Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.HN.33 2.0625404
2G.HN.38 0.4925402
3G.hns1.01 7.34134
4G.S1.02 6.9444556
5G.S2.02 1.4892505
6G.S3.03 6.19667658
7G.S3.04 7.789254157
8G.S3.05 5.2155408
9G.S3.06 8.409254157
10G.s3h2.03 5.0275419
11G.H2.01 5.44475419
12G.H2.06 6.58883619
13G.H2.07 5.54429719
14G.H2.10 3.90025418
15G.h2s4.01 10.6723409
16G.S4.04 5.10625409
17G.S4.05 3.6825497
18G.H3.01 3.86583609
19G.H3.09 5.876676169
20G.H3.13 10.50445166
21G.H3.17 10.9088515
22G.S5.05 4.87599
23G.S5.07 3.64699
24G.HG.03 3.59475406
25G.HG.14 2.4705406
26G.HG.16 3.98475404
27G.hgh4.02 3.98475448
28G.hgh4.04 2.5755446
29G.hgh4.05 10.7068506
30G.hgh4.11 3.874545
31G.hgh4.20 4.7346543
32G.hgh4.21 5.985404
33G.H4.03 3.1385404
34G.H4.08 6.2984543
35G.H4.10 11.227447
36G.H4.12 6.5096544
37G.H4.13 5.0838543
38G.H4.14 5.8222545
39G.H4.15 8.402408
40G.h4s6.08 3.29575405
41G.S6.02 10.1602408
42G.S6.05 7.6854545
43G.H5.03 5.0145499
44G.H5.05 5.31625455
45G.H5.08 6.377658
46G.H5.15 3.9026558
47G.H5.17 10.20845175
48G.H5.25 3.5325408
49G.H5.26 3.99525408
50b.1x1 3.0055404
51b.1x4 3.2315408
52b.1x16 1.52825404
53b.b1x6 9.13125439
54b.l1x3 8.398639
55b.l1x6 10.8682519
56b.b2x1 6.0382518
57b.b2x5 6.45017637
58b.b3x3 4.58275408
59b.l3x1 7.24925419
60b.l3x2 6.69865139
61b.b4x6 9.40571739
62b.l4x3 5.6295436
63b.b5x3 5.89171739
64b.b5x7 5.99725407
65b.l5x1 4.68685148
66b.l5x5 9.32509
67b.b6x1 5.50725419
68b.b6x5 4.739406
69b.b7x1 6.134404
70b.b8x4 5.96485146
71b.l8x5 2.64425403
72b.l9x3 7.6278579
73b.l9x6 6.22183618
74b.b10x5 4.91583609
75b.l11x2 7.4646579
76b.b12x6 8.62457778
77b.b13x7 8.1302567
78b.l13x3 8.01283669
79b.l13x6 6.9515419
80b.l13x7 5.12225469
81b.b14x3 4.781465
82b.b15x1 6.90567669
83b.b15x2 7.686416
84b.l15x1 6.32825417
85b.l15x2 6.2282569
86b.b16x4 9.81675466
87b.b16x5 6.08725405
88b.b16x6 8.87614768
89b.b16x7 7.443254219
90b.b17x5 7.7845417
91b.b17x7 8.87475418
92b.l17x3 9.43533619
93b.l17x6 8.0538519
94b.b18x3 4.92225418
95b.b18x5 6.14675415
96b.l18x1 7.251686
97b.l18x2 5.655487
98b.l18x3 8.21025485
99b.b19x2 7.30533616
100b.b19x4 6.2975418
101b.l19x1 6.77875419
102b.l19x2 7.9036519
103b.b20x4 11.3808518
104b.b20x6 7.25133616
105b.b20x7 4.782409
106b.l20x2 7.05725409
107b.b21x1 7.30467617
108b.b21x5 6.13025404
109b.b21x7 6.30883605
110b.b22x5 6.03733687
111b.l22x5 6.863676129
112b.b23x2 5.034486
113b.b23x6 7.5446117
114b.l23x1 5.7762516
115b.l23x2 5.32554118
116b.b24x4 7.75354116
117b.b24x5 3.43825405
118b.b24x6 7.5214118
119b.l24x3 4.93275405
120b.l25x3 9.0844109
121b.l25x6 13.2766518
122b.b27x3 6.01575408
123b.l27x1 11.3554719
124b.l27x2 8.3174109
125b.b28x3 4.594537
126b.b28x4 7.44754106
127b.b28x6 8.6885109
128g.h1x1 2.3325402
129g.l1x2 3.881412
130g.l1x4 6.1996518
131g.h2x9 1.6195404
132g.h2x11 10.3663486
133g.ctx3 5.881836199
134g.ctx6 3.23525406
135g.ctx14 6.3704539
136g.ctx15 7.55125439
137g.ctx16 5.617738
138Lig 7.459461320
1391x39 4.8435407
1401x60 4.76275406
141I1x49 5.89475406
1422x42 6.2018508
1432x46 4.7386529
1442x50 6.7938529
1452x57 5.13875427
1462x60 5.44625426
147E1x50 5.69529728
148E1x52 5.444426
1493x28 5.6998525
1503x32 8.84925427
1513x43 5.54975429
1523x50 8.59725429
153I2x51 7.1466557
154I2x53 6.7095187
1554x50 4.05633629
1564x58 5.10254225
157E2 7.88881024
1585x39 6.13667627
1595x47 8.5815628
1605x50 3.21475409
1615x54 5.60175428
1625x58 5.606629
1635x62 5.718254237
1646x41 3.3985428
1656x44 4.64857729
1666x48 6.508828
1676x51 7.29233627
1686x52 10.6636527
169E3 4.3595402
1707x34 5.065424
1717x38 5.10525426
1727x39 8.0256525
1737x42 7.38357727
1747x45 7.0435429
1757x49 6.7825429
1767x53 5.862529
1778x50 5.67117609
1788x54 3.7354507
179NT 0.76675400
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.b4x7 b.l2x5 10.68716.796NoNo085
2b.l2x5 b.l4x2 27.185618.418NoNo054
3b.l4x2 g.ctx15 27.618813.493NoYes349
4b.l26x5 g.ctx15 49.46426.204NoYes059
5b.l26x5 g.ctx4 65.0695.366NoNo057
6g.ctx3 g.ctx4 65.5144.83YesNo097
7b.l22x2 g.ctx3 1003.873NoYes019
8b.l22x2 g.ctx2 1003.375NoNo013
9g.ctx2 g.h2x15 1004.799NoNo036
10g.h2x11 g.h2x15 10019.492YesNo066
11b.l18x1 g.h2x11 76.15364.435YesYes866
12b.b22x5 b.l18x1 77.701611.683YesYes876
13b.b22x5 b.b23x2 10010.595YesYes876
14b.b21x7 b.b23x2 1003.987YesYes056
15b.b21x7 b.b24x6 10011.189YesYes058
16b.b23x6 b.b24x6 1007.911YesYes1178
17b.b23x6 b.l23x2 1004.485YesYes1178
18b.l21x7 b.l23x2 1005.912NoYes058
19b.l21x7 b.l23x1 1003.734NoYes056
20G.H3.17 b.l23x1 82.94127.704YesYes156
21G.H3.17 b.l27x1 83.26117.123YesYes159
22b.l18x2 g.h2x11 76.14955.56YesYes876
23b.b22x5 b.l18x2 76.36774.189YesYes877
24b.l23x1 b.l25x6 82.936511.436YesYes168
25b.l25x6 b.l27x1 83.260621.89YesYes189
26b.b2x1 b.l27x1 1006.944YesYes189
27G.H2.10 b.b2x1 77.81714.703YesYes188
28G.H2.10 b.l7x2 78.06633.49YesNo089
29G.H2.07 b.l7x2 79.08543.417YesNo099
30G.H2.04 G.H2.07 1008.699NoYes099
31G.H2.04 G.H3.08 1006.902NoNo098
32G.H3.08 G.S4.04 1006.194NoYes089
33G.H3.09 G.S4.04 1005.896YesYes099
34G.H3.09 G.H4.15 1007.93YesYes098
35G.H3.06 G.H4.15 1009.136NoYes068
36G.H3.06 G.H4.14 1003.977NoYes065
37G.H4.10 G.H4.14 1008.396YesYes475
38G.H4.10 G.hgh4.05 10015.969YesYes076
39G.HG.15 G.hgh4.05 10012.055NoYes076
40G.HG.15 G.s4h3.04 1006.165NoNo078
41G.HG.07 G.s4h3.04 1007.404NoNo098
42G.HG.07 G.s4h3.02 1004.284NoNo099
43G.HG.03 G.s4h3.02 1003.903YesNo069
44G.HG.03 G.s5hg.01 1005.358YesNo069
45G.S5.07 G.s5hg.01 1005.178YesNo099
46G.S4.05 G.S5.07 1003.991YesYes979
47G.S4.05 G.S5.05 1003.537YesYes979
48G.H5.07 G.S5.05 1003.951NoYes099
49G.H5.07 G.S4.03 1004.327NoNo097
50G.S1.04 G.S4.03 1004.853NoNo077
51G.S1.04 G.S3.03 1005.724NoYes078
52G.S1.02 G.S3.03 1005.432YesYes568
53b.b2x1 b.b6x1 89.29137.424YesYes189
54b.b6x1 b.l9x6 89.40677.063YesYes198
55G.H2.07 b.l9x6 1004.728YesYes198
56G.S4.04 G.S4.06 1004.194YesNo097
57G.H4.15 G.S4.06 1006.555YesNo087
58G.HG.16 G.hgh4.05 1006.647YesYes046
59G.HG.13 G.HG.16 1004.169NoYes074
60G.HG.07 G.HG.13 1003.519NoNo097
61G.S5.07 G.s6h5.01 1004.825YesNo999
62G.S5.05 G.s6h5.01 1007.004YesNo999
63G.H2.06 b.l9x6 73.37784.06YesYes198
64G.H2.06 b.l17x6 36.57458.576YesYes199
65G.H2.06 b.l19x1 36.51344.839YesYes199
66G.H5.10 G.S6.02 15.362311.608NoYes078
67G.H5.10 G.S6.04 15.973212.607NoNo079
68G.S5.05 G.S6.04 16.16274.3YesNo099
695x68 G.H5.16 11.85637.168NoNo076
70G.H5.15 G.S1.02 1004.243YesYes586
71G.H5.15 G.H5.19 1004.376YesNo088
725x64 G.H5.16 11.00693.569NoNo066
733x54 5x64 10.16944.124NoNo086
74G.H5.19 G.H5.22 1003.711NoNo084
75G.H5.22 G.H5.23 1006.538NoNo044
763x50 G.H5.23 10017.593YesNo094
77b.l17x5 b.l17x6 36.49273.535NoYes169
78b.l17x5 b.l19x2 72.83473.825NoYes169
79b.l17x3 b.l19x2 49.13284.914YesYes199
80b.b19x4 b.l17x3 25.549910.13YesYes189
81b.b19x4 b.b20x6 22.73627.004YesYes186
82b.b17x7 b.b20x6 65.635112.325YesYes186
83b.b17x7 b.b21x1 64.1744.181YesYes187
84b.1x19 b.b21x1 15.39818.576NoYes067
85b.1x15 b.1x19 13.92646.891NoNo076
86b.1x15 g.h1x15 27.11952.435NoNo078
87b.1x14 g.h1x15 25.6471.821NoNo048
88b.1x11 b.1x14 24.91071.729NoNo084
89b.1x11 g.h1x12 17.54742.538NoNo086
90g.h1x12 g.h1x9 16.8112.835NoNo066
91g.h1x5 g.h1x9 15.33823.838NoNo066
92b.1x4 g.h1x5 13.86533.155YesNo086
93b.1x4 b.ntx3 10.18292.386YesNo085
94b.l17x5 b.l19x1 36.46094.711NoYes169
95b.b20x4 b.l17x3 23.100319.41YesYes189
96b.b20x4 b.b20x6 45.46724.382YesYes186
97b.b20x2 b.l19x2 23.341812.862NoYes069
98b.b20x2 b.b20x4 23.09957.373NoYes068
99b.b21x1 g.l1x4 15.029911.673YesYes178
100b.1x15 g.l1x4 13.92954.762NoYes078
101g.ctx3 g.ctx6 11.16575.7YesYes096
102g.ctx3 g.ctx5 71.59673.665YesNo1999
103b.lhb1x11 g.ctx5 71.15283.955NoNo049
104b.b25x7 b.lhb1x11 70.2634.381NoNo074
105b.b25x7 b.b28x6 45.352917.425NoYes079
106b.b28x4 b.b28x6 20.88856.844YesYes1069
107b.b28x5 g.ctx16 14.27724.395NoYes358
108b.b1x6 b.b4x6 11.154320.842YesYes399
109b.b24x3 b.b25x7 24.46555.714NoNo057
110b.b24x3 b.b27x3 23.1293.549NoYes058
111b.b27x3 b.l25x3 36.45167.94YesYes089
112b.l25x3 b.l27x2 52.00095.924YesYes1099
113b.b27x3 b.b28x6 23.1298.005YesYes089
114b.b28x4 b.l25x3 18.22528.384YesYes1069
115b.b3x2 b.b4x6 11.15065.694NoYes359
116b.b2x5 b.b3x2 11.595910.135YesNo375
117b.b21x1 g.h1x14 32.74673.117YesNo079
118b.b17x6 g.h1x14 18.39847.621NoNo079
119b.b16x4 b.b17x6 18.030612.163YesNo067
120b.b16x4 b.b16x6 13.24488.7YesYes668
121b.b15x1 b.b16x6 11.764512.629YesYes698
122g.h1x10 g.h1x14 13.98076.627NoNo099
123b.b17x3 g.h1x10 13.61296.409NoNo059
124b.b16x6 b.b17x3 13.2458.228YesNo685
125b.l26x3 b.l26x5 15.16246.79NoNo075
126b.l26x1 b.l26x3 14.26996.938NoNo377
127b.b2x5 b.l26x1 13.824611.403YesNo377
128b.l2x3 b.l2x5 16.07954.525NoNo085
129b.b3x1 b.l2x3 15.63313.935NoNo058
130b.b3x1 b.b6x5 15.18663.985NoYes056
131b.b3x3 b.b6x5 13.84725.554YesYes086
132b.b3x3 b.b4x5 11.16783.687YesNo087
133b.b4x5 b.b5x5 10.27487.292NoNo075
134b.b13x7 b.b16x6 12.518217.04YesYes678
135b.b13x5 b.b13x7 10.31015.189NoYes047
136b.l25x4 b.l27x2 49.32695.853NoYes059
137I1x49 b.l25x4 46.66924.788YesNo065
1383x32 3x36 21.10113.977YesNo277
1393x36 6x48 51.0594.694NoYes278
1406x44 6x48 1006.014YesYes298
1413x43 6x44 86.37984.626YesYes299
1423x43 7x53 87.41455.861YesYes299
1433x50 7x53 94.36366.994YesYes299
1445x54 6x44 86.557.214YesYes289
1455x54 5x58 86.71064.43YesYes289
1463x50 5x58 90.59045.041YesYes299
1475x47 6x44 33.73773.752YesYes289
1485x47 6x52 30.37623.041YesYes287
1496x52 Lig 59.06627.562YesYes270
1506x48 6x52 30.37956.616YesYes287
1513x36 Lig 29.54496.408NoYes270
1526x48 6x51 51.47993.308YesYes287
1536x51 Lig 29.540413.152YesYes270
1543x33 Lig 23.661710.122NoYes060
155E2 Lig 27.041910.675YesYes240
1567x42 Lig 52.28513.818YesYes270
1573x32 7x42 13.072610.719YesYes277
1587x38 7x42 13.07897.848YesYes267
1596x51 7x38 13.4944.061YesYes276
1601x39 7x39 35.361112.3YesYes075
1617x39 7x42 40.42712.278YesYes257
1621x43 2x57 10.13944.664NoYes067
1632x57 7x42 30.4155.584YesYes277
1641x46 2x57 17.74385.42NoYes077
1651x46 7x47 10.13946.238NoNo076
1661x52 8x54 11.90746.454NoYes077
1678x50 8x54 21.27184.181YesYes097
1688x50 I1x50 34.648511.205YesNo099
169I1x49 I1x50 35.98618.999YesNo069
1704x57 4x58 10.14114.49NoYes2275
1713x33 4x57 15.21184.8NoNo067
1721x35 2x65 20.1540.463NoNo055
1731x35 1x39 25.22311.325NoYes057
1745x36 5x39 10.14092.511NoYes057
1752x65 NT 15.08490.502NoYes050
176b.b1x6 b.b28x5 13.83123.997YesNo395
177g.ctx15 g.ctx16 16.05324.477YesYes398
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
3x32Lig13.5462YesYes7010
3x33Lig10.1220NoYes6010
3x36Lig6.4082NoYes7010
E2Lig10.6752YesYes4010
5x43Lig7.890NoYes7010
5x461Lig4.5130NoYes6010
6x51Lig13.1522YesYes7010
6x52Lig7.5622YesYes7010
6x55Lig7.9632NoYes6010
7x42Lig3.8182YesYes7010
2x563x327.1552NoYes8721
2x567x425.6382NoYes8721
2x577x394.8872YesYes7522
2x577x425.5842YesYes7721
2x607x395.1042YesYes6522
2x607x425.82YesYes6721
3x26E23.9630NoYes6421
3x323x363.9772YesNo7711
3x327x4210.7192YesYes7711
3x334x574.80NoNo6712
3x335x394.5940NoYes6712
3x366x484.6942NoYes7812
3x375x4617.1950NoNo6621
4x60E24.5942NoYes6421
4x605x399.1792NoYes6722
4x61E28.9942NoYes5421
4x63E210.0210NoYes4421
E2E210.7262YesYes4411
5x39E28.5812YesYes7421
E2E2x517.6612YesNo4512
5x395x4311.5742YesNo7721
5x446x525.810NoYes7721
5x446x554.9170NoNo7621
5x476x483.3092YesYes8822
5x476x5223.0412YesYes8721
6x486x513.3082YesYes8721
6x486x526.6162YesYes8721
6x516x5210.2892YesYes7711
6x516x557.372YesNo7611
6x517x345.5742YesYes7412
6x517x384.0612YesYes7611
7x347x384.0622YesYes4621
7x387x427.8482YesYes6711
7x397x4212.2782YesYes5721
7x38Lig4.452YesYes6010
E2x52Lig3.9370NoYes5010
4x64E22.9470NoYes5421
3x29Lig2.9370NoYes5010

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
92.31Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
92.31Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
85.71Single6H7JIsoprenaline6H7J-β1-Isoprenaline
85.71Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
85.71Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
85.71Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
84.62Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
84.62Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
84.62Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
84.62Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
84.62Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
84.62Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
84.62Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
84.62Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
84.62Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
84.62Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
84.62Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
84.62Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
84.62Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
84.62Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
84.62Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
80.00Single4LDEBI1671074LDE-β2-BI167107
78.57Single2RH1S-Carazolol2RH1-β2-S-Carazolol
78.57Single2Y03Isoprenaline2Y03-β1-Isoprenaline
78.57Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
78.57Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
78.57Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
78.57Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
78.57Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
78.57Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
78.57Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
78.57Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
78.57Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
78.57Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
78.57Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
78.57Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
78.57Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
78.57Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
78.57Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
78.57Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
78.57Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
78.57Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
78.57Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
78.57Consensusamine_offonOrthosteric Ligandamine_off amine_on
78.57Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
78.57Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
78.57Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
78.57Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
78.57Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
78.57Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
78.57Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
78.57Consensustrace-amine_onOrthosteric Ligandta1_on
76.92Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
76.92Single6PS0S-Carazolol6PS0-β2-S-Carazolol
76.92Single6PS4ICI118-5516PS4-β2-ICI118-551
76.92Single6PS5S-Propranolol6PS5-β2-S-Propranolol
76.92Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
76.92Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
76.92Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
76.92Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
76.92Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
76.92Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
76.92Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
76.92Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
76.92Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
76.92Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
76.92Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
76.92Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
76.92Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
