	3PXO	All-trans-Retinal	3PXO-Rhodopsin-All-trans-Retinal
6.67	Single	5DYS	All-trans-Retinal	5DYS-Rhodopsin-All-trans-Retinal
6.67	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
6.67	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
6.25	Single	2HPY	All-trans-Retinal	2HPY-Rhodopsin-All-trans-Retinal
6.25	Single	6OY9	All-trans-Retinal	6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
6.25	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
6.25	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
6.25	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/β1/γ2
6.25	Single	7WVY	Amyloid-Beta42	7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
6.25	Single	8WC5	Tetramethylammonium Ion	8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
6.25	Consensus	opsins_on	Orthosteric Ligand	rhodopsin_on opsin1lw_on
6.25	Consensus	sensory_on	Orthosteric Ligand	opsins_on
6.06	Single	6PB1	Urocortin	6PB1-CRF₂-Urocortin-chim(NtGi1-Gs)/β1/γ2
6.06	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
6.06	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
6.06	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/β1/γ2
5.88	Single	2J4Y	11-cis-Retinal	2J4Y-Rhodopsin-11-cis-Retinal
5.88	Single	2ZIY	11-cis-Retinal	2ZIY-Rhodopsin-11-cis-Retinal
5.88	Single	3C9M	11-cis-Retinal	3C9M-Rhodopsin-11-cis-Retinal
5.88	Single	3PQR	All-trans-Retinal	3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
5.88	Single	5WKT	Octyl-Beta-D-Glucopyranoside	5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
5.88	Single	6PB0	Urocortin	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/β1/γ2
5.88	Single	7D77	Hydrocortisone	7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
5.88	Single	7MT8	All-trans-Retinal	7MT8-Rhodopsin-All-trans-Retinal-GRK1
5.88	Single	7MT9	All-trans-Retinal	7MT9-Rhodopsin-All-trans-Retinal-GRK1
5.88	Single	7MTA	All-trans-Retinal	7MTA-Rhodopsin-All-trans-Retinal-GRK1
5.88	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
5.88	Single	8IU2	Retinal	8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.88	Single	8POK	Histamine	8POK-H₂-Histamine-Gs/β1/γ2
5.88	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.88	Single	9C1P	Ca; Tryptophan; '6218; PO4	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.88	Single	9C1P	Ca; Tryptophan; '6218; PO4	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.88	Consensus	gi_opsins	Orthosteric Ligand	8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.88	Consensus	gi_sensory	Orthosteric Ligand	gi_opsins
5.88	Consensus	h2_on_gp	Orthosteric Ligand	8POK-H₂-Histamine-Gs/β1/γ2
5.88	Consensus	opsin1lw_on	Orthosteric Ligand	8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.88	Consensus	opsin1lw_on_gp	Orthosteric Ligand	8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.88	Consensus	opsins_on_gp	Orthosteric Ligand	rhodopsin_on_gp opsin1lw_on_gp
5.88	Consensus	rhodopsin_on	Orthosteric Ligand	6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.88	Consensus	sensory_on_gp	Orthosteric Ligand	opsins_on_gp
5.71	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
5.71	Single	8F2A	Pramlintide Analogue San385	8F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
5.71	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
5.56	Single	1L9H	11-cis-Retinal	1L9H-Rhodopsin-11-cis-Retinal
5.56	Single	1U19	11-cis-Retinal	1U19-Rhodopsin-11-cis-Retinal
5.56	Single	2G87	All-trans-Retinal	2G87-Rhodopsin-All-trans-Retinal
5.56	Single	2I35	11-cis-Retinal	2I35-Rhodopsin-11-cis-Retinal
5.56	Single	3AYM	All-trans-Retinal	3AYM-Rhodopsin-All-trans-Retinal
5.56	Single	5TE5	20-Methanoretinal	5TE5-Rhodopsin-20-Methanoretinal
5.56	Single	6FK6	PubChem 132473033	6FK6-Rhodopsin-PubChem 132473033
5.56	Single	6I9K	9-cis-Retinal	6I9K-Rhodopsin-9-cis-Retinal
5.56	Single	6PH7	Nerol	6PH7-Rhodopsin-Nerol-Gt(CT)
5.56	Single	7CA3	rac-BHFF	7CA3-GABA_B1, GABA_B2-rac-BHFF
5.56	Single	7D76	Beclomethasone	7D76-ADGRG3-Beclomethasone-Go/β1/γ2
5.56	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.56	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.56	Single	7XKF	Beta-Hydroxyandrosterone	7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.56	Single	7YFC	Histamine	7YFC-H₄-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56	Single	7YFD	Imetit	7YFD-H₄-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56	Single	8HN8	Histamine	8HN8-H₄-Histamine-Gi1/β1/γ2
5.56	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.56	Single	8W89	PEA	8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
5.56	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56	Single	8Y0N	VUF11418	8Y0N-CXCR3-VUF11418-Go1/β1/γ2
5.56	Single	8ZSV	RO5263397	8ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
5.56	Single	9EPR	Retinal	9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
5.56	Consensus	h4_on	Orthosteric Ligand	8HN8-H₄-Histamine-Gi1/β1/γ2 8HOC-H₄-Imetit-Gi1/β1/γ2 8JXV-H₄-Clozapine-Gi1/β1/γ2 8JXW-H₄-VUF6884-Gi1/β1/γ2 8JXX-H₄-Clobenpropit-Gi1/β1/γ2
5.41	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/β1/γ2
5.41	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
5.26	Single	1GZM	11-cis-Retinal	1GZM-Rhodopsin-11-cis-Retinal
5.26	Single	2PED	9-cis-Retinal	2PED-Rhodopsin-9-cis-Retinal
5.26	Single	2Z73	11-cis-Retinal	2Z73-Rhodopsin-11-cis-Retinal
5.26	Single	3AYN	9-cis-Retinal	3AYN-Rhodopsin-9-cis-Retinal
5.26	Single	3C9L	11-cis-Retinal	3C9L-Rhodopsin-11-cis-Retinal
5.26	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
5.26	Single	3VG9	ZM-241385	3VG9-A_2A-ZM-241385-Antibody
5.26	Single	6B73	MP1104	6B73-κ-MP1104
5.26	Single	6C1Q	NDT9513727	6C1Q-C5a₁-PMX53-NDT9513727
5.26	Single	6FKB	PubChem 132473038	6FKB-Rhodopsin-PubChem 132473038
5.26	Single	6KUY	PubChem 145704643	6KUY-α_2a-PubChem 145704643
5.26	Single	6NWE	Octyl-Beta-D-Glucopyranoside	6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
5.26	Single	6OYA	All-trans-Retinal	6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.26	Single	6TQ6	PubChem 145714283	6TQ6-OX₁-PubChem 145714283
5.26	Single	7C7Q	PubChem 7023848	7C7Q-GABA_B1, GABA_B2-Baclofen-PubChem 7023848
5.26	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.26	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.26	Single	7T6S	PubChem 24776341	7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
5.26	Single	7T8X	Acetylcholine	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2
5.26	Single	7T90	Acetylcholine	7T90-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2
