psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D103	14.42	Yes	No	1	0	8
2	L:L:?1	R:R:I104	10.11	Yes	No	0	0	7
3	L:L:?1	R:R:C107	10.12	Yes	No	1	0	7
4	L:L:?1	R:R:I174	12.13	Yes	No	0	0	5
5	L:L:?1	R:R:H176	7.29	Yes	Yes	1	0	5
6	L:L:?1	R:R:T182	6.26	Yes	No	1	0	7
7	L:L:?1	R:R:S185	3.19	Yes	No	0	0	7
8	L:L:?1	R:R:W306	6.45	Yes	Yes	1	0	9
9	L:L:?1	R:R:F309	12.08	Yes	Yes	1	0	7
10	L:L:?1	R:R:F310	10.35	Yes	No	1	0	6
11	L:L:?1	R:R:E313	11.26	Yes	Yes	1	0	6
12	L:L:?1	R:R:N317	9.73	Yes	Yes	1	0	6
13	L:L:?1	R:R:Y337	6.64	Yes	Yes	1	0	7
14	R:R:M20	R:R:R19	4.96	No	No	0	1	4
15	R:R:L25	R:R:V26	4.47	No	No	0	4	4
16	R:R:S27	R:R:V85	4.85	No	Yes	0	5	5
17	R:R:I81	R:R:L30	7.14	No	Yes	1	7	6
18	R:R:L30	R:R:W334	10.25	Yes	Yes	1	6	7
19	R:R:G32	R:R:L35	3.42	No	No	0	4	4
20	R:R:L33	R:R:W334	5.69	No	Yes	0	6	7
21	R:R:A34	R:R:M77	3.22	No	Yes	0	6	8
22	R:R:L341	R:R:M36	5.65	No	No	0	6	4
23	R:R:L341	R:R:T37	10.32	No	No	0	6	8
24	R:R:A73	R:R:T38	3.36	No	No	0	7	6
25	R:R:I40	R:R:P344	3.39	No	No	0	8	9
26	R:R:D69	R:R:N41	6.73	Yes	No	0	9	9
27	R:R:F70	R:R:N41	3.62	No	No	0	8	9
28	R:R:N41	R:R:P344	6.52	No	No	0	9	9
29	R:R:C63	R:R:I45	3.27	No	No	0	6	7
30	R:R:A66	R:R:I45	3.25	No	No	0	9	7
31	R:R:A46	R:R:L361	3.15	No	No	0	4	6
32	R:R:C63	R:R:I48	6.55	No	No	0	6	8
33	R:R:F354	R:R:I48	5.02	Yes	No	0	8	8
34	R:R:L54	R:R:T51	7.37	Yes	No	0	8	6
35	R:R:A357	R:R:T51	5.03	No	No	0	8	6
36	R:R:L54	R:R:N59	4.12	Yes	Yes	3	8	9
37	R:R:D353	R:R:L54	5.43	No	Yes	0	6	8
38	R:R:F354	R:R:L54	13.4	Yes	Yes	3	8	8
39	R:R:H55	R:R:Y60	8.71	No	No	0	8	6
40	R:R:H56	R:R:N59	8.93	No	Yes	0	7	9
41	R:R:P137	R:R:P57	5.84	No	No	0	4	6
42	R:R:A58	R:R:R135	5.53	No	Yes	0	8	7
43	R:R:F354	R:R:N59	8.46	Yes	Yes	3	8	9
44	R:R:P137	R:R:Y60	4.17	No	No	0	4	6
45	R:R:A140	R:R:Y60	4	No	No	0	6	6
46	R:R:I117	R:R:L61	4.28	No	No	0	9	8
47	R:R:H113	R:R:S64	11.16	Yes	No	4	8	9
48	R:R:I144	R:R:S64	7.74	No	No	4	8	9
49	R:R:D69	R:R:L65	4.07	Yes	Yes	1	9	9
50	R:R:L114	R:R:L65	5.54	Yes	Yes	1	9	9
51	R:R:L65	R:R:N343	8.24	Yes	Yes	1	9	9
52	R:R:C109	R:R:T68	3.38	Yes	No	4	7	8
53	R:R:H113	R:R:T68	5.48	Yes	No	4	8	8
54	R:R:D69	R:R:S340	10.31	Yes	No	0	9	9
55	R:R:D69	R:R:N343	6.73	Yes	Yes	1	9	9
56	R:R:V72	R:R:V76	3.21	No	Yes	0	7	7
57	R:R:C106	R:R:V72	3.42	No	No	0	6	7
58	R:R:S340	R:R:V72	4.85	No	No	0	9	7
59	R:R:L75	R:R:V74	4.47	No	No	0	5	5
60	R:R:L75	R:R:V102	4.47	No	No	0	5	5
61	R:R:V76	R:R:W99	4.9	Yes	Yes	0	7	6
62	R:R:V102	R:R:V76	3.21	No	Yes	0	5	7
63	R:R:D103	R:R:V76	4.38	No	Yes	0	8	7
64	R:R:M77	R:R:W334	9.31	Yes	Yes	1	8	7
65	R:R:M77	R:R:Y337	3.59	Yes	Yes	1	8	7
66	R:R:F79	R:R:W99	11.02	No	Yes	0	6	6
67	R:R:S80	R:R:W334	3.71	No	Yes	0	6	7
