Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.HN.11 4.9075402
2G.HN.43 3.925449
3G.HN.47 3.8975446
4G.S1.02 5.878535
5G.S1.03 4.152519
6G.S1.04 5.4125437
7G.S1.05 5.198519
8G.S1.06 3.865438
9G.S1.07 3.65519
10G.s1h1.06 3.0275409
11G.H1.01 3.61167639
12G.H1.04 4.282537
13G.H1.08 6.7875438
14G.hfs2.07 3.0375419
15G.S2.01 4.426519
16G.S2.06 9.07439
17G.S2.08 7.5875435
18G.S3.01 4.43833634
19G.S3.03 8.302537
20G.S3.04 8.935416
21G.S3.05 4.398537
22G.S3.06 6.09286715
23G.s3h2.03 5.44667619
24G.H2.02 4.395418
25G.H2.04 4.404519
26G.H2.06 5.78111919
27G.H2.07 5.06819
28G.H2.08 4.45418
29G.H2.09 7.14418
30G.H2.10 4.34333617
31G.h2s4.01 5.29222919
32G.h2s4.04 2.815419
33G.S4.02 4.3825418
34G.S4.03 3.8725437
35G.S4.04 5.36333619
36G.S4.05 3.52437
37G.S4.06 4.294517
38G.s4h3.01 5.8775417
39G.s4h3.03 6.87754138
40G.s4h3.04 6.87667618
41G.s4h3.05 7.7525419
42G.H3.09 6.45714719
43G.H3.12 3.31418
44G.H3.13 3.712515
45G.H3.14 7.91408
46G.H3.15 5.5125418
47G.H3.17 8.50833615
48G.H3.18 5.445619
49G.S5.03 3.144538
50G.S5.04 4.86833619
51G.S5.05 4.09286739
52G.S5.06 5.682518
53G.S5.07 4.23439
54G.HG.04 5.10667619
55G.hgh4.01 6.2825416
56G.hgh4.02 5.04571717
57G.hgh4.05 10.5075487
58G.H4.03 6.904504
59G.H4.05 5.7125484
60G.H4.11 2.875417
61G.H4.15 4.22333618
62G.h4s6.02 5.4418
63G.h4s6.04 3.4375404
64G.h4s6.11 4.9417
65G.S6.02 8.76254127
66G.S6.03 8.61415
67G.S6.04 10.4925439
68G.S6.05 5.8325414
69G.s6h5.01 6.365439
70G.H5.04 5.1425437
71G.H5.08 5.07538
72G.H5.14 3.74254127
73G.H5.15 4.074537
74G.H5.20 3.0425409
75G.H5.25 4.62527
76G.H5.26 9.2875405
77b.1x11 4.18408
78b.1x19 5.87466
79b.h2x1 4.705405
80b.h2x5 4.478515
81b.lhb1x3 4.108512
82b.lhb1x6 4.532513
83b.lhb1x9 4.8425413
84b.lhb1x11 5.145414
85b.b1x4 5.9825447
86b.b1x6 8.5325449
87b.l1x3 8.30714749
88b.b2x1 9.524518
89b.b2x3 4.655446
90b.b2x5 6.09647
91b.b3x3 5.054578
92b.b3x6 6.5475449
93b.l3x2 7.53449
94b.b4x2 6.3975408
95b.b4x3 6.472577
96b.b4x4 8.05548
97b.b4x5 4.95577
98b.b4x6 8.4375849
99b.l4x1 4.4125445
100b.b5x2 7.035407
101b.b5x3 6.87143749
102b.b5x5 5.55575
103b.b5x7 6.1175477
104b.l5x1 5.6075478
105b.l5x5 7.79889919
106b.b6x5 4.57876
107b.l6x5 7.575414
108b.b7x1 5.61667614
109b.b7x2 3.968578
110b.b7x4 5.1478
111b.l7x2 4.52857719
112b.b8x3 4.31667616
113b.b8x4 4.63714776
114b.l8x1 3.862575
115b.l8x3 4.50254103
116b.l8x5 3.2054103
117b.l8x8 5.715474
118b.b9x3 5.5525476
119b.l9x3 6.07125819
120b.l9x6 6.43111918
121b.b10x2 4.3375456
122b.b10x4 7.055456
123b.b10x5 5.03125819
124b.l10x1 5.5775453
125b.b11x2 5.41417
126b.b11x3 3.725455
127b.b11x4 7.3419
128b.b11x5 4.2556
129b.l11x2 8.48419
130b.b12x2 4.744517
131b.b12x3 3.736558
132b.b12x5 3.53833656
133b.b12x6 8.60857718
134b.b12x7 6.5375459
135b.l12x1 4.515416
136b.b13x3 7.19414
137b.b13x7 7.63667657
138b.l13x3 8.77333659
139b.l13x6 5.145619
140b.l13x7 4.916559
141b.b14x3 4.826555
142b.b14x5 3.842555
143b.b15x1 7.50333659
144b.b15x2 7.1975466
145b.b15x3 4.915459
146b.l15x1 5.9125417
147b.l15x2 7.3075459
148b.b16x2 4.105455
149b.b16x4 9.832556
150b.b16x5 3.80167665
151b.b16x6 10.564558
152b.b17x5 8.59467
153b.b17x7 6.95571768
154b.l17x3 8.4225869
155b.l17x6 8.852519
156b.b18x3 5.7275468
157b.b18x5 4.86833665
158b.l18x1 5.71571716
159b.l18x2 6.0025417
160b.b19x2 7.17714766
161b.b19x4 5.54568
162b.l19x1 6.455419
163b.l19x2 8.585469
164b.b20x2 7.0775466
165b.b20x4 10.594568
166b.b20x6 7.445666
167b.l20x1 3.215466
168b.l20x2 6.71754119
169b.b21x1 9.2225467
170b.b21x5 7.3675414
171b.b21x7 5.44571715
172b.l21x7 4.9975415
173b.l21x9 6.355416
174b.b22x5 5.282517
175b.l22x3 3.69419
176b.l22x5 6.15167619
177b.b23x1 4.946515
178b.b23x6 7.05429717
179b.b24x3 4.55405
180b.b24x4 6.75416
181b.b24x6 5418
182b.l24x2 4.608516
183b.b25x3 5.478515
184b.l25x3 8.832519
185b.l25x6 12.555418
186b.l26x5 6.275445
187b.b27x3 5.36418
188b.l27x1 11.5957719
189b.l27x2 7.828519
190b.b28x2 5.09414
191b.b28x3 4.41747
192b.b28x4 7.894516
193b.b28x5 4.7125445
194b.b28x6 8.63619
195b.b28x7 7.45449
196g.l1x4 6.09468
197g.h2x9 3.92414
198g.h2x11 9.6725416
199g.h2x12 3.8425417
200g.ctx3 5.77509
201g.ctx4 4.8407
202g.ctx6 4.51667616
203g.ctx15 7.95449
204g.ctx16 5.34778948
205Lig 9.141672420
2061x35 3.7975406
2071x39 4.34333608
2082x42 5.62707
2092x46 5.814529
2102x50 8.28429
2112x53 4.89828
2122x54 4.4275426
2132x57 4.41167628
2142x63 5.9375405
215E1.Y103 5.6025424
216E1x50 8.12286729
217E1x52 7.096508
2183x28 4.05405
2193x30 5.752505
2203x33 5.8425424
2213x34 4.41667625
2223x36 5.7525428
2233x37 4.904527
2243x38 6.184527
2253x42 3.89408
2263x43 4.435428
2273x46 4.87429
2283x49 7.925498
2293x50 6.784529
2303x53 5.5075497
2313x54 3.942528
232I2x57 10.305496
2334x50 6.525429
2344x54 4.9725403
2354x57 4.9225427
2364x61 3.9375425
2374x64 7.31833624
2384x65 7.238525
239E2.T180 2.4825404
240E2x52 7.88425
241E2.F193 13.2625425
2425x29 5.3425404
2435x39 5405
2445x43 5.365625
2455x50 3.502529
2465x58 8.95629
2475x61 2.996528
2485x64 4.245425
2496x32 3.2225427
2506x34 5.075427
2516x36 3.3528
2526x37 6.1425428
2536x40 7.355428
2546x44 5.56167629
2556x48 7.412529
2566x51 7.37426
2576x59 5.8425405
2587x30 6.24525
2597x42 4.538527
2607x49 8.505429
2617x53 6.31629
2628x48 7.4045155
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.b28x3 b.b2x3 10.67962.83YesYes476
2b.b26x2 b.b2x3 21.96376.48NoYes076
3b.b26x1 b.b26x2 22.17243.44NoNo097
4b.b26x1 b.l27x1 22.38354.94NoYes099
5G.H2.10 G.h2s4.01 10.68552.79YesYes179
6G.S1.05 G.h2s4.01 12.748212.18YesYes199
7G.S1.05 G.S1.07 26.98695.54YesYes199
8G.S1.07 G.s1h1.01 66.56131.71YesNo099
9G.H1.01 G.s1h1.01 1005.23YesNo099
10G.H1.01 G.S1.06 98.365.64YesYes398
11G.S1.06 G.S3.05 98.11342.83YesYes387
12G.S1.04 G.S3.05 65.07865.65YesYes377
13G.S1.02 G.S1.04 32.74552.98YesYes357
14G.S1.02 G.S3.01 16.49194.47YesYes354
15G.H5.15 G.S3.01 48.54012.85YesYes374
16G.H5.15 G.H5.19 83.34942.83YesNo078
173x53 G.H5.19 83.16617.45YesNo078
183x49 3x53 81.69284.42YesYes987
192x42 3x49 80.950211.17YesYes078
20G.H3.17 b.l27x1 20.96083.75YesYes159
21G.H3.15 G.H3.17 56.905110.17YesYes185
22G.H3.15 G.H3.18 42.96414.83YesYes189
23G.H3.18 G.S1.05 13.82092.44YesYes199
24G.H3.18 G.S4.02 13.80378.79YesYes198
25G.S1.07 G.S4.02 14.02812.85YesYes198
26G.H3.12 G.H3.18 15.41242.51YesYes189
27G.H3.12 G.S1.07 13.83165.71YesYes189
28G.H2.08 G.H3.15 14.20264.25YesYes188
29G.H2.04 G.H2.08 13.81335.01YesYes198
30G.H2.04 G.H3.08 22.29344.86YesNo099
31G.H3.08 G.s1h1.01 33.43821.71NoNo099
32G.S1.04 G.S3.03 32.65067.31YesYes377
33G.S3.01 G.S3.03 32.92576.09YesYes347
34G.S2.06 G.S3.05 32.75586.22YesYes397
35G.S2.06 G.S3.03 32.691615YesYes397
36G.H5.11 G.S1.02 16.20976.41NoYes385
37G.H5.11 G.H5.15 48.48463.07NoYes387
38G.H5.11 G.S3.03 32.36363.93NoYes387
39G.H5.16 I2x50 13.34186.77NoNo068
40G.H5.15 I2x50 13.52023.39YesNo078
413x54 G.H5.16 11.31214.61YesNo086
422x42 3x46 47.01634.7YesYes079
43b.b20x7 b.b21x4 15.37816.79NoNo095
44b.b20x7 b.l20x3 15.07554.63NoNo097
45b.l20x3 g.h2x1 14.92423.39NoNo078
46b.b21x2 g.h2x1 14.62155.73NoNo068
47b.1x19 b.b21x2 14.47018.18YesNo066
48b.b20x5 b.b21x4 14.05455.54NoNo075
49b.1x19 b.b21x1 10.52548.34YesYes667
50b.l23x1 b.l25x6 27.782919.06NoYes168
51b.l21x7 b.l23x1 27.66516.22YesNo156
52b.b23x6 b.l21x7 26.84874.03YesYes175
53b.b23x6 b.b24x6 24.95026.75YesYes178
54b.b21x7 b.b24x6 24.71413.86YesYes158
55b.b20x5 b.b21x7 17.50687.03NoYes075
563x46 7x53 43.42917.25YesYes299
573x43 7x53 42.55257.03YesYes289
583x43 6x44 40.66642.44YesYes289
596x44 6x48 38.272710.02YesYes299
603x36 6x48 36.78485.82YesYes289
613x36 Lig 28.44056.22YesYes280
622x53 3x35 12.0726.04YesNo088
633x34 3x35 12.82073.83YesNo058
643x34 3x38 25.64055.48YesYes257
653x38 3x42 27.51882.95YesYes078
662x45 3x42 14.69182.75NoYes098
672x45 4x46 15.42527.87NoNo097
682x42 4x46 15.79512.61YesNo077
693x42 4x49 14.6855.71YesNo087
703x45 4x49 15.42254.42NoNo067
712x42 3x45 15.60769.4YesNo076
72G.H3.08 G.S4.04 12.86346.09NoYes099
73G.S1.07 G.S4.04 12.27842.44YesYes199
74b.b2x3 b.b2x5 10.47655.82YesYes467
75G.H3.17 b.l25x6 35.81295YesYes158
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
6x58Lig16.062NoYes4010
6x61Lig14.162NoYes2010
7x30Lig13.452YesYes5010
E2.L183Lig3.652NoYes1010
E2x51Lig27.882NoYes3010
5x36Lig3.052NoYes4010
4x65Lig4.142YesYes5010
E2x52Lig6.172YesYes5010
E2.S188Lig2.892NoYes4010
E1.Y103Lig9.282YesYes4010
7x31Lig2.642NoYes4010
7x34Lig4.022NoYes4010
6x51Lig6.492YesYes6010
2x53Lig3.222YesYes8010
2x57Lig2.442YesYes8010
3x32Lig7.312NoYes6010
3x33Lig8.412YesYes4010
3x36Lig6.222YesYes8010
7x38Lig3.892NoYes6010
7x42Lig2.512YesYes7010
4x61Lig6.522YesYes5010
5x43Lig9.222YesYes5010
1x392x616.040YesNo8722
1x392x642.670YesNo8522
1x397x384.990YesNo8621
1x397x424.840YesYes8721
1x427x424.610NoYes7721
1x432x574.762NoYes6821
1x432x613.272NoNo6722
2x532x543.622YesYes8612
2x532x573.652YesYes8811
2x533x327.312YesNo8611
2x533x356.042YesNo8812
2x533x364.982YesYes8811
2x537x425.022YesYes8711
2x537x465.282YesNo8912
2x547x464.472YesNo6922
2x572x617.142YesNo8712
2x573x322.772YesNo8611
2x577x425.712YesYes8711
2x63E1.Y1034.960YesYes5421
2x63E2.S1883.820YesNo5421
2x64E1.Y10340NoYes5421
7x35E1.Y1034.170NoYes3421
3x294x6516.870NoYes6521
3x304x572.640YesYes5722
3x304x612.640YesYes5521
3x333x372.512YesYes4712
3x334x576.192YesYes4712
3x335x436.262YesYes4511
3x366x485.822YesYes8912
3x366x515.992YesYes8611
3x374x567.312YesNo7522
3x374x575.282YesYes7722
3x375x436.412YesYes7521
4x565x432.432NoYes5521
4x614x653.952YesYes5511
4x615x432.642YesYes5511
4x64E2x524.832YesYes4521
4x64E2.F193152YesYes4522
4x65E2x502.792YesNo5912
4x65E2x528.442YesYes5511
E2.A181E2x512.770NoNo2321
E2.H184E2.L1836.430NoNo2121
E2.S188E2x519.252NoNo4311
E2.F193E2x5212.082YesYes5521
5x36E2.F19318.12NoYes4512
5x39E2.F1937.870YesYes5522
5x366x596.432NoYes4512
5x395x435.230YesYes5521
6x516x526.532YesNo6812
6x516x5510.472YesNo6512
6x547x349.690NoNo4421
6x556x585.260NoNo5421
6x587x3072NoYes4511
6x61E3.T2875.482NoNo2112
6x617x303.392NoYes2511
7x30E3.M2892.492YesNo5312
7x307x344.872YesNo5411
7x317x3232NoNo4112

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
95.45Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
80.95Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
80.95Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
80.95Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
77.27Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
76.00Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
71.43Consensuschemerin_onOrthosteric Ligandcml1_on
65.38Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
65.38Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
57.69Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
57.14Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
56.00Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
56.00Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
55.17Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
55.17Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
55.17Consensusbradykinin_onOrthosteric Ligandbk2_on
55.17Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
55.17Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
53.85Consensusangiotensin_onOrthosteric Ligandat1_on
53.85Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
52.17Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
52.17Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
52.00Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
52.00Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
51.85Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
51.85Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
51.85Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
51.85Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
51.85Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
51.85Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
51.85Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
51.85Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
51.85Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
51.72Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
50.00Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
50.00Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
50.00Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
50.00Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
50.00Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
48.28Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
48.15Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
48.15Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
48.15Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
48.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
47.62Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
46.67Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
46.67Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
46.67Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
46.67Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
46.43Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
46.43Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
46.43Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
46.43Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
46.15Single4IARErgotamine4IAR-5-HT1B-Ergotamine
46.15Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
46.15Single8WDTphotoNECA8WDT-A2A-photoNECA
46.15Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
46.15Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
45.83Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
44.83Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
44.44Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
44.44Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
44.44Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
44.44Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
44.44Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
44.44Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
44.00Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
44.00Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
44.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
44.00Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
44.00Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
43.75Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
43.75Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
43.75Consensusbombesin_onOrthosteric Ligandbb2_on
43.75Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
43.75Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
43.48Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
43.48Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
43.48Single8S4DCMF-0198S4D-Apelin-CMF-019
43.48Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
43.33Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
43.33Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
42.86Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
42.86Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
42.86Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
42.86Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
42.31Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
42.31Single7XN9L-054,5227XN9-SST2-L-054,522
42.31Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
42.31Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
42.31Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
42.31Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
