psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	A:A:D11	A:A:Q12	3.92	No	No	0	2	2
2	A:A:D11	A:A:N14	8.08	No	No	0	2	3
3	A:A:Q12	A:A:R13	16.35	No	No	0	2	4
4	A:A:E16	A:A:R13	6.98	Yes	No	0	4	4
5	A:A:K17	A:A:R13	8.66	No	No	0	4	4
6	A:A:E16	A:A:Q19	5.1	Yes	Yes	2	4	4
7	A:A:E16	A:A:R20	10.47	Yes	No	0	4	3
8	A:A:E16	B:B:T86	7.06	Yes	Yes	2	4	6
9	A:A:Q19	B:B:D83	6.53	Yes	Yes	2	4	8
10	A:A:Q19	B:B:T86	11.34	Yes	Yes	2	4	6
11	A:A:Q19	B:B:N88	15.85	Yes	No	2	4	7
12	A:A:E27	A:A:N23	9.2	No	No	2	6	7
13	A:A:N23	B:B:N88	12.26	No	No	2	7	7
14	A:A:N23	B:B:K89	5.6	No	Yes	2	7	9
15	A:A:I26	B:B:K89	4.36	No	Yes	0	9	9
16	A:A:E27	B:B:K89	6.75	No	Yes	2	6	9
17	A:A:K28	A:A:Q29	5.42	No	No	0	4	4
18	A:A:K32	A:A:Q29	9.49	No	No	0	4	4
19	A:A:D33	A:A:Q29	5.22	No	No	0	5	4
20	A:A:L30	B:B:K78	4.23	No	Yes	0	5	8
21	A:A:K34	A:A:Q31	12.2	Yes	No	0	4	4
22	A:A:D33	B:B:K78	4.15	No	Yes	0	5	8
23	A:A:K34	A:A:Q35	4.07	Yes	Yes	0	4	3
24	A:A:K34	A:A:R38	3.71	Yes	Yes	2	4	4
25	A:A:K34	B:B:L55	8.46	Yes	Yes	2	4	6
26	A:A:Q35	R:R:S261	4.33	Yes	No	0	3	7
27	A:A:Q35	R:R:E262	11.47	Yes	No	0	3	6
28	A:A:Q35	R:R:Q263	3.84	Yes	No	0	3	5
29	A:A:R38	A:A:Y37	9.26	Yes	Yes	2	4	4
30	A:A:R42	A:A:Y37	18.52	No	Yes	0	9	4
31	A:A:Y37	B:B:L55	7.03	Yes	Yes	2	4	6
32	A:A:R38	B:B:L55	4.86	Yes	Yes	2	4	6
33	A:A:R38	R:R:E262	4.65	Yes	No	0	4	6
34	A:A:H220	A:A:T40	4.11	Yes	No	0	7	7
35	A:A:F219	A:A:H41	6.79	Yes	No	0	8	6
36	A:A:H41	A:A:T242	8.21	No	No	0	6	8
37	A:A:H41	A:A:I383	5.3	No	No	0	6	8
38	A:A:I245	A:A:L43	5.71	No	No	0	7	7
39	A:A:F238	A:A:L44	19.49	Yes	No	0	9	9
40	A:A:I244	A:A:L44	4.28	No	No	0	8	9
41	A:A:L45	A:A:M221	9.9	No	No	0	8	8
42	A:A:D223	A:A:L45	6.79	No	No	0	9	8
43	A:A:F246	A:A:L46	4.87	Yes	No	0	9	8
44	A:A:G206	A:A:S205	3.71	No	No	1	8	7
45	A:A:S205	B:B:N119	4.47	No	Yes	1	7	9
46	A:A:G206	B:B:N119	5.09	No	Yes	1	8	9
47	A:A:F222	A:A:I207	5.02	Yes	No	1	7	9
48	A:A:I207	B:B:W99	3.52	No	Yes	1	9	9
49	A:A:F208	A:A:G225	4.52	No	No	0	5	9
50	A:A:E209	A:A:K211	14.85	No	No	1	9	4
51	A:A:E209	A:A:H220	9.85	No	Yes	1	9	7
52	A:A:E209	A:A:F222	5.83	No	Yes	1	9	7
53	A:A:M221	A:A:T210	6.02	No	No	0	8	7
54	A:A:H220	A:A:K211	10.48	Yes	No	1	7	4
55	A:A:F212	A:A:F219	11.79	No	Yes	0	9	8
56	A:A:F212	A:A:M221	4.98	No	No	0	9	8
57	A:A:F212	A:A:I372	3.77	No	No	0	9	8
58	A:A:K216	A:A:Q213	13.56	No	No	0	4	3
59	A:A:N218	A:A:Q213	15.85	No	No	0	4	3
60	A:A:R373	A:A:V214	6.54	Yes	No	15	5	6
61	A:A:F376	A:A:V214	13.11	Yes	No	15	8	6
62	A:A:D215	A:A:R373	11.91	No	Yes	15	5	5
63	A:A:D215	A:A:F376	8.36	No	Yes	15	5	8
64	A:A:F219	A:A:V217	3.93	Yes	No	0	8	5
65	A:A:F219	A:A:F376	8.57	Yes	Yes	0	8	8
66	A:A:C379	A:A:F219	5.59	No	Yes	0	8	8
67	A:A:F222	A:A:H220	6.79	Yes	Yes	1	7	7
68	A:A:F222	B:B:W99	19.04	Yes	Yes	1	7	9
69	A:A:V224	A:A:W234	9.81	No	Yes	0	9	9
70	A:A:Q227	A:A:W234	5.48	Yes	Yes	1	9	9
71	A:A:Q227	B:B:L117	6.65	Yes	Yes	1	9	9
72	A:A:Q227	B:B:N119	3.96	Yes	Yes	1	9	9
73	A:A:Q227	B:B:G144	4.93	Yes	No	1	9	8
74	A:A:Q227	B:B:Y145	6.76	Yes	Yes	1	9	8
75	A:A:E230	A:A:R228	8.14	No	No	0	9	9
76	A:A:R228	B:B:T164	5.17	No	No	0	9	6
77	A:A:R228	B:B:D186	4.76	No	No	0	9	9
78	A:A:E230	A:A:R232	5.82	No	No	0	9	8
79	A:A:R231	A:A:W234	11	No	Yes	0	9	9
80	A:A:R232	B:B:C204	5.57	No	Yes	1	8	7
81	A:A:R232	B:B:D228	14.29	No	Yes	1	8	9
82	A:A:K233	B:B:Y145	3.58	Yes	Yes	1	9	8
83	A:A:K233	B:B:M188	10.08	Yes	No	1	9	8
84	A:A:K233	B:B:C204	4.85	Yes	Yes	1	9	7
85	A:A:K233	B:B:D228	8.3	Yes	Yes	1	9	9
86	A:A:K233	B:B:N230	4.2	Yes	No	1	9	9
87	A:A:K233	B:B:D246	5.53	Yes	Yes	1	9	9
88	A:A:I235	A:A:W234	3.52	No	Yes	0	9	9
89	A:A:F238	A:A:W234	4.01	Yes	Yes	0	9	9
90	A:A:W234	B:B:L117	4.56	Yes	Yes	1	9	9
91	A:A:W234	B:B:Y145	4.82	Yes	Yes	1	9	8
92	A:A:I235	A:A:L282	4.28	No	No	0	9	9
93	A:A:Q236	A:A:W281	5.48	No	Yes	1	8	5
94	A:A:Q236	B:B:R314	7.01	No	Yes	1	8	8
95	A:A:C237	A:A:F238	4.19	No	Yes	0	8	9
96	A:A:C237	B:B:Y59	5.38	No	Yes	1	8	8
97	A:A:C237	B:B:M101	4.86	No	Yes	1	8	9
98	A:A:F238	A:A:V241	3.93	Yes	No	0	9	9
99	A:A:F238	B:B:W99	13.03	Yes	Yes	0	9	9
100	A:A:D240	A:A:N239	4.04	No	No	1	6	8
101	A:A:N239	B:B:K57	6.99	No	Yes	1	8	9
102	A:A:N239	B:B:W332	7.91	No	Yes	1	8	9
103	A:A:D240	B:B:K57	11.06	No	Yes	1	6	9
104	A:A:D240	B:B:W99	4.47	No	Yes	1	6	9
105	A:A:I244	A:A:T285	4.56	No	No	0	8	7
106	A:A:F246	A:A:V248	5.24	Yes	No	0	9	7
107	A:A:F246	A:A:L272	6.09	Yes	No	0	9	8
108	A:A:F246	A:A:F273	7.5	Yes	Yes	0	9	9
109	A:A:N292	A:A:V247	4.43	Yes	No	0	9	7
110	A:A:L291	A:A:V248	4.47	No	No	0	8	7
111	A:A:F345	A:A:V248	7.87	Yes	No	0	8	7
112	A:A:N264	A:A:Y311	9.3	No	No	0	9	6
113	A:A:K293	A:A:R265	3.71	No	No	0	9	9
114	A:A:I341	A:A:L266	8.56	No	No	0	8	8
115	A:A:E344	A:A:L270	5.3	Yes	No	0	5	6
116	A:A:F345	A:A:L270	8.53	Yes	No	0	8	6
117	A:A:I276	A:A:L272	4.28	No	No	0	8	8
118	A:A:F273	A:A:W277	8.02	Yes	Yes	7	9	6
119	A:A:F273	A:A:V287	5.24	Yes	No	7	9	6
120	A:A:F273	A:A:L289	4.87	Yes	No	7	9	9
121	A:A:F273	A:A:F345	8.57	Yes	Yes	7	9	8
122	A:A:F273	A:A:I348	7.54	Yes	No	7	9	4
123	A:A:F273	A:A:S349	3.96	Yes	No	7	9	7
124	A:A:C359	A:A:F273	4.19	No	Yes	7	5	9
125	A:A:D274	A:A:N278	4.04	No	No	0	5	8
126	A:A:D274	A:A:I348	8.4	No	No	0	5	4
127	A:A:V287	A:A:W277	4.9	No	Yes	7	6	6
128	A:A:I348	A:A:W277	3.52	No	Yes	7	4	6
129	A:A:S349	A:A:W277	11.12	No	Yes	7	7	6
130	A:A:H357	A:A:W277	25.39	No	Yes	0	7	6
131	A:A:N279	A:A:W281	4.52	No	Yes	0	8	5
132	A:A:L282	A:A:N279	12.36	No	No	0	9	8
133	A:A:K280	A:A:W281	9.28	No	Yes	1	5	5
134	A:A:K280	B:B:D290	4.15	No	Yes	1	5	6
135	A:A:W281	B:B:D290	7.82	Yes	Yes	1	5	6
136	A:A:W281	B:B:R314	16.99	Yes	Yes	1	5	8
137	A:A:W281	B:B:W332	8.43	Yes	Yes	1	5	9
138	A:A:R283	A:A:R356	13.86	No	Yes	0	3	2
139	A:A:D284	A:A:R356	5.96	No	Yes	0	4	2
140	A:A:I382	A:A:S286	9.29	No	No	0	6	8
141	A:A:F290	A:A:I288	3.77	Yes	Yes	0	9	9
142	A:A:D378	A:A:I288	9.8	No	Yes	0	7	9
143	A:A:L289	A:A:L291	4.15	No	No	0	9	8
144	A:A:F345	A:A:L289	9.74	Yes	No	7	8	9
145	A:A:F290	A:A:H362	7.92	Yes	No	16	9	9
146	A:A:F290	A:A:T364	5.19	Yes	Yes	16	9	9
147	A:A:F290	A:A:N371	7.25	Yes	No	16	9	9
148	A:A:F290	A:A:R374	6.41	Yes	Yes	16	9	4
149	A:A:F363	A:A:L291	3.65	Yes	No	0	5	8
150	A:A:N292	A:A:T364	4.39	Yes	Yes	0	9	9
151	A:A:E309	A:A:I308	4.1	No	No	0	4	7
152	A:A:I308	A:A:Y311	4.84	No	No	0	7	6
153	A:A:D310	A:A:E309	3.9	No	No	0	3	4
154	A:A:F312	A:A:F340	7.5	Yes	Yes	23	8	7
155	A:A:E344	A:A:F312	3.5	Yes	Yes	23	5	8
156	A:A:E314	A:A:F340	4.66	No	Yes	0	6	7
157	A:A:F315	A:A:R336	16.03	No	No	0	6	5
158	A:A:F315	A:A:F340	19.29	No	Yes	0	6	7
159	A:A:P321	A:A:Y318	4.17	No	No	0	5	6
160	A:A:F340	A:A:Y318	9.28	Yes	No	0	7	6
161	A:A:D343	A:A:Y318	5.75	No	No	0	3	6
162	A:A:P321	A:A:T320	5.25	No	No	0	5	1
163	A:A:T320	A:A:Y339	3.75	No	Yes	0	1	3
164	A:A:D323	A:A:E322	9.09	No	No	0	4	1
165	A:A:A324	A:A:Y339	5.34	No	Yes	0	3	3
166	A:A:P326	A:A:T325	5.25	No	No	0	1	2
167	A:A:E330	A:A:P326	6.29	Yes	No	0	3	1
168	A:A:P326	A:A:T335	8.74	No	No	0	1	4
169	A:A:D331	A:A:P332	4.83	No	No	0	4	1
170	A:A:D331	A:A:R333	8.34	No	No	0	4	5
171	A:A:D331	A:A:V334	7.3	No	No	0	4	4
172	A:A:K338	A:A:T335	6.01	No	No	0	5	4
173	A:A:K338	A:A:Y339	3.58	No	Yes	13	5	3
174	A:A:F363	A:A:K338	16.13	Yes	No	13	5	5
175	A:A:F363	A:A:Y339	8.25	Yes	Yes	13	5	3
176	A:A:E344	A:A:F340	16.32	Yes	Yes	23	5	7
177	A:A:L346	A:A:R342	4.86	No	No	13	4	4
178	A:A:P361	A:A:R342	12.97	No	No	13	5	4
179	A:A:F363	A:A:R342	12.83	Yes	No	13	5	4
180	A:A:E344	A:A:R347	11.63	Yes	No	0	5	4
181	A:A:L346	A:A:P361	6.57	No	No	13	4	5
182	A:A:C359	A:A:S349	5.16	No	No	7	5	7
