Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L5 2.8525402
2A:A:K34 4.625404
3A:A:H41 7.15106
4A:A:L46 5.824228
5A:A:N50 7.614599
6A:A:S51 4.155409
7A:A:K53 6.065409
8A:A:Y63 7.865409
9A:A:F219 8.386676108
10A:A:R232 8.5775438
11A:A:K233 6.11167639
12A:A:W234 8.08639
13A:A:C237 6.1438
14A:A:F238 11.105409
15A:A:D249 10.3125498
16A:A:S251 4.12499
17A:A:Y253 9.48754248
18A:A:R265 9.2175499
19A:A:F273 5.628336169
20A:A:W277 8.546676166
21A:A:W281 10.30176155
22A:A:I288 8.32254199
23A:A:L291 5.8408
24A:A:F312 5.182508
25A:A:F315 14.6125406
26A:A:P321 3.2275405
27A:A:E330 7.2125463
28A:A:V334 3.5275404
29A:A:K338 10.5425465
30A:A:Y339 7.4975463
31A:A:F340 10.39507
32A:A:R342 8.026564
33A:A:F345 9.3825408
34A:A:Y360 7.635408
35A:A:F363 11.134565
36A:A:R374 10.16754264
37A:A:I375 5.95254199
38A:A:F376 6.288577108
39A:A:H387 6.745408
40A:A:Y391 9.5625444
41B:B:L4 3.6425404
42B:B:I37 4.705672
43B:B:V40 6.1175473
44B:B:H54 9.656529
45B:B:W63 7.898527
46B:B:L70 6.7025425
47B:B:V71 6.03254118
48B:B:S72 5.426529
49B:B:Q75 10.01439
50B:B:D76 7.8325409
51B:B:L79 4.77254117
52B:B:I80 9.25428
53B:B:W82 10.9167629
54B:B:N88 7.0225407
55B:B:K89 6.382529
56B:B:H91 6.795405
57B:B:I93 7.16407
58B:B:L95 5.1085118
59B:B:W99 11.216509
60B:B:M101 6.715439
61B:B:Y105 5.901676116
62B:B:Y111 5.605404
63B:B:I123 5.105406
64B:B:Y124 6.1965116
65B:B:E130 8.0375403
66B:B:E138 7.4125406
67B:B:H142 8.4845129
68B:B:Y145 8.652538
69B:B:F151 6.14509
70B:B:L152 5.416293
71B:B:D163 7.4645129
72B:B:W169 11.6385128
73B:B:F180 9.128587
74B:B:H183 9.14689
75B:B:D186 6.986539
76B:B:F199 11.01489
77B:B:V200 7.596516
78B:B:C204 7.6375437
79B:B:D205 7.7489
80B:B:K209 10.236586
81B:B:L210 5.952505
82B:B:W211 9.38667688
83B:B:Q220 8.82417
84B:B:F222 11.4375418
85B:B:H225 9.71667619
86B:B:D228 8.452539
87B:B:I232 5.618518
88B:B:F234 5.846515
89B:B:F235 8.2645186
90B:B:P236 6.034187
91B:B:F241 9.11516
92B:B:T243 6.9825418
93B:B:D246 6.5375439
94B:B:D247 9.945419
95B:B:T249 7.1725416
96B:B:R251 11.14518
97B:B:F253 8.418516
98B:B:D254 7.675409
99B:B:R256 13.005409
100B:B:D258 10.8875417
101B:B:M262 7.7425404
102B:B:Y264 8.176505
103B:B:I269 3.94254134
104B:B:F278 5.623336187
105B:B:R283 8.09167679
106B:B:L285 4.6225406
107B:B:Y289 6.755717137
108B:B:D290 6.644156
109B:B:N295 9.0845136
110B:B:V296 3.915405
111B:B:D298 10.2025479
112B:B:L300 6.5625476
113B:B:V307 4.0845133
114B:B:H311 9.0945149
115B:B:R314 13.5285158
116B:B:W332 13.01176159
117B:B:L336 7.1075427
118B:B:K337 7.5585146
119B:B:I338 5.79425
120B:B:W339 12.88754149
121G:G:I9 3.5975402
122G:G:L19 3.675279
123G:G:R27 8.8175418
124G:G:Y40 10.454186
125G:G:D48 6.835409
126G:G:L51 4.152576
127G:G:N59 7.3075429
128G:G:P60 8.1825429
129G:G:F61 7.022528
130R:R:H137 6.9925307
131R:R:L151 5.465408
132R:R:L154 3.65547
133R:R:R156 7.5425447
134R:R:L157 5.5625448
135R:R:R161 9.10286749
136R:R:N162 6.775448
137R:R:H165 8.665449
138R:R:F169 4.8225408
139R:R:T171 6.0175408
140R:R:F172 10.036508
141R:R:L186 3.4065326
142R:R:F187 3.0175404
143R:R:H210 9.0425457
144R:R:F211 5.81408
145R:R:T215 6.7775408
146R:R:F217 9.53408
147R:R:W219 11.776209
148R:R:E223 10.2675449
149R:R:L231 5.1925408
150R:R:F256 6.6825455
151R:R:W260 9.285458
152R:R:W273 10.4333659
153R:R:Y281 10.945403
154R:R:W282 10.3875456
155R:R:I285 8.985457
156R:R:F300 8.575178
157R:R:K310 6.2145259
158R:R:F338 8.0825178
159R:R:Y342 11.014318
160R:R:F345 6.07606
161R:R:Q368 7.9854319
162R:R:Y376 10.6275408
163R:R:C377 4.585409
164R:R:N380 7.94449
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:M61 B:B:S72 14.0484.6NoYes269
2B:B:C317 B:B:M61 23.62179.73NoNo076
3B:B:C317 B:B:S316 23.93645.16NoNo079
4B:B:S316 B:B:W332 24.25094.94NoYes099
5A:A:W281 B:B:W332 15.2529.37YesYes1559
6A:A:N279 A:A:W281 60.02126.78NoYes085
7A:A:L282 A:A:N279 59.917413.73NoNo098
8A:A:I235 A:A:L282 30.6685.71NoNo099