68	R:R:I81	R:R:W334	7.05	No	Yes	1	7	7
69	R:R:W89	R:R:Y83	7.72	Yes	Yes	2	8	5
70	R:R:E171	R:R:Y83	3.37	No	Yes	0	4	5
71	R:R:E326	R:R:Y83	4.49	No	Yes	2	2	5
72	R:R:N330	R:R:Y83	5.81	No	Yes	2	6	5
73	R:R:I84	R:R:N330	4.25	No	No	0	5	6
74	R:R:D170	R:R:S88	8.83	No	No	0	3	3
75	R:R:M91	R:R:W89	3.49	No	Yes	0	6	8
76	R:R:C96	R:R:W89	3.92	No	Yes	2	9	8
77	R:R:W89	R:R:W99	11.25	Yes	Yes	2	8	6
78	R:R:C172	R:R:W89	18.28	No	Yes	2	9	8
79	R:R:Q93	R:R:W161	6.57	No	No	0	3	6
80	R:R:Q93	R:R:S167	5.78	No	No	0	3	3
81	R:R:C96	R:R:W161	6.53	No	No	0	9	6
82	R:R:C172	R:R:C96	7.28	No	No	2	9	9
83	R:R:I98	R:R:S101	4.64	No	No	0	4	6
84	R:R:C172	R:R:W99	5.22	No	Yes	2	9	6
85	R:R:I174	R:R:L100	7.14	No	No	0	5	6
86	R:R:S101	R:R:V102	3.23	No	No	0	6	5
87	R:R:D103	R:R:Y337	10.34	No	Yes	1	8	7
88	R:R:I104	R:R:S155	7.74	No	No	0	7	8
89	R:R:I104	R:R:P158	6.77	No	No	0	7	7
90	R:R:S151	R:R:T105	4.8	Yes	No	0	8	6
91	R:R:C107	R:R:W306	5.22	No	Yes	1	7	9
92	R:R:S151	R:R:T108	3.2	Yes	No	0	8	8
93	R:R:I154	R:R:T108	6.08	No	No	0	7	8
94	R:R:C109	R:R:H113	7.37	Yes	Yes	4	7	8
95	R:R:C109	R:R:W148	11.75	Yes	No	0	7	9
96	R:R:C109	R:R:S151	3.44	Yes	Yes	0	7	8
97	R:R:F190	R:R:I111	3.77	Yes	No	1	8	8
98	R:R:I111	R:R:P193	3.39	No	No	0	8	9
99	R:R:F302	R:R:I111	7.54	Yes	No	1	9	8
100	R:R:L112	R:R:V147	4.47	No	No	0	7	6
101	R:R:H113	R:R:I144	3.98	Yes	No	4	8	8
102	R:R:H113	R:R:V147	13.84	Yes	No	0	8	6
103	R:R:F302	R:R:L114	4.87	Yes	Yes	1	9	9
104	R:R:L114	R:R:N343	10.98	Yes	Yes	1	9	9
105	R:R:L114	R:R:Y347	7.03	Yes	Yes	1	9	9
106	R:R:P193	R:R:S115	5.34	No	No	0	9	7
107	R:R:A116	R:R:M143	3.22	No	No	0	7	7
108	R:R:I117	R:R:R121	5.01	No	No	0	9	9
109	R:R:A118	R:R:I197	3.25	No	No	0	9	8
110	R:R:A118	R:R:L200	3.15	No	Yes	0	9	6
111	R:R:D120	R:R:Y131	8.05	No	Yes	6	9	8
112	R:R:D120	R:R:R135	13.1	No	Yes	6	9	7
113	R:R:R121	R:R:Y201	5.14	No	Yes	0	9	9
114	R:R:R121	R:R:Y347	6.17	No	Yes	0	9	9
115	R:R:T126	R:R:Y122	14.98	No	Yes	0	6	8
116	R:R:L200	R:R:Y122	7.03	Yes	Yes	0	6	8
117	R:R:K203	R:R:Y122	8.36	No	Yes	0	5	8
118	R:R:R123	R:R:Y131	17.49	No	Yes	0	5	8
119	R:R:A124	R:R:R135	4.15	No	Yes	0	8	7
120	R:R:D127	R:R:T126	10.12	No	No	0	5	6
121	R:R:D127	R:R:E130	5.2	No	No	0	5	5
122	R:R:E130	R:R:V129	8.56	No	No	0	5	7
123	R:R:R135	R:R:Y131	10.29	Yes	Yes	6	7	8
124	R:R:H139	R:R:Y131	9.8	No	Yes	0	7	8
125	R:R:P137	R:R:T136	5.25	No	No	0	4	8
126	R:R:H139	R:R:M143	3.94	No	No	0	7	7
127	R:R:F153	R:R:I149	7.54	No	No	0	4	4
128	R:R:A189	R:R:I154	3.25	No	No	0	7	7
129	R:R:M156	R:R:P157	3.35	No	No	0	5	8
130	R:R:P157	R:R:P158	5.84	No	No	0	8	7
131	R:R:P157	R:R:S181	3.56	No	No	0	8	7
132	R:R:P158	R:R:S185	5.34	No	No	0	7	7
133	R:R:F160	R:R:H176	9.05	No	Yes	0	5	5