5.26	Single	7T96	Acetylcholine	7T96-M₂-Acetylcholine-LY2119620-Go/β1/γ2
5.26	Single	7YM8	Oxymetazoline	7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
5.26	Single	8DU3	PubChem 105526064	8DU3-A_2A-PubChem 105526064
5.26	Single	8HOC	Imetit	8HOC-H₄-Imetit-Gi1/β1/γ2
5.26	Single	8U8F	Palmitic Acid	8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
5.26	Single	8WC3	SEP-363856	8WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
5.26	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.26	Single	8Y0H	VUF11418	8Y0H-CXCR3-VUF11418
5.26	Single	8YNA	Immepip	8YNA-H₄-Immepip-Gi1/β1/γ
5.26	Single	9BQJ	RO76	9BQJ-μ-RO76-Gi1/β1/γ2
5.26	Single	9C2F	Ca; Ca; Tryptophan; '6218; PO4	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
5.26	Single	9MQJ	Isoquinuclidine	9MQJ-μ-Isoquinuclidine
5.26	Consensus	m2_on	Orthosteric Ligand	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2
5.26	Consensus	m2_on_gp	Orthosteric Ligand	7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2
5.26	Consensus	rhodopsin_off	Orthosteric Ligand	1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
5.26	Consensus	rhodopsin_on_gp	Orthosteric Ligand	6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.26	Consensus	s1p1_off	Orthosteric Ligand	3V2W-S1P₁-PubChem 51892645
5.26	Consensus	sensory_offon	Orthosteric Ligand	sensory_off sensory_on
5.26	Consensus	sensory_offon_gp	Orthosteric Ligand	sensory_on_gp sensory_on
5.00	Single	1F88	11-cis-Retinal	1F88-Rhodopsin-11-cis-Retinal
5.00	Single	2YDO	Adenosine	2YDO-A_2A-Adenosine
5.00	Single	3RZE	Cidoxepin	3RZE-H₁-Cidoxepin
5.00	Single	3UZC	4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol	3UZC-A_2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
5.00	Single	4DKL	Beta-Funaltrexamine	4DKL-μ-β-Funaltrexamine
5.00	Single	4MQT	Iperoxo	4MQT-M₂-Iperoxo-LY2119620
5.00	Single	4N6H	Naltrindole	4N6H-δ-Naltrindole-Na
5.00	Single	5IU7	Q27456346	5IU7-A_2A-Q27456346-Na
5.00	Single	5JTB	ZM-241385	5JTB-A_2A-ZM-241385
5.00	Single	5K2B	ZM-241385	5K2B-A_2A-ZM-241385-Na
5.00	Single	5TE3	Octyl-Beta-D-Glucopyranoside	5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
5.00	Single	5UVI	ZM-241385	5UVI-A_2A-ZM-241385
5.00	Single	6AQF	ZM-241385	6AQF-A_2A-ZM-241385
5.00	Single	6FK8	PubChem 132473035	6FK8-Rhodopsin-PubChem 132473035
5.00	Single	6K41	Dexmedetomidine	6K41-α_2b-Dexmedetomidine-Go/β1/γ2
5.00	Single	6MH8	ZM-241385	6MH8-A_2A-ZM-241385
5.00	Single	6PEL	Citronellol	6PEL-Rhodopsin-Citronellol-Gt(CT)
5.00	Single	6TPK	Retosiban	6TPK-OT-Retosiban
5.00	Single	6TPN	HTL6641	6TPN-OX₂-HTL6641
5.00	Single	6WH4	Methiothepin	6WH4-5-HT_2A-Methiothepin
5.00	Single	6WJC	Atropine	6WJC-M₁-Atropine-Muscarinic toxin 7
5.00	Single	6ZDR	HMS1413f12	6ZDR-A_2A-HMS1413f12-Na
5.00	Single	6ZG9	GSK1034702	6ZG9-M₁-GSK1034702
5.00	Single	7CMV	PD128907	7CMV-D₃-PD128907-Gi1/β1/γ2
5.00	Single	7E33	BRL-54443	7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2
5.00	Single	7EJ8	Brimonidine	7EJ8-α_2a-Brimonidine-Go/β1/γ2
5.00	Single	7EJA	Dexmedetomidine	7EJA-α_2a-Dexmedetomidine-Go/β1/γ2
5.00	Single	7T32	ZM-241385	7T32-A_2A-ZM-241385
5.00	Single	7T94	Acetylcholine	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
5.00	Single	7TRS	Acetylcholine	7TRS-M₄-Acetylcholine-Gi1/β1/γ2
5.00	Single	7WC9	PubChem 162421364	7WC9-5-HT_2A-PubChem 162421364
5.00	Single	7WVU	fMLF	7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
5.00	Single	8FCZ	11-cis-Retinal	8FCZ-Rhodopsin-11-cis-Retinal
5.00	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00	Single	8HNM	VUF11222	8HNM-CXCR3-VUF11222-Gi1/β1/γ2
5.00	Single	8JLK	Ulotaront	8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
5.00	Single	8JLN	T1AM	8JLN-TA1-T1AM-Gs/β1/γ2
5.00	Single	8JSP	Ulotaront	8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2
5.00	Single	8PM2	DMCH	8PM2-TA7-DMCH-Gs/β1/γ2
5.00	Single	8RQQ	ZM-241385	8RQQ-A_2A-ZM-241385-Na
5.00	Single	8THK	A61603	8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00	Single	8THL	Epinephrine	8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00	Single	8U02	L-Dopamine	8U02-D₂-L-Dopamine-Go/β1/γ2
5.00	Single	8UHB	RO5256390	8UHB-TA1-RO5256390-Gs/β1/γ2
5.00	Single	8VVG	GB18	8VVG-κ-GB18-Gi1/β1/γ2
5.00	Single	8W88	SEP-363856	8W88-TA1-SEP-363856-Gs/β1/γ2
5.00	Single	8W8B	SEP-363856	8W8B-5-HT_1A-SEP-363856-Gi1/β1/γ2
5.00	Single	8WC8	ZH8651	8WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
5.00	Single	8Y01	Retinal	8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
5.00	Single	8Y53	MK5046	8Y53-BB₃-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00	Single	8YN3	Histamine	8YN3-H₂-Histamine-Gs/β1/γ2
5.00	Single	8ZMG	Pimavanserin	8ZMG-5-HT_2A-Pimavanserin
5.00	Single	9ASB	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00	Single	9BJK	Naloxone	9BJK-μ-Naloxone-NAM
5.00	Single	9EPP	11,20-Ethanoretinal	9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
5.00	Single	9MQI	Isoquinuclidine	9MQI-μ-Isoquinuclidine
5.00	Consensus	a2_off	Orthosteric Ligand	a2a_off
5.00	Consensus	a2a_off	Orthosteric Ligand	3RFM-A_2A-Caffeine 8C9W-A_2A-Etrumadenant 3UZA-A_2A-GTPL9236 8GNG-A_2A-Istradefylline 8CU6-A_2A-LJ-4517 7PX4-A_2A-PSB-2113 7PYR-A_2A-PSB-2115 8DU3-A_2A-PubChem 105526064 8JWY-A_2A-2-118 8PWN-A_2A-Theophylline 5IU4-A_2A-ZM-241385-Na 5OLZ-A_2A-PubChem 135566609-Na 6GT3-A_2A-Imaradenant-Na 5OLV-A_2A-LUAA41063-Na 5N2R-A_2A-PSB-36-Na 5IU7-A_2A-Q27456346-Na 5OLH-A_2A-Vipadenant-Na 5OLO-A_2A-Tozadenant-Na 6ZDR-A_2A-HMS1413f12-Na 8GNE-A_2A-KW-6356-Na 8JWZ-A_2A-AB928-Na 5IU8-A_2A-Q27456347-Na 5IUB-A_2A-Q27456344-Na 6ZDV-A_2A-Chromone 5d-Na 5IUA-A_2A-Q27456348-Na 8A2P-A_2A-LUAA47070-Na
5.00	Consensus	alpha1_on	Orthosteric Ligand	alpha1a_on
5.00	Consensus	alpha1_on_gp	Orthosteric Ligand	alpha1a_on_gp
5.00	Consensus	alpha1a_on	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α_2a-Brimonidine-Go/β1/γ2 7EJA-α_2a-Dexmedetomidine-Go/β1/γ2 7EJK-α_2a-Oxymetazoline-Go/β1/γ2 7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α_2a-PubChem 164946676-Go/β1/γ2
5.00	Consensus	alpha1a_on_gp	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α_2a-Brimonidine-Go/β1/γ2 7EJA-α_2a-Dexmedetomidine-Go/β1/γ2 7EJK-α_2a-Oxymetazoline-Go/β1/γ2 7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α_2a-PubChem 164946676-Go/β1/γ2
5.00	Consensus	ghrelin_off	Orthosteric Ligand	6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
5.00	Consensus	opsins_off	Orthosteric Ligand	rhodopsin_off
5.00	Consensus	ot_off	Orthosteric Ligand	6TPK-OT-Retosiban
