Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:Y1 7.81610
2L:L:D3 8.4400
3L:L:F6 5.335430
4L:L:Y10 8.984530
5R:R:F126 7.42534
6R:R:Y133 10.09447
7R:R:H137 4.746547
8R:R:L154 4.825407
9R:R:N162 5.9925408
10R:R:H165 8.2429
11R:R:T171 6.0175408
12R:R:F172 7.805408
13R:R:K203 8.3375417
14R:R:H210 6.178517
15R:R:F211 6.1325408
16R:R:T215 6.7775408
17R:R:N216 7.62408
18R:R:W219 8.77857769
19R:R:Y226 5.855408
20R:R:W260 8.214518
21R:R:K264 9.7325417
22R:R:W273 10.758519
23R:R:P280 3.98402
24R:R:Y281 8.1675403
25R:R:W282 4.67516
26R:R:F297 6.915405
27R:R:F300 8.785488
28R:R:I303 5.92428
29R:R:L337 8.96429
30R:R:F338 5.518528
31R:R:I343 6.3025405
32R:R:F345 8.0725406
33R:R:S366 4.684509
34R:R:C377 5.115409
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:D3 L:L:Y1 54.34575.75YesYes000
2L:L:Y1 R:R:H210 40.37889.8YesYes107
3L:L:Y1 R:R:I289 91.95744.84YesNo007
4R:R:E361 R:R:Y342 10.530711.22NoNo078
5L:L:D3 R:R:Y133 48.98628.05YesYes007
6R:R:L362 R:R:Y133 35.07827.03NoYes077
7L:L:F6 R:R:L362 29.87984.87YesNo007
8L:L:F6 L:L:Y10 19.31288.25YesYes300
9L:L:Y10 R:R:H188 14.4849.8YesNo004
10R:R:H188 R:R:L186 13.55643.86NoNo046
11R:R:H137 R:R:Y133 13.74237.62YesYes477
12R:R:I289 R:R:M214 89.60764.37NoNo075
13R:R:M214 R:R:P253 93.43165.03NoNo059
14R:R:P253 R:R:T215 63.91936.99NoYes098
15R:R:T171 R:R:T215 33.77186.28YesYes088
16R:R:T171 R:R:W219 44.64286.06YesYes089
17R:R:V164 R:R:W219 1003.68NoYes089
18R:R:E223 R:R:V164 92.03459.98NoNo098
19R:R:E223 R:R:H165 46.795213.54NoYes299
20R:R:H165 R:R:R161 45.26424.51YesNo099
21R:R:N162 R:R:R161 37.42129.64YesNo089
22R:R:L151 R:R:N162 28.89095.49NoYes088
23R:R:C377 R:R:L151 19.5356.35YesNo098
24R:R:C377 R:R:F378 11.17945.59YesNo098
25R:R:F378 R:R:I374 10.08173.77NoNo085
26R:R:T215 R:R:W250 32.27726.06YesNo089
27R:R:W219 R:R:W250 31.696521.56YesNo699
28R:R:P253 R:R:S218 30.28587.13NoNo096
29R:R:G249 R:R:S218 30.28353.71NoNo096
30R:R:G249 R:R:W219 30.35385.63NoYes099
31R:R:F172 R:R:Q368 10.43097.03YesNo089
32R:R:V246 R:R:W219 10.01814.9NoYes059
33R:R:V164 R:R:Y226 12.32933.79NoYes088
34R:R:E223 R:R:L337 44.538410.6NoYes299
35R:R:H210 R:R:W260 37.87486.35YesYes178
36R:R:W260 R:R:W273 18.768411.25YesYes189
37R:R:K203 R:R:W273 16.128412.76YesYes179
38R:R:C272 R:R:K203 13.93296.47NoYes097
39R:R:C202 R:R:C272 12.79663.64NoNo099
40R:R:C202 R:R:T199 11.65571.69NoNo093
41R:R:F338 R:R:L337 42.9447.31YesYes289
42R:R:K264 R:R:W260 15.4239.28YesYes178
43R:R:E268 R:R:K264 12.72858.1NoYes057
44R:R:F338 R:R:L334 25.56594.87YesNo089
45R:R:F300 R:R:L334 24.52716.09YesNo089
46R:R:F300 R:R:I340 16.529815.07YesNo086
47R:R:F297 R:R:I340 11.22483.77YesNo056
48R:R:L375 R:R:Y376 10.11343.52NoNo078
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:Y1 R:R:H210 9.8 1 Yes Yes 0 7 0 1
L:L:Y1 R:R:T213 14.98 1 Yes No 0 5 0 1
L:L:Y1 R:R:W282 4.82 1 Yes Yes 0 6 0 1
L:L:Y1 R:R:I289 4.84 1 Yes No 0 7 0 1
L:L:A2 R:R:E361 4.53 0 No No 0 7 0 1
L:L:D3 R:R:Y133 8.05 0 Yes Yes 0 7 0 1
L:L:D3 R:R:K182 12.44 0 Yes No 0 6 0 1
L:L:D3 R:R:S209 7.36 0 Yes No 0 6 0 1
L:L:A4 R:R:W282 3.89 1 No Yes 0 6 0 1
L:L:I5 R:R:L354 8.56 5 No No 0 3 0 1
L:L:I5 R:R:L358 7.14 5 No No 0 6 0 1
L:L:F6 R:R:F126 4.29 3 Yes Yes 0 4 0 1
L:L:F6 R:R:V129 3.93 3 Yes No 0 6 0 1
L:L:F6 R:R:L362 4.87 3 Yes No 0 7 0 1
L:L:T7 R:R:K182 4.5 0 No No 0 6 0 1
L:L:N8 R:R:L275 5.49 0 No No 0 4 0 1
L:L:S9 R:R:F126 6.61 0 No Yes 0 4 0 1
L:L:Y10 R:R:F126 10.32 3 Yes Yes 0 4 0 1
L:L:Y10 R:R:K130 7.17 3 Yes No 0 5 0 1
L:L:Y10 R:R:H188 9.8 3 Yes No 0 4 0 1
L:L:R11 R:R:L186 7.29 0 No No 0 6 0 1
L:L:R11 R:R:D274 15.48 0 No No 0 6 0 1
L:L:V13 R:R:E122 12.84 3 No No 0 4 0 1
L:L:V13 R:R:E123 4.28 3 No No 0 2 0 1
L:L:V13 R:R:F126 6.55 3 No Yes 0 4 0 1
L:L:L14 R:R:E123 3.98 0 No No 0 2 0 1
L:L:S18 R:R:D193 10.31 0 No No 0 2 0 1
R:R:E122 R:R:F126 9.33 3 No Yes 4 4 1 1
R:R:D183 R:R:K130 4.15 0 No No 7 5 2 1
R:R:H137 R:R:Y133 7.62 4 Yes Yes 7 7 2 1