134	R:R:D169	R:R:T166	4.34	No	No	0	2	4
135	R:R:D169	R:R:E171	10.39	No	No	0	2	4
136	R:R:E171	R:R:I173	9.56	No	No	0	4	4
137	R:R:E326	R:R:I173	5.47	No	No	0	2	4
138	R:R:D177	R:R:K175	11.06	No	No	0	5	5
139	R:R:H176	R:R:H178	9.55	Yes	No	1	5	4
140	R:R:H176	R:R:S181	5.58	Yes	No	1	5	7
141	R:R:H176	R:R:T182	4.11	Yes	No	1	5	7
142	R:R:H178	R:R:V180	4.15	No	No	0	4	4
143	R:R:H178	R:R:S181	4.18	No	No	1	4	7
144	R:R:F187	R:R:I183	7.54	No	No	0	4	6
145	R:R:L314	R:R:T186	5.9	No	No	0	6	7
146	R:R:F187	R:R:Y191	6.19	No	Yes	0	4	6
147	R:R:G188	R:R:I192	3.53	No	No	0	5	7
148	R:R:F190	R:R:Y191	5.16	Yes	Yes	0	8	6
149	R:R:F190	R:R:L194	13.4	Yes	No	0	8	5
150	R:R:F190	R:R:F302	7.5	Yes	Yes	1	8	9
151	R:R:F190	R:R:L307	3.65	Yes	No	0	8	6
152	R:R:F190	R:R:F310	15	Yes	No	1	8	6
153	R:R:L314	R:R:Y191	3.52	No	Yes	0	6	6
154	R:R:I192	R:R:P193	3.39	No	No	0	7	9
155	R:R:L196	R:R:L200	5.54	No	Yes	0	6	6
156	R:R:I197	R:R:Y201	4.84	No	Yes	0	8	9
157	R:R:L198	R:R:L299	5.54	No	No	0	6	8
158	R:R:L295	R:R:Y201	7.03	No	Yes	0	8	9
159	R:R:I298	R:R:Y201	8.46	No	Yes	0	8	9
160	R:R:R206	R:R:Y202	6.17	No	No	0	4	3
161	R:R:K209	R:R:Y205	4.78	Yes	No	5	6	6
162	R:R:E288	R:R:Y205	4.49	Yes	No	5	8	6
163	R:R:L295	R:R:Y205	3.52	No	No	0	8	6
164	R:R:K209	R:R:Y212	5.97	Yes	No	5	6	5
165	R:R:H213	R:R:K209	9.17	No	Yes	0	6	6
166	R:R:E288	R:R:K209	8.1	Yes	Yes	5	8	6
167	R:R:H213	R:R:T210	6.85	No	No	0	6	5
168	R:R:G285	R:R:Y212	4.35	No	No	0	3	5
169	R:R:E288	R:R:Y212	10.1	Yes	No	5	8	5
170	R:R:K290	R:R:T294	4.5	No	No	0	8	8
171	R:R:F350	R:R:T294	6.49	No	No	0	7	8
172	R:R:I298	R:R:I346	4.42	No	Yes	1	8	8
173	R:R:I298	R:R:Y347	13.3	No	Yes	1	8	9
174	R:R:G300	R:R:V303	3.68	No	No	0	5	6
175	R:R:A301	R:R:I346	3.25	No	Yes	0	6	8
176	R:R:F302	R:R:W306	7.02	Yes	Yes	1	9	9
177	R:R:F302	R:R:N339	4.83	Yes	Yes	1	9	9
178	R:R:C305	R:R:N339	6.3	No	Yes	0	8	9
179	R:R:F310	R:R:W306	6.01	No	Yes	1	6	9
180	R:R:G336	R:R:W306	8.44	No	Yes	0	7	9
181	R:R:N339	R:R:W306	6.78	Yes	Yes	1	9	9
182	R:R:L335	R:R:P308	4.93	No	No	0	7	9
183	R:R:F309	R:R:K312	6.2	Yes	Yes	1	7	5
184	R:R:E313	R:R:F309	5.83	Yes	Yes	1	6	7
185	R:R:F309	R:R:L332	3.65	Yes	No	1	7	6
186	R:R:A333	R:R:F309	4.16	No	Yes	0	5	7
187	R:R:E313	R:R:K312	4.05	Yes	Yes	1	6	5
188	R:R:K312	R:R:V316	4.55	Yes	Yes	0	5	4
189	R:R:I324	R:R:K312	4.36	No	Yes	0	4	5
190	R:R:K312	R:R:S329	7.65	Yes	No	0	5	5
191	R:R:K312	R:R:L332	5.64	Yes	No	1	5	6
192	R:R:E313	R:R:N317	7.89	Yes	Yes	1	6	6
193	R:R:L314	R:R:V318	4.47	No	No	0	6	5
194	R:R:N317	R:R:V316	7.39	Yes	Yes	0	6	4
195	R:R:K323	R:R:V316	13.66	No	Yes	0	1	4
196	R:R:C322	R:R:D320	4.67	No	No	0	7	1
197	R:R:I324	R:R:K323	4.36	No	No	0	4	1
198	R:R:E326	R:R:N330	9.2	No	No	2	2	6