5.00	Consensus	sensory_off	Orthosteric Ligand	opsins_off
5.00	Consensus	vasop-oxy_off	Orthosteric Ligand	ot_off
4.88	Single	8F0J	Pramlintide Analogue San45	8F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
4.76	Single	3EML	ZM-241385	3EML-A_2A-ZM-241385
4.76	Single	3NY8	ICI118-551	3NY8-β₂-ICI118-551
4.76	Single	3NYA	S-Alprenolol	3NYA-β₂-S-Alprenolol
4.76	Single	3ZPQ	4-(piperazin-1- yl)-1H-indole	3ZPQ-β₁-4-(piperazin-1- yl)-1H-indole-Na
4.76	Single	3ZPR	4-methyl-2-(piperazin-1-yl)	3ZPR-β₁-4-methyl-2-(piperazin-1-yl)-Na
4.76	Single	4DAJ	Tiotropium	4DAJ-M₃-Tiotropium
4.76	Single	4EIY	ZM-241385	4EIY-A_2A-ZM-241385-Na
4.76	Single	4EJ4	Naltrindole	4EJ4-δ-Naltrindole
4.76	Single	4GBR	S-Carazolol	4GBR-β₂-S-Carazolol
4.76	Single	4MQS	Iperoxo	4MQS-M₂-Iperoxo
4.76	Single	4U14	Tiotropium	4U14-M₃-Tiotropium
4.76	Single	4U16	N-Methyl-Scopolamine	4U16-M₃-N-Methyl-Scopolamine
4.76	Single	4X1H	Nonyl-Beta-D-Glucopyranoside	4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
4.76	Single	5DSG	Tiotropium	5DSG-M₄-Tiotropium
4.76	Single	5IU8	Q27456347	5IU8-A_2A-Q27456347-Na
4.76	Single	5K2A	ZM-241385	5K2A-A_2A-ZM-241385-Na
4.76	Single	5OLG	ZM-241385	5OLG-A_2A-ZM-241385-Na
4.76	Single	5OLZ	PubChem 135566609	5OLZ-A_2A-PubChem 135566609-Na
4.76	Single	5OM1	PubChem 135566609	5OM1-A_2A-PubChem 135566609-Na
4.76	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
4.76	Single	5VRA	ZM-241385	5VRA-A_2A-ZM-241385-Na
4.76	Single	5YC8	N-Methyl-Scopolamine	5YC8-M₂-N-Methyl-Scopolamine
4.76	Single	5ZK8	N-Methyl-Scopolamine	5ZK8-M₂-N-Methyl-Scopolamine
4.76	Single	5ZKC	N-Methyl-Scopolamine	5ZKC-M₂-N-Methyl-Scopolamine
4.76	Single	6FK7	PubChem 132473034	6FK7-Rhodopsin-PubChem 132473034
4.76	Single	6FKC	PubChem 132473039	6FKC-Rhodopsin-PubChem 132473039
4.76	Single	6IIV	Daltroban	6IIV-TP-Daltroban
4.76	Single	6K42	Dexmedetomidine	6K42-α_2b-Dexmedetomidine-Gi1/β1/γ2
4.76	Single	6PS2	S-Alprenolol	6PS2-β₂-S-Alprenolol
4.76	Single	6S0L	ZM-241385	6S0L-A_2A-ZM-241385
4.76	Single	6WHA	DB13948	6WHA-5-HT_2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76	Single	7DB6	Ramelteon	7DB6-MT₁-Ramelteon-Gi1/β1/γ2
4.76	Single	7E32	Serotonin	7E32-5-HT_1D-Serotonin-Gi1/β1/γ2
4.76	Single	7PYR	PSB-2115	7PYR-A_2A-PSB-2115
4.76	Single	7TRP	Iperoxo	7TRP-M₄-Iperoxo-LY2033298-Gi1/β1/γ2
4.76	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/β1/γ2
4.76	Single	7VIF	S-FTY720-P	7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2
4.76	Single	7VKT	LTB4	7VKT-BLT₁-LTB4-Gi1/β1/γ2
4.76	Single	7WC7	Lisuride	7WC7-5-HT_2A-Lisuride
4.76	Single	7XTC	5-CT	7XTC-5-HT₇-5-CT-Gs/β1/γ2
4.76	Single	8CIC	Etrumadenant	8CIC-A_2A-Etrumadenant-Na
4.76	Single	8CU6	LJ-4517	8CU6-A_2A-LJ-4517
4.76	Single	8CU7	LJ-4517	8CU7-A_2A-LJ-4517-Na
4.76	Single	8DZS	GR89,696	8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
4.76	Single	8F2B	Pramlintide Analogue San45	8F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
4.76	Single	8FY8	5-MeO-DMT	8FY8-5-HT_1A-5-MeO-DMT-Gi1/β1/γ1
4.76	Single	8JD0	NAM563	8JD0-mGlu2; mGlu3-Glutamate-NAM563
4.76	Single	8JJO	Alprenolol	8JJO-β₂-Alprenolol
4.76	Single	8JLJ	T1AM	8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
4.76	Single	8JXR	LSD	8JXR-D₁-LSD
4.76	Single	8RLN	LUF5834	8RLN-A_2A-LUF5834
4.76	Single	8T1W	CVN424	8T1W-GPR6-CVN424
4.76	Single	8UH3	Setiptiline	8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1
4.76	Single	8W87	METH	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
4.76	Single	8W8A	RO5256390	8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
4.76	Single	8X9T	AP503	8X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
4.76	Single	8XVK	Ambrisentan	8XVK-ET_A-Ambrisentan
4.76	Single	8ZSS	RO5263397	8ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
4.76	Single	9AVG	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.76	Single	9CBM	Dexmedetomidine	9CBM-α_2a-Dexmedetomidine-Gi1/β1/γ2
4.76	Single	9CHX	S-Carazolol	9CHX-β₂-S-Carazolol
4.76	Consensus	5ht1d_on	Orthosteric Ligand	7E32-5-HT_1D-Serotonin-Gi1/β1/γ2
4.76	Consensus	5ht1d_on_gp	Orthosteric Ligand	7E32-5-HT_1D-Serotonin-Gi1/β1/γ2
4.76	Consensus	5ht7_on	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/β1/γ2
4.76	Consensus	5ht7_on_gp	Orthosteric Ligand	7XTC-5-HT₇-5-CT-Gs/β1/γ2
4.76	Consensus	alpha2_on	Orthosteric Ligand	alpha2b_on
4.76	Consensus	alpha2_on_gp	Orthosteric Ligand	alpha2b_on_gp
4.76	Consensus	alpha2b_on	Orthosteric Ligand	6K42-α_2b-Dexmedetomidine-Gi1/β1/γ2
4.76	Consensus	alpha2b_on_gp	Orthosteric Ligand	6K42-α_2b-Dexmedetomidine-Gi1/β1/γ2
4.76	Consensus	alpha_on	Orthosteric Ligand	alpha1_on alpha2_on
4.76	Consensus	blt1_on	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/β1/γ2
4.76	Consensus	blt1_on_gp	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/β1/γ2
4.76	Consensus	blt_on	Orthosteric Ligand	blt1_on
4.76	Consensus	blt_on_gp	Orthosteric Ligand	blt1_on_gp
4.76	Consensus	dop_off	Orthosteric Ligand	4EJ4-δ-Naltrindole
4.76	Consensus	dopamine_off	Orthosteric Ligand	d2_off d3_off
4.76	Consensus	gi_histamine	Orthosteric Ligand	8JXX-H₄-Clobenpropit-Gi1/β1/γ2 8JXV-H₄-Clozapine-Gi1/β1/γ2 8YUU-H₃-Histamine-Gi1/β1/γ1 8HN8-H₄-Histamine-Gi1/β1/γ2 8HOC-H₄-Imetit-Gi1/β1/γ2 8JXW-H₄-VUF6884-Gi1/β1/γ2
4.76	Consensus	gi_leukotriene	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/β1/γ2
4.76	Consensus	gq_amine	Orthosteric Ligand	gq_muscarinic gq_histamine
4.76	Consensus	gs_trace-amine	Orthosteric Ligand	8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
4.76	Consensus	leukotriene_on	Orthosteric Ligand	blt_on
4.76	Consensus	leukotriene_on_gp	Orthosteric Ligand	blt_on_gp
4.76	Consensus	m4_off	Orthosteric Ligand	5DSG-M₄-Tiotropium
4.76	Consensus	muscarinic_on	Orthosteric Ligand	m2_on m3_on m4_on m1_on
4.76	Consensus	muscarinic_on_gp	Orthosteric Ligand	m2_on_gp m3_on_gp m4_on_gp m1_on_gp
4.55	Single	2RH1	S-Carazolol	2RH1-β₂-S-Carazolol
4.55	Single	2YCW	S-Carazolol	2YCW-β₁-S-Carazolol
4.55	Single	4WW3	All-trans-Retinal	4WW3-Rhodopsin-All-trans-Retinal
4.55	Single	5CGC	HTL14242	5CGC-mGlu₅-HTL14242
4.55	Single	5D6L	S-Carazolol	5D6L-β₂-S-Carazolol
4.55	Single	5IUA	Q27456348	5IUA-A_2A-Q27456348-Na
4.55	Single	5N2R	PSB-36	5N2R-A_2A-PSB-36-Na
4.55	Single	5N2S	PSB36	5N2S-A₁-PSB36
4.55	Single	5NM2	ZM-241385	5NM2-A_2A-ZM-241385-Na
4.55	Single	5OM4	PubChem 135566609	5OM4-A_2A-PubChem 135566609-Na
4.55	Single	5X7D	S-Carazolol	5X7D-β₂-S-Carazolol-PubChem 129318963
4.55	Single	5XPR	Bosentan	5XPR-ET_B-Bosentan
