psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H137	R:R:Y133	9.8	Yes	No	4	7	7
2	R:R:V179	R:R:Y133	8.83	No	No	4	7	7
3	R:R:L362	R:R:Y133	4.69	No	No	0	7	7
4	R:R:F180	R:R:T134	5.19	No	No	0	7	6
5	R:R:F367	R:R:G136	9.03	No	No	0	7	8
6	R:R:A176	R:R:H137	5.85	No	Yes	0	8	7
7	R:R:H137	R:R:V179	4.15	Yes	No	4	7	7
8	R:R:F180	R:R:H137	6.79	No	Yes	0	7	7
9	R:R:H137	R:R:S366	8.37	Yes	No	0	7	9
10	R:R:F370	R:R:I139	7.54	No	No	0	4	5
11	R:R:F180	R:R:I141	3.77	No	No	0	7	7
12	R:R:F169	R:R:L144	6.09	Yes	No	0	8	9
13	R:R:F172	R:R:L144	4.87	Yes	No	0	8	9
14	R:R:I173	R:R:L144	5.71	No	No	0	7	9
15	R:R:F145	R:R:I173	10.05	No	No	0	3	7
16	R:R:F169	R:R:I148	3.77	Yes	No	0	8	5
17	R:R:L151	R:R:N162	8.24	Yes	Yes	0	8	8
18	R:R:L151	R:R:T166	4.42	Yes	No	0	8	6
19	R:R:C377	R:R:L151	6.35	Yes	Yes	0	9	8
20	R:R:L154	R:R:L157	5.54	Yes	Yes	1	7	8
21	R:R:E386	R:R:L154	5.3	No	Yes	1	8	7
22	R:R:H158	R:R:R155	4.51	No	No	0	7	8
23	R:R:E386	R:R:R156	16.28	No	No	0	8	7
24	R:R:R156	R:R:R389	4.26	No	No	0	7	7
25	R:R:L157	R:R:N162	4.12	Yes	Yes	1	8	8
26	R:R:L157	R:R:V383	5.96	Yes	No	0	8	9
27	R:R:E386	R:R:L157	6.63	No	Yes	1	8	8
28	R:R:H158	R:R:Y163	10.89	No	No	0	7	6
29	R:R:C159	R:R:R161	8.36	No	Yes	1	8	9
30	R:R:C159	R:R:N162	6.3	No	Yes	1	8	8
31	R:R:P160	R:R:Y226	6.95	No	Yes	0	7	8
32	R:R:N162	R:R:R161	8.44	Yes	Yes	1	8	9
33	R:R:H165	R:R:R161	4.51	Yes	Yes	1	9	9
34	R:R:N380	R:R:R161	4.82	No	Yes	1	9	9
35	R:R:E382	R:R:R161	8.14	No	Yes	1	9	9
36	R:R:F242	R:R:Y163	7.22	No	No	0	6	6
37	R:R:E223	R:R:V164	9.98	No	No	0	9	8
38	R:R:V164	R:R:Y226	3.79	No	Yes	0	8	8
39	R:R:E223	R:R:H165	16	No	Yes	1	9	9
40	R:R:H165	R:R:L337	3.86	Yes	Yes	1	9	9
41	R:R:H165	R:R:Y376	8.71	Yes	Yes	1	9	8
42	R:R:Q167	R:R:W219	21.9	No	Yes	3	9	9
43	R:R:Q167	R:R:V246	8.6	No	No	3	9	5
44	R:R:Q167	R:R:W250	7.67	No	No	3	9	9
45	R:R:L168	R:R:T171	4.42	No	Yes	0	9	8
46	R:R:F172	R:R:L168	7.31	Yes	No	0	8	9
47	R:R:L168	R:R:L220	5.54	No	No	0	9	9
48	R:R:F169	R:R:V372	5.24	Yes	No	0	8	8
49	R:R:C377	R:R:F169	4.19	Yes	Yes	0	9	8
50	R:R:T171	R:R:T215	6.28	Yes	Yes	0	8	8
51	R:R:N216	R:R:T171	7.31	No	Yes	0	8	8
52	R:R:T171	R:R:W219	6.06	Yes	Yes	0	8	9
53	R:R:F172	R:R:N216	16.92	Yes	No	0	8	8
54	R:R:F172	R:R:Q368	10.54	Yes	Yes	0	8	9
55	R:R:F172	R:R:G369	10.54	Yes	No	0	8	9
56	R:R:K175	R:R:N216	5.6	No	No	0	8	8
57	R:R:K182	R:R:S205	6.12	No	No	0	6	5