76.92Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
76.92Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
76.92Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
76.92Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
76.92Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
76.92Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
76.92Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
75.00Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
75.00Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
73.33Single2YDVNECA2YDV-A2A-NECA
73.33Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
73.33Single4UHRCGS216804UHR-A2A-CGS21680
73.33Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
73.33Single5D5AS-Carazolol5D5A-β2-S-Carazolol
73.33Single5D5BS-Carazolol5D5B-β2-S-Carazolol
73.33Single5G53NECA5G53-A2A-NECA-Gs
73.33Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
73.33Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
73.33Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
73.33Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
73.33Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
73.33Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
73.33Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
73.33Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
73.33Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
73.33Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
73.33Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
73.33Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
73.33Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
73.33Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
73.33Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
73.33Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
73.33Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
73.33Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
71.43Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
71.43Single2Y04Salbutamol2Y04-β1-Salbutamol
71.43Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
71.43Single3NY8ICI118-5513NY8-β2-ICI118-551
71.43Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
71.43Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
71.43Single4GBRS-Carazolol4GBR-β2-S-Carazolol
71.43Single6H7MSalbutamol6H7M-β1-Salbutamol
71.43Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
71.43Single6PS1Timolol6PS1-β2-Timolol
71.43Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
71.43Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
71.43Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
71.43Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
71.43Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
71.43Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
71.43Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
71.43Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
71.43Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
71.43Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
71.43Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
71.43Single8JJOAlprenolol8JJO-β2-Alprenolol
71.43Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
71.43Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
71.43Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
71.43Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
71.43Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
71.43Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
71.43Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
71.43Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
71.43Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
71.43Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
71.43Single9CHXS-Carazolol9CHX-β2-S-Carazolol
71.43Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
71.43Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
71.43Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
71.43Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
71.43Consensusdopamine_offOrthosteric Ligandd2_off d3_off
71.43Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
70.59Single3NY9ICI118-5513NY9-β2-ICI118-551
70.59Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
69.23Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
69.23Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
69.23Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
69.23Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
69.23Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
69.23Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
69.23Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
69.23Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
69.23Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
69.23Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
69.23Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
69.23Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
69.23Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
69.23Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
69.23Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
69.23Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
69.23Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
69.23Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
69.23Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
69.23Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
69.23Consensusalpha2_offOrthosteric Ligandalpha2c_off
69.23Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
68.75Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
68.75Single3D4STimolol3D4S-β2-Timolol
68.75Single4AMIBucindolol4AMI-β1-Bucindolol
68.75Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
68.75Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
68.75Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
68.75Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
68.75Single8JJ8Formoterol8JJ8-β2-Formoterol
68.75Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
68.75Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
68.75Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
68.75Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
68.75Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
68.75Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
66.67Single2YCWS-Carazolol2YCW-β1-S-Carazolol
66.67Single5D6LS-Carazolol5D6L-β2-S-Carazolol
66.67Single5JQHS-Carazolol5JQH-β2-S-Carazolol
66.67Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
66.67Single6E67BI1671076E67-β2-BI167107-Gs (fused)
66.67Single7WC6LSD7WC6-5-HT2A-LSD
66.67Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
66.67Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
66.67Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
66.67Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
66.67Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
66.67Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
66.67Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
66.67Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
66.67Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
66.67Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
64.71Single6H7LDobutamine6H7L-β1-Dobutamine
64.71Single6IBLArformoterol6IBL-β1-Arformoterol
64.71Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
64.71Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
64.71Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
64.71Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
64.71Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
64.71Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
64.29Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
64.29Single6TPGEMPA6TPG-OX2-EMPA
64.29Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
64.29Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
64.29Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
64.29Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
64.29Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
64.29Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
64.29Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
64.29Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
64.29Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
64.29Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
64.29Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
64.29Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
64.29Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
64.29Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
64.29Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
64.29Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
64.29Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
64.29Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
64.29Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
64.29Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
64.29Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
64.29Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
64.29Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
64.29Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
64.29Consensusalpha1_onOrthosteric Ligandalpha1a_on
64.29Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
64.29Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
64.29Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
62.50Single3P0GBI1671073P0G-β2-BI167107
62.50Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
62.50Single6J21Aprepitant6J21-NK1-Aprepitant
62.50Single6TQ7SB-3348676TQ7-OX1-SB-334867
62.50Single6WGTLSD6WGT-5-HT2A-LSD
62.50Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
62.50Single8E0GBU728E0G-μ-BU72
62.50Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
62.50Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
61.54Single3PBLEticlopride3PBL-D3-Eticlopride
61.54Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
61.54Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
61.54Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
61.54Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
61.54Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
61.54Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
61.54Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
61.54Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
61.54Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
61.54Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
61.54Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
61.54Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
61.11Single4UG2CGS216804UG2-A2A-CGS21680
60.00Single2Y02Carmoterol2Y02-β1-Carmoterol
60.00Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
60.00Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
60.00Single4QKX35V4QKX-β2-35V
60.00Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
60.00Single7BU7BI1671077BU7-β1-BI167107
60.00Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
60.00Single7UL4Alvimopan7UL4-μ-Alvimopan
60.00Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
60.00Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
60.00Single7WC7Lisuride7WC7-5-HT2A-Lisuride
60.00Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
60.00Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
60.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
60.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
60.00Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
60.00Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
60.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
60.00Single8X64Desloratadine8X64-H1-Desloratadine
60.00Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
60.00Consensus5ht5_onOrthosteric Ligand5ht5a_on
60.00Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
60.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
60.00Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
60.00Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
60.00Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
60.00Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
60.00Consensusalpha2_onOrthosteric Ligandalpha2b_on
60.00Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
60.00Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
60.00Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
60.00Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
58.82Single4RWADIPP-NH24RWA-δ-DIPP-NH2
58.82Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
58.82Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
58.82Single6MXTSalmeterol6MXT-β2-Salmeterol
58.82Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
58.82Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
58.82Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
58.82Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
58.82Single7YITNalfurafine7YIT-κ-Nalfurafine
58.82Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
58.82Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
58.82Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
58.82Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
58.82Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
58.82Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
58.82Consensusalpha1_offOrthosteric Ligandalpha1a_off
58.82Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
58.82Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
58.82Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
58.82Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
57.89Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
57.89Single4IARErgotamine4IAR-5-HT1B-Ergotamine
57.89Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
57.89Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
57.89Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
57.89Single8WDTphotoNECA8WDT-A2A-photoNECA
57.89Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
57.89Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
57.89Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
57.14Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
57.14Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
57.14Single6TODEMPA6TOD-OX1-EMPA-Na
57.14Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
57.14Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
57.14Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
57.14Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
57.14Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
57.14Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
57.14Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
57.14Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
57.14Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
57.14Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
57.14Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
57.14Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
57.14Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
56.25Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
56.25Single5C1MBU725C1M-μ-BU72
56.25Single5TVNLSD5TVN-5-HT2B-LSD
56.25Single5WIUNemonapride5WIU-D4-Nemonapride
56.25Single5WIVNemonapride5WIV-D4-Nemonapride-Na
56.25Single5WQCEMPA5WQC-OX2-EMPA
56.25Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
56.25Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
56.25Single6PS6Timolol6PS6-β2-Timolol
56.25Single7C61Ergotamine7C61-5-HT1B-Ergotamine
56.25Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