4.55	Single	5ZK3	3-quinuclidinyl-benzilate	5ZK3-M₂-3-quinuclidinyl-benzilate
4.55	Single	6GDG	NECA	6GDG-A_2A-NECA-Gs/β1/γ1
4.55	Single	6HLP	Netupitant	6HLP-NK₁-Netupitant
4.55	Single	6LFL	PubChem 153466996	6LFL-CXCR2-PubChem 153466996
4.55	Single	6LPL	ZM-241385	6LPL-A_2A-ZM-241385-Na
4.55	Single	6OIK	Iperoxo	6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
4.55	Single	6PS6	Timolol	6PS6-β₂-Timolol
4.55	Single	6S0Q	ZM-241385	6S0Q-A_2A-ZM-241385
4.55	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
4.55	Single	6WQA	ZM-241385	6WQA-A_2A-ZM-241385-Na
4.55	Single	7C4S	S1P	7C4S-S1P₃-S1P
4.55	Single	7EPF	NAM597	7EPF-mGlu2; mGlu2-NAM597
4.55	Single	7EUO	fMLF	7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
4.55	Single	7RM5	ZM-241385	7RM5-A_2A-ZM-241385-Na
4.55	Single	7VUH	JNJ-63533054	7VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
4.55	Single	7W41	PD176252	7W41-BB₂-PD176252
4.55	Single	8C9W	Etrumadenant	8C9W-A_2A-Etrumadenant
4.55	Single	8EFB	Oliceridine	8EFB-μ-Oliceridine-Gi1/β1/γ2
4.55	Single	8FYN	ZM-241385	8FYN-A_2A-ZM-241385-Na
4.55	Single	8GDC	PGE2	8GDC-EP₃-PGE2-Gi1/β1/γ2
4.55	Single	8GNE	KW-6356	8GNE-A_2A-KW-6356-Na
4.55	Single	8QOT	Nanobody-E	8QOT-μ-Nanobody-E
4.55	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
4.55	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
4.55	Single	8YH0	NECA	8YH0-A_3A-NECA-Gi1/β1/γ2
4.55	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.55	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55	Single	9F34	FOB02-04A	9F34-D₃-FOB02-04A-Go1/β1/γ2
4.55	Single	9MQK	Isoquinuclidine	9MQK-κ-Isoquinuclidine
4.55	Consensus	5ht1_on	Orthosteric Ligand	5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
4.55	Consensus	5ht1_on_gp	Orthosteric Ligand	5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
4.55	Consensus	5ht1e_on_gp	Orthosteric Ligand	7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1
4.55	Consensus	5ht2_off	Orthosteric Ligand	5ht2a_off 5ht2b_off 5ht2c_off
4.55	Consensus	a1_off	Orthosteric Ligand	5UEN-A₁-DU172 5N2S-A₁-PSB36
4.55	Consensus	adenosine_off	Orthosteric Ligand	a1_off a2_off
4.55	Consensus	alpha_on_gp	Orthosteric Ligand	alpha1_on_gp alpha2_on_gp
4.55	Consensus	amine_off	Orthosteric Ligand	5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
4.55	Consensus	amine_offon	Orthosteric Ligand	amine_off amine_on
4.55	Consensus	amine_offon_gp	Orthosteric Ligand	amine_on_gp amine_off
4.55	Consensus	amine_on	Orthosteric Ligand	5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
4.55	Consensus	bb2_off	Orthosteric Ligand	7W41-BB₂-PD176252
4.55	Consensus	beta2_off	Orthosteric Ligand	2RH1-β₂-S-Carazolol 6PS3-β₂-S-Carvedilol 6PS5-β₂-S-Propranolol 3D4S-β₂-Timolol 3NY8-β₂-ICI118-551 3NY9-β₂-ICI118-551 6PRZ-β₂-S-Alprenolol
4.55	Consensus	beta_off	Orthosteric Ligand	beta1_off beta2_off
4.55	Consensus	blt1_off	Orthosteric Ligand	5X33-BLT₁-BIIL260 7K15-BLT₁-MKD046-Na
4.55	Consensus	blt_off	Orthosteric Ligand	blt1_off
4.55	Consensus	bombesin_off	Orthosteric Ligand	bb2_off
4.55	Consensus	gi_adrenergic	Orthosteric Ligand	7EJ0-α_2a-L-Norepinephrine-Go/β1/γ2 7EJK-α_2a-Oxymetazoline-Go/β1/γ2 7W7E-α_2a-PubChem 164946676-Go/β1/γ2 7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α_2a-Brimonidine-Go/β1/γ2 6K42-α_2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α_2a-Dexmedetomidine-Go/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
4.55	Consensus	m2_off	Orthosteric Ligand	5ZKC-M₂-N-Methyl-Scopolamine 5ZK3-M₂-3-quinuclidinyl-benzilate 5ZKB-M₂-AF-DX 384
4.55	Consensus	m3_on	Orthosteric Ligand	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M₃-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55	Consensus	m3_on_gp	Orthosteric Ligand	8E9Z-M₃-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M₃-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55	Consensus	s1p_off	Orthosteric Ligand	s1p1_off s1p5_off
4.55	Consensus	ta1_on	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.55	Consensus	trace-amine_on	Orthosteric Ligand	ta1_on
4.35	Single	2YDV	NECA	2YDV-A_2A-NECA
4.35	Single	3UON	3-quinuclidinyl-benzilate	3UON-M₂-3-quinuclidinyl-benzilate
4.35	Single	4DJH	JDTic	4DJH-κ-JDTic
4.35	Single	4OO9	Mavoglurant	4OO9-mGlu₅-Mavoglurant
4.35	Single	4U15	Tiotropium	4U15-M₃-Tiotropium
4.35	Single	4UHR	CGS21680	4UHR-A_2A-CGS21680
4.35	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
4.35	Single	5A8E	7-Methylcyanopindolol	5A8E-β₁-7-Methylcyanopindolol-Na
4.35	Single	5D5A	S-Carazolol	5D5A-β₂-S-Carazolol
4.35	Single	5D5B	S-Carazolol	5D5B-β₂-S-Carazolol
4.35	Single	5G53	NECA	5G53-A_2A-NECA-Gs
4.35	Single	5ZHP	PubChem 134828589	5ZHP-M₃-PubChem 134828589
4.35	Single	5ZKB	AF-DX 384	5ZKB-M₂-AF-DX 384
4.35	Single	6E59	L-760735	6E59-NK₁-L-760735
4.35	Single	6GT3	Imaradenant	6GT3-A_2A-Imaradenant-Na
4.35	Single	6J20	Aprepitant	6J20-NK₁-Aprepitant
4.35	Single	6J21	Aprepitant	6J21-NK₁-Aprepitant
4.35	Single	6OL9	Tiotropium	6OL9-M₅-Tiotropium
4.35	Single	6TQ7	SB-334867	6TQ7-OX₁-SB-334867
4.35	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
4.35	Single	7FEE	CP55940	7FEE-CB₁-CP55940-ZCZ011
4.35	Single	7PX4	PSB-2113	7PX4-A_2A-PSB-2113
4.35	Single	7T2H	Lofentanil	7T2H-μ-Lofentanil-Gi1/β1/γ2
4.35	Single	7U2L	PubChem 163201242	7U2L-μ-PubChem 163201242-Gi1/β1/γ2
4.35	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/β1/γ2
4.35	Single	7W6P	N-pyridin-4-ylisoquinolin-4-amine	7W6P-α_2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
4.35	Single	7W7E	PubChem 164946676	7W7E-α_2a-PubChem 164946676-Go/β1/γ2
4.35	Single	7WVX	Humanin	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
4.35	Single	7XY7	NECA	7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2
4.35	Single	8DZP	momSalB	8DZP-κ-momSalB-Gi1/β1/γ2
4.35	Single	8EF5	Fentanyl	8EF5-μ-Fentanyl-Gi1/β1/γ2
4.35	Single	8HDO	BAY 60-6583	8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
4.35	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
4.35	Single	8IRR	Rotigotine	8IRR-D₁-Rotigotine-Gs/β1/γ2
4.35	Single	8JPB	PubChem 118610427; GDP; Mg	8JPB-NTS₁-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
4.35	Single	8JXX	Clobenpropit	8JXX-H₄-Clobenpropit-Gi1/β1/γ2
4.35	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
4.35	Single	8T1V	PubChem 118310209	8T1V-GPR6-PubChem 118310209-Na
4.35	Single	8UGW	PubChem 3086599	8UGW-A_2A-PubChem 3086599
4.35	Single	8X16	Piclidenoson	8X16-A_3A-Piclidenoson-Gi1/β1/γ2
4.35	Single	8XJM	Latanoprost	8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