58	R:R:K182	R:R:S209	12.24	No	No	0	6	6
59	R:R:D183	R:R:F187	4.78	No	Yes	0	7	4
60	R:R:D274	R:R:L186	5.43	No	Yes	0	6	6
61	R:R:D193	R:R:H188	3.78	No	No	0	2	4
62	R:R:S189	R:R:S198	4.89	No	No	0	3	6
63	R:R:D191	R:R:T192	7.23	No	No	0	3	4
64	R:R:H194	R:R:S198	8.37	No	No	0	4	6
65	R:R:C202	R:R:C272	7.28	No	No	6	9	9
66	R:R:D269	R:R:K203	9.68	No	No	2	5	7
67	R:R:K203	R:R:W273	35.97	No	Yes	2	7	9
68	R:R:H210	R:R:V206	4.15	Yes	No	0	7	5
69	R:R:H210	R:R:W260	13.75	Yes	Yes	2	7	8
70	R:R:H210	R:R:W282	11.64	Yes	Yes	2	7	6
71	R:R:H210	R:R:I285	6.63	Yes	Yes	2	7	7
72	R:R:F211	R:R:T215	7.78	Yes	Yes	0	8	8
73	R:R:F211	R:R:V254	5.24	Yes	No	0	8	3
74	R:R:F211	R:R:T257	7.78	Yes	No	0	8	6
75	R:R:F256	R:R:M214	4.98	Yes	No	2	5	5
76	R:R:I285	R:R:M214	5.83	Yes	No	2	7	5
77	R:R:M214	R:R:P288	5.03	No	No	2	5	8
78	R:R:T215	R:R:W250	6.06	Yes	No	0	8	9
79	R:R:P253	R:R:T215	6.99	No	Yes	0	9	8
80	R:R:F217	R:R:I289	15.07	Yes	No	0	8	7
81	R:R:F217	R:R:S292	3.96	Yes	No	0	8	7
82	R:R:F217	R:R:Y342	16.5	Yes	Yes	0	8	8
83	R:R:P253	R:R:S218	7.13	No	No	0	9	6
84	R:R:A222	R:R:W219	3.89	No	Yes	0	8	9
85	R:R:V246	R:R:W219	7.36	No	Yes	3	5	9
86	R:R:G249	R:R:W219	7.04	No	Yes	0	9	9
87	R:R:W219	R:R:W250	24.37	Yes	No	3	9	9
88	R:R:E223	R:R:L337	10.6	No	Yes	1	9	9
89	R:R:A224	R:R:L299	4.73	No	No	0	8	8
90	R:R:A224	R:R:F338	8.32	No	Yes	0	8	8
91	R:R:L245	R:R:V225	4.47	No	No	0	7	6
92	R:R:L230	R:R:Y226	15.24	No	Yes	0	7	8
93	R:R:L227	R:R:L231	4.15	No	No	0	9	8
94	R:R:I303	R:R:L227	8.56	No	No	0	8	9
95	R:R:L299	R:R:N228	13.73	No	No	0	8	8
96	R:R:N228	R:R:N302	5.45	No	No	0	8	7
97	R:R:I303	R:R:N228	7.08	No	No	0	8	8
98	R:R:I306	R:R:L231	5.71	No	No	0	7	8
99	R:R:S235	R:R:S237	6.52	No	No	0	7	6
100	R:R:F242	R:R:W243	13.03	No	No	0	6	2
101	R:R:F242	R:R:V246	6.55	No	No	0	6	5
102	R:R:F256	R:R:P288	14.45	Yes	No	2	5	8
103	R:R:I284	R:R:T259	4.56	No	No	0	7	5
104	R:R:K264	R:R:W260	6.96	No	Yes	2	7	8
105	R:R:W260	R:R:W273	4.69	Yes	Yes	2	8	9
106	R:R:I285	R:R:W260	11.74	Yes	Yes	2	7	8
107	R:R:C263	R:R:Y281	8.06	No	Yes	0	4	3
108	R:R:K264	R:R:W273	8.12	No	Yes	2	7	9
109	R:R:K264	R:R:T278	7.51	No	No	0	7	5
110	R:R:L265	R:R:W273	4.56	No	Yes	0	3	9
111	R:R:A266	R:R:F267	4.16	No	No	0	3	3
112	R:R:F267	R:R:Y281	19.6	No	Yes	0	3	3
113	R:R:E268	R:R:T278	15.52	No	No	0	5	5
114	R:R:D269	R:R:W273	5.58	No	Yes	2	5	9
115	R:R:I270	R:R:L275	8.56	No	No	0	4	4