183	A:A:D354	A:A:R356	10.72	No	Yes	0	3	2
184	A:A:G355	A:A:Y358	4.35	No	Yes	0	2	4
185	A:A:H357	A:A:R356	12.41	No	Yes	0	7	2
186	A:A:Y358	A:A:Y360	4.96	Yes	Yes	0	4	8
187	A:A:R385	A:A:Y358	14.4	Yes	Yes	0	5	4
188	A:A:R389	A:A:Y358	6.17	No	Yes	0	4	4
189	A:A:D378	A:A:Y360	14.94	No	Yes	0	7	8
190	A:A:D381	A:A:Y360	10.34	No	Yes	0	8	8
191	A:A:I382	A:A:Y360	7.25	No	Yes	0	6	8
192	A:A:H362	A:A:R374	5.64	No	Yes	16	9	4
193	A:A:D378	A:A:H362	10.08	No	No	0	7	9
194	A:A:N371	A:A:T364	5.85	No	Yes	16	9	9
195	A:A:R374	A:A:T364	3.88	Yes	Yes	16	4	9
196	A:A:N371	A:A:R374	8.44	No	Yes	16	9	4
197	A:A:F376	A:A:R373	5.34	Yes	Yes	15	8	5
198	A:A:N377	A:A:R373	7.23	No	Yes	15	4	5
199	A:A:F376	A:A:N377	3.62	Yes	No	15	8	4
200	A:A:N377	A:A:R380	10.85	No	No	0	4	7
201	A:A:Q384	A:A:R380	3.5	No	No	0	6	7
202	A:A:D381	A:A:R385	15.48	No	Yes	19	8	5
203	A:A:D381	R:R:K334	11.06	No	Yes	19	8	9
204	A:A:H387	A:A:I383	3.98	Yes	No	0	8	8
205	A:A:Q384	R:R:L255	3.99	No	Yes	0	6	8
206	A:A:Q384	R:R:K334	8.14	No	Yes	0	6	9
207	A:A:L394	A:A:R385	3.64	No	Yes	19	8	5
208	A:A:R385	R:R:K334	12.38	Yes	Yes	19	5	9
209	A:A:H387	A:A:M386	5.25	Yes	No	3	8	3
210	A:A:M386	A:A:R389	3.72	No	No	0	3	4
211	A:A:M386	A:A:Q390	5.44	No	No	3	3	4
212	A:A:H387	A:A:Q390	6.18	Yes	No	3	8	4
213	A:A:H387	R:R:L254	18	Yes	No	0	8	8
214	A:A:L388	A:A:L393	4.15	No	No	0	8	8
215	A:A:L388	A:A:L394	8.3	No	No	0	8	8
216	A:A:L388	R:R:L255	4.15	No	Yes	0	8	8
217	A:A:Q390	R:R:R176	3.5	No	Yes	3	4	9
218	A:A:Y391	R:R:R176	6.17	Yes	Yes	3	4	9
219	A:A:Y391	R:R:H180	4.36	Yes	Yes	3	4	9
220	A:A:Y391	R:R:E247	4.49	Yes	Yes	3	4	9
221	A:A:Y391	R:R:Y250	4.96	Yes	Yes	3	4	8
222	A:A:Y391	R:R:L251	9.38	Yes	No	0	4	9
223	A:A:Y391	R:R:Y402	5.96	Yes	Yes	3	4	8
224	A:A:E392	R:R:N407	13.15	No	No	0	6	6
225	A:A:L394	R:R:K334	5.64	No	Yes	19	8	9
226	B:B:E3	B:B:Q6	10.19	No	No	0	5	1
227	B:B:L4	B:B:R8	8.5	No	No	0	4	3
228	B:B:D5	B:B:R8	7.15	No	No	0	1	3
229	B:B:L7	B:B:Q6	9.32	No	No	0	8	1
230	B:B:Q13	B:B:Q9	7.68	No	No	0	1	3
231	B:B:E10	B:B:Q13	14.02	Yes	No	0	8	1
232	B:B:E10	B:B:L14	3.98	Yes	No	0	8	8
233	B:B:L14	B:B:Q17	6.65	No	Yes	0	8	4
234	B:B:L14	G:G:L19	5.54	No	No	0	8	9
235	B:B:K15	B:B:R19	8.66	No	No	0	6	4
236	B:B:N16	B:B:R19	4.82	No	No	0	1	4
237	B:B:I18	B:B:Q17	4.12	Yes	Yes	0	7	4
238	B:B:Q17	G:G:A23	4.55	Yes	No	0	4	8
239	B:B:I18	B:B:R22	3.76	Yes	No	0	7	6
240	B:B:I18	G:G:E22	6.83	Yes	Yes	0	7	9
241	B:B:I18	G:G:R27	5.01	Yes	Yes	0	7	8
242	B:B:D258	B:B:R22	11.91	Yes	No	0	7	6
243	B:B:Q259	B:B:R22	5.84	No	No	0	6	6
244	B:B:D27	G:G:K29	16.59	No	No	0	8	4
245	B:B:D27	G:G:S31	8.83	No	No	0	8	9
246	B:B:Q32	B:B:T29	7.09	No	No	0	1	3
247	B:B:L261	B:B:L30	4.15	No	No	0	5	5
248	B:B:L30	B:B:M262	9.9	No	Yes	0	5	4
249	B:B:L300	B:B:T34	4.42	No	No	0	6	5
250	B:B:N35	B:B:N36	9.54	No	No	0	1	1
251	B:B:I37	B:B:R283	3.76	No	Yes	0	2	9
252	B:B:I37	G:G:M38	4.37	No	No	0	2	4
253	B:B:K301	B:B:P39	5.02	No	No	0	5	1
254	B:B:G41	B:B:V40	3.68	No	Yes	0	1	3
255	B:B:R283	B:B:V40	6.54	Yes	Yes	8	9	3
256	B:B:D298	B:B:V40	7.3	Yes	Yes	8	9	3
257	B:B:V40	G:G:L51	4.47	Yes	Yes	8	3	6
258	B:B:Q44	B:B:R42	9.35	No	No	0	4	2
259	B:B:G306	B:B:R42	6	No	No	0	4	2
260	B:B:R42	R:R:L422	3.64	No	No	0	2	4
261	B:B:I43	B:B:L284	4.28	No	Yes	0	3	5
262	B:B:L308	B:B:M45	7.07	No	No	0	7	4
263	B:B:M45	G:G:L50	7.07	No	No	0	4	9
264	B:B:R46	B:B:R48	5.33	No	Yes	0	5	7
265	B:B:K337	B:B:T47	7.51	Yes	No	14	6	3
266	B:B:T47	B:B:W339	9.7	No	Yes	14	3	9
267	B:B:N340	B:B:R48	10.85	No	Yes	2	9	7
268	B:B:R48	G:G:N59	3.62	Yes	Yes	2	7	9
269	B:B:R48	G:G:R62	7.46	Yes	No	2	7	7
270	B:B:I338	B:B:R49	5.01	No	No	2	5	7
271	B:B:R49	G:G:F61	10.69	No	Yes	2	7	8
272	B:B:R52	B:B:T50	9.06	No	No	0	7	3
273	B:B:K337	B:B:T50	10.51	Yes	No	0	6	3
274	B:B:L51	B:B:W82	18.22	Yes	Yes	0	9	9
275	B:B:L336	B:B:L51	6.92	No	Yes	0	7	9
276	B:B:I338	B:B:L51	4.28	No	Yes	0	5	9
277	B:B:F335	B:B:R52	9.62	No	No	0	4	7
278	B:B:R52	R:R:R170	19.19	No	No	0	7	8
279	B:B:H54	B:B:I58	10.61	Yes	No	0	9	9
280	B:B:H54	B:B:S72	9.76	Yes	No	0	9	9
281	B:B:H54	B:B:S74	12.55	Yes	No	2	9	9
282	B:B:D76	B:B:H54	3.78	Yes	Yes	2	9	9
283	B:B:H54	B:B:I80	13.26	Yes	Yes	2	9	8
284	B:B:D76	B:B:L55	10.86	Yes	Yes	2	9	6
285	B:B:K57	B:B:Y59	5.97	Yes	Yes	1	9	8
286	B:B:K57	B:B:Q75	13.56	Yes	No	1	9	9
287	B:B:K57	B:B:W332	16.24	Yes	Yes	1	9	9
288	B:B:Q75	B:B:Y59	10.15	No	Yes	1	9	8
289	B:B:M101	B:B:Y59	7.18	Yes	Yes	1	9	8
290	B:B:W332	B:B:Y59	12.54	Yes	Yes	1	9	8
291	B:B:M61	B:B:W63	4.65	No	Yes	0	6	7
292	B:B:C317	B:B:M61	6.48	No	No	0	7	6
293	B:B:H62	B:B:Y105	4.36	No	Yes	0	6	6
294	B:B:H62	B:B:R150	16.93	No	No	0	6	6
295	B:B:L70	B:B:W63	5.69	No	Yes	0	5	7
296	B:B:S84	B:B:W63	4.94	No	Yes	0	5	7
297	B:B:T321	B:B:W63	10.92	No	Yes	0	7	7
298	B:B:A328	B:B:W63	3.89	No	Yes	0	5	7
299	B:B:G64	B:B:Y105	4.35	No	Yes	0	5	6
300	B:B:D322	B:B:T65	4.34	No	No	0	1	1
301	B:B:D66	B:B:R68	5.96	No	Yes	0	8	5
302	B:B:D66	B:B:L69	6.79	No	No	0	8	5
303	B:B:S67	B:B:T321	7.99	No	No	24	5	7
304	B:B:D323	B:B:S67	8.83	No	No	24	7	5
305	B:B:D83	B:B:R68	15.48	Yes	Yes	2	8	5
306	B:B:R68	B:B:Y85	25.72	Yes	No	2	5	4
307	B:B:R68	B:B:T86	3.88	Yes	Yes	2	5	6
308	B:B:D83	B:B:L69	4.07	Yes	No	0	8	5
309	B:B:L69	B:B:Y105	5.86	No	Yes	0	5	6
310	B:B:L70	B:B:W82	4.56	No	Yes	0	5	9
311	B:B:I81	B:B:V71	4.61	No	Yes	0	7	8
312	B:B:V71	B:B:Y105	3.79	Yes	Yes	6	8	6
313	B:B:V112	B:B:V71	4.81	Yes	Yes	6	8	8
314	B:B:S72	B:B:W82	7.41	No	Yes	0	9	9
315	B:B:L336	B:B:S72	7.51	No	No	0	7	9
316	B:B:A73	B:B:C103	3.61	No	No	0	9	8
317	B:B:D76	B:B:S74	8.83	Yes	No	2	9	9
318	B:B:Q75	B:B:W99	6.57	No	Yes	1	9	9
319	B:B:D76	B:B:K78	8.3	Yes	Yes	0	9	8
320	B:B:G77	B:B:L95	5.13	No	Yes	0	8	8
321	B:B:K78	B:B:P94	6.69	Yes	No	0	8	5
322	B:B:I93	B:B:L79	8.56	No	No	0	7	7
323	B:B:L79	B:B:L95	6.92	No	Yes	6	7	8
324	B:B:C114	B:B:L79	6.35	Yes	No	6	8	7
325	B:B:I80	B:B:W82	15.27	Yes	Yes	2	8	9
326	B:B:I80	B:B:K89	5.82	Yes	Yes	2	8	9
327	B:B:H91	B:B:I81	9.28	No	No	0	5	7
328	B:B:K89	B:B:W82	10.44	Yes	Yes	2	9	9
329	B:B:D83	B:B:T86	8.67	Yes	Yes	2	8	6
330	B:B:S84	G:G:F61	5.28	No	Yes	0	5	8
331	B:B:Y85	G:G:P60	12.52	No	No	2	4	9
332	B:B:Y85	G:G:F61	7.22	No	Yes	2	4	8
333	B:B:N88	B:B:T86	8.77	No	Yes	2	7	6
334	B:B:H91	B:B:V90	8.3	No	No	0	5	5
335	B:B:H91	B:B:V133	4.15	No	No	0	5	4
336	B:B:I93	B:B:Y124	7.25	No	Yes	0	7	6
337	B:B:I93	B:B:V133	6.14	No	No	0	7	4
338	B:B:L95	B:B:V100	4.47	Yes	No	6	8	9
339	B:B:C114	B:B:L95	4.76	Yes	Yes	6	8	8
340	B:B:L95	B:B:Y124	7.03	Yes	Yes	6	8	6
341	B:B:D118	B:B:S97	11.78	No	No	0	9	8
342	B:B:S98	B:B:W99	3.71	No	Yes	0	8	9
343	B:B:L117	B:B:W99	4.56	Yes	Yes	1	9	9
344	B:B:C114	B:B:V100	5.12	Yes	No	6	8	9
345	B:B:G116	B:B:M101	5.24	No	Yes	0	9	9
346	B:B:M101	B:B:Y145	8.38	Yes	Yes	1	9	8
347	B:B:C149	B:B:T102	5.07	No	No	0	8	8
348	B:B:G109	B:B:Y105	5.79	No	Yes	0	5	6
349	B:B:V112	B:B:Y105	3.79	Yes	Yes	6	8	6
350	B:B:L126	B:B:Y105	3.52	No	Yes	6	5	6
351	B:B:A106	B:B:F151	4.16	No	Yes	0	6	9
352	B:B:N110	B:B:S108	7.45	Yes	No	12	4	6
353	B:B:D154	B:B:S108	8.83	No	No	12	6	6
354	B:B:N110	B:B:Y111	4.65	Yes	Yes	12	4	4
355	B:B:K127	B:B:N110	6.99	No	Yes	0	4	4
356	B:B:D154	B:B:N110	6.73	No	Yes	12	6	4
357	B:B:I123	B:B:Y111	3.63	Yes	Yes	12	6	4
358	B:B:N125	B:B:Y111	10.47	No	Yes	0	4	4
359	B:B:S136	B:B:Y111	5.09	No	Yes	0	4	4
360	B:B:D154	B:B:Y111	9.2	No	Yes	12	6	4
361	B:B:V112	B:B:Y124	3.79	Yes	Yes	6	8	6
362	B:B:L126	B:B:V112	5.96	No	Yes	6	5	8
363	B:B:C114	B:B:Y124	4.03	Yes	Yes	6	8	6
364	B:B:L117	B:B:Y145	3.52	Yes	Yes	1	9	8
365	B:B:D118	B:B:I120	7	No	No	0	9	6