199	R:R:W334	R:R:Y337	3.86	Yes	Yes	1	7	7
200	R:R:L338	R:R:L341	4.15	No	No	0	5	6
201	R:R:I342	R:R:L338	8.56	No	No	0	6	5
202	R:R:N339	R:R:N343	10.9	Yes	Yes	1	9	9
203	R:R:I342	R:R:I346	5.89	No	Yes	0	6	8
204	R:R:N343	R:R:Y347	5.81	Yes	Yes	1	9	9
205	R:R:I346	R:R:Y347	6.04	Yes	Yes	1	8	9
206	R:R:F354	R:R:T348	16.86	Yes	No	3	8	8
207	R:R:F358	R:R:T348	3.89	Yes	No	3	8	8
208	R:R:F350	R:R:I349	7.54	No	No	0	7	5
209	R:R:D353	R:R:N351	6.73	No	No	0	6	9
210	R:R:F354	R:R:N351	6.04	Yes	No	0	8	9
211	R:R:F354	R:R:F358	7.5	Yes	Yes	3	8	8
212	L:L:?1	R:R:T108	3.13	Yes	No	0	0	8
213	R:R:I90	R:R:S88	3.1	No	No	0	3	3
214	R:R:I48	R:R:V44	3.07	No	No	0	8	9
215	R:R:I45	R:R:V67	3.07	No	No	0	7	6
216	R:R:I49	R:R:V50	3.07	No	No	0	3	6
217	R:R:I98	R:R:V95	3.07	No	No	0	4	5
218	R:R:H56	R:R:P57	3.05	No	No	0	7	6
219	R:R:I40	R:R:T39	3.04	No	No	0	8	4
220	R:R:M91	R:R:V82	3.04	No	No	0	6	5
221	R:R:I142	R:R:T145	3.04	No	No	0	3	4
222	R:R:I146	R:R:T145	3.04	No	No	0	3	4
223	R:R:L35	R:R:S31	3	No	No	0	4	4
224	R:R:L65	R:R:S110	3	Yes	No	0	9	9
225	R:R:L43	R:R:V44	2.98	No	No	0	7	9
226	R:R:L71	R:R:V67	2.98	No	No	0	7	6
227	R:R:L299	R:R:V303	2.98	No	No	0	8	6
228	R:R:L307	R:R:V303	2.98	No	No	0	6	6
229	R:R:A58	R:R:H56	2.93	No	No	0	8	7
230	R:R:I90	R:R:M91	2.92	No	No	0	3	6
231	R:R:I324	R:R:M328	2.92	No	No	0	4	5
232	R:R:I24	R:R:L28	2.85	No	No	0	5	4
233	R:R:I40	R:R:L43	2.85	No	No	0	8	7
234	R:R:I150	R:R:L112	2.85	No	No	0	4	7
235	R:R:I346	R:R:L297	2.85	Yes	No	0	8	6
236	R:R:I62	R:R:N59	2.83	No	Yes	0	8	9
237	R:R:G165	R:R:W161	2.81	No	No	0	4	6
238	R:R:D97	R:R:I98	2.8	No	No	0	6	4
239	R:R:K175	R:R:N317	2.8	No	Yes	0	5	6
240	R:R:A47	R:R:F358	2.77	No	Yes	0	8	8
241	R:R:D353	R:R:K53	2.77	No	No	0	6	6
242	R:R:L119	R:R:L200	2.77	No	Yes	0	6	6
243	R:R:R86	R:R:V85	2.62	No	Yes	0	4	5
244	R:R:F70	R:R:T38	2.59	No	No	0	8	6
245	R:R:R206	R:R:T210	2.59	No	No	0	4	5
246	R:R:V311	R:R:Y191	2.52	No	Yes	0	5	6
247	R:R:K134	R:R:R133	2.48	No	No	0	5	4
248	R:R:H163	R:R:Q164	2.47	No	No	0	4	1
249	R:R:F350	R:R:L297	2.44	No	No	0	7	6
250	R:R:F331	R:R:L332	2.44	No	No	0	4	6
251	R:R:I204	R:R:Y122	2.42	No	Yes	0	9	8
252	R:R:A140	R:R:G141	1.95	No	No	0	6	4
253	R:R:G296	R:R:L295	1.71	No	No	0	6	8
254	R:R:C319	R:R:V318	1.71	No	No	0	4	5
255	R:R:M20	R:R:P21	1.68	No	No	0	1	1
256	R:R:M77	R:R:P78	1.68	Yes	No	0	8	9
257	R:R:A207	R:R:T210	1.68	No	No	0	6	5
258	R:R:L307	R:R:P308	1.64	No	No	0	6	9
259	R:R:A207	R:R:I125	1.62	No	No	0	6	9
260	R:R:S151	R:R:V152	1.62	Yes	No	0	8	5
261	R:R:S42	R:R:T39	1.6	No	No	0	5	4
262	R:R:V94	R:R:V95	1.6	No	No	0	1	5
263	R:R:V311	R:R:V315	1.6	No	No	0	5	5
264	R:R:V315	R:R:V316	1.6	No	Yes	0	5	4