R:R:V179 R:R:Y133 17.66 4 No Yes 7 7 2 1
R:R:L362 R:R:Y133 7.03 0 No Yes 7 7 1 1
R:R:H137 R:R:V179 4.15 4 Yes No 7 7 2 2
R:R:H188 R:R:L186 3.86 0 No No 4 6 1 1
R:R:H194 R:R:L186 7.71 0 No No 4 6 2 1
R:R:C195 R:R:D193 9.34 0 No No 4 2 1 1
R:R:H210 R:R:V206 4.15 1 Yes No 7 5 1 2
R:R:H210 R:R:W260 6.35 1 Yes Yes 7 8 1 2
R:R:H210 R:R:W282 5.29 1 Yes Yes 7 6 1 1
R:R:H210 R:R:I285 5.3 1 Yes No 7 7 1 2
R:R:I289 R:R:M214 4.37 0 No No 7 5 1 2
R:R:F217 R:R:I289 13.82 0 No No 8 7 2 1
R:R:F217 R:R:Y342 16.5 0 No No 8 8 2 2
R:R:I285 R:R:W260 11.74 1 No Yes 7 8 2 2
R:R:I285 R:R:W282 5.87 1 No Yes 7 6 2 1
R:R:E361 R:R:Y342 11.22 0 No No 7 8 1 2
R:R:L354 R:R:L358 5.54 5 No No 3 6 1 1
R:R:E361 R:R:R357 18.61 0 No No 7 6 1 2
R:R:L358 R:R:L362 4.15 5 No No 6 7 1 1
R:R:K286 R:R:W282 3.48 0 No Yes 6 6 2 1
R:R:D274 R:R:L275 2.71 0 No No 6 4 1 1
R:R:V129 R:R:Y125 2.52 0 No No 6 4 1 2
L:L:G15 R:R:C195 1.96 0 No No 0 4 0 1
R:R:A178 R:R:S209 1.71 0 No No 6 6 2 1
R:R:L354 R:R:N351 1.37 5 No No 3 4 1 2
L:L:N8 R:R:D277 1.35 0 No No 0 3 0 1
R:R:D193 R:R:H194 1.26 0 No No 2 4 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 7V9M_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.68
Number of Linked Nodes 264
Number of Links 286
Number of Hubs 34
Number of Links mediated by Hubs 125
Number of Communities 8
Number of Nodes involved in Communities 38
Number of Links involved in Communities 47
Path Summary
Number Of Nodes in MetaPath 49
Number Of Links MetaPath 48
Number of Shortest Paths 64338
Length Of Smallest Path 3
Average Path Length 16.2589
Length of Longest Path 33
Minimum Path Strength 1.195
Average Path Strength 6.88388
Maximum Path Strength 17.32
Minimum Path Correlation 0.7
Average Path Correlation 0.920144
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.57143
Average % Of Corr. Nodes 42.4328
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 40.7631
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • cellular process   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • cell periphery   • cellular anatomical structure   • plasma membrane   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cell periphery   • cellular anatomical structure   • plasma membrane   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • molecular transducer activity   • G protein-coupled receptor activity   • growth hormone-releasing hormone receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • cell surface receptor signaling pathway   • response to stimulus   • signaling   • biological regulation   • cellular process   • signal transduction   • cell communication   • hormone activity   • growth hormone-releasing hormone activity   • protein binding   • binding   • molecular function activator activity   • signaling receptor binding   • molecular function regulator activity   • signaling receptor regulator activity   • receptor ligand activity   • signaling receptor activator activity   • growth hormone-releasing hormone receptor binding   • G protein-coupled receptor binding   • neuropeptide receptor binding   • neuropeptide activity   • neuropeptide hormone activity   • peptide hormone receptor binding   • hormone receptor binding   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cell population proliferation   • positive regulation of cell population proliferation   • regulation of cell population proliferation   • positive regulation of biological process   • positive regulation of cellular process   • developmental process   • multicellular organismal process   • head development   • forebrain development   • endocrine system development   • pituitary gland development   • gland development   • animal organ development   • brain development   • diencephalon development   • nervous system development   • multicellular organism development   • central nervous system