Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:S16 4.5725437
2A:A:V34 4.714545
3A:A:L38 3.1425448
4A:A:K46 3.485449
5A:A:M53 5.51448
6A:A:F189 5.388509
7A:A:F191 7.8925445
8A:A:L194 5.6525444
9A:A:K197 6.215416
10A:A:F199 8.776515
11A:A:Q204 5.814519
12A:A:R208 5.162519
13A:A:K210 5.3775419
14A:A:W211 7.47519
15A:A:F215 8.204519
16A:A:I221 5.1875418
17A:A:I222 3.1025447
18A:A:V225 3.685417
19A:A:Y230 5.9518
20A:A:R242 4.52409
21A:A:F250 9.466519
22A:A:N255 9.425408
23A:A:W258 6.80833615
24A:A:I265 4.615448
25A:A:L266 4.36619
26A:A:F267 6.13167649
27A:A:L268 4.482518
28A:A:N269 6.6575449
29A:A:K270 3.7954129
30A:A:L273 4.4565126
31A:A:F274 5.48833619
32A:A:I278 5.18416
33A:A:L283 4.402517
34A:A:C286 4.012516
35A:A:Y287 4.27286717
36A:A:Y290 7.57407
37A:A:Y296 11.5025404
38A:A:I303 4.196517
39A:A:F307 3.884518
40A:A:N311 5.1175418
41A:A:R313 4514
42A:A:I319 4.8025415
43A:A:Y320 7.73167647
44A:A:H322 9.05449
45A:A:T324 6.874549
46A:A:N331 4.27448
47A:A:V332 4.5475447
48A:A:F336 4.576548
49A:A:L353 3.0125407
50G:G:Y40 8.59456
51G:G:D48 6.9145159
52G:G:P49 3.895407
53G:G:L51 3.5425406
54G:G:N59 6.83439
55G:G:P60 9.3439
56G:G:F61 6.0661038
57R:R:L30 5.0875426
58R:R:L54 7.584118
59R:R:N59 6.0854119
60R:R:Y60 4.9154166
61R:R:L65 4.44167629
62R:R:T68 3.675428
63R:R:D69 5.61167629
64R:R:V72 3.63407
65R:R:V76 3.925407
66R:R:M77 4.168528
67R:R:Y83 5.34754105
68R:R:V85 2.6375405
69R:R:W89 7.678336108
70R:R:M91 3.1225406
71R:R:I98 3.3954184
72R:R:W99 8.09754106
73R:R:V102 3.4954185
74R:R:D103 8.0625428
75R:R:C109 6.485427
76R:R:I111 4.3875428
77R:R:H113 8.366528
78R:R:L114 6.234529
79R:R:R121 6.865409
80R:R:Y122 8.1975408
81R:R:Y131 11.40754178
82R:R:R135 8.26754177
83R:R:S151 3.265408
84R:R:H176 7.116525
85R:R:F190 7.35571728
86R:R:Y191 4.3475406
87R:R:L200 4.6225406
88R:R:Y201 6.3675409
89R:R:K209 7.0054136
90R:R:E288 6.054138
91R:R:L295 3.7575408
92R:R:F302 6.352529
93R:R:W306 5.7425829
94R:R:F309 5.82167627
95R:R:F310 8.5325426
96R:R:K312 5.40833625
97R:R:E313 7.2575426
98R:R:V316 4.1525424
99R:R:N317 6.9525426
100R:R:V318 2.6975405
101R:R:E326 5.4654102
102R:R:W334 6.645627
103R:R:Y337 6.1075427
104R:R:N339 6.312529
105R:R:L341 5.7225426
106R:R:N343 7.58167629
107R:R:I346 4.21333628
108R:R:Y347 7.67529
109R:R:F354 9.546676118
110R:R:F358 3.83254118
111L:L:?1 8.797141420
112B:B:L14 3.79408
113B:B:D27 5.05408
114B:B:I37 3.822502
115B:B:H54 8.81833639
116B:B:K57 8.8025419
117B:B:Y59 9.445618
118B:B:M61 5.115436
119B:B:W63 7.60167637
120B:B:V71 4.2925468
121B:B:D76 7.945439
122B:B:K78 5.446538
123B:B:L79 4.772567
124B:B:I80 6.02167638
125B:B:I81 5.232567
126B:B:W82 9.99833639
127B:B:N88 7.0325437
128B:B:K89 5.55667639
129B:B:H91 6.245465
130B:B:I93 7.27467
131B:B:L95 5.11568
132B:B:W99 8.2719
133B:B:Y105 4.875666
134B:B:V112 5.3325468
135B:B:C114 4.6125468
136B:B:L117 3.7975419
137B:B:N119 5.6225419
138B:B:I123 5.01406
139B:B:Y124 5.945666
140B:B:L126 5.515465
141B:B:T128 2.5525403
142B:B:V133 6.455464
143B:B:L139 3.964509
144B:B:H142 7.54699
145B:B:Y145 6.16875818
146B:B:L146 3.608597
147B:B:R150 6.18754196
148B:B:F151 5.30833609
149B:B:L152 6.375403
150B:B:I157 5.4025407
151B:B:T159 4.77833699
152B:B:D163 8.75499
153B:B:W169 7.524598
154B:B:F180 9.71477
155B:B:H183 6.83571779
156B:B:D186 5.12667619
157B:B:V187 4.702579
158B:B:M188 7.65418
159B:B:L190 5.934575
160B:B:F199 8.3175479
161B:B:S201 4.338579
162B:B:C204 7.765417
163B:B:D205 6.244579
164B:B:S207 4.84475
165B:B:K209 7.312576
166B:B:L210 4.33405
167B:B:W211 8.87678
168B:B:D212 8.12754209
169B:B:Q220 8.705407
170B:B:F222 9.9375488
171B:B:H225 7.5689
172B:B:I232 7.305488
173B:B:F235 5.87857756
174B:B:P236 6.3775457
175B:B:F241 7.61667686
176B:B:T243 6.846588
177B:B:D247 7.5125409
178B:B:T249 5.085486
179B:B:R251 7.20667688
180B:B:F253 6.67833686
181B:B:D254 6.54409
182B:B:R256 10.2575409
183B:B:Y264 4.8075455
184B:B:F278 6.5275457
185B:B:R283 6.4525459
186B:B:L285 4.75556
187B:B:Y289 6.85333657
188B:B:N295 8.43456
189B:B:V296 3.63405
190B:B:W297 4.5075458
191B:B:L300 4.91456
192B:B:K301 4.632505
193B:B:R304 5.895655
194B:B:H311 9.63419
195B:B:N313 3.595417
196B:B:R314 14.3475418
197B:B:M325 4.96714735
198B:B:W332 10.9029719
199B:B:D333 5.572519
200B:B:K337 7.422516
201B:B:W339 8.404519
202B:B:N340 5.8025439
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:I80 B:B:K78 22.96562.91YesYes388
2B:B:M325 G:G:P49 47.12825.03YesYes057
3G:G:D48 G:G:P49 48.54673.22YesYes097
4G:G:D48 G:G:L51 49.49538.14YesYes096
5B:B:V40 G:G:L51 50.43272.98NoYes036
6B:B:I43 B:B:V40 71.24943.07NoNo033
7B:B:I43 B:B:M45 75.97952.92NoNo034
8B:B:M45 B:B:W339 76.19645.82NoYes149
9B:B:T329 B:B:W339 38.2838.49NoYes089
10B:B:H311 B:B:T329 38.39115.48YesNo098
11B:B:D333 B:B:H311 77.33277.56YesYes199
12B:B:D333 B:B:N313 77.97992.69YesYes197
13B:B:N313 B:B:W332 77.95435.65YesYes179
14B:B:W332 B:B:Y59 78.914812.54YesYes198
15A:A:C214 B:B:Y59 79.93134.03NoYes178
16A:A:C214 A:A:F215 74.76385.59NoYes179
17B:B:M325 G:G:F61 39.66243.73YesYes358
18B:B:K337 B:B:W339 38.33644.64YesYes169
19B:B:H311 B:B:K337 38.866415.72YesYes196
20A:A:F215 A:A:W211 75.8364.01YesYes199
21A:A:R208 A:A:W211 93.71377YesYes199
22A:A:L249 A:A:R208 94.29713.64NoYes199
23A:A:F223 A:A:L249 94.98078.53NoNo199
24A:A:F223 A:A:L266 94.24563.65NoYes199
25A:A:L266 A:A:L268 94.63732.77YesYes198
26A:A:F323 A:A:L268 93.76716.09NoYes048
27A:A:F323 A:A:K271 93.89273.72NoNo045
28A:A:C325 A:A:K271 99.9384.85NoNo075
29A:A:C325 A:A:N269 1006.3NoYes079
30A:A:N269 A:A:T324 34.80315.85YesYes499
31A:A:I49 A:A:N269 65.320711.33NoYes479
32A:A:I49 A:A:M53 65.3524.37NoYes478
33A:A:F189 A:A:M53 32.73046.22YesYes098
34A:A:F189 A:A:F196 32.89644.29YesNo097
35A:A:F196 A:A:L194 32.82178.53NoYes474
36A:A:N331 A:A:T324 32.83912.92YesYes489
37A:A:M53 A:A:V332 32.65613.04YesYes487
38A:A:N331 A:A:V332 32.85034.43YesYes487
39A:A:W211 B:B:Y145 27.244110.61YesYes198
40A:A:F191 A:A:V332 65.42629.18YesYes457
41A:A:F191 A:A:F336 65.27495.36YesYes458
42A:A:L194 R:R:V129 33.78155.96YesNo447
43A:A:F336 R:R:V129 65.22795.24YesNo487
44B:B:D186 B:B:Y145 22.0333.45YesYes198
45R:R:E130 R:R:V129 98.93478.56NoNo057
46R:R:D127 R:R:E130 98.865.2NoNo055
47R:R:D127 R:R:T126 98.785210.12NoNo056
48R:R:T126 R:R:Y122 98.710314.98NoYes068
49R:R:L200 R:R:Y122 98.41017.03YesYes068
50R:R:A118 R:R:L200 98.18433.15NoYes096
51R:R:A118 R:R:I197 98.10883.25NoNo098
52R:R:I197 R:R:Y201 98.03344.84NoYes089
53R:R:R121 R:R:Y201 43.2585.14YesYes099
54R:R:I117 R:R:R121 12.32115.01NoYes099
55R:R:I117 R:R:L65 12.12692.85NoYes099
56R:R:D69 R:R:L65 10.65744.07YesYes299
57R:R:D69 R:R:N41 22.09876.73YesNo099
58R:R:N41 R:R:P344 20.3626.52NoNo099
59R:R:I40 R:R:P344 19.92773.39NoNo089
60R:R:I40 R:R:L43 18.62482.85NoNo087
61R:R:L43 R:R:V44 18.19062.98NoNo079
62R:R:I48 R:R:V44 17.75773.07NoNo089
63R:R:F354 R:R:I48 16.1945.02YesNo088
64R:R:R121 R:R:Y347 29.91816.17YesYes099
65R:R:N343 R:R:Y347 32.2595.81YesYes299
66R:R:D69 R:R:N343 31.94626.73YesYes299
67R:R:I298 R:R:Y201 49.53088.46NoYes089
68R:R:I298 R:R:Y347 29.814513.3NoYes289
69R:R:I298 R:R:I346 19.62684.42NoYes288
70R:R:I346 R:R:N343 16.19222.83YesYes289
71B:B:D186 B:B:G185 13.75111.68YesNo095
72B:B:D205 B:B:G185 13.45721.68YesNo095
73B:B:D298 B:B:V40 21.86142.92NoNo093
74B:B:D298 B:B:R283 19.663510.72NoYes099
75B:B:L300 B:B:R283 10.09017.29YesYes569
76B:B:L51 B:B:W82 32.467610.25NoYes099
77B:B:I338 B:B:L51 32.70542.85NoNo059
78R:R:D69 R:R:S340 20.197610.31YesNo099
79R:R:S340 R:R:V72 19.76964.85NoYes097
80R:R:V72 R:R:V76 17.64263.21YesYes077
81R:R:L114 R:R:Y347 27.26967.03YesYes299
82R:R:V76 R:R:W99 12.33344.9YesYes076
83R:R:F302 R:R:L114 16.29624.87YesYes299
84R:R:F302 R:R:W306 10.51127.02YesYes299
85R:R:L114 R:R:N339 10.87262.75YesYes299
86R:R:N339 R:R:W306 26.18756.78YesYes299
87R:R:N339 R:R:N343 16.426310.9YesYes299
88L:L:?1 R:R:W306 22.59826.45YesYes209
89B:B:G77 B:B:K78 22.28943.49NoYes088
90B:B:G77 B:B:L95 22.04795.13NoYes088
91B:B:C114 B:B:L95 16.94413.17YesYes688
92B:B:C114 B:B:G115 16.75513.92YesNo089
93B:B:G115 B:B:L146 16.51093.42NoYes097
94B:B:L146 B:B:T159 10.84454.42YesYes979
95B:B:D228 B:B:S227 15.52352.94NoNo096
96B:B:D247 B:B:S227 15.23454.42YesNo096
97B:B:I338 G:G:F61 32.93813.77NoYes358
98B:B:I80 B:B:W82 24.56616.44YesYes389
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D103 R:R:V76 4.38 2 Yes Yes 8 7 1 2
R:R:M77 R:R:W334 9.31 2 Yes Yes 8 7 2 2
R:R:M77 R:R:Y337 3.59 2 Yes Yes 8 7 2 1
R:R:I174 R:R:L100 7.14 0 No No 5 6 1 2
R:R:C107 R:R:D103 3.11 2 No Yes 7 8 1 1
R:R:D103 R:R:Y337 10.34 2 Yes Yes 8 7 1 1
L:L:?1 R:R:D103 14.42 2 Yes Yes 0 8 0 1
R:R:I104 R:R:S155 7.74 0 No No 7 8 1 2
R:R:I104 R:R:P158 6.77 0 No No 7 7 1 2
L:L:?1 R:R:I104 10.11 2 Yes No 0 7 0 1
R:R:C107 R:R:W306 5.22 2 No Yes 7 9 1 1
L:L:?1 R:R:C107 10.12 2 Yes No 0 7 0 1
R:R:S151 R:R:T108 3.2 0 Yes No 8 8 2 1
R:R:I154 R:R:T108 6.08 0 No No 7 8 2 1
L:L:?1 R:R:T108 3.13 2 Yes No 0 8 0 1
R:R:A189 R:R:I154 3.25 0 No No 7 7 2 2
R:R:P158 R:R:S185 5.34 0 No No 7 7 2 1
R:R:F160 R:R:H176 9.05 0 No Yes 5 5 2 1
L:L:?1 R:R:I174 12.13 2 Yes No 0 5 0 1
R:R:K175 R:R:N317 2.8 0 No Yes 5 6 2 1
R:R:H176 R:R:H178 9.55 2 Yes No 5 4 1 2
R:R:H176 R:R:S181 5.58 2 Yes No 5 7 1 2
R:R:H176 R:R:T182 4.11 2 Yes No 5 7 1 1
L:L:?1 R:R:H176 7.29 2 Yes Yes 0 5 0 1
R:R:H178 R:R:S181 4.18 2 No No 4 7 2 2
R:R:T182 R:R:T186 3.14 2 No No 7 7 1 2
L:L:?1 R:R:T182 6.26 2 Yes No 0 7 0 1
L:L:?1 R:R:S185 3.19 2 Yes No 0 7 0 1
R:R:A189 R:R:F310 2.77 0 No Yes 7 6 2 1
R:R:F190 R:R:F302 7.5 2 Yes Yes 8 9 2 2
R:R:F190 R:R:W306 3.01 2 Yes Yes 8 9 2 1
R:R:F190 R:R:F310 15 2 Yes Yes 8 6 2 1
R:R:F302 R:R:W306 7.02 2 Yes Yes 9 9 2 1
R:R:F302 R:R:N339 4.83 2 Yes Yes 9 9 2 2
R:R:F309 R:R:W306 3.01 2 Yes Yes 7 9 1 1
R:R:F310 R:R:W306 6.01 2 Yes Yes 6 9 1 1
R:R:G336 R:R:W306 8.44 0 No Yes 7 9 2 1
R:R:N339 R:R:W306 6.78 2 Yes Yes 9 9 2 1
L:L:?1 R:R:W306 6.45 2 Yes Yes 0 9 0 1
R:R:F309 R:R:K312 6.2 2 Yes Yes 7 5 1 2
R:R:E313 R:R:F309 5.83 2 Yes Yes 6 7 1 1
R:R:F309 R:R:L332 3.65 2 Yes No 7 6 1 2
R:R:A333 R:R:F309 4.16 0 No Yes 5 7 2 1
L:L:?1 R:R:F309 12.08 2 Yes Yes 0 7 0 1
L:L:?1 R:R:F310 10.35 2 Yes Yes 0 6 0 1
R:R:E313 R:R:K312 4.05 2 Yes Yes 6 5 1 2
R:R:K312 R:R:V316 4.55 2 Yes Yes 5 4 2 2
R:R:K312 R:R:L332 5.64 2 Yes No 5 6 2 2
R:R:E313 R:R:N317 7.89 2 Yes Yes 6 6 1 1
L:L:?1 R:R:E313 11.26 2 Yes Yes 0 6 0 1
R:R:N317 R:R:V316 7.39 2 Yes Yes 6 4 1 2
L:L:?1 R:R:N317 9.73 2 Yes Yes 0 6 0 1
R:R:W334 R:R:Y337 3.86 2 Yes Yes 7 7 2 1
L:L:?1 R:R:Y337 6.64 2 Yes Yes 0 7 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
80.00Single6J21Aprepitant6J21-NK1-Aprepitant
73.33Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
73.33Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
71.43Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
70.59Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
68.75Single2YDVNECA2YDV-A2A-NECA
68.75Single4UHRCGS216804UHR-A2A-CGS21680
68.75Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
68.75Single5G53NECA5G53-A2A-NECA-Gs
68.75Single5V54Methiothepin5V54-5-HT1B-Methiothepin
68.75Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
68.75Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
68.75Consensus5ht1_offOrthosteric Ligand5ht1b_off
68.75Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
68.75Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
68.75Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
68.75Consensusa2_onOrthosteric Liganda2a_on a2b_on
66.67Single3NY8ICI 118-5513NY8-β2-ICI 118-551
66.67Single3NY9PubChem 9131033NY9-β2-PubChem 913103
66.67Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
66.67Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
66.67Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
66.67Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
66.67Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
66.67Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
66.67Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
66.67Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
66.67Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
64.71Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
64.71Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
64.71Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
64.71Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
64.29Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
63.16Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
62.50Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
62.50Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
62.50Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
62.50Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
62.50Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
62.50Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
62.50Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
62.50Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
62.50Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
61.11Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
61.11Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
61.11Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
61.11Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
61.11Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
61.11Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
60.00Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
60.00Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
60.00Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