42.31Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
41.94Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
41.67Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
41.67Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
41.67Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
41.67Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
41.67Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
41.38Single6JODAngiotensin II6JOD-AT2-Angiotensin II
41.38Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
41.38Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
40.91Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
40.91Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
40.91Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
40.91Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
40.91Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
40.74Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
40.74Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
40.74Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
40.74Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
40.74Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
40.74Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
40.74Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
40.74Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
40.00Single4RWADIPP-NH24RWA-δ-DIPP-NH2
40.00Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
40.00Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
40.00Single6MXTSalmeterol6MXT-β2-Salmeterol
40.00Single6OS2TRV0266OS2-AT1-TRV026
40.00Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
40.00Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
40.00Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
40.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
40.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
40.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
40.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
40.00Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
40.00Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
40.00Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
40.00Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
40.00Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
40.00Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
39.39Single5GLHEndothelin-15GLH-ETB-Endothelin-1
39.39Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
39.39Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
39.39Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
39.29Single3QAKUK-4320973QAK-A2A-UK-432097
39.29Single6HLOAprepitant6HLO-NK1-Aprepitant
39.29Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
39.29Single7XNACYN1548067XNA-SST2-CYN154806
39.29Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
39.29Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
39.29Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
39.29Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
39.29Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
39.29Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
39.13Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
39.13Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
39.13Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
39.13Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
39.13Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
39.13Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
39.13Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
39.13Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
39.13Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
39.13Consensusa3_onOrthosteric Liganda3a_on
39.13Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
39.13Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
38.71Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
38.71Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
38.71Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
38.71Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
38.46Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
38.46Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
38.46Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
38.46Single6IBLArformoterol6IBL-β1-Arformoterol
38.46Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
38.46Single7EZCUKA7EZC-A2A-UKA
38.46Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
38.46Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
38.46Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
38.46Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
38.46Consensusprostanoid_offOrthosteric Ligandep_off dp_off
38.24Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
38.10Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
37.93Single3OE0CVX153OE0-CXCR4-CVX15
37.93Single5WF5UK-4320975WF5-A2A-UK-432097
37.93Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
37.93Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
37.93Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
37.93Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
37.93Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
37.50Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
37.50Single6D26Fevipiprant6D26-DP2-Fevipiprant
37.50Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
37.50Single7C61Ergotamine7C61-5-HT1B-Ergotamine
37.50Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
37.50Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
37.50Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
37.50Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
37.50Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
37.50Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
37.50Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
37.50Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
37.50Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
37.50Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
37.50Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
37.50Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
37.50Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
37.50Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
37.50Consensusa3_on_gpOrthosteric Liganda3a_on_gp
37.50Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
37.50Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
37.50Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
37.50Consensusdp_offOrthosteric Liganddp2_off
37.50Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
37.50Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
37.50Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
37.50Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
37.50Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
37.50Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
37.50Consensustrace-amine_onOrthosteric Ligandta1_on
37.14Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
37.04Single3NY9ICI118-5513NY9-β2-ICI118-551
37.04Single4UG2CGS216804UG2-A2A-CGS21680
37.04Single5WF6UK-4320975WF6-A2A-UK-432097
37.04Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
37.04Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
37.04Single6PT3DPI-2876PT3-δ-DPI-287
37.04Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
37.04Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
37.04Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
37.04Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
37.04Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
37.04Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
37.04Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
36.67Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
36.67Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
36.67Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
36.67Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
36.67Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
36.36Single6IGLIRL16206IGL-ETB-IRL1620
36.36Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
36.36Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
36.36Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
36.36Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
36.36Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.36Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
36.36Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
36.36Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
36.36Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
36.36Single8GNGIstradefylline8GNG-A2A-Istradefylline
36.36Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
36.36Single8IWESpermidine8IWE-TA9-Spermidine
36.36Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
36.36Single8IY6Endothelin-18IY6-ETB-Endothelin-1
36.36Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
36.36Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
36.36Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
36.36Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
36.36Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
36.36Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
36.36Consensusendothelin_onOrthosteric Ligandetb_on eta_on
36.11Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
36.00Single2YDVNECA2YDV-A2A-NECA
36.00Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
36.00Single4UHRCGS216804UHR-A2A-CGS21680
36.00Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
36.00Single5G53NECA5G53-A2A-NECA-Gs
36.00Single6J21Aprepitant6J21-NK1-Aprepitant
36.00Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
36.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
36.00Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
36.00Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
36.00Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
36.00Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
36.00Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
36.00Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
36.00Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
36.00Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
36.00Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
36.00Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
36.00Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
36.00Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
35.71Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
35.71Single7F8XNN90567F8X-CCKA-NN9056
35.71Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
35.71Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
35.71Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
35.71Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
35.71Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
35.71Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
35.71Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
35.71Consensussomatostatin_offOrthosteric Ligandsst2_off
35.48Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
35.48Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
35.48Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
35.48Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
35.48Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
35.48Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
35.48Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
35.48Single8ZRTET-18ZRT-ETB-ET-1
35.48Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
35.48Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
35.29Single6IGKEndothelin-36IGK-ETB-Endothelin-3
34.78Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
34.78Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
34.78Single6KUXRS-799486KUX-α2a-RS-79948
34.78Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
34.78Single6PS0S-Carazolol6PS0-β2-S-Carazolol
34.78Single6PS4ICI118-5516PS4-β2-ICI118-551
34.78Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
34.78Single7UL3Famotidine7UL3-H2-Famotidine
34.78Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
34.78Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
34.78Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
34.78Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
34.78Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
34.78Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
34.78Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
34.78Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
34.78Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
34.78Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
34.78Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
34.78Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
34.78Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
34.78Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
34.78Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
34.78Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
34.78Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
34.78Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
34.78Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
34.62Single4AMIBucindolol4AMI-β1-Bucindolol
34.62Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
34.62Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
34.62Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
34.62Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
34.62Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
34.62Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
34.62Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
34.62Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
34.62Single8JJ8Formoterol8JJ8-β2-Formoterol
34.62Single8JJLOlodaterol8JJL-β2-Olodaterol
34.62Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
34.62Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
34.62Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
34.62Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
34.62Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
34.62Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
34.62Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
34.62Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
34.62Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
34.62Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
34.48Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
34.48Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
34.48Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
34.48Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
34.48Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
34.38Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
34.38Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
34.38Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
34.29Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
34.29Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
33.33Single2Y04Salbutamol2Y04-β1-Salbutamol
33.33Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
33.33Single3NY8ICI118-5513NY8-β2-ICI118-551
33.33Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
33.33Single4EJ4Naltrindole4EJ4-δ-Naltrindole
33.33Single4GBRS-Carazolol4GBR-β2-S-Carazolol
33.33Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
33.33Single4QKX35V4QKX-β2-35V
33.33Single5X93K-87945X93-ETB-K-8794
33.33Single6D27CAY104716D27-DP2-CAY10471