development   • anatomical structure development   • adenohypophysis development   • system development   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of signal transduction   • cell surface receptor protein tyrosine kinase signaling pathway   • positive regulation of response to stimulus   • positive regulation of insulin-like growth factor receptor signaling pathway   • regulation of insulin-like growth factor receptor signaling pathway   • enzyme-linked receptor protein signaling pathway   • regulation of signaling   • insulin-like growth factor receptor signaling pathway   • regulation of response to stimulus   • regulation of cell communication   • positive regulation of signaling   • regulation of localization   • localization   • regulation of protein localization   • macromolecule localization   • intracellular protein localization   • regulation of multicellular organism growth   • regulation of growth   • regulation of developmental growth   • regulation of developmental process   • developmental growth   • growth   • positive regulation of multicellular organism growth   • positive regulation of developmental process   • multicellular organism growth   • positive regulation of growth   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • positive regulation of developmental growth   • cell-cell signaling   • nitrogen compound transport   • transport   • hormone secretion   • peptide secretion   • secretion by cell   • amide transport   • signal release   • regulation of biological quality   • growth hormone secretion   • secretion   • regulation of hormone levels   • export from cell   • establishment of localization   • peptide transport   • peptide hormone secretion   • hormone transport   • regulation of circadian sleep/wake cycle   • regulation of circadian rhythm   • regulation of behavior   • sleep   • rhythmic process   • circadian sleep/wake cycle, sleep   • circadian sleep/wake cycle   • rhythmic behavior   • circadian rhythm   • regulation of circadian sleep/wake cycle, REM sleep   • behavior   • circadian behavior   • circadian sleep/wake cycle, REM sleep   • positive regulation of behavior   • positive regulation of circadian rhythm   • positive regulation of circadian sleep/wake cycle, REM sleep   • positive regulation of circadian sleep/wake cycle, sleep   • regulation of circadian sleep/wake cycle, sleep   • circadian sleep/wake cycle process   • regulation of hormone secretion   • regulation of peptide secretion   • positive regulation of secretion by cell   • regulation of secretion by cell   • positive regulation of hormone secretion   • positive regulation of secretion   • regulation of peptide hormone secretion   • positive regulation of peptide secretion   • regulation of transport   • regulation of growth hormone secretion   • regulation of peptide transport   • positive regulation of peptide hormone secretion   • regulation of secretion   • positive regulation of growth hormone secretion   • positive regulation of transport   • response to nutrient levels   • response to food   • response to chemical   • somatodendritic compartment   • cell body   • perikaryon   • neuronal cell body   • extracellular region   • axon   • synapse   • neuron projection   • axon terminus   • plasma membrane bounded cell projection   • presynapse   • cell projection   • distal axon   • terminal bouton   • cell junction   • neuron projection terminus   • extracellular space   • cytoskeletal protein binding   • spectrin binding   • protein-containing complex binding   • enzyme binding   • GTPase binding   • phosphoric ester hydrolase activity   • alkylglycerophosphoethanolamine phosphodiesterase activity   • hydrolase activity, acting on ester bonds   • phosphoric diester hydrolase activity   • hydrolase activity   • catalytic activity   