4.35	Single	8XVL	Zibotentan	8XVL-ET_A-Zibotentan
4.35	Single	8XZI	CMF-019	8XZI-Apelin-CMF-019-Gi1/β1/γ2
4.35	Single	8YH6	Namodenoson	8YH6-A_3A-Namodenoson-Gi1/β1/γ2
4.35	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.35	Consensus	a2_on	Orthosteric Ligand	a2b_on
4.35	Consensus	a2_on_gp	Orthosteric Ligand	a2b_on_gp
4.35	Consensus	a2b_on	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
4.35	Consensus	a2b_on_gp	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
4.35	Consensus	amine_on_gp	Orthosteric Ligand	5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
4.35	Consensus	beta1_off	Orthosteric Ligand	2VT4-β₁-Cyanopindolol 2YCW-β₁-S-Carazolol 2YCZ-β₁-Iodocyanopindolol 5A8E-β₁-7-Methylcyanopindolol-Na 3ZPQ-β₁-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β₁-4-methyl-2-(piperazin-1-yl)-Na
4.35	Consensus	class-a_off	Orthosteric Ligand	sensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
4.35	Consensus	gs_adenosine	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
4.35	Consensus	gs_nucleotide	Orthosteric Ligand	gs_adenosine
4.35	Consensus	h4_on_gp	Orthosteric Ligand	8HN8-H₄-Histamine-Gi1/β1/γ2 8HOC-H₄-Imetit-Gi1/β1/γ2 8JXV-H₄-Clozapine-Gi1/β1/γ2 8JXW-H₄-VUF6884-Gi1/β1/γ2 8JXX-H₄-Clobenpropit-Gi1/β1/γ2
4.35	Consensus	kop_off	Orthosteric Ligand	4DJH-κ-JDTic
4.35	Consensus	m3_off	Orthosteric Ligand	4U15-M₃-Tiotropium 4U16-M₃-N-Methyl-Scopolamine 5ZHP-M₃-PubChem 134828589
4.35	Consensus	m5_off	Orthosteric Ligand	6OL9-M₅-Tiotropium
4.35	Consensus	muscarinic_off	Orthosteric Ligand	m2_off m3_off m4_off m5_off m1_off
4.35	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
4.35	Consensus	s1p5_on_gp	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
4.35	Consensus	ta1_on_gp	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.35	Consensus	tachykinin_off	Orthosteric Ligand	nk1_off
4.35	Consensus	trace-amine_on_gp	Orthosteric Ligand	ta1_on_gp
4.17	Single	3D4S	Timolol	3D4S-β₂-Timolol
4.17	Single	4AMI	Bucindolol	4AMI-β₁-Bucindolol
4.17	Single	4N4W	SANT-1	4N4W-SMO-SANT-1
4.17	Single	4OR2	FITM	4OR2-mGlu1; mGlu1-FITM
4.17	Single	4Z36	ONO-3080573	4Z36-LPA₁-ONO-3080573
4.17	Single	5CXV	Tiotropium	5CXV-M₁-Tiotropium
4.17	Single	5F8U	Cyanopindolol	5F8U-β₁-Cyanopindolol
4.17	Single	5LWE	Vercirnon	5LWE-CCR9-Vercirnon
4.17	Single	5UNH	PubChem 126456406	5UNH-AT₂-PubChem 126456406
4.17	Single	5X33	BIIL260	5X33-BLT₁-BIIL260
4.17	Single	6AK3	Dinoprostone IPGE2	6AK3-EP₃-Dinoprostone IPGE2
4.17	Single	6H7N	S-Xamoterol	6H7N-β₁-S-Xamoterol
4.17	Single	6H7O	Cyanopindolol	6H7O-β₁-Cyanopindolol
4.17	Single	6IIU	Ramatroban	6IIU-TP-Ramatroban
4.17	Single	6KQI	CP55940	6KQI-CB₁-CP55940-Org27569
4.17	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
4.17	Single	6ZG4	HTL0009936	6ZG4-M₁-HTL0009936
4.17	Single	7EO4	BAF312	7EO4-S1P₁-BAF312-Gi1/β1/γ2
4.17	Single	7EPE	NAM563	7EPE-mGlu2; mGlu2-NAM563
4.17	Single	7EXD	Lasmiditan	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
4.17	Single	7JNI	Olodanrigan	7JNI-AT₂-Olodanrigan
4.17	Single	7K15	MKD046	7K15-BLT₁-MKD046-Na
4.17	Single	7T6B	S1P	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/β1/γ2
4.17	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
4.17	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
4.17	Single	7YIT	Nalfurafine	7YIT-κ-Nalfurafine
4.17	Single	8E9W	2-Deoxycytidine	8E9W-M₃-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17	Single	8FYE	4-F,5-MeO-PyrT	8FYE-5-HT_1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
4.17	Single	8FYT	LSD	8FYT-5-HT_1A-LSD-Gi1/β1/γ1
4.17	Single	8G05	6-OAU	8G05-GPR84-6-OAU-Gi1/β1/γ2
4.17	Single	8ID9	Eicosapentaenoic acid	8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
4.17	Single	8IQ6	Latanoprost	8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Single	8IRS	Rotigotine	8IRS-D₂-Rotigotine-Gi1/β1/γ2
4.17	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
4.17	Single	8JWY	2-118	8JWY-A_2A-2-118
4.17	Single	8JWZ	AB928	8JWZ-A_2A-AB928-Na
4.17	Single	8T3Q	Docosa-4,7,10,13,16,19-Hexaenoic acid	8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17	Single	8XJN	Cloprosetnol	8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17	Single	9MQL	Isoquinuclidine	9MQL-κ-Isoquinuclidine
4.17	Consensus	5ht1f_on	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
4.17	Consensus	5ht1f_on_gp	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
4.17	Consensus	cannabinoid_off	Orthosteric Ligand	cb2_off cb1_off
4.17	Consensus	gi_amine	Orthosteric Ligand	gi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
4.17	Consensus	gi_muscarinic	Orthosteric Ligand	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2
4.17	Consensus	leukotriene_off	Orthosteric Ligand	blt_off cyslt_off
4.17	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z35-LPA₁-ONO-9910539 4Z34-LPA₁-ONO-9780307
4.17	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
4.17	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
4.17	Consensus	m1_off	Orthosteric Ligand	5CXV-M₁-Tiotropium
4.17	Consensus	m4_on	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2
4.17	Consensus	m4_on_gp	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2
4.17	Consensus	mop_on	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
4.17	Consensus	mop_on_gp	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
4.17	Consensus	nk1_off	Orthosteric Ligand	6HLP-NK₁-Netupitant 6HLO-NK₁-Aprepitant 6HLL-NK₁-CP99994 6E59-NK₁-L-760735
4.17	Consensus	opioid_off	Orthosteric Ligand	mop_off nop_off dop_off kop_off
4.17	Consensus	s1p1_on	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
4.17	Consensus	s1p1_on_gp	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
4.00	Single	2YCZ	Iodocyanopindolol	2YCZ-β₁-Iodocyanopindolol
4.00	Single	4BVN	Cyanopindolol	4BVN-β₁-Cyanopindolol-Na
4.00	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
4.00	Single	5X93	K-8794	5X93-ET_B-K-8794
4.00	Single	6K1Q	IRL2500	6K1Q-ET_B-IRL2500
4.00	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/β1/γ2
4.00	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/β1/γ2
4.00	Single	7EZC	UKA	7EZC-A_2A-UKA
4.00	Single	7SK8	CCX662	7SK8-ACKR3-CXCL12-CCX662
4.00	Single	7U2K	C6-guano	7U2K-μ-C6-guano-Gi1/β1/γ2
4.00	Single	7VGY	2-Iodomelatonin	7VGY-MT₁-2-Iodomelatonin-Gi1/β1/γ2
4.00	Single	7WVV	fMLFII	7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
4.00	Single	7X2D	Tavapadon	7X2D-D₁-Tavapadon-Gs/β1/γ2
4.00	Single	7XJI	Solabegron	7XJI-β₃-Solabegron-Gs/β1/γ2
