Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L5 2.8525402
2A:A:K34 4.625404
3A:A:H41 7.15106
4A:A:L46 5.824228
5A:A:N50 7.614599
6A:A:S51 4.155409
7A:A:K53 6.065409
8A:A:Y63 7.865409
9A:A:F219 8.386676108
10A:A:R232 8.5775438
11A:A:K233 6.11167639
12A:A:W234 8.08639
13A:A:C237 6.1438
14A:A:F238 11.105409
15A:A:D249 10.3125498
16A:A:S251 4.12499
17A:A:Y253 9.48754248
18A:A:R265 9.2175499
19A:A:F273 5.628336169
20A:A:W277 8.546676166
21A:A:W281 10.30176155
22A:A:I288 8.32254199
23A:A:L291 5.8408
24A:A:F312 5.182508
25A:A:F315 14.6125406
26A:A:P321 3.2275405
27A:A:E330 7.2125463
28A:A:V334 3.5275404
29A:A:K338 10.5425465
30A:A:Y339 7.4975463
31A:A:F340 10.39507
32A:A:R342 8.026564
33A:A:F345 9.3825408
34A:A:Y360 7.635408
35A:A:F363 11.134565
36A:A:R374 10.16754264
37A:A:I375 5.95254199
38A:A:F376 6.288577108
39A:A:H387 6.745408
40A:A:Y391 9.5625444
41R:R:H73 6.9925277
42R:R:L87 5.465407
43R:R:L90 3.65546
44R:R:R92 7.5425446
45R:R:L93 5.5625449
46R:R:R97 9.10286749
47R:R:N98 6.775448
48R:R:H101 8.665449
49R:R:F105 4.8225407
50R:R:T107 6.0175408
51R:R:F108 10.036507
52R:R:L122 3.4065296
53R:R:F123 3.0175404
54R:R:H146 9.0425457
55R:R:F147 5.81408
56R:R:T151 6.7775408
57R:R:F153 9.53408
58R:R:W155 11.776209
59R:R:E159 10.2675449
60R:R:L167 5.1925408
61R:R:F192 6.6825455
62R:R:W196 9.285458
63R:R:W209 10.4333658
64R:R:Y217 10.945403
65R:R:W218 10.3875456
66R:R:I221 8.985457
67R:R:F236 8.575178
68R:R:K246 6.2145258
69R:R:F274 8.0825178
70R:R:Y278 11.014288
71R:R:F281 6.07607
72R:R:Q304 7.9854289
73R:R:Y312 10.6275409
74R:R:C313 4.585409
75R:R:N316 7.94449
76G:G:I9 3.5975402
77G:G:L19 3.675309
78G:G:R27 8.8175418
79G:G:Y40 10.454186
80G:G:D48 6.835409
81G:G:L51 4.152576
82G:G:N59 7.3075429
83G:G:P60 8.1825429
84G:G:F61 7.022528
85B:B:L4 3.6425404
86B:B:I37 4.705672
87B:B:V40 6.1175473
88B:B:H54 9.656529
89B:B:W63 7.898527
90B:B:L70 6.7025425
91B:B:V71 6.03254118
92B:B:S72 5.426529
93B:B:Q75 10.01439
94B:B:D76 7.8325409
95B:B:L79 4.77254117
96B:B:I80 9.25428
97B:B:W82 10.9167629
98B:B:N88 7.0225407
99B:B:K89 6.382529
100B:B:H91 6.795405
101B:B:I93 7.16407
102B:B:L95 5.1085118
103B:B:W99 11.216509
104B:B:M101 6.715439
105B:B:Y105 5.901676116
106B:B:Y111 5.605404
107B:B:I123 5.105406
108B:B:Y124 6.1965116
109B:B:E130 8.0375403
110B:B:E138 7.4125406
111B:B:H142 8.4845129
112B:B:Y145 8.652538
113B:B:F151 6.14509
114B:B:L152 5.416323
115B:B:D163 7.4645129
116B:B:W169 11.6385128
117B:B:F180 9.128587
118B:B:H183 9.14689
119B:B:D186 6.986539
120B:B:F199 11.01489
121B:B:V200 7.596516
122B:B:C204 7.6375437
123B:B:D205 7.7489
124B:B:K209 10.236586
125B:B:L210 5.952505
126B:B:W211 9.38667688
127B:B:Q220 8.82417
128B:B:F222 11.4375418
129B:B:H225 9.71667619
130B:B:D228 8.452539
131B:B:I232 5.618518
132B:B:F234 5.846515
133B:B:F235 8.2645186
134B:B:P236 6.034187
135B:B:F241 9.11516
136B:B:T243 6.9825418
137B:B:D246 6.5375439
138B:B:D247 9.945419
139B:B:T249 7.1725416
140B:B:R251 11.14518
141B:B:F253 8.418516
142B:B:D254 7.675409
143B:B:R256 13.005409
144B:B:D258 10.8875417
145B:B:M262 7.7425404
146B:B:Y264 8.176505
147B:B:I269 3.94254134
148B:B:F278 5.623336187
149B:B:R283 8.09167679
150B:B:L285 4.6225406
151B:B:Y289 6.755717137
152B:B:D290 6.644156
153B:B:N295 9.0845136
154B:B:V296 3.915405
155B:B:D298 10.2025479
156B:B:L300 6.5625476