60.00Single6PS4ICI 118-5516PS4-β2-ICI 118-551
60.00Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
60.00Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
60.00Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
60.00Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
60.00Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
60.00Single8GGQEpinephrine8GGQ-β2-Epinephrine
60.00Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
60.00Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
60.00Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
60.00Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
60.00Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
60.00Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
60.00Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
60.00Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
60.00Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
58.82Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
58.82Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
58.82Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
58.82Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
58.82Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
58.82Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
58.82Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
58.82Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
58.82Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
58.82Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
58.82Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
58.82Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
58.82Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
58.82Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
57.89Single4UG2CGS216804UG2-A2A-CGS21680
57.89Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
57.14Single3PBLEticlopride3PBL-D3-Eticlopride
57.14Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
57.14Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
57.14Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
57.14Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
57.14Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
56.25Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
56.25Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
56.25Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
56.25Single4EJ4Naltrindole4EJ4-δ-Naltrindole
56.25Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
56.25Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
56.25Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
56.25Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
56.25Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
56.25Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
56.25Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
56.25Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
56.25Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
56.25Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
56.25Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
56.25Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
56.25Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
56.25Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
56.25Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
56.25Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
56.25Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
56.25Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
56.25Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
56.25Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
56.25Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
56.25Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
56.25Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
56.25Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
56.25Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
56.25Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
56.25Single8GGJEpinephrine8GGJ-β2-Epinephrine
56.25Single8GGNEpinephrine8GGN-β2-Epinephrine
56.25Single8GGOEpinephrine8GGO-β2-Epinephrine
56.25Single8GGUEpinephrine8GGU-β2-Epinephrine
56.25Single8JJOAlprenolol8JJO-β2-Alprenolol
56.25Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
56.25Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
56.25Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
56.25Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
56.25Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
56.25Single8X64Desloratadine8X64-H1-Desloratadine
56.25Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
56.25Consensusadenosine_onOrthosteric Liganda1_on a2_on
56.25Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
56.25Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
56.25Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
56.25Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
56.25Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
56.25Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
56.25Consensusnucleotide_onOrthosteric Ligandadenosine_on
56.25Consensustar_onOrthosteric Ligandta1_on
55.56Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
55.56Single4AMIBucindolol4AMI-β1-Bucindolol
55.56Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
55.56Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
55.56Single6HLPNetupitant6HLP-NK1-Netupitant
55.56Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
55.56Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
55.56Single7YITNalfurafine7YIT-κ-Nalfurafine
55.56Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
55.56Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
55.56Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
55.00Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
54.55Single7C61Ergotamine7C61-5-HT1B-Ergotamine
53.33Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
53.33Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
53.33Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
53.33Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
53.33Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
53.33Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
53.33Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
53.33Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
53.33Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
53.33Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
53.33Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
53.33Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
53.33Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
53.33Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
53.33Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.33Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.33Single8GGVEpinephrine8GGV-β2-Epinephrine
53.33Single8GGXEpinephrine8GGX-β2-Epinephrine
53.33Single8GH0Epinephrine8GH0-β2-Epinephrine
53.33Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
53.33Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.33Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
53.33Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
53.33Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
53.33Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
53.33Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
53.33Consensusalpha1_onOrthosteric Ligandalpha1a_on
53.33Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
53.33Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
53.33Consensusgt_class-aOrthosteric Ligandgt_opsin
53.33Consensusgt_opsinOrthosteric Ligandgt_sensory
53.33Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
53.33Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
52.94Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
52.94Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
52.94Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
52.94Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
52.94Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
52.94Single6PS6Timolol6PS6-β2-Timolol
52.94Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
52.94Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
52.94Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
52.94Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
52.94Single7WC6LSD7WC6-5-HT2A-LSD
52.94Single7XKAEpinephrine7XKA-β2-Epinephrine
52.94Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
52.94Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
52.94Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
52.94Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
52.94Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
52.94Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
52.94Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
52.94Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
52.94Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
52.94Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
52.63Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
52.63Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
52.63Single7UM4AS26747237UM4-5-HT5A-AS2674723
52.63Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
52.63Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
52.38Single3QAKUK-4320973QAK-A2A-UK-432097
52.38Single6HLOAprepitant6HLO-NK1-Aprepitant
52.17Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
50.00Single2YDOAdenosine2YDO-A2A-Adenosine
50.00Single3RZECidoxepin3RZE-H1-Cidoxepin
50.00Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
50.00Single4U15Tiotropium4U15-M3-Tiotropium
50.00Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
50.00Single5WF5UK-4320975WF5-A2A-UK-432097
50.00Single6A94Zotepine6A94-5-HT2A-Zotepine
50.00Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
50.00Single6H7JIsoprenaline6H7J-β1-Isoprenaline
50.00Single6J20Aprepitant6J20-NK1-Aprepitant
50.00Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
50.00Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
50.00Single6OL9Tiotropium6OL9-M5-Tiotropium
50.00Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
50.00Single6PS5(S)-Propranolol6PS5-β2-(S)-Propranolol
50.00Single6PT3DPI-2876PT3-δ-DPI-287
50.00Single6TPNHTL66416TPN-OX2-HTL6641
50.00Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
50.00Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
50.00Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
50.00Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
50.00Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
50.00Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
50.00Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
50.00Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
50.00Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
50.00Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
50.00Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
50.00Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
50.00Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
50.00Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8GGIEpinephrine8GGI-β2-Epinephrine
50.00Single8GGKEpinephrine8GGK-β2-Epinephrine
50.00Single8GGLEpinephrine8GGL-β2-Epinephrine
50.00Single8GGMEpinephrine8GGM-β2-Epinephrine
50.00Single8GGPEpinephrine8GGP-β2-Epinephrine
50.00Single8GGTEpinephrine8GGT-β2-Epinephrine
50.00Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
50.00Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
50.00Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
50.00Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
50.00Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
50.00Consensus5ht5_offOrthosteric Ligand5ht5a_off
50.00Consensus5ht5_onOrthosteric Ligand5ht5a_on
50.00Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
50.00Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
50.00Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
50.00Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
50.00Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
50.00Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
50.00Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
50.00Consensushistamine_offOrthosteric Ligandh1_off
50.00Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
50.00Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
50.00Consensussensory_offOrthosteric Ligandopsin_off
50.00Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
47.83Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
47.62Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
47.62Single4IARErgotamine4IAR-5-HT1B-Ergotamine
47.62Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
47.62Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
47.37Single4LDEBI1671074LDE-β2-BI167107
47.37Single5CXVTiotropium5CXV-M1-Tiotropium
47.37Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
47.37Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
47.37Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
47.37Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
47.37Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
47.37Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
47.37Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
47.37Single8JJ8Formoterol8JJ8-β2-Formoterol
47.37Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
47.37Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