33.33Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
33.33Single6H7MSalbutamol6H7M-β1-Salbutamol
33.33Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
33.33Single6ME5Agomelatine6ME5-MT1-Agomelatine
33.33Single6PS1Timolol6PS1-β2-Timolol
33.33Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
33.33Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
33.33Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
33.33Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
33.33Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
33.33Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
33.33Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
33.33Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
33.33Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
33.33Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
33.33Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
33.33Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
33.33Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
33.33Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
33.33Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
33.33Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
33.33Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
33.33Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
33.33Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
33.33Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
33.33Single8JXRLSD8JXR-D1-LSD
33.33Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
33.33Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
33.33Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
33.33Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
33.33Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
33.33Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
33.33Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
33.33Single9CHXS-Carazolol9CHX-β2-S-Carazolol
33.33Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
33.33Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
33.33Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
33.33Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
33.33Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
33.33Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
33.33Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
33.33Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
33.33Consensuscck_onOrthosteric Ligandccka_on cckb_on
33.33Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
33.33Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
33.33Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
33.33Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
33.33Consensusdopamine_offOrthosteric Ligandd2_off d3_off
33.33Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
33.33Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
33.33Consensusendothelin_offOrthosteric Ligandetb_off
33.33Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
33.33Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
33.33Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
33.33Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
33.33Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
33.33Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
33.33Consensushca_on_gpOrthosteric Ligandhca2_on_gp
33.33Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
33.33Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
33.33Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
32.35Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
32.26Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
32.26Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
32.26Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
32.26Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
32.26Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
32.26Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
32.14Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
32.14Single6KNMJN241-96KNM-Apelin-JN241-9
32.14Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
32.14Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
32.14Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
32.14Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
32.14Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
32.14Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
32.14Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
32.14Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
32.14Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Single2RH1S-Carazolol2RH1-β2-S-Carazolol
32.00Single2Y03Isoprenaline2Y03-β1-Isoprenaline
32.00Single2YCWS-Carazolol2YCW-β1-S-Carazolol
32.00Single5C1MBU725C1M-μ-BU72
32.00Single5D6LS-Carazolol5D6L-β2-S-Carazolol
32.00Single5JQHS-Carazolol5JQH-β2-S-Carazolol
32.00Single5WQCEMPA5WQC-OX2-EMPA
32.00Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
32.00Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
32.00Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
32.00Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
32.00Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
32.00Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
32.00Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
32.00Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
32.00Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
32.00Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
32.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
32.00Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
32.00Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
32.00Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
32.00Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
32.00Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
32.00Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
32.00Single8ZMFA1L108ZMF-5-HT2C-A1L10
32.00Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
32.00Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
32.00Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
32.00Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
32.00Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
32.00Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
32.00Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
32.00Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
32.00Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
32.00Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
32.00Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
32.00Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
32.00Consensusamine_offonOrthosteric Ligandamine_off amine_on
32.00Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
32.00Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
32.00Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
32.00Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
32.00Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
32.00Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
32.00Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
32.00Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
31.82Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
31.82Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
31.82Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
31.43Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
31.43Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
31.43Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
31.43Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
31.25Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
31.25Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.25Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
31.25Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
31.25Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
31.03Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
31.03Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
31.03Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
31.03Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
31.03Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
31.03Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
30.77Single3P0GBI1671073P0G-β2-BI167107
30.77Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
30.77Single5D5AS-Carazolol5D5A-β2-S-Carazolol
30.77Single5D5BS-Carazolol5D5B-β2-S-Carazolol
30.77Single5XR8AM8415XR8-CB1-AM841
30.77Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
30.77Single6H7JIsoprenaline6H7J-β1-Isoprenaline
30.77Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
30.77Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
30.77Single6OS1TRV0266OS1-AT1-TRV026
30.77Single6WGTLSD6WGT-5-HT2A-LSD
30.77Single7B6WCyclazosin7B6W-α1b-Cyclazosin
30.77Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
30.77Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
30.77Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
30.77Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
30.77Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
30.77Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
30.77Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.77Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
30.77Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
30.77Single8E0GBU728E0G-μ-BU72
30.77Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
30.77Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
30.77Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
30.77Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
30.77Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
30.77Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
30.77Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
30.77Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
30.77Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
30.77Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
30.77Consensusa2_onOrthosteric Liganda2b_on
30.77Consensusa2_on_gpOrthosteric Liganda2b_on_gp
30.77Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
30.77Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
30.77Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
30.77Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
30.77Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
30.77Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
30.77Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
30.77Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
30.77Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
30.77Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
30.77Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
30.77Consensustachykinin_offOrthosteric Ligandnk1_off
30.56Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
30.43Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
30.43Single6AKYMaraviroc6AKY-CCR5-Maraviroc
30.43Single6ME2Ramelteon6ME2-MT1-Ramelteon
30.43Single6ME9Ramelteon6ME9-MT2-Ramelteon
30.43Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
30.43Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
30.43Single6TODEMPA6TOD-OX1-EMPA-Na
30.43Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
30.43Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
30.43Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
30.43Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
30.43Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
30.43Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
30.43Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
30.43Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
30.43Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.43Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
30.43Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
30.43Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
30.43Consensusalpha2_offOrthosteric Ligandalpha2c_off
30.43Consensusangiotensin_offOrthosteric Ligandat1_off
30.43Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
30.30Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
30.30Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
30.30Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
30.30Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
30.30Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
30.00Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
30.00Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
30.00Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
30.00Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
30.00Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
30.00Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
30.00Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
30.00Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
29.63Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
29.63Single3D4STimolol3D4S-β2-Timolol
29.63Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
29.63Single4LDEBI1671074LDE-β2-BI167107
29.63Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
29.63Single6A93Risperidone6A93-5-HT2A-Risperidone
29.63Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
29.63Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
29.63Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
29.63Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
29.63Single6YVRNTS8-136YVR-NTS1-NTS8-13
29.63Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
29.63Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
29.63Single7K15MKD0467K15-BLT1-MKD046-Na
29.63Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
29.63Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
29.63Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.63Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
29.63Single7YITNalfurafine7YIT-κ-Nalfurafine
29.63Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
29.63Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
29.63Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
29.63Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
29.63Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
29.63Single8XWSCXCL58XWS-CXCR2-CXCL5
29.63Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
29.63Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
29.63Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
29.63Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
29.63Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
29.63Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
29.63Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
29.63Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
29.63Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
29.63Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
29.63Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
29.63Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
29.63Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
29.63Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
29.63Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
29.63Consensuslpa_offOrthosteric Ligandlpa1_off
29.63Consensuslpl_offOrthosteric Ligands1p_off lpa_off
29.63Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
29.63Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
29.63Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
