Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.H1.01 5.332529
2G.H1.04 5.172527
3G.S2.08 7.3065105
4G.S3.03 6.876676107
5G.S3.04 9.25446
6G.S3.06 10.65445
7G.H2.03 6.765449
8G.H2.04 4.046509
9G.H2.06 7.33571749
10G.H2.07 5.16167649
11G.H2.09 5.9125488
12G.h2s4.01 8.01857749
13G.S4.04 7.7425409
14G.s4h3.04 10.19754178
15G.s4h3.05 8.6454179
16G.H3.01 5.075409
17G.H3.09 7.738509
18G.H3.17 10.986585
19G.H3.18 6.298589
20G.S5.03 3.475428
21G.S5.05 3.886529
22G.HG.04 6.2825409
23G.hgh4.02 7.068336187
24G.hgh4.05 9.145407
25G.H4.05 5.095404
26G.H4.10 12.08754186
27G.H4.12 8.51425
28G.H4.15 5.7325408
29G.H4.16 7.59423
30G.S6.02 5.7025827
31G.S6.05 7.1775404
32G.H5.08 7.796108
33G.H5.13 7.518528
34G.H5.15 2.2675407
35G.H5.17 9.25425
36g.l1x4 7.765438
37g.ctx3 7.482559
38g.ctx5 5.405459
39g.ctx6 4.805656
40g.ctx9 3.9425406
41g.ctx14 6.168569
42g.ctx15 9.2275469
43g.ctx16 5.73875868
441x39 7.815417
451x50 6.7875409
461x52 6.91478
471x56 6.1825478
481x60 6.09407
492x40 6.3625479
502x46 4.306579
512x50 6.8975479
522x56 4.755418
532x57 6.4525408
542x65 2.62405
55E1x50 7.4775818
563x28 8.214516
573x40 4.345418
583x42 6.8785138
593x46 5.5525479
603x50 8.5575479
613x51 8.55508
623x52 8.5745145
633x54 4.835408
64I2x53 10.7465148
65I2x57 9.72254147
664x59 4.0254247
67E2x50 7.9075419
685x47 10.896518
695x58 6.804509
705x62 6.8825406
715x68 7.152527
72I3.L234 5.4725421
73I3.Y235 6.91423
74I3.K237 6.5225403
75I3.R238 8.0475422
76I3.R288 5.9775425
776x44 5.89333619
786x48 8.15818
796x51 7.2125418
806x52 10.73417
817x30 4.55405
827x37 6.985405
837x39 7.36167617
847x42 6.015618
857x49 8.19479
867x52 3.6845158
877x53 6.38579
887x56 9.20254157
898x48 3.4425405
908x50 6.64429779
918x54 7.1075478
92Lig 7.612731110
93b.lhb1x6 6.06453
94b.b1x6 9.245469
95b.l1x3 10.078569
96b.b2x1 8.49167688
97b.b2x5 8.50667607
98b.l3x2 5.045409
99b.b4x4 11.615468
100b.b4x6 11.7067669
101b.l4x2 13.3625464
102b.b5x2 6.29407
103b.b5x3 9.124569
104b.b5x5 5.235495
105b.l5x1 5.662598
106b.l5x5 11.5933649
107b.b6x5 5.06167606
108b.l7x2 5.7575449
109b.b8x4 6.646596
110b.l8x3 2.9175403
111b.b9x3 6.4475496
112b.l9x3 8.874169
113b.l9x6 6.17571748
114b.b10x5 5.838509
115b.l10x1 6.136503
116b.l11x1 4.16449
117b.b12x5 6.025406
118b.b12x6 9.8665168
119b.b13x7 9.3854117
120b.l13x3 9.4825119
121b.l13x6 7.065449
122b.b15x1 7.825119
123b.b15x3 4.29754119
124b.l15x1 5.55447
125b.l15x2 7.06254119
126b.b16x4 8.85116
127b.b16x5 6.685435
128b.b16x6 9.133336118
129b.b17x4 5.675435
130b.b17x5 6.582537
131b.b17x7 9.4125438
132b.l17x3 8.86714739
133b.b18x3 5.8625438
134b.b18x5 5.5725405
135b.l18x1 8.7865196
136b.l18x2 6.37754197
137b.l18x3 7.92405
138b.b19x2 8.11536
139b.l19x2 6.952539
140b.b20x2 6.1625436
141b.b20x4 8.47833638
142b.b20x6 7.69667636
143b.b20x7 5.415409
144b.l20x2 10.5725409
145b.b21x1 9.404537
146b.b21x4 4.615405
147b.b21x5 6.8475404
148b.b21x7 6.464505
149b.l21x5 3.8285124
150b.b22x5 7.034197
151b.l22x5 8.485659
152b.b23x6 6.317147127
153b.l23x1 7.3475486
154b.b24x4 8.9025126
155b.b24x6 6.27254128
156b.l24x2 6.29456
157b.b25x4 2.15404
158b.l25x3 6.54833659
159b.b26x3 4.496296
160b.l26x1 7.29467
161b.l26x5 5.72465
162b.l27x1 12.6071789
163b.l27x2 8.275459
164b.b28x2 7.3575404
165b.b28x3 5.738567
166b.b28x4 9.4325456
167b.b28x5 5.51465
168b.b28x6 8.958559
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.l2x5 b.l4x2 36.295527.78NoYes054
2b.l4x1 b.l4x2 33.95823.82NoYes654
3b.b2x5 b.l4x1 37.81894.94YesNo075
4b.b2x3 b.b2x5 99.26744.65NoYes067
5b.b26x2 b.b2x3 99.51194.86NoNo076
6b.b26x1 b.b26x2 99.75613.44NoNo097
7b.b26x1 b.l27x1 1004.94NoYes099
8G.H3.17 b.l27x1 95.27855.62YesYes859
9G.H3.15 G.H3.17 96.468212.43NoYes885
10G.H2.08 G.H3.15 52.75745.66NoNo888
11G.H2.04 G.H2.08 52.9883.76YesNo098
12G.H2.04 G.H3.08 58.77316.07YesNo099
13G.H3.08 G.S4.04 58.78117.31NoYes099
14G.H3.09 G.S4.04 94.818516.08YesYes099
15G.H3.09 G.S6.01 85.03933.77YesNo095
16G.H4.16 G.S6.01 84.52044.1YesNo035
17G.H4.16 I3.R238 79.221413.96YesYes232
18I3.R238 I3.Y235 79.88448.23YesYes223
19G.h4s6.12 I3.Y235 77.648610.1NoYes043
20G.S6.02 G.h4s6.12 77.54555.61YesNo074
21G.S5.03 G.S6.02 77.40673.63YesYes287
22G.S5.03 G.S5.05 77.26513.77YesYes289
23G.S4.03 G.S5.05 79.32533.77NoYes079
24G.S1.04 G.S4.03 79.19755.71NoNo077
25G.S1.04 G.S3.03 79.06943.65NoYes077
26G.H3.15 G.H3.18 43.88324.83NoYes889
27G.H3.12 G.H3.18 44.1783.77NoYes089
28G.H3.12 G.S1.07 44.07475.71NoNo089
29G.S1.07 G.S4.04 47.36393.65NoYes099
30b.b2x1 b.l27x1 19.8510.61YesYes889
31b.b2x1 b.l3x1 20.41539.02YesNo089
32b.l3x1 b.l5x5 20.504810.95NoYes099
33G.H5.11 G.S3.03 76.17985.24NoYes1087
34G.h2s4.01 b.l5x5 10.804616.04YesYes499
35G.HG.13 G.HG.14 13.1563.56NoNo075
36G.H4.01 G.HG.14 14.18844.89NoNo035
37G.H4.01 G.hgh4.05 14.84993.49NoYes037
38G.HG.15 G.hgh4.02 10.21693.52NoYes077
39G.H3.06 G.hgh4.02 22.42618.38NoYes067
40G.H3.06 G.H4.15 22.82526.22NoYes068
41G.H4.15 G.S4.06 11.27946.55YesNo087
42G.S4.04 G.S4.06 11.43183.93YesNo097
43G.H4.10 G.hgh4.02 10.21628.94YesYes1867
44G.H3.09 G.H4.15 13.34346.43YesYes098
45G.H2.04 G.H2.07 25.05724YesYes099
46G.H2.07 b.l9x6 43.54136.75YesYes498
47b.l11x1 b.l9x6 12.51935.79YesYes498
48b.b14x5 b.b15x1 10.37666.09NoYes059
49b.b10x4 b.b14x5 17.14393.64NoNo065
50b.b10x4 b.b2x4 19.14623.39NoNo066
51b.b2x4 b.b6x5 19.47884.36NoYes066
52b.b3x1 b.b6x5 23.01847.03NoYes056
53b.b3x1 b.l2x3 31.57245.43NoNo058
54b.l2x3 b.l2x5 31.8874.76NoNo085
55G.H2.06 b.l9x6 30.72393.58YesYes498
56G.H2.06 b.l19x1 28.62135.53YesNo099
573x53 G.H5.19 10.20746.25NoNo088
58G.H5.15 G.H5.19 10.45062.83YesNo078
59G.H5.11 G.H5.15 76.17053.07NoYes087
603x54 G.H5.20 65.258.56YesNo089
61G.H5.16 G.H5.20 65.38522.85NoNo069
62G.H5.16 I2x50 65.53461.62NoNo069
63G.H5.15 I2x50 65.68571.62YesNo079
642x43 8x50 15.04276.28NoYes789
653x46 3x50 16.00226.26YesYes799
663x50 G.H5.23 65.341812.54YesNo094
673x54 G.H5.23 67.45043.27YesNo084
683x50 7x53 16.86529.26YesYes799
69b.l17x5 b.l19x1 28.00792.94NoNo069
70b.l17x5 b.l19x2 27.74.42NoYes069
71b.l17x3 b.l19x2 24.18385.04YesYes399
72b.b20x6 b.l17x3 18.10134.53YesYes369
73b.b17x7 b.b20x6 14.294310.72YesYes386
74b.b17x7 b.b21x1 10.13095.97YesYes387
75b.l25x6 b.l27x1 21.611732.99NoYes889
76b.l23x1 b.l25x6 20.935615.48YesNo868
77b.l21x7 b.l23x1 20.27816.22NoYes056
78b.l21x7 b.l23x2 19.94396.22NoNo058
79b.b23x6 b.l23x2 19.26533.45YesNo1278
80b.b23x6 b.b24x6 13.80749.65YesYes1278
81b.b21x7 b.b24x6 13.19875.79YesYes058
82b.l26x5 g.ctx4 43.28526.71YesNo057
83g.ctx3 g.ctx4 43.80193.22YesNo097
84g.ctx3 g.ctx6 14.85069.5YesYes596
85b.l22x5 g.ctx6 10.1734.86YesYes596
86g.ctx3 g.ctx5 28.6744.07YesYes599
87b.lhb1x11 g.ctx5 19.48427.07NoYes549
88b.b4x6 b.b5x3 10.288115.08YesYes699
89b.b1x6 b.b4x6 14.83717.08YesYes699
90b.b1x6 b.b28x5 16.99538.56YesYes695
911x46 1x50 11.65374.39NoYes089
921x50 2x50 14.464512.12YesYes099
932x46 2x50 15.61084.07YesYes799
947x42 Lig 10.77174.98YesYes180
956x48 Lig 21.36273.87YesYes180
966x44 6x48 21.48457.02YesYes198
975x54 6x44 30.17664.87NoYes089
985x54 5x58 30.38274.69NoYes089
993x50 5x58 33.72416.17YesYes099
100b.b28x6 b.lhb1x11 18.46165.82YesNo594
101b.b27x3 b.l25x3 11.8825.48NoYes089
102b.l25x3 b.l27x2 12.49773.78YesYes599
1033x53 I2x57 10.01644.15NoYes087
104b.b2x5 b.l26x1 41.145613.34YesYes077
105b.l26x3 b.l26x5 39.70616.93NoYes675
106b.b5x5 b.l8x8 15.47274.15YesNo954
107b.b8x4 b.l8x8 13.53783.79YesNo964
108b.b11x6 b.l11x1 10.93683.71NoYes099
109b.b11x6 b.l9x3 10.610716.74NoYes099
110b.b28x5 b.b2x5 19.81434.7YesYes057
111b.l26x1 b.l26x3 39.88045.78YesNo677
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x563x325.841YesNo8821
2x567x425.051YesYes8821
2x607x396.181NoYes7722
2x607x426.361NoYes7821
3x327x429.21NoYes8811
3x32Lig11.541NoYes8010
3x334x576.190NoNo7812
3x33Lig7.280NoYes7010
3x366x486.531NoYes7811
3x36Lig13.51NoYes7010
3x406x445.021YesYes8922
3x406x485.871YesYes8821
E2x52Lig5.070NoYes6010
5x395x4310.1724NoNo8721
5x43Lig7.660NoYes7010
5x461Lig4.020NoYes7010
5x476x4410.721YesYes8922
5x476x5220.361YesYes8721
6x446x487.021YesYes9821
6x486x5111.021YesYes8811
6x486x5210.021YesYes8711
6x487x418.441YesNo8712
6x487x4512.431YesNo8912
6x48Lig3.871YesYes8010
6x516x523.221YesYes8711
6x517x343.221YesNo8512
6x51Lig11.391YesYes8010
6x52Lig9.321YesYes7010
6x55Lig5.110NoYes7010
7x387x423.750NoYes6821
7x397x426.751YesYes7821
7x42Lig4.981YesYes8010

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
100.00Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
91.67Single2RH1S-Carazolol2RH1-β2-S-Carazolol
91.67Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
91.67Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
91.67Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
91.67Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
91.67Consensusamine_offonOrthosteric Ligandamine_off amine_on
91.67Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
91.67Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
91.67Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
91.67Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
91.67Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
90.91Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
90.91Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
84.62Single5D5AS-Carazolol5D5A-β2-S-Carazolol
84.62Single5D5BS-Carazolol5D5B-β2-S-Carazolol
84.62Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
84.62Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
84.62Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
84.62Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
84.62Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
83.33Single3NY8ICI118-5513NY8-β2-ICI118-551
83.33Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
83.33Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
83.33Single4GBRS-Carazolol4GBR-β2-S-Carazolol
83.33Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
83.33Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
83.33Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
83.33Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
83.33Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
83.33Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
83.33Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
83.33Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
83.33Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
83.33Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
83.33Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
83.33Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
83.33Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
83.33Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
83.33Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
83.33Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
83.33Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
83.33Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
83.33Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
83.33Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
83.33Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
83.33Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
83.33Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
83.33Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
83.33Single8JJOAlprenolol8JJO-β2-Alprenolol
83.33Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
83.33Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
83.33Single8X64Desloratadine8X64-H1-Desloratadine
83.33Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
83.33Single9PLNN-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLN-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine
83.33Single9PLON-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLO-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine-Go/β1/γ2
83.33Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
83.33Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
83.33Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
83.33Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
83.33Consensusdopamine_offOrthosteric Ligandd2_off d3_off
83.33Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
83.33Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
81.82Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
81.82Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
81.82Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
81.82Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
81.82Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
78.57Single3D4STimolol3D4S-β2-Timolol
78.57Single4AMIBucindolol4AMI-β1-Bucindolol
78.57Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
78.57Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
78.57Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
76.92Single2YCWS-Carazolol2YCW-β1-S-Carazolol
76.92Single5D6LS-Carazolol5D6L-β2-S-Carazolol
76.92Single5X7DS-Carazolol5X7D-β2-S-Carazolol-Cmpd-15
76.92Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
76.92Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
76.92Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
76.92Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
76.92Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
76.92Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
76.92Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
76.92Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
76.92Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
76.92Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single9DYDAsenapine9DYD-5-HT1A-Asenapine-Go/β1/γ2
76.92Single9DYFAsenapine9DYF-5-HT1A-Asenapine-Gi1/β1/γ2
76.92Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
76.92Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
76.92Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
76.92Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
76.92Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
76.92Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
76.92Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
76.92Consensustrace-amine_onOrthosteric Ligandta1_on
75.00Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
75.00Single6A94Zotepine6A94-5-HT2A-Zotepine
75.00Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
75.00Single6PS0S-Carazolol6PS0-β2-S-Carazolol
75.00Single6PS4ICI118-5516PS4-β2-ICI118-551
75.00Single6PS5S-Propranolol6PS5-β2-S-Propranolol
75.00Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
75.00Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
75.00Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
75.00Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
75.00Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
75.00Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
75.00Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
75.00Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
75.00Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
75.00Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
75.00Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
75.00Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
75.00Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
75.00Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
75.00Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
75.00Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
75.00Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
75.00Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
75.00Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
75.00Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
75.00Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
75.00Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
75.00Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
75.00Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
75.00Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
75.00Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
75.00Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