47.37Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
47.37Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
47.06Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
47.06Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
47.06Single2Y04Salbutamol2Y04-β1-Salbutamol
47.06Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
47.06Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
47.06Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
47.06Single6H7MSalbutamol6H7M-β1-Salbutamol
47.06Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
47.06Single6PS1Timolol6PS1-β2-Timolol
47.06Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
47.06Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
47.06Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
47.06Single7WC7Lisuride7WC7-5-HT2A-Lisuride
47.06Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
47.06Single8CU6LJ-45178CU6-A2A-LJ-4517
47.06Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
47.06Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
47.06Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
47.06Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
47.06Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
47.06Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
47.06Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
47.06Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
47.06Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
47.06Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
47.06Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
47.06Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
47.06Consensustachykinin_offOrthosteric Ligandnk1_off
46.67Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
46.67Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
46.67Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
46.67Single6HLLCP999946HLL-NK1-CP99994
46.67Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
46.67Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
46.67Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
46.67Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
46.67Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
46.67Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
46.67Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
46.67Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
46.67Single8GGSEpinephrine8GGS-β2-Epinephrine
46.67Single8GGYEpinephrine8GGY-β2-Epinephrine
46.67Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
46.67Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.67Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
46.67Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
46.67Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
46.67Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
46.67Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
46.67Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
46.67Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
45.45Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
45.45Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
45.00Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
45.00Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
45.00Single6H7LDobutamine6H7L-β1-Dobutamine
45.00Single6IBLArformoterol6IBL-β1-Arformoterol
45.00Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
45.00Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
45.00Single7EZCUKA7EZC-A2A-UKA
45.00Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
45.00Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
45.00Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
45.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
45.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
45.00Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
45.00Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
45.00Consensusendothelin_offOrthosteric Ligandetb_off
45.00Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
45.00Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
45.00Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
44.44Single2Y03Isoprenaline2Y03-β1-Isoprenaline
44.44Single5C1MBU725C1M-μ-BU72
44.44Single5NM2ZM2413855NM2-A2A-ZM241385-Na
44.44Single5TVNLSD5TVN-5-HT2B-LSD
44.44Single5WIUNemonapride5WIU-D4-Nemonapride
44.44Single5WIVNemonapride5WIV-D4-Nemonapride-Na
44.44Single6E67BI1671076E67-β2-BI167107-Gs (fused)
44.44Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
44.44Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
44.44Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
44.44Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
44.44Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
44.44Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
44.44Single8QOTNanobody E8QOT-μ-Nanobody E
44.44Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
44.44Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
44.44Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
44.44Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
44.44Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
44.44Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
44.44Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
44.44Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
44.44Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
43.75Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
43.75Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
43.75Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
43.75Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
43.75Single6B73PubChem 1319551386B73-κ-PubChem 131955138
43.75Single6KUXRS-799486KUX-α2a-RS-79948
43.75Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
43.75Single6ME2Ramelteon6ME2-MT1-Ramelteon
43.75Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
43.75Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
43.75Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
43.75Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
43.75Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
43.75Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
43.75Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
43.75Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
43.75Single8GGWEpinephrine8GGW-β2-Epinephrine
43.75Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
43.75Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
43.75Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
43.75Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
43.75Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
43.75Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
43.75Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
43.75Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
43.75Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
43.75Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
43.75Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
43.48Single6PT2KGCHM076PT2-δ-KGCHM07
43.48Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
43.48Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
42.86Single5WF6UK-4320975WF6-A2A-UK-432097
42.86Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
42.86Single7SK9CCX6627SK9-ACKR3-CCX662
42.86Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
42.86Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
42.86Single8X5YAstemizole8X5Y-H1-Astemizole
42.86Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
42.86Consensussensory_onOrthosteric Ligandopsin_on
42.11Single3P0GBI1671073P0G-β2-BI167107
42.11Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
42.11Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
42.11Single4RWADIPP-NH24RWA-δ-DIPP-NH2
42.11Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
42.11Single5X93K-87945X93-ETB-K-8794
42.11Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
42.11Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
42.11Single6E59L-7607356E59-NK1-L-760735
42.11Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
42.11Single6TQ7SB-3348676TQ7-OX1-SB-334867
42.11Single6WGTLSD6WGT-5-HT2A-LSD
42.11Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
42.11Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
42.11Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
42.11Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
42.11Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
42.11Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
42.11Single8E0GBU728E0G-μ-BU72
42.11Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
42.11Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
42.11Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
42.11Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
42.11Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
42.11Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
42.11Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
42.11Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
42.11Consensusadenosine_offOrthosteric Liganda1_off a2_off
42.11Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
42.11Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
42.11Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
42.11Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
42.11Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
41.67Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
41.18Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
41.18Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
41.18Single5IU7Q274563465IU7-A2A-Q27456346-Na
41.18Single5JTBZM2413855JTB-A2A-ZM241385
41.18Single5UVIZM2413855UVI-A2A-ZM241385
41.18Single6AQFZM2413856AQF-A2A-ZM241385
41.18Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
41.18Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
41.18Single6TPGEMPA6TPG-OX2-EMPA
41.18Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
41.18Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
41.18Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
41.18Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
41.18Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
41.18Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
41.18Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
41.18Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
41.18Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
41.18Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
40.91Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
40.91Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
40.91Consensussst_onOrthosteric Ligandsst2_on sst4_on
40.00Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
40.00Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
40.00Single3UZAGTPL92363UZA-A2A-GTPL9236
40.00Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
40.00Single6MXTSalmeterol6MXT-β2-Salmeterol
40.00Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
40.00Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
40.00Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
40.00Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
40.00Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
40.00Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
40.00Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
40.00Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
40.00Single8GGREpinephrine8GGR-β2-Epinephrine
40.00Single8GGZEpinephrine8GGZ-β2-Epinephrine
40.00Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
40.00Single8JJLOlodaterol8JJL-β2-Olodaterol
40.00Single8JWZAB9288JWZ-A2A-AB928-Na
40.00Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
40.00Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
40.00Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
40.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
40.00Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
40.00Consensusgs_steroidOrthosteric Ligandgs_bileacid
40.00Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
40.00Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
39.13Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
38.89Single2Y01Dobutamine2Y01-β1-Dobutamine
38.89Single2Y02Carmoterol2Y02-β1-Carmoterol
38.89Single3EMLZM2413853EML-A2A-ZM241385
38.89Single4EIYZM2413854EIY-A2A-ZM241385-Na
38.89Single4MQSIperoxo4MQS-M2-Iperoxo
38.89Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
38.89Single4U14Tiotropium4U14-M3-Tiotropium
38.89Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
38.89Single5IU8Q274563475IU8-A2A-Q27456347-Na
38.89Single5K2AZM2413855K2A-A2A-ZM241385-Na
38.89Single5OLGZM2413855OLG-A2A-ZM241385-Na
38.89Single5VRAZM2413855VRA-A2A-ZM241385-Na
38.89Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
38.89Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
38.89Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
38.89Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
38.89Single6S0LZM2413856S0L-A2A-ZM241385
38.89Single7BU7BI1671077BU7-β1-BI167107
38.89Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
38.89Single7PYRPSB-21157PYR-A2A-PSB-2115
38.89Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
38.89Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
38.89Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
38.89Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
38.89Single7UL4Alvimopan7UL4-μ-Alvimopan
38.89Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