56.25Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
56.25Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
56.25Single8JXSPF-61428JXS-D1-PF-6142
56.25Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
56.25Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
55.56Single5X93K-87945X93-ETB-K-8794
55.56Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
55.56Single7UM4AS26747237UM4-5-HT5A-AS2674723
55.56Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
55.56Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
55.56Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
55.56Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
55.56Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
55.56Consensusendothelin_offOrthosteric Ligandetb_off
55.56Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
55.00Single6HLOAprepitant6HLO-NK1-Aprepitant
55.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
53.85Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
53.85Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
53.85Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
53.85Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
53.85Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
53.33Single2YDOAdenosine2YDO-A2A-Adenosine
53.33Single4ZJCSB-6740424ZJC-OX1-SB-674042
53.33Single6A94Zotepine6A94-5-HT2A-Zotepine
53.33Single6KUXRS-799486KUX-α2a-RS-79948
53.33Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
53.33Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
53.33Single6TPNHTL66416TPN-OX2-HTL6641
53.33Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
53.33Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
53.33Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
53.33Single7UL3Famotidine7UL3-H2-Famotidine
53.33Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
53.33Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
53.33Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
53.33Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
53.33Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
53.33Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
53.33Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
53.33Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
53.33Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
53.33Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
53.33Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
52.94Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
52.94Single4U15Tiotropium4U15-M3-Tiotropium
52.94Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
52.94Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
52.94Single6J20Aprepitant6J20-NK1-Aprepitant
52.94Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
52.94Single6OL9Tiotropium6OL9-M5-Tiotropium
52.94Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
52.94Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
52.94Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
52.94Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
52.94Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
52.94Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
52.94Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
52.94Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
52.94Single8XVLZibotentan8XVL-ETA-Zibotentan
52.94Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
52.94Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
52.94Consensusa2_onOrthosteric Liganda2b_on
52.94Consensusa2_on_gpOrthosteric Liganda2b_on_gp
52.94Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
52.94Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
52.94Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
52.94Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
52.94Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
52.94Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
52.94Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
52.94Consensustachykinin_offOrthosteric Ligandnk1_off
52.63Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
52.63Single8X5YAstemizole8X5Y-H1-Astemizole
52.63Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
52.63Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
52.38Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
50.00Single2Y01Dobutamine2Y01-β1-Dobutamine
50.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
50.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
50.00Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
50.00Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
50.00Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
50.00Single5CXVTiotropium5CXV-M1-Tiotropium
50.00Single5DHGC-355DHG-NOP-C-35
50.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
50.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
50.00Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
50.00Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
50.00Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
50.00Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
50.00Single6TOTLemborexant6TOT-OX1-Lemborexant
50.00Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
50.00Single7SRQLSD7SRQ-5-HT2B-LSD
50.00Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
50.00Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
50.00Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
50.00Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
50.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
50.00Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
50.00Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
50.00Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
50.00Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single8JJLOlodaterol8JJL-β2-Olodaterol
50.00Single8JXRLSD8JXR-D1-LSD
50.00Single8T1WCVN4248T1W-GPR6-CVN424
50.00Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
50.00Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
50.00Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
50.00Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
50.00Single8X63Mepyramine8X63-H1-Mepyramine
50.00Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
50.00Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
50.00Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
50.00Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
50.00Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
50.00Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
50.00Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
50.00Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
50.00Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
50.00Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
50.00Consensusa3_onOrthosteric Liganda3a_on
50.00Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
50.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
50.00Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
50.00Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
50.00Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
50.00Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
50.00Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
50.00Consensushistamine_offOrthosteric Ligandh1_off
50.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
50.00Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
47.83Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
47.83Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
47.62Single3QAKUK-4320973QAK-A2A-UK-432097
47.62Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
47.37Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
47.37Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
47.37Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
47.37Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
47.37Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
47.37Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
47.37Single7EZCUKA7EZC-A2A-UKA
47.37Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
47.37Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
47.37Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
47.37Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
47.37Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
47.37Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
47.37Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
47.37Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
47.37Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
47.37Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
47.37Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
47.06Single2Y00Dobutamine2Y00-β1-Dobutamine
47.06Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
47.06Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
47.06Single5XPRBosentan5XPR-ETB-Bosentan
47.06Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
47.06Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
47.06Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
47.06Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
47.06Single6TP6Filorexant6TP6-OX1-Filorexant
47.06Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
47.06Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
47.06Single7W41PD1762527W41-BB2-PD176252
47.06Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
47.06Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
47.06Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
47.06Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
47.06Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
47.06Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
47.06Single8ZMFA1L108ZMF-5-HT2C-A1L10
47.06Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
47.06Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
47.06Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
47.06Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
47.06Consensusa3_on_gpOrthosteric Liganda3a_on_gp
47.06Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
47.06Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
47.06Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
47.06Consensusbombesin_offOrthosteric Ligandbb2_off
47.06Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
47.06Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
47.06Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
46.67Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
46.67Single5WS3EMPA5WS3-OX2-EMPA
46.67Single6AKXA4R6AKX-CCR5-A4R
46.67Single6B73MP11046B73-κ-MP1104
46.67Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
46.67Single6ME2Ramelteon6ME2-MT1-Ramelteon
46.67Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
46.67Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
46.67Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
46.67Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
46.67Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
46.67Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
46.67Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
46.67Single8IWESpermidine8IWE-TA9-Spermidine
46.67Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
46.67Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
46.67Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
46.67Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
46.67Consensusorexin_offOrthosteric Ligandox2_off ox1_off
46.67Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
46.67Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
46.15Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
46.15Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
46.15Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
46.15Single9CHUNoradrenaline9CHU-β2-Noradrenaline
46.15Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
46.15Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
45.83Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
45.45Single5WF5UK-4320975WF5-A2A-UK-432097
45.45Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
45.45Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
45.45Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
45.00Single5WF6UK-4320975WF6-A2A-UK-432097
45.00Single5ZTYAM102575ZTY-CB2-AM10257
45.00Single6PT3DPI-2876PT3-δ-DPI-287
45.00Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
45.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
45.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
45.00Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
45.00Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
45.00Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
45.00Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
44.44Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
44.44Single4DJHJDTic4DJH-κ-JDTic
44.44Single5V54Methiothepin5V54-5-HT1B-Methiothepin
44.44Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
44.44Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
44.44Single6E59L-7607356E59-NK1-L-760735
44.44Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
44.44Single7B6WCyclazosin7B6W-α1b-Cyclazosin
44.44Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
44.44Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
44.44Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
44.44Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
44.44Single8EA0Iperoxo8EA0-M3-Iperoxo
44.44Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
44.44Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
44.44Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
44.44Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
44.44Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
44.44Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
44.44Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
44.44Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
44.44Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
44.44Consensus5ht1_offOrthosteric Ligand5ht1b_off
44.44Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
44.44Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
44.44Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
44.00Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
44.00Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
43.75Single3RZECidoxepin3RZE-H1-Cidoxepin
43.75Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
43.75Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
43.75Single4MBSMaraviroc4MBS-CCR5-Maraviroc
43.75Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
43.75Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
43.75Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
43.75Single6IQLL7458706IQL-D4-L745870
43.75Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
43.75Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
43.75Single6V9SGTPL114036V9S-OX1-GTPL11403
43.75Single6VI4JDTic6VI4-κ-JDTic
43.75Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
43.75Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
43.75Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
43.75Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
43.75Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
43.75Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
43.75Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
43.75Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
43.75Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
43.75Single8K5CAcipimox8K5C-HCA2-Acipimox
43.75Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
43.75Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