75.00Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
75.00Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
75.00Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
75.00Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
75.00Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
75.00Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
75.00Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
75.00Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
75.00Single9AS3LSD9AS3-5-HT2A-LSD
75.00Single9AS4LSD9AS4-5-HT2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
75.00Single9AS5Mescaline9AS5-5-HT2A-Mescaline
75.00Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
75.00Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
75.00Consensusalpha1_onOrthosteric Ligandalpha1a_on
75.00Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
75.00Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
75.00Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
75.00Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
75.00Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
73.33Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
73.33Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
73.33Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
72.73Single3PBLEticlopride3PBL-D3-Eticlopride
72.73Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
72.73Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
72.73Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
72.73Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
72.73Single9AS2DMT9AS2-5-HT2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
72.73Single9IXJHistamine9IXJ-H2-Histamine-Gs/β1/γ2
72.73Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
71.43Single2YDVNECA2YDV-A2A-NECA
71.43Single4UHRCGS216804UHR-A2A-CGS21680
71.43Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
71.43Single5G53NECA5G53-A2A-NECA-Gs
71.43Single6H7JIsoprenaline6H7J-β1-Isoprenaline
71.43Single6J21Aprepitant6J21-NK1-Aprepitant
71.43Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
71.43Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
71.43Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
71.43Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
71.43Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
71.43Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
71.43Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
71.43Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
71.43Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
71.43Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
71.43Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
71.43Consensustachykinin_offOrthosteric Ligandnk1_off
71.43Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
69.23Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
69.23Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
69.23Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
69.23Single6H7MSalbutamol6H7M-β1-Salbutamol
69.23Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
69.23Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
69.23Single6PS1Timolol6PS1-β2-Timolol
69.23Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
69.23Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
69.23Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
69.23Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
69.23Single7WC7Lisuride7WC7-5-HT2A-Lisuride
69.23Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
69.23Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
69.23Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
69.23Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
69.23Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
69.23Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
69.23Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
69.23Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
69.23Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
69.23Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
69.23Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
69.23Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
69.23Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
69.23Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
69.23Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
69.23Single9CHXS-Carazolol9CHX-β2-S-Carazolol
69.23Single9PQD(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole9PQD-α2a-(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole
69.23Consensusalpha2_onOrthosteric Ligandalpha2b_on
69.23Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
69.23Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
69.23Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
69.23Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
69.23Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
68.75Single3NY9ICI118-5513NY9-β2-ICI118-551
66.67Single4LDEBI1671074LDE-β2-BI167107
66.67Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
66.67Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
66.67Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
66.67Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
66.67Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
66.67Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
66.67Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
66.67Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
66.67Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
66.67Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
66.67Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
66.67Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
66.67Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
66.67Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
66.67Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
66.67Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
66.67Single8JJ8Formoterol8JJ8-β2-Formoterol
66.67Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
66.67Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
66.67Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
66.67Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
66.67Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
66.67Single9LRBHistamine9LRB-H1-Histamine-Gs/β1/γ2
66.67Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
66.67Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
66.67Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
66.67Consensusalpha2_offOrthosteric Ligandalpha2c_off
66.67Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
66.67Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
66.67Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
64.71Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
64.71Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
64.29Single2Y03Isoprenaline2Y03-β1-Isoprenaline
64.29Single5JQHS-Carazolol5JQH-β2-S-Carazolol
64.29Single5WIUNemonapride5WIU-D4-Nemonapride
64.29Single5WIVNemonapride5WIV-D4-Nemonapride-Na
64.29Single6E67BI1671076E67-β2-BI167107-Gs(CT)
64.29Single6PS6Timolol6PS6-β2-Timolol
64.29Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
64.29Single7WC6LSD7WC6-5-HT2A-LSD
64.29Single8ZMFA1L108ZMF-5-HT2C-A1L10
64.29Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
64.29Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
64.29Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
64.29Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
64.29Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
64.29Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
64.29Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
64.29Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
64.29Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
63.64Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
63.64Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
62.50Single6H7LDobutamine6H7L-β1-Dobutamine
62.50Single6IBLArformoterol6IBL-β1-Arformoterol
62.50Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
62.50Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
62.50Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
62.50Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
62.50Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
62.50Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
61.54Single3RZECidoxepin3RZE-H1-Cidoxepin
61.54Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
61.54Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
61.54Single6TPNHTL66416TPN-OX2-HTL6641
61.54Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
61.54Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
61.54Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
61.54Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
61.54Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
61.54Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
61.54Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
61.54Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
61.54Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
61.54Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
61.54Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
61.54Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
61.54Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
61.54Single9ARXSerotonin9ARX-5-HT2A-Serotonin
61.54Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
61.54Single9LRDHistamine9LRD-H1-Histamine-Gi1/β1/γ2
61.54Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
60.00Single3P0GBI1671073P0G-β2-BI167107
60.00Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
60.00Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
60.00Single4U15Tiotropium4U15-M3-Tiotropium
60.00Single5V54Methiothepin5V54-5-HT1B-Methiothepin
60.00Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
60.00Single6J20Aprepitant6J20-NK1-Aprepitant
60.00Single6OL9Tiotropium6OL9-M5-Tiotropium
60.00Single6TQ7SB-3348676TQ7-OX1-SB-334867
60.00Single6WGTLSD6WGT-5-HT2A-LSD
60.00Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
60.00Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
60.00Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
60.00Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
60.00Single9BJKNaloxone9BJK-μ-Naloxone-NAM
60.00Single9I54A1IZV9I54-D1-A1IZV-Gs/β1/γ2
60.00Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
60.00Consensus5ht1_offOrthosteric Ligand5ht1b_off
60.00Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
60.00Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
60.00Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
60.00Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
60.00Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
60.00Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
58.82Single4UG2CGS216804UG2-A2A-CGS21680
58.82Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
58.82Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
58.82Single8X5YAstemizole8X5Y-H1-Astemizole
58.33Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
58.33Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
58.33Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
58.33Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
58.33Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
58.33Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
58.33Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
58.33Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
58.33Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
58.33Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
58.33Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
58.33Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
57.14Single2Y02Carmoterol2Y02-β1-Carmoterol
57.14Single2Y04Salbutamol2Y04-β1-Salbutamol
57.14Single4EJ4Naltrindole4EJ4-δ-Naltrindole
57.14Single4QKX35V4QKX-β2-35V
57.14Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
57.14Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
57.14Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
57.14Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
57.14Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
57.14Single7BU7BI1671077BU7-β1-BI167107
57.14Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
57.14Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
57.14Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
57.14Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
57.14Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
57.14Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
57.14Single8JXRLSD8JXR-D1-LSD
57.14Single8PJKST1718PJK-5-HT1A-ST171-Gi1/β1/γ1
57.14Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
57.14Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
57.14Single8X63Mepyramine8X63-H1-Mepyramine
57.14Single9AS1DMT9AS1-5-HT2A-DMT
57.14Single9JEAAtropine9JEA-M1-Atropine
57.14Consensus5ht5_onOrthosteric Ligand5ht5a_on
57.14Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
57.14Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
57.14Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
57.14Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
57.14Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
57.14Consensushistamine_offOrthosteric Ligandh1_off
56.25Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
56.25Single5CXVTiotropium5CXV-M1-Tiotropium
56.25Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
56.25Single6MXTSalmeterol6MXT-β2-Salmeterol
56.25Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
56.25Single7YITNalfurafine7YIT-κ-Nalfurafine
56.25Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
56.25Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
56.25Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
56.25Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
56.25Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
56.25Consensusalpha1_offOrthosteric Ligandalpha1a_off
56.25Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
56.25Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
56.25Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
56.25Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
56.25Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
56.25Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
56.25Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
56.25Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
55.56Single4IARErgotamine4IAR-5-HT1B-Ergotamine
55.56Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
55.56Single8PKMBefiradol8PKM-5-HT1A-Befiradol-Gi1/β1/γ1
55.56Single8WDTphotoNECA8WDT-A2A-photoNECA
55.56Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
55.56Single9M4TSilodosin9M4T-Alpha1A-Silodosin
55.56Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
54.55Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
54.55Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
54.55Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
54.55Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
54.55Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
54.55Consensussensory_onOrthosteric Ligandopsins_on
53.85Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
53.85Single6B73MP11046B73-κ-MP1104
53.85Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
53.85Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
53.85Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
53.85Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
53.85Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
53.85Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
53.85Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
53.85Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
53.85Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
53.85Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
53.85Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
53.85Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