265	R:R:A47	R:R:L361	1.58	No	No	0	8	6
266	R:R:I81	R:R:V85	1.54	No	Yes	0	7	5
267	R:R:I84	R:R:V85	1.54	No	Yes	0	5	5
268	R:R:I179	R:R:V180	1.54	No	No	0	4	4
269	R:R:I179	R:R:V318	1.54	No	No	0	4	5
270	R:R:M328	R:R:S325	1.53	No	No	0	5	5
271	R:R:K360	R:R:V50	1.52	No	No	0	5	6
272	R:R:A292	R:R:E288	1.51	No	Yes	0	7	8
273	R:R:K138	R:R:T136	1.5	No	No	0	4	8
274	R:R:L30	R:R:V26	1.49	Yes	No	0	6	4
275	R:R:L30	R:R:T29	1.47	Yes	No	0	6	4
276	R:R:I146	R:R:I149	1.47	No	No	0	3	4
277	R:R:I146	R:R:I150	1.47	No	No	0	3	4
278	R:R:I24	R:R:M20	1.46	No	No	0	5	1
279	R:R:I199	R:R:K203	1.45	No	No	0	5	5
280	R:R:E327	R:R:S325	1.44	No	No	0	3	5
281	R:R:G92	R:R:W89	1.41	No	Yes	0	7	8
282	R:R:E87	R:R:K23	1.35	No	No	0	4	4
283	R:R:E352	R:R:N351	1.31	No	No	0	6	9
284	R:R:F358	R:R:Q359	1.17	Yes	No	0	8	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.79714	14	1	0
2	R:R:L30	5.0875	4	1	6
3	R:R:L54	7.58	4	3	8
4	R:R:N59	6.085	4	3	9
5	R:R:L65	5.2125	4	1	9
6	R:R:D69	6.96	4	1	9
7	R:R:V76	3.925	4	0	7
8	R:R:M77	4.45	4	1	8
9	R:R:Y83	5.3475	4	2	5
10	R:R:V85	2.6375	4	0	5
11	R:R:W89	7.67833	6	2	8
12	R:R:W99	8.0975	4	2	6
13	R:R:C109	6.485	4	4	7
14	R:R:H113	8.366	5	4	8
15	R:R:L114	7.105	4	1	9
16	R:R:Y122	8.1975	4	0	8
17	R:R:Y131	11.4075	4	6	8
18	R:R:R135	8.2675	4	6	7
19	R:R:S151	3.265	4	0	8
20	R:R:H176	7.116	5	1	5
21	R:R:F190	8.08	6	1	8
22	R:R:Y191	4.3475	4	0	6
23	R:R:L200	4.6225	4	0	6
24	R:R:Y201	6.3675	4	0	9
25	R:R:K209	7.005	4	5	6
26	R:R:E288	6.05	4	5	8
27	R:R:F302	6.352	5	1	9
28	R:R:W306	6.65333	6	1	9
29	R:R:F309	6.384	5	1	7
30	R:R:K312	5.40833	6	1	5
31	R:R:E313	7.2575	4	1	6
32	R:R:V316	6.8	4	0	4
33	R:R:N317	6.9525	4	1	6
34	R:R:W334	6.645	6	1	7
35	R:R:Y337	6.1075	4	1	7
36	R:R:N339	7.2025	4	1	9
37	R:R:N343	8.532	5	1	9
38	R:R:I346	4.49	5	1	8
39	R:R:Y347	7.67	5	1	9
40	R:R:F354	9.54667	6	3	8
41	R:R:F358	3.8325	4	3	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y337	27.7696	6.64	Yes	Yes	1	0	7
2	R:R:W334	R:R:Y337	25.6114	3.86	Yes	Yes	1	7	7
3	R:R:I81	R:R:W334	10.5996	7.05	No	Yes	1	7	7
4	L:L:?1	R:R:W306	100	6.45	Yes	Yes	1	0	9
5	R:R:F302	R:R:W306	41.2994	7.02	Yes	Yes	1	9	9
6	R:R:F302	R:R:L114	63.8679	4.87	Yes	Yes	1	9	9
7	R:R:L114	R:R:Y347	47.6558	7.03	Yes	Yes	1	9	9
8	R:R:I346	R:R:Y347	19.8467	6.04	Yes	Yes	1	8	9
9	R:R:N339	R:R:W306	62.6902	6.78	Yes	Yes	1	9	9
10	R:R:N339	R:R:N343	70.5849	10.9	Yes	Yes	1	9	9
11	R:R:N343	R:R:Y347	77.0709	5.81	Yes	Yes	1	9	9
12	R:R:D69	R:R:N343	81.0267	6.73	Yes	Yes	1	9	9
13	R:R:D69	R:R:N41	87.0055	6.73	Yes	No	0	9	9
14	R:R:N41	R:R:P344	81.3254	6.52	No	No	0	9	9
15	R:R:I40	R:R:P344	79.8772	3.39	No	No	0	8	9
16	R:R:I40	R:R:L43	75.4649	2.85	No	No	0	8	7