43.75Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
43.75Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
43.75Single9BJKNaloxone9BJK-μ-Naloxone-NAM
43.75Consensushca_onOrthosteric Ligandhca2_on
43.48Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
43.48Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
43.48Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
43.48Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
43.48Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
43.48Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
42.86Single3UZAGTPL92363UZA-A2A-GTPL9236
42.86Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
42.86Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
42.86Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
42.86Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
42.86Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
42.86Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
42.86Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
42.86Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
42.86Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
42.86Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
42.86Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
42.86Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
42.86Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
42.86Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
42.86Consensus5ht2_onOrthosteric Ligand5ht2b_on
42.86Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
42.86Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
42.86Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
42.86Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
42.86Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
42.11Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
42.11Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
42.11Single6CM4Risperidone6CM4-D2-Risperidone
42.11Single6ZG4HTL00099366ZG4-M1-HTL0009936
42.11Single7DFPSpiperone7DFP-D2-Spiperone
42.11Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
42.11Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
42.11Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
42.11Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
42.11Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
42.11Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
42.11Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
42.11Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
42.11Single8JWY2-1188JWY-A2A-2-118
42.11Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
42.11Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
42.11Single8XYIVUF106618XYI-CXCR3-VUF10661
42.11Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
42.11Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
42.11Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
42.11Consensuslpa_offOrthosteric Ligandlpa1_off
42.11Consensusorexin_onOrthosteric Ligandox2_on
42.11Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
42.11Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
42.11Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
42.11Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
41.18Single4DAJTiotropium4DAJ-M3-Tiotropium
41.18Single4MQSIperoxo4MQS-M2-Iperoxo
41.18Single4U14Tiotropium4U14-M3-Tiotropium
41.18Single5DHHSB-6121115DHH-NOP-SB-612111
41.18Single5DSGTiotropium5DSG-M4-Tiotropium
41.18Single6DRXLisuride6DRX-5-HT2B-Lisuride
41.18Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
41.18Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
41.18Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
41.18Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
41.18Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
41.18Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
41.18Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
41.18Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
41.18Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
41.18Single8CU6LJ-45178CU6-A2A-LJ-4517
41.18Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
41.18Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
41.18Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
41.18Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
41.18Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
41.18Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
41.18Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
41.18Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
41.18Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
41.18Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
41.18Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
41.18Consensushca_on_gpOrthosteric Ligandhca2_on_gp
41.18Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
41.18Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
41.18Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
40.91Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
40.91Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
40.91Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
40.91Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
40.91Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
40.91Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
40.74Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
40.74Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
40.74Consensusbombesin_onOrthosteric Ligandbb2_on
40.74Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
40.74Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
40.00Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
40.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
40.00Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
40.00Single6HLLCP999946HLL-NK1-CP99994
40.00Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
40.00Single6TP4ACT-4622066TP4-OX1-ACT-462206
40.00Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
40.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
40.00Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
40.00Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
40.00Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
40.00Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
40.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
40.00Single8K5BNiacin8K5B-HCA2-Niacin
40.00Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
40.00Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
40.00Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
40.00Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
40.00Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
40.00Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
40.00Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
40.00Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
40.00Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
40.00Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
39.13Single6PT2KGCHM076PT2-δ-KGCHM07
39.13Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
39.13Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
39.13Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
39.13Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
39.13Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
39.13Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
39.13Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
38.89Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
38.89Single6HLPNetupitant6HLP-NK1-Netupitant
38.89Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
38.89Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
38.89Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
38.89Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
38.89Single7SINNPS-21437SIN-CaS-NPS-2143
38.89Single7SINNPS-21437SIN-CaS-NPS-2143
38.89Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
38.89Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
38.89Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
38.89Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
38.89Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
38.89Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
38.89Single8S4DCMF-0198S4D-Apelin-CMF-019
38.89Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
38.89Single8TF5Oleic acid8TF5-GPR6-Oleic acid
38.89Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
38.89Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
38.89Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
38.89Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
38.89Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
38.89Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
38.89Consensusadenosine_offOrthosteric Liganda1_off a2_off
38.89Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
38.89Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
38.89Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
38.46Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
38.46Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
38.46Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
38.46Single8PWNTheophylline8PWN-A2A-Theophylline
38.46Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
38.46Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
38.10Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
38.10Single7SK9CCX6627SK9-ACKR3-CCX662
38.10Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
38.10Single7XN9L-054,5227XN9-SST2-L-054,522
38.10Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
38.10Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
38.10Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
37.50Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
37.50Single4S0VSuvorexant4S0V-OX2-Suvorexant
37.50Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
37.50Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
37.50Single6AKYMaraviroc6AKY-CCR5-Maraviroc
37.50Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
37.50Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
37.50Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
37.50Single6TPJSuvorexant6TPJ-OX2-Suvorexant
37.50Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
37.50Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
37.50Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
37.50Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
37.50Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
37.50Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
37.50Single7XRRLemborexant7XRR-OX2-Lemborexant
37.50Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
37.50Single8GNGIstradefylline8GNG-A2A-Istradefylline
37.50Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
37.50Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
37.50Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
37.50Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
37.50Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
37.50Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
37.50Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
37.50Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
37.50Single8Y0HVUF114188Y0H-CXCR3-VUF11418
37.50Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
37.50Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
37.50Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
37.50Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
37.50Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
37.50Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
37.50Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
37.50Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
37.50Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
37.50Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
37.04Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
36.84Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
36.84Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
36.84Single5XR8AM8415XR8-CB1-AM841
36.84Single5XRAAM115425XRA-CB1-AM11542
36.84Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
36.84Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
36.84Single7TUYGSK682753A7TUY-GPR183-GSK682753A
36.84Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
36.84Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
36.84Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
36.84Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
36.84Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
36.84Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
36.84Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
36.84Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
36.84Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
36.84Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
36.84Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
36.84Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
36.84Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
36.84Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
36.84Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
36.84Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
36.36Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
36.36Single7F8XNN90567F8X-CCKA-NN9056
36.36Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
36.36Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
36.36Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
36.36Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
36.36Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
36.36Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
36.36Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
36.36Consensuslpl_onOrthosteric Ligands1p_on lpa_on
36.36Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
36.36Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
36.36Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
36.00Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
36.00Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
36.00Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
36.00Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
35.71Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
35.71Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
35.71Single8A2OTheophylline8A2O-A2A-Theophylline-Na
35.71Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
35.71Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
35.71Consensussensory_onOrthosteric Ligandopsins_on
35.29Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
35.29Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
35.29Single5IU7Q274563465IU7-A2A-Q27456346-Na
35.29Single5IUBQ274563445IUB-A2A-Q27456344-Na
35.29Single5JTBZM-2413855JTB-A2A-ZM-241385
35.29Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
35.29Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
35.29Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
35.29Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
35.29Single6AQFZM-2413856AQF-A2A-ZM-241385
35.29Single6TP3Nemorexant6TP3-OX1-Nemorexant
35.29Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
35.29Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
35.29Single7AROLUF58337ARO-A2A-LUF5833-Na
35.29Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
35.29Single7T32ZM-2413857T32-A2A-ZM-241385
35.29Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
35.29Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
35.29Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
35.29Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