38.89Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
38.89Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
38.89Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
38.89Single8X63Mepyramine8X63-H1-Mepyramine
38.89Consensusa2_offOrthosteric Liganda2a_off
38.89Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
38.89Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
38.89Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
38.89Consensushistamine_onOrthosteric Ligandh1_on h4_on
38.89Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
38.89Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
38.89Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
38.10Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
38.10Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
38.10Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
38.10Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
38.10Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
38.10Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
38.10Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
38.10Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
38.10Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
38.10Consensussteroid_onOrthosteric Ligandbileacid_on
37.50Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
37.50Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
37.50Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
37.50Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
37.50Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
37.50Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
37.50Single7SRQLSD7SRQ-5-HT2B-LSD
37.50Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
37.50Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
37.50Single8GH1Epinephrine8GH1-β2-Epinephrine
37.50Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
37.50Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
37.50Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
37.50Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
37.04Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
36.84Single2Y00Dobutamine2Y00-β1-Dobutamine
36.84Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
36.84Single5IUAQ274563485IUA-A2A-Q27456348-Na
36.84Single5N2SPSB365N2S-A1-PSB36
36.84Single5WQCEMPA5WQC-OX2-EMPA
36.84Single5XPRBosentan5XPR-ETB-Bosentan
36.84Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
36.84Single6LPLZM2413856LPL-A2A-ZM241385-Na
36.84Single6LUQHaloperidol6LUQ-D2-Haloperidol
36.84Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
36.84Single6S0QZM2413856S0Q-A2A-ZM241385
36.84Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
36.84Single6WQAZM2413856WQA-A2A-ZM241385-Na
36.84Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
36.84Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
36.84Single7RM5ZM2413857RM5-A2A-ZM241385-Na
36.84Single7SINNPS-21437SIN-CaS-NPS-2143
36.84Single7SINNPS-21437SIN-CaS-NPS-2143
36.84Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
36.84Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
36.84Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
36.84Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
36.84Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
36.84Single8FYNZM2413858FYN-A2A-ZM241385-Na
36.84Single8GNEKW-63568GNE-A2A-KW-6356-Na
36.84Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
36.84Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
36.84Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
36.84Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
36.84Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
36.84Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
36.84Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
36.84Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
36.84Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
36.84Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
36.36Single5ZTYAM102575ZTY-CB2-AM10257
36.36Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
36.36Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
36.36Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
36.36Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
36.36Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
36.00Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
36.00Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
35.71Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
35.71Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
35.71Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
35.29Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
35.29Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
35.29Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
35.29Single5DHHSB-6121115DHH-NOP-SB-612111
35.29Single5K2DZM2413855K2D-A2A-ZM241385
35.29Single6AKXA4R6AKX-CCR5-A4R
35.29Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
35.29Single6JZHZM2413856JZH-A2A-ZM241385-Na
35.29Single6PS7ZM2413856PS7-A2A-ZM241385-Na
35.29Single6TODEMPA6TOD-OX1-EMPA-Na
35.29Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
35.29Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
35.29Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
35.29Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
35.29Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
35.29Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
35.29Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
35.29Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
35.29Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
35.29Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
35.29Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
35.29Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
35.29Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
35.29Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
35.29Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
35.29Single8IWESpermidine8IWE-TAAR9-Spermidine
35.29Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
35.29Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
35.29Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
35.29Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
35.29Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
35.29Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.29Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.29Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
35.29Consensusmglu_onOther Ligandmglu2_on mglu4_on
35.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
35.00Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
35.00Single4DJHJDTic4DJH-κ-JDTic
35.00Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
35.00Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
35.00Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
35.00Single7PX4PSB-21137PX4-A2A-PSB-2113
35.00Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
35.00Single7TUYGSK682753A7TUY-GPR183-GSK682753A
35.00Single7W41PD1762527W41-BB2-PD176252
35.00Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
35.00Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
35.00Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
35.00Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
35.00Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
35.00Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
35.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
35.00Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
35.00Consensusbombesin_offOrthosteric Ligandbb2_off
35.00Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
35.00Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
35.00Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
35.00Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
34.78Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
34.78Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
34.78Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
34.78Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
34.78Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
34.78Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
34.78Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
34.48Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
34.48Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
33.33Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
33.33Single4MBSMaraviroc4MBS-CCR5-Maraviroc
33.33Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
33.33Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
33.33Single4ZJCSB-6740424ZJC-OX1-SB-674042
33.33Single5IU4ZM2413855IU4-A2A-ZM241385-Na
33.33Single5IUBQ274563445IUB-A2A-Q27456344-Na
33.33Single5K2BZM2413855K2B-A2A-ZM241385-Na
33.33Single5K2CZM2413855K2C-A2A-ZM241385-Na
33.33Single5NLXZM2413855NLX-A2A-ZM241385-Na
33.33Single5NM4ZM2413855NM4-A2A-ZM241385-Na
33.33Single6A93Risperidone6A93-5-HT2A-Risperidone
33.33Single6CM4Risperidone6CM4-D2-Risperidone
33.33Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
33.33Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
33.33Single6IQLL7458706IQL-D4-L745870
33.33Single6MH8ZM2413856MH8-A2A-ZM241385
33.33Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
33.33Single6TPKRetosiban6TPK-OT-Retosiban
33.33Single6VI4JDTic6VI4-κ-JDTic
33.33Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
33.33Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
33.33Single6ZG4HTL00099366ZG4-M1-HTL0009936
33.33Single7AROLUF58337ARO-A2A-LUF5833-Na
33.33Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
33.33Single7DFPSpiperone7DFP-D2-Spiperone
33.33Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
33.33Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
33.33Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
33.33Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
33.33Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
33.33Single7T32ZM2413857T32-A2A-ZM241385
33.33Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
33.33Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
33.33Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
33.33Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
33.33Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
33.33Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
33.33Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
33.33Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
33.33Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
33.33Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
33.33Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
33.33Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
33.33Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
33.33Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
33.33Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
33.33Single8WU1KCA8WU1-CB1-KCA-Arrestin1
33.33Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
33.33Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
33.33Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
33.33Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
33.33Consensusgi_class-fOther Ligandgi_frizzled
33.33Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
33.33Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
33.33Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
33.33Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
33.33Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
33.33Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
33.33Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
33.33Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
33.33Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
33.33Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
33.33Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
33.33Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
33.33Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
33.33Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
33.33Consensusvasopressin-ot_offOrthosteric Ligandot_off
32.00Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
32.00Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
32.00Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
32.00Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
32.00Consensusangiotensin_onOrthosteric Ligandat1_on
32.00Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
31.82Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
31.82Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
31.82Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
31.82Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
31.82Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
31.82Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
31.82Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
31.82Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
31.82Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
31.82Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
31.82Consensuscyslt_offOrthosteric Ligandcyslt2_off
31.58Single4DAJTiotropium4DAJ-M3-Tiotropium
31.58Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
31.58Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
31.58Single5DSGTiotropium5DSG-M4-Tiotropium
31.58Single5UENDU1725UEN-A1-DU172
31.58Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
31.58Single6DRXLisuride6DRX-5-HT2B-Lisuride