29.63Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
29.63Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
29.63Consensusorexin_onOrthosteric Ligandox2_on
29.63Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
29.63Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
29.41Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
29.41Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
29.41Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
29.41Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
29.17Single2YDOAdenosine2YDO-A2A-Adenosine
29.17Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
29.17Single4MBSMaraviroc4MBS-CCR5-Maraviroc
29.17Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
29.17Single4ZJCSB-6740424ZJC-OX1-SB-674042
29.17Single6MH8ZM-2413856MH8-A2A-ZM-241385
29.17Single6PS5S-Propranolol6PS5-β2-S-Propranolol
29.17Single7AROLUF58337ARO-A2A-LUF5833-Na
29.17Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
29.17Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
29.17Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
29.17Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
29.17Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
29.17Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
29.17Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.17Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
29.17Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
29.17Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
29.17Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
29.17Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
29.17Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
29.17Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
29.17Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
29.17Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
29.17Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
29.17Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
29.17Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
29.17Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
29.17Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
29.17Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
29.17Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
29.17Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
29.17Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.17Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.17Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
29.17Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.17Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
29.17Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
29.17Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
29.17Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
29.17Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
29.17Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
29.17Consensusalpha1_onOrthosteric Ligandalpha1a_on
29.17Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
29.17Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
29.17Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
29.17Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
29.17Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
29.17Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
29.17Consensushca_onOrthosteric Ligandhca2_on
29.17Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
29.03Single6PT2KGCHM076PT2-δ-KGCHM07
29.03Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
29.03Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
29.03Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
29.03Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
29.03Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
29.03Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
29.03Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
29.03Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
29.03Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
28.57Single4BUONeurotensin4BUO-NTS1-Neurotensin
28.57Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
28.57Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
28.57Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
28.57Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
28.57Single6H7LDobutamine6H7L-β1-Dobutamine
28.57Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
28.57Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
28.57Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
28.57Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
28.57Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
28.57Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
28.57Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
28.57Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.57Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
28.57Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.57Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
28.57Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
28.57Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
28.57Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
28.57Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
28.57Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
28.57Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
28.57Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
28.57Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
28.57Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
28.57Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
28.57Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
28.57Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
28.57Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
28.57Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
28.57Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
28.57Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
28.12Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
28.12Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
28.12Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
28.12Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
28.12Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
28.12Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
28.12Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
28.12Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
28.12Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
28.12Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
28.12Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
28.12Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
28.12Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
28.12Consensusvasop-oxy_onOrthosteric Ligandv2_on
28.12Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
28.00Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
28.00Single2Y01Dobutamine2Y01-β1-Dobutamine
28.00Single2Y02Carmoterol2Y02-β1-Carmoterol
28.00Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
28.00Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
28.00Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
28.00Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
28.00Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
28.00Single4YAYZD-71554YAY-AT1-ZD-7155
28.00Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
28.00Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
28.00Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
28.00Single7BU7BI1671077BU7-β1-BI167107
28.00Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
28.00Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
28.00Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
28.00Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
28.00Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
28.00Single7UL4Alvimopan7UL4-μ-Alvimopan
28.00Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
28.00Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
28.00Single7V3ZCP559407V3Z-CB1-CP55940
28.00Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
28.00Single7WC7Lisuride7WC7-5-HT2A-Lisuride
28.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
28.00Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
28.00Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
28.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
28.00Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
28.00Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
28.00Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
28.00Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
28.00Single8JJOAlprenolol8JJO-β2-Alprenolol
28.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
28.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
28.00Single8K5DGSK2560738K5D-HCA2-GSK256073
28.00Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
28.00Single8T1WCVN4248T1W-GPR6-CVN424
28.00Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
28.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
28.00Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
28.00Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
28.00Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
28.00Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
28.00Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
28.00Consensus5ht5_onOrthosteric Ligand5ht5a_on
28.00Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
28.00Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
28.00Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
28.00Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
28.00Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
27.59Single5EE7MK08935EE7-Glucagon-MK0893
27.59Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
27.59Single5ZTYAM102575ZTY-CB2-AM10257
27.59Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
27.59Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
27.59Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
27.59Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
27.59Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
27.59Single7SK9CCX6627SK9-ACKR3-CCX662
27.59Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
27.59Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
27.59Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
27.59Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
27.59Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
27.59Single8XQJJN2418XQJ-Apelin-JN241
27.59Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
27.59Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
27.59Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
27.59Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
27.50Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
27.50Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
27.27Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
27.27Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
27.27Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
27.27Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
27.27Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
27.27Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
27.27Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
27.27Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
27.27Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.27Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
27.27Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
27.27Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
27.27Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
27.27Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
27.27Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
27.27Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
27.27Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
27.27Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
27.27Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
27.27Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
27.27Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
27.27Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
27.27Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
27.03Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
27.03Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
27.03Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
26.92Single2Y00Dobutamine2Y00-β1-Dobutamine
26.92Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
26.92Single5N2RPSB-365N2R-A2A-PSB-36-Na
26.92Single5N2SPSB365N2S-A1-PSB36
26.92Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
26.92Single5TVNLSD5TVN-5-HT2B-LSD
26.92Single5WIUNemonapride5WIU-D4-Nemonapride
26.92Single5WIVNemonapride5WIV-D4-Nemonapride-Na
26.92Single6E67BI1671076E67-β2-BI167107-Gs (fused)
26.92Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
26.92Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
26.92Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
26.92Single6PS6Timolol6PS6-β2-Timolol
26.92Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
26.92Single6TP6Filorexant6TP6-OX1-Filorexant
26.92Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
26.92Single7W41PD1762527W41-BB2-PD176252
26.92Single7WC6LSD7WC6-5-HT2A-LSD
26.92Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
26.92Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
26.92Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
26.92Single8JXSPF-61428JXS-D1-PF-6142
26.92Single8QOTNanobody-E8QOT-μ-Nanobody-E
26.92Single8TF5Oleic acid8TF5-GPR6-Oleic acid
26.92Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
26.92Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
26.92Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
26.92Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
26.92Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
26.92Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
26.92Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
26.92Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
26.92Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
26.92Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
26.92Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
26.92Consensusbombesin_offOrthosteric Ligandbb2_off
26.92Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
26.92Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
26.92Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
26.92Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
26.92Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
26.92Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
26.92Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
26.67Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
26.67Single7QA8Peptide7QA8-STE2-Peptide
26.67Single7QA8Peptide7QA8-STE2-Peptide
26.67Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
26.67Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
26.67Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
26.67Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
26.67Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
26.67Single8XWNCXCL88XWN-CXCR2-CXCL8
26.67Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Consensuslpl_onOrthosteric Ligands1p_on lpa_on
26.67Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
26.67Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
26.67Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