35.29Single8IHKAcifran8IHK-HCA3-Acifran
35.29Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
35.29Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
35.29Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
35.29Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
35.29Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
35.29Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
35.29Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
35.29Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.29Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
35.29Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
35.29Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
35.29Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
35.29Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
35.29Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
35.29Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
35.29Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
35.29Consensusa2_offOrthosteric Liganda2a_off
35.29Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
35.29Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
35.29Consensusopsins_offOrthosteric Ligandrhodopsin_off
35.29Consensussensory_offOrthosteric Ligandopsins_off
35.00Single6A93Risperidone6A93-5-HT2A-Risperidone
35.00Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
35.00Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
35.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
35.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
35.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
35.00Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
35.00Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
35.00Single8JWZAB9288JWZ-A2A-AB928-Na
35.00Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.00Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
35.00Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
35.00Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
35.00Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
35.00Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
35.00Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
35.00Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
35.00Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
35.00Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
35.00Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
35.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
35.00Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
34.78Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
34.78Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
34.78Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
34.78Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
34.62Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
34.62Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
34.62Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
33.33Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
33.33Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
33.33Single3EMLZM-2413853EML-A2A-ZM-241385
33.33Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
33.33Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
33.33Single4YAYZD-71554YAY-AT1-ZD-7155
33.33Single5IU8Q274563475IU8-A2A-Q27456347-Na
33.33Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
33.33Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
33.33Single5TGZAM65385TGZ-CB1-AM6538
33.33Single5UENDU1725UEN-A1-DU172
33.33Single5UIGCmpd-15UIG-A2A-Cmpd-1
33.33Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
33.33Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
33.33Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
33.33Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
33.33Single6ME5Agomelatine6ME5-MT1-Agomelatine
33.33Single6S0LZM-2413856S0L-A2A-ZM-241385
33.33Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
33.33Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
33.33Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
33.33Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
33.33Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
33.33Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
33.33Single7PYRPSB-21157PYR-A2A-PSB-2115
33.33Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
33.33Single7V3ZCP559407V3Z-CB1-CP55940
33.33Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
33.33Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
33.33Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
33.33Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
33.33Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
33.33Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
33.33Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
33.33Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
33.33Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
33.33Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
33.33Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
33.33Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
33.33Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
33.33Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
33.33Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
33.33Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
33.33Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
33.33Single8K5DGSK2560738K5D-HCA2-GSK256073
33.33Single8RLNLUF58348RLN-A2A-LUF5834
33.33Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
33.33Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
33.33Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
33.33Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
33.33Single8XVJMacitentan8XVJ-ETA-Macitentan
33.33Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
33.33Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
33.33Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
33.33Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
33.33Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
33.33Single9IYAONO-97105319IYA-GPR55-ONO-9710531
33.33Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
33.33Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
33.33Consensusangiotensin_onOrthosteric Ligandat1_on
33.33Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
33.33Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
33.33Consensuscck_onOrthosteric Ligandccka_on cckb_on
33.33Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
33.33Consensuschemerin_onOrthosteric Ligandcml1_on
33.33Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
33.33Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
33.33Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
33.33Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
33.33Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
33.33Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
33.33Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
33.33Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
33.33Consensusprostanoid_offOrthosteric Ligandep_off dp_off
33.33Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
33.33Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
32.14Single6IGLIRL16206IGL-ETB-IRL1620
32.14Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
32.14Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
32.14Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
32.14Consensusbradykinin_onOrthosteric Ligandbk2_on
32.14Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
32.14Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
32.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
32.00Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
32.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
32.00Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
32.00Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
32.00Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
32.00Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
32.00Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
32.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
32.00Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
32.00Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
32.00Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
32.00Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
32.00Consensusvasop-oxy_onOrthosteric Ligandv2_on
32.00Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
31.82Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
31.82Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
31.82Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
31.82Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
31.82Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
31.82Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
31.82Single8QJ2pN1628QJ2-MC4-pN162-Gs
31.82Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
31.82Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
31.82Consensuskisspeptin_onOrthosteric Ligandkiss1_on
31.82Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
31.82Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
31.58Single5IUAQ274563485IUA-A2A-Q27456348-Na
31.58Single5N2RPSB-365N2R-A2A-PSB-36-Na
31.58Single5N2SPSB365N2S-A1-PSB36
31.58Single6D26Fevipiprant6D26-DP2-Fevipiprant
31.58Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
31.58Single6LUQHaloperidol6LUQ-D2-Haloperidol
31.58Single6S0QZM-2413856S0Q-A2A-ZM-241385
31.58Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
31.58Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
31.58Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
31.58Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
31.58Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
31.58Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
31.58Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
31.58Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
31.58Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
31.58Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
31.58Single8GNEKW-63568GNE-A2A-KW-6356-Na
31.58Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
31.58Single8QOTNanobody-E8QOT-μ-Nanobody-E
31.58Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
31.58Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
31.58Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
31.58Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
31.58Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
31.58Consensusdp_offOrthosteric Liganddp2_off
31.58Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
31.58Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
31.58Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
31.58Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
31.58Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
31.58Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
31.58Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
31.58Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
31.58Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
31.25Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
31.25Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
31.25Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
31.25Single3OE9IT1t3OE9-CXCR4-IT1t
31.25Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
31.25Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
31.25Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
31.25Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
31.25Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
31.25Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
31.25Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
31.25Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
31.25Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
31.25Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
31.25Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
31.25Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
31.03Single5GLHEndothelin-15GLH-ETB-Endothelin-1
31.03Single6IGKEndothelin-36IGK-ETB-Endothelin-3
31.03Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
30.77Single5MZPCaffeine5MZP-A2A-Caffeine-Na
30.77Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
30.77Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
30.77Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
30.77Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
30.77Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
30.77Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
30.77Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
30.77Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
30.77Single8ZRTET-18ZRT-ETB-ET-1
30.77Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
30.77Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
30.43Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
30.43Single7QA8Peptide7QA8-STE2-Peptide
30.43Single7QA8Peptide7QA8-STE2-Peptide
30.43Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
30.43Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
30.43Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
30.43Single8IEBA1LYA8IEB-GPR156-A1LYA
30.43Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
30.43Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
30.43Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
30.43Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
30.43Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
30.43Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
30.43Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
30.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
30.00Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
30.00Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
30.00Single7FEECP559407FEE-CB1-CP55940-ZCZ011
30.00Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
30.00Single7PX4PSB-21137PX4-A2A-PSB-2113
30.00Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
30.00Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
30.00Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
30.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
30.00Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
30.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
30.00Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
30.00Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
30.00Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
30.00Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
30.00Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
30.00Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
30.00Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
30.00Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
30.00Consensuslpa_onOrthosteric Ligandlpa1_on
30.00Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
30.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
30.00Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
29.63Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
29.63Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
29.63Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
29.63Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
29.63Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
29.63Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
29.63Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
29.41Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
29.41Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