9A:A:I235 A:A:W234 30.53857.05NoYes099
10A:A:Q227 A:A:W234 31.30498.76NoYes399
11A:A:Q227 B:B:N119 33.487411.88NoNo099
12B:B:G144 B:B:N119 33.03685.09NoNo089
13B:B:D163 B:B:G144 32.88645.03YesNo098
14B:B:D163 B:B:H142 32.27147.56YesYes1299
15B:B:H142 B:B:L146 18.03267.71YesNo1297
16B:B:G115 B:B:L146 18.45163.42NoNo097
17B:B:D118 B:B:G115 18.28393.35NoNo099
18B:B:D118 B:B:I120 17.94825.6NoNo096
19B:B:E138 B:B:I120 17.44376.83YesNo066
20B:B:K57 B:B:W332 10.154323.21NoYes099
21A:A:W281 B:B:D290 70.42147.82YesYes1556
22B:B:C271 B:B:D290 84.21634.67NoYes056
23B:B:C271 B:B:D291 84.30029.34NoNo058
24B:B:D291 B:B:Y289 84.21025.75NoYes087
25B:B:G288 B:B:Y289 99.93954.35NoYes077
26B:B:C294 B:B:G288 1003.92NoNo057
27B:B:C294 B:B:L308 49.95037.94NoNo057
28B:B:L308 B:B:W339 49.953723.92NoYes079
29B:B:K337 B:B:W339 49.90615.8YesYes1469
30B:B:K337 B:B:T50 99.99139.01YesNo063
31B:B:R52 B:B:T50 99.939810.35NoNo073
32B:B:R52 R:R:R155 99.887519.19NoNo078
33R:R:H158 R:R:R155 99.83594.51NoNo078
34R:R:H158 R:R:Y163 99.784110.89NoNo076
35R:R:F242 R:R:Y163 99.73217.22NoNo066
36R:R:F242 R:R:V246 99.62796.55NoNo065
37R:R:V246 R:R:W219 98.4927.36NoYes2059
38R:R:T171 R:R:W219 97.4646.06YesYes089
39R:R:L168 R:R:T171 48.51414.42NoYes098
40R:R:F172 R:R:L168 48.34957.31YesNo089
41R:R:F172 R:R:L144 77.82424.87YesNo089
42R:R:F169 R:R:L144 68.59596.09YesNo089
43R:R:F169 R:R:V372 48.07015.24YesNo088
44R:R:V372 R:R:Y376 47.85535.05NoYes088
45R:R:H165 R:R:Y376 40.78638.71YesYes098
46R:R:H165 R:R:R161 12.16014.51YesYes499
47A:A:Q390 R:R:R161 21.936214.02NoYes049
48A:A:H387 A:A:Q390 21.47236.18YesNo084
49A:A:H387 A:A:I383 15.43023.98YesNo088
50A:A:H41 A:A:I383 14.96455.3YesNo068
51B:B:R314 B:B:W332 13.475326.99YesYes1589
52B:B:D290 B:B:R314 13.630410.72YesYes1568
53B:B:C294 B:B:V315 50.11095.12NoNo057
54B:B:H311 B:B:V315 50.11444.15YesNo097
55B:B:H311 B:B:K337 50.132810.48YesYes1496
56R:R:N216 R:R:T171 48.51417.31NoYes088
57R:R:F172 R:R:N216 48.349516.92YesNo088
58R:R:C377 R:R:F169 19.95684.19YesYes098
59R:R:C377 R:R:L151 17.79836.35YesYes098
60R:R:L151 R:R:N162 14.46778.24YesYes088
61R:R:N162 R:R:R161 12.35448.44YesYes489
62A:A:Y391 R:R:H165 28.02335.44YesYes449
63A:A:Y391 R:R:L227 28.529112.89YesNo049
64R:R:L227 R:R:L231 28.06354.15NoYes098
65A:A:Q384 R:R:L231 12.75953.99NoYes068
66A:A:Q384 R:R:K310 12.52928.14NoYes069
67A:A:D381 R:R:K310 23.60136.91NoYes2589
68A:A:D381 A:A:Y360 23.144710.34NoYes088
69A:A:D378 A:A:Y360 21.77319.2NoYes078
70A:A:D378 A:A:I288 13.900516.79NoYes079
71R:R:I306 R:R:L231 13.21165.71NoYes078
72R:R:I306 R:R:K310 12.8644.36NoYes079
73A:A:L43 A:A:M221 11.1314.24NoNo078
74A:A:I276 A:A:L282 29.20184.28NoNo089
75A:A:I276 A:A:L46 29.07094.28NoYes088
76A:A:F363 A:A:L291 18.24167.31YesYes058
77A:A:F273 A:A:F345 18.32716.43YesYes098
78A:A:F246 A:A:F273 31.93175.36NoYes099
79A:A:F246 A:A:L46 32.06563.65NoYes098
80A:A:L289 A:A:L291 12.75066.92NoYes098
81B:B:W297 B:B:Y289 22.46414.82NoYes1387
82B:B:W297 B:B:Y264 22.620510.61NoYes085
83B:B:L252 B:B:Y264 16.71177.03NoYes075
84B:B:L252 B:B:L261 15.18355.54NoNo075
85B:B:L261 G:G:V30 13.78654.47NoNo058
86B:B:Q259 G:G:V30 13.62955.73NoNo068
87B:B:Q259 B:B:R22 13.31497.01NoNo066
88B:B:H142 B:B:W169 15.09666.35YesYes1298
89B:B:L139 B:B:W169 14.483626.19NoYes098
90B:B:I123 B:B:L139 14.14015.71YesNo069
91B:B:I123 B:B:I171 12.41527.36YesNo066
92B:B:I157 B:B:I171 12.24215.89NoNo076
93B:B:C149 B:B:I157 10.85244.91NoNo087
94B:B:C149 B:B:T102 10.67818.45NoNo088
95B:B:C148 B:B:T102 10.50383.38NoNo068
96R:R:I173 R:R:L144 10.69285.71NoNo079
97R:R:F145 R:R:I173 10.452410.05NoNo037
98R:R:F145 R:R:I141 10.21182.51NoNo037
99R:R:F172 R:R:Q368 20.237410.54YesYes089
100R:R:Q368 R:R:Y342 19.30844.51YesYes3198
101R:R:E361 R:R:Y342 15.28425.61NoYes078
102R:R:E361 R:R:R357 15.049220.93NoNo076
103R:R:D350 R:R:R357 12.69275.96NoNo056
104R:R:D350 R:R:K286 12.456412.44NoNo056