4.00	Single	8E9X	2-Deoxycytidine	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
4.00	Single	8E9Y	Clozapine-N-oxide	8E9Y-M₃-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.00	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/β1/γ2
4.00	Single	8GUT	LEI-102	8GUT-CB₂-LEI-102-Gi1/β1/γ2
4.00	Single	8ID8	TUG-891	8ID8-FFA4-TUG-891-Gi1/β1/γ2
4.00	Single	8IUL	Latanoprost	8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
4.00	Single	8J19	LY237	8J19-GPR84-LY237-Gi1/β1/γ2
4.00	Single	8JD3	HZR; PEF	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
4.00	Single	8T3O	TUG-891	8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.00	Single	8XIO	L797591	8XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.00	Single	8XJK	Cloprosetnol	8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00	Single	8XJO	U46619	8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00	Single	8XVJ	Macitentan	8XVJ-ET_A-Macitentan
4.00	Consensus	endothelin_off	Orthosteric Ligand	etb_off
4.00	Consensus	etb_off	Orthosteric Ligand	5X93-ET_B-K-8794 5XPR-ET_B-Bosentan 6K1Q-ET_B-IRL2500
4.00	Consensus	gi_s1p	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7EW3-S1P₃-S1P-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EW1-S1P₅-Siponimod-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
4.00	Consensus	kop_on_gp	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
4.00	Consensus	peptide_off	Orthosteric Ligand	cck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
4.00	Consensus	prostanoid_on	Orthosteric Ligand	tp_on fp-alpha_on
4.00	Consensus	prostanoid_on_gp	Orthosteric Ligand	tp_on_gp fp-alpha_on_gp
4.00	Consensus	tp_on	Orthosteric Ligand	8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00	Consensus	tp_on_gp	Orthosteric Ligand	8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85	Single	3NY9	ICI118-551	3NY9-β₂-ICI118-551
3.85	Single	4UG2	CGS21680	4UG2-A_2A-CGS21680
3.85	Single	5EE7	MK0893	5EE7-Glucagon-MK0893
3.85	Single	5WF6	UK-432097	5WF6-A_2A-UK-432097
3.85	Single	5ZTY	AM10257	5ZTY-CB₂-AM10257
3.85	Single	6G79	Donitriptan	6G79-5-HT_1B-Donitriptan-Go/β1/γ2
3.85	Single	6OMM	WKYMVX	6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
3.85	Single	6PT3	DPI-287	6PT3-δ-DPI-287
3.85	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
3.85	Single	7CX2	PGE2	7CX2-EP₂-PGE2-Gs/β1/γ2
3.85	Single	7SK9	CCX662	7SK9-ACKR3-CCX662
3.85	Single	7XY6	BAY 60-6583	7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
3.85	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
3.85	Single	8JLR	A77636	8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
3.85	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
3.85	Single	8XQO	Cholesterol	8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
3.85	Consensus	cb2_off	Orthosteric Ligand	5ZTY-CB₂-AM10257
3.85	Consensus	formylpeptide_on	Orthosteric Ligand	fpr2-alx_on fpr1-alx_on
3.70	Single	4AMJ	S-Carvedilol	4AMJ-β₁-S-Carvedilol
3.70	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
3.70	Single	7T6U	CGEN-855A	7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
3.70	Single	7WVW	fMYFINILTL	7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
3.70	Single	8FYL	Vilazodone	8FYL-5-HT_1A-Vilazodone-Gi1/β1/γ1
3.70	Single	8G59	TUG-891	8G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
3.70	Single	8PKM	Befiradol	8PKM-5-HT_1A-Befiradol-t7m-Gi1/β1/γ1
3.70	Single	8WDT	photoNECA	8WDT-A_2A-photoNECA
3.70	Single	8ZSP	LSD	8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.70	Consensus	gi_opioid	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
3.70	Consensus	mop_off	Orthosteric Ligand	4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
3.57	Single	3QAK	UK-432097	3QAK-A_2A-UK-432097
3.57	Single	6HLO	Aprepitant	6HLO-NK₁-Aprepitant
3.57	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
3.57	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/β1/γ2
3.57	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
3.57	Consensus	gq_class-a	Orthosteric Ligand	gq_peptide gq_amine gq_nucleotide
3.57	Consensus	s1p3_on_gp	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
3.45	Single	5WF5	UK-432097	5WF5-A_2A-UK-432097
3.45	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
3.45	Single	6PT2	KGCHM07	6PT2-δ-KGCHM07
3.45	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
3.45	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/β1/γ2
3.45	Single	9B54	A1AIW	9B54-CB₁-A1AIW-Gi1/β1/γ2
3.33	Single	6JOD	Angiotensin II	6JOD-AT₂-Angiotensin II
3.33	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
3.33	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/β1/γ2
3.33	Single	8IED	A1LYA	8IED-GPR156-A1LYA-Go/β1/γ2
3.23	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
3.23	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
3.23	Single	7XV3	Lysophosphatidylserine	7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
3.23	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/β1/γ2
3.23	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23	Single	8HCX	Endothelin-1	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.23	Single	8ZRT	ET-1	8ZRT-ET_B-ET-1
3.23	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23	Consensus	eta_on_gp	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
3.12	Single	6NBF	Long-Acting PTH Analog	6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
3.12	Single	6NBI	Long-Acting PTH Analog	6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
3.12	Single	6P9Y	PACAP	6P9Y-PAC₁-PACAP-Gs/β1/γ2
3.12	Single	7D3S	Secretin	7D3S-Secretin-Secretin-Gs/β1/γ2
3.12	Single	7W3Z	Gastrin Releasing Peptide	7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
3.12	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/β1/γ2
3.12	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
3.03	Single	6P9X	Corticoliberin	6P9X-CRF₁-Corticoliberin-Gs/β1/γ2
3.03	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
3.03	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
3.03	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
3.03	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/β1/γ2
2.94	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/β1/γ2
2.94	Single	6IGL	IRL1620	6IGL-ET_B-IRL1620
2.94	Single	6NBH	Long-Acting PTH Analog	6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
2.94	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/β1/γ2
2.94	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
2.94	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/β1/γ2