26.47Single4XT3Fractalkine4XT3-US28-Fractalkine
26.47Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
26.47Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
26.47Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
26.47Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
26.47Single7SK3CXCL127SK3-ACKR3-CXCL12
26.47Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
26.47Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
26.47Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
26.47Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
26.32Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
26.32Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
26.09Single3PBLEticlopride3PBL-D3-Eticlopride
26.09Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
26.09Single6HLLCP999946HLL-NK1-CP99994
26.09Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
26.09Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
26.09Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
26.09Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
26.09Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
26.09Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
26.09Single8K5BNiacin8K5B-HCA2-Niacin
26.09Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
26.09Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
26.09Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
26.09Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
26.09Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.09Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
26.09Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
26.09Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
26.09Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
26.09Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
26.09Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
26.09Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
26.09Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
26.09Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
26.09Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
26.09Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
25.93Single4U15Tiotropium4U15-M3-Tiotropium
25.93Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
25.93Single5V54Methiothepin5V54-5-HT1B-Methiothepin
25.93Single5XRAAM115425XRA-CB1-AM11542
25.93Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
25.93Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
25.93Single6J20Aprepitant6J20-NK1-Aprepitant
25.93Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
25.93Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
25.93Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
25.93Single6OL9Tiotropium6OL9-M5-Tiotropium
25.93Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
25.93Single6TQ7SB-3348676TQ7-OX1-SB-334867
25.93Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
25.93Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
25.93Single7F1TMIP-1a7F1T-CCR5-MIP-1a
25.93Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
25.93Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
25.93Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
25.93Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
25.93Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.93Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
25.93Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
25.93Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
25.93Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
25.93Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
25.93Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
25.93Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
25.93Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.93Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
25.93Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
25.93Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
25.93Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
25.93Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
25.93Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
25.93Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.93Single8XVLZibotentan8XVL-ETA-Zibotentan
25.93Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
25.93Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
25.93Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
25.93Consensus5ht1_offOrthosteric Ligand5ht1b_off
25.93Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
25.93Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
25.93Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.93Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
25.93Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
25.93Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
25.93Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
25.93Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
25.93Consensusneurotensin_onOrthosteric Ligandnts1_on
25.93Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
25.93Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
25.93Consensusrelaxin_onOrthosteric Ligandrxfp4_on
25.93Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
25.93Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
25.93Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
25.81Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
25.81Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
25.81Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
25.81Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
25.81Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
25.81Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
25.81Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
25.81Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
25.71Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
25.71Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
25.71Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
25.71Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
25.64Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
25.64Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
25.00Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
25.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
25.00Single4N4WSANT-14N4W-SMO-SANT-1
25.00Single4XEENeurotensin4XEE-NTS1-Neurotensin
25.00Single4XESNeurotensin4XES-NTS1-Neurotensin
25.00Single5CXVTiotropium5CXV-M1-Tiotropium
25.00Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
25.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
25.00Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
25.00Single5WS3EMPA5WS3-OX2-EMPA
25.00Single6AKXA4R6AKX-CCR5-A4R
25.00Single6CM4Risperidone6CM4-D2-Risperidone
25.00Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
25.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
25.00Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
25.00Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
25.00Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
25.00Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
25.00Single6W25SHU91196W25-MC4-SHU9119-Ca
25.00Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
25.00Single7DFPSpiperone7DFP-D2-Spiperone
25.00Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
25.00Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
25.00Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
25.00Single7F8ULintitript7F8U-CCKA-Lintitript
25.00Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
25.00Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
25.00Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
25.00Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
25.00Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
25.00Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
25.00Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
25.00Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
25.00Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
25.00Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
25.00Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
25.00Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
25.00Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
25.00Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
25.00Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
25.00Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
25.00Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
25.00Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
25.00Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
25.00Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
25.00Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
25.00Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
25.00Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
25.00Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
25.00Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
25.00Single8XQJJN2418XQJ-Apelin-JN241
25.00Single8XWACXCL18XWA-CXCR2-CXCL1
25.00Single8XWMCXCL68XWM-CXCR2-CXCL6
25.00Single8XYIVUF106618XYI-CXCR3-VUF10661
25.00Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
25.00Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
25.00Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
25.00Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
25.00Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
25.00Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
25.00Consensusalpha1_offOrthosteric Ligandalpha1a_off
25.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
25.00Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
25.00Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
25.00Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
25.00Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
25.00Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
25.00Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
25.00Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
25.00Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
25.00Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
25.00Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
25.00Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
25.00Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
25.00Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
25.00Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
25.00Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
25.00Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
25.00Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
25.00Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
25.00Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusorexin_offOrthosteric Ligandox2_off ox1_off
25.00Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
25.00Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
25.00Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
25.00Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
24.32Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
24.32Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
24.32Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
24.24Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
24.24Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
24.24Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
24.24Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
24.24Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
24.24Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
24.24Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
24.14Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
24.14Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
24.14Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
24.14Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
24.14Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
24.14Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
24.14Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
24.14Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
24.14Single7UM4AS26747237UM4-5-HT5A-AS2674723
24.14Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
24.14Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
24.14Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.14Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
24.14Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
24.14Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
24.14Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
24.14Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
24.14Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
24.14Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
24.14Single8XVJMacitentan8XVJ-ETA-Macitentan
24.14Single8XVUCXCL28XVU-CXCR2-CXCL2
24.14Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
24.14Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
24.14Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
24.14Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
24.14Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
24.14Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
24.14Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
24.00Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
24.00Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
24.00Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
24.00Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
24.00Single6A94Zotepine6A94-5-HT2A-Zotepine
24.00Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
24.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
24.00Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
24.00Single6TPGEMPA6TPG-OX2-EMPA
24.00Single6TPNHTL66416TPN-OX2-HTL6641
24.00Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
24.00Single6V9SGTPL114036V9S-OX1-GTPL11403
24.00Single6VI4JDTic6VI4-κ-JDTic
24.00Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
24.00Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
24.00Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
24.00Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
24.00Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
24.00Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
24.00Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
24.00Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
24.00Single7T32ZM-2413857T32-A2A-ZM-241385
24.00Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
24.00Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
24.00Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
24.00Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
24.00Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
24.00Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.00Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
24.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Single8IHKAcifran8IHK-HCA3-Acifran
24.00Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
24.00Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
24.00Single8K5CAcipimox8K5C-HCA2-Acipimox
24.00Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
24.00Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
24.00Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
24.00Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
24.00Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
