Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Y37 7.512524
2A:A:H41 5.404536
3A:A:R42 7.5725409
4A:A:L43 3.334537
5A:A:L45 5.94438
6A:A:K53 7.3175439
7A:A:I56 2.962537
8A:A:M60 5.0925439
9A:A:V214 5.41436
10A:A:V217 3.8475435
11A:A:F219 6.57143738
12A:A:M221 4.65438
13A:A:F222 10.566517
14A:A:Q227 5.6575419
15A:A:K233 5.41719
16A:A:W234 6.06667619
17A:A:C237 3.558518
18A:A:F238 8.144519
19A:A:T242 4.435408
20A:A:V248 3.3825407
21A:A:L270 5.165406
22A:A:F273 5.35509
23A:A:W277 9.23506
24A:A:W281 11.214515
25A:A:F290 6.46439
26A:A:N292 4.6775439
27A:A:E314 4.8465126
28A:A:F315 9.0354126
29A:A:Y318 5.3325126
30A:A:E330 6.2075403
31A:A:V334 5.1575404
32A:A:K338 10.15254135
33A:A:Y339 7.5585133
34A:A:F340 9.445127
35A:A:R342 5.535134
36A:A:E344 7.6545125
37A:A:F345 6.8525408
38A:A:S349 4.2925407
39A:A:D354 10.57754193
40A:A:R356 9.6825192
41A:A:Y360 12.9425408
42A:A:F363 10.6785135
43A:A:T364 6.216539
44A:A:N371 7.48539
45A:A:R373 6.5375435
46A:A:F376 4.75838
47A:A:R385 6.025145
48A:A:L388 3.8865148
49A:A:L394 4.1656148
50B:B:L7 3.1925408
51B:B:I18 3.105407
52B:B:L30 3.945405
53B:B:I37 3.558502
54B:B:V40 4.97254163
55B:B:I43 3.0225403
56B:B:M45 3.868584
57B:B:R48 6.445427
58B:B:H54 8.62333629
59B:B:K57 11.3225419
60B:B:M61 3.78526
61B:B:W63 6.27833627
62B:B:V71 2.952508
63B:B:S72 5.16529
64B:B:D76 5.16714729
65B:B:K78 4.805408
66B:B:L79 5.534177
67B:B:I81 4.59254157
68B:B:W82 8.39429729
69B:B:D83 8.98428
70B:B:T86 6.11426
71B:B:N88 8.165427
72B:B:K89 6729
73B:B:H91 5.724155
74B:B:I93 4.9625407
75B:B:L95 5.42254178
76B:B:W99 9.03333619
77B:B:M101 6.178519
78B:B:Y105 4.3406
79B:B:N110 6.565414
80B:B:Y111 6.115414
81B:B:L117 3.574519
82B:B:I123 3.34167616
83B:B:Y124 5.975176
84B:B:L126 3.89754155
85B:B:E138 5.0375406
86B:B:L139 6.236519
87B:B:H142 6.68714719
88B:B:Y145 6.63125818
89B:B:C149 3.84418
90B:B:F151 4.66333609
91B:B:L152 3.5075403
92B:B:I157 4.608517
93B:B:V158 3.2175405
94B:B:T159 5.236519
95B:B:S160 4.04446
96B:B:D163 8.08419
97B:B:C166 3.81448
98B:B:L168 4.07446
99B:B:W169 8.17286718
100B:B:D170 5.865449
101B:B:F180 7.932547
102B:B:H183 8.07667649
103B:B:D186 5.764519
104B:B:V187 4.315449
105B:B:M188 5.0175418
106B:B:F199 7.45449
107B:B:S201 4.6075449
108B:B:C204 4.73333617
109B:B:D205 7.015449
110B:B:K209 10.288546
111B:B:W211 8.64333648
112B:B:Q220 6.3025407
113B:B:F222 7.5425468
114B:B:H225 8.58143769
115B:B:D228 8.462519
116B:B:I232 5.475468
117B:B:F234 4.7675405
118B:B:F235 6.3825816
119B:B:P236 6.3775417
120B:B:N237 8.795415
121B:B:F241 7.44667666
122B:B:D246 6.4775419
123B:B:D247 7.5475469
124B:B:T249 4.87566
125B:B:R251 12.602568
126B:B:L252 4.94417
127B:B:F253 6.77167666
128B:B:E260 9.0325466
129B:B:M262 5.928514
130B:B:T263 4.975461
131B:B:Y264 7.415615
132B:B:I269 5.245414
133B:B:F278 5.488517
134B:B:R283 7.365169
135B:B:L284 4.365405
136B:B:L285 4.7675416
137B:B:L286 3.3487
138B:B:Y289 6.88429717
139B:B:D290 5.34516
140B:B:N295 7.498516
141B:B:W297 6.505418
142B:B:H311 9.094589
143B:B:R314 11.098518
144B:B:L318 3.725406
145B:B:M325 4.044525
146B:B:V327 3.825486
147B:B:W332 11.5619
148B:B:D333 8.135489
149B:B:L336 4.968527
150B:B:K337 6.6625486
151B:B:W339 8.87589
152G:G:I9 4.4425402
153G:G:L19 2.1425409
154G:G:L37 3.385417
155G:G:Y40 8.815416
156G:G:H44 6.1625406
157G:G:D48 4.58167609
158G:G:L51 3.5285166
159G:G:N59 5.492529
160G:G:P60 6.3925429
161G:G:F61 4.50625828
162L:L:Y1 7.164570
163L:L:F6 6.405400
164L:L:Y10 8.7575400
165R:R:L119 5.4754202
166R:R:F126 5.862504
167R:R:Y133 5.0675497
168R:R:H137 3.68407
169R:R:L144 4.84459
170R:R:A147 2.7354218
171R:R:L157 4.0985108
172R:R:R161 6.7245109
173R:R:N162 4.74754108
174R:R:L168 5.6275409
175R:R:F169 4.1475408
176R:R:T171 4.644558
177R:R:F172 7.93658
178R:R:V179 4.205497
179R:R:F180 3.8925407
180R:R:K182 4.675696
181R:R:L186 3.5075496
182R:R:H194 7.2875494
183R:R:F197 4.8625492
184R:R:C202 4.155499
185R:R:H210 6.41833677
186R:R:F211 5.6458
187R:R:M214 4.27475
188R:R:T215 4.585458
189R:R:W219 9.71333659
190R:R:E223 8.6025409
191R:R:V225 2.6625406
192R:R:Y226 4.278508
193R:R:T234 3.855437
194R:R:F242 7.495406
195R:R:W250 7.256559
196R:R:P253 3.8875459
197R:R:W260 9.1875478
198R:R:E268 3.6575475
199R:R:W273 10.222579
200R:R:Y281 8.5125473
201R:R:W282 11.75476
202R:R:K286 7.9975406
203R:R:F300 5.4954118
204R:R:K310 6.4185149
205R:R:L334 4.7954119
206R:R:F338 6.4045118
207R:R:H341 5.97458
208R:R:Y342 9.4675458
209R:R:F345 6.87756
210R:R:R357 8.845456
211R:R:E361 7.16457
212R:R:Q368 5.09459
213R:R:L375 4.244237
214R:R:F378 4.0154218
215R:R:E382 6.4854109
216R:R:V383 2.58254109
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:R385 A:A:R389 1001.07YesNo054
2A:A:R356 A:A:R389 99.971.07YesNo024
3A:A:R283 A:A:R356 88.647219.19NoYes032
4A:A:K280 A:A:R283 88.60253.71NoNo053
5A:A:K280 A:A:W281 88.562123.21NoYes055
6A:A:W281 B:B:W332 81.92456.56YesYes159
7B:B:S316 B:B:W332 13.59864.94NoYes099
8B:B:C317 B:B:S316 13.43983.44NoNo079
9B:B:C317 B:B:M61 13.13234.86NoYes076
10A:A:R385 R:R:K310 48.38538.66YesYes1459
11A:A:Q384 R:R:K310 11.78139.49NoYes069
12A:A:D378 A:A:Y360 10.306516.09NoYes078
13B:B:L117 B:B:W99 27.00855.69YesYes199
14B:B:L117 B:B:Y145 49.96473.52YesYes198
15B:B:M188 B:B:Y145 50.15693.59YesYes188
16B:B:Q75 B:B:W99 28.683112.05NoYes199
17B:B:K57 B:B:W332 80.030123.21YesYes199
18B:B:K57 B:B:Q75 79.94156.78YesNo199
19A:A:C237 B:B:M101 24.67394.86YesYes189
20A:A:H357 A:A:R356 15.67497.9NoYes1972
21A:A:H357 A:A:W277 15.605723.27NoYes076
22A:A:W281 B:B:D290 10.9097.82YesYes156
23A:A:L394 A:A:R385 39.27633.64YesYes1485
24A:A:L388 A:A:L394 37.80866.92YesYes1488
25A:A:L388 R:R:L231 20.02214.15YesNo088
26A:A:L388 R:R:K310 40.46522.82YesYes1489
27A:A:Q384 R:R:L231 11.7482.66NoNo068
28B:B:M45 B:B:W339 12.26923.49YesYes849
29B:B:H311 B:B:T329 10.32216.85YesNo098
30B:B:D333 B:B:H311 16.41598.82YesYes899
31B:B:D312 B:B:D333 16.30592.66NoYes059
32B:B:D312 R:R:R156 16.353113.1NoNo057
33R:R:E386 R:R:R156 16.37814.65NoNo087
34R:R:E386 R:R:L157 16.30936.63NoYes1088
35R:R:H165 R:R:R161 13.71576.77NoYes099
36R:R:E223 R:R:H165 13.28428.62YesNo099
37A:A:L388 A:A:L393 59.1542.77YesNo088
38A:A:L393 R:R:L334 59.10944.15NoYes089
39R:R:I303 R:R:L334 20.37262.85NoYes089
40B:B:M188 B:B:S147 48.77144.6YesNo089
41B:B:S147 B:B:S160 48.39553.26NoYes096
42B:B:S160 B:B:V187 41.14336.46YesYes469
43B:B:H183 B:B:V187 36.86054.15YesYes499
44B:B:H183 B:B:K209 34.938318.34YesYes496
45B:B:K209 B:B:T221 33.517810.51YesNo067
46B:B:T221 G:G:E22 33.1298.47NoNo079
47B:B:I18 G:G:E22 32.89182.73YesNo079
48B:B:I18 G:G:L19 10.40021.43YesYes079
49B:B:I18 B:B:R22 21.50185.01YesNo076
50B:B:D258 B:B:R22 21.10719.53NoNo076
51B:B:G162 B:B:Y145 20.479810.14NoYes198
52B:B:G162 B:B:S161 20.14043.71NoNo199
53B:B:H142 B:B:S161 18.188413.95YesNo199
54B:B:H142 B:B:W169 11.23236.35YesYes198
55B:B:D258 B:B:Q220 17.944610.44NoYes077
56B:B:F222 B:B:Q220 13.97119.37YesYes087
57B:B:C271 B:B:D290 11.96283.11NoYes156
58B:B:C271 B:B:Y289 10.86684.03NoYes157
59R:R:E223 R:R:L168 27.30616.63YesYes099
60R:R:F172 R:R:L168 13.86127.31YesYes089
61R:R:F172 R:R:Q368 12.55379.37YesYes589
62R:R:Q368 R:R:Y342 23.11113.38YesYes598
63R:R:F217 R:R:I289 70.666313.82NoNo087
64L:L:Y1 R:R:I289 55.84216.04YesNo007
65R:R:L168 R:R:L220 12.1224.15YesNo099
66R:R:L220 R:R:Q368 11.95912.66NoYes099
67R:R:I303 R:R:N228 19.2347.08NoNo088
68R:R:L299 R:R:N228 48.23649.61NoNo088
69R:R:L299 R:R:V225 66.58162.98NoYes086
70R:R:L221 R:R:V225 64.4212.98NoYes076
71R:R:L221 R:R:S292 63.42153NoNo077
72R:R:F217 R:R:S292 62.95873.96NoNo087
73R:R:I306 R:R:L231 30.55365.71NoNo078
74R:R:I306 R:R:N302 29.89595.66NoNo2277
75R:R:N228 R:R:N302 29.78785.45NoNo087
76R:R:F338 R:R:L334 37.18027.31YesYes1189
77R:R:A224 R:R:F338 19.00286.93NoYes1188
78R:R:A224 R:R:L299 18.8554.73NoNo088
79L:L:Y1 R:R:H210 40.49997.62YesYes707
80L:L:Y1 R:R:W282 13.77936.75YesYes706
81R:R:E361 R:R:Y342 14.61848.98YesYes578
82R:R:E361 R:R:R357 10.15259.3YesYes576
83R:R:H210 R:R:S209 28.52724.18YesNo076
84R:R:K182 R:R:S209 26.41464.59YesNo066
85R:R:K182 R:R:V179 10.34093.04YesYes967
86R:R:K182 R:R:L186 12.44662.82YesYes966
87R:R:H210 R:R:W260 11.307710.58YesYes778
88R:R:I289 R:R:M214 14.32022.92NoYes075
89R:R:I285 R:R:M214 11.7055.83NoYes775
90R:R:I285 R:R:W260 11.13912.92NoYes778
91R:R:F338 R:R:L337 18.59177.31YesNo089
92R:R:K264 R:R:W260 13.896510.44NoYes778
93R:R:E268 R:R:K264 12.83382.7YesNo757
94A:A:C237 B:B:Q75 51.19673.05YesNo189
95R:R:E223 R:R:L337 18.493210.6YesNo099
96A:A:C237 B:B:L117 25.20613.17YesYes189
97B:B:M101 B:B:Y145 24.20898.38YesYes198
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:Y1 R:R:H210 7.62 7 Yes Yes 0 7 0 1
L:L:Y1 R:R:T213 8.74 7 Yes No 0 5 0 1
L:L:Y1 R:R:W282 6.75 7 Yes Yes 0 6 0 1
L:L:Y1 R:R:I289 6.04 7 Yes No 0 7 0 1
L:L:A2 R:R:R357 4.15 5 No Yes 0 6 0 1
L:L:A2 R:R:E361 4.53 5 No Yes 0 7 0 1
L:L:D3 R:R:V179 5.84 9 No Yes 0 7 0 1
L:L:D3 R:R:K182 5.53 9 No Yes 0 6 0 1
L:L:I5 R:R:D350 4.2 0 No No 0 5 0 1
L:L:I5 R:R:L354 5.71 0 No No 0 3 0 1
L:L:I5 R:R:R357 3.76 0 No Yes 0 6 0 1
L:L:F6 R:R:F126 8.57 0 Yes Yes 0 4 0 1
L:L:F6 R:R:V129 3.93 0 Yes No 0 6 0 1
L:L:F6 R:R:Y133 8.25 0 Yes Yes 0 7 0 1
L:L:F6 R:R:L362 4.87 0 Yes No 0 7 0 1
L:L:T7 R:R:K182 9.01 0 No Yes 0 6 0 1
L:L:N8 R:R:D274 4.04 0 No No 0 6 0 1
L:L:N8 R:R:D276 12.12 0 No No 0 6 0 1
L:L:Y10 R:R:F126 5.16 0 Yes Yes 0 4 0 1
L:L:Y10 R:R:F187 14.44 0 Yes No 0 4 0 1
L:L:R11 R:R:H194 11.28 0 No Yes 0 4 0 1
L:L:R11 R:R:D274 11.91 0 No No 0 6 0 1
L:L:V13 R:R:L119 2.98 20 No Yes 0 2 0 1
L:L:V13 R:R:E122 7.13 20 No No 0 4 0 1
L:L:L14 R:R:H194 9 0 No Yes 0 4 0 1
L:L:Q16 R:R:L119 5.32 0 No Yes 0 2 0 1
L:L:L17 R:R:L119 8.3 0 No Yes 0 2 0 1
L:L:L22 R:R:D193 2.71 0 No No 0 2 0 1
R:R:E122 R:R:L119 5.3 20 No Yes 4 2 1 1
R:R:F126 R:R:Y125 10.32 0 Yes No 4 4 1 2
R:R:V129 R:R:Y125 5.05 0 No No 6 4 1 2
R:R:K130 R:R:Y133 4.78 9 No Yes 5 7 2 1
R:R:D183 R:R:K130 4.15 9 No No 7 5 2 2
R:R:V179 R:R:Y133 3.79 9 Yes Yes 7 7 1 1
R:R:D183 R:R:Y133 3.45 9 No Yes 7 7 2 1
R:R:H137 R:R:V179 4.15 0 Yes Yes 7 7 2 1
R:R:K182 R:R:V179 3.04 9 Yes Yes 6 7 1 1
R:R:K182 R:R:L186 2.82 9 Yes Yes 6 6 1 2
R:R:K182 R:R:S205 3.06 9 Yes No 6 5 1 2
R:R:K182 R:R:S209 4.59 9 Yes No 6 6 1 2
R:R:F187 R:R:L186 4.87 0 No Yes 4 6 1 2
R:R:H194 R:R:T192 5.48 9 Yes No 4 4 1 2
R:R:F197 R:R:T192 9.08 9 Yes No 2 4 2 2
R:R:C195 R:R:D193 3.11 0 No No 4 2 1 1
R:R:F197 R:R:H194 3.39 9 Yes Yes 2 4 2 1
R:R:H210 R:R:V206 5.54 7 Yes No 7 5 1 2
R:R:H210 R:R:S209 4.18 7 Yes No 7 6 1 2
R:R:H210 R:R:W260 10.58 7 Yes Yes 7 8 1 2
R:R:H210 R:R:W282 5.29 7 Yes Yes 7 6 1 1
R:R:H210 R:R:I285 5.3 7 Yes No 7 7 1 2
R:R:I285 R:R:M214 5.83 7 No Yes 7 5 2 2
R:R:I289 R:R:M214 2.92 0 No Yes 7 5 1 2
R:R:F217 R:R:I289 13.82 0 No No 8 7 2 1
R:R:F217 R:R:Y342 11.35 0 No Yes 8 8 2 2
R:R:I285 R:R:W260 12.92 7 No Yes 7 8 2 2
R:R:D274 R:R:L275 8.14 0 No No 6 4 1 2
R:R:D276 R:R:W282 25.68 0 No Yes 6 6 1 1
R:R:K286 R:R:W282 9.28 0 Yes Yes 6 6 2 1
R:R:D350 R:R:K286 6.91 0 No Yes 5 6 1 2
R:R:E361 R:R:Y342 8.98 5 Yes Yes 7 8 1 2
R:R:F345 R:R:R357 18.17 5 Yes Yes 6 6 2 1
R:R:E361 R:R:F345 5.83 5 Yes Yes 7 6 1 2
R:R:L354 R:R:L358 6.92 0 No No 3 6 1 2
R:R:E361 R:R:R357 9.3 5 Yes Yes 7 6 1 1
R:R:L358 R:R:L362 2.77 0 No No 6 7 2 1
L:L:L17 R:R:E123 2.65 0 No No 0 2 0 1
L:L:S9 R:R:F126 2.64 0 No Yes 0 4 0 1
L:L:V13 R:R:F126 2.62 20 No Yes 0 4 0 1
L:L:Y10 R:R:S127 2.54 0 Yes No 0 2 0 1
L:L:G15 R:R:C195 1.96 0 No No 0 4 0 1
L:L:A19 R:R:C195 1.81 0 No No 0 4 0 1
R:R:A120 R:R:E123 1.51 0 No No 4 2 2 1
L:L:S18 R:R:D190 1.47 0 No No 0 3 0 1
R:R:E123 R:R:S124 1.44 0 No No 2 3 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
72.00Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
68.00Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
64.29Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
64.29Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
62.96Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
62.96Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
62.96Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
62.96Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
62.07Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
61.54Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
61.54Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
61.54Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
60.71Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
60.71Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
60.00Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
59.26Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
58.62Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
58.62Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
58.62Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
58.06Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
58.06Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
57.69Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
57.14Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
57.14Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
57.14Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
57.14Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
57.14Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
56.25Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
56.25Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
56.00Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
55.56Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
55.56Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
55.17Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
55.17Consensusglp_onOrthosteric Ligandglp1_on glp2_on
55.17Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
54.84Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
54.55Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
53.85Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
53.57Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
53.57Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
53.57Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
53.57Consensuspac_onOrthosteric Ligandpac1_on
53.33Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
53.33Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
53.33Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
53.33Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
53.33Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
53.12Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
53.12Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
51.85Single9B5YLong-Acting PTH9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
51.72Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
51.61Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
51.52Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
51.52Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
51.52Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
51.52Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
51.43Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
50.00Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
50.00Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
50.00Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
50.00Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
50.00Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
50.00Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
50.00Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
50.00Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
48.65Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
48.48Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
48.48Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
48.28Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
48.28Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
47.22Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
47.06Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
47.06Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
46.88Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
46.67Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
46.67Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
46.43Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
45.71Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
45.71Consensuspth_onOrthosteric Ligandpth1_on pth2_on
45.45Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
45.16Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
45.16Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
45.16Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
45.16Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
44.83Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
44.83Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
44.44Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
43.75Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
43.75Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
43.75Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
43.33Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
41.94Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
40.62Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
40.00Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
39.39Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
39.39Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
39.39Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
38.89Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
38.71Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
38.71Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
38.24Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
37.93Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
37.50Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
37.50Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
37.50Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
37.14Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
37.14Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
37.04Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
37.04Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
36.67Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
36.36Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
36.36Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
36.36Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
36.11Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
35.48Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