53.85Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
53.85Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
53.85Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
53.33Single5C1MBU725C1M-μ-BU72
53.33Single5TVNLSD5TVN-5-HT2B-LSD
53.33Single6HLPNetupitant6HLP-NK1-Netupitant
53.33Single7C61Ergotamine7C61-5-HT1B-Ergotamine
53.33Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
53.33Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
53.33Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
53.33Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
53.33Single9F33FOB02-04A9F33-D3-FOB02-04A-Go/β1/γ2
53.33Single9F34FOB02-04A9F34-D3-FOB02-04A-Go/β1/γ2
53.33Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
53.33Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
53.33Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
53.33Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
52.94Single5X93K-87945X93-ETB-K-8794
52.94Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
52.94Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
52.94Single7UM4AS26747237UM4-5-HT5A-AS2674723
52.94Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
52.94Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
52.94Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
52.94Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
52.94Single9AS02-bromo-LSD9AS0-5-HT2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
52.94Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
52.94Single9DYEBuspirone9DYE-5-HT1A-Buspirone-Go/β1/γ2
52.94Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
52.94Consensusendothelin_offOrthosteric Ligandetb_off
52.94Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
52.63Single6HLOAprepitant6HLO-NK1-Aprepitant
50.00Single2YDOAdenosine2YDO-A2A-Adenosine
50.00Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
50.00Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
50.00Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
50.00Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
50.00Single6E59L-7607356E59-NK1-L-760735
50.00Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
50.00Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
50.00Single6KUXRS-799486KUX-α2a-RS-79948
50.00Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
50.00Single6PT3DPI-2876PT3-δ-DPI-287
50.00Single6TPGEMPA6TPG-OX2-EMPA
50.00Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
50.00Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
50.00Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
50.00Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
50.00Single7T94Acetylcholine7T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
50.00Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
50.00Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
50.00Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
50.00Single7UL3Famotidine7UL3-H2-Famotidine
50.00Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
50.00Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
50.00Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
50.00Single8E0GBU728E0G-μ-BU72
50.00Single8EA0Iperoxo8EA0-M3-Iperoxo
50.00Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
50.00Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
50.00Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
50.00Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
50.00Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
50.00Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
50.00Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
50.00Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
50.00Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
50.00Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
50.00Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single8XVLZibotentan8XVL-ETA-Zibotentan
50.00Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
50.00Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
50.00Single9AS9RS130-1809AS9-5-HT2A-RS130-180
50.00Single9ASARS130-1809ASA-5-HT2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
50.00Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
50.00Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
50.00Consensusa2_onOrthosteric Liganda2b_on
50.00Consensusa2_on_gpOrthosteric Liganda2b_on_gp
50.00Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
50.00Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
50.00Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
50.00Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
50.00Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
50.00Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
50.00Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
50.00Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
50.00Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
47.37Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
47.37Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
47.37Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
47.37Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
47.06Single4RWADIPP-NH24RWA-δ-DIPP-NH2
47.06Single6CM4Risperidone6CM4-D2-Risperidone
47.06Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
47.06Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
47.06Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
47.06Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
47.06Single8JJLOlodaterol8JJL-β2-Olodaterol
47.06Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
47.06Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
47.06Single9GL2Befiradol9GL2-5-HT1A-Befiradol-Gs/β1/γ2
46.67Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
46.67Single2Y01Dobutamine2Y01-β1-Dobutamine
46.67Single4DAJTiotropium4DAJ-M3-Tiotropium
46.67Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
46.67Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
46.67Single4MQSIperoxo4MQS-M2-Iperoxo
46.67Single4U14Tiotropium4U14-M3-Tiotropium
46.67Single5DHGC-355DHG-NOP-C-35
46.67Single5DSGTiotropium5DSG-M4-Tiotropium
46.67Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
46.67Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
46.67Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
46.67Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
46.67Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
46.67Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
46.67Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
46.67Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
46.67Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
46.67Single7UL4Alvimopan7UL4-μ-Alvimopan
46.67Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
46.67Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
46.67Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
46.67Single8T1WCVN4248T1W-GPR6-CVN424
46.67Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
46.67Single8YN8Proxyfan8YN8-H3-Proxyfan-Go/β1/γ2
46.67Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
46.67Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
46.67Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
46.67Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
46.67Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
46.67Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
46.15Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
46.15Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
46.15Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
46.15Single6HLLCP999946HLL-NK1-CP99994
46.15Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
46.15Single7SRQLSD7SRQ-5-HT2B-LSD
46.15Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
46.15Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
46.15Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
46.15Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
46.15Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
46.15Single8YN7Immethridine8YN7-H3-Immethridine-Go/β1/γ2
46.15Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
46.15Single9AS7Psilocin9AS7-5-HT2A-Psilocin
45.45Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
45.45Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
45.00Single3QAKUK-4320973QAK-A2A-UK-432097
44.44Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
44.44Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
44.44Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
44.44Single7EZCUKA7EZC-A2A-UKA
44.44Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
44.44Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
44.44Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
44.44Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
44.44Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
43.75Single2Y00Dobutamine2Y00-β1-Dobutamine
43.75Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
43.75Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
43.75Single5WQCEMPA5WQC-OX2-EMPA
43.75Single5XPRBosentan5XPR-ETB-Bosentan
43.75Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
43.75Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
43.75Single6LUQHaloperidol6LUQ-D2-Haloperidol
43.75Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
43.75Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
43.75Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
43.75Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
43.75Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
43.75Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
43.75Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
43.75Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
43.75Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
43.75Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
43.75Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
43.75Single8JXSPF-61428JXS-D1-PF-6142
43.75Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
43.75Single9ARZ2-bromo-LSD9ARZ-5-HT2A-2-bromo-LSD
43.75Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
43.75Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
43.75Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
42.86Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
42.86Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
42.86Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
42.86Single5WF5UK-4320975WF5-A2A-UK-432097
42.86Single6AKXA4R6AKX-CCR5-A4R
42.86Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
42.86Single6ME2Ramelteon6ME2-MT1-Ramelteon
42.86Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
42.86Single6PT2KGCHM076PT2-δ-KGCHM07
42.86Single6TODEMPA6TOD-OX1-EMPA-Na
42.86Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
42.86Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
42.86Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
42.86Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
42.86Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
42.86Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
42.86Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
42.86Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
42.86Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
42.86Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
42.86Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
42.86Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
42.86Single8IWESpermidine8IWE-TA9-Spermidine
42.86Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
42.86Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ2
42.86Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
42.86Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
42.86Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
42.86Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
42.86Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
42.86Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
42.86Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
42.86Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
42.86Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
42.86Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
42.86Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
42.11Single5WF6UK-4320975WF6-A2A-UK-432097
42.11Single7SK9CCX6627SK9-ACKR3-CCX662
42.11Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
42.11Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
42.11Single9MD1Buspirone9MD1-5-HT1A-Buspirone-Gz/β1/γ2
41.67Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
41.67Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
41.67Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
41.67Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
41.67Single9CHUNoradrenaline9CHU-β2-Noradrenaline
41.18Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
41.18Single4DJHJDTic4DJH-κ-JDTic
41.18Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
41.18Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
41.18Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
41.18Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
41.18Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
41.18Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
41.18Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
41.18Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
41.18Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
41.18Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
41.18Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
41.18Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
41.18Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
41.18Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
41.18Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
41.18Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
41.18Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
41.18Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
40.00Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
40.00Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
40.00Single4MBSMaraviroc4MBS-CCR5-Maraviroc
40.00Single4ZJCSB-6740424ZJC-OX1-SB-674042
40.00Single6IQLL7458706IQL-D4-L745870
40.00Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
40.00Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
40.00Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
40.00Single6VI4JDTic6VI4-κ-JDTic
40.00Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
40.00Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
40.00Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
40.00Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
40.00Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
40.00Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
40.00Single8RLNLUF58348RLN-A2A-LUF5834
40.00Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
40.00Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
40.00Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
40.00Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
40.00Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
40.00Consensusopsins_offOrthosteric Ligandrhodopsin_off
40.00Consensussensory_offOrthosteric Ligandopsins_off
38.89Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
38.89Single6A93Risperidone6A93-5-HT2A-Risperidone
38.89Single6ZG4HTL00099366ZG4-M1-HTL0009936
38.89Single7DFPSpiperone7DFP-D2-Spiperone
38.89Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
38.89Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
38.89Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
38.89Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
38.89Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
38.89Single8JWY2-1188JWY-A2A-2-118
38.89Single8JWZAB9288JWZ-A2A-AB928-Na
38.89Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
38.89Single9M4QDoxazosin9M4Q-Alpha1A-Doxazosin
38.89Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