366	B:B:G144	B:B:N119	5.09	No	Yes	1	8	9
367	B:B:C121	B:B:L139	6.35	No	No	0	8	9
368	B:B:C121	B:B:C149	3.64	No	No	0	8	8
369	B:B:S122	B:B:Y124	5.09	No	Yes	0	8	6
370	B:B:I123	B:B:L139	4.28	Yes	No	0	6	9
371	B:B:F151	B:B:I123	5.02	Yes	Yes	0	9	6
372	B:B:I123	B:B:I171	8.83	Yes	No	12	6	6
373	B:B:V135	B:B:Y124	6.31	No	Yes	0	4	6
374	B:B:N125	B:B:T128	4.39	No	No	0	4	3
375	B:B:K127	B:B:L126	4.23	No	No	0	4	5
376	B:B:E130	B:B:T128	11.29	No	No	0	3	3
377	B:B:E130	B:B:R134	13.96	No	No	0	3	3
378	B:B:N132	B:B:R134	6.03	No	No	0	3	3
379	B:B:E138	B:B:V135	7.13	No	No	0	6	4
380	B:B:G174	B:B:R137	6	No	No	0	4	5
381	B:B:L139	B:B:W169	15.94	No	Yes	0	9	8
382	B:B:G141	B:B:W169	4.22	No	Yes	0	5	8
383	B:B:H142	B:B:L146	3.86	Yes	No	9	9	7
384	B:B:H142	B:B:T159	6.85	Yes	No	9	9	9
385	B:B:H142	B:B:S161	16.74	Yes	No	9	9	9
386	B:B:D163	B:B:H142	6.3	Yes	Yes	9	9	9
387	B:B:H142	B:B:W169	7.41	Yes	Yes	9	9	8
388	B:B:D163	B:B:T143	5.78	Yes	No	0	9	5
389	B:B:G162	B:B:Y145	5.79	No	Yes	0	9	8
390	B:B:D186	B:B:Y145	10.34	No	Yes	0	9	8
391	B:B:M188	B:B:Y145	4.79	No	Yes	1	8	8
392	B:B:L146	B:B:T159	8.84	No	No	9	7	9
393	B:B:S147	B:B:S160	4.89	No	No	0	9	6
394	B:B:C148	B:B:R150	5.57	No	No	0	6	6
395	B:B:C148	B:B:L190	4.76	No	Yes	0	6	5
396	B:B:F151	B:B:I157	3.77	Yes	No	0	9	7
397	B:B:L152	B:B:Q156	9.32	No	No	0	3	5
398	B:B:L152	B:B:L192	4.15	No	No	0	3	5
399	B:B:L152	B:B:T196	4.42	No	No	0	3	1
400	B:B:D153	B:B:N155	4.04	No	No	0	5	3
401	B:B:D153	B:B:Q156	5.22	No	No	0	5	5
402	B:B:D170	B:B:N155	9.42	Yes	No	20	9	3
403	B:B:E172	B:B:N155	6.57	No	No	20	6	3
404	B:B:I157	B:B:W169	3.52	No	Yes	0	7	8
405	B:B:I157	B:B:I171	4.42	No	No	0	7	6
406	B:B:L190	B:B:V158	4.47	Yes	No	10	5	5
407	B:B:F199	B:B:V158	5.24	Yes	No	10	9	5
408	B:B:T159	B:B:W169	10.92	No	Yes	9	9	8
409	B:B:S160	B:B:V187	6.46	No	No	0	6	9
410	B:B:L190	B:B:S160	4.5	Yes	No	0	5	6
411	B:B:G162	B:B:S161	3.71	No	No	0	9	9
412	B:B:D163	B:B:S161	7.36	Yes	No	9	9	9
413	B:B:D163	B:B:T165	11.56	Yes	No	0	9	7
414	B:B:C166	B:B:F180	4.19	No	Yes	10	8	7
415	B:B:C166	B:B:V187	5.12	No	No	0	8	9
416	B:B:C166	B:B:F199	4.19	No	Yes	10	8	9
417	B:B:A167	B:B:W169	5.19	No	Yes	9	4	8
418	B:B:A167	B:B:Q176	4.55	No	No	9	4	4
419	B:B:L168	B:B:T178	5.9	No	No	0	6	4
420	B:B:Q176	B:B:W169	14.24	No	Yes	9	4	8
421	B:B:D170	B:B:E172	7.8	Yes	No	20	9	6
422	B:B:D170	B:B:T173	7.23	Yes	No	20	9	5
423	B:B:D170	B:B:T177	4.34	Yes	No	0	9	4
424	B:B:E172	B:B:T173	8.47	No	No	20	6	5
425	B:B:Q175	B:B:T173	5.67	No	No	0	4	5
426	B:B:F180	B:B:T178	6.49	Yes	No	0	7	4
427	B:B:F180	B:B:F199	12.86	Yes	Yes	10	7	9
428	B:B:F180	B:B:W211	13.03	Yes	Yes	10	7	8
429	B:B:F180	B:B:G216	4.52	Yes	No	0	7	4
430	B:B:H183	B:B:V187	9.69	Yes	No	0	9	9
431	B:B:H183	B:B:S201	5.58	Yes	No	0	9	9
432	B:B:A203	B:B:H183	8.78	No	Yes	0	8	9
433	B:B:D205	B:B:H183	5.04	No	Yes	0	9	9
434	B:B:H183	B:B:K209	18.34	Yes	Yes	0	9	6
435	B:B:D205	B:B:T184	5.78	No	No	0	9	3
436	B:B:C204	B:B:D186	7.78	Yes	No	0	7	9
437	B:B:F199	B:B:L190	7.31	Yes	Yes	10	9	5
438	B:B:F234	B:B:S191	6.61	Yes	No	0	5	8
439	B:B:F199	B:B:L192	3.65	Yes	No	0	9	5
440	B:B:A193	B:B:D195	4.63	No	No	0	4	5
441	B:B:A193	B:B:F234	4.16	No	Yes	0	4	5
442	B:B:G238	B:B:P194	4.06	No	No	0	7	4
443	B:B:D195	B:B:R197	8.34	No	No	0	5	5
444	B:B:R197	B:B:R214	9.6	No	No	0	5	9
445	B:B:L198	B:B:L210	6.92	No	Yes	4	3	5
446	B:B:L198	B:B:R219	3.64	No	No	4	3	5
447	B:B:F199	B:B:W211	14.03	Yes	Yes	10	9	8
448	B:B:I232	B:B:V200	7.68	Yes	No	4	8	6
449	B:B:F234	B:B:V200	10.49	Yes	No	0	5	6
450	B:B:F241	B:B:V200	15.73	Yes	No	4	6	6
451	B:B:S201	B:B:W211	7.41	No	Yes	0	9	8
452	B:B:G202	B:B:I229	5.29	No	No	0	6	7
453	B:B:C204	B:B:D228	10.89	Yes	Yes	1	7	9
454	B:B:D205	B:B:S207	5.89	No	No	0	9	5
455	B:B:K209	B:B:S207	4.59	Yes	No	0	6	5
456	B:B:K209	B:B:W211	8.12	Yes	Yes	10	6	8
457	B:B:C218	B:B:K209	4.85	No	Yes	10	5	6
458	B:B:K209	B:B:T221	12.01	Yes	No	0	6	7
459	B:B:L210	B:B:R219	6.07	Yes	No	4	5	5
460	B:B:L210	B:B:Q220	7.99	Yes	Yes	4	5	7
461	B:B:L210	B:B:L255	4.15	Yes	No	0	5	6
462	B:B:C218	B:B:W211	5.22	No	Yes	10	5	8
463	B:B:D212	B:B:E215	12.99	No	No	0	9	3
464	B:B:E215	B:B:R214	4.65	No	No	0	3	9
465	B:B:E215	B:B:M217	8.12	No	No	0	3	3
466	B:B:C218	G:G:Q18	9.16	No	No	0	5	9
467	B:B:Q220	B:B:R219	7.01	Yes	No	4	7	5
468	B:B:F222	B:B:Q220	7.03	Yes	Yes	4	8	7
469	B:B:D258	B:B:Q220	10.44	Yes	Yes	4	7	7
470	B:B:Q220	G:G:I25	4.12	Yes	No	0	7	2
471	B:B:T221	G:G:E22	8.47	No	Yes	0	7	9
472	B:B:F222	B:B:F241	11.79	Yes	Yes	4	8	6
473	B:B:F222	B:B:F253	9.65	Yes	Yes	4	8	6
474	B:B:D258	B:B:F222	3.58	Yes	Yes	4	7	8
475	B:B:H225	B:B:I229	7.95	Yes	No	4	9	7
476	B:B:H225	B:B:T243	12.32	Yes	Yes	4	9	8
477	B:B:H225	B:B:S245	13.95	Yes	No	4	9	9
478	B:B:D247	B:B:H225	5.04	Yes	Yes	4	9	9
479	B:B:H225	B:B:R251	20.31	Yes	Yes	4	9	8
480	B:B:F253	B:B:H225	4.53	Yes	Yes	4	6	9
481	B:B:D247	B:B:E226	10.39	Yes	No	0	9	3
482	B:B:D228	B:B:S227	5.89	Yes	No	0	9	6
483	B:B:D246	B:B:S227	4.42	Yes	No	0	9	6
484	B:B:I229	B:B:T243	4.56	No	Yes	4	7	8
485	B:B:D246	B:B:N230	9.42	Yes	No	1	9	9
486	B:B:F241	B:B:I232	5.02	Yes	Yes	4	6	8
487	B:B:I232	B:B:T243	4.56	Yes	Yes	4	8	8
488	B:B:F234	B:B:L255	4.87	Yes	No	0	5	6
489	B:B:F235	B:B:P236	8.67	Yes	Yes	17	6	7
490	B:B:F235	B:B:F278	7.5	Yes	Yes	17	6	7
491	B:B:F235	B:B:G282	4.52	Yes	No	17	6	9
492	B:B:F235	G:G:L37	4.87	Yes	No	0	6	7
493	B:B:F235	G:G:Y40	6.19	Yes	Yes	17	6	6
494	B:B:F278	B:B:P236	5.78	Yes	Yes	17	7	7
495	B:B:G282	B:B:P236	4.06	No	Yes	17	9	7
496	B:B:P236	G:G:Y40	5.56	Yes	Yes	17	7	6
497	B:B:N237	B:B:N239	8.17	No	No	0	5	2
498	B:B:N237	G:G:Y40	12.79	No	Yes	0	5	6
499	B:B:N239	B:B:R256	15.67	No	No	0	2	9
500	B:B:F241	B:B:F253	11.79	Yes	Yes	4	6	6
501	B:B:G244	B:B:T243	3.64	No	Yes	0	5	8
502	B:B:F253	B:B:T243	9.08	Yes	Yes	4	6	8
503	B:B:G244	B:B:I273	7.05	No	No	0	5	6
504	B:B:D247	B:B:S245	8.83	Yes	No	4	9	9
505	B:B:D247	B:B:T249	13.01	Yes	Yes	4	9	6
506	B:B:D247	B:B:R251	4.76	Yes	Yes	4	9	8
507	B:B:R251	B:B:T249	10.35	Yes	Yes	4	8	6
508	B:B:T249	B:B:T263	4.71	Yes	No	4	6	1
509	B:B:S265	B:B:T249	4.8	No	Yes	0	2	6
510	B:B:C250	B:B:Y264	4.03	No	Yes	0	8	5
511	B:B:C250	B:B:I273	6.55	No	No	0	8	6
512	B:B:F253	B:B:R251	4.28	Yes	Yes	4	6	8
513	B:B:E260	B:B:R251	11.63	No	Yes	4	6	8
514	B:B:R251	B:B:T263	11.64	Yes	No	4	8	1
515	B:B:L252	B:B:L261	4.15	No	No	0	7	5
516	B:B:L252	B:B:Y264	5.86	No	Yes	0	7	5
517	B:B:E260	B:B:F253	7	No	Yes	4	6	6
518	B:B:A257	B:B:D254	4.63	No	No	0	7	9
519	B:B:D254	B:B:L261	12.21	No	No	0	9	5
520	B:B:D254	G:G:A33	4.63	No	No	0	9	7
521	B:B:R256	G:G:I28	7.52	No	No	0	9	4
522	B:B:R256	G:G:D36	7.15	No	No	0	9	5
523	B:B:A257	B:B:Q259	4.55	No	No	0	7	6
524	B:B:D258	G:G:R27	9.53	Yes	Yes	0	7	8
525	B:B:Q259	G:G:V30	5.73	No	No	0	6	8
526	B:B:M262	B:B:Y264	13.17	Yes	Yes	0	4	5
527	B:B:A302	B:B:M262	4.83	No	Yes	0	2	4
528	B:B:L285	B:B:Y264	4.69	Yes	Yes	0	6	5
529	B:B:W297	B:B:Y264	11.58	Yes	Yes	0	8	5
530	B:B:H266	B:B:N268	8.93	No	No	0	4	4
531	B:B:H266	B:B:I269	3.98	No	Yes	11	4	4
532	B:B:H266	B:B:R304	9.03	No	Yes	11	4	5
533	B:B:I269	B:B:Y289	6.04	Yes	Yes	11	4	7
534	B:B:I269	B:B:N295	4.25	Yes	Yes	11	4	6
535	B:B:I269	B:B:R304	3.76	Yes	Yes	11	4	5
536	B:B:C271	B:B:Y289	4.03	No	Yes	0	5	7
537	B:B:C271	B:B:D291	6.22	No	No	0	5	8
538	B:B:I273	B:B:Y289	10.88	No	Yes	0	6	7
539	B:B:D290	B:B:T274	7.23	Yes	No	1	6	8
540	B:B:R314	B:B:T274	5.17	Yes	No	1	8	8
541	B:B:L318	B:B:S275	6.01	No	No	0	6	8
542	B:B:F278	B:B:G282	4.52	Yes	No	17	7	9
543	B:B:F278	B:B:L285	6.09	Yes	Yes	0	7	6