35.29Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
35.29Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
35.00Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
34.48Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
34.38Consensuscalcitonin_onOrthosteric Ligandctlike_on
33.33Single6FJ3PTH6FJ3-PTH1-PTH
33.33Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
33.33Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
33.33Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
33.33Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
32.35Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
32.26Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
32.26Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
32.14Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
31.43Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
31.43Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
31.25Single9BLCCagrilintide backbone (non-acylated)9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
31.25Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
30.95Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
30.56Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
30.30Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
29.73Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
29.41Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
29.41Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
29.41Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
29.03Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
28.95Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
28.57Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
28.12Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
27.78Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
27.78Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
27.78Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
27.78Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
27.59Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
27.27Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
27.27Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
27.27Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
26.92Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
26.92Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
26.67Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
26.67Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
26.47Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
26.47Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
26.19Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
25.93Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
25.81Single4XT1Fractalkine4XT1-US28-Fractalkine
25.81Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
25.81Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
25.71Single4XT3Fractalkine4XT3-US28-Fractalkine
25.71Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
25.71Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
25.71Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
25.71Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
25.71Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
25.64Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
25.00Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
25.00Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
25.00Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
25.00Single7TUYGSK682753A7TUY-GPR183-GSK682753A
25.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
25.00Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
25.00Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
25.00Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
25.00Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
25.00Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
24.14Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
24.14Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
24.14Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
24.14Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
24.14Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
24.14Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
24.00Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
24.00Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
23.68Single6IGKEndothelin-36IGK-ETB-Endothelin-3
23.68Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
23.68Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
23.68Consensusbombesin_onOrthosteric Ligandbb2_on
23.68Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
23.68Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
23.68Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
23.53Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
23.53Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
23.53Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
23.53Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
23.53Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
23.53Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
23.53Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
23.53Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
23.53Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
23.53Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
23.53Consensusvasop-oxy_onOrthosteric Ligandv2_on
23.53Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
23.33Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
23.33Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
23.33Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
23.33Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
23.08Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
23.08Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
23.08Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
23.08Single9JFUNE52-QQ579JFU-GPR4-NE52-QQ57
23.08Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
22.86Single8ZRTET-18ZRT-ETB-ET-1
22.86Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
22.86Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
22.58Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
22.58Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
22.58Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
22.58Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
22.58Single9M0RNeuropeptide VF9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
22.50Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
22.22Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
22.22Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
22.22Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
22.22Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
22.22Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
22.22Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
22.22Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
22.22Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
22.22Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
22.22Consensushca_on_gpOrthosteric Ligandhca2_on_gp
21.88Single7QA8Peptide7QA8-STE2-Peptide
21.88Single7QA8Peptide7QA8-STE2-Peptide
21.88Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
21.88Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
21.88Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
21.88Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
21.88Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
21.88Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
21.88Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
21.88Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.62Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
21.62Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
21.62Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
21.62Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
21.62Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
21.62Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
21.62Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
21.62Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
21.62Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
21.43Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
21.43Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
21.43Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
21.43Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
21.43Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
21.43Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
21.43Single8XYKVUF106618XYK-CXCR3-VUF10661-Go/β1/γ2
21.43Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
21.43Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
21.43Single9KPFSA09KPF-TAS2R16-SA0-Gi1/β1/γ2
21.43Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
21.43Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
21.43Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
21.43Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
21.21Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
21.21Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
21.21Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
21.21Single7XNACYN1548067XNA-SST2-CYN154806
21.21Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
21.21Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
21.21Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
21.21Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
21.21Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
21.21Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
21.21Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
21.05Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
21.05Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
21.05Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
21.05Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
20.93Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
20.83Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
20.69Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
20.69Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
20.69Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
20.69Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
20.69Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
20.69Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
20.69Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
20.69Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
20.69Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
20.69Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
20.69Consensusrelaxin_onOrthosteric Ligandrxfp4_on
20.69Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
20.59Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
20.59Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
20.59Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
20.59Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
20.59Consensusangiotensin_onOrthosteric Ligandat1_on
20.59Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
20.59Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
20.59Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
20.59Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
20.59Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
20.59Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
20.51Single5GLHEndothelin-15GLH-ETB-Endothelin-1
20.51Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
20.51Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
20.51Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
20.00Single4N4WSANT-14N4W-SMO-SANT-1
20.00Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
20.00Single6JODAngiotensin II6JOD-AT2-Angiotensin II
20.00Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
20.00Single6KQICP559406KQI-CB1-CP55940-Org27569
20.00Single6LI0C176LI0-GPR52-C17
20.00Single6OS2TRV0266OS2-AT1-TRV026
20.00Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
20.00Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
20.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
20.00Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
20.00Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
20.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
20.00Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
20.00Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
20.00Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
20.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
20.00Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
20.00Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
20.00Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
20.00Single8JWY2-1188JWY-A2A-2-118
20.00Single8JWZAB9288JWZ-A2A-AB928-Na
20.00Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
20.00Single8K5BNiacin8K5B-HCA2-Niacin
20.00Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
20.00Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.00Single8XJNCloprosetnol8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
20.00Single8XYIVUF106618XYI-CXCR3-VUF10661
20.00Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9DGIZ85267113509DGI-CB1-Z8526711350
20.00Single9GGGI-BOP9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
20.00Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
20.00Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
20.00Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
20.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
20.00Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
20.00Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
20.00Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
20.00Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
19.51Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
19.51Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
19.44Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
19.44Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
19.44Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
19.44Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
19.44Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
19.44Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
19.44Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
19.44Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
19.44Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
19.35Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
19.35Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
19.35Single7EZCUKA7EZC-A2A-UKA
19.35Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
19.35Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
19.35Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
19.35Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
19.35Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
19.35Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
19.35Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
19.35Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
19.35Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
19.35Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Single8XJOU466198XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Single9M54Neuropeptide VF9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
19.35Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
19.35Consensuschemerin_onOrthosteric Ligandcml1_on
19.35Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
19.35Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
19.35Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.35Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.35Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
19.35Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
19.35Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
19.35Consensustp_onOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Consensustp_on_gpOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Single6AKXA4R6AKX-CCR5-A4R
19.23Single6AKYMaraviroc6AKY-CCR5-Maraviroc
19.23Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
19.23Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
19.23Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
19.23Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
19.23Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
19.23Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
19.23Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
19.23Consensusangiotensin_offOrthosteric Ligandat1_off
19.23Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
19.23Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
19.23Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
18.92Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
18.92Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
18.92Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
18.92Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
18.92Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
18.92Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
18.92Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
18.75Single4UG2CGS216804UG2-A2A-CGS21680
18.75Single5ZTYAM102575ZTY-CB2-AM10257
18.75Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
18.75Single7SK9CCX6627SK9-ACKR3-CCX662
18.75Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
18.75Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
18.75Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
18.75Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
18.75Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
18.75Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
18.75Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
18.75Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
18.75Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
18.75Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
18.75Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
18.75Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
18.60Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
18.52Single4MBSMaraviroc4MBS-CCR5-Maraviroc
18.52Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
18.52Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
18.52Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
18.52Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
18.52Single7F61PF-036547467F61-H3-PF-03654746
18.52Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