105R:R:K286 R:R:W282 11.98348.12NoYes066
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7V9L
Class B1
SubFamily Peptide
Type Glucagon
SubType GHRH (SV1)
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 2.6
Date 2022-04-06
D.O.I. doi.org/10.1073/pnas.2106606118
Net Summary
Imin 3.92
Number of Linked Nodes 836
Number of Links 995
Number of Hubs 164
Number of Links mediated by Hubs 604
Number of Communities 32
Number of Nodes involved in Communities 217
Number of Links involved in Communities 299
Path Summary
Number Of Nodes in MetaPath 106
Number Of Links MetaPath 105
Number of Shortest Paths 2099057
Length Of Smallest Path 3
Average Path Length 37.8846
Length of Longest Path 70
Minimum Path Strength 1.295
Average Path Strength 7.75038
Maximum Path Strength 25.1
Minimum Path Correlation 0.7
Average Path Correlation 0.983656
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.27273
Average % Of Corr. Nodes 37.248
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 41.0954
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• cytoskeletal protein binding   • spectrin binding   • protein-containing complex binding   • protein binding   • binding   • enzyme binding   • GTPase binding   • phosphoric ester hydrolase activity   • alkylglycerophosphoethanolamine phosphodiesterase activity   • hydrolase activity, acting on ester bonds   • phosphoric diester hydrolase activity   • hydrolase activity   • catalytic activity   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity, acting on acid anhydrides   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • positive regulation of cytosolic calcium ion concentration   • biological regulation   • regulation of biological quality   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye
Gene OntologyBiological Process• positive regulation of cytosolic calcium ion concentration   • biological regulation   • regulation of biological quality   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • response to decreased oxygen levels   • cellular response to stimulus   • response to stimulus   • cellular response to oxygen levels   • cellular response to hypoxia   • cellular response to decreased oxygen levels   • cellular response to chemical stimulus   • cellular response to stress   • response to hypoxia   • response to stress   • response to chemical   • response to oxygen levels   • response to abiotic stimulus   • cellular process   • cell population proliferation   • regulation of biological process   • regulation of cellular process   • signaling   • phospholipase C-activating G protein-coupled receptor signaling pathway   • cell communication   • G protein-coupled receptor signaling pathway   • signal transduction   • muscle cell apoptotic process   • striated muscle cell apoptotic process   • apoptotic process   • cell death   • programmed cell death   • cardiac muscle cell apoptotic process   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cellular anatomical structure   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cellular anatomical structure   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • photoreceptor inner segment   • somatodendritic compartment   • cell projection   • dendrite   • dendritic tree   • neuron projection   • plasma membrane bounded cell projection   • intracellular anatomical structure   • cytoplasm   • membrane-bounded organelle   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • photoreceptor outer segment   • photoreceptor cell cilium   • organelle   • ciliary membrane   • photoreceptor outer segment membrane   • bounding membrane of organelle   • plasma membrane region   • organelle membrane   • cell projection membrane   • synapse   • cell junction   • cell body   • protein binding   • binding   • G-protein beta-subunit binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • cellular