29.41Single3PWHZM-2413853PWH-A2A-ZM-241385
29.41Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
29.41Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
29.41Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
29.41Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
29.41Single6DS0Ly2660976DS0-5-HT2B-Ly266097
29.41Single6ME9Ramelteon6ME9-MT2-Ramelteon
29.41Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
29.41Single7F8ULintitript7F8U-CCKA-Lintitript
29.41Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
29.41Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
29.41Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
29.41Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
29.41Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
29.41Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
29.41Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
29.41Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
29.41Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
29.41Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
29.41Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
29.41Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
29.41Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
29.41Consensusangiotensin_offOrthosteric Ligandat1_off
29.41Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
29.41Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
29.17Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
29.17Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
29.17Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
29.17Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
29.17Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
29.17Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
29.17Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
29.17Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
29.17Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
29.17Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
29.17Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
29.17Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
29.17Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
29.03Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
28.57Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
28.57Single4N4WSANT-14N4W-SMO-SANT-1
28.57Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
28.57Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
28.57Single6KQICP559406KQI-CB1-CP55940-Org27569
28.57Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
28.57Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
28.57Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single7K15MKD0467K15-BLT1-MKD046-Na
28.57Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
28.57Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
28.57Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
28.57Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
28.57Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
28.57Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
28.57Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
28.57Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
28.57Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
28.00Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
28.00Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
28.00Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
28.00Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
28.00Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
27.78Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
27.78Single3REYXAC3REY-A2A-XAC
27.78Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
27.78Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
27.78Single5UVIZM-2413855UVI-A2A-ZM-241385
27.78Single6MH8ZM-2413856MH8-A2A-ZM-241385
27.78Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
27.78Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
27.78Single6TPKRetosiban6TPK-OT-Retosiban
27.78Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
27.78Single6ZG9GSK10347026ZG9-M1-GSK1034702
27.78Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
27.78Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
27.78Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
27.78Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
27.78Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
27.78Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
27.78Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
27.78Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
27.78Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
27.78Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
27.78Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
27.78Consensusvasop-oxy_offOrthosteric Ligandot_off
27.59Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
27.59Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
27.59Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
27.27Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
27.27Single6K1QIRL25006K1Q-ETB-IRL2500
27.27Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
27.27Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
27.27Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
27.27Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
27.27Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
27.27Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
27.27Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
27.27Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
27.27Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
26.92Single6JODAngiotensin II6JOD-AT2-Angiotensin II
26.92Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
26.92Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
26.92Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
26.92Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
26.92Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
26.92Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.92Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
26.92Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
26.92Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
26.92Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
26.92Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
26.67Single3RFMCaffeine3RFM-A2A-Caffeine
26.67Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
26.67Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
26.67Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
26.67Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
26.67Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
26.67Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
26.67Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
26.67Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
26.67Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
26.32Single6GPSMK08126GPS-CCR2-MK0812
26.32Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
26.32Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
26.32Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
26.32Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
26.32Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
26.32Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
26.32Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
26.32Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
26.32Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
26.32Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
26.32Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
26.32Consensusblt_onOrthosteric Ligandblt1_on
26.32Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
26.32Consensuscck_offOrthosteric Ligandccka_off
26.32Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
26.32Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
26.32Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
26.32Consensusleukotriene_onOrthosteric Ligandblt_on
26.32Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
26.09Single5EE7MK08935EE7-Glucagon-MK0893
26.09Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
26.09Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
26.09Single8IEIA1LYA8IEI-GPR156-A1LYA
26.09Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
26.09Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
26.09Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
25.93Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
25.93Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
25.93Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
25.93Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
25.93Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.93Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
25.93Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
25.93Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
25.93Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
25.93Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
25.93Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
25.81Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
25.81Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
25.81Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
25.81Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
25.00Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
25.00Single3OE6IT1t3OE6-CXCR4-IT1t
25.00Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
25.00Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
25.00Single4XT1Fractalkine4XT1-US28-Fractalkine
25.00Single5CGCHTL142425CGC-mGlu5-HTL14242
25.00Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
25.00Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
25.00Single6GPXMK08126GPX-CCR2-MK0812
25.00Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
25.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
25.00Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
25.00Single7C4SS1P7C4S-S1P3-S1P
25.00Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
25.00Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
25.00Single7WC5Psilocin7WC5-5-HT2A-Psilocin
25.00Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
25.00Single8IEIA1LYA8IEI-GPR156-A1LYA
25.00Single8IEPA1LYA8IEP-GPR156-A1LYA
25.00Single8IEPA1LYA8IEP-GPR156-A1LYA
25.00Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
25.00Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
25.00Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
25.00Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
25.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
25.00Single8WKYPG-9348WKY-MC4-PG-934
25.00Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
25.00Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
25.00Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
25.00Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
25.00Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
25.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
25.00Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
25.00Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
25.00Consensusblt_offOrthosteric Ligandblt1_off
25.00Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
25.00Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
25.00Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
25.00Consensusgi_sensoryOrthosteric Ligandgi_opsins
25.00Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
25.00Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
25.00Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
25.00Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
25.00Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
25.00Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
25.00Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
24.24Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
24.14Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
24.14Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
24.14Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
24.14Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
24.14Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
24.14Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
24.14Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
24.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
24.00Single8IEBA1LYA8IEB-GPR156-A1LYA
24.00Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
24.00Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
24.00Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
24.00Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
24.00Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
24.00Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
23.81Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
23.81Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
23.81Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
23.81Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
23.81Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
23.81Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
23.81Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
23.81Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
23.81Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
23.81Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
23.81Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
23.81Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
23.81Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
23.81Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
23.81Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
23.81Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
23.81Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
23.81Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
23.81Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
23.81Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
23.81Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
23.53Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
23.53Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
23.53Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
23.53Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
23.53Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
23.53Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
23.53Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
23.53Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
23.53Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.53Single9B9Y7DY9B9Y-CB1-7DY
23.53Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
23.33Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
23.33Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
23.33Consensusendothelin_onOrthosteric Ligandetb_on eta_on
23.33Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
23.33Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
23.08Single3OE0CVX153OE0-CXCR4-CVX15
23.08Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
23.08Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
23.08Single6W25SHU91196W25-MC4-SHU9119-Ca
23.08Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
23.08Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
23.08Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
23.08Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
23.08Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
23.08Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
23.08Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