18.52Single7T32ZM-2413857T32-A2A-ZM-241385
18.52Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
18.52Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
18.52Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
18.52Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
18.52Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
18.52Single8K5CAcipimox8K5C-HCA2-Acipimox
18.52Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
18.52Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
18.52Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
18.52Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Single9KPDSA09KPD-TAS2R16-SA0-chim(Gs-CtGt3)/β1/γ2
18.52Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
18.52Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
18.52Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
18.52Consensushca_onOrthosteric Ligandhca2_on
18.42Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
18.42Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
18.42Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
18.42Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
18.42Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
18.42Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
18.18Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
18.18Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
18.18Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
18.18Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
18.18Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
18.18Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
18.18Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
18.18Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
18.18Consensuslpl_onOrthosteric Ligands1p_on lpa_on
18.18Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
18.18Consensussomatostatin_offOrthosteric Ligandsst2_off
17.95Single6IGLIRL16206IGL-ETB-IRL1620
17.95Single8IY6Endothelin-18IY6-ETB-Endothelin-1
17.95Consensusendothelin_onOrthosteric Ligandetb_on eta_on
17.86Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
17.86Single4YAYZD-71554YAY-AT1-ZD-7155
17.86Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
17.86Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
17.86Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
17.86Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
17.86Single7V3ZCP559407V3Z-CB1-CP55940
17.86Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
17.86Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
17.86Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
17.86Single8K5DGSK2560738K5D-HCA2-GSK256073
17.86Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
17.86Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
17.86Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
17.86Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
17.86Single9CHXS-Carazolol9CHX-β2-S-Carazolol
17.86Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
17.86Single9KFJPubChem 1383196749KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
17.86Consensusa3_onOrthosteric Liganda3a_on
17.86Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
17.65Single3QAKUK-4320973QAK-A2A-UK-432097
17.65Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
17.65Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
17.65Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
17.65Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
17.65Single9E82SDF-1-beta9E82-ACKR3-SDF-1-β-Arrestin2
17.65Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
17.65Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
17.65Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
17.65Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
17.65Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
17.65Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
17.65Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
17.50Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
17.50Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
17.50Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
17.50Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
17.39Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
17.39Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
17.24Single4JKVTaladegib4JKV-SMO-Taladegib
17.24Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
17.24Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
17.24Single6D26Fevipiprant6D26-DP2-Fevipiprant
17.24Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
17.24Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
17.24Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
17.24Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
17.24Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
17.24Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
17.24Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
17.24Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
17.24Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.24Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
17.24Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
17.24Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
17.24Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
17.24Single8TF5Oleic acid8TF5-GPR6-Oleic acid
17.24Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
17.24Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
17.24Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
17.24Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
17.24Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
17.24Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
17.24Single8ZVZBW245C8ZVZ-DP1-BW245C-Gs/β1/γ2
17.24Single9B9ZA1AKO9B9Z-CB1-A1AKO
17.24Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
17.24Single9EHSLUF76029EHS-A3A-LUF7602
17.24Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
17.24Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
17.24Consensusa3_on_gpOrthosteric Liganda3a_on_gp
17.24Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
17.24Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
17.24Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
17.24Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
17.24Consensusdp_offOrthosteric Liganddp2_off
17.24Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
17.24Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
17.24Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
17.24Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
17.24Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
17.24Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.24Consensustrace-amine_onOrthosteric Ligandta1_on
17.14Single5WF5UK-4320975WF5-A2A-UK-432097
17.14Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
17.14Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
17.14Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
17.14Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
17.14Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.14Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.14Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
17.14Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
17.14Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.14Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
17.14Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
17.14Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
17.14Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
17.14Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
17.14Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
17.07Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
17.07Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
16.67Single2YDVNECA2YDV-A2A-NECA
16.67Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
16.67Single4UHRCGS216804UHR-A2A-CGS21680
16.67Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
16.67Single5G53NECA5G53-A2A-NECA-Gs
16.67Single5V56TC1145V56-SMO-TC114
16.67Single5V57TC1145V57-SMO-TC114
16.67Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
16.67Single5XR8AM8415XR8-CB1-AM841
16.67Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
16.67Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
16.67Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
16.67Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
16.67Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
16.67Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
16.67Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
16.67Single7FEECP559407FEE-CB1-CP55940-ZCZ011
16.67Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
16.67Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
16.67Single7PX4PSB-21137PX4-A2A-PSB-2113
16.67Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
16.67Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
16.67Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
16.67Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
16.67Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
16.67Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
16.67Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
16.67Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
16.67Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
16.67Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
16.67Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
16.67Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
16.67Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
16.67Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
16.67Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
16.67Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
16.67Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
16.67Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
16.67Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
16.67Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
16.67Single9EGOYVF9EGO-CB1-YVF-Gi1/β1/γ2
16.67Single9I54A1IZV9I54-D1-A1IZV-Gs/β1/γ2
16.67Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
16.67Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
16.67Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
16.67Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
16.67Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
16.67Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
16.67Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
16.67Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
16.67Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
16.67Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
16.67Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
16.28Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
16.22Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
16.22Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
16.22Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
16.22Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
16.22Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
16.22Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
16.22Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
16.22Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
16.22Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
16.22Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
16.22Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
16.22Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
16.22Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
16.22Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
16.22Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
16.22Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
16.13Single4XEENeurotensin4XEE-NTS1-Neurotensin
16.13Single4XESNeurotensin4XES-NTS1-Neurotensin
16.13Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
16.13Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
16.13Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
16.13Single6IIURamatroban6IIU-TXA2-Ramatroban
16.13Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
16.13Single6YVRNTS8-136YVR-NTS1-NTS8-13
16.13Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
16.13Single7DFPSpiperone7DFP-D2-Spiperone
16.13Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
16.13Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
16.13Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
16.13Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
16.13Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
16.13Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
16.13Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
16.13Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.13Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
16.13Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
16.13Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
16.13Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
16.13Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
16.13Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
16.13Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
16.13Single9AU0BW245C9AU0-DP1-BW245C-Gs/β1/γ2
16.13Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
16.13Single9GL2Befiradol9GL2-5-HT1A-Befiradol-Gs/β1/γ2
16.13Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
16.13Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
16.13Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
16.13Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
16.13Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
16.13Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
16.13Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
16.13Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
16.13Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
16.13Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
16.13Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
16.13Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
16.13Consensuslpa_offOrthosteric Ligandlpa1_off
16.13Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
16.13Consensusorexin_onOrthosteric Ligandox2_on
16.13Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
16.00Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
16.00Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.00Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
16.00Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
16.00Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
16.00Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
15.79Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
15.79Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
15.79Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
15.79Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
15.79Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
15.79Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
15.79Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
15.62Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
15.62Single4BUONeurotensin4BUO-NTS1-Neurotensin
15.62Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
15.62Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
15.62Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
15.62Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.62Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
15.62Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
15.62Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
15.62Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
15.62Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
15.62Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
15.62Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
15.62Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
15.62Single9DYEBuspirone9DYE-5-HT1A-Buspirone-Go/β1/γ2
15.62Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
15.62Single9GG5U466199GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.62Single9M1HProstaglandin E29M1H-EP1-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
15.62Consensuscck_onOrthosteric Ligandccka_on cckb_on
15.62Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
15.62Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
15.62Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
15.62Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
15.62Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
15.62Consensusprostanoid_offOrthosteric Ligandep_off dp_off
15.56Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
15.56Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
15.38Single3OE9IT1t3OE9-CXCR4-IT1t
15.38Single5L7IVismodegib5L7I-SMO-Vismodegib
15.38Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
15.38Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
15.38Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
15.38Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
15.38Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
15.38Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
15.38Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
15.38Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
15.38Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
15.38Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
15.38Single9B9Y7DY9B9Y-CB1-7DY
15.38Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
15.38Single9LMPNE52-QQ579LMP-GPR4-NE52-QQ57
15.38Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg4_on
15.38Consensusadgrg_on_gpOrthosteric Ligandadgrg2_on_gp adgrg4_on_gp
15.15Single3NY9ICI118-5513NY9-β2-ICI118-551
15.15Single5WF6UK-4320975WF6-A2A-UK-432097
15.15Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
15.15Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
15.15Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
15.15Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
15.15Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
15.15Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
15.15Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
15.15Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
15.15Single8QJ2pN1628QJ2-MC4-pN162-Gs
15.15Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
15.15Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
15.15Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