31.58Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
31.58Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
31.58Single6LPJZM2413856LPJ-A2A-ZM241385-Na
31.58Single6LPKZM2413856LPK-A2A-ZM241385-Na
31.58Single6TOTLemborexant6TOT-OX1-Lemborexant
31.58Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
31.58Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
31.58Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
31.58Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
31.58Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
31.58Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
31.58Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
31.58Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
31.58Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
31.58Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
31.58Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
31.58Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
31.58Consensusblt_onOrthosteric Ligandblt1_on
31.58Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
31.58Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
31.58Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
31.58Consensusgi_hcarOrthosteric Ligandgi_hca
31.58Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
31.58Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
31.58Consensusleuko_onOrthosteric Ligandblt_on
31.58Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
31.58Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
31.25Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
31.25Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
31.25Single6ME5Agomelatine6ME5-MT1-Agomelatine
31.25Single6ME9Ramelteon6ME9-MT2-Ramelteon
31.25Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.25Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
31.25Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
31.25Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
31.25Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
31.25Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
31.25Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
31.25Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
31.03Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
30.77Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
30.77Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
30.77Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
30.77Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
30.77Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
30.77Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
30.77Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
30.77Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
30.43Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
30.43Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
30.43Single7XN9L-054,5227XN9-SST2-L-054,522
30.43Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
30.43Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
30.43Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
30.43Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
30.43Consensuslpl_offOrthosteric Ligands1p_off lpa_off
30.43Consensuslpl_onOrthosteric Ligands1p_on lpa_on
30.43Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
30.00Single4NTJAZD12834NTJ-P2Y12-AZD1283
30.00Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
30.00Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
30.00Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
30.00Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
30.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
30.00Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
30.00Single6TP6Filorexant6TP6-OX1-Filorexant
30.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
30.00Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
30.00Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
30.00Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Single8EA0Iperoxo8EA0-M3-Iperoxo
30.00Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
30.00Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
30.00Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
30.00Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.63Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
29.63Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
29.63Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
29.63Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
29.63Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
29.63Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
29.41Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
29.41Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
29.41Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
29.41Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
29.41Single6TP4ACT-4622066TP4-OX1-ACT-462206
29.41Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
29.41Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.41Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.41Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
29.41Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.41Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
29.41Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
29.41Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
29.41Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
29.41Single8K5BNiacin8K5B-HCA2-Niacin
29.41Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
29.41Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
29.17Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
29.17Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
29.17Single7F8XNN90567F8X-CCKA-NN9056
29.17Single7QA8Peptide7QA8-STE2-Peptide
29.17Single7QA8Peptide7QA8-STE2-Peptide
29.17Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
29.17Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
29.17Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
29.17Consensusclass-d_offOrthosteric Ligandste2_off
29.17Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
29.17Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
28.57Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
28.57Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
28.57Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
28.57Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
28.57Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
28.57Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
28.57Single7B6WCyclazosin7B6W-α1b-Cyclazosin
28.57Single7EPENAM5637EPE-mGlu-NAM563
28.57Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
28.57Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
28.57Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
28.57Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
28.57Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
28.57Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
28.57Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
28.57Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
28.57Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
28.57Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
28.57Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
28.57Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
28.57Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
28.57Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Consensuslpa_offOrthosteric Ligandlpa1_off
28.57Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
28.57Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
28.57Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
28.57Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
28.57Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
28.00Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
28.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
28.00Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
28.00Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
27.78Single3PWHZM2413853PWH-A2A-ZM241385
27.78Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
27.78Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
27.78Single5WS3EMPA5WS3-OX2-EMPA
27.78Single6AKYMaraviroc6AKY-CCR5-Maraviroc
27.78Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
27.78Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
27.78Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
27.78Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
27.78Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
27.78Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
27.78Single8GNGIstradefylline8GNG-A2A-Istradefylline
27.78Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
27.78Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
27.78Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
27.78Consensusorexin_offOrthosteric Ligandox2_off ox1_off
27.59Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
27.59Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
27.59Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
27.59Consensusendothelin_onOrthosteric Ligandetb_on eta_on
27.59Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
27.27Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
27.27Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
27.27Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
27.27Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
27.27Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
27.27Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
27.27Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
27.27Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
27.27Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
27.27Consensusclass-b2_onOrthosteric Ligandadgrg_on
27.27Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
27.27Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
27.27Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
27.27Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
26.92Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
26.92Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
26.67Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
26.67Single6IGLIRL16206IGL-ETB-IRL1620
26.67Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
26.67Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
26.67Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
26.67Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
26.67Single8PWNTheophylline8PWN-A2A-Theophylline
26.67Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
26.67Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
26.67Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.67Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
26.32Single3REYPubChem 56973REY-A2A-PubChem 5697
26.32Single6DS0Ly2660976DS0-5-HT2B-Ly266097
26.32Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
26.32Single6V9SGTPL114036V9S-OX1-GTPL11403
26.32Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
26.32Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
26.32Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
26.32Single7VODCariprazine7VOD-5-HT2A-Cariprazine
26.32Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
26.32Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
26.32Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
26.32Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
26.32Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
26.32Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
26.32Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
26.32Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
26.32Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
26.32Single8K5CAcipimox8K5C-HCA2-Acipimox
26.32Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.32Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
26.32Consensushca_onOrthosteric Ligandhca2_on hca3_on
26.32Consensushcar_onOrthosteric Ligandhca_on
26.09Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
26.09Single6K1QIRL25006K1Q-ETB-IRL2500
26.09Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
26.09Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
26.09Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
26.09Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
26.09Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
26.09Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.09Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
26.09Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
26.09Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
26.09Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
26.09Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.09Consensusorexin_onOrthosteric Ligandox2_on
25.93Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
25.93Single6JODAngiotensin II6JOD-AT2-Angiotensin II
25.93Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.93Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
25.81Single5GLHEndothelin-15GLH-ETB-Endothelin-1
25.81Single6IGKEndothelin-36IGK-ETB-Endothelin-3
25.00Single3RFMCaffeine3RFM-A2A-Caffeine
25.00Single5TGZAM65385TGZ-CB1-AM6538
25.00Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
25.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
25.00Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
25.00Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