2.94	Single	8F0K	Pramlintide Analogue San385	8F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
2.94	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
2.94	Single	8Y52	BA1	8Y52-BB₃-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
2.94	Consensus	endothelin_on	Orthosteric Ligand	etb_on eta_on
2.94	Consensus	etb_on	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
2.86	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
2.86	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
2.86	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
2.86	Consensus	bb2_on	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
2.86	Consensus	bb2_on_gp	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
2.86	Consensus	bombesin_on	Orthosteric Ligand	bb2_on
2.86	Consensus	bombesin_on_gp	Orthosteric Ligand	bb2_on_gp
2.86	Consensus	gi_endothelin	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
2.86	Consensus	gq_bombesin	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
2.78	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/β1/γ1
2.78	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/β1/γ2
2.78	Single	8FLU	Long-Acting PTH	8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
2.78	Single	8HBD	IRL1620	8HBD-ET_B-IRL1620-Gi1/β1/γ2
2.78	Consensus	endothelin_on_gp	Orthosteric Ligand	etb_on_gp eta_on_gp
2.78	Consensus	etb_on_gp	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
2.70	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
2.70	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
2.70	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/β1/γ2
2.63	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/β1/γ2
2.63	Single	9JR3	PTH	9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.44	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/β1/γ2

PDB Summary
PDB	4Z9G
Class	B1
SubFamily	Peptide
Type	Corticotropin Releasing Factor
SubType	CRF1
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	CP-376395
Protein Partners	-
PDB Resolution	3.18
Date	2016-06-29
D.O.I.	10.2174/1874467210666170110114727

Net Summary
I_min	3.71
Number of Linked Nodes	245
Number of Links	262
Number of Hubs	30
Number of Links mediated by Hubs	122
Number of Communities	7
Number of Nodes involved in Communities	40
Number of Links involved in Communities	49

Path Summary
Number Of Nodes in MetaPath	71
Number Of Links MetaPath	70
Number of Shortest Paths	29595
Length Of Smallest Path	3
Average Path Length	15.0678
Length of Longest Path	39
Minimum Path Strength	1.405
Average Path Strength	7.15897
Maximum Path Strength	26.14
Minimum Path Correlation	0.7
Average Path Correlation	0.920531
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	44.2766
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	37.4035
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• hydrolase activity, acting on glycosyl bonds • peptidoglycan muralytic activity • hydrolase activity, hydrolyzing O-glycosyl compounds • lysozyme activity • hydrolase activity • catalytic activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • corticotrophin-releasing factor receptor activity • amide binding • binding • peptide hormone binding • hormone binding • corticotropin-releasing hormone binding • peptide receptor activity • G protein-coupled peptide receptor activity • corticotropin-releasing hormone receptor activity • biological process involved in interspecies interaction between organisms • response to stimulus • response to other organism • defense response • response to external stimulus • response to biotic stimulus • defense response to bacterium • defense response to other organism • response to stress • response to bacterium • response to external biotic stimulus • carbohydrate derivative catabolic process • catabolic process • peptidoglycan catabolic process
Gene Ontology	Biological Process	• biological process involved in interspecies interaction between organisms • response to stimulus • response to other organism • defense response • response to external stimulus • response to biotic stimulus • defense response to bacterium • defense response to other organism • response to stress • response to bacterium • response to external biotic stimulus • carbohydrate derivative catabolic process • catabolic process • peptidoglycan catabolic process • glycosaminoglycan metabolic process • carbohydrate derivative metabolic process • aminoglycan catabolic process • macromolecule catabolic process • glycosaminoglycan catabolic process • aminoglycan metabolic process • peptidoglycan metabolic process • metabolic process • cellular process • macromolecule metabolic process • symbiont-mediated cytolysis of host cell • viral life cycle • disruption of cell in another organism • cytolysis • biological process involved in interaction with host • biological process involved in symbiotic interaction • viral release from host cell by cytolysis • exit from host cell • viral process • cytolysis in another organism • viral release from host cell • disruption of anatomical structure in another organism • symbiont-mediated killing of host cell • killing of cells of another organism • cell killing • cell wall organization or biogenesis • cell wall macromolecule catabolic process • cell wall macromolecule metabolic process • cellular response to stimulus • cellular response to nitrogen compound • response to corticotropin-releasing hormone • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular response to corticotropin-releasing hormone stimulus • cellular response to hormone stimulus • multicellular organismal process • system process • nitrogen compound transport • transport • signaling • hormone secretion • cell communication • peptide secretion • localization • secretion by cell • amide transport • signal release • regulation of biological quality • regulation of biological process • secretion • corticotropin secretion • regulation of hormone levels • biological regulation • cell-cell signaling • export from cell • establishment of localization • peptide transport • endocrine hormone secretion • endocrine process • peptide hormone secretion • hormone transport • behavior • exploration behavior • multi-multicellular organism process • reproductive process • female pregnancy • multi-organism reproductive process • immune response • immune system process • regulation of localization • corticosterone secretion • regulation of cellular process • regulation