15.15Single9IPYJR14a9IPY-C3aB-JR14a
15.15Single9MD1Buspirone9MD1-5-HT1A-Buspirone-Gz/β1/γ2
15.15Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
15.00Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
15.00Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
15.00Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
15.00Consensusbradykinin_onOrthosteric Ligandbk2_on
15.00Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
15.00Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
15.00Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
14.81Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
14.81Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
14.81Single4BWBNeurotensin4BWB-NTS1-Neurotensin
14.81Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
14.81Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
14.81Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
14.81Single5U09Taranabant5U09-CB1-Taranabant
14.81Single5ZKQABT-4915ZKQ-PAF-ABT-491
14.81Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
14.81Single6ME2Ramelteon6ME2-MT1-Ramelteon
14.81Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
14.81Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
14.81Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
14.81Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
14.81Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
14.81Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
14.81Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
14.81Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
14.81Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
14.81Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
14.81Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
14.81Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.81Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.81Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
14.81Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
14.81Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
14.81Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
14.81Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
14.81Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
14.81Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
14.81Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
14.81Single8IWESpermidine8IWE-TA9-Spermidine
14.81Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
14.81Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
14.81Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
14.81Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
14.81Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
14.81Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
14.81Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
14.81Single9K6LSA09K6L-TAS2R16-SA0-Gi2/β1/γ2
14.81Consensusalpha2_offOrthosteric Ligandalpha2c_off
14.81Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
14.81Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
14.71Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
14.71Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
14.71Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
14.71Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
14.71Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
14.71Single8PKMBefiradol8PKM-5-HT1A-Befiradol-Gi1/β1/γ1
14.71Single8WDTphotoNECA8WDT-A2A-photoNECA
14.71Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.71Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
14.71Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
14.71Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
14.71Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
14.71Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
14.71Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
14.71Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
14.71Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
14.71Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
14.29Single2YDOAdenosine2YDO-A2A-Adenosine
14.29Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
14.29Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
14.29Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
14.29Single5IU7Q274563465IU7-A2A-Q27456346-Na
14.29Single5IUBQ274563445IUB-A2A-Q27456344-Na
14.29Single5JTBZM-2413855JTB-A2A-ZM-241385
14.29Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
14.29Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
14.29Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
14.29Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
14.29Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
14.29Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
14.29Single6PS0S-Carazolol6PS0-β2-S-Carazolol
14.29Single6PS4ICI118-5516PS4-β2-ICI118-551
14.29Single6PS5S-Propranolol6PS5-β2-S-Propranolol
14.29Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
14.29Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
14.29Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
14.29Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
14.29Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
14.29Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
14.29Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
14.29Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
14.29Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Single7T94LY21196207T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
14.29Single7UL3Famotidine7UL3-H2-Famotidine
14.29Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
14.29Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
14.29Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
14.29Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
14.29Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
14.29Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
14.29Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
14.29Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
14.29Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
14.29Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
14.29Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
14.29Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
14.29Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8IHKAcifran8IHK-HCA3-Acifran
14.29Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
14.29Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
14.29Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
14.29Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
14.29Single8K2WAMG4878K2W-CXCR3-AMG487
14.29Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
14.29Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
14.29Single8RLNLUF58348RLN-A2A-LUF5834
14.29Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
14.29Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
14.29Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
14.29Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
14.29Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
14.29Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
14.29Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
14.29Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
14.29Single9AS5Mescaline9AS5-5-HT2A-Mescaline
14.29Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9BA0A1AKN9BA0-CB1-A1AKN
14.29Single9JH3CMF-0199JH3-Apelin-CMF-019-Gi1/β1/γ2
14.29Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
14.29Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
14.29Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
14.29Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
14.29Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
14.29Consensusa2_offOrthosteric Liganda2a_off
14.29Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
14.29Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
14.29Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
14.29Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
14.29Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
14.29Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
14.29Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
13.89Single6PT2KGCHM076PT2-δ-KGCHM07
13.89Single6W25SHU91196W25-MC4-SHU9119-Ca
13.89Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
13.89Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
13.89Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
13.89Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
13.89Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
13.89Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
13.89Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
13.89Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
13.89Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
13.89Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single2Y04Salbutamol2Y04-β1-Salbutamol
13.79Single3EMLZM-2413853EML-A2A-ZM-241385
13.79Single3NY8ICI118-5513NY8-β2-ICI118-551
13.79Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
13.79Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
13.79Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
13.79Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
13.79Single4GBRS-Carazolol4GBR-β2-S-Carazolol
13.79Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
13.79Single4QKX35V4QKX-β2-35V
13.79Single5DHHSB-6121115DHH-NOP-SB-612111
13.79Single5IU8Q274563475IU8-A2A-Q27456347-Na
13.79Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
13.79Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
13.79Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
13.79Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
13.79Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
13.79Single5T04Neurotensin5T04-NTS1-Neurotensin
13.79Single5UENDU1725UEN-A1-DU172
13.79Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
13.79Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
13.79Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
13.79Single6GPSMK08126GPS-CCR2-MK0812
13.79Single6H7MSalbutamol6H7M-β1-Salbutamol
13.79Single6IIVDaltroban6IIV-TXA2-Daltroban
13.79Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
13.79Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
13.79Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
13.79Single6PS1Timolol6PS1-β2-Timolol
13.79Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
13.79Single6S0LZM-2413856S0L-A2A-ZM-241385
13.79Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
13.79Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
13.79Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
13.79Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
13.79Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
13.79Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
13.79Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
13.79Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
13.79Single7PYRPSB-21157PYR-A2A-PSB-2115
13.79Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
13.79Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
13.79Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
13.79Single7UL4Alvimopan7UL4-μ-Alvimopan
13.79Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
13.79Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
13.79Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
13.79Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
13.79Single7WC7Lisuride7WC7-5-HT2A-Lisuride
13.79Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
13.79Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
13.79Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
13.79Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
13.79Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
13.79Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
13.79Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
13.79Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
13.79Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
13.79Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
13.79Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
13.79Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
13.79Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
13.79Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
13.79Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
13.79Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
13.79Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
13.79Single8JJOAlprenolol8JJO-β2-Alprenolol
13.79Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
13.79Single8PJKST1718PJK-5-HT1A-ST171-Gi1/β1/γ1
13.79Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
13.79Single8T1WCVN4248T1W-GPR6-CVN424
13.79Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
13.79Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
13.79Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
13.79Single8ZYYNeurotensin peptide 8-138ZYY-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
13.79Single9AS1DMT9AS1-5-HT2A-DMT
13.79Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
13.79Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
13.79Single9H37A1IR09H37-A2A-A1IR0-Na
13.79Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
13.79Consensus5ht5_onOrthosteric Ligand5ht5a_on
13.79Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
13.79Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
13.79Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
13.79Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
13.79Consensusblt_onOrthosteric Ligandblt1_on
13.79Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
13.79Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
13.79Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
13.79Consensusdopamine_offOrthosteric Ligandd2_off d3_off
13.79Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
13.79Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
13.79Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
13.79Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
13.79Consensusleukotriene_onOrthosteric Ligandblt_on
13.79Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
13.79Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
13.79Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
13.79Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
13.73Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
13.51Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
13.51Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
13.51Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
13.51Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
13.51Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
13.51Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
13.51Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
13.33Single2RH1S-Carazolol2RH1-β2-S-Carazolol
13.33Single2Y03Isoprenaline2Y03-β1-Isoprenaline
13.33Single2YCWS-Carazolol2YCW-β1-S-Carazolol
13.33Single5C1MBU725C1M-μ-BU72
13.33Single5D6LS-Carazolol5D6L-β2-S-Carazolol
13.33Single5IUAQ274563485IUA-A2A-Q27456348-Na
13.33Single5JQHS-Carazolol5JQH-β2-S-Carazolol
13.33Single5N2RPSB-365N2R-A2A-PSB-36-Na
13.33Single5N2SPSB365N2S-A1-PSB36
13.33Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
13.33Single5T1ABMS-6815T1A-CCR2-BMS-681-PubChem 12093170
13.33Single5TVNLSD5TVN-5-HT2B-LSD
13.33Single5WIUNemonapride5WIU-D4-Nemonapride
13.33Single5WIVNemonapride5WIV-D4-Nemonapride-Na
13.33Single5X7DS-Carazolol5X7D-β2-S-Carazolol-Cmpd-15
13.33Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
13.33Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
13.33Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
13.33Single6E67BI1671076E67-β2-BI167107-Gs(CT)
13.33Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
13.33Single6GPXMK08126GPX-CCR2-MK0812
13.33Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
13.33Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
13.33Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
13.33Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
13.33Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
13.33Single6PS6Timolol6PS6-β2-Timolol
13.33Single6S0QZM-2413856S0Q-A2A-ZM-241385
13.33Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
13.33Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
13.33Single7C4SS1P7C4S-S1P3-S1P
13.33Single7C61Ergotamine7C61-5-HT1B-Ergotamine
13.33Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
13.33Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
13.33Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
13.33Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
13.33Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
13.33Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
13.33Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
13.33Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
13.33Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
13.33Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
13.33Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
13.33Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
13.33Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
13.33Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
13.33Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
13.33Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
13.33Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
13.33Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.33Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.33Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.33Single8GNEKW-63568GNE-A2A-KW-6356-Na
13.33Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
13.33Single8JXSPF-61428JXS-D1-PF-6142
13.33Single8QOTNanobody-E8QOT-μ-Nanobody-E
13.33Single8S4DCMF-0198S4D-Apelin-CMF-019
13.33Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.33Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.33Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
13.33Single8ZYTNeurotensin peptide 8-138ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
13.33Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single9F33FOB02-04A9F33-D3-FOB02-04A-Go/β1/γ2
13.33Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
13.33Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
13.33Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