23.08Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
22.86Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
22.86Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
22.73Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
22.73Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
22.73Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
22.73Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
22.73Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
22.73Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
22.73Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
22.73Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
22.73Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
22.73Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
22.73Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
22.73Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
22.73Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
22.73Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
22.22Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
22.22Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
22.22Single3ODUIT1t3ODU-CXCR4-IT1t
22.22Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
22.22Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
22.22Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
22.22Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
22.22Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
22.22Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
22.22Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
22.22Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
22.22Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
22.22Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
22.22Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
22.22Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
22.22Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
22.22Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
22.22Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
22.22Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
22.22Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
22.22Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
22.22Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
22.22Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
22.22Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
22.22Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
22.22Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
21.88Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
21.88Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
21.88Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
21.74Single5CGDHTL142425CGD-mGlu5-HTL14242
21.74Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
21.74Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
21.74Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
21.74Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
21.74Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
21.43Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
21.43Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
21.43Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
21.43Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
21.43Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
21.43Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
21.43Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
21.43Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
21.43Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
21.05Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
21.05Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
21.05Single7VODCariprazine7VOD-5-HT2A-Cariprazine
21.05Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
21.05Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
21.05Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
21.05Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.05Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
21.05Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
21.05Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
20.83Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
20.83Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
20.83Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
20.83Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
20.83Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
20.83Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
20.83Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
20.83Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
20.83Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
20.83Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
20.69Single4XT3Fractalkine4XT3-US28-Fractalkine
20.69Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
20.69Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
20.69Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
20.69Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
20.69Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
20.69Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
20.69Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
20.59Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
20.59Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
20.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
20.00Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
20.00Single6D27CAY104716D27-DP2-CAY10471
20.00Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
20.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
20.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
20.00Single6IIVDaltroban6IIV-TP-Daltroban
20.00Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
20.00Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
20.00Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
20.00Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
20.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
20.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
20.00Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
20.00Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
20.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7WC4Serotonin7WC4-5-HT2A-Serotonin
20.00Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
20.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
20.00Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
20.00Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
20.00Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
20.00Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
20.00Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
20.00Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
20.00Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
20.00Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
20.00Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
20.00Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
20.00Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
19.51Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
19.35Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
19.35Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
19.35Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
19.35Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
19.35Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
19.35Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
19.35Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
19.35Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
19.35Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
19.35Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
19.35Single8IY6Endothelin-18IY6-ETB-Endothelin-1
19.35Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
19.23Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
19.23Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
19.23Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
19.23Single7XNACYN1548067XNA-SST2-CYN154806
19.23Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
19.23Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
19.23Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
19.23Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
19.23Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
19.23Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
19.05Single4NTJAZD12834NTJ-P2Y12-AZD1283
19.05Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
19.05Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
19.05Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
19.05Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
19.05Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
19.05Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
19.05Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
19.05Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
19.05Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
19.05Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.05Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
19.05Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
19.05Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
19.05Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
19.05Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
19.05Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
19.05Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
19.05Consensusep_offOrthosteric Ligandep4_off
18.75Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
18.75Single3OE8IT1t3OE8-CXCR4-IT1t
18.75Single6TQ9SB-4081246TQ9-OX1-SB-408124
18.75Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
18.75Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
18.52Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
18.52Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.52Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
18.52Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
18.52Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
18.52Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
18.52Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
18.52Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
18.52Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
18.18Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
18.18Single5TZRMK86665TZR-FFA1-MK8666
18.18Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
18.18Single7P2L4YI7P2L-mGlu5-4YI
18.18Single7R0CAVP7R0C-V2-AVP-Arrestin2
18.18Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
18.18Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
18.18Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
18.18Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
18.18Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
18.18Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
18.18Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
18.18Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
18.18Single9BJKNAM9BJK-μ-Naloxone-NAM
18.18Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
18.18Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
17.86Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
17.86Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
17.86Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
17.86Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
17.86Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
17.86Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
17.86Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
17.86Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
17.65Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
17.65Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
17.65Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.65Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
17.65Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
17.65Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
17.39Single4PY02MeSATP4PY0-P2Y12-2MeSATP
17.39Single4XEENeurotensin4XEE-NTS1-Neurotensin
17.39Single4XESNeurotensin4XES-NTS1-Neurotensin
17.39Single5X33BIIL2605X33-BLT1-BIIL260
17.39Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
17.39Single6IIURamatroban6IIU-TP-Ramatroban
17.39Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
17.39Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
17.39Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
17.39Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
17.39Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
17.39Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
17.39Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
17.39Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
17.24Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
17.24Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
17.14Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single4BUONeurotensin4BUO-NTS1-Neurotensin
16.67Single5L7IVismodegib5L7I-SMO-Vismodegib
16.67Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
16.67Single6FJ3PTH6FJ3-PTH1-PTH
16.67Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
16.67Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
16.67Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
16.67Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
16.67Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
16.67Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
16.67Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
16.67Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
16.67Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
16.67Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
16.67Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
16.67Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
16.67Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
16.67Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
16.67Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
16.67Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
16.67Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
16.67Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
16.67Consensusgq_nucleotideOrthosteric Ligandgq_p2y
16.67Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
16.13Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
16.13Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
16.13Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
16.13Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
16.13Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
16.13Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
16.13Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
16.13Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
16.00Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
16.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
16.00Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.00Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
16.00Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single5U09Taranabant5U09-CB1-Taranabant
15.79Single5ZKQABT-4915ZKQ-PAF-ABT-491
15.79Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
15.79Single7BR3Elagolix7BR3-GnRH1-Elagolix
15.79Single7F8YDevazepide7F8Y-CCKA-Devazepide
15.79Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
15.79Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
15.79Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
15.79Single9BA0A1AKN9BA0-CB1-A1AKN
15.79Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