38.89Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
38.89Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
38.89Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
38.46Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
38.46Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
38.46Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
38.46Single3UZAGTPL92363UZA-A2A-GTPL9236
38.46Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
38.46Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
38.46Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
38.46Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
38.46Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
38.46Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.46Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
38.46Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
38.46Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
38.46Single9LRCHistamine9LRC-H4-Histamine
38.46Single9LREHistamine9LRE-H4-Histamine-Gi1/β1/γ2
38.46Consensus5ht2_onOrthosteric Ligand5ht2b_on
38.46Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
38.46Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
38.46Consensusgi_sensoryOrthosteric Ligandgi_opsins
38.46Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
38.46Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
38.46Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
38.46Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
38.10Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
37.50Single5DHHSB-6121115DHH-NOP-SB-612111
37.50Single6TOTLemborexant6TOT-OX1-Lemborexant
37.50Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
37.50Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
37.50Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
37.50Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
37.50Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
37.50Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
37.50Single8CU6LJ-45178CU6-A2A-LJ-4517
37.50Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
37.50Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
37.50Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
37.50Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
37.50Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
37.50Single9KFJPubChem 1383196749KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
37.50Consensusa3_onOrthosteric Liganda3a_on
37.50Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
36.84Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
36.84Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
36.84Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
36.84Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
36.84Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
36.84Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
36.84Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
36.84Single8XVJMacitentan8XVJ-ETA-Macitentan
36.84Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
36.84Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
36.84Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
36.36Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
36.36Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
36.36Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
36.36Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
36.00Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
36.00Single9KDFRES-701-39KDF-ETB-RES-701-3
35.71Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
35.71Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
35.71Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
35.71Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
35.71Single6TP4ACT-4622066TP4-OX1-ACT-462206
35.71Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
35.71Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
35.71Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
35.71Single7V68Iperoxo7V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
35.71Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
35.71Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
35.71Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
35.71Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
35.71Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
35.71Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
35.29Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
35.29Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
35.29Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
35.29Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
35.29Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
35.29Single6TP6Filorexant6TP6-OX1-Filorexant
35.29Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
35.29Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
35.29Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
35.29Single7SINNPS-21437SIN-CaS-NPS-2143
35.29Single7SINNPS-21437SIN-CaS-NPS-2143
35.29Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
35.29Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
35.29Single7W41PD1762527W41-BB2-PD176252
35.29Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
35.29Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
35.29Single8QOTNanobody-E8QOT-μ-Nanobody-E
35.29Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
35.29Single8XYKVUF106618XYK-CXCR3-VUF10661-Go/β1/γ2
35.29Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
35.29Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
35.29Single9HAPTolvaptan9HAP-V2-Tolvaptan
35.29Consensusa3_on_gpOrthosteric Liganda3a_on_gp
35.29Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
35.29Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
35.29Consensusadenosine_offOrthosteric Liganda1_off a2_off
35.29Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
35.29Consensusbombesin_offOrthosteric Ligandbb2_off
35.29Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
35.29Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
35.00Single5ZTYAM102575ZTY-CB2-AM10257
35.00Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
35.00Single7XN9L-054,5227XN9-SST2-L-054,522
35.00Single9M0RNeuropeptide VF9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
35.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
35.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
35.00Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
35.00Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
35.00Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
35.00Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
35.00Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
34.78Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
34.78Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
34.78Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
34.78Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
33.33Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
33.33Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
33.33Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
33.33Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
33.33Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
33.33Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
33.33Single5WS3EMPA5WS3-OX2-EMPA
33.33Single6AKYMaraviroc6AKY-CCR5-Maraviroc
33.33Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
33.33Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
33.33Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
33.33Single7B6WCyclazosin7B6W-α1b-Cyclazosin
33.33Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
33.33Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
33.33Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
33.33Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
33.33Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
33.33Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
33.33Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
33.33Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
33.33Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
33.33Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
33.33Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
33.33Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
33.33Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
33.33Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
33.33Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
33.33Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
33.33Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
33.33Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
33.33Single8Y0HVUF114188Y0H-CXCR3-VUF11418
33.33Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go/β1/γ2
33.33Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
33.33Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
33.33Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
33.33Single9H2XA1IR19H2X-A2A-A1IR1-Na
33.33Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
33.33Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
33.33Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
33.33Consensusbombesin_onOrthosteric Ligandbb2_on
33.33Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
33.33Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
33.33Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
33.33Consensusorexin_offOrthosteric Ligandox2_off ox1_off
33.33Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
33.33Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
32.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
31.82Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
31.82Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
31.82Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
31.58Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
31.58Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
31.58Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
31.58Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
31.58Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
31.58Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
31.58Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
31.58Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
31.58Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
31.58Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
31.58Single8XYIVUF106618XYI-CXCR3-VUF10661
31.58Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
31.58Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
31.58Consensuslpa_offOrthosteric Ligandlpa1_off
31.58Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
31.58Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
31.58Consensusorexin_onOrthosteric Ligandox2_on
31.58Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
31.58Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
31.25Single5IU7Q274563465IU7-A2A-Q27456346-Na
31.25Single5JTBZM-2413855JTB-A2A-ZM-241385
31.25Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
31.25Single5UVIZM-2413855UVI-A2A-ZM-241385
31.25Single6AQFZM-2413856AQF-A2A-ZM-241385
31.25Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
31.25Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
31.25Single6TPKRetosiban6TPK-OT-Retosiban
31.25Single6V9SGTPL114036V9S-OX1-GTPL11403
31.25Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
31.25Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
31.25Single7T32ZM-2413857T32-A2A-ZM-241385
31.25Single7VODCariprazine7VOD-5-HT2A-Cariprazine
31.25Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
31.25Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
31.25Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
31.25Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
31.25Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
31.25Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
31.25Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.25Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
31.25Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Consensusa2_offOrthosteric Liganda2a_off
31.25Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
31.25Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
31.25Consensusvasop-oxy_offOrthosteric Ligandot_off
30.77Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
30.77Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
30.77Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
30.77Single9EE9Adenosine9EE9-A2A-Adenosine-Gs/β1/γ2
30.77Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
30.43Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
30.43Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.43Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
30.43Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
30.43Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
30.43Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
30.00Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
30.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
30.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
30.00Single6K1QIRL25006K1Q-ETB-IRL2500
30.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
30.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
30.00Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
30.00Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
30.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
30.00Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
30.00Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
30.00Single9M54Neuropeptide VF9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
30.00Consensuschemerin_onOrthosteric Ligandcml1_on
30.00Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
30.00Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
29.63Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
29.41Single3EMLZM-2413853EML-A2A-ZM-241385
29.41Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
29.41Single5IU8Q274563475IU8-A2A-Q27456347-Na
29.41Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
29.41Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
29.41Single5UIGCmpd-15UIG-A2A-Cmpd-1
29.41Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
29.41Single6DRXLisuride6DRX-5-HT2B-Lisuride
29.41Single6S0LZM-2413856S0L-A2A-ZM-241385
29.41Single7PYRPSB-21157PYR-A2A-PSB-2115
29.41Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
29.41Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
29.41Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
29.41Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
29.41Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
29.41Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
29.41Single9H37A1IR09H37-A2A-A1IR0-Na
29.41Single9JGKBalovaptan9JGK-5-HT2B-Balovaptan
29.41Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
29.41Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
29.41Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
29.41Consensusblt_onOrthosteric Ligandblt1_on
29.41Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
29.41Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
29.41Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
29.41Consensusleukotriene_onOrthosteric Ligandblt_on
29.41Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
29.17Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
29.17Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
29.17Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
29.17Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
29.17Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
29.17Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
29.17Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
29.17Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
29.17Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
29.17Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
29.17Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