544	B:B:L284	B:B:S279	4.5	Yes	No	0	5	9
545	B:B:S279	G:G:D48	8.83	No	Yes	0	9	9
546	B:B:G324	B:B:K280	5.23	No	No	0	9	1
547	B:B:S281	G:G:D48	10.31	No	Yes	0	9	9
548	B:B:D298	B:B:R283	15.48	Yes	Yes	8	9	9
549	B:B:L300	B:B:R283	10.93	No	Yes	8	6	9
550	B:B:R283	G:G:C41	5.57	Yes	No	8	9	7
551	B:B:R283	G:G:L51	4.86	Yes	Yes	8	9	6
552	B:B:L284	B:B:V296	5.96	Yes	No	0	5	5
553	B:B:L284	G:G:L51	4.15	Yes	Yes	0	5	6
554	B:B:L286	B:B:V296	4.47	No	No	0	7	5
555	B:B:L286	B:B:V327	4.47	No	No	0	7	6
556	B:B:A287	B:B:Y289	5.34	No	Yes	0	6	7
557	B:B:C294	B:B:G288	3.92	No	No	0	5	7
558	B:B:N295	B:B:Y289	11.63	Yes	Yes	11	6	7
559	B:B:W297	B:B:Y289	5.79	Yes	Yes	11	8	7
560	B:B:D290	B:B:R314	11.91	Yes	Yes	1	6	8
561	B:B:D291	B:B:N293	12.12	No	Yes	0	8	5
562	B:B:F292	B:B:N313	3.62	No	No	0	4	7
563	B:B:N293	B:B:N295	5.45	Yes	Yes	11	5	6
564	B:B:N293	B:B:V307	4.43	Yes	No	11	5	3
565	B:B:C294	B:B:V315	5.12	No	No	0	5	7
566	B:B:N295	B:B:W297	4.52	Yes	Yes	11	6	8
567	B:B:N295	B:B:R304	15.67	Yes	Yes	11	6	5
568	B:B:N295	B:B:V307	4.43	Yes	No	11	6	3
569	B:B:R304	B:B:W297	4	Yes	Yes	11	5	8
570	B:B:D298	B:B:K301	11.06	Yes	No	8	9	5
571	B:B:D298	B:B:D303	3.99	Yes	No	8	9	2
572	B:B:L300	G:G:C41	6.35	No	No	8	6	7
573	B:B:D303	B:B:K301	5.53	No	No	8	2	5
574	B:B:L308	B:B:W339	20.5	No	Yes	0	7	9
575	B:B:G310	R:R:R419	4.5	No	No	0	5	7
576	B:B:H311	B:B:V315	4.15	Yes	No	0	9	7
577	B:B:H311	B:B:T329	6.85	Yes	No	0	9	8
578	B:B:H311	B:B:S331	16.74	Yes	No	14	9	9
579	B:B:D333	B:B:H311	5.04	Yes	Yes	14	9	9
580	B:B:H311	B:B:K337	14.41	Yes	Yes	14	9	6
581	B:B:D312	B:B:D333	6.65	No	Yes	0	5	9
582	B:B:D312	R:R:H171	18.91	No	No	0	5	7
583	B:B:D312	R:R:K415	8.3	No	No	0	5	7
584	B:B:N313	B:B:W332	5.65	No	Yes	0	7	9
585	B:B:D333	B:B:N313	4.04	Yes	No	0	9	7
586	B:B:R314	B:B:W332	23.99	Yes	Yes	1	8	9
587	B:B:S316	B:B:W332	4.94	No	Yes	0	9	9
588	B:B:L318	B:B:T329	4.42	No	No	0	6	8
589	B:B:V320	B:B:V327	6.41	No	No	0	7	6
590	B:B:D323	B:B:T321	7.23	No	No	24	7	7
591	B:B:D323	B:B:M325	8.32	No	No	0	7	5
592	B:B:M325	G:G:P49	5.03	No	No	0	5	7
593	B:B:A326	G:G:F61	4.16	No	Yes	0	7	8
594	B:B:T329	B:B:W339	9.7	No	Yes	0	8	9
595	B:B:G330	B:B:L336	5.13	No	No	0	5	7
596	B:B:D333	B:B:S331	8.83	Yes	No	14	9	9
597	B:B:D333	B:B:F335	8.36	Yes	No	0	9	4
598	B:B:F335	B:B:S334	3.96	No	No	0	4	4
599	B:B:K337	B:B:W339	8.12	Yes	Yes	14	6	9
600	B:B:I338	G:G:F61	6.28	No	Yes	2	5	8
601	B:B:N340	G:G:N59	13.62	No	Yes	2	9	9
602	B:B:N340	G:G:F61	4.83	No	Yes	2	9	8
603	G:G:I9	G:G:T6	6.08	No	No	0	2	3
604	G:G:I9	G:G:R13	6.26	No	No	0	2	6
605	G:G:E17	G:G:K14	4.05	No	No	0	6	4
606	G:G:K20	G:G:V16	4.55	No	No	0	6	7
607	G:G:E22	G:G:Q18	5.1	Yes	No	0	9	9
608	G:G:E22	G:G:L19	3.98	Yes	No	0	9	9
609	G:G:M21	G:G:N24	4.21	No	No	0	1	1
610	G:G:I25	G:G:R27	7.52	No	Yes	0	2	8
611	G:G:H44	G:G:Y40	25.04	No	Yes	0	6	6
612	G:G:E47	G:G:H44	6.15	No	No	0	3	6
613	G:G:D48	G:G:L51	9.5	Yes	Yes	0	9	6
614	G:G:P55	G:G:V54	3.53	No	No	2	5	6
615	G:G:E58	G:G:V54	4.28	No	No	2	5	6
616	G:G:N59	G:G:V54	7.39	Yes	No	2	9	6
617	G:G:E58	G:G:P55	14.15	No	No	2	5	5
618	G:G:A56	G:G:R62	5.53	No	No	0	4	7
619	G:G:E58	G:G:S57	7.19	No	No	0	5	6
620	G:G:N59	G:G:P60	6.52	Yes	No	2	9	9
621	G:G:N59	G:G:R62	8.44	Yes	No	2	9	7
622	G:G:F61	G:G:P60	7.22	Yes	No	2	8	9
623	R:R:E139	R:R:P137	4.72	No	No	0	2	3
624	R:R:E138	R:R:L141	7.95	No	No	0	2	5
625	R:R:E138	R:R:L142	5.3	No	No	0	2	3
626	R:R:E139	R:R:Q140	5.1	No	No	0	2	4
627	R:R:F143	R:R:I146	7.54	No	No	0	4	4
628	R:R:F143	R:R:I147	3.77	No	No	0	4	6
629	R:R:L144	R:R:L384	4.15	No	No	0	6	5
630	R:R:F385	R:R:L144	3.65	No	No	0	6	6
631	R:R:L144	R:R:L388	8.3	No	No	0	6	7
632	R:R:T149	R:R:Y145	8.74	No	Yes	5	7	5
633	R:R:D198	R:R:Y145	10.34	No	Yes	5	7	5
634	R:R:L201	R:R:Y145	7.03	Yes	Yes	5	7	5
635	R:R:K202	R:R:Y145	4.78	Yes	Yes	5	4	5
636	R:R:Y145	W:W:?1	10.1	Yes	Yes	5	5	0
637	R:R:Y148	R:R:Y152	15.89	Yes	Yes	5	7	7
638	R:R:V194	R:R:Y148	8.83	No	Yes	5	7	7
639	R:R:S392	R:R:Y148	7.63	No	Yes	5	9	7
640	R:R:Y148	W:W:?1	4.42	Yes	Yes	5	7	0
641	R:R:D198	R:R:T149	7.23	No	No	5	7	7
642	R:R:F393	R:R:G151	9.03	No	No	0	7	8
643	R:R:R190	R:R:Y152	4.12	Yes	Yes	0	8	7
644	R:R:A191	R:R:Y152	5.34	No	Yes	0	7	7
645	R:R:V194	R:R:Y152	16.4	No	Yes	5	7	7
646	R:R:S392	R:R:Y152	10.17	No	Yes	5	9	7
647	R:R:G395	R:R:S155	3.71	No	No	0	9	9
648	R:R:F156	R:R:I188	7.54	Yes	No	0	7	7
649	R:R:A191	R:R:F156	4.16	No	Yes	0	7	7
650	R:R:F156	R:R:L192	3.65	Yes	No	0	7	3
651	R:R:F156	R:R:F195	10.72	Yes	No	0	7	7
652	R:R:F184	R:R:L159	4.87	No	Yes	0	8	9
653	R:R:F187	R:R:L159	6.09	Yes	Yes	3	8	9
654	R:R:I188	R:R:L159	4.28	No	Yes	0	7	9
655	R:R:G395	R:R:L159	5.13	No	Yes	3	9	9
656	R:R:F404	R:R:I161	3.77	Yes	No	0	8	4
657	R:R:A162	R:R:C403	3.61	No	No	0	9	9
658	R:R:F184	R:R:S163	3.96	No	No	0	8	6
659	R:R:F169	R:R:I165	3.77	Yes	No	18	7	8
660	R:R:C403	R:R:I165	4.91	No	No	0	9	8
661	R:R:F413	R:R:I165	7.54	No	No	18	5	8
662	R:R:L166	R:R:N177	6.87	No	Yes	0	8	9
663	R:R:L166	R:R:L181	4.15	No	No	0	8	6
664	R:R:L167	R:R:L181	4.15	No	No	0	3	6
665	R:R:F169	R:R:L172	7.31	Yes	Yes	18	7	9
666	R:R:E412	R:R:F169	8.16	Yes	Yes	18	8	7
667	R:R:F169	R:R:F413	9.65	Yes	No	18	7	5
668	R:R:E412	R:R:H171	12.31	Yes	No	0	8	7
669	R:R:E408	R:R:L172	3.98	No	Yes	0	9	9
670	R:R:L172	R:R:V409	5.96	Yes	No	0	9	9
671	R:R:E412	R:R:L172	11.93	Yes	Yes	18	8	9
672	R:R:H173	R:R:Y178	11.98	No	No	0	7	6
673	R:R:C174	R:R:N177	6.3	No	Yes	0	8	9
674	R:R:T175	R:R:Y250	4.99	No	Yes	0	7	8
675	R:R:F266	R:R:T175	3.89	Yes	No	0	6	7
676	R:R:N177	R:R:R176	6.03	Yes	Yes	3	9	9
677	R:R:H180	R:R:R176	5.64	Yes	Yes	3	9	9
678	R:R:R176	R:R:Y250	4.12	Yes	Yes	3	9	8
679	R:R:H180	R:R:N177	3.83	Yes	Yes	3	9	9
680	R:R:F266	R:R:Y178	8.25	Yes	No	0	6	6
681	R:R:I179	R:R:W243	4.7	No	Yes	0	8	9
682	R:R:E247	R:R:I179	10.93	Yes	No	0	9	8
683	R:R:E247	R:R:H180	11.08	Yes	Yes	3	9	9
684	R:R:H180	R:R:Y402	7.62	Yes	Yes	3	9	8
685	R:R:N182	R:R:W243	12.43	No	Yes	3	9	9
686	R:R:N182	R:R:W274	5.65	No	Yes	3	9	9
687	R:R:F187	R:R:L183	4.87	Yes	No	3	8	9
688	R:R:L183	R:R:L244	4.15	No	No	3	9	9
689	R:R:E247	R:R:L183	5.3	Yes	No	3	9	9
690	R:R:F184	R:R:V398	3.93	No	No	0	8	9
691	R:R:N240	R:R:S186	5.96	Yes	No	3	9	9
692	R:R:S186	R:R:W243	6.18	No	Yes	3	9	9
693	R:R:S186	R:R:W274	6.18	No	Yes	3	9	9
694	R:R:F187	R:R:N240	18.12	Yes	Yes	3	8	9
695	R:R:F187	R:R:L244	4.87	Yes	No	3	8	9
696	R:R:F187	R:R:Q394	11.71	Yes	No	0	8	9
697	R:R:F187	R:R:G395	7.53	Yes	No	3	8	9
698	R:R:F187	R:R:V398	7.87	Yes	No	0	8	9
699	R:R:C236	R:R:L189	6.35	No	No	0	5	7
700	R:R:R190	R:R:V237	10.46	Yes	No	0	8	6
701	R:R:N240	R:R:R190	9.64	Yes	Yes	0	9	8
702	R:R:R190	R:R:Y241	12.35	Yes	Yes	0	8	8
703	R:R:M233	R:R:S193	6.13	No	No	0	6	6
704	R:R:V194	W:W:?1	4.01	No	Yes	5	7	0
705	R:R:K197	R:R:M233	7.2	No	No	0	6	6
706	R:R:K197	W:W:?1	25.07	No	Yes	0	6	0
707	R:R:D198	R:R:K202	8.3	No	Yes	5	7	4
708	R:R:A200	W:W:?1	10.18	No	Yes	0	4	0
709	R:R:K202	R:R:L201	7.05	Yes	Yes	5	4	7
710	R:R:L201	R:R:M204	4.24	Yes	No	5	7	3
711	R:R:L201	R:R:Y205	14.07	Yes	No	5	7	3
712	R:R:L201	W:W:?1	10.44	Yes	Yes	5	7	0
713	R:R:K202	R:R:Y205	4.78	Yes	No	5	4	3
714	R:R:M204	R:R:W203	4.65	No	Yes	5	3	3
715	R:R:T207	R:R:W203	12.13	No	Yes	0	3	3
716	R:R:A208	R:R:W203	3.89	No	Yes	0	4	3
717	R:R:W203	W:W:?1	13.5	Yes	Yes	5	3	0
718	R:R:M204	W:W:?1	12.95	No	Yes	5	3	0
719	R:R:S206	R:R:T207	4.8	No	No	0	4	3
720	R:R:Q211	R:R:Q213	10.24	No	No	0	4	4
721	R:R:H212	R:R:W214	5.29	No	No	0	3	1
722	R:R:L217	W:W:?1	6.71	No	Yes	0	4	0
723	R:R:S225	R:R:Y220	7.63	No	Yes	0	3	3