13.33Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
13.33Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
13.33Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
13.33Consensusadenosine_offOrthosteric Liganda1_off a2_off
13.33Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
13.33Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
13.33Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
13.33Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
13.33Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
13.33Consensusamine_offonOrthosteric Ligandamine_off amine_on
13.33Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
13.33Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
13.33Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
13.33Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
13.33Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
13.33Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.33Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
13.33Consensusep_offOrthosteric Ligandep4_off
13.33Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
13.33Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
13.33Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
13.33Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
13.16Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
13.16Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
13.16Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
13.16Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
13.16Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
13.16Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
13.16Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
13.04Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
12.90Single3P0GBI1671073P0G-β2-BI167107
12.90Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
12.90Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
12.90Single4BV0Neurotensin4BV0-NTS1-Neurotensin
12.90Single4DJHJDTic4DJH-κ-JDTic
12.90Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
12.90Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
12.90Single5D5AS-Carazolol5D5A-β2-S-Carazolol
12.90Single5D5BS-Carazolol5D5B-β2-S-Carazolol
12.90Single5XRAAM115425XRA-CB1-AM11542
12.90Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
12.90Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
12.90Single6H7JIsoprenaline6H7J-β1-Isoprenaline
12.90Single6J21Aprepitant6J21-NK1-Aprepitant
12.90Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
12.90Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
12.90Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
12.90Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
12.90Single6OS1TRV0266OS1-AT1-TRV026
12.90Single6TQ7SB-3348676TQ7-OX1-SB-334867
12.90Single6WGTLSD6WGT-5-HT2A-LSD
12.90Single7B6WCyclazosin7B6W-α1b-Cyclazosin
12.90Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
12.90Single7F1TMIP-1a7F1T-CCR5-MIP-1a
12.90Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
12.90Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
12.90Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
12.90Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
12.90Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
12.90Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
12.90Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
12.90Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
12.90Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
12.90Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.90Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
12.90Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
12.90Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
12.90Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
12.90Single8E0GBU728E0G-μ-BU72
12.90Single8EA0Iperoxo8EA0-M3-Iperoxo
12.90Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
12.90Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
12.90Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
12.90Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
12.90Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
12.90Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
12.90Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
12.90Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
12.90Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
12.90Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
12.90Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
12.90Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
12.90Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
12.90Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
12.90Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
12.90Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
12.90Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
12.90Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
12.90Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
12.90Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
12.90Single8ZW0PGD28ZW0-DP1-PGD2-Gs/β1/γ2
12.90Single8ZWFJR14a8ZWF-C3aB-JR14a
12.90Single9IK9SST analogue9IK9-SST1-SST analogue-Gi1/β1/γ2
12.90Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
12.90Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
12.90Consensusa2_onOrthosteric Liganda2b_on
12.90Consensusa2_on_gpOrthosteric Liganda2b_on_gp
12.90Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
12.90Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
12.90Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
12.90Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
12.90Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
12.90Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
12.90Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
12.90Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
12.90Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
12.90Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
12.90Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
12.90Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
12.90Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
12.90Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
12.90Consensuslpa_onOrthosteric Ligandlpa1_on
12.90Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
12.90Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
12.90Consensusneurotensin_onOrthosteric Ligandnts1_on
12.90Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
12.90Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
12.82Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
12.82Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
12.50Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
12.50Single3D4STimolol3D4S-β2-Timolol
12.50Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
12.50Single4AMIBucindolol4AMI-β1-Bucindolol
12.50Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
12.50Single4LDEBI1671074LDE-β2-BI167107
12.50Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
12.50Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
12.50Single6A93Risperidone6A93-5-HT2A-Risperidone
12.50Single6CM4Risperidone6CM4-D2-Risperidone
12.50Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
12.50Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
12.50Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
12.50Single6MXTSalmeterol6MXT-β2-Salmeterol
12.50Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
12.50Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
12.50Single6ZG4HTL00099366ZG4-M1-HTL0009936
12.50Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
12.50Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
12.50Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
12.50Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
12.50Single7YITNalfurafine7YIT-κ-Nalfurafine
12.50Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
12.50Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
12.50Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
12.50Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
12.50Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
12.50Single8HS2Fab0468HS2-GPR20-Fab046
12.50Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
12.50Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8JJ8Formoterol8JJ8-β2-Formoterol
12.50Single8JJLOlodaterol8JJL-β2-Olodaterol
12.50Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
12.50Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
12.50Single8PWNTheophylline8PWN-A2A-Theophylline
12.50Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
12.50Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
12.50Single9M4QDoxazosin9M4Q-Alpha1A-Doxazosin
12.50Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
12.50Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
12.50Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
12.50Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
12.50Consensusalpha1_offOrthosteric Ligandalpha1a_off
12.50Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
12.50Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
12.50Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
12.50Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
12.50Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
12.50Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
12.50Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
12.50Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
12.50Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
12.50Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
12.50Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
12.50Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
12.50Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
12.50Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
12.50Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
12.20Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
12.20Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
12.12Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
12.12Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
12.12Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
12.12Single5X93K-87945X93-ETB-K-8794
12.12Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
12.12Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
12.12Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
12.12Single6H7LDobutamine6H7L-β1-Dobutamine
12.12Single6IBLArformoterol6IBL-β1-Arformoterol
12.12Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
12.12Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
12.12Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
12.12Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
12.12Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
12.12Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
12.12Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
12.12Single7UM4AS26747237UM4-5-HT5A-AS2674723
12.12Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
12.12Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.12Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
12.12Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
12.12Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
12.12Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
12.12Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
12.12Single8JPFNeurotensin8JPF-NTS1-Neurotensin-SBI-553
12.12Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
12.12Single8XVUCXCL28XVU-CXCR2-CXCL2
12.12Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
12.12Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
12.12Single9AS02-bromo-LSD9AS0-5-HT2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
12.12Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
12.12Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
12.12Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
12.12Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
12.12Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
12.12Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
12.12Consensusendothelin_offOrthosteric Ligandetb_off
12.12Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
12.12Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
12.12Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Single8A2OTheophylline8A2O-A2A-Theophylline-Na
12.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.00Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
12.00Single9CHUNoradrenaline9CHU-β2-Noradrenaline
12.00Single9EE9Adenosine9EE9-A2A-Adenosine-Gs/β1/γ2
11.90Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
11.90Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
11.76Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
11.76Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
11.76Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
11.76Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
11.76Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
11.76Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
11.76Single7XN9L-054,5227XN9-SST2-L-054,522
11.76Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
11.76Single8X5YAstemizole8X5Y-H1-Astemizole
11.76Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
11.76Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
11.76Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
11.76Consensuskisspeptin_onOrthosteric Ligandkiss1_on
11.76Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
11.76Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
11.54Single3OE6IT1t3OE6-CXCR4-IT1t
11.54Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
11.54Single6ME5Agomelatine6ME5-MT1-Agomelatine
11.54Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
11.54Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
11.54Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
11.54Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
11.54Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
11.54Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.54Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
11.54Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
11.54Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
11.54Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
11.54Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
11.54Single9LRCHistamine9LRC-H4-Histamine
11.54Single9LREHistamine9LRE-H4-Histamine-Gi1/β1/γ2
11.54Consensus5ht2_onOrthosteric Ligand5ht2b_on
11.54Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.54Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
11.54Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
11.43Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
11.43Single4IARErgotamine4IAR-5-HT1B-Ergotamine
11.43Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
11.43Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
11.43Single7F8XNN90567F8X-CCKA-NN9056
11.43Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
11.43Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
11.43Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
11.43Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
11.43Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
11.43Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
11.43Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
11.43Single8IEBA1LYA8IEB-GPR156-A1LYA
11.43Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
11.43Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.43Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
11.43Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
11.43Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
11.43Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
11.43Single9M4TSilodosin9M4T-Alpha1A-Silodosin
11.43Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
11.43Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
11.43Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
11.43Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
11.11Single4O9RCyclopamine4O9R-SMO-Cyclopamine
11.11Single6HLOAprepitant6HLO-NK1-Aprepitant
11.11Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
11.11Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
11.11Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
11.11Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
11.11Single7SK5CXCL127SK5-ACKR3-CXCL12
11.11Single7SRQLSD7SRQ-5-HT2B-LSD
11.11Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
11.11Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
11.11Single7V68Iperoxo7V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
11.11Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
11.11Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
11.11Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
11.11Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
11.11Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
11.11Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
11.11Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
11.11Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
11.11Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
11.11Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
11.11Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
11.11Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
11.11Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
11.11Single8YKDDehydroepiandrosterone8YKD-ADGRG2-Dehydroepiandrosterone-chim(NtGi1-Gs)/β1/γ2
11.11Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
11.11Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
11.11Single8YN7Immethridine8YN7-H3-Immethridine-Go/β1/γ2
11.11Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
11.11Single8ZYUNeurotensin peptide 8-138ZYU-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
11.11Single9AS2DMT9AS2-5-HT2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
11.11Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
11.11Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
11.11Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
11.11Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
11.11Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
11.11Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
11.11Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