29.17Consensusvasop-oxy_onOrthosteric Ligandv2_on
29.17Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
28.57Single6ME5Agomelatine6ME5-MT1-Agomelatine
28.57Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
28.57Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
28.57Single7WC5Psilocin7WC5-5-HT2A-Psilocin
28.57Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
28.57Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
28.57Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
28.57Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
28.57Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
28.57Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
28.57Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
28.57Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
28.57Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
28.57Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
28.57Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
28.57Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
28.57Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
28.57Single9JF4PD1683689JF4-BB1-PD168368
28.57Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
28.57Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
28.57Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
28.57Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
28.57Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
28.00Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
28.00Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
28.00Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
27.78Single5CGCHTL142425CGC-mGlu5-HTL14242
27.78Single5IUAQ274563485IUA-A2A-Q27456348-Na
27.78Single5N2RPSB-365N2R-A2A-PSB-36-Na
27.78Single5N2SPSB365N2S-A1-PSB36
27.78Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
27.78Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
27.78Single6S0QZM-2413856S0Q-A2A-ZM-241385
27.78Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
27.78Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
27.78Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
27.78Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
27.78Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
27.78Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
27.78Single8GNEKW-63568GNE-A2A-KW-6356-Na
27.78Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
27.78Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
27.78Single8S4DCMF-0198S4D-Apelin-CMF-019
27.78Single8TF5Oleic acid8TF5-GPR6-Oleic acid
27.78Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
27.78Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
27.78Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
27.78Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
27.78Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
27.78Single9EHSLUF76029EHS-A3A-LUF7602
27.78Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
27.78Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
27.78Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
27.78Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
27.27Single7F8XNN90567F8X-CCKA-NN9056
27.27Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
27.27Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
27.27Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
27.27Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
27.27Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
27.27Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.27Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
27.27Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
27.27Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
27.27Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
27.27Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
27.27Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
26.92Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
26.92Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
26.92Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
26.67Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
26.67Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
26.67Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
26.67Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
26.67Single8K5BNiacin8K5B-HCA2-Niacin
26.67Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
26.67Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
26.32Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
26.32Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
26.32Single7PX4PSB-21137PX4-A2A-PSB-2113
26.32Single7TUYGSK682753A7TUY-GPR183-GSK682753A
26.32Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
26.32Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
26.32Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
26.32Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
26.32Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
26.32Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
26.32Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
26.32Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
26.32Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
26.32Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
26.32Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
26.32Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
26.32Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
26.32Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
26.32Single8ZWFJR14a8ZWF-C3aB-JR14a
26.32Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
26.32Single9IK9SST analogue9IK9-SST1-SST analogue-Gi1/β1/γ2
26.32Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
26.32Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
26.32Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
26.32Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
26.09Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
26.09Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
26.09Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
26.09Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
26.09Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
26.09Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
26.09Single9IK8SST analogue9IK8-SST1-SST analogue-Gi1/β1/γ2
26.09Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
26.09Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
26.09Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
25.93Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
25.93Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
25.93Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
25.93Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
25.00Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
25.00Single4S0VSuvorexant4S0V-OX2-Suvorexant
25.00Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
25.00Single5MZPCaffeine5MZP-A2A-Caffeine-Na
25.00Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
25.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
25.00Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
25.00Single6DS0Ly2660976DS0-5-HT2B-Ly266097
25.00Single6IGLIRL16206IGL-ETB-IRL1620
25.00Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
25.00Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
25.00Single6ME9Ramelteon6ME9-MT2-Ramelteon
25.00Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
25.00Single6TPJSuvorexant6TPJ-OX2-Suvorexant
25.00Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
25.00Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
25.00Single7F8ULintitript7F8U-CCKA-Lintitript
25.00Single7K15MKD0467K15-BLT1-MKD046-Na
25.00Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
25.00Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
25.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
25.00Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
25.00Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
25.00Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
25.00Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
25.00Single7XRRLemborexant7XRR-OX2-Lemborexant
25.00Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
25.00Single8GNGIstradefylline8GNG-A2A-Istradefylline
25.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
25.00Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
25.00Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
25.00Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
25.00Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
25.00Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
25.00Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
25.00Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
25.00Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
25.00Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
25.00Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.00Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
25.00Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
25.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
25.00Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
25.00Single9K6LSA09K6L-TAS2R16-SA0-Gi2/β1/γ2
25.00Single9KPESA09KPE-TAS2R16-SA0-Gi1/β1/γ2
25.00Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
25.00Consensusangiotensin_offOrthosteric Ligandat1_off
25.00Consensusangiotensin_onOrthosteric Ligandat1_on
25.00Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
25.00Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
25.00Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
25.00Consensusbradykinin_onOrthosteric Ligandbk2_on
25.00Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
25.00Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
25.00Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
25.00Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
25.00Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
25.00Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
25.00Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
25.00Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
25.00Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
25.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
25.00Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
25.00Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
25.00Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
25.00Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
24.14Single5GLHEndothelin-15GLH-ETB-Endothelin-1
24.14Single6IGKEndothelin-36IGK-ETB-Endothelin-3
24.14Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
24.00Single6JODAngiotensin II6JOD-AT2-Angiotensin II
24.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
24.00Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
24.00Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
24.00Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
24.00Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
24.00Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
24.00Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
24.00Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
24.00Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
24.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
24.00Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
23.81Single5CGDHTL142425CGD-mGlu5-HTL14242
23.81Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
23.81Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
23.81Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
23.81Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
23.81Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
23.81Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
23.81Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
23.81Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
23.81Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
23.81Consensuscck_onOrthosteric Ligandccka_on cckb_on
23.81Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
23.81Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
23.81Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
23.81Consensusprostanoid_offOrthosteric Ligandep_off dp_off
23.53Single3REYXAC3REY-A2A-XAC
23.53Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
23.53Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
23.53Single5IUBQ274563445IUB-A2A-Q27456344-Na
23.53Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
23.53Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
23.53Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
23.53Single6FFIMMPEP6FFI-mGlu5-MMPEP
23.53Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
23.53Single6MH8ZM-2413856MH8-A2A-ZM-241385
23.53Single6TP3Nemorexant6TP3-OX1-Nemorexant
23.53Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
23.53Single6ZG9GSK10347026ZG9-M1-GSK1034702
23.53Single7AROLUF58337ARO-A2A-LUF5833-Na
23.53Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
23.53Single7F61PF-036547467F61-H3-PF-03654746
23.53Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
23.53Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
23.53Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
23.53Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
23.53Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
23.53Single8K5CAcipimox8K5C-HCA2-Acipimox
23.53Single8K9LDamgo8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
23.53Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
23.53Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
23.53Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
23.53Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
23.53Single9JH3CMF-0199JH3-Apelin-CMF-019-Gi1/β1/γ2
23.53Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
23.53Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
23.53Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
23.53Consensushca_onOrthosteric Ligandhca2_on
23.33Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
23.33Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
23.08Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
23.08Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
23.08Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
23.08Single7WC4Serotonin7WC4-5-HT2A-Serotonin
23.08Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
23.08Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
23.08Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.08Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
23.08Single8PWNTheophylline8PWN-A2A-Theophylline
23.08Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
23.08Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
23.08Single8ZRTET-18ZRT-ETB-ET-1
23.08Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
23.08Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
22.73Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
22.73Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
22.73Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
22.73Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
22.73Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
22.73Single9IPYJR14a9IPY-C3aB-JR14a
22.73Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
22.73Consensuskisspeptin_onOrthosteric Ligandkiss1_on
22.58Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
22.58Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
22.22Single4YAYZD-71554YAY-AT1-ZD-7155
22.22Single5TGZAM65385TGZ-CB1-AM6538
22.22Single5UENDU1725UEN-A1-DU172
22.22Single6FFHFenobam6FFH-mGlu5-Fenobam
22.22Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
22.22Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
22.22Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
22.22Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
22.22Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
22.22Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
22.22Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