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity, acting on acid anhydrides   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • positive regulation of cytosolic calcium ion concentration   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • sensory organ development   • eye development   • retina development in camera-type eye   • visual system development   • camera-type eye development   • sensory system development   • response to decreased oxygen levels   • cellular response to oxygen levels   • cellular response to hypoxia   • cellular response to decreased oxygen levels   • cellular response to chemical stimulus   • cellular response to stress   • response to hypoxia   • response to stress   • response to oxygen levels   • response to abiotic stimulus   • phospholipase C-activating G protein-coupled receptor signaling pathway   • muscle cell apoptotic process   • striated muscle cell apoptotic process   • apoptotic process   • cell death   • programmed cell death   • cardiac muscle cell apoptotic process   • photoreceptor inner segment   • dendrite   • dendritic tree   • intracellular anatomical structure   • cytoplasm   • membrane-bounded organelle   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • photoreceptor outer segment   • photoreceptor cell cilium   • organelle   • ciliary membrane   • photoreceptor outer segment membrane   • bounding membrane of organelle   • plasma membrane region   • organelle membrane   • cell projection membrane   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • dopamine receptor binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • cation binding   • metal ion binding   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • sensory perception of smell   • cellular response to nitrogen compound   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • response to hormone   • cellular response to hormone stimulus   • skeletal system development   • bone development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • coagulation   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • homeostatic process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • metabolic process   • regulation of metabolic process   • establishment of protein localization   • protein localization to extracellular region   • regulation of establishment of protein localization   • establishment of protein localization to extracellular region   • regulation of protein transport   • protein secretion   • regulation of protein secretion   • protein transport   • regulation of insulin secretion   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • cellular localization   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • vesicle   • extracellular membrane-bounded organelle   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • trans-Golgi network
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ02643
Sequence
>7V9M_nogp_Chain_R
LAEEESYFS TVKIIYTVG HSISIVALF VAITILVAL RRLHCPRNY 
VHTQLFTTF ILKAGAVFL KDAALFHSD DTDHCSFST VLCKVSVAA 
SHFATMTNF SWLLAEAVY LNCLLASTS PSSRRAFWW LVLAGWGLP 
VLFTGTWVS CKLAFEDIA CWDLDDTSP YWWIIKGPI VLSVGVNFG 
LFLNIIRIL VRKLESQYW RLSKSTLFL IPLFGIHYI IFNFLPDNA 
GLGIRLPLE LGLGSFQGF IVAILYCFL NQEVRTEIS RKWH


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7V9MB1PeptideGlucagonGHRH (SV1)Homo sapiensSomatoliberin-Gs/β1/γ23.292021-10-20doi.org/10.1073/pnas.2106606118
7V9M (No Gprot) B1PeptideGlucagonGHRH (SV1)Homo sapiensSomatoliberin-3.292021-10-20doi.org/10.1073/pnas.2106606118
7V9LB1PeptideGlucagonGHRH (SV1)Homo sapiens--chim(NtGi1-Gs)/β1/γ22.62022-04-06doi.org/10.1073/pnas.2106606118
7V9L (No Gprot) B1PeptideGlucagonGHRH (SV1)Homo sapiens--2.62022-04-06doi.org/10.1073/pnas.2106606118




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Download 7V9M_nogp.zip



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