25.00Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
25.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
25.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
25.00Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
25.00Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
25.00Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
25.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
25.00Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
25.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
25.00Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
25.00Single8A2OTheophylline8A2O-A2A-Theophylline-Na
25.00Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
25.00Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
25.00Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
25.00Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
25.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
25.00Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
25.00Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
25.00Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
25.00Consensusclass-d_offOrthosteric Ligandste2_off
25.00Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
25.00Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
25.00Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
24.24Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
24.14Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
24.14Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
24.14Consensusclass-d_onOrthosteric Ligandste2_on
24.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
24.00Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
24.00Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
24.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
24.00Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
24.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
24.00Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
23.81Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
23.81Single5CGCHTL142425CGC-mGlu5-HTL14242
23.81Single6D26Fevipiprant6D26-DP2-Fevipiprant
23.81Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
23.81Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
23.81Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
23.81Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
23.81Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
23.81Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
23.81Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
23.81Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
23.81Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
23.81Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
23.81Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
23.81Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
23.81Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
23.81Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
23.81Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
23.81Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
23.81Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
23.53Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
23.53Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
23.53Single7WC5Psilocin7WC5-5-HT2A-Psilocin
23.53Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
23.53Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
23.53Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
23.33Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
23.33Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.33Consensusgi_class-dOrthosteric Ligandgi_ste
23.33Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
23.33Consensusgo_class-b1Orthosteric Ligandgo_crf
23.33Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
23.08Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
23.08Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
23.08Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
23.08Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
23.08Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
22.73Single5TZR-5TZR-FFA1 (GPR40)-MK8666
22.73Single5XR8AM8415XR8-CB1-AM841
22.73Single5XRAAM115425XRA-CB1-AM11542
22.73Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
22.73Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
22.73Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
22.73Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
22.73Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
22.73Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
22.73Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
22.73Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
22.73Consensuscck_onOrthosteric Ligandccka_on cckb_on
22.73Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
22.73Consensuslpa_onOrthosteric Ligandlpa1_on
22.73Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
22.73Consensusrelaxin_onOrthosteric Ligandrxfp4_on
22.58Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
22.58Single8IY6Endothelin-18IY6-ETB-Endothelin-1
22.58Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
22.22Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
22.22Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
22.22Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
22.22Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
22.22Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
22.22Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
22.22Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
22.22Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
21.88Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
21.88Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
21.74Single4N4WSANT-14N4W-SMO-SANT-1
21.74Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
21.74Single7K15MKD0467K15-BLT1-MKD046-Na
21.74Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
21.74Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
21.74Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
21.74Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
21.74Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
21.74Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
21.74Consensusblt_offOrthosteric Ligandblt1_off
21.74Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
21.74Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
21.74Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
21.74Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
21.74Consensusdp_offOrthosteric Liganddp2_off
21.74Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
21.74Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
21.43Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
21.43Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
21.43Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
21.43Consensusclass-d_onOrthosteric Ligandste2_on
21.43Consensusgi_class-dOrthosteric Ligandgi_ste
21.43Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
21.21Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
21.05Single4S0VSuvorexant4S0V-OX2-Suvorexant
21.05Single6TPJSuvorexant6TPJ-OX2-Suvorexant
21.05Single7F8ULintitript7F8U-CCKA-Lintitript
21.05Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
21.05Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
21.05Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
21.05Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
21.05Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
21.05Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
21.05Single7XRRLemborexant7XRR-OX2-Lemborexant
21.05Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
21.05Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
21.05Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
21.05Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
20.83Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
20.83Single5CGDHTL142425CGD-mGlu5-HTL14242
20.83Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
20.83Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
20.83Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
20.83Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.83Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
20.83Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.69Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
20.69Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
20.69Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
20.69Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
20.69Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
20.69Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
20.69Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
20.59Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
20.00Single5EE7MK08935EE7-Glucagon-MK0893
20.00Single5MZPCaffeine5MZP-A2A-Caffeine-Na
20.00Single6FFIMMPEP6FFI-mGlu5-MMPEP
20.00Single6TP3Nemorexant6TP3-OX1-Nemorexant
20.00Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
20.00Single6ZG9GSK10347026ZG9-M1-GSK1034702
20.00Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
20.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
20.00Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
20.00Single7VV6C48/807VV6-MRGPRX2-C48/80
20.00Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
20.00Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
20.00Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
20.00Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
20.00Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
20.00Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
20.00Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
20.00Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
20.00Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
20.00Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
20.00Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
20.00Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
20.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
20.00Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Consensusgs_class-b2Orthosteric Ligandgs_adgr
20.00Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
19.44Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
19.35Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
19.35Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
19.35Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
19.23Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
19.23Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
19.23Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
19.05Single4YAYZD-71554YAY-AT1-ZD-7155
19.05Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
19.05Single6FFHFenobam6FFH-mGlu5-Fenobam
19.05Single6IIVDaltroban6IIV-TP-Daltroban
19.05Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
19.05Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
19.05Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
19.05Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
19.05Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
19.05Single8K5DGSK2560738K5D-HCA2-GSK256073
19.05Consensuscck_offOrthosteric Ligandccka_off
19.05Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
19.05Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
19.05Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
19.05Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
19.05Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
18.75Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
18.75Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
18.75Single7WC4Serotonin7WC4-5-HT2A-Serotonin
18.75Consensusclass-c_onOther Ligandgabab_on mglu_on
18.75Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
18.52Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
18.52Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
18.52Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
18.52Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
18.52Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
18.52Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
18.52Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
18.52Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
18.18Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
18.18Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
18.18Single7C4SS1P7C4S-S1P3-S1P
18.18Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
18.18Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
18.18Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
18.18Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
18.18Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
18.18Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
18.18Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
17.86Single3OE0CVX153OE0-CXCR4-CVX15
17.86Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
17.86Single6W25SHU91196W25-MC4-SHU9119-Ca
17.86Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
17.86Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
17.86Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
17.86Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
17.65Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
17.65Single6TQ9SB-4081246TQ9-OX1-SB-408124
17.65Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
17.39Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