22.22Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
22.22Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
22.22Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
22.22Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
22.22Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
22.22Single8K5DGSK2560738K5D-HCA2-GSK256073
22.22Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
22.22Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
22.22Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
22.22Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
22.22Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
22.22Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
22.22Single9IYAONO-97105319IYA-GPR55-ONO-9710531
22.22Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
22.22Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
22.22Consensuscck_offOrthosteric Ligandccka_off
22.22Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
22.22Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
22.22Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
22.22Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
22.22Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
22.22Consensushca_on_gpOrthosteric Ligandhca2_on_gp
22.22Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
22.22Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
22.22Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
22.22Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
22.22Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
21.74Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
21.74Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
21.74Single7QA8Peptide7QA8-STE2-Peptide
21.74Single7QA8Peptide7QA8-STE2-Peptide
21.74Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
21.74Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
21.74Single8IEBA1LYA8IEB-GPR156-A1LYA
21.74Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
21.74Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
21.74Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
21.74Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
21.74Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
21.74Consensuslpl_onOrthosteric Ligands1p_on lpa_on
21.74Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
21.43Single3RFMCaffeine3RFM-A2A-Caffeine
21.43Single6TQ9SB-4081246TQ9-OX1-SB-408124
21.43Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
21.43Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
21.43Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
21.43Single8A2OTheophylline8A2O-A2A-Theophylline-Na
21.43Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
21.43Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
21.43Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
21.43Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
21.05Single4NTJAZD12834NTJ-P2Y12-AZD1283
21.05Single6D26Fevipiprant6D26-DP2-Fevipiprant
21.05Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
21.05Single7C4SS1P7C4S-S1P3-S1P
21.05Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
21.05Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
21.05Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
21.05Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
21.05Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
21.05Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
21.05Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
21.05Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
21.05Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
21.05Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
21.05Single9HC04YI9HC0-mGlu5-4YI
21.05Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
21.05Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
21.05Consensusblt_offOrthosteric Ligandblt1_off
21.05Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
21.05Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
21.05Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
21.05Consensusdp_offOrthosteric Liganddp2_off
21.05Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
20.83Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
20.83Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
20.83Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
20.83Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
20.83Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
20.83Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
20.69Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
20.69Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
20.69Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
20.69Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
20.69Single8IY6Endothelin-18IY6-ETB-Endothelin-1
20.69Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
20.69Consensusendothelin_onOrthosteric Ligandetb_on eta_on
20.00Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
20.00Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
20.00Single5XR8AM8415XR8-CB1-AM841
20.00Single5XRAAM115425XRA-CB1-AM11542
20.00Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
20.00Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
20.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
20.00Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
20.00Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
20.00Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
20.00Single7FEECP559407FEE-CB1-CP55940-ZCZ011
20.00Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
20.00Single7P2L4YI7P2L-mGlu5-4YI
20.00Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
20.00Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
20.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
20.00Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
20.00Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
20.00Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
20.00Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
20.00Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
20.00Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
20.00Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
20.00Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
20.00Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
20.00Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
20.00Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
20.00Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
20.00Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
20.00Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
20.00Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
20.00Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
20.00Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
20.00Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
20.00Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
20.00Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
20.00Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
20.00Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
20.00Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
19.35Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
19.23Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
19.23Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
19.23Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
19.23Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
19.23Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
19.23Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.23Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
19.23Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
19.05Single4N4WSANT-14N4W-SMO-SANT-1
19.05Single6KQICP559406KQI-CB1-CP55940-Org27569
19.05Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
19.05Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
19.05Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
19.05Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
19.05Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
19.05Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
19.05Single8XJNCloprosetnol8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single9DGIZ85267113509DGI-CB1-Z8526711350
19.05Single9GGGI-BOP9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.05Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
19.05Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
19.05Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
19.05Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
19.05Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
19.05Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
19.05Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
19.05Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
18.75Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
18.75Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
18.75Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
18.75Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
18.75Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
18.75Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
18.75Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
18.75Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
18.75Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
18.75Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.75Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
18.75Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
18.75Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
18.75Single9IZDCHBA9IZD-HCA1-CHBA-Gi1/β1/γ2
18.75Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
18.52Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
18.52Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
18.52Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
18.52Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
18.52Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
18.52Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
18.52Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
18.52Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
18.52Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
18.52Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
18.18Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
18.18Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
18.18Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
18.18Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
18.18Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
18.18Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
18.18Single8XJOU466198XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
18.18Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
18.18Single9GG5U466199GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
18.18Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
18.18Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
18.18Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
18.18Consensustp_onOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Consensustp_on_gpOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
17.86Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
17.86Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
17.86Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
17.65Single3PWHZM-2413853PWH-A2A-ZM-241385
17.65Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
17.65Single7BR3Elagolix7BR3-GnRH1-Elagolix
17.65Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
17.65Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
17.65Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
17.65Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
17.65Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
17.65Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.65Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
17.65Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
17.65Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
17.65Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
17.65Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
17.65Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
17.65Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
17.65Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
17.39Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
17.39Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
17.39Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single8QJ2pN1628QJ2-MC4-pN162-Gs
17.39Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
17.39Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
17.39Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
17.39Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
17.39Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
17.39Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
17.24Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
17.24Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
17.24Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
17.24Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
17.24Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
17.24Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
17.24Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
17.24Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
17.24Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
16.67Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
16.67Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
16.67Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
16.67Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
16.67Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
16.67Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
16.67Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
16.67Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
16.67Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
16.67Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
16.67Single8IEIA1LYA8IEI-GPR156-A1LYA
16.67Single8IEIA1LYA8IEI-GPR156-A1LYA
16.67Single8IEPA1LYA8IEP-GPR156-A1LYA
16.67Single8IEPA1LYA8IEP-GPR156-A1LYA
16.67Single8IHKAcifran8IHK-HCA3-Acifran
16.67Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
16.67Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
16.67Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
16.67Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single8WKYPG-9348WKY-MC4-PG-934
16.67Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
16.67Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
16.67Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
16.67Single9KPDSA09KPD-TAS2R16-SA0-chim(Gs-CtGt3)/β1/γ2
16.67Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
16.67Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
16.67Consensusgrh_offOrthosteric Ligandgnrh1_off
16.67Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
16.67Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
16.13Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
16.13Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
16.13Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
16.00Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
16.00Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
16.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
16.00Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
16.00Single8IEBA1LYA8IEB-GPR156-A1LYA
16.00Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
16.00Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
16.00Single9E82SDF-1-beta9E82-ACKR3-SDF-1-β-Arrestin2
16.00Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
16.00Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
16.00Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
16.00Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
16.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
16.00Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