process   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • molecular transducer activity   • G protein-coupled receptor activity   • growth hormone-releasing hormone receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • cell surface receptor signaling pathway   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • molecular function regulator activity   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • cation binding   • metal ion binding   • D2 dopamine receptor binding   • adenylate cyclase inhibitor activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • enzyme inhibitor activity   • magnesium ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to glucagon   • cellular response to glucagon stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • positive regulation of cellular process   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • localization   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of signaling   • regulation of transport   • secretion   • regulation of hormone levels   • regulation of peptide transport   • regulation of establishment of protein localization   • establishment of protein localization to extracellular region   • export from cell   • cell-cell signaling   • regulation of protein transport   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • cellular localization   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • cell division   • leukocyte migration   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • negative regulation of protein transport   • negative regulation of transport   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • negative regulation of peptide hormone secretion   • negative regulation of establishment of protein localization   • negative regulation of protein secretion   • negative regulation of signaling   • negative regulation of cell communication   • negative regulation of peptide secretion   • negative regulation of cellular process   • negative regulation of protein localization   • negative regulation of insulin secretion   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • positive regulation of protein localization   • protein localization to cell cortex   • cellular response to forskolin   • response to forskolin   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • trans-Golgi network   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • lysosomal membrane   • lysosome   • ciliary basal body
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7V9L_Chain_A
TLSAEDKAA VERSKMIEK QLQKDKQVY RATHRLLLL GADNSGKST 
IVKQMRIYH VVKTSGIFE TKFQVDKVN FHMFDVGAQ RDERRKWIQ 
CFNDVTAII FVVDSSDYR LQEALNDFK SIWNNRWLR TISVILFLN 
KQDLLAEKV LAGKSKIED YFPEFARYT TPEDATPEP GEDPRVTRA 
KYFIRDEFL RISTASGDG RHYCYPHFT CSVDTENAR RIFNDCRDI 
IQRMHLRQY ELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP54311
Sequence
>7V9L_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP63212
Sequence
>7V9L_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFRE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ02643
Sequence
>7V9L_Chain_R
FSTVKIIYT VGHSISIVA LFVAITILV ALRRLHCPR NYVHTQLFT 
TFILKAGAV FLKDAALFH SDDTDHFST VLCKVSVAA SHFATMTNF 
SWLLAEAVY LNCLLASTS PSSRRAFWW LVLAGWGLP VLFTGTWVS 
CKLAFEDIA CWDLDDTSP YWWIIKGPI VLSVGVNFG LFLNIIRIL 
VRKLETQSQ YWRLSKSTL FLIPLFGIH YIIFNFLPD NAGLGIRLP 
LELGLGSFQ GFIVAILYC FLNQEVRTE ISRKW


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7V9MB1PeptideGlucagonGHRH (SV1)Homo sapiensSomatoliberin-Gs/β1/γ23.292021-10-20doi.org/10.1073/pnas.2106606118
7V9M (No Gprot) B1PeptideGlucagonGHRH (SV1)Homo sapiensSomatoliberin-3.292021-10-20doi.org/10.1073/pnas.2106606118
7V9L (No Gprot) B1PeptideGlucagonGHRH (SV1)Homo sapiens--2.62022-04-06doi.org/10.1073/pnas.2106606118




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