17.39Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
17.39Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
17.39Single7P2L4YI7P2L-mGlu5-4YI
17.39Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
17.39Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
17.39Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
17.39Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
17.39Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.39Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
17.39Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
17.39Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
17.39Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
17.39Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
17.39Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
17.24Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
17.24Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
17.24Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
17.24Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
17.24Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
16.67Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
16.67Single4PY02MeSATP4PY0-P2Y12-2MeSATP
16.67Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
16.67Single6IIURamatroban6IIU-TP-Ramatroban
16.67Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
16.67Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
16.67Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.67Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
16.67Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
16.67Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
16.67Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
16.67Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
16.67Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
16.67Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
16.67Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
16.67Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
16.67Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
16.67Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
16.67Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
16.67Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
16.67Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
16.67Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
16.67Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
16.67Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
16.22Consensuspth_onOrthosteric Ligandpth1_on pth2_on
16.13Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
16.13Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
16.13Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
16.13Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
16.13Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
16.13Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
16.13Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
16.13Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
16.13Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
16.13Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
16.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
16.00Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
16.00Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
15.79Single3OE9IT1t3OE9-CXCR4-IT1t
15.79Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
15.79Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
15.79Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.79Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
15.79Consensusgo_class-b2Orthosteric Ligandgo_adhesion
15.62Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
15.62Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
15.62Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
15.62Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
15.62Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
15.62Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
15.38Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
15.38Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
15.38Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
15.38Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
15.38Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
15.38Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
15.38Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
15.38Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
15.38Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
15.15Single6LMLGlucagon6LML-Glucagon-Glucagon
15.15Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
15.15Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
15.15Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
15.15Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
15.15Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
15.00Single5ZKQABT-4915ZKQ-PAF-ABT-491
15.00Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
15.00Single7BR3Elagolix7BR3-GnRH1-Elagolix
15.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
15.00Single8IHKAcifran8IHK-HCA3-Acifran
15.00Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
15.00Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
14.81Single4XT1Fractalkine4XT1-US28-Fractalkine
14.81Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
14.81Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
14.81Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
14.81Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
14.71Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
14.71Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
14.29Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
14.29Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
14.29Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
14.29Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
14.29Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
14.29Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
14.29Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
14.29Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
14.29Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
14.29Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
14.29Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
14.29Consensusglp_onOrthosteric Ligandglp1_on glp2_on
14.29Consensusgnrh_offOrthosteric Ligandgnrh1_off
14.29Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
14.29Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
14.29Consensuss1p_offOrthosteric Ligands1p1_off
13.89Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
13.89Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
13.89Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
13.79Single7XNACYN1548067XNA-SST2-CYN154806
13.79Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
13.79Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
13.79Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.79Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
13.79Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
13.79Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
13.64Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
13.64Single6D27CAY104716D27-DP2-CAY10471
13.64Single6GPSMK08126GPS-CCR2-MK0812
13.64Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
13.64Single7F83PF-051904577F83-Ghrelin-PF-05190457
13.64Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
13.64Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
13.64Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
13.64Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
13.51Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
13.51Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
13.51Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
13.33Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
13.33Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
13.33Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
13.33Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
13.33Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.33Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
13.33Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
13.33Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.16Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
13.04Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
13.04Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
13.04Single6GPXMK08126GPX-CCR2-MK0812
13.04Single7YXAONO-54306087YXA-S1P5-ONO-5430608
13.04Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
13.04Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
13.04Consensusep_offOrthosteric Ligandep4_off
12.90Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
12.90Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
12.90Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single4XT3Fractalkine4XT3-US28-Fractalkine
12.50Single5V56TC1145V56-SMO-TC114
12.50Single6FJ3PTH6FJ3-PTH1-PTH
12.50Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
12.50Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
12.50Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
12.50Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
12.50Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
12.50Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
12.50Single7F1TMIP-1a7F1T-CCR5-MIP-1a
12.50Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
12.50Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
12.50Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
12.50Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
12.50Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Consensuschemerin_onOrthosteric Ligandcml1_on
12.50Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
12.50Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
12.20Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
12.12Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
12.12Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
12.12Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
12.12Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
12.12Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
12.12Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
12.00Single4XEENeurotensin4XEE-NTS1-Neurotensin
12.00Single4XESNeurotensin4XES-NTS1-Neurotensin
12.00Single5X33BIIL2605X33-BLT1-BIIL260
12.00Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
12.00Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
12.00Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
12.00Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
12.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
12.00Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
12.00Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
12.00Consensusnts_offOrthosteric Ligandnts1_off
12.00Consensusnts_onOrthosteric Ligandnts1_on
11.90Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
11.76Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
11.76Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
11.76Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
11.76Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
11.76Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
11.76Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
11.76Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
11.76Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
11.54Single4BUONeurotensin4BUO-NTS1-Neurotensin
11.54Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
11.54Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
11.54Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
11.54Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
11.54Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
11.54Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
11.54Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
11.54Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
11.43Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
11.11Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.11Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
11.11Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
11.11Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
11.11Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
11.11Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
10.81Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
10.81Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
10.81Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
10.71Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
10.71Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
10.71Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.71Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
10.53Single3OE6IT1t3OE6-CXCR4-IT1t
10.53Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
10.53Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
10.53Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
10.53Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
10.53Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
10.53Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
10.53Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
10.34Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
10.34Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