16.00Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
16.00Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
15.79Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
15.79Single6D27CAY104716D27-DP2-CAY10471
15.79Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
15.79Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
15.79Single6GPSMK08126GPS-CCR2-MK0812
15.79Single6IIVDaltroban6IIV-TXA2-Daltroban
15.79Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
15.79Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
15.79Single7F83PF-051904577F83-Ghrelin-PF-05190457
15.79Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
15.79Single7V3ZCP559407V3Z-CB1-CP55940
15.79Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
15.79Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
15.79Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
15.79Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
15.79Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
15.79Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
15.79Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
15.79Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
15.62Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
15.62Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
15.62Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
15.62Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
15.38Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
15.38Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
15.38Single6W25SHU91196W25-MC4-SHU9119-Ca
15.38Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
15.38Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.38Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
15.38Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
15.38Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
15.38Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
15.38Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
15.38Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
15.38Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
15.15Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
15.00Single6GPXMK08126GPX-CCR2-MK0812
15.00Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
15.00Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
15.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
15.00Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
15.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
15.00Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
15.00Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
15.00Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
15.00Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
15.00Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
15.00Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
15.00Single8ZVZBW245C8ZVZ-DP1-BW245C-Gs/β1/γ2
15.00Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
15.00Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
15.00Single9KPFSA09KPF-TAS2R16-SA0-Gi1/β1/γ2
15.00Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
15.00Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
15.00Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
15.00Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
15.00Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
15.00Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
15.00Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
14.81Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
14.81Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
14.81Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
14.81Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
14.81Single9BLCCagrilintide backbone (non-acylated)9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
14.81Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
14.81Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
14.81Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
14.81Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
14.71Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
14.29Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
14.29Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
14.29Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
14.29Single7R0CAVP7R0C-V2-AVP-Arrestin2
14.29Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
14.29Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
14.29Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
14.29Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
14.29Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
14.29Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
14.29Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
14.29Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
14.29Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
14.29Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
14.29Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
14.29Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
14.29Single9CLWTUG-13759CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Single9EGOYVF9EGO-CB1-YVF-Gi1/β1/γ2
14.29Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
14.29Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
14.29Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
14.29Consensuslpa_onOrthosteric Ligandlpa1_on
14.29Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
14.29Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
14.29Consensuspth_onOrthosteric Ligandpth1_on pth2_on
14.29Consensusrelaxin_onOrthosteric Ligandrxfp4_on
14.29Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
14.29Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
13.89Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
13.89Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
13.79Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
13.79Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
13.79Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
13.79Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
13.79Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
13.79Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
13.79Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
13.64Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
13.64Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
13.64Single5X33BIIL2605X33-BLT1-BIIL260
13.64Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
13.64Single6IIURamatroban6IIU-TXA2-Ramatroban
13.64Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
13.64Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
13.64Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
13.64Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
13.64Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
13.64Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
13.64Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
13.64Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.64Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
13.64Single9AU0BW245C9AU0-DP1-BW245C-Gs/β1/γ2
13.64Single9CM3TUG-13759CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.51Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
13.51Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
13.51Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
13.33Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
13.33Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
13.33Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
13.33Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
13.33Single8Y02Retinal8Y02-OPN1SW-Retinal-Gi1/β1/γ2
13.33Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
13.33Consensusglp_onOrthosteric Ligandglp1_on glp2_on
13.33Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
13.16Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
13.04Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
13.04Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
13.04Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
13.04Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
13.04Single9M1HProstaglandin E29M1H-EP1-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
13.04Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
12.90Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
12.90Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
12.90Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
12.90Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
12.90Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
12.90Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
12.90Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
12.90Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
12.90Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
12.90Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
12.90Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
12.90Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
12.82Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
12.82Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
12.50Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
12.50Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
12.50Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
12.50Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
12.50Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
12.50Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
12.50Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
12.50Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
12.50Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
12.50Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
12.50Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
12.50Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
12.50Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
12.50Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
12.50Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
12.50Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
12.50Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
12.50Single9NS9TUG-13759NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
12.20Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
12.12Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
12.12Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
12.12Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
12.00Single4XT1Fractalkine4XT1-US28-Fractalkine
12.00Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
12.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
12.00Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
12.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
12.00Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
12.00Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
12.00Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
12.00Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
12.00Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
12.00Consensussomatostatin_offOrthosteric Ligandsst2_off
11.90Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
11.76Single3OE9IT1t3OE9-CXCR4-IT1t
11.76Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
11.76Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
11.76Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
11.76Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
11.76Single8YKDDehydroepiandrosterone8YKD-ADGRG2-Dehydroepiandrosterone-chim(NtGi1-Gs)/β1/γ2
11.76Single9B9Y7DY9B9Y-CB1-7DY
11.76Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
11.76Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
11.54Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
11.54Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
11.54Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
11.54Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
11.54Single7XNACYN1548067XNA-SST2-CYN154806
11.54Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
11.54Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
11.54Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
11.54Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
11.54Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
11.54Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
11.54Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
11.54Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
11.54Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
11.54Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
11.43Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
11.43Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
11.43Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
11.43Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
11.11Single3OE0CVX153OE0-CXCR4-CVX15
11.11Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
11.11Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
11.11Single7F8YDevazepide7F8Y-CCKA-Devazepide
11.11Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
11.11Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
11.11Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
11.11Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
11.11Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
11.11Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
11.11Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
11.11Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
11.11Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
11.11Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
11.11Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
11.11Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
10.71Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
10.71Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
10.71Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
10.71Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
10.71Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
10.71Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
10.71Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
10.71Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
10.71Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
10.71Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
10.71Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
10.71Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
10.71Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
10.71Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
10.53Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
10.53Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
10.53Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
10.53Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
10.53Single8ZPMAMD0708ZPM-CXCR4-AMD070
10.53Single8ZPNAMD31008ZPN-CXCR4-AMD3100
10.53Single9BA0A1AKN9BA0-CB1-A1AKN
10.53Single9IXXLTD49IXX-CysLT2-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
10.53Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
10.34Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
10.34Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
10.34Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
10.34Consensuscalcitonin_onOrthosteric Ligandctlike_on
10.34Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
10.34Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
10.34Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
10.34Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
10.34Consensuspac_onOrthosteric Ligandpac1_on
10.34Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
10.00Single4XT3Fractalkine4XT3-US28-Fractalkine
10.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
10.00Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
10.00Single6FJ3PTH6FJ3-PTH1-PTH
10.00Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
10.00Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