15.79Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
15.79Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
15.62Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
15.62Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
15.38Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
15.38Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
15.38Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
15.38Single8KIGSHU91198KIG-MC3-SHU9119-Ca
15.38Consensussomatostatin_offOrthosteric Ligandsst2_off
15.15Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
15.00Single6FFIMMPEP6FFI-mGlu5-MMPEP
15.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
15.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
15.00Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
15.00Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
15.00Single8K2WAMG4878K2W-CXCR3-AMG487
15.00Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
15.00Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
15.00Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
15.00Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
15.00Consensusgrh_offOrthosteric Ligandgnrh1_off
14.81Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
14.81Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
14.81Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
14.81Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
14.71Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
14.71Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
14.29Single4QIMANTA XV4QIM-SMO-ANTA XV
14.29Single6FFHFenobam6FFH-mGlu5-Fenobam
14.29Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
14.29Single7F83PF-051904577F83-Ghrelin-PF-05190457
14.29Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
14.29Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
14.29Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
14.29Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
14.29Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
14.29Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
14.29Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
14.29Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
14.29Single9B9ZA1AKO9B9Z-CB1-A1AKO
14.29Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
14.29Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
14.29Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
13.89Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
13.89Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
13.79Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
13.79Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
13.64Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
13.64Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
13.64Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
13.33Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
13.33Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
13.33Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
13.33Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
13.33Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
13.33Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
13.04Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
13.04Single4BV0Neurotensin4BV0-NTS1-Neurotensin
13.04Single5V56TC1145V56-SMO-TC114
13.04Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
13.04Single7F1TMIP-1a7F1T-CCR5-MIP-1a
13.04Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
13.04Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
13.04Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
13.04Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
13.04Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
13.04Consensusneurotensin_onOrthosteric Ligandnts1_on
13.04Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
13.04Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
12.90Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
12.90Single7SK3CXCL127SK3-ACKR3-CXCL12
12.90Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
12.50Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
12.50Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
12.50Single6OS2TRV0266OS2-AT1-TRV026
12.50Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
12.50Single6YVRNTS8-136YVR-NTS1-NTS8-13
12.50Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
12.50Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
12.50Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
12.50Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
12.50Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
12.50Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
12.50Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
12.50Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
12.50Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
12.50Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
12.50Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
12.50Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
12.50Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
12.50Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
12.50Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
12.50Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
12.50Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
12.50Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
12.50Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
12.12Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
12.12Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
12.00Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
12.00Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
12.00Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
12.00Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
12.00Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
12.00Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
12.00Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
12.00Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.00Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
11.76Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
11.54Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
11.54Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
11.54Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
11.54Single8XQJJN2418XQJ-Apelin-JN241
11.54Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
11.54Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
11.54Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
11.43Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
11.43Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
11.11Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
11.11Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
11.11Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
11.11Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
11.11Single7V6A-7V6A-M4-PubChem 9864275-Gi1/β1/γ2
11.11Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
11.11Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
11.11Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
11.11Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
10.81Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
10.71Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
10.71Single7SK5CXCL127SK5-ACKR3-CXCL12
10.71Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
10.71Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
10.53Single6LI0C176LI0-GPR52-C17
10.53Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
10.53Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
10.53Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
10.53Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
10.53Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
10.53Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
10.34Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
10.00Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
10.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
10.00Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
10.00Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
10.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
10.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
10.00Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
10.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
9.68Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
9.52Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
9.52Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
9.52Single6ZINSR486926ZIN-NTS1-SR48692
9.52Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
9.52Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
9.52Single7VV6C48/807VV6-MRGPRX2-C48/80
9.52Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
9.09Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
9.09Single5T04Neurotensin5T04-NTS1-Neurotensin
9.09Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
9.09Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
9.09Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
9.09Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
9.09Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
9.09Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
9.09Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
9.09Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
9.09Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
9.09Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
8.70Single4JKVTaladegib4JKV-SMO-Taladegib
8.70Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
8.70Single6Z4SSR486926Z4S-NTS1-SR48692
8.70Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
8.70Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
8.70Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
8.70Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
8.70Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
8.33Single5V57TC1145V57-SMO-TC114
8.33Single6OS1TRV0266OS1-AT1-TRV026
8.33Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
8.00Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
8.00Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.00Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.00Single8XQJJN2418XQJ-Apelin-JN241
8.00Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
7.89Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
7.69Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
7.69Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
7.69Single8XVUCXCL28XVU-CXCR2-CXCL2
7.69Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
7.41Single6KNMJN241-96KNM-Apelin-JN241-9
7.41Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
7.41Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
7.41Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
7.14Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
7.14Single8XWNCXCL88XWN-CXCR2-CXCL8
6.90Single7SHEPI; PE7SHE-GPR158-PI; PE
6.67Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
6.25Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
5.88Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
5.88Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.56Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
5.56Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
5.56Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
5.56Consensusp2y_offOrthosteric Ligandp2y1_off
5.26Single4XNWMRS25004XNW-P2Y1-MRS2500
5.26Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.26Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
5.26Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
5.26Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
5.26Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
5.26Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
5.00Single4O9RCyclopamine4O9R-SMO-Cyclopamine
5.00Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
5.00Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
5.00Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
5.00Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
5.00Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single4BWBNeurotensin4BWB-NTS1-Neurotensin
4.76Single4QINSAG1.54QIN-SMO-SAG1.5
4.76Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
4.76Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
4.76Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
4.76Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
4.76Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
4.76Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
4.76Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
4.76Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
4.76Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
4.55Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
4.55Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
4.55Single8IYXYL-3658IYX-GPR34-YL-365
4.55Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
4.35Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
4.35Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
4.35Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
4.35Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
4.35Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
4.17Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
4.17Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.00Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
4.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
4.00Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
3.85Single7SHEPI; PE7SHE-GPR158-PI; PE
3.85Single8XWACXCL18XWA-CXCR2-CXCL1
3.85Single8XWMCXCL68XWM-CXCR2-CXCL6
3.85Single8XWSCXCL58XWS-CXCR2-CXCL5
3.85Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
3.70Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.70Single8XWFCXCL38XWF-CXCR2-CXCL3
3.70Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
3.57Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
3.45Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
3.45Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
3.45Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
3.33Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7

Consensus Members
Id Members
7F0T 7F0T-D1-Dopamine-Gs/β1/γ2
7CKW 7CKW-D1-Fenoldopam-Gs/β1/γ2
7CKY 7CKY-D1-PW0464-Gs/β1/γ2
8IRV 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
8IRR 8IRR-D1-Rotigotine-Gs/β1/γ2
7JV5 7JV5-D1-SKF81297-Gs/β1/γ2
7JVP 7JVP-D1-SKF83959-Gs/β1/γ2
7X2D 7X2D-D1-Tavapadon-Gs/β1/γ2
7CKX 7CKX-D1-A77636-Gs/β1/γ2
7JVQ 7JVQ-D1-Apomorphine-Gs/β1/γ2
Net Summary
Imin 3.299
Number of Linked Nodes 918
Number of Links 1101
Number of Hubs 179
Number of Links mediated by Hubs 684
Number of Communities 23
Number of Nodes involved in Communities 231
Number of Links involved in Communities 341
Path Summary
Number Of Nodes in MetaPath 178
Number Of Links MetaPath 177
Number of Shortest Paths 40490587
Length Of Smallest Path 3
Average Path Length 128
Length of Longest Path 82
Minimum Path Strength 0.322
Average Path Strength 8.01121
Maximum Path Strength 21.2135
Minimum Path Correlation 0.7
Average Path Correlation 1
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.33333
Average % Of Corr. Nodes 36.2464
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 79.5163
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
gs_aminegs_5ht
gs_adrenergic
gs_dopamine
gs_histamine
gs_trace-amine



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download gs_dopamine.zip



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