11.11Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
11.11Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
10.81Single3OE0CVX153OE0-CXCR4-CVX15
10.81Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
10.81Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.81Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
10.71Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
10.71Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
10.71Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
10.71Single3ODUIT1t3ODU-CXCR4-IT1t
10.71Single3PWHZM-2413853PWH-A2A-ZM-241385
10.71Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
10.71Single4QINSAG1.54QIN-SMO-SAG1.5
10.71Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
10.71Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
10.71Single6B73MP11046B73-κ-MP1104
10.71Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
10.71Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
10.71Single6ME9Ramelteon6ME9-MT2-Ramelteon
10.71Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
10.71Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
10.71Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
10.71Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
10.71Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
10.71Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
10.71Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.71Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
10.71Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
10.71Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
10.71Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
10.71Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
10.71Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
10.71Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
10.71Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.71Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
10.71Single8GNGIstradefylline8GNG-A2A-Istradefylline
10.71Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
10.71Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
10.71Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
10.71Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
10.71Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
10.71Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
10.71Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
10.71Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
10.71Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.71Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.71Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.71Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
10.71Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
10.71Single8Y0HVUF114188Y0H-CXCR3-VUF11418
10.71Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go/β1/γ2
10.71Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ2
10.71Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
10.71Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
10.71Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
10.71Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
10.71Single9H2XA1IR19H2X-A2A-A1IR1-Na
10.71Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
10.71Single9KPESA09KPE-TAS2R16-SA0-Gi1/β1/γ2
10.71Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
10.71Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
10.71Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
10.71Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.71Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
10.71Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
10.71Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
10.71Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
10.71Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
10.71Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
10.71Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
10.71Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
10.71Consensusorexin_offOrthosteric Ligandox2_off ox1_off
10.71Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
10.71Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
10.71Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
10.53Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
10.53Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
10.53Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
10.34Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
10.34Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
10.34Single4ZJCSB-6740424ZJC-OX1-SB-674042
10.34Single5UVIZM-2413855UVI-A2A-ZM-241385
10.34Single6A94Zotepine6A94-5-HT2A-Zotepine
10.34Single6AQFZM-2413856AQF-A2A-ZM-241385
10.34Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
10.34Single6KUXRS-799486KUX-α2a-RS-79948
10.34Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
10.34Single6MH8ZM-2413856MH8-A2A-ZM-241385
10.34Single6TPGEMPA6TPG-OX2-EMPA
10.34Single6V9SGTPL114036V9S-OX1-GTPL11403
10.34Single6VI4JDTic6VI4-κ-JDTic
10.34Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
10.34Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
10.34Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
10.34Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
10.34Single6ZG9GSK10347026ZG9-M1-GSK1034702
10.34Single7AROLUF58337ARO-A2A-LUF5833-Na
10.34Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
10.34Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
10.34Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
10.34Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
10.34Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
10.34Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
10.34Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
10.34Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.34Single7T94Acetylcholine7T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
10.34Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
10.34Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
10.34Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
10.34Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
10.34Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
10.34Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
10.34Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
10.34Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
10.34Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
10.34Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
10.34Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.34Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
10.34Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
10.34Single8K9LDamgo8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
10.34Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
10.34Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
10.34Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.34Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.34Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.34Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.34Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
10.34Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
10.34Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
10.34Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
10.34Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
10.34Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
10.34Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Single8ZPMAMD0708ZPM-CXCR4-AMD070
10.34Single9AS3LSD9AS3-5-HT2A-LSD
10.34Single9AS4LSD9AS4-5-HT2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
10.34Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
10.34Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
10.34Consensusalpha1_onOrthosteric Ligandalpha1a_on
10.34Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
10.34Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
10.34Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
10.34Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
10.34Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
10.34Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
10.34Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
10.34Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
10.34Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
10.34Consensusopsins_offOrthosteric Ligandrhodopsin_off
10.34Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
10.34Consensussensory_offOrthosteric Ligandopsins_off
10.26Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
10.00Single2Y01Dobutamine2Y01-β1-Dobutamine
10.00Single2Y02Carmoterol2Y02-β1-Carmoterol
10.00Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
10.00Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
10.00Single4DAJTiotropium4DAJ-M3-Tiotropium
10.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
10.00Single4MQSIperoxo4MQS-M2-Iperoxo
10.00Single4QIMANTA XV4QIM-SMO-ANTA XV
10.00Single4U14Tiotropium4U14-M3-Tiotropium
10.00Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
10.00Single5DHGC-355DHG-NOP-C-35
10.00Single5DSGTiotropium5DSG-M4-Tiotropium
10.00Single5TGZAM65385TGZ-CB1-AM6538
10.00Single5UIGCmpd-15UIG-A2A-Cmpd-1
10.00Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
10.00Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
10.00Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
10.00Single6DRXLisuride6DRX-5-HT2B-Lisuride
10.00Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
10.00Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
10.00Single6TOTLemborexant6TOT-OX1-Lemborexant
10.00Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
10.00Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
10.00Single7BU7BI1671077BU7-β1-BI167107
10.00Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
10.00Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
10.00Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
10.00Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
10.00Single7SK3CXCL127SK3-ACKR3-CXCL12
10.00Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
10.00Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
10.00Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
10.00Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
10.00Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
10.00Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
10.00Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
10.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
10.00Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
10.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
10.00Single8CU6LJ-45178CU6-A2A-LJ-4517
10.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
10.00Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
10.00Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
10.00Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
10.00Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
10.00Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
10.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
10.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
10.00Single8JXRLSD8JXR-D1-LSD
10.00Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
10.00Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
10.00Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
10.00Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
10.00Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
10.00Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
10.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
10.00Single8X63Mepyramine8X63-H1-Mepyramine
10.00Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
10.00Single8YN8Proxyfan8YN8-H3-Proxyfan-Go/β1/γ2
10.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
10.00Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
10.00Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
10.00Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
10.00Single9IYAONO-97105319IYA-GPR55-ONO-9710531
10.00Single9JEAAtropine9JEA-M1-Atropine
10.00Single9JGKBalovaptan9JGK-5-HT2B-Balovaptan
10.00Single9PLNN-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLN-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine
10.00Single9PLON-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLO-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine-Go/β1/γ2
10.00Single9PQD(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole9PQD-α2a-(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole
10.00Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
10.00Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
10.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
10.00Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
10.00Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
10.00Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
10.00Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
10.00Consensusalpha2_onOrthosteric Ligandalpha2b_on
10.00Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
10.00Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
10.00Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
10.00Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
10.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
10.00Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
10.00Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
10.00Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
10.00Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
10.00Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
10.00Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
10.00Consensushistamine_offOrthosteric Ligandh1_off
10.00Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
10.00Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
10.00Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
10.00Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
9.76Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
9.76Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
9.76Single9KDFRES-701-39KDF-ETB-RES-701-3
9.68Single2Y00Dobutamine2Y00-β1-Dobutamine
9.68Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
9.68Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
9.68Single5WQCEMPA5WQC-OX2-EMPA
9.68Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
9.68Single6LUQHaloperidol6LUQ-D2-Haloperidol
9.68Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
9.68Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
9.68Single6TP6Filorexant6TP6-OX1-Filorexant
9.68Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
9.68Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
9.68Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
9.68Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
9.68Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
9.68Single7W41PD1762527W41-BB2-PD176252
9.68Single7WC6LSD7WC6-5-HT2A-LSD
9.68Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
9.68Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.68Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
9.68Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
9.68Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
9.68Single8ZMFA1L108ZMF-5-HT2C-A1L10
9.68Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Single9ARZ2-bromo-LSD9ARZ-5-HT2A-2-bromo-LSD
9.68Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
9.68Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
9.68Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Single9DYDAsenapine9DYD-5-HT1A-Asenapine-Go/β1/γ2
9.68Single9DYFAsenapine9DYF-5-HT1A-Asenapine-Gi1/β1/γ2
9.68Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
9.68Single9F34FOB02-04A9F34-D3-FOB02-04A-Go/β1/γ2
9.68Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
9.68Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
9.68Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
9.68Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
9.68Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
9.68Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
9.68Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
9.68Consensusblt_offOrthosteric Ligandblt1_off
9.68Consensusbombesin_offOrthosteric Ligandbb2_off
9.68Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
9.68Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
9.68Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
9.68Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
9.68Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
9.68Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
9.68Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
9.68Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.68Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.38Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
9.38Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
9.38Single4U15Tiotropium4U15-M3-Tiotropium
9.38Single5V54Methiothepin5V54-5-HT1B-Methiothepin
9.38Single6J20Aprepitant6J20-NK1-Aprepitant
9.38Single6OL9Tiotropium6OL9-M5-Tiotropium
9.38Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
9.38Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
9.38Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
9.38Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
9.38Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
9.38Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
9.38Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
9.38Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
9.38Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
9.38Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.38Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
9.38Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
9.38Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
9.38Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
9.38Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
9.38Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
9.38Single9BJKNaloxone9BJK-μ-Naloxone-NAM
9.38Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
9.38Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38Consensus5ht1_offOrthosteric Ligand5ht1b_off
9.38Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
9.38Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