116	R:R:D276	R:R:W282	10.05	No	Yes	0	6	6
117	R:R:T278	R:R:Y281	4.99	No	Yes	0	5	3
118	R:R:P280	R:R:Y281	11.13	No	Yes	0	2	3
119	R:R:I285	R:R:W282	11.74	Yes	Yes	2	7	6
120	R:R:K286	R:R:W282	8.12	No	Yes	0	6	6
121	R:R:K286	R:R:W283	19.73	No	No	0	6	8
122	R:R:D350	R:R:K286	12.44	No	No	0	5	6
123	R:R:G287	R:R:P288	4.06	No	No	0	4	8
124	R:R:N346	R:R:V290	13.3	No	No	0	5	4
125	R:R:N346	R:R:V293	14.78	No	No	0	5	7
126	R:R:F338	R:R:N296	8.46	Yes	No	0	8	9
127	R:R:I340	R:R:N296	4.25	No	No	0	6	9
128	R:R:F297	R:R:L301	8.53	No	No	0	5	5
129	R:R:F297	R:R:I343	11.3	No	No	0	5	5
130	R:R:F300	R:R:I304	10.05	Yes	No	0	8	6
131	R:R:F300	R:R:L334	6.09	Yes	No	1	8	9
132	R:R:F300	R:R:I335	6.28	Yes	No	1	8	8
133	R:R:F300	R:R:F338	5.36	Yes	Yes	1	8	8
134	R:R:F300	R:R:I340	15.07	Yes	No	1	8	6
135	R:R:N302	R:R:R305	8.44	No	No	0	7	7
136	R:R:I304	R:R:T331	4.56	No	No	0	6	8
137	R:R:I306	R:R:R305	5.01	No	No	0	7	7
138	R:R:I306	R:R:K310	4.36	No	No	0	7	9
139	R:R:L307	R:R:L327	4.15	No	No	0	8	8
140	R:R:E312	R:R:V308	5.7	No	No	0	6	5
141	R:R:L327	R:R:V308	4.47	No	No	0	8	5
142	R:R:L311	R:R:Q323	7.99	No	No	0	7	6
143	R:R:L311	R:R:L327	4.15	No	No	0	7	8
144	R:R:K329	R:R:W325	9.28	No	No	0	8	6
145	R:R:K329	R:R:R326	14.85	No	No	0	8	7
146	R:R:R326	R:R:S330	6.59	No	No	0	7	8
147	R:R:F333	R:R:K329	6.2	No	No	0	8	8
148	R:R:F333	R:R:L375	7.31	No	No	0	8	7
149	R:R:F333	R:R:Y376	4.13	No	Yes	0	8	8
150	R:R:F338	R:R:L334	9.74	Yes	No	1	8	9
151	R:R:I335	R:R:I340	4.42	No	No	1	8	6
152	R:R:F338	R:R:L337	8.53	Yes	Yes	1	8	9
153	R:R:L337	R:R:Y376	24.62	Yes	Yes	1	9	8
154	R:R:H341	R:R:Y342	17.42	No	Yes	5	8	8
155	R:R:H341	R:R:Q368	13.6	No	Yes	5	8	9
156	R:R:E361	R:R:Y342	5.61	No	Yes	0	7	8
157	R:R:Q368	R:R:Y342	4.51	Yes	Yes	5	9	8
158	R:R:F347	R:R:I343	3.77	No	No	0	5	5
159	R:R:F345	R:R:I344	11.3	Yes	No	0	6	6
160	R:R:F345	R:R:I356	3.77	Yes	No	0	6	5
161	R:R:F345	R:R:R357	14.97	Yes	No	0	6	6
162	R:R:F347	R:R:N346	10.87	No	No	0	5	5
163	R:R:A352	R:R:L348	4.73	No	No	0	3	5
164	R:R:D350	R:R:R357	5.96	No	No	0	5	6
165	R:R:L354	R:R:L358	8.3	No	No	0	3	6
166	R:R:E361	R:R:R357	20.93	No	No	0	7	6
167	R:R:L358	R:R:L362	4.15	No	No	0	6	7
168	R:R:F367	R:R:S366	3.96	No	No	0	7	9
169	R:R:F370	R:R:I374	8.79	No	No	0	4	5
170	R:R:V372	R:R:Y376	5.05	No	Yes	0	8	8
171	R:R:F378	R:R:I374	3.77	No	No	0	8	5