17	R:R:L43	R:R:V44	73.9716	2.98	No	No	0	7	9
18	R:R:I48	R:R:V44	72.467	3.07	No	No	0	8	9
19	R:R:F354	R:R:I48	63.1861	5.02	Yes	No	0	8	8
20	R:R:F354	R:R:N59	35.9292	8.46	Yes	Yes	3	8	9
21	R:R:H56	R:R:N59	33.2131	8.93	No	Yes	0	7	9
22	R:R:H56	R:R:P57	15.4119	3.05	No	No	0	7	6
23	R:R:P137	R:R:P57	13.5242	5.84	No	No	0	4	6
24	R:R:A58	R:R:H56	16.832	2.93	No	No	0	8	7
25	R:R:R121	R:R:Y347	53.6234	6.17	No	Yes	0	9	9
26	L:L:?1	R:R:T108	39.6089	3.13	Yes	No	0	0	8
27	R:R:S151	R:R:T108	34.002	3.2	Yes	No	0	8	8
28	R:R:C109	R:R:S151	28.2373	3.44	Yes	Yes	0	7	8
29	R:R:C109	R:R:H113	22.3093	7.37	Yes	Yes	4	7	8
30	R:R:L114	R:R:L65	10.2446	5.54	Yes	Yes	1	9	9
31	L:L:?1	R:R:D103	23.7011	14.42	Yes	No	1	0	8
32	R:R:D103	R:R:V76	29.6292	4.38	No	Yes	0	8	7
33	R:R:V72	R:R:V76	34.8135	3.21	No	Yes	0	7	7
34	R:R:S340	R:R:V72	34.8473	4.85	No	No	0	9	7
35	R:R:V102	R:R:V76	12.8874	3.21	No	Yes	0	5	7
36	R:R:V76	R:R:W99	39.9245	4.9	Yes	Yes	0	7	6
37	R:R:W89	R:R:W99	28.8121	11.25	Yes	Yes	2	8	6
38	R:R:W89	R:R:Y83	12.6676	7.72	Yes	Yes	2	8	5
39	R:R:C96	R:R:W161	12.1098	6.53	No	No	0	9	6
40	L:L:?1	R:R:F310	14.4652	10.35	Yes	No	1	0	6
41	R:R:F190	R:R:F310	14.6512	15	Yes	No	1	8	6
42	R:R:F302	R:R:I111	10.5601	7.54	Yes	No	1	9	8
43	R:R:I111	R:R:P193	11.6702	3.39	No	No	0	8	9
44	R:R:H113	R:R:V147	16.4037	13.84	Yes	No	0	8	6
45	R:R:L112	R:R:V147	14.392	4.47	No	No	0	7	6
46	R:R:A58	R:R:R135	14.9498	5.53	No	Yes	0	8	7
47	R:R:R121	R:R:Y201	49.2843	5.14	No	Yes	0	9	9
48	R:R:I197	R:R:Y201	45.4863	4.84	No	Yes	0	8	9
49	R:R:A118	R:R:I197	42.0546	3.25	No	No	0	9	8
50	R:R:I298	R:R:Y347	50.4508	13.3	No	Yes	1	8	9
51	R:R:I298	R:R:Y201	50.9918	8.46	No	Yes	0	8	9
52	R:R:A118	R:R:L200	38.6115	3.15	No	Yes	0	9	6
53	R:R:L200	R:R:Y122	28.2148	7.03	Yes	Yes	0	6	8
54	R:R:T126	R:R:Y122	14.1947	14.98	No	Yes	0	6	8
55	R:R:D127	R:R:T126	10.6616	10.12	No	No	0	5	6
56	R:R:I150	R:R:L112	12.369	2.85	No	No	0	4	7
57	R:R:I146	R:R:I150	10.3347	1.47	No	No	0	3	4
58	L:L:?1	R:R:H176	15.5134	7.29	Yes	Yes	1	0	5
59	L:L:?1	R:R:N317	10.9039	9.73	Yes	Yes	1	0	6
60	R:R:F190	R:R:Y191	19.4185	5.16	Yes	Yes	0	8	6
61	R:R:L314	R:R:Y191	10.1488	3.52	No	Yes	0	6	6
62	R:R:F190	R:R:L307	15.395	3.65	Yes	No	0	8	6
63	R:R:L295	R:R:Y201	54.3277	7.03	No	Yes	0	8	9
64	R:R:L295	R:R:Y205	47.7403	3.52	No	No	0	8	6
65	R:R:K209	R:R:Y205	30.79	4.78	Yes	No	5	6	6
66	R:R:H213	R:R:K209	20.9118	9.17	No	Yes	0	6	6
67	R:R:H213	R:R:T210	17.4124	6.85	No	No	0	6	5
68	R:R:E288	R:R:Y205	13.5242	4.49	Yes	No	5	8	6
69	L:L:?1	R:R:F309	19.0578	12.08	Yes	Yes	1	0	7
70	R:R:F309	R:R:K312	11.2927	6.2	Yes	Yes	1	7	5
71	L:L:?1	R:R:E313	13.1128	11.26	Yes	Yes	1	0	6