9.38Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
9.38Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
9.38Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
9.38Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
9.38Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
9.38Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
9.38Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
9.09Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
9.09Single4RWADIPP-NH24RWA-δ-DIPP-NH2
9.09Single5CXVTiotropium5CXV-M1-Tiotropium
9.09Single7K15MKD0467K15-BLT1-MKD046-Na
9.09Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
9.09Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
9.09Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
9.09Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.09Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
9.09Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
9.09Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
9.09Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single8XWMCXCL68XWM-CXCR2-CXCL6
9.09Single8XWSCXCL58XWS-CXCR2-CXCL5
9.09Single9BJKNAM9BJK-μ-Naloxone-NAM
9.09Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
9.09Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
9.09Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
9.09Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
9.09Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
9.09Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
9.09Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.09Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.82Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
8.82Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
8.82Single6K1QIRL25006K1Q-ETB-IRL2500
8.82Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
8.82Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.82Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
8.82Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
8.82Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
8.82Single8XVJMacitentan8XVJ-ETA-Macitentan
8.82Single8XWFCXCL38XWF-CXCR2-CXCL3
8.82Single8ZPLHF511168ZPL-CXCR4-HF51116
8.82Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
8.70Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
8.57Single6PT3DPI-2876PT3-δ-DPI-287
8.57Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
8.57Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
8.57Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.57Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
8.57Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
8.57Single8XQJJN2418XQJ-Apelin-JN241
8.57Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
8.57Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
8.57Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
8.57Single9JF4PD1683689JF4-BB1-PD168368
8.57Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
8.57Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
8.33Single5MZPCaffeine5MZP-A2A-Caffeine-Na
8.33Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Single8IEIA1LYA8IEI-GPR156-A1LYA
8.33Single8IEIA1LYA8IEI-GPR156-A1LYA
8.33Single8IEPA1LYA8IEP-GPR156-A1LYA
8.33Single8IEPA1LYA8IEP-GPR156-A1LYA
8.33Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
8.33Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
8.33Single8KIGSHU91198KIG-MC3-SHU9119-Ca
8.33Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
8.33Single8WKYPG-9348WKY-MC4-PG-934
8.33Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
8.33Single8XWNCXCL88XWN-CXCR2-CXCL8
8.33Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
8.33Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
8.11Single8IEBA1LYA8IEB-GPR156-A1LYA
8.11Single9IK8SST analogue9IK8-SST1-SST analogue-Gi1/β1/γ2
8.11Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
8.11Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
8.00Single6VCBLSN31604406VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
8.00Single7V68LY21196207V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
8.00Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
8.00Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
7.89Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
7.89Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
7.89Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
7.89Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
7.89Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
7.69Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
7.69Single3OE8IT1t3OE8-CXCR4-IT1t
7.69Single3RFMCaffeine3RFM-A2A-Caffeine
7.69Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
7.69Single6TQ9SB-4081246TQ9-OX1-SB-408124
7.69Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
7.69Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
7.69Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
7.69Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
7.69Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
7.69Single8Y02Retinal8Y02-OPN1SW-Retinal-Gi1/β1/γ2
7.69Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
7.69Single9IVMLSN33188399IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
7.69Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
7.69Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
7.50Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
7.50Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
7.41Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
7.41Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
7.41Single3UZAGTPL92363UZA-A2A-GTPL9236
7.41Single4XNWMRS25004XNW-P2Y1-MRS2500
7.41Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
7.41Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
7.41Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
7.41Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
7.41Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
7.41Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
7.41Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.41Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
7.41Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
7.41Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
7.41Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
7.41Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
7.41Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
7.41Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
7.41Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
7.41Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
7.41Consensusgi_sensoryOrthosteric Ligandgi_opsins
7.41Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
7.41Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
7.41Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
7.41Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
7.14Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
7.14Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
7.14Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
7.14Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
7.14Single3PBLEticlopride3PBL-D3-Eticlopride
7.14Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
7.14Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
7.14Single6HLLCP999946HLL-NK1-CP99994
7.14Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
7.14Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
7.14Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
7.14Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
7.14Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
7.14Single7UL2SR486927UL2-NTS1-SR48692-Na
7.14Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
7.14Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
7.14Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
7.14Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
7.14Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
7.14Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
7.14Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
7.14Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
7.14Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.14Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.14Single9AS7Psilocin9AS7-5-HT2A-Psilocin
7.14Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
7.14Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.14Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
7.14Single9IXJHistamine9IXJ-H2-Histamine-Gs/β1/γ2
7.14Single9IZDCHBA9IZD-HCA1-CHBA-Gi1/β1/γ2
7.14Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
7.14Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
7.14Consensusgq_nucleotideOrthosteric Ligandgq_p2y
7.14Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
7.14Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
7.14Consensusneurotensin_offOrthosteric Ligandnts1_off
7.14Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
6.90Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
6.90Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
6.90Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
6.90Single4S0VSuvorexant4S0V-OX2-Suvorexant
6.90Single5WS3EMPA5WS3-OX2-EMPA
6.90Single6DS0Ly2660976DS0-5-HT2B-Ly266097
6.90Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
6.90Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
6.90Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
6.90Single6TODEMPA6TOD-OX1-EMPA-Na
6.90Single6TPJSuvorexant6TPJ-OX2-Suvorexant
6.90Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
6.90Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
6.90Single7F8ULintitript7F8U-CCKA-Lintitript
6.90Single7F8YDevazepide7F8Y-CCKA-Devazepide
6.90Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
6.90Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.90Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
6.90Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
6.90Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
6.90Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
6.90Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
6.90Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
6.90Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
6.90Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
6.90Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
6.90Single7XRRLemborexant7XRR-OX2-Lemborexant
6.90Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
6.90Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
6.90Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
6.90Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.90Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
6.90Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
6.90Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
6.90Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
6.90Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
6.90Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
6.90Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
6.90Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
6.90Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
6.90Single9LRBHistamine9LRB-H1-Histamine-Gs/β1/γ2
6.90Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
6.90Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
6.90Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
6.90Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
6.90Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
6.90Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
6.90Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
6.67Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
6.67Single3REYXAC3REY-A2A-XAC
6.67Single3RZECidoxepin3RZE-H1-Cidoxepin
6.67Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
6.67Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
6.67Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
6.67Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
6.67Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
6.67Single6IQLL7458706IQL-D4-L745870
6.67Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
6.67Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
6.67Single6TP3Nemorexant6TP3-OX1-Nemorexant
6.67Single6TPNHTL66416TPN-OX2-HTL6641
6.67Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
6.67Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
6.67Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
6.67Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
6.67Single7VODCariprazine7VOD-5-HT2A-Cariprazine
6.67Single7VV6C48/807VV6-MRGPRX2-C48/80
6.67Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
6.67Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
6.67Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
6.67Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
6.67Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.67Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
6.67Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
6.67Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
6.67Single8ZPNAMD31008ZPN-CXCR4-AMD3100
6.67Single9ARXSerotonin9ARX-5-HT2A-Serotonin
6.67Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
6.67Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
6.67Single9LRDHistamine9LRD-H1-Histamine-Gi1/β1/γ2
6.67Consensusgrh_offOrthosteric Ligandgnrh1_off
6.45Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
6.45Single6D27CAY104716D27-DP2-CAY10471
6.45Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
6.45Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
6.45Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
6.45Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.45Single7F83PF-051904577F83-Ghrelin-PF-05190457
6.45Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
6.45Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
6.45Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
6.45Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.45Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
6.45Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
6.45Single8X64Desloratadine8X64-H1-Desloratadine
6.45Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
6.45Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
6.45Consensuscck_offOrthosteric Ligandccka_off
6.45Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
6.45Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
6.25Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
6.25Single5CGCHTL142425CGC-mGlu5-HTL14242
6.25Single5XPRBosentan5XPR-ETB-Bosentan
6.25Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
6.25Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
6.25Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
6.25Single7SINNPS-21437SIN-CaS-NPS-2143
6.25Single7SINNPS-21437SIN-CaS-NPS-2143
6.25Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.25Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
6.25Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
6.25Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
6.25Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
6.25Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
6.25Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
6.25Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
6.25Single9HAPTolvaptan9HAP-V2-Tolvaptan
6.25Single9HC04YI9HC0-mGlu5-4YI
6.25Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
6.25Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
6.25Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
6.06Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
6.06Single5TZRMK86665TZR-FFA1-MK8666
6.06Single6E59L-7607356E59-NK1-L-760735
6.06Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
6.06Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
6.06Single7P2L4YI7P2L-mGlu5-4YI
6.06Single7R0CAVP7R0C-V2-AVP-Arrestin2
6.06Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
6.06Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
6.06Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
6.06Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
6.06Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
6.06Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
6.06Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
6.06Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
6.06Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
6.06Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
6.06Single8XVLZibotentan8XVL-ETA-Zibotentan
6.06Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
6.06Single9AS9RS130-1809AS9-5-HT2A-RS130-180
6.06Single9ASARS130-1809ASA-5-HT2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
6.06Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
6.06Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
6.06Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
6.06Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
6.06Consensustachykinin_offOrthosteric Ligandnk1_off
5.88Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
5.88Single4PY02MeSATP4PY0-P2Y12-2MeSATP
5.88Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
5.88Single5X33BIIL2605X33-BLT1-BIIL260
5.88Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
5.88Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
5.88Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
5.88Single8XQJJN2418XQJ-Apelin-JN241
5.88Single8XWACXCL18XWA-CXCR2-CXCL1
5.88Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
5.88Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
5.71Single5CGDHTL142425CGD-mGlu5-HTL14242
5.71Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
5.71Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
5.71Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.71Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
5.71Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
5.71Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
5.56Single6KNMJN241-96KNM-Apelin-JN241-9
5.56Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
5.56Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
5.56Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
5.41Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
5.41Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
5.41Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.41Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