172	R:R:C377	R:R:F378	4.19	Yes	No	0	9	8
173	R:R:E382	R:R:N380	14.46	No	No	1	9	9
174	R:R:N380	R:R:V383	5.91	No	No	0	9	9
175	R:R:Q381	R:R:R384	12.85	No	No	0	5	7
176	R:R:A352	R:R:P349	3.74	No	No	0	3	6
177	R:R:F187	R:R:K130	3.72	Yes	No	0	4	5
178	R:R:G369	R:R:S140	3.71	No	No	0	9	9
179	R:R:G251	R:R:V254	3.68	No	No	0	7	3
180	R:R:V261	R:R:W273	3.68	No	Yes	0	5	9
181	R:R:F256	R:R:L252	3.65	Yes	No	0	5	3
182	R:R:F256	R:R:L255	3.65	Yes	No	0	5	3
183	R:R:F345	R:R:L360	3.65	Yes	No	0	6	4
184	R:R:A147	R:R:C377	3.61	No	Yes	0	8	9
185	R:R:A241	R:R:C229	3.61	No	No	0	4	6
186	R:R:P236	R:R:S235	3.56	No	No	0	5	7
187	R:R:L245	R:R:Y226	3.52	No	Yes	0	7	8
188	R:R:A185	R:R:S205	3.42	No	No	0	3	5
189	R:R:I335	R:R:P336	3.39	No	No	0	8	9
190	R:R:I371	R:R:P336	3.39	No	No	0	5	9
191	R:R:G365	R:R:Q368	3.29	No	Yes	0	7	9
192	R:R:C263	R:R:I284	3.27	No	No	0	4	7
193	R:R:S233	R:R:S238	3.26	No	No	0	5	6
194	R:R:S209	R:R:V179	3.23	No	No	0	6	7
195	R:R:S292	R:R:V293	3.23	No	No	0	7	7
196	R:R:G339	R:R:H341	3.18	No	No	0	9	8
197	R:R:T166	R:R:V152	3.17	No	No	0	6	3
198	R:R:C202	R:R:L186	3.17	No	Yes	6	9	6
199	R:R:C272	R:R:L186	3.17	No	Yes	6	9	6
200	R:R:A153	R:R:L154	3.15	No	Yes	0	1	7
201	R:R:A248	R:R:L252	3.15	No	No	0	7	3
202	R:R:I131	R:R:S127	3.1	No	No	0	4	2
203	R:R:I132	R:R:T128	3.04	No	No	0	6	3
204	R:R:I148	R:R:T170	3.04	No	No	0	5	3
205	R:R:L181	R:R:S205	3	No	No	0	5	5
206	R:R:L221	R:R:S292	3	No	No	0	7	7
207	R:R:L230	R:R:S238	3	No	No	0	7	6
208	R:R:L307	R:R:S330	3	No	No	0	8	8
209	R:R:L221	R:R:V295	2.98	No	No	0	7	6
210	R:R:L299	R:R:V295	2.98	No	No	0	8	6
211	R:R:I150	R:R:I387	2.94	No	No	0	8	5
212	R:R:D193	R:R:S198	2.94	No	No	0	2	6
213	R:R:D193	R:R:T192	2.89	No	No	0	2	4
214	R:R:I150	R:R:L151	2.85	No	Yes	0	8	8
215	R:R:I150	R:R:L154	2.85	No	Yes	0	8	7
216	R:R:I374	R:R:L379	2.85	No	No	0	5	5
217	R:R:K182	R:R:L186	2.82	No	Yes	0	6	6
218	R:R:A143	R:R:F370	2.77	No	No	0	6	4
219	R:R:L360	R:R:L364	2.77	No	No	0	4	6
220	R:R:F378	R:R:V146	2.62	No	No	0	8	5
221	R:R:F217	R:R:T213	2.59	Yes	No	0	8	5
222	R:R:F367	R:R:I132	2.51	No	No	0	7	6
223	R:R:F145	R:R:I141	2.51	No	No	0	3	7
224	R:R:S322	R:R:W325	2.47	No	No	0	5	6
225	R:R:F211	R:R:L174	2.44	Yes	No	0	8	6
226	R:R:F187	R:R:L186	2.44	Yes	Yes	0	4	6
227	R:R:L247	R:R:W244	2.28	No	No	0	3	1
228	R:R:R305	R:R:R309	2.13	No	No	0	7	6
229	R:R:R240	R:R:W244	2	No	No	0	5	1