72	R:R:E313	R:R:K312	11.3659	4.05	Yes	Yes	1	6	5
73	R:R:I324	R:R:K312	15.7895	4.36	No	Yes	0	4	5
74	R:R:I324	R:R:M328	12.0647	2.92	No	No	0	4	5
75	R:R:D69	R:R:S340	35.3432	10.31	Yes	No	0	9	9
76	R:R:F190	R:R:F302	26.868	7.5	Yes	Yes	1	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D103	14.42	1	Yes	No	0	8	0	1
L:L:?1	R:R:I104	10.11	1	Yes	No	0	7	0	1
L:L:?1	R:R:C107	10.12	1	Yes	No	0	7	0	1
L:L:?1	R:R:I174	12.13	1	Yes	No	0	5	0	1
L:L:?1	R:R:H176	7.29	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:T182	6.26	1	Yes	No	0	7	0	1
L:L:?1	R:R:S185	3.19	1	Yes	No	0	7	0	1
L:L:?1	R:R:W306	6.45	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:F309	12.08	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F310	10.35	1	Yes	No	0	6	0	1
L:L:?1	R:R:E313	11.26	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:N317	9.73	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:Y337	6.64	1	Yes	Yes	0	7	0	1
R:R:D103	R:R:V76	4.38	1	No	Yes	8	7	1	2
R:R:M77	R:R:W334	9.31	1	Yes	Yes	8	7	2	2
R:R:M77	R:R:Y337	3.59	1	Yes	Yes	8	7	2	1
R:R:I174	R:R:L100	7.14	0	No	No	5	6	1	2
R:R:D103	R:R:Y337	10.34	1	No	Yes	8	7	1	1
R:R:I104	R:R:S155	7.74	0	No	No	7	8	1	2
R:R:I104	R:R:P158	6.77	0	No	No	7	7	1	2
R:R:C107	R:R:W306	5.22	1	No	Yes	7	9	1	1
R:R:S151	R:R:T108	3.2	0	Yes	No	8	8	2	1
R:R:I154	R:R:T108	6.08	0	No	No	7	8	2	1
R:R:P158	R:R:S185	5.34	0	No	No	7	7	2	1
R:R:F160	R:R:H176	9.05	0	No	Yes	5	5	2	1
R:R:H176	R:R:H178	9.55	1	Yes	No	5	4	1	2
R:R:H176	R:R:S181	5.58	1	Yes	No	5	7	1	2
R:R:H176	R:R:T182	4.11	1	Yes	No	5	7	1	1
R:R:H178	R:R:S181	4.18	1	No	No	4	7	2	2
R:R:F190	R:R:F302	7.5	1	Yes	Yes	8	9	2	2
R:R:F190	R:R:F310	15	1	Yes	No	8	6	2	1
R:R:F302	R:R:W306	7.02	1	Yes	Yes	9	9	2	1
R:R:F302	R:R:N339	4.83	1	Yes	Yes	9	9	2	2
R:R:F310	R:R:W306	6.01	1	No	Yes	6	9	1	1
R:R:G336	R:R:W306	8.44	0	No	Yes	7	9	2	1
R:R:N339	R:R:W306	6.78	1	Yes	Yes	9	9	2	1
R:R:F309	R:R:K312	6.2	1	Yes	Yes	7	5	1	2
R:R:E313	R:R:F309	5.83	1	Yes	Yes	6	7	1	1
R:R:F309	R:R:L332	3.65	1	Yes	No	7	6	1	2
R:R:A333	R:R:F309	4.16	0	No	Yes	5	7	2	1
R:R:E313	R:R:K312	4.05	1	Yes	Yes	6	5	1	2
R:R:K312	R:R:V316	4.55	1	Yes	Yes	5	4	2	2
R:R:K312	R:R:L332	5.64	1	Yes	No	5	6	2	2
R:R:E313	R:R:N317	7.89	1	Yes	Yes	6	6	1	1
R:R:N317	R:R:V316	7.39	1	Yes	Yes	6	4	1	2
R:R:W334	R:R:Y337	3.86	1	Yes	Yes	7	7	2	1
L:L:?1	R:R:T108	3.13	1	Yes	No	0	8	0	1
R:R:K175	R:R:N317	2.8	0	No	Yes	5	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7EXD_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.15
Number of Linked Nodes	252
Number of Links	284
Number of Hubs	41
Number of Links mediated by Hubs	150
Number of Communities	6
Number of Nodes involved in Communities	54