157B:B:V307 4.0845133
158B:B:H311 9.0945149
159B:B:R314 13.5285158
160B:B:W332 13.01176159
161B:B:L336 7.1075427
162B:B:K337 7.5585146
163B:B:I338 5.79425
164B:B:W339 12.88754149
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:M61 B:B:S72 14.0484.6NoYes269
2B:B:C317 B:B:M61 23.62179.73NoNo076
3B:B:C317 B:B:S316 23.93645.16NoNo079
4B:B:S316 B:B:W332 24.25094.94NoYes099
5A:A:W281 B:B:W332 15.2529.37YesYes1559
6A:A:N279 A:A:W281 60.02126.78NoYes085
7A:A:L282 A:A:N279 59.917413.73NoNo098
8A:A:I235 A:A:L282 30.6685.71NoNo099
9A:A:I235 A:A:W234 30.53857.05NoYes099
10A:A:Q227 A:A:W234 31.30498.76NoYes399
11A:A:Q227 B:B:N119 33.487411.88NoNo099
12B:B:G144 B:B:N119 33.03685.09NoNo089
13B:B:D163 B:B:G144 32.88645.03YesNo098
14B:B:D163 B:B:H142 32.27147.56YesYes1299
15B:B:H142 B:B:L146 18.03267.71YesNo1297
16B:B:G115 B:B:L146 18.45163.42NoNo097
17B:B:D118 B:B:G115 18.28393.35NoNo099
18B:B:D118 B:B:I120 17.94825.6NoNo096
19B:B:E138 B:B:I120 17.44376.83YesNo066
20B:B:K57 B:B:W332 10.154323.21NoYes099
21A:A:W281 B:B:D290 70.42147.82YesYes1556
22B:B:C271 B:B:D290 84.21634.67NoYes056
23B:B:C271 B:B:D291 84.30029.34NoNo058
24B:B:D291 B:B:Y289 84.21025.75NoYes087
25B:B:G288 B:B:Y289 99.93954.35NoYes077
26B:B:C294 B:B:G288 1003.92NoNo057
27B:B:C294 B:B:L308 49.95037.94NoNo057
28B:B:L308 B:B:W339 49.953723.92NoYes079
29B:B:K337 B:B:W339 49.90615.8YesYes1469
30B:B:K337 B:B:T50 99.99139.01YesNo063
31B:B:R52 B:B:T50 99.939810.35NoNo073
32B:B:R52 R:R:R91 99.887519.19NoNo077
33R:R:H94 R:R:R91 99.83594.51NoNo077
34R:R:H94 R:R:Y99 99.784110.89NoNo076
35R:R:F178 R:R:Y99 99.73217.22NoNo046
36R:R:F178 R:R:V182 99.62796.55NoNo044
37R:R:V182 R:R:W155 98.4927.36NoYes2049
38R:R:T107 R:R:W155 97.4646.06YesYes089
39R:R:L104 R:R:T107 48.51414.42NoYes098
40R:R:F108 R:R:L104 48.34957.31YesNo079
41R:R:F108 R:R:L80 77.82424.87YesNo078
42R:R:F105 R:R:L80 68.59596.09YesNo078
43R:R:F105 R:R:V308 48.07015.24YesNo079
44R:R:V308 R:R:Y312 47.85535.05NoYes099
45R:R:H101 R:R:Y312 40.78638.71YesYes099
46R:R:H101 R:R:R97 12.16014.51YesYes499
47A:A:Q390 R:R:R97 21.936214.02NoYes049
48A:A:H387 A:A:Q390 21.47236.18YesNo084
49A:A:H387 A:A:I383 15.43023.98YesNo088
50A:A:H41 A:A:I383 14.96455.3YesNo068
51B:B:R314 B:B:W332 13.475326.99YesYes1589
52B:B:D290 B:B:R314 13.630410.72YesYes1568
53B:B:C294 B:B:V315 50.11095.12NoNo057
54B:B:H311 B:B:V315 50.11444.15YesNo097
55B:B:H311 B:B:K337 50.132810.48YesYes1496
56R:R:N152 R:R:T107 48.51417.31NoYes088
57R:R:F108 R:R:N152 48.349516.92YesNo078
58R:R:C313 R:R:F105 19.95684.19YesYes097
59R:R:C313 R:R:L87 17.79836.35YesYes097
60R:R:L87 R:R:N98 14.46778.24YesYes078
61R:R:N98 R:R:R97 12.35448.44YesYes489
62A:A:Y391 R:R:H101 28.02335.44YesYes449
63A:A:Y391 R:R:L163 28.529112.89YesNo049
64R:R:L163 R:R:L167 28.06354.15NoYes098
65A:A:Q384 R:R:L167 12.75953.99NoYes068
66A:A:Q384 R:R:K246 12.52928.14NoYes068
67A:A:D381 R:R:K246 23.60136.91NoYes2588
68A:A:D381 A:A:Y360 23.144710.34NoYes088
69A:A:D378 A:A:Y360 21.77319.2NoYes078
70A:A:D378 A:A:I288 13.900516.79NoYes079
71R:R:I242 R:R:L167 13.21165.71NoYes078
72R:R:I242 R:R:K246 12.8644.36NoYes078
73A:A:L43 A:A:M221 11.1314.24NoNo078
74A:A:I276 A:A:L282 29.20184.28NoNo089
75A:A:I276 A:A:L46 29.07094.28NoYes088
76A:A:F363 A:A:L291 18.24167.31YesYes058
77A:A:F273 A:A:F345 18.32716.43YesYes098