24.00Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
24.00Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
24.00Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
24.00Single9BJKNaloxone9BJK-μ-Naloxone-NAM
24.00Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
24.00Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
24.00Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
24.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
23.91Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
23.68Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
23.68Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
23.53Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
23.53Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
23.53Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
23.53Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
23.53Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
23.53Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
23.33Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
23.33Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
23.33Single8QJ2pN1628QJ2-MC4-pN162-Gs
23.33Single8X5YAstemizole8X5Y-H1-Astemizole
23.33Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
23.33Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
23.33Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
23.33Consensuskisspeptin_onOrthosteric Ligandkiss1_on
23.33Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
23.33Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
23.08Single3EMLZM-2413853EML-A2A-ZM-241385
23.08Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
23.08Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
23.08Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
23.08Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
23.08Single5TGZAM65385TGZ-CB1-AM6538
23.08Single5UENDU1725UEN-A1-DU172
23.08Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
23.08Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
23.08Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
23.08Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
23.08Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
23.08Single6DRXLisuride6DRX-5-HT2B-Lisuride
23.08Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
23.08Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
23.08Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
23.08Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
23.08Single6S0LZM-2413856S0L-A2A-ZM-241385
23.08Single6TOTLemborexant6TOT-OX1-Lemborexant
23.08Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
23.08Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
23.08Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
23.08Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
23.08Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
23.08Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
23.08Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
23.08Single8CU6LJ-45178CU6-A2A-LJ-4517
23.08Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
23.08Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
23.08Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
23.08Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
23.08Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
23.08Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
23.08Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
23.08Single8X64Desloratadine8X64-H1-Desloratadine
23.08Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
23.08Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
23.08Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.08Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
23.08Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
23.08Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
23.08Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
23.08Consensusalpha2_onOrthosteric Ligandalpha2b_on
23.08Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
23.08Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
23.08Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
23.08Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
23.08Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
23.08Consensusblt_onOrthosteric Ligandblt1_on
23.08Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
23.08Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
23.08Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
23.08Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
23.08Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
23.08Consensusleukotriene_onOrthosteric Ligandblt_on
23.08Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
23.08Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
23.08Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
22.86Single6FJ3PTH6FJ3-PTH1-PTH
22.86Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
22.86Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
22.86Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
22.86Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
22.86Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
22.86Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
22.73Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
22.73Single8A2OTheophylline8A2O-A2A-Theophylline-Na
22.73Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
22.73Single9CHUNoradrenaline9CHU-β2-Noradrenaline
22.73Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
22.73Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
22.73Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
22.73Consensussensory_onOrthosteric Ligandopsins_on
22.58Single4XT1Fractalkine4XT1-US28-Fractalkine
22.58Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
22.58Single8IEBA1LYA8IEB-GPR156-A1LYA
22.58Single8IEIA1LYA8IEI-GPR156-A1LYA
22.58Single8IEPA1LYA8IEP-GPR156-A1LYA
22.58Single8WKYPG-9348WKY-MC4-PG-934
22.58Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.58Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
22.58Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
22.58Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
22.58Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
22.58Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
22.58Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
22.58Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
22.50Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
22.50Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.22Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
22.22Single5CGCHTL142425CGC-mGlu5-HTL14242
22.22Single5IUAQ274563485IUA-A2A-Q27456348-Na
22.22Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
22.22Single5XPRBosentan5XPR-ETB-Bosentan
22.22Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
22.22Single6HLPNetupitant6HLP-NK1-Netupitant
22.22Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
22.22Single6LUQHaloperidol6LUQ-D2-Haloperidol
22.22Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
22.22Single6S0QZM-2413856S0Q-A2A-ZM-241385
22.22Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
22.22Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
22.22Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
22.22Single6Z4SSR486926Z4S-NTS1-SR48692
22.22Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
22.22Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
22.22Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
22.22Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
22.22Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
22.22Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
22.22Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
22.22Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
22.22Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
22.22Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
22.22Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
22.22Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
22.22Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
22.22Single8GNEKW-63568GNE-A2A-KW-6356-Na
22.22Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
22.22Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
22.22Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
22.22Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
22.22Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Consensusadenosine_offOrthosteric Liganda1_off a2_off
22.22Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
22.22Consensusblt_offOrthosteric Ligandblt1_off
22.22Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
22.22Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
22.22Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
22.22Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
22.22Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
22.22Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
21.95Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
21.88Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
21.88Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
21.88Single7SK5CXCL127SK5-ACKR3-CXCL12
21.88Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
21.88Single8IEBA1LYA8IEB-GPR156-A1LYA
21.88Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
21.74Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
21.74Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
21.74Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
21.74Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
21.74Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
21.74Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
21.74Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.74Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
21.74Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
21.74Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
21.74Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
21.74Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
21.74Consensus5ht2_onOrthosteric Ligand5ht2b_on
21.74Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
21.74Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
21.74Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
21.74Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
21.62Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
21.62Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
21.62Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
21.62Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
21.62Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
21.62Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
21.43Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
21.43Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
21.43Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
21.43Single4DJHJDTic4DJH-κ-JDTic
21.43Single5TZRMK86665TZR-FFA1-MK8666
21.43Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
21.43Single6E59L-7607356E59-NK1-L-760735
21.43Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
21.43Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
21.43Single7FEECP559407FEE-CB1-CP55940-ZCZ011
21.43Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
21.43Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
21.43Single7PX4PSB-21137PX4-A2A-PSB-2113
21.43Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
21.43Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
21.43Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
21.43Single7TUYGSK682753A7TUY-GPR183-GSK682753A
21.43Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
21.43Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
21.43Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
21.43Single8EA0Iperoxo8EA0-M3-Iperoxo
21.43Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
21.43Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
21.43Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
21.43Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
21.43Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
21.43Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
21.43Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
21.43Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
21.43Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
21.43Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
21.43Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
21.43Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
21.43Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
21.43Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
21.43Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
21.43Consensuslpa_onOrthosteric Ligandlpa1_on
21.43Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
21.43Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
21.43Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
21.43Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
21.43Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
21.21Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
21.21Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
21.21Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
20.83Single3OE9IT1t3OE9-CXCR4-IT1t
20.83Single5L7IVismodegib5L7I-SMO-Vismodegib
20.83Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
20.83Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
20.83Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
20.83Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
20.83Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
20.83Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
20.83Single7SRQLSD7SRQ-5-HT2B-LSD
20.83Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
20.83Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
20.83Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
20.83Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
20.83Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
20.83Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
20.83Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
20.83Single9B9Y7DY9B9Y-CB1-7DY
20.83Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
20.83Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
20.83Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
20.69Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
20.69Single4PY02MeSATP4PY0-P2Y12-2MeSATP
20.69Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
20.69Single6KQICP559406KQI-CB1-CP55940-Org27569
20.69Single6ZG4HTL00099366ZG4-M1-HTL0009936
20.69Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
20.69Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
20.69Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
20.69Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
20.69Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
20.69Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
20.69Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.69Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
20.69Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single8JWY2-1188JWY-A2A-2-118
20.69Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
20.69Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
20.69Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
20.69Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
20.59Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