Number of Links involved in Communities	77

Path Summary
Number Of Nodes in MetaPath	77
Number Of Links MetaPath	76
Number of Shortest Paths	48724
Length Of Smallest Path	3
Average Path Length	12.9039
Length of Longest Path	30
Minimum Path Strength	1.47
Average Path Strength	6.02399
Maximum Path Strength	15.13
Minimum Path Correlation	0.7
Average Path Correlation	0.921138
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	45.9342
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.7584
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • serotonin binding • amine binding • heterocyclic compound binding • G protein-coupled amine receptor activity • G protein-coupled serotonin receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • Gi/o-coupled serotonin receptor activity • neurotransmitter receptor activity • serotonin receptor activity • electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Gene Ontology	Biological Process	• electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • cell-cell signaling • chemical synaptic transmission • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cellular anatomical structure • periplasmic space • synapse • cell junction • cell periphery • plasma membrane • membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	05X
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	05X
Name	Lasmiditan
Synonyms	Lasmiditan Lasmiditan succinate
Identifier
Formula	C19 H18 F3 N3 O2
Molecular Weight	377.36
SMILES
PubChem	11610526
Formal Charge	0
Total Atoms	45
Total Chiral Atoms	0
Total Bonds	47
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30939
Sequence	>7EXD_nogp_Chain_R R M P S K I L V S L T L S G L A L M T T T I N S L V I A A I I V T R K L H H P A N Y L I C S L A V T D F L V A V L V M P F S I V Y I V R E S W I M G Q V V C D I W L S V D I T C C T C S I L H L S A I A L D R Y R A I T D A V E Y A R K R T P K H A G I M I T I V W I I S V F I S M P P L F W R H Q G T S R D D E C I I K H D H I V S T I Y S T F G A F Y I P L A L I L I L Y Y K I Y R A A K T L Y H G T R E R K A A T T L G L I L G A F V I C W L P F F V K E L V V N V C D K C K I S E E M S N F L A W L G Y L N S L I N P L I Y T I F N E D F K K A F Q K L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7EXD	A	Amine	5-Hydroxytryptamine	5-HT_1F	Homo sapiens	Lasmiditan	-	Gi1/β1/γ2	3.4	2021-08-04	doi.org/10.1038/s41422-021-00527-4
	7EXD (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT_1F	Homo sapiens	Lasmiditan	-		3.4	2021-08-04	doi.org/10.1038/s41422-021-00527-4

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