78A:A:F246 A:A:F273 31.93175.36NoYes099
79A:A:F246 A:A:L46 32.06563.65NoYes098
80A:A:L289 A:A:L291 12.75066.92NoYes098
81R:R:I109 R:R:L80 10.69285.71NoNo068
82R:R:F81 R:R:I109 10.452410.05NoNo036
83R:R:F81 R:R:I77 10.21182.51NoNo036
84R:R:F108 R:R:Q304 20.237410.54YesYes079
85R:R:Q304 R:R:Y278 19.30844.51YesYes2898
86R:R:E297 R:R:Y278 15.28425.61NoYes078
87R:R:E297 R:R:R293 15.049220.93NoNo076
88R:R:D286 R:R:R293 12.69275.96NoNo046
89R:R:D286 R:R:K222 12.456412.44NoNo046
90R:R:K222 R:R:W218 11.98348.12NoYes066
91B:B:W297 B:B:Y289 22.46414.82NoYes1387
92B:B:W297 B:B:Y264 22.620510.61NoYes085
93B:B:L252 B:B:Y264 16.71177.03NoYes075
94B:B:L252 B:B:L261 15.18355.54NoNo075
95B:B:L261 G:G:V30 13.78654.47NoNo058
96B:B:Q259 G:G:V30 13.62955.73NoNo068
97B:B:Q259 B:B:R22 13.31497.01NoNo066
98B:B:H142 B:B:W169 15.09666.35YesYes1298
99B:B:L139 B:B:W169 14.483626.19NoYes098
100B:B:I123 B:B:L139 14.14015.71YesNo069
101B:B:I123 B:B:I171 12.41527.36YesNo066
102B:B:I157 B:B:I171 12.24215.89NoNo076
103B:B:C149 B:B:I157 10.85244.91NoNo087
104B:B:C149 B:B:T102 10.67818.45NoNo088
105B:B:C148 B:B:T102 10.50383.38NoNo068
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7V9L
Class B1
SubFamily Peptide
Type Glucagon
SubType GHRH (SV1)
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 2.6
Date 2022-04-06
D.O.I. 10.1073/pnas.2106606118
Net Summary
Imin 3.92
Number of Linked Nodes 836
Number of Links 995
Number of Hubs 164
Number of Links mediated by Hubs 604
Number of Communities 32
Number of Nodes involved in Communities 217
Number of Links involved in Communities 299
Path Summary
Number Of Nodes in MetaPath 106
Number Of Links MetaPath 105
Number of Shortest Paths 2099057
Length Of Smallest Path 3
Average Path Length 37.8871
Length of Longest Path 70
Minimum Path Strength 1.295
Average Path Strength 7.7504
Maximum Path Strength 25.1
Minimum Path Correlation 0.7
Average Path Correlation 0.983692
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.27273
Average % Of Corr. Nodes 37.176
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 41.0875
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7V9L_Chain_A
TLSAEDKAA VERSKMIEK QLQKDKQVY RATHRLLLL GADNSGKST 
IVKQMRIYH VVKTSGIFE TKFQVDKVN FHMFDVGAQ RDERRKWIQ 
CFNDVTAII FVVDSSDYR LQEALNDFK SIWNNRWLR TISVILFLN 
KQDLLAEKV LAGKSKIED YFPEFARYT TPEDATPEP GEDPRVTRA 
KYFIRDEFL RISTASGDG RHYCYPHFT CSVDTENAR RIFNDCRDI 
IQRMHLRQY ELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ9HB45
Sequence
>7V9L_Chain_R
FSTVKIIYT VGHSISIVA LFVAITILV ALRRLHCPR NYVHTQLFT 
TFILKAGAV FLKDAALFH SDDTDHFST VLCKVSVAA SHFATMTNF 
SWLLAEAVY LNCLLASTS PSSRRAFWW LVLAGWGLP VLFTGTWVS 
CKLAFEDIA CWDLDDTSP YWWIIKGPI VLSVGVNFG LFLNIIRIL 
VRKLETQSQ YWRLSKSTL FLIPLFGIH YIIFNFLPD NAGLGIRLP 
LELGLGSFQ GFIVAILYC FLNQEVRTE ISRKW


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP63212
Sequence
>7V9L_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFRE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP54311
Sequence
>7V9L_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7V9MB1PeptideGlucagonGHRH (SV1)Homo sapiensSomatoliberin-Gs/&β;1/&γ;23.292021-10-2010.1073/pnas.2106606118




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7V9L.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.