10.00Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
10.00Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
10.00Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
10.00Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
10.00Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
10.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
10.00Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.00Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
10.00Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
10.00Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
10.00Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
10.00Single8ZYYNeurotensin peptide 8-138ZYY-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
10.00Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
10.00Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
10.00Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
10.00Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
10.00Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
10.00Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
10.00Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
10.00Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
10.00Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
10.00Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
10.00Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
10.00Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
10.00Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
10.00Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
9.68Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
9.68Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
9.68Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
9.68Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
9.68Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
9.68Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
9.68Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
9.68Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
9.68Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
9.68Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
9.68Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
9.52Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
9.52Single5T1ABMS-6815T1A-CCR2-BMS-681-PubChem 12093170
9.52Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
9.52Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
9.52Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
9.52Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
9.52Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.52Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
9.52Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
9.52Single8ZYTNeurotensin peptide 8-138ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
9.52Single9B9ZA1AKO9B9Z-CB1-A1AKO
9.52Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
9.52Consensusep_offOrthosteric Ligandep4_off
9.52Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
9.38Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
9.38Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
9.38Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
9.38Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
9.38Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
9.38Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
9.38Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
9.09Single5TZRMK86665TZR-FFA1-MK8666
9.09Single7F1TMIP-1a7F1T-CCR5-MIP-1a
9.09Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
9.09Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
9.09Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
9.09Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
9.09Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
9.09Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single8ZW0PGD28ZW0-DP1-PGD2-Gs/β1/γ2
9.09Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
9.09Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
9.09Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
8.82Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
8.82Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
8.70Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
8.70Single4PY02MeSATP4PY0-P2Y12-2MeSATP
8.70Single4XEENeurotensin4XEE-NTS1-Neurotensin
8.70Single4XESNeurotensin4XES-NTS1-Neurotensin
8.70Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
8.70Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
8.70Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
8.70Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
8.70Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
8.70Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
8.70Single9BJKNAM9BJK-μ-Naloxone-NAM
8.70Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
8.70Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
8.70Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
8.57Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
8.57Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
8.57Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
8.57Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.33Single4BUONeurotensin4BUO-NTS1-Neurotensin
8.33Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
8.33Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
8.33Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
8.33Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
8.33Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
8.33Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
8.33Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
8.33Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
8.33Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.11Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
8.00Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
8.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
8.00Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
8.00Single8XQJJN2418XQJ-Apelin-JN241
8.00Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
8.00Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
7.89Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
7.69Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
7.69Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
7.69Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
7.69Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
7.69Single8KIGSHU91198KIG-MC3-SHU9119-Ca
7.69Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
7.41Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
7.41Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
7.41Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
7.41Single7SK5CXCL127SK5-ACKR3-CXCL12
7.41Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
7.14Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
7.14Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
7.14Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
7.14Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
7.14Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
6.90Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
6.90Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
6.67Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
6.67Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
6.67Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
6.67Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
6.67Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
6.67Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
6.67Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
6.67Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
6.67Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
6.45Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
6.45Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
6.25Single3OE8IT1t3OE8-CXCR4-IT1t
6.25Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
6.25Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
6.25Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
6.06Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
6.06Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
6.06Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
6.06Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
5.88Single3OE6IT1t3OE6-CXCR4-IT1t
5.88Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
5.88Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
5.88Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
5.88Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
5.88Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
5.88Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
5.71Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
5.71Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
5.56Single5L7IVismodegib5L7I-SMO-Vismodegib
5.56Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
5.56Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
5.56Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
5.56Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
5.56Single9JCPLPC9JCP-GPR4-LPC-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg4_on
5.56Consensusadgrg_on_gpOrthosteric Ligandadgrg2_on_gp adgrg4_on_gp
5.56Consensusgq_nucleotideOrthosteric Ligandgq_p2y
5.56Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
5.41Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
5.41Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
5.26Single3ODUIT1t3ODU-CXCR4-IT1t
5.26Single4K5YCP-3763954K5Y-CRF1-CP-376395
5.26Single5U09Taranabant5U09-CB1-Taranabant
5.26Single5ZKQABT-4915ZKQ-PAF-ABT-491
5.26Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
5.26Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
5.26Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
5.26Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
5.26Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
5.26Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
5.26Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
5.26Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
5.26Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
5.26Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
5.00Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
5.00Single6ZINSR486926ZIN-NTS1-SR48692
5.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
5.00Single7VV6C48/807VV6-MRGPRX2-C48/80
5.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
5.00Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single8IYXYL-3658IYX-GPR34-YL-365
5.00Single8JD6VU03647708JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
5.00Single8K2WAMG4878K2W-CXCR3-AMG487
5.00Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
5.00Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
5.00Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
5.00Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
4.76Single4QIMANTA XV4QIM-SMO-ANTA XV
4.76Single4Z9GCP-3763954Z9G-CRF1-CP-376395
4.76Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
4.76Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
4.76Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
4.76Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
4.76Single8GTIBMK-C2058GTI-CRF1-BMK-C205
4.55Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
4.55Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
4.55Single6Z4SSR486926Z4S-NTS1-SR48692
4.55Single8GTGBMK-I1528GTG-CRF1-BMK-I152
4.55Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
4.55Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.55Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
4.55Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
4.55Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
4.55Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
4.35Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
4.35Single4BV0Neurotensin4BV0-NTS1-Neurotensin
4.35Single5V56TC1145V56-SMO-TC114
4.35Single6OS1TRV0266OS1-AT1-TRV026
4.35Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
4.35Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
4.35Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
4.35Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
4.35Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
4.35Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
4.35Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Consensusneurotensin_onOrthosteric Ligandnts1_on
4.35Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
4.17Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
4.17Single6OS2TRV0266OS2-AT1-TRV026
4.17Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
4.17Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
4.17Single6YVRNTS8-136YVR-NTS1-NTS8-13
4.17Single8GTMBMK-C2038GTM-CRF1-BMK-C203
4.17Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
4.17Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
4.17Single8XQJJN2418XQJ-Apelin-JN241
4.17Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
4.17Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
4.17Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
4.17Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
4.17Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
4.17Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
4.17Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
4.00Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
4.00Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
4.00Single8JPFNeurotensin8JPF-NTS1-Neurotensin-SBI-553
4.00Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
4.00Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.00Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.85Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
3.85Single6KNMJN241-96KNM-Apelin-JN241-9
3.85Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
3.85Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
3.85Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
3.85Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
3.85Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
3.85Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
3.70Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.70Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
3.70Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
3.70Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
3.45Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
3.45Single9B5YLong-Acting PTH9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
3.45Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
3.45Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
3.45Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
3.33Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
3.12Single7SK3CXCL127SK3-ACKR3-CXCL12
3.03Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
3.03Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2

Consensus Members
Id Members
7E32 7E32-5-HT1D-Serotonin-Gi1/β1/γ2
Net Summary
Imin 3.21
Number of Linked Nodes 832
Number of Links 1024
Number of Hubs 168
Number of Links mediated by Hubs 636
Number of Communities 29
Number of Nodes involved in Communities 269
Number of Links involved in Communities 387
Path Summary
Number Of Nodes in MetaPath 112
Number Of Links MetaPath 111
Number of Shortest Paths 1089523
Length Of Smallest Path 3
Average Path Length 31.0964
Length of Longest Path 62
Minimum Path Strength 1.43
Average Path Strength 6.63375
Maximum Path Strength 26.94
Minimum Path Correlation 0.7
Average Path Correlation 0.979194
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.08333
Average % Of Corr. Nodes 42.6848
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 51.537
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
5ht1_on_gp5ht1a_on_gp
5ht1d_on_gp
5ht1e_on_gp
5ht1f_on_gp



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 5ht1d_on_gp.zip



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