10.34Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.34Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.34Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.34Consensussst_offOrthosteric Ligandsst2_off
10.26Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
10.00Single5L7IVismodegib5L7I-SMO-Vismodegib
10.00Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
10.00Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
10.00Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
10.00Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
10.00Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
10.00Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
10.00Consensusclass-t_onOrthosteric Ligandtaste2_on
10.00Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
10.00Consensusgs_class-tOrthosteric Ligandgs_taste
10.00Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
10.00Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
9.76Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
9.68Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
9.68Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
9.68Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
9.52Single3ODUIT1t3ODU-CXCR4-IT1t
9.52Single5U09Taranabant5U09-CB1-Taranabant
9.52Single7F8YDevazepide7F8Y-CCKA-Devazepide
9.52Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
9.52Single8DWHCompound-168DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.52Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
9.52Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
9.52Consensusclass-f_offOrthosteric Ligandsmo_off
9.52Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
9.38Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
9.38Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
9.38Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
9.09Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
9.09Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
9.09Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
9.09Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
9.09Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Single8IYXYL-3658IYX-GPR34-YL-365
9.09Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
8.82Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
8.82Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
8.70Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
8.70Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
8.70Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
8.70Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
8.70Consensushcar_offOrthosteric Ligandsuccinate_off
8.70Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
8.57Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
8.33Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
8.33Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
8.33Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
8.33Single6Z4SSR486926Z4S-NTS1-SR48692
8.33Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
8.33Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
8.33Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
8.33Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
8.33Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
8.11Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
8.00Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
8.00Single4BV0Neurotensin4BV0-NTS1-Neurotensin
8.00Single5V57TC1145V57-SMO-TC114
8.00Single6OS1TRV0266OS1-AT1-TRV026
8.00Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
8.00Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
8.00Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
8.00Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
7.69Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
7.69Single6OS2TRV0266OS2-AT1-TRV026
7.69Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
7.69Single6YVRNTS8-136YVR-NTS1-NTS8-13
7.69Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
7.69Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
7.69Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
7.41Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
7.41Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
7.41Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
7.41Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.41Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14Single6KNMJN241-96KNM-Apelin-JN241-9
7.14Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
7.14Consensusclass-c_offOther Ligandgabab_off mglu_off
7.14Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.90Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
6.90Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
6.67Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
6.67Single7SHEPI; PE7SHE-GPR158-PI; PE
6.67Single7SK5CXCL127SK5-ACKR3-CXCL12
6.45Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
6.45Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
5.88Single7SK3CXCL127SK3-ACKR3-CXCL12
5.88Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
5.88Consensusccr8_offOrthosteric Ligand8TLM-CCR8-Anti-murine CCR8 antibody
5.71Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
5.56Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
5.56Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
5.26Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
5.26Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
5.26Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
5.00Single3OE8IT1t3OE8-CXCR4-IT1t
5.00Single4XNWMRS25004XNW-P2Y1-MRS2500
5.00Single6LI0GTPL98046LI0-GPR52-GTPL9804
5.00Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
5.00Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
5.00Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
4.76Single4O9RCyclopamine4O9R-SMO-Cyclopamine
4.76Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
4.76Single7UL2SR486927UL2-NTS1-SR48692-Na
4.76Single7XKFBetahydroxyandrosterone7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
4.76Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
4.76Single8J6QCompound 9n8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
4.76Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
4.76Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
4.76Consensusgo_proteinOrthosteric Ligandgo_chemokine
4.76Consensushca2_on_alloOther Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
4.76Consensusnts1_off_alloOrthosteric Ligand7UL2-NTS1-SR48692-Na
4.76Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.55Single4BWBNeurotensin4BWB-NTS1-Neurotensin
4.55Single4K5YCP-3763954K5Y-CRF1-CP-376395
4.55Single4QINSAG1.54QIN-SMO-SAG1.5
4.55Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
4.55Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
4.55Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
4.55Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
4.55Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
4.55Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
4.55Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
4.55Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2
4.55Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
4.55Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
4.55Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
4.55Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
4.44Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
4.35Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
4.35Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.35Single6ZINSR486926ZIN-NTS1-SR48692
4.35Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
4.35Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
4.35Single7XJJGalanin7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
4.35Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
4.35Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
4.35Single8K2WAMG4878K2W-CXCR3-AMG487
4.35Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
4.35Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
4.35Consensusgi_class-fOrthosteric Ligandgi_frizzled
4.35Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.35Consensusgo_galaninOrthosteric Ligand7XJJ-GAL1-Galanin-Go/&β;1/&γ;2
4.35Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
4.17Single4Z9GCP-3763954Z9G-CRF1-CP-376395
4.17Single5T04Neurotensin5T04-NTS1-Neurotensin
4.17Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
4.17Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
4.17Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
4.17Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
4.17Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
4.17Single8GTIBMK-C2058GTI-CRF1-BMK-C205
4.17Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
4.17Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/&β;1/&γ;2
4.17Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
4.00Single8GTGBMK-I1528GTG-CRF1-BMK-I152
3.85Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
3.85Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
3.70Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
3.70Single7SHEPI; PE7SHE-GPR158-PI; PE
3.70Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.70Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.70Single8GTMBMK-C2038GTM-CRF1-BMK-C203
3.70Consensuschemokine_offOrthosteric Ligandcxcr_off
3.70Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
3.70Consensuscxcr_offOrthosteric Ligandcxcr4_off
3.57Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
3.33Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
3.33Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
3.23Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.70Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
2.63Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
2.63Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
2.63Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
2.56Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.50Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.50Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.44Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.44Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.33Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.22Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
2.17Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.08Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

PDB Summary
PDB 7EXD
Class A
SubFamily Amine
Type 5-Hydroxytryptamine
SubType 5-HT1F
Species Homo sapiens
Ligand Lasmiditan
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.4
Date 2021-08-04
D.O.I. 10.1038/s41422-021-00527-4
Net Summary
Imin 2.69
Number of Linked Nodes 835
Number of Links 1073
Number of Hubs 202
Number of Links mediated by Hubs 719
Number of Communities 20
Number of Nodes involved in Communities 289
Number of Links involved in Communities 461
Path Summary
Number Of Nodes in MetaPath 99
Number Of Links MetaPath 98
Number of Shortest Paths 3726134
Length Of Smallest Path 3
Average Path Length 44.2048
Length of Longest Path 78
Minimum Path Strength 1.295
Average Path Strength 6.02016
Maximum Path Strength 23.885
Minimum Path Correlation 0.7
Average Path Correlation 0.990035
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.72414
Average % Of Corr. Nodes 30.1419
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 56.6398
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
Code05X
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
Code05X
NameLasmiditan
Synonyms
  • Lasmiditan succinate
  • Lasmiditan
Identifier2,4,6-tris(fluoranyl)-~{N}-[6-(1-methylpiperidin-4-yl)carbonylpyridin-2-yl]benzamide
FormulaC19 H18 F3 N3 O2
Molecular Weight377.36
SMILESCN1CCC(CC1)C(=O)c2cccc(n2)NC(=O)c3c(cc(cc3F)F)F
PubChem11610526
Formal Charge0
Total Atoms45
Total Chiral Atoms0
Total Bonds47
Total Aromatic Bonds12

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7EXD_Chain_A
TLSAEDKAA VERSKMIDR NLREDGEKA AREVKLLLL GAGESGKNT 
IVKQMKITG IVETHFTFK DLHFKMFDV GAQRSERKK WIHCFEGVT 
AIIFCVALS DYDLVLNRM HASMKLFDS ICNNKWFTD TSIILFLNK 
KDLFEEKIK KSPLTICYP EYAGSNTYE EAAAYIQCQ FEDLNKRKD 
TKEIYTHFT CSTDTKNVQ FVFDAVTDV IIKNNLKDC GLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7EXD_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP FREK


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP30939
Sequence
>7EXD_Chain_R
RMPSKILVS LTLSGLALM TTTINSLVI AAIIVTRKL HHPANYLIC 
SLAVTDFLV AVLVMPFSI VYIVRESWI MGQVVCDIW LSVDITCCT 
CSILHLSAI ALDRYRAIT DAVEYARKR TPKHAGIMI TIVWIISVF 
ISMPPLFWR HQGTSRDDE CIIKHDHIV STIYSTFGA FYIPLALIL 
ILYYKIYRA AKTLYHGTR ERKAATTLG LILGAFVIC WLPFFVKEL 
VVNVCDKCK ISEEMSNFL AWLGYLNSL INPLIYTIF NEDFKKAFQ 
KL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7EXD_Chain_B
LDQLRQEAE QLKNQIRDA RKACADATL SQITNNIDP VGRIQMRTR 
RTLRGHLAK IYAMHWGTD SRLLVSASQ DGKLIIWDS YTTNKVHAI 
PLRSSWVMT CAYAPSGNY VACGGLDNI CSIYNLKTR EGNVRVSRE 
LAGHTGYLS CCRFLDDNQ IVTSSGDTT CALWDIETG QQTTTFTGH 
TGDVMSLSL APDTRLFVS GACDASAKL WDVREGMCR QTFTGHESD 
INAICFFPN GNAFATGSD DATCRLFDL RADQELMTY SHDNIICGI 
TSVSFSKSG RLLLAGYDD FNCNVWDAL KADRAGVLA GHDNRVSCL 
GVTDDGMAV ATGSWDSFL KIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  



This network is also present in following consensuses:
IdComponents
5ht1f_on7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
gi_5ht7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI




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