230	R:R:A176	R:R:G177	1.95	No	No	0	8	3
231	R:R:G363	R:R:S366	1.86	No	No	0	5	9
232	R:R:G136	R:R:V135	1.84	No	No	0	8	6
233	R:R:G258	R:R:V261	1.84	No	No	0	1	5
234	R:R:A143	R:R:A373	1.79	No	No	0	6	8
235	R:R:A147	R:R:A373	1.79	No	No	0	8	8
236	R:R:A178	R:R:A208	1.79	No	No	0	6	4
237	R:R:A178	R:R:A212	1.79	No	No	0	6	5
238	R:R:P280	R:R:S279	1.78	No	No	0	2	4
239	R:R:G294	R:R:I343	1.76	No	No	0	4	5
240	R:R:C229	R:R:S238	1.72	No	No	0	6	6
241	R:R:A178	R:R:S209	1.71	No	No	0	6	6
242	R:R:A207	R:R:V261	1.7	No	No	0	6	5
243	R:R:A271	R:R:T199	1.68	No	No	0	3	3
244	R:R:L358	R:R:P359	1.64	No	No	0	6	7
245	R:R:S233	R:R:S235	1.63	No	No	0	5	7
246	R:R:V200	R:R:V204	1.6	No	No	0	4	3
247	R:R:I387	R:R:S388	1.55	No	No	0	5	5
248	R:R:A184	R:R:D183	1.54	No	No	0	3	7
249	R:R:F345	R:R:G353	1.51	Yes	No	0	6	3
250	R:R:P160	R:R:R239	1.44	No	No	0	7	5
251	R:R:K390	R:R:L154	1.41	No	Yes	0	4	7
252	R:R:R156	R:R:T385	1.29	No	No	0	7	5
253	R:R:F345	R:R:L348	1.22	Yes	No	0	6	5
254	R:R:F187	R:R:H188	1.13	Yes	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:H137	6.992	5	4	7
2	R:R:L151	5.465	4	0	8
3	R:R:L154	3.65	5	1	7
4	R:R:L157	5.5625	4	1	8
5	R:R:R161	6.854	5	1	9
6	R:R:N162	6.775	4	1	8
7	R:R:H165	8.27	4	1	9
8	R:R:F169	4.8225	4	0	8
9	R:R:T171	6.0175	4	0	8
10	R:R:F172	10.036	5	0	8
11	R:R:L186	3.406	5	6	6
12	R:R:F187	3.0175	4	0	4
13	R:R:H210	9.0425	4	2	7
14	R:R:F211	5.81	4	0	8
15	R:R:T215	6.7775	4	0	8
16	R:R:F217	9.53	4	0	8
17	R:R:W219	11.77	6	3	9
18	R:R:Y226	7.375	4	0	8
19	R:R:F256	6.6825	4	2	5
20	R:R:W260	9.285	4	2	8
21	R:R:W273	10.4333	6	2	9
22	R:R:Y281	10.945	4	0	3
23	R:R:W282	10.3875	4	2	6
24	R:R:I285	8.985	4	2	7
25	R:R:F300	8.57	5	1	8
26	R:R:L337	11.9025	4	1	9
27	R:R:F338	8.082	5	1	8
28	R:R:Y342	11.01	4	5	8
29	R:R:F345	6.07	6	0	6
30	R:R:Q368	7.985	4	5	9
31	R:R:Y376	10.6275	4	1	8
32	R:R:C377	4.585	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H137	R:R:S366	11.3389	8.37	Yes	No	0	7	9
2	R:R:C377	R:R:F378	10.1075	4.19	Yes	No	0	9	8
3	R:R:C377	R:R:F169	39.1635	4.19	Yes	Yes	0	9	8
4	R:R:F169	R:R:L144	93.616	6.09	Yes	No	0	8	9
5	R:R:I173	R:R:L144	61.1037	5.71	No	No	0	7	9
6	R:R:F145	R:R:I173	59.9477	10.05	No	No	0	3	7
7	R:R:F145	R:R:I141	58.7801	2.51	No	No	0	3	7
8	R:R:F180	R:R:I141	57.5893	3.77	No	No	0	7	7
9	R:R:F180	R:R:H137	55.4575	6.79	No	Yes	0	7	7
10	R:R:F172	R:R:L144	100	4.87	Yes	No	0	8	9