5.41Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.41Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.26Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
5.26Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
5.13Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
5.13Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
5.00Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
4.35Consensusclass-b2_onOrthosteric Ligandadgrg_on adgrf_on adgrl_on adgre_on adgrd_on
4.35Consensusclass-b2_on_gpOrthosteric Ligandadgrg_on_gp adgrf_on_gp adgrl_on_gp adgre_on_gp adgrd_on_gp
4.17Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
4.00Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single7WC4Serotonin7WC4-5-HT2A-Serotonin
3.70Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.70Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
3.70Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
3.70Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
3.70Consensusp2y_offOrthosteric Ligandp2y1_off
3.70Consensussensory_onOrthosteric Ligandopsins_on
3.57Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
3.57Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
3.57Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
3.57Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
3.57Single7WC5Psilocin7WC5-5-HT2A-Psilocin
3.57Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.57Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
3.57Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
3.57Single8JPSCCL78JPS-ACKR1-CCL7
3.57Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
3.57Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
3.57Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
3.57Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
3.57Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
3.57Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
3.45Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
3.45Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
3.45Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.45Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
3.45Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.45Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
3.45Single8HNNSCH5467388HNN-CXCR3-SCH546738
3.45Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
3.33Single7BR3Elagolix7BR3-GnRH1-Elagolix
3.33Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
3.33Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
3.33Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
3.33Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
3.33Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.33Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.33Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
3.23Single6FFIMMPEP6FFI-mGlu5-MMPEP
3.23Single6TPKRetosiban6TPK-OT-Retosiban
3.23Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23Single8IYXYL-3658IYX-GPR34-YL-365
3.23Single8JD6VU03647708JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
3.23Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
3.23Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23Single9IXXLTD49IXX-CysLT2-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
3.23Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
3.23Consensusvasop-oxy_offOrthosteric Ligandot_off
3.12Single6FFHFenobam6FFH-mGlu5-Fenobam
3.12Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
3.12Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
3.03Single4NTJAZD12834NTJ-P2Y12-AZD1283
3.03Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
3.03Single6HLPNetupitant6HLP-NK1-Netupitant
3.03Single6Z4SSR486926Z4S-NTS1-SR48692
3.03Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
3.03Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
3.03Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
3.03Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
2.94Single9CLWTUG-13759CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.94Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
2.86Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
2.86Single9CM3TUG-13759CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.86Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
2.86Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
2.78Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
2.70Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
2.70Single9NS9TUG-13759NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
2.56Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2

PDB Summary
PDB 7CZ5
Class B1
SubFamily Peptide
Type Glucagon
SubType GHRH
Species Homo Sapiens
Ligand Somatoliberin
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 2.6
Date 2020-11-18
D.O.I. doi.org/10.1038/s41467-020-18945-0
Net Summary
Imin 2.66
Number of Linked Nodes 860
Number of Links 1113
Number of Hubs 216
Number of Links mediated by Hubs 755
Number of Communities 23
Number of Nodes involved in Communities 300
Number of Links involved in Communities 456
Path Summary
Number Of Nodes in MetaPath 98
Number Of Links MetaPath 97
Number of Shortest Paths 2352396
Length Of Smallest Path 3
Average Path Length 28.8735
Length of Longest Path 57
Minimum Path Strength 1.07
Average Path Strength 6.88683
Maximum Path Strength 23.1
Minimum Path Correlation 0.7
Average Path Correlation 0.986372
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.22581
Average % Of Corr. Nodes 42.5537
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 55.2072
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • cation binding   • metal ion binding   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development
Gene OntologyBiological Process• developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • cellular response to stimulus   • cellular response to nitrogen compound   • response to stimulus   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • cellular process   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • biological regulation   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • regulation of biological process   • regulation of cellular process   • signaling   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • positive regulation of cellular process   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • localization   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of signaling   • regulation of transport   • secretion   • regulation of hormone levels   • regulation of peptide transport   • regulation of establishment of protein localization   • establishment of protein localization to extracellular region   • export from cell   • cell-cell signaling   • regulation of protein transport   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • cellular localization   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • intracellular anatomical structure   • cytoplasm   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • trans-Golgi network   • organelle membrane   • hormone activity   • growth hormone-releasing hormone activity   • protein binding   • binding   • molecular function activator activity   • signaling receptor binding   • molecular function regulator activity   • signaling receptor regulator activity   • receptor ligand activity   • signaling receptor activator activity   • growth hormone-releasing hormone receptor binding   • G protein-coupled receptor binding   • neuropeptide receptor binding   • neuropeptide activity   • neuropeptide hormone activity   • peptide hormone receptor binding   • hormone receptor binding   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • cell population proliferation   • positive regulation of cell population proliferation   • regulation of cell population proliferation   • positive regulation of biological process   • positive regulation of cellular process   • developmental process   • multicellular organismal process   • head development   • forebrain development   • endocrine system development   • pituitary gland development   • gland development   • animal organ development   • brain development   • diencephalon development   • nervous system development   • multicellular organism development   • central nervous system development   • anatomical structure development   • adenohypophysis development   • system development   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of signal transduction   • cell surface receptor protein tyrosine kinase signaling pathway   • positive regulation of response to stimulus   • positive regulation of insulin-like growth factor receptor signaling pathway   • regulation of insulin-like growth factor receptor signaling pathway   • enzyme-linked receptor protein signaling pathway   • regulation of signaling   • cell surface receptor signaling pathway   • insulin-like growth factor receptor signaling pathway   • regulation of response to stimulus   • regulation of cell communication   • positive regulation of signaling   • regulation of localization   • localization   • regulation of protein localization   • macromolecule localization   • intracellular protein localization   • regulation of multicellular organism growth   • regulation of growth   • regulation of developmental growth   • regulation of developmental process   • developmental growth   • growth   • positive regulation of multicellular organism growth   • positive regulation of developmental process   • multicellular organism growth   • positive regulation of growth   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • positive regulation of developmental growth   • cell-cell signaling   • nitrogen compound transport   • transport   • hormone secretion   • peptide secretion   • secretion by cell   • amide transport   • signal release   • regulation of biological quality   • growth hormone secretion   • secretion   • regulation of hormone levels   • export from cell   • establishment of localization   • peptide transport   • peptide hormone secretion   • hormone transport   • regulation of circadian sleep/wake cycle   • regulation of circadian rhythm   • regulation of behavior   • sleep   • rhythmic process   • circadian sleep/wake cycle, sleep   • circadian sleep/wake cycle   • rhythmic behavior   • circadian rhythm   • regulation of circadian sleep/wake cycle, REM sleep   • behavior   • circadian behavior   • circadian sleep/wake cycle, REM sleep   • positive regulation of behavior   • positive regulation of circadian rhythm   • positive regulation of circadian sleep/wake cycle, REM sleep   • positive regulation of circadian sleep/wake cycle, sleep   • regulation of circadian sleep/wake cycle, sleep   • circadian sleep/wake cycle process   • regulation of hormone secretion   • regulation of peptide secretion   • positive regulation of secretion by cell   • regulation of secretion by cell   • positive regulation of hormone secretion   • positive regulation of secretion   • regulation of peptide hormone secretion   • positive regulation of peptide secretion   • regulation of transport   • regulation of growth hormone secretion   • regulation of peptide transport   • positive regulation of peptide hormone secretion   • regulation of secretion   • positive regulation of growth hormone secretion   • positive regulation of transport   • response to nutrient levels   • response to food   • response to chemical   • somatodendritic compartment   • cell body   • perikaryon   • neuronal cell body   • axon   • synapse   • neuron projection   • axon terminus   • plasma membrane bounded cell projection   • presynapse   • cell projection   • distal axon   • terminal bouton   • cell junction   • neuron projection terminus   • G-protein beta-subunit binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to oxygen-containing compound   • response to nitrogen compound   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • cytoskeletal protein binding   • spectrin binding   • protein-containing complex binding   • enzyme binding   • GTPase binding   • phosphoric ester hydrolase activity   • alkylglycerophosphoethanolamine phosphodiesterase activity   • hydrolase activity, acting on ester bonds   • phosphoric diester hydrolase activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • positive regulation of cytosolic calcium ion concentration   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • sensory organ development   • eye development   • retina development in camera-type eye   • visual system development   • camera-type eye development   • sensory system development   • response to decreased oxygen levels   • cellular response to oxygen levels   • cellular response to hypoxia   • cellular response to decreased oxygen levels   • cellular response to stress   • response to hypoxia   • response to stress   • response to oxygen levels   • response to abiotic stimulus   • phospholipase C-activating G protein-coupled receptor signaling pathway   • muscle cell apoptotic process   • striated muscle cell apoptotic process   • apoptotic process   • cell death   • programmed cell death   • cardiac muscle cell apoptotic process   • photoreceptor inner segment   • dendrite   • dendritic tree   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • photoreceptor outer segment   • photoreceptor cell cilium   • ciliary membrane   • photoreceptor outer segment membrane   • bounding membrane of organelle   • plasma membrane region   • cell projection membrane   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • growth factor binding   • growth hormone-releasing hormone receptor activity   • amide binding   • peptide hormone binding   • hormone binding   • peptide receptor activity   • G protein-coupled peptide receptor activity   • response to estrogen   • homeostatic process   • cellular response to glucose stimulus   • intracellular glucose homeostasis   • response to hexose   • cellular response to carbohydrate stimulus   • cellular homeostasis   • response to monosaccharide   • response to carbohydrate   • chemical homeostasis   • response to glucose   • glucose homeostasis   • carbohydrate homeostasis   • cellular response to hexose stimulus   • intracellular chemical homeostasis   • cellular response to monosaccharide stimulus   • metabolic process   • hormone metabolic process   • regulation of circadian sleep/wake cycle, non-REM sleep   • circadian sleep/wake cycle, non-REM sleep   • positive regulation of circadian sleep/wake cycle, non-REM sleep   • reproductive process   • multicellular organismal reproductive process   • response to corticosteroid   • response to steroid hormone   • response to glucocorticoid   • cellular developmental process   • anatomical structure maturation   • cell differentiation   • cell development   • cell maturation   • developmental maturation   • cellular localization   • establishment of localization in cell   • determination of adult lifespan   • intracellular signal transduction   • cAMP/PKA signal transduction   • intracellular signaling cassette   • response to peptide hormone   • response to insulin   • regulation of body fluid levels   • mammary gland development   • body fluid secretion   • lactation   • cellular response to peptide hormone stimulus   • cellular response to insulin stimulus   • somatotropin secreting cell differentiation   • somatotropin secreting cell development   • intracellular receptor signaling pathway   • hormone-mediated signaling pathway   • regulation of intracellular signal transduction   • regulation of intracellular steroid hormone receptor signaling pathway   • nuclear receptor-mediated steroid hormone signaling pathway   • cellular response to steroid hormone stimulus   • steroid hormone receptor signaling pathway   • nuclear receptor-mediated signaling pathway   • regulation of protein metabolic process   • primary metabolic process   • regulation of macromolecule metabolic process   • regulation of primary metabolic process   • protein metabolic process   • macromolecule metabolic process   • regulation of metabolic process   • nucleus   • membrane-enclosed lumen   • intracellular organelle lumen   • organelle lumen   • nuclear lumen   • nuclear matrix   • cell surface   • sarcolemma   • intracellular vesicle   • cytoplasmic vesicle   • secretory granule   • secretory vesicle   • nuclear outer membrane   • nuclear membrane   • organelle outer membrane   • organelle envelope   • nuclear outer membrane-endoplasmic reticulum membrane network   • nuclear envelope   • outer membrane   • organelle inner membrane   • nuclear inner membrane
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7CZ5_Chain_A
TEDQRNEEK AQREANKKI EKQLQKDKQ VYRATHRLL LLGAGESGK 
NTIVKQMSG IFETKFQVD KVNFHMFDV GAQRDERRK WIQCFNDVT 
AIIFVVASS TNRLQAALK LFDSIWNNK WLRDTSVIL FLNKQDLLA 
EKVLAKIED YFPEFARYT TPEDATPEP GEDPRVTRA KYFIRDEFL 
RISTASGDG RHYCYPHFT CAVDTENIR RVFNDCRDI IQRMHLRQY 
ELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP54311
Sequence
>7CZ5_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP63212
Sequence
>7CZ5_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ02643
Sequence
>7CZ5_Chain_R
LAEEESYFS TVKIIYTVG HSISIVALF VAITILVAL RRLHCPRNY 
VHTQLFTTF ILKAGAVFL KDAALFHSD DTDHCSFST VLCKVSVAA 
SHFATMTNF SWLLAEAVY LNCLLASTS PSSRRAFWW LVLAGWGLP 
VLFTGTWVS CKLAFEDIA CWDLDDTSP YWWIIKGPI VLSVGVNFG 
LFLNIIRIL VRKLETQSQ YWRLSKSTL FLIPLFGIH YIIFNFLPD 
NAGLGIRLP LELGLGSFQ GFIVAILYC FLNQEVRTE ISRKWHGH


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7CZ5B1PeptideGlucagonGHRHHomo sapiensSomatoliberin-Gs/β1/γ22.62020-11-18doi.org/10.1038/s41467-020-18945-0
7CZ5 (No Gprot) B1PeptideGlucagonGHRHHomo sapiensSomatoliberin-2.62020-11-18doi.org/10.1038/s41467-020-18945-0
7V9MB1PeptideGlucagonGHRH (SV1)Homo sapiensSomatoliberin-Gs/β1/γ23.292021-10-20doi.org/10.1073/pnas.2106606118
7V9M (No Gprot) B1PeptideGlucagonGHRH (SV1)Homo sapiensSomatoliberin-3.292021-10-20doi.org/10.1073/pnas.2106606118
7V9LB1PeptideGlucagonGHRH (SV1)Homo sapiens--chim(NtGi1-Gs)/β1/γ22.62022-04-06doi.org/10.1073/pnas.2106606118
7V9L (No Gprot) B1PeptideGlucagonGHRH (SV1)Homo sapiens--2.62022-04-06doi.org/10.1073/pnas.2106606118




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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