20.59Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
20.59Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
20.59Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
20.59Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
20.59Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
20.51Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
20.00Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
20.00Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
20.00Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
20.00Single3PWHZM-2413853PWH-A2A-ZM-241385
20.00Single4BWBNeurotensin4BWB-NTS1-Neurotensin
20.00Single4S0VSuvorexant4S0V-OX2-Suvorexant
20.00Single5CGDHTL142425CGD-mGlu5-HTL14242
20.00Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
20.00Single5U09Taranabant5U09-CB1-Taranabant
20.00Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
20.00Single6B73MP11046B73-κ-MP1104
20.00Single6DS0Ly2660976DS0-5-HT2B-Ly266097
20.00Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
20.00Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
20.00Single6TPJSuvorexant6TPJ-OX2-Suvorexant
20.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
20.00Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
20.00Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
20.00Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
20.00Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
20.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
20.00Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
20.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
20.00Single7XRRLemborexant7XRR-OX2-Lemborexant
20.00Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
20.00Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
20.00Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
20.00Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
20.00Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
20.00Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
20.00Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
20.00Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
20.00Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8XWFCXCL38XWF-CXCR2-CXCL3
20.00Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
20.00Single8Y0HVUF114188Y0H-CXCR3-VUF11418
20.00Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
20.00Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
20.00Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
20.00Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
20.00Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
20.00Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
20.00Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
20.00Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
20.00Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
20.00Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
20.00Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
19.51Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
19.35Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
19.35Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
19.35Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
19.35Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
19.35Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
19.35Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
19.23Single3REYXAC3REY-A2A-XAC
19.23Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
19.23Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
19.23Single5IU7Q274563465IU7-A2A-Q27456346-Na
19.23Single5IUBQ274563445IUB-A2A-Q27456344-Na
19.23Single5JTBZM-2413855JTB-A2A-ZM-241385
19.23Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
19.23Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
19.23Single5UVIZM-2413855UVI-A2A-ZM-241385
19.23Single6AQFZM-2413856AQF-A2A-ZM-241385
19.23Single6TP3Nemorexant6TP3-OX1-Nemorexant
19.23Single6TPKRetosiban6TPK-OT-Retosiban
19.23Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
19.23Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
19.23Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
19.23Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
19.23Single6ZINSR486926ZIN-NTS1-SR48692
19.23Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
19.23Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
19.23Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
19.23Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
19.23Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
19.23Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
19.23Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
19.23Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
19.23Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
19.23Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
19.23Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
19.23Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
19.23Consensusa2_offOrthosteric Liganda2a_off
19.23Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
19.23Consensusopsins_offOrthosteric Ligandrhodopsin_off
19.23Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
19.23Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
19.23Consensussensory_offOrthosteric Ligandopsins_off
19.23Consensusvasop-oxy_offOrthosteric Ligandot_off
19.05Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
19.05Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
18.92Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
18.92Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
18.92Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
18.92Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
18.92Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
18.92Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
18.92Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
18.75Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
18.75Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
18.75Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
18.75Single8IEPA1LYA8IEP-GPR156-A1LYA
18.75Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
18.75Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
18.75Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
18.75Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
18.52Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
18.52Single4DAJTiotropium4DAJ-M3-Tiotropium
18.52Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
18.52Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
18.52Single4MQSIperoxo4MQS-M2-Iperoxo
18.52Single4QIMANTA XV4QIM-SMO-ANTA XV
18.52Single4U14Tiotropium4U14-M3-Tiotropium
18.52Single5DHHSB-6121115DHH-NOP-SB-612111
18.52Single5DSGTiotropium5DSG-M4-Tiotropium
18.52Single5IU8Q274563475IU8-A2A-Q27456347-Na
18.52Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
18.52Single5T04Neurotensin5T04-NTS1-Neurotensin
18.52Single5UIGCmpd-15UIG-A2A-Cmpd-1
18.52Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
18.52Single6IIVDaltroban6IIV-TP-Daltroban
18.52Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.52Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
18.52Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
18.52Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
18.52Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
18.52Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
18.52Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
18.52Single7PYRPSB-21157PYR-A2A-PSB-2115
18.52Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
18.52Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
18.52Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
18.52Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
18.52Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
18.52Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
18.52Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
18.52Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.52Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
18.52Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
18.52Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
18.52Single8RLNLUF58348RLN-A2A-LUF5834
18.52Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
18.52Single8X63Mepyramine8X63-H1-Mepyramine
18.52Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
18.52Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
18.52Single9B9ZA1AKO9B9Z-CB1-A1AKO
18.52Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
18.52Single9IYAONO-97105319IYA-GPR55-ONO-9710531
18.52Consensuscck_offOrthosteric Ligandccka_off
18.52Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
18.52Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
18.52Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
18.52Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
18.52Consensushistamine_offOrthosteric Ligandh1_off
18.52Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
18.52Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
18.42Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
18.42Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
18.42Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
18.42Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
18.18Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
18.18Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
18.18Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
18.18Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
18.18Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
18.18Single7WC4Serotonin7WC4-5-HT2A-Serotonin
18.18Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
18.18Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
18.18Single8PWNTheophylline8PWN-A2A-Theophylline
18.18Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
18.18Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
18.18Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
17.86Single4NTJAZD12834NTJ-P2Y12-AZD1283
17.86Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
17.86Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
17.86Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
17.86Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
17.86Single7SINNPS-21437SIN-CaS-NPS-2143
17.86Single7SINNPS-21437SIN-CaS-NPS-2143
17.86Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
17.86Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
17.86Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
17.86Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.86Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
17.86Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
17.86Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
17.86Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
17.86Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
17.86Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
17.86Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
17.86Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
17.78Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
17.65Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
17.65Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
17.65Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.65Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
17.65Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
17.50Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
17.39Single3RFMCaffeine3RFM-A2A-Caffeine
17.39Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
17.39Single6TQ9SB-4081246TQ9-OX1-SB-408124
17.39Consensusp2y_offOrthosteric Ligandp2y1_off
17.24Single4BV0Neurotensin4BV0-NTS1-Neurotensin
17.24Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
17.24Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
17.24Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
17.24Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
17.24Single7R0CAVP7R0C-V2-AVP-Arrestin2
17.24Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
17.24Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
17.24Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
17.24Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.24Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
17.24Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
17.24Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
17.24Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
17.14Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
16.67Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
16.67Single3OE6IT1t3OE6-CXCR4-IT1t
16.67Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
16.67Single3UZAGTPL92363UZA-A2A-GTPL9236
16.67Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
16.67Single4XNWMRS25004XNW-P2Y1-MRS2500
16.67Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
16.67Single6IIURamatroban6IIU-TP-Ramatroban
16.67Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
16.67Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
16.67Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
16.67Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
16.67Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
16.67Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
16.67Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
16.67Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
16.67Single7WC5Psilocin7WC5-5-HT2A-Psilocin
16.67Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
16.67Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
16.67Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
16.67Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
16.67Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
16.67Single8JWZAB9288JWZ-A2A-AB928-Na
16.67Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
16.67Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
16.67Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
16.67Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
16.67Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
16.67Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
16.67Consensusgi_sensoryOrthosteric Ligandgi_opsins
16.67Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
16.67Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
16.67Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
16.67Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
16.13Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
16.13Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
16.13Single6K1QIRL25006K1Q-ETB-IRL2500
16.13Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
16.13Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
16.13Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
16.13Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
16.13Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
16.13Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
16.13Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
16.00Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
16.00Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
16.00Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
16.00Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
16.00Single6TP4ACT-4622066TP4-OX1-ACT-462206
16.00Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
16.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