11	R:R:C377	R:R:L151	27.0346	6.35	Yes	Yes	0	9	8
12	R:R:L151	R:R:N162	14.7313	8.24	Yes	Yes	0	8	8
13	R:R:I150	R:R:L151	12.1231	2.85	No	Yes	0	8	8
14	R:R:F172	R:R:L168	31.9663	7.31	Yes	No	0	8	9
15	R:R:L168	R:R:T171	29.422	4.42	No	Yes	0	9	8
16	R:R:T171	R:R:W219	31.1705	6.06	Yes	Yes	0	8	9
17	R:R:V246	R:R:W219	17.3628	7.36	No	Yes	3	5	9
18	R:R:F242	R:R:V246	14.743	6.55	No	No	0	6	5
19	R:R:F172	R:R:N216	31.9663	16.92	Yes	No	0	8	8
20	R:R:N216	R:R:T171	29.422	7.31	No	Yes	0	8	8
21	R:R:F169	R:R:V372	62.463	5.24	Yes	No	0	8	8
22	R:R:V372	R:R:Y376	61.731	5.05	No	Yes	0	8	8
23	R:R:H165	R:R:Y376	22.1319	8.71	Yes	Yes	1	9	8
24	R:R:H165	R:R:R161	10.6012	4.51	Yes	Yes	1	9	9
25	R:R:E223	R:R:H165	19.21	16	No	Yes	1	9	9
26	R:R:E223	R:R:V164	36.4392	9.98	No	No	0	9	8
27	R:R:V164	R:R:Y226	33.8832	3.79	No	Yes	0	8	8
28	R:R:L337	R:R:Y376	31.3738	24.62	Yes	Yes	1	9	8
29	R:R:E223	R:R:L337	19.756	10.6	No	Yes	1	9	9
30	R:R:T171	R:R:T215	25.7682	6.28	Yes	Yes	0	8	8
31	R:R:F172	R:R:Q368	85.5533	10.54	Yes	Yes	0	8	9
32	R:R:H137	R:R:V179	35.318	4.15	Yes	No	4	7	7
33	R:R:S209	R:R:V179	34.6094	3.23	No	No	0	6	7
34	R:R:K182	R:R:S209	28.9166	12.24	No	No	0	6	6
35	R:R:F187	R:R:L186	17.4034	2.44	Yes	Yes	0	4	6
36	R:R:K182	R:R:L186	23.0613	2.82	No	Yes	0	6	6
37	R:R:F187	R:R:H188	11.3389	1.13	Yes	No	0	4	4
38	R:R:W260	R:R:W273	19.4772	4.69	Yes	Yes	2	8	9
39	R:R:H210	R:R:W260	26.3143	13.75	Yes	Yes	2	7	8
40	R:R:H210	R:R:W282	28.6146	11.64	Yes	Yes	2	7	6
41	R:R:K286	R:R:W282	67.993	8.12	No	Yes	0	6	6
42	R:R:D350	R:R:K286	69.9971	12.44	No	No	0	5	6
43	R:R:D350	R:R:R357	71.0892	5.96	No	No	0	5	6
44	R:R:E361	R:R:R357	80.9643	20.93	No	No	0	7	6
45	R:R:E361	R:R:Y342	81.8879	5.61	No	Yes	0	7	8
46	R:R:Q368	R:R:Y342	82.1377	4.51	Yes	Yes	5	9	8
47	R:R:I285	R:R:W260	26.9939	11.74	Yes	Yes	2	7	8
48	R:R:I285	R:R:W282	37.1769	11.74	Yes	Yes	2	7	6
49	R:R:F211	R:R:T215	14.923	7.78	Yes	Yes	0	8	8
50	R:R:I285	R:R:M214	10.5373	5.83	Yes	No	2	7	5
51	R:R:F217	R:R:Y342	27.4586	16.5	Yes	Yes	0	8	8
52	R:R:F217	R:R:S292	24.5658	3.96	Yes	No	0	8	7
53	R:R:A224	R:R:F338	16.1429	8.32	No	Yes	0	8	8
54	R:R:F338	R:R:L337	20.5402	8.53	Yes	Yes	1	8	9
55	R:R:A224	R:R:L299	15.6956	4.73	No	No	0	8	8
56	R:R:L230	R:R:Y226	21.2315	15.24	No	Yes	0	7	8
57	R:R:L299	R:R:N228	13.0235	13.73	No	No	0	8	8