724	R:R:C226	R:R:Y220	9.41	No	Yes	5	9	3
725	R:R:V229	R:R:Y220	6.31	No	Yes	0	7	3
726	R:R:W297	R:R:Y220	4.82	Yes	Yes	5	8	3
727	R:R:Y220	W:W:?1	9.47	Yes	Yes	5	3	0
728	R:R:Q221	R:R:W297	15.33	No	Yes	0	4	8
729	R:R:D222	R:R:R227	5.96	No	No	0	6	8
730	R:R:S223	R:R:S225	6.52	No	No	0	4	3
731	R:R:C226	R:R:C296	7.28	No	No	5	9	9
732	R:R:C226	R:R:W297	5.22	No	Yes	5	9	8
733	R:R:C296	R:R:R227	5.57	No	No	0	9	8
734	R:R:F230	R:R:Q234	14.05	No	No	0	5	7
735	R:R:F230	R:R:W284	5.01	No	Yes	0	5	8
736	R:R:F230	W:W:?1	7.22	No	Yes	0	5	0
737	R:R:A239	R:R:Y235	5.34	No	No	0	8	9
738	R:R:W274	R:R:Y235	7.72	Yes	No	0	9	9
739	R:R:L278	R:R:Y235	5.86	No	No	0	3	9
740	R:R:A239	R:R:P277	3.74	No	No	0	8	9
741	R:R:L244	R:R:N240	5.49	No	Yes	3	9	9
742	R:R:I313	R:R:Y241	8.46	No	Yes	0	7	8
743	R:R:I317	R:R:Y241	4.84	No	Yes	0	7	8
744	R:R:E364	R:R:Y241	10.1	No	Yes	0	8	8
745	R:R:L245	R:R:Y242	4.69	No	Yes	0	8	6
746	R:R:V276	R:R:Y242	3.79	No	Yes	25	3	6
747	R:R:P277	R:R:Y242	8.34	No	Yes	25	9	6
748	R:R:F280	R:R:Y242	9.28	No	Yes	0	5	6
749	R:R:A316	R:R:Y242	6.67	No	Yes	0	7	6
750	R:R:V246	R:R:W243	6.13	No	Yes	0	8	9
751	R:R:V270	R:R:W243	4.9	No	Yes	0	5	9
752	R:R:G273	R:R:W243	8.44	No	Yes	0	9	9
753	R:R:W243	R:R:W274	25.3	Yes	Yes	3	9	9
754	R:R:L245	R:R:N320	9.61	No	No	0	8	9
755	R:R:V246	R:R:Y269	5.05	No	Yes	0	8	7
756	R:R:E247	R:R:L359	7.95	Yes	No	0	9	9
757	R:R:G248	R:R:I323	3.53	No	No	0	8	8
758	R:R:V249	R:R:Y269	5.05	No	Yes	0	6	7
759	R:R:L254	R:R:Y250	12.89	No	Yes	0	8	8
760	R:R:Y250	R:R:Y269	4.96	Yes	Yes	0	8	7
761	R:R:L251	R:R:L255	4.15	No	Yes	0	9	8
762	R:R:L251	R:R:V327	4.47	No	No	0	9	9
763	R:R:A256	R:R:Y252	8.01	No	No	0	6	8
764	R:R:F257	R:R:Y252	6.19	No	No	0	5	8
765	R:R:R326	R:R:Y252	9.26	No	No	0	8	8
766	R:R:F257	R:R:T253	5.19	No	No	0	5	7
767	R:R:T253	R:R:Y269	3.75	No	Yes	0	7	7
768	R:R:I330	R:R:L255	4.28	No	Yes	0	9	8
769	R:R:E262	R:R:F260	3.5	No	No	0	6	7
770	R:R:F260	R:R:I265	3.77	No	No	0	7	5
771	R:R:I265	R:R:W264	3.52	No	No	0	5	5
772	R:R:I265	R:R:Y269	4.84	No	Yes	0	5	7
773	R:R:F266	R:R:R267	8.55	Yes	No	0	6	4
774	R:R:F266	R:R:V270	5.24	Yes	No	0	6	5
775	R:R:I272	R:R:L268	5.71	No	No	0	6	2
776	R:R:I272	R:R:V276	6.14	No	No	0	6	3
777	R:R:P277	R:R:V276	3.53	No	No	25	9	3
778	R:R:F280	R:R:P312	15.89	No	No	0	5	8
779	R:R:W284	R:R:W306	8.43	Yes	Yes	0	8	6
780	R:R:I308	R:R:W284	8.22	No	Yes	0	8	8
781	R:R:I309	R:R:W284	15.27	No	Yes	0	7	8
782	R:R:L290	R:R:Y291	4.69	No	No	0	3	3
783	R:R:E292	R:R:N300	17.09	No	No	0	6	6
784	R:R:E292	R:R:Y305	11.22	No	No	0	6	4
785	R:R:E294	R:R:G295	4.91	No	No	0	4	4
786	R:R:E294	R:R:T298	4.23	No	No	0	4	5
787	R:R:C296	R:R:W297	6.53	No	Yes	5	9	8
788	R:R:W297	W:W:?1	26.38	Yes	Yes	5	8	0
789	R:R:M303	R:R:R299	3.72	No	No	21	5	4
790	R:R:R299	R:R:W306	10	No	Yes	21	4	6
791	R:R:R299	R:R:R310	4.26	No	Yes	21	4	6
792	R:R:M303	R:R:R310	4.96	No	Yes	21	5	6
793	R:R:W306	R:R:Y305	8.68	Yes	No	0	6	4
794	R:R:R310	R:R:W306	12	Yes	Yes	21	6	6
795	R:R:F315	R:R:V319	5.24	No	No	0	4	6
796	R:R:L360	R:R:N320	8.24	No	No	0	9	9
797	R:R:F321	R:R:V325	5.24	No	No	0	6	5
798	R:R:F321	R:R:V365	7.87	No	No	0	6	6
799	R:R:F324	R:R:I328	3.77	No	No	0	9	7
800	R:R:F324	R:R:L356	7.31	No	No	0	9	9
801	R:R:F324	R:R:T362	16.86	No	No	0	9	7
802	R:R:L356	R:R:V327	4.47	No	No	0	9	9
803	R:R:I328	R:R:T353	4.56	No	No	0	7	9
804	R:R:L349	R:R:V332	4.47	No	No	0	9	6
805	R:R:I345	R:R:L335	9.99	No	No	0	5	8
806	R:R:K351	R:R:R348	9.9	No	No	0	8	8
807	R:R:T355	R:R:Y402	3.75	No	Yes	0	8	8
808	R:R:M397	R:R:P358	6.71	No	No	0	5	9
809	R:R:L359	R:R:L360	4.15	No	No	0	9	9
810	R:R:L359	R:R:Y402	22.27	No	Yes	0	9	8
811	R:R:E364	R:R:H363	11.08	No	Yes	0	8	8
812	R:R:H363	R:R:Q394	13.6	Yes	No	0	8	9
813	R:R:F367	R:R:T386	7.78	Yes	No	0	7	4
814	R:R:E387	R:R:F367	5.83	No	Yes	0	8	7
815	R:R:F367	R:R:F390	7.5	Yes	No	0	7	6
816	R:R:M371	R:R:V370	4.56	No	No	0	7	5
817	R:R:E373	R:R:H374	3.69	Yes	No	22	4	3
818	R:R:E373	R:R:T378	7.06	Yes	No	22	4	2
819	R:R:E373	R:R:L379	3.98	Yes	No	22	4	3
820	R:R:E373	R:R:R380	4.65	Yes	Yes	0	4	5
821	R:R:H374	R:R:T378	8.21	No	No	22	3	2
822	R:R:A375	R:R:R376	4.15	No	No	0	4	5
823	R:R:G377	R:R:R380	6	No	Yes	0	4	5
824	R:R:L379	R:R:T378	4.42	No	No	22	3	2
825	R:R:K383	R:R:R380	4.95	No	Yes	0	7	5
826	R:R:L384	R:R:R380	9.72	No	Yes	0	5	5
827	R:R:F381	R:R:I382	3.77	No	No	0	4	4
828	R:R:E387	R:R:K383	5.4	No	No	0	8	7
829	R:R:F385	R:R:S389	3.96	No	No	0	6	5
830	R:R:F390	R:R:S389	3.96	No	No	0	6	5
831	R:R:F390	R:R:M397	4.98	No	No	0	6	5
832	R:R:F393	R:R:L396	4.87	No	No	0	7	7
833	R:R:I400	R:R:L396	4.28	No	No	0	6	7
834	R:R:F404	R:R:I400	3.77	Yes	No	0	8	6
835	R:R:C403	R:R:F404	6.98	No	Yes	0	9	8
836	R:R:E408	R:R:N406	11.83	No	No	0	9	9
837	R:R:N406	R:R:V409	8.87	No	No	0	9	9
838	R:R:E412	R:R:K415	8.1	Yes	No	0	8	7
839	R:R:E418	R:R:R414	12.79	No	No	0	4	6
840	R:R:K415	R:R:R419	8.66	No	No	0	7	7
841	R:R:E418	R:R:W417	11.99	No	No	0	4	5
842	R:R:W417	R:R:W420	3.75	No	No	26	5	4
843	R:R:R421	R:R:W417	13	No	No	26	4	5
844	R:R:R421	R:R:W420	6	No	No	26	4	4
845	B:B:E12	B:B:R8	3.49	No	No	0	4	3
846	B:B:G53	B:B:K89	3.49	No	Yes	0	9	9
847	B:B:G319	B:B:M61	3.49	No	No	0	5	6
848	B:B:C233	B:B:S277	3.44	No	No	0	3	5
849	R:R:C236	R:R:S193	3.44	No	No	0	5	6
850	B:B:C103	B:B:V71	3.42	No	Yes	0	8	8
851	B:B:G115	B:B:L146	3.42	No	No	0	9	7
852	R:R:G285	R:R:L231	3.42	No	No	0	5	5
853	B:B:A11	G:G:V16	3.39	No	No	0	5	7
854	R:R:I357	R:R:P358	3.39	No	No	0	8	9
855	R:R:F367	R:R:H363	3.39	Yes	Yes	0	7	8
856	R:R:G295	R:R:Q221	3.29	No	No	0	4	4
857	R:R:L401	R:R:P358	3.28	No	No	0	8	9
858	B:B:E260	B:B:G224	3.27	No	No	0	6	6
859	A:A:I26	B:B:A92	3.25	No	No	0	9	6
860	A:A:A243	A:A:I288	3.25	No	Yes	0	8	9
861	B:B:A28	B:B:I33	3.25	No	No	0	4	3
862	B:B:I33	G:G:A34	3.25	No	No	0	3	6
863	B:B:A305	B:B:I43	3.25	No	No	0	4	3
864	B:B:A92	B:B:I80	3.25	No	Yes	0	6	8
865	B:B:A140	B:B:I120	3.25	No	No	0	5	6
866	R:R:A238	R:R:I313	3.25	No	No	0	6	7
867	R:R:S352	R:R:V331	3.23	No	No	0	9	8
868	G:G:D48	G:G:P49	3.22	Yes	No	0	9	7
869	A:A:A22	A:A:K25	3.21	No	No	0	4	5
870	B:B:S207	B:B:T223	3.2	No	No	0	5	2
871	R:R:G361	R:R:H363	3.18	No	Yes	0	9	8
872	B:B:L30	G:G:A34	3.15	No	No	0	5	6
873	B:B:A240	G:G:L37	3.15	No	No	0	6	7
874	B:B:A242	B:B:L285	3.15	No	Yes	0	4	6
875	A:A:E330	A:A:P328	3.14	Yes	No	0	3	1
876	B:B:T165	B:B:T179	3.14	No	No	0	7	4
877	B:B:T165	B:B:T181	3.14	No	No	0	7	2
878	B:B:A309	B:B:N293	3.13	No	Yes	0	3	5
879	A:A:S205	B:B:I120	3.1	No	No	0	7	6
880	B:B:I232	B:B:S189	3.1	Yes	No	0	8	7
881	G:G:I9	G:G:S8	3.1	No	No	0	2	4
882	A:A:I245	A:A:V375	3.07	No	No	0	7	9
883	A:A:I288	A:A:V375	3.07	Yes	No	0	9	9
884	B:B:M262	B:B:S31	3.07	Yes	No	0	4	1
885	R:R:I309	R:R:V281	3.07	No	No	0	7	6
886	R:R:I323	R:R:V319	3.07	No	No	0	8	6
887	R:R:I400	R:R:V405	3.07	No	No	0	6	6
888	R:R:A209	R:R:Q210	3.03	No	No	0	1	4
889	A:A:L393	R:R:S352	3	No	No	0	8	9
890	B:B:L4	G:G:S8	3	No	No	0	4	4
891	B:B:L318	B:B:S277	3	No	No	0	6	5
892	R:R:K351	R:R:T355	3	No	No	0	8	8
893	B:B:L285	B:B:V276	2.98	Yes	No	0	6	6
894	R:R:L231	R:R:V281	2.98	No	No	0	5	6
895	R:R:L245	R:R:V319	2.98	No	No	0	8	6
896	B:B:L51	B:B:T87	2.95	Yes	No	0	9	5
897	R:R:D215	R:R:S219	2.94	No	No	0	3	5
898	G:G:A43	G:G:H44	2.93	No	No	0	4	6
899	R:R:I196	R:R:M233	2.92	No	No	0	5	6
900	G:G:I28	G:G:K32	2.91	No	No	0	4	5
901	R:R:I345	R:R:K336	2.91	No	No	0	5	6
902	R:R:I345	R:R:K346	2.91	No	No	0	5	6
903	B:B:F151	B:B:P107	2.89	Yes	No	0	9	6
904	A:A:Q294	A:A:V334	2.87	No	No	0	6	4
905	A:A:E330	A:A:V334	2.85	Yes	No	0	3	4
906	B:B:E10	G:G:V16	2.85	Yes	No	0	8	7