of system process • regulation of glucocorticoid secretion • regulation of steroid hormone secretion • lipid transport • regulation of corticosteroid hormone secretion • regulation of secretion • lipid export from cell • glucocorticoid secretion • regulation of endocrine process • corticosteroid hormone secretion • regulation of corticosterone secretion • regulation of hormone secretion • steroid hormone secretion • regulation of lipid transport • organic hydroxy compound transport • regulation of secretion by cell • regulation of multicellular organismal process • regulation of signaling • regulation of transport • lipid localization • regulation of lipid localization • macromolecule localization • regulation of cell communication • general adaptation syndrome • general adaptation syndrome, behavioral process • multicellular organismal response to stress • parturition • fear response • adult behavior • response to alcohol • behavioral response to ethanol • response to ethanol • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • cell surface receptor signaling pathway • developmental process • multicellular organism development • adrenal gland development • endocrine system development • gland development • animal organ development • anatomical structure development • system development • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • regulation of calcium ion transmembrane transporter activity • regulation of calcium ion transport • negative regulation of voltage-gated calcium channel activity • negative regulation of ion transmembrane transporter activity • negative regulation of calcium ion transmembrane transporter activity • negative regulation of biological process • negative regulation of transport • regulation of voltage-gated calcium channel activity • calcium ion transport • negative regulation of cation transmembrane transport • monoatomic cation transport • regulation of monoatomic ion transport • inorganic ion transmembrane transport • regulation of cation channel activity • inorganic cation transmembrane transport • transmembrane transport • regulation of transmembrane transport • negative regulation of calcium ion transmembrane transport • negative regulation of cation channel activity • monoatomic ion transmembrane transport • negative regulation of monoatomic ion transport • regulation of transmembrane transporter activity • regulation of monoatomic ion transmembrane transport • metal ion transport • negative regulation of transmembrane transport • regulation of transporter activity • regulation of calcium ion transmembrane transport • monoatomic cation transmembrane transport • negative regulation of monoatomic ion transmembrane transport • negative regulation of cellular process • monoatomic ion transport • regulation of metal ion transport • regulation of monoatomic ion transmembrane transporter activity • negative regulation of transporter activity • negative regulation of molecular function • negative regulation of calcium ion transport • regulation of monoatomic cation transmembrane transport • calcium ion transmembrane transport • host cellular component • host intracellular part • cellular anatomical structure • host cell cytoplasm • host cell part • host intracellular region • postsynaptic specialization membrane • postsynaptic specialization • synapse • membrane • plasma membrane • postsynaptic density membrane • synaptic membrane • cell periphery
Gene Ontology	Cellular Component	• host cellular component • host intracellular part • cellular anatomical structure • host cell cytoplasm • host cell part • host intracellular region • postsynaptic specialization membrane • postsynaptic specialization • synapse • membrane • plasma membrane • postsynaptic density membrane • synaptic membrane • cell periphery • postsynaptic density • postsynapse • neuron to neuron synapse • organelle • cell junction • postsynaptic membrane • asymmetric synapse • plasma membrane region • glutamatergic synapse • cell projection • neuron projection • plasma membrane bounded cell projection • membrane-bounded organelle • intracellular anatomical structure • endosome • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • cytoplasm • vesicle
SCOP2	Domain Identifier	• G protein-coupled receptor-like
SCOP2	Family Identifier	• G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	1Q5
PDB Residues	W:W:?4
Environment Details	Open EMBL-EBI Page
Code	1Q5
Name	3,6-dimethyl-N-(pentan-3-yl)-2-(2,4,6-trimethylphenoxy)pyridin-4-amine
Synonyms
Identifier
Formula	C21 H30 N2 O
Molecular Weight	326.476
SMILES
PubChem	9862166
Formal Charge	0
Total Atoms	54
Total Chiral Atoms	0
Total Bonds	55
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P34998-2
Sequence	>4Z9G_Chain_R K S K V H Y H V A A I I N Y L G H C I S L V A L L V A F V L F L R A R S I R C L R N I I H A N L I A A F I L R N A T W F V V Q L T M S P E V H Q S N V G W C R L V T A A Y N Y F H V T N F F W M F G E G C Y L H T A I V L T L T D R L R A W M F I C I G W G V P F P I I V A W A I G K L Y Y D N E K C W A G K R P G V Y T D Y I Y Q G P M A L V L L I N F I F L F N I V R I L M T K L R A S T T S E T I Q A R K A V K A T L V L L P L L G I T Y M L A F V N P G E D E V S R V V F I Y F N A F L E S F Q G F F V S V F A C F L N S E V R S Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8GTM	B1	Peptide	Corticotropin Releasing Factor	CRF₁	Homo sapiens	-	BMK-C203	-	2.6	2023-09-13	10.1038/s12276-023-01082-1
	8GTI	B1	Peptide	Corticotropin Releasing Factor	CRF₁	Homo sapiens	-	BMK-C205	-	2.2	2023-09-13	10.1038/s12276-023-01082-1
	8GTG	B1	Peptide	Corticotropin Releasing Factor	CRF₁	Homo sapiens	-	BMK-I152	-	2.75	2023-09-13	10.1038/s12276-023-01082-1
	6PB0	B1	Peptide	Corticotropin Releasing Factor	CRF₁	Homo sapiens	Urocortin	-	chim(NtGi1-Gs)/β1/γ2	3	2020-02-12	10.1016/j.molcel.2020.01.013
	6PB0 (No Gprot)	B1	Peptide	Corticotropin Releasing Factor	CRF₁	Homo sapiens	Urocortin	-		3	2020-02-12	10.1016/j.molcel.2020.01.013
	6P9X	B1	Peptide	Corticotropin Releasing Factor	CRF₁	Homo sapiens	Corticoliberin	-	Gs/β1/γ2	2.91	2020-02-05	10.1016/j.molcel.2020.01.012
	6P9X (No Gprot)	B1	Peptide	Corticotropin Releasing Factor	CRF₁	Homo sapiens	Corticoliberin	-		2.91	2020-02-05	10.1016/j.molcel.2020.01.012
	4K5Y	B1	Peptide	Corticotropin Releasing Factor	CRF₁	Homo sapiens	-	CP-376395	-	2.98	2013-07-17	10.1038/nature12357

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