16.00Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
16.00Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
16.00Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
16.00Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
16.00Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
16.00Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
16.00Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
16.00Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.00Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
16.00Consensusgq_nucleotideOrthosteric Ligandgq_p2y
16.00Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
15.79Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
15.79Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
15.62Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
15.62Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.62Single8IEIA1LYA8IEI-GPR156-A1LYA
15.62Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
15.62Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
15.38Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
15.38Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
15.38Single3ODUIT1t3ODU-CXCR4-IT1t
15.38Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
15.38Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
15.38Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
15.38Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
15.38Single5ZKQABT-4915ZKQ-PAF-ABT-491
15.38Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
15.38Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
15.38Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
15.38Single7BR3Elagolix7BR3-GnRH1-Elagolix
15.38Single7F8YDevazepide7F8Y-CCKA-Devazepide
15.38Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
15.38Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
15.38Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
15.38Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
15.38Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
15.38Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
15.38Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
15.38Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
15.38Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
15.38Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
15.38Single9BA0A1AKN9BA0-CB1-A1AKN
15.38Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
15.38Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
15.38Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
15.38Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
15.38Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
15.15Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
15.15Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
15.15Single8KIGSHU91198KIG-MC3-SHU9119-Ca
15.00Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
14.89Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
14.81Single3RZECidoxepin3RZE-H1-Cidoxepin
14.81Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
14.81Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
14.81Single6IQLL7458706IQL-D4-L745870
14.81Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
14.81Single6ZG9GSK10347026ZG9-M1-GSK1034702
14.81Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
14.81Single7VODCariprazine7VOD-5-HT2A-Cariprazine
14.81Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
14.81Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
14.81Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
14.81Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Consensusgrh_offOrthosteric Ligandgnrh1_off
14.81Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
14.71Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
14.71Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
14.71Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
14.63Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
14.63Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
14.29Single5DHGC-355DHG-NOP-C-35
14.29Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
14.29Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
14.29Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
14.29Single6GPSMK08126GPS-CCR2-MK0812
14.29Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
14.29Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
14.29Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
14.29Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
14.29Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
14.29Single7YXAONO-54306087YXA-S1P5-ONO-5430608
14.29Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
14.29Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
14.29Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
14.29Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
14.29Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
14.29Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
13.95Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
13.89Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
13.79Single4JKVTaladegib4JKV-SMO-Taladegib
13.79Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
13.79Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
13.79Single6GPXMK08126GPX-CCR2-MK0812
13.79Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
13.79Single7C4SS1P7C4S-S1P3-S1P
13.79Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
13.79Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
13.79Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
13.79Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
13.79Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
13.79Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
13.79Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
13.79Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
13.79Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
13.79Consensusep_offOrthosteric Ligandep4_off
13.64Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
13.64Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
13.64Single5MZPCaffeine5MZP-A2A-Caffeine-Na
13.64Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
13.51Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
13.51Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
13.33Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
13.33Single5V56TC1145V56-SMO-TC114
13.33Single5V57TC1145V57-SMO-TC114
13.33Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
13.33Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
13.33Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
13.33Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
13.04Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
12.90Single5X33BIIL2605X33-BLT1-BIIL260
12.90Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
12.90Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
12.90Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.90Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
12.90Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
12.90Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
12.90Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
12.50Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
12.50Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
12.50Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
12.50Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
12.12Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
12.12Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
12.00Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
12.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
12.00Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
11.76Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
11.76Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
11.76Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
11.76Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
11.76Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
11.54Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
11.54Single4O9RCyclopamine4O9R-SMO-Cyclopamine
11.54Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
11.54Single6LI0C176LI0-GPR52-C17
11.54Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
11.54Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
11.54Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
11.54Single7UL2SR486927UL2-NTS1-SR48692-Na
11.54Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
11.54Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
11.54Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
11.54Consensusneurotensin_offOrthosteric Ligandnts1_off
11.54Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
11.43Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
11.11Single4QINSAG1.54QIN-SMO-SAG1.5
11.11Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
11.11Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
11.11Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
11.11Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
11.11Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
11.11Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
11.11Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
11.11Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
11.11Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
11.11Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
11.11Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
11.11Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
11.11Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
11.11Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
11.11Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
11.11Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
10.81Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
10.71Single6FFIMMPEP6FFI-mGlu5-MMPEP
10.71Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
10.71Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
10.71Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
10.71Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
10.71Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
10.71Single8K2WAMG4878K2W-CXCR3-AMG487
10.71Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.71Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
10.71Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.71Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
10.71Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
10.71Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
10.34Single6FFHFenobam6FFH-mGlu5-Fenobam
10.34Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
10.34Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
10.34Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
10.34Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
10.34Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
10.00Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
10.00Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
10.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
10.00Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
10.00Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
10.00Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Single7P2L4YI7P2L-mGlu5-4YI
9.68Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
9.68Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
9.68Single9BJKNAM9BJK-μ-Naloxone-NAM
9.38Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
8.57Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
8.33Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
8.33Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
8.00Single3OE8IT1t3OE8-CXCR4-IT1t
8.00Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
8.00Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
8.00Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
8.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
7.69Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
7.69Single8JPSCCL78JPS-ACKR1-CCL7
7.69Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
7.69Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
7.69Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
7.41Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.41Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
7.41Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
7.41Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.41Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
7.41Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
7.14Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.14Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
7.14Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
7.14Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
7.14Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
6.90Single7VV6C48/807VV6-MRGPRX2-C48/80
6.90Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single7F83PF-051904577F83-Ghrelin-PF-05190457
6.67Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
6.45Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
6.45Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
6.06Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
6.06Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
5.41Single7SHEPI; PE7SHE-GPR158-PI; PE
4.35Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
4.00Single8HS2Fab0468HS2-GPR20-Fab046
4.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
4.00Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
4.00Single9GE2Cholesterol9GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
3.70Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
3.70Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
3.70Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
3.57Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
3.57Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
3.57Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
3.57Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
3.57Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
3.45Single8G94CD698G94-S1P1-CD69-Gi1/β1/γ2
3.33Single8IYXYL-3658IYX-GPR34-YL-365
3.23Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
3.12Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
3.03Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
2.94Single7SHEPI; PE7SHE-GPR158-PI; PE
2.86Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.63Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7

Consensus Members
Id Members
7YKD 7YKD-CML1-Chemerin-9-Gi1/β1/γ2
Net Summary
Imin 2.43
Number of Linked Nodes 855
Number of Links 1233
Number of Hubs 262
Number of Links mediated by Hubs 899
Number of Communities 16
Number of Nodes involved in Communities 372
Number of Links involved in Communities 639
Path Summary
Number Of Nodes in MetaPath 76
Number Of Links MetaPath 75
Number of Shortest Paths 11350959
Length Of Smallest Path 3
Average Path Length 30.2962
Length of Longest Path 55
Minimum Path Strength 1.23
Average Path Strength 5.27546
Maximum Path Strength 23.84
Minimum Path Correlation 0.7
Average Path Correlation 0.996626
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.43902
Average % Of Corr. Nodes 35.7836
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 67.974
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
chemerin_on_gpcml1_on_gp



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