907	R:R:I146	R:R:L142	2.85	No	No	0	4	3
908	R:R:I147	R:R:L388	2.85	No	No	0	6	7
909	R:R:Q211	R:R:T207	2.83	No	No	0	4	3
910	R:R:K346	R:R:L349	2.82	No	No	0	6	9
911	R:R:E364	R:R:T391	2.82	No	No	0	8	6
912	A:A:K293	A:A:N292	2.8	No	Yes	0	9	9
913	B:B:C25	G:G:R27	2.79	No	Yes	0	3	8
914	A:A:A269	A:A:F246	2.77	No	Yes	0	9	9
915	A:A:A337	A:A:F315	2.77	No	No	0	8	6
916	A:A:R385	R:R:A337	2.77	Yes	No	0	5	7
917	B:B:A21	G:G:R27	2.77	No	Yes	0	4	8
918	B:B:A104	B:B:F151	2.77	No	Yes	0	7	9
919	B:B:A113	B:B:F151	2.77	No	Yes	0	9	9
920	B:B:A208	B:B:F241	2.77	No	Yes	0	6	6
921	B:B:K280	G:G:D48	2.77	No	Yes	0	1	9
922	G:G:A10	G:G:R13	2.77	No	No	0	2	6
923	R:R:L307	R:R:L311	2.77	No	No	0	7	4
924	R:R:L311	R:R:L314	2.77	No	No	0	4	4
925	R:R:A399	R:R:F404	2.77	No	Yes	0	8	8
926	R:R:N406	R:R:N407	2.72	No	No	0	9	6
927	A:A:K271	A:A:Q267	2.71	No	No	0	5	4
928	B:B:E12	B:B:K15	2.7	No	No	0	4	6
929	A:A:Y37	B:B:A56	2.67	Yes	No	0	4	7
930	B:B:F199	B:B:V213	2.62	Yes	No	0	9	4
931	R:R:F369	R:R:V365	2.62	No	No	0	4	6
932	R:R:A208	R:R:W214	2.59	No	No	0	4	1
933	R:R:F321	R:R:T362	2.59	No	No	0	6	7
934	R:R:V287	R:R:Y291	2.52	No	No	0	4	3
935	A:A:F340	A:A:I341	2.51	Yes	No	0	7	8
936	B:B:I123	B:B:R137	2.51	Yes	No	12	6	5
937	B:B:I171	B:B:R137	2.51	No	No	12	6	5
938	R:R:F385	R:R:I382	2.51	No	No	0	6	4
939	B:B:K23	B:B:R19	2.48	No	No	0	2	4
940	R:R:L314	R:R:R310	2.43	No	Yes	0	4	6
941	R:R:L335	R:R:R348	2.43	No	No	0	8	8
942	A:A:D223	A:A:F208	2.39	No	No	0	9	5
943	A:A:F312	A:A:Q267	2.34	Yes	No	0	8	4
944	R:R:F381	R:R:Q140	2.34	No	No	0	4	4
945	B:B:R46	R:R:E423	2.33	No	No	0	5	4
946	A:A:F312	A:A:Y311	2.06	Yes	No	0	8	6
947	B:B:C204	B:B:G185	1.96	Yes	No	0	7	5
948	A:A:A226	A:A:G206	1.95	No	No	0	9	8
949	B:B:A193	B:B:P194	1.87	No	No	0	4	4
950	R:R:G216	R:R:S219	1.86	No	No	0	2	5
951	B:B:G306	B:B:V296	1.84	No	No	0	4	5
952	B:B:G182	B:B:T181	1.82	No	No	0	6	2
953	B:B:A60	B:B:C103	1.81	No	No	0	7	8
954	R:R:A158	R:R:A399	1.79	No	No	0	7	8
955	R:R:P283	R:R:V282	1.77	No	No	0	5	3
956	B:B:P107	B:B:T65	1.75	No	No	0	6	1
957	G:G:P53	G:G:T52	1.75	No	No	0	8	4
958	R:R:G285	R:R:K288	1.74	No	No	0	5	8
959	A:A:G47	A:A:L46	1.71	No	No	0	9	8
960	B:B:A28	G:G:S31	1.71	No	No	0	4	9
961	R:R:A158	R:R:S157	1.71	No	No	0	7	3
962	B:B:A26	G:G:V30	1.7	No	No	0	3	8
963	B:B:A231	B:B:V276	1.7	No	No	0	5	6
964	R:R:I308	R:R:P283	1.69	No	No	0	8	5
965	A:A:D354	A:A:G353	1.68	No	No	0	3	4
966	A:A:D354	A:A:G355	1.68	No	No	0	3	2
967	B:B:D246	B:B:G272	1.68	Yes	No	0	9	4
968	B:B:D290	B:B:G272	1.68	Yes	No	0	6	4
969	A:A:E330	A:A:G329	1.64	Yes	No	0	3	7
970	B:B:A248	B:B:I269	1.62	No	Yes	0	5	4
971	R:R:S271	R:R:V270	1.62	No	No	0	3	5
972	R:R:S333	R:R:V332	1.62	No	No	0	7	6
973	B:B:D38	B:B:P39	1.61	No	No	0	1	1
974	A:A:V217	R:R:V259	1.6	No	No	0	5	6
975	B:B:S31	B:B:T29	1.6	No	No	0	1	3
976	R:R:T149	R:R:V150	1.59	No	No	0	7	5
977	R:R:C236	R:R:L232	1.59	No	No	0	5	5
978	B:B:L7	G:G:A12	1.58	No	No	0	8	5
979	B:B:A299	B:B:L285	1.58	No	Yes	0	5	6
980	G:G:A45	G:G:L51	1.58	No	Yes	0	4	6
981	A:A:E327	A:A:P328	1.57	No	No	0	4	1
982	A:A:A249	A:A:N292	1.56	No	Yes	0	8	9
983	R:R:C347	R:R:D344	1.56	No	No	0	7	7
984	R:R:I188	R:R:V160	1.54	No	No	0	7	3
985	R:R:I286	R:R:V282	1.54	No	No	0	4	3
986	R:R:I308	R:R:V287	1.54	No	No	0	8	4
987	R:R:I366	R:R:V370	1.54	No	No	0	6	5
988	R:R:I366	R:R:T362	1.52	No	No	0	6	7
989	A:A:A18	A:A:E21	1.51	No	No	0	4	2
990	R:R:G377	R:R:R376	1.5	No	No	0	4	5
991	R:R:L154	R:R:V150	1.49	No	No	0	5	5
992	R:R:L228	R:R:V229	1.49	No	No	0	4	7
993	G:G:L51	G:G:T52	1.47	Yes	No	0	6	4
994	A:A:N218	A:A:T40	1.46	No	No	0	4	7
995	B:B:A206	B:B:H225	1.46	No	Yes	0	4	9
996	A:A:F312	A:A:P313	1.44	Yes	No	0	8	6
997	A:A:P313	A:A:R317	1.44	No	No	0	6	2
998	G:G:K20	G:G:M21	1.44	No	No	0	6	1
999	R:R:I357	R:R:L354	1.43	No	No	0	8	8
1000	R:R:Q410	R:R:V405	1.43	No	No	0	7	6
1001	R:R:G275	R:R:W274	1.41	No	Yes	0	6	9
1002	B:B:D20	B:B:K23	1.38	No	No	0	2	2
1003	R:R:N302	R:R:N304	1.36	No	No	0	5	3
1004	A:A:E21	A:A:K25	1.35	No	No	0	2	5
1005	B:B:D267	B:B:N268	1.35	No	No	0	3	4
1006	G:G:E17	G:G:K20	1.35	No	No	0	6	6
1007	G:G:E47	G:G:K46	1.35	No	No	0	3	1
1008	B:B:E10	B:B:L7	1.33	Yes	No	0	8	8
1009	G:G:L15	G:G:Q11	1.33	No	No	0	2	3
1010	R:R:L218	R:R:Q221	1.33	No	No	0	3	4
1011	A:A:E15	A:A:N14	1.31	No	No	0	6	3
1012	B:B:D20	B:B:Q17	1.31	No	Yes	0	2	4
1013	R:R:E292	R:R:N302	1.31	No	No	0	6	5
1014	A:A:D229	A:A:E230	1.3	No	No	0	8	9
1015	R:R:L224	R:R:Y289	1.17	No	No	0	3	3
1016	R:R:D293	R:R:Y289	1.15	No	No	0	7	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	A:A:E16	7.4025	4	2	4
2	A:A:Q19	9.705	4	2	4
3	A:A:K34	7.11	4	2	4
4	A:A:Q35	5.9275	4	0	3
5	A:A:Y37	9.37	4	2	4
6	A:A:R38	5.62	4	2	4
7	A:A:F219	7.334	5	0	8
8	A:A:H220	7.8075	4	1	7
9	A:A:F222	9.17	4	1	7
10	A:A:Q227	5.556	5	1	9
11	A:A:K233	6.09	6	1	9
12	A:A:W234	6.17143	7	1	9
13	A:A:F238	8.93	5	0	9
14	A:A:F246	5.294	5	0	9
15	A:A:F273	6.23625	8	7	9
16	A:A:W277	10.59	5	7	6
17	A:A:W281	8.75333	6	1	5
18	A:A:I288	4.9725	4	0	9
19	A:A:F290	6.108	5	16	9
20	A:A:N292	3.295	4	0	9
21	A:A:F312	3.368	5	23	8
22	A:A:E330	3.48	4	0	3
23	A:A:Y339	5.23	4	13	3
24	A:A:F340	9.92667	6	23	7
25	A:A:E344	9.1875	4	23	5
26	A:A:F345	8.6775	4	7	8
27	A:A:R356	10.7375	4	0	2
28	A:A:Y358	7.47	4	0	4
29	A:A:Y360	9.3725	4	0	8
30	A:A:F363	10.215	4	13	5
31	A:A:T364	4.8275	4	16	9
32	A:A:R373	7.755	4	15	5
33	A:A:R374	6.0925	4	16	4
34	A:A:F376	7.8	5	15	8
35	A:A:R385	9.734	5	19	5
36	A:A:H387	8.3525	4	3	8
37	A:A:Y391	5.88667	6	3	4
38	B:B:E10	5.545	4	0	8
39	B:B:Q17	4.1575	4	0	4
40	B:B:I18	4.93	4	0	7
41	B:B:V40	5.4975	4	8	3
42	B:B:R48	6.815	4	2	7
43	B:B:L51	8.0925	4	0	9
44	B:B:H54	9.992	5	2	9
45	B:B:L55	7.8025	4	2	6
46	B:B:K57	10.764	5	1	9
47	B:B:Y59	8.244	5	1	8
48	B:B:W63	6.018	5	0	7
49	B:B:R68	12.76	4	2	5
50	B:B:V71	4.1575	4	6	8
51	B:B:D76	7.9425	4	2	9
52	B:B:K78	5.8425	4	0	8
53	B:B:I80	9.4	4	2	8
54	B:B:W82	11.18	5	2	9
55	B:B:D83	8.6875	4	2	8
56	B:B:T86	7.944	5	2	6
57	B:B:K89	6.07667	6	2	9
58	B:B:L95	5.662	5	6	8
59	B:B:W99	7.84286	7	1	9
60	B:B:M101	6.415	4	1	9
61	B:B:Y105	4.49429	7	6	6
62	B:B:N110	6.455	4	12	4
63	B:B:Y111	6.608	5	12	4
64	B:B:V112	4.5875	4	6	8
65	B:B:C114	5.065	4	6	8
66	B:B:L117	4.8225	4	1	9
67	B:B:N119	4.6525	4	1	9
68	B:B:I123	4.854	5	12	6
69	B:B:Y124	5.58333	6	6	6
70	B:B:H142	8.232	5	9	9
71	B:B:Y145	5.9975	8	1	8
72	B:B:F151	3.56333	6	0	9
73	B:B:D163	7.75	4	9	9
74	B:B:W169	8.77714	7	9	8
75	B:B:D170	7.1975	4	20	9
76	B:B:F180	8.218	5	10	7
77	B:B:H183	9.486	5	0	9
78	B:B:L190	5.26	4	10	5
79	B:B:F199	7.12857	7	10	9
80	B:B:C204	6.21	5	1	7
81	B:B:K209	9.582	5	10	6
82	B:B:L210	6.2825	4	4	5
83	B:B:W211	9.562	5	10	8
84	B:B:Q220	7.318	5	4	7
85	B:B:F222	8.0125	4	4	8
86	B:B:H225	9.36571	7	4	9
87	B:B:D228	9.8425	4	1	9
88	B:B:I232	5.09	4	4	8
89	B:B:F234	6.5325	4	0	5
90	B:B:F235	6.35	5	17	6
91	B:B:P236	6.0175	4	17	7
92	B:B:F241	9.42	5	4	6
93	B:B:T243	6.832	5	4	8
94	B:B:D246	5.2625	4	1	9
95	B:B:D247	8.406	5	4	9
96	B:B:T249	8.2175	4	4	6
97	B:B:R251	10.495	6	4	8
98	B:B:F253	7.72167	6	4	6
99	B:B:D258	8.865	4	4	7
100	B:B:M262	7.7425	4	0	4
101	B:B:Y264	7.866	5	0	5
102	B:B:I269	3.93	5	11	4
103	B:B:F278	5.9725	4	17	7
104	B:B:R283	7.85667	6	8	9
105	B:B:L284	4.7225	4	0	5
106	B:B:L285	3.698	5	0	6
107	B:B:Y289	7.285	6	11	7
108	B:B:D290	6.558	5	1	6
109	B:B:N293	6.2825	4	11	5
110	B:B:N295	7.65833	6	11	6
111	B:B:W297	6.4725	4	11	8
112	B:B:D298	9.4575	4	8	9
113	B:B:R304	8.115	4	11	5
114	B:B:H311	9.438	5	14	9
115	B:B:R314	13.014	5	1	8