58	R:R:L230	R:R:S238	18.6175	3	No	No	0	7	6
59	R:R:S233	R:R:S238	10.7058	3.26	No	No	0	5	6
60	R:R:K264	R:R:W260	31.1124	6.96	No	Yes	2	7	8
61	R:R:K264	R:R:T278	28.7482	7.51	No	No	0	7	5
62	R:R:T278	R:R:Y281	23.0903	4.99	No	Yes	0	5	3
63	R:R:S292	R:R:V293	12.3555	3.23	No	No	0	7	7
64	R:R:N346	R:R:V293	10.851	14.78	No	No	0	5	7
65	R:R:F300	R:R:F338	10.1307	5.36	Yes	Yes	1	8	8
66	R:R:F333	R:R:Y376	20.0523	4.13	No	Yes	0	8	8
67	R:R:F333	R:R:K329	17.1711	6.2	No	No	0	8	8
68	R:R:K329	R:R:R326	12.704	14.85	No	No	0	8	7
69	R:R:R326	R:R:S330	11.1356	6.59	No	No	0	7	8
70	R:R:F345	R:R:R357	14.4757	14.97	Yes	No	0	6	6
71	R:R:L221	R:R:S292	17.6125	3	No	No	0	7	7
72	R:R:L221	R:R:V295	16.9213	2.98	No	No	0	7	6
73	R:R:L299	R:R:V295	16.4043	2.98	No	No	0	8	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 7V9L_nogp

PDB Summary
PDB	7V9L_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.77
Number of Linked Nodes	235
Number of Links	254
Number of Hubs	32
Number of Links mediated by Hubs	116
Number of Communities	6
Number of Nodes involved in Communities	41
Number of Links involved in Communities	52

Path Summary
Number Of Nodes in MetaPath	74
Number Of Links MetaPath	73
Number of Shortest Paths	37180
Length Of Smallest Path	3
Average Path Length	14.4516
Length of Longest Path	31
Minimum Path Strength	1.365
Average Path Strength	7.46757
Maximum Path Strength	22.045
Minimum Path Correlation	0.7
Average Path Correlation	0.92216
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	48.046
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.7119
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• cytoskeletal protein binding • spectrin binding • protein-containing complex binding • protein binding • binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to stimulus • response to stimulus • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • cellular process • cell population proliferation • regulation of biological process • regulation of cellular process • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • intracellular anatomical structure • cytoplasm • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • organelle • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • synapse • cell junction • cell body • protein binding • binding • G-protein beta-subunit binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cellular process • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • molecular transducer activity • G protein-coupled receptor activity • growth hormone-releasing hormone receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cell surface receptor signaling pathway • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • D2 dopamine receptor binding • adenylate cyclase inhibitor activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • negative regulation of peptide hormone secretion • negative regulation of establishment of protein localization • negative regulation of protein secretion • negative regulation of signaling • negative regulation of cell communication • negative regulation of peptide secretion • negative regulation of cellular process • negative regulation of protein localization • negative regulation of insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • ciliary basal body
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q02643
Sequence	>7V9L_nogp_Chain_R F S T V K I I Y T V G H S I S I V A L F V A I T I L V A L R R L H C P R N Y V H T Q L F T T F I L K A G A V F L K D A A L F H S D D T D H F S T V L C K V S V A A S H F A T M T N F S W L L A E A V Y L N C L L A S T S P S S R R A F W W L V L A G W G L P V L F T G T W V S C K L A F E D I A C W D L D D T S P Y W W I I K G P I V L S V G V N F G L F L N I I R I L V R K L E T Q S Q Y W R L S K S T L F L I P L F G I H Y I I F N F L P D N A G L G I R L P L E L G L G S F Q G F I V A I L Y C F L N Q E V R T E I S R K W Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7V9M	B1	Peptide	Glucagon	GHRH (SV1)	Homo sapiens	Somatoliberin	-	Gs/β1/γ2	3.29	2021-10-20	doi.org/10.1073/pnas.2106606118
	7V9M (No Gprot)	B1	Peptide	Glucagon	GHRH (SV1)	Homo sapiens	Somatoliberin	-		3.29	2021-10-20	doi.org/10.1073/pnas.2106606118
	7V9L	B1	Peptide	Glucagon	GHRH (SV1)	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.6	2022-04-06	doi.org/10.1073/pnas.2106606118
	7V9L (No Gprot)	B1	Peptide	Glucagon	GHRH (SV1)	Homo sapiens	-	-		2.6	2022-04-06	doi.org/10.1073/pnas.2106606118

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Download 7V9L_nogp.zip

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