116	B:B:W332	11.3857	7	1	9
117	B:B:D333	6.584	5	14	9
118	B:B:K337	10.1375	4	14	6
119	B:B:W339	12.005	4	14	9
120	G:G:E22	6.095	4	0	9
121	G:G:R27	5.524	5	0	8
122	G:G:Y40	12.395	4	17	6
123	G:G:D48	6.926	5	0	9
124	G:G:L51	4.33833	6	8	6
125	G:G:N59	7.918	5	2	9
126	G:G:F61	6.52571	7	2	8
127	R:R:Y145	8.198	5	5	5
128	R:R:Y148	9.1925	4	5	7
129	R:R:Y152	10.384	5	5	7
130	R:R:F156	6.5175	4	0	7
131	R:R:L159	5.0925	4	3	9
132	R:R:F169	7.2225	4	18	7
133	R:R:L172	7.295	4	18	9
134	R:R:R176	5.092	5	3	9
135	R:R:N177	5.7575	4	3	9
136	R:R:H180	6.506	5	3	9
137	R:R:F187	8.72286	7	3	8
138	R:R:R190	9.1425	4	0	8
139	R:R:L201	8.566	5	5	7
140	R:R:K202	6.2275	4	5	4
141	R:R:W203	8.5425	4	5	3
142	R:R:Y220	7.528	5	5	3
143	R:R:N240	9.8025	4	3	9
144	R:R:Y241	8.9375	4	0	8
145	R:R:Y242	6.554	5	25	6
146	R:R:W243	9.72571	7	3	9
147	R:R:E247	7.95	5	3	9
148	R:R:Y250	6.384	5	3	8
149	R:R:L255	4.1425	4	0	8
150	R:R:F266	6.4825	4	0	6
151	R:R:Y269	4.73	5	0	7
152	R:R:W274	9.252	5	3	9
153	R:R:W284	9.2325	4	0	8
154	R:R:W297	11.656	5	5	8
155	R:R:W306	9.7775	4	21	6
156	R:R:R310	5.9125	4	21	6
157	R:R:K334	9.305	4	19	9
158	R:R:H363	7.8125	4	0	8
159	R:R:F367	6.125	4	0	7
160	R:R:E373	4.845	4	22	4
161	R:R:R380	6.33	4	0	5
162	R:R:Y402	9.9	4	3	8
163	R:R:F404	4.3225	4	0	8
164	R:R:E412	10.125	4	18	8
165	W:W:?1	11.7042	12	5	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	A:A:Q19	B:B:D83	44.2333	6.53	Yes	Yes	2	4	8
2	B:B:D83	B:B:T86	44.2263	8.67	Yes	Yes	2	8	6
3	A:A:Q19	B:B:N88	44.121	15.85	Yes	No	2	4	7
4	B:B:N88	B:B:T86	44.2295	8.77	No	Yes	2	7	6
5	A:A:N23	B:B:N88	88.2724	12.26	No	No	2	7	7
6	A:A:N23	B:B:K89	88.0576	5.6	No	Yes	2	7	9
7	B:B:I80	B:B:K89	87.2898	5.82	Yes	Yes	2	8	9
8	B:B:H54	B:B:I80	92.0057	13.26	Yes	Yes	2	9	8
9	B:B:D76	B:B:H54	98.1382	3.78	Yes	Yes	2	9	9
10	B:B:D76	B:B:L55	97.3704	10.86	Yes	Yes	2	9	6
11	A:A:R38	B:B:L55	96.018	4.86	Yes	Yes	2	4	6
12	A:A:R38	R:R:E262	96.1741	4.65	Yes	No	0	4	6
13	B:B:D83	B:B:L69	94.2002	4.07	Yes	No	0	8	5
14	B:B:L69	B:B:Y105	100	5.86	No	Yes	0	5	6
15	B:B:L126	B:B:Y105	36.4925	3.52	No	Yes	6	5	6
16	B:B:K127	B:B:L126	36.7248	4.23	No	No	0	4	5
17	B:B:K127	B:B:N110	36.5667	6.99	No	Yes	0	4	4
18	B:B:N110	B:B:Y111	36.0738	4.65	Yes	Yes	12	4	4
19	B:B:I123	B:B:Y111	34.9925	3.63	Yes	Yes	12	6	4
20	B:B:I123	B:B:L139	32.7444	4.28	Yes	No	0	6	9
21	B:B:L139	B:B:W169	32.0952	15.94	No	Yes	0	9	8
22	B:B:H142	B:B:W169	31.074	7.41	Yes	Yes	9	9	8
23	B:B:H142	B:B:S161	29.5223	16.74	Yes	No	9	9	9
24	B:B:G162	B:B:S161	29.4403	3.71	No	No	0	9	9
25	B:B:G162	B:B:Y145	29.2746	5.79	No	Yes	0	9	8
26	R:R:E262	R:R:F260	96.3272	3.5	No	No	0	6	7
27	R:R:F260	R:R:I265	96.2217	3.77	No	No	0	7	5
28	R:R:I265	R:R:Y269	96.0103	4.84	No	Yes	0	5	7
29	R:R:Y250	R:R:Y269	58.7664	4.96	Yes	Yes	0	8	7
30	R:R:L254	R:R:Y250	21.7332	12.89	No	Yes	0	8	8
31	A:A:H387	R:R:L254	21.5341	18	Yes	No	0	8	8
32	R:R:R176	R:R:Y250	18.8259	4.12	Yes	Yes	3	9	8
33	A:A:Q390	R:R:R176	26.7147	3.5	No	Yes	3	4	9
34	A:A:M386	A:A:Q390	25.3606	5.44	No	No	3	3	4
35	A:A:M386	A:A:R389	42.6889	3.72	No	No	0	3	4
36	A:A:R389	A:A:Y358	42.3049	6.17	No	Yes	0	4	4
37	A:A:Y358	A:A:Y360	13.5973	4.96	Yes	Yes	0	4	8
38	A:A:D378	A:A:Y360	13.6428	14.94	No	Yes	0	7	8
39	A:A:H387	A:A:M386	17.7128	5.25	Yes	No	3	8	3
40	A:A:G355	A:A:Y358	28.4212	4.35	No	Yes	0	2	4
41	A:A:D354	A:A:G355	28.0269	1.68	No	No	0	3	2
42	A:A:D354	A:A:R356	27.2376	10.72	No	Yes	0	3	2
43	A:A:H357	A:A:R356	26.0524	12.41	No	Yes	0	7	2
44	A:A:H357	A:A:W277	25.657	25.39	No	Yes	0	7	6
45	A:A:F273	A:A:W277	22.8556	8.02	Yes	Yes	7	9	6
46	A:A:Y391	R:R:Y250	18.6898	4.96	Yes	Yes	3	4	8
47	B:B:M101	B:B:Y145	18.5818	8.38	Yes	Yes	1	9	8
48	B:B:M101	B:B:Y59	18.0514	7.18	Yes	Yes	1	9	8
49	B:B:W332	B:B:Y59	17.5161	12.54	Yes	Yes	1	9	8
50	A:A:F273	A:A:F345	10.0508	8.57	Yes	Yes	7	9	8
51	A:A:Y391	R:R:E247	17.3249	4.49	Yes	Yes	3	4	9
52	B:B:N313	B:B:W332	16.3333	5.65	No	Yes	0	7	9
53	B:B:D333	B:B:N313	15.9677	4.04	Yes	No	0	9	7
54	B:B:D312	B:B:D333	10.9654	6.65	No	Yes	0	5	9
55	B:B:H62	B:B:Y105	81.5199	4.36	No	Yes	0	6	6
56	B:B:H62	B:B:R150	81.4216	16.93	No	No	0	6	6
57	B:B:C148	B:B:R150	81.3231	5.57	No	No	0	6	6
58	B:B:C148	B:B:L190	81.2244	4.76	No	Yes	0	6	5
59	B:B:F199	B:B:L190	79.962	7.31	Yes	Yes	10	9	5
60	B:B:F199	B:B:W211	77.8126	14.03	Yes	Yes	10	9	8
61	B:B:K209	B:B:W211	39.066	8.12	Yes	Yes	10	6	8
62	B:B:K209	B:B:T221	38.9203	12.01	Yes	No	0	6	7
63	B:B:T221	G:G:E22	38.7931	8.47	No	Yes	0	7	9
64	B:B:C218	B:B:W211	38.7598	5.22	No	Yes	10	5	8
65	B:B:C218	G:G:Q18	38.6347	9.16	No	No	0	5	9
66	G:G:E22	G:G:Q18	38.5076	5.1	Yes	No	0	9	9
67	B:B:I18	G:G:E22	72.2861	6.83	Yes	Yes	0	7	9
68	B:B:I18	B:B:R22	40.5403	3.76	Yes	No	0	7	6
69	B:B:I18	G:G:R27	27.3323	5.01	Yes	Yes	0	7	8
70	B:B:D258	B:B:R22	21.0795	11.91	Yes	No	0	7	6
71	B:B:D258	G:G:R27	21.0559	9.53	Yes	Yes	0	7	8
72	B:B:Q259	B:B:R22	19.2928	5.84	No	No	0	6	6
73	B:B:A257	B:B:Q259	18.3941	4.55	No	No	0	7	6
74	B:B:A257	B:B:D254	18.0943	4.63	No	No	0	7	9
75	B:B:D254	B:B:L261	17.4949	12.21	No	No	0	9	5
76	B:B:R68	B:B:Y85	11.5508	25.72	Yes	No	2	5	4
77	B:B:Y85	G:G:F61	10.0853	7.22	No	Yes	2	4	8
78	B:B:T321	B:B:W63	13.3584	10.92	No	Yes	0	7	7
79	B:B:D323	B:B:T321	12.868	7.23	No	No	24	7	7
80	B:B:D323	B:B:M325	12.6291	8.32	No	No	0	7	5
81	B:B:M325	G:G:P49	12.3857	5.03	No	No	0	5	7
82	G:G:D48	G:G:P49	12.1422	3.22	Yes	No	0	9	7
83	B:B:D258	B:B:Q220	10.2314	10.44	Yes	Yes	4	7	7
84	B:B:L210	B:B:Q220	12.6459	7.99	Yes	Yes	4	5	7
85	B:B:L210	B:B:L255	10.8293	4.15	Yes	No	0	5	6
86	B:B:D258	B:B:F222	31.2763	3.58	Yes	Yes	4	7	8
87	B:B:A193	B:B:F234	13.6078	4.16	No	Yes	0	4	5
88	B:B:F222	B:B:F253	21.0986	9.65	Yes	Yes	4	8	6
89	B:B:F253	B:B:T243	11.5209	9.08	Yes	Yes	4	6	8
90	B:B:L252	B:B:L261	13.5716	4.15	No	No	0	7	5
91	B:B:L252	B:B:Y264	13.2774	5.86	No	Yes	0	7	5
92	B:B:L285	B:B:Y264	10.1931	4.69	Yes	Yes	0	6	5
93	R:R:V246	R:R:Y269	37.4359	5.05	No	Yes	0	8	7
94	R:R:V246	R:R:W243	37.2744	6.13	No	Yes	0	8	9
95	R:R:S186	R:R:W243	34.3008	6.18	No	Yes	3	9	9
96	R:R:N240	R:R:S186	34.4304	5.96	Yes	No	3	9	9
97	R:R:F187	R:R:N240	13.4405	18.12	Yes	Yes	3	8	9
98	R:R:F187	R:R:Q394	13.1367	11.71	Yes	No	0	8	9
99	R:R:H363	R:R:Q394	12.7744	13.6	Yes	No	0	8	9
100	R:R:F367	R:R:H363	12.4582	3.39	Yes	Yes	0	7	8
101	R:R:E247	R:R:L183	20.4963	5.3	Yes	No	3	9	9
102	R:R:F187	R:R:L183	15.0029	4.87	Yes	No	3	8	9
103	R:R:N240	R:R:R190	36.3148	9.64	Yes	Yes	0	9	8
104	R:R:R190	R:R:Y152	35.1761	4.12	Yes	Yes	0	8	7
105	R:R:Y148	R:R:Y152	17.0584	15.89	Yes	Yes	5	7	7
106	R:R:Y148	W:W:?1	16.8368	4.42	Yes	Yes	5	7	0
107	R:R:V194	R:R:Y152	17.0595	16.4	No	Yes	5	7	7
108	R:R:V194	W:W:?1	16.8318	4.01	No	Yes	5	7	0
109	R:R:F230	W:W:?1	13.1978	7.22	No	Yes	0	5	0
110	R:R:F230	R:R:W284	12.2595	5.01	No	Yes	0	5	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:T149	R:R:Y145	8.74	5	No	Yes	7	5	2	1
R:R:D198	R:R:Y145	10.34	5	No	Yes	7	5	2	1
R:R:L201	R:R:Y145	7.03	5	Yes	Yes	7	5	1	1
R:R:K202	R:R:Y145	4.78	5	Yes	Yes	4	5	2	1
R:R:Y145	W:W:?1	10.1	5	Yes	Yes	5	0	1	0
R:R:Y148	R:R:Y152	15.89	5	Yes	Yes	7	7	1	2
R:R:V194	R:R:Y148	8.83	5	No	Yes	7	7	1	1
R:R:S392	R:R:Y148	7.63	5	No	Yes	9	7	2	1
R:R:Y148	W:W:?1	4.42	5	Yes	Yes	7	0	1	0
R:R:D198	R:R:T149	7.23	5	No	No	7	7	2	2
R:R:V194	R:R:Y152	16.4	5	No	Yes	7	7	1	2
R:R:S392	R:R:Y152	10.17	5	No	Yes	9	7	2	2
R:R:V194	W:W:?1	4.01	5	No	Yes	7	0	1	0
R:R:K197	R:R:M233	7.2	0	No	No	6	6	1	2
R:R:K197	W:W:?1	25.07	0	No	Yes	6	0	1	0
R:R:D198	R:R:K202	8.3	5	No	Yes	7	4	2	2
R:R:A200	W:W:?1	10.18	0	No	Yes	4	0	1	0
R:R:K202	R:R:L201	7.05	5	Yes	Yes	4	7	2	1
R:R:L201	R:R:M204	4.24	5	Yes	No	7	3	1	1
R:R:L201	R:R:Y205	14.07	5	Yes	No	7	3	1	2
R:R:L201	W:W:?1	10.44	5	Yes	Yes	7	0	1	0
R:R:K202	R:R:Y205	4.78	5	Yes	No	4	3	2	2
R:R:M204	R:R:W203	4.65	5	No	Yes	3	3	1	1
R:R:T207	R:R:W203	12.13	0	No	Yes	3	3	2	1
R:R:A208	R:R:W203	3.89	0	No	Yes	4	3	2	1
R:R:W203	W:W:?1	13.5	5	Yes	Yes	3	0	1	0
R:R:M204	W:W:?1	12.95	5	No	Yes	3	0	1	0
R:R:L217	W:W:?1	6.71	0	No	Yes	4	0	1	0
R:R:S225	R:R:Y220	7.63	0	No	Yes	3	3	2	1
R:R:C226	R:R:Y220	9.41	5	No	Yes	9	3	2	1
R:R:V229	R:R:Y220	6.31	0	No	Yes	7	3	2	1
R:R:W297	R:R:Y220	4.82	5	Yes	Yes	8	3	1	1
R:R:Y220	W:W:?1	9.47	5	Yes	Yes	3	0	1	0
R:R:Q221	R:R:W297	15.33	0	No	Yes	4	8	2	1
R:R:C226	R:R:C296	7.28	5	No	No	9	9	2	2
R:R:C226	R:R:W297	5.22	5	No	Yes	9	8	2	1
R:R:F230	R:R:Q234	14.05	0	No	No	5	7	1	2
R:R:F230	R:R:W284	5.01	0	No	Yes	5	8	1	2
R:R:F230	W:W:?1	7.22	0	No	Yes	5	0	1	0
R:R:C296	R:R:W297	6.53	5	No	Yes	9	8	2	1
R:R:W297	W:W:?1	26.38	5	Yes	Yes	8	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
38.89	Single	6XOX	Orforglipron	6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
37.50	Single	5NDD	AZ8838; Na	5NDD-PAR2-AZ8838; Na
37.50	Single	8I7W	GSK256073	8I7W-HCA₂-GSK256073-Gi1/&β;1/&γ;2
37.50	Single	8K5D	GSK256073	8K5D-HCA₂-GSK256073
33.33	Single	6RNK	NF-56-EJ40	6RNK-Succinate-NF-56-EJ40
33.33	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
33.33	Single	7LCJ	Danuglipron	7LCJ-GLP-1-Danuglipron
33.33	Single	8IHH	LUF6283	8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2
31.82	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
31.58	Single	6C1R	PMX53	6C1R-C5a₁-PMX53-Avacopan; Na
31.58	Single	7XJK	Galanin	7XJK-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
31.25	Single	7XJJ	Galanin	7XJJ-GAL₁-Galanin-Go/&β;1/&γ;2
31.25	Single	7YK6	PubChem 138319674	7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
31.25	Consensus	go_galanin	Orthosteric Ligand	7XJJ-GAL₁-Galanin-Go/&β;1/&γ;2
30.00	Consensus	gal2_on	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00	Consensus	gs_galanin	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
29.41	Single	6X1A	Danuglipron	6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
29.41	Single	6Z10	PubChem 154585554	6Z10-Succinate-PubChem 154585554
29.41	Single	7LCI	Danuglipron	7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
29.41	Single	7LCK	Danuglipron	7LCK-GLP-1-Danuglipron
29.41	Single	7S15	PubChem 134611223	7S15-GLP-1-PubChem 134611223
29.41	Single	7WQ3	Galanin	7WQ3-GAL₁-Galanin-Gi1/&β;1/&γ;2
29.41	Consensus	gal1_on	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/&β;1/&γ;2
29.41	Consensus	gi_galanin	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/&β;1/&γ;2
29.41	Consensus	hcar_off	Orthosteric Ligand	succinate_off
29.41	Consensus	succinate_off	Orthosteric Ligand	6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
28.57	Single	3OE6	IT1t	3OE6-CXCR4-IT1t
28.57	Single	3OE8	IT1t	3OE8-CXCR4-IT1t
28.57	Single	6C1Q	PMX53	6C1Q-C5a₁-PMX53-NDT9513727
28.57	Single	6OIK	LY2119620	6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
28.57	Consensus	motilin_on	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
27.78	Consensus	rxfp4_on	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
27.27	Single	4XT1	Fractalkine	4XT1-US28-Fractalkine
27.27	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
27.27	Consensus	gi_relaxin	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
26.92	Single	4XT3	Fractalkine	4XT3-US28-Fractalkine
26.67	Single	3OE9	IT1t	3OE9-CXCR4-IT1t
26.67	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
26.32	Single	7XBD	Galanin	7XBD-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.32	Single	8IHB	GSK256073	8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2
26.32	Single	8IYW	GSK256073	8IYW-HCA₂-GSK256073-Go/&β;1/&γ;2
26.32	Consensus	relaxin_on	Orthosteric Ligand	rxfp4_on
26.09	Single	7RKM	Fractalkine	7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
26.09	Single	7W56	Neuromedin-S	7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.93	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
25.81	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
25.00	Single	3ODU	IT1t	3ODU-CXCR4-IT1t
25.00	Single	5ZKQ	ABT-491	5ZKQ-PAF-ABT-491
25.00	Single	7F4H	Afamelanotide	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
25.00	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
25.00	Single	7WQ4	Galanin	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00	Single	8IBU	Erythromycin A	8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00	Single	8IHK	Acifran	8IHK-HCA₃-Acifran
25.00	Consensus	galanin_on	Orthosteric Ligand	gal2_on gal1_on
25.00	Consensus	go_peptide	Orthosteric Ligand	go_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
25.00	Consensus	gs_motilin	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00	Consensus	m2_on_allo	Other Ligand	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
25.00	Consensus	peptide_on	Orthosteric Ligand	opioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
24.00	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
24.00	Consensus	ccr1_on	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
23.81	Single	5UNG	PubChem 15780052	5UNG-AT₂-PubChem 15780052
23.81	Single	7SK7	CCX662	7SK7-ACKR3-CXCL12-CCX662
23.81	Consensus	c5a1_off_ortoallo	Orthosteric Ligand	6C1Q-C5a₁-PMX53-NDT9513727 6C1R-C5a₁-PMX53-Avacopan; Na
23.53	Single	6PT0	WIN 55212-2	6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2
23.53	Single	7TRQ	VU0467154	7TRQ-M₄-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
23.53	Single	7XXH	2MeSADP	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
23.53	Single	8GUQ	Olorinab	8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2
23.53	Single	8J6P	Niacin	8J6P-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
23.53	Single	8JIM	MMF	8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2
23.08	Consensus	gs_ghrelin	Orthosteric Ligand	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.08	Consensus	mc1_on	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
22.73	Single	7F9Z	GHRP-6	7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.73	Single	7RKF	Fractalkine	7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
22.73	Single	8F7R	Endomorphin	8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
22.22	Single	4YAY	ZD-7155	4YAY-AT₁-ZD-7155
22.22	Single	4ZUD	Olmesartan	4ZUD-AT₁-Olmesartan
22.22	Single	5ZKP	Foropafant (SR27417)	5ZKP-PAF-Foropafant (SR27417)
22.22	Single	7NA8	PubChem 178024	7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
22.22	Single	7V3Z	PubMed 104895	7V3Z-CB₁-PubMed 104895
22.22	Single	8I7V	Acipimox	8I7V-HCA₂-Acipimox-Gi1/&β;1/&γ;2
22.22	Single	8JII	Niacin	8JII-HCA₂-Niacin-Compound 9n-Gi1/&β;1/&γ;2
22.22	Consensus	cb1_on_allo	Orthosteric Ligand	7WV9-CB₁-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
22.22	Consensus	gi_hca	Orthosteric Ligand	8H2G-HCA₂-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA₃-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA₂-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2 8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2
22.22	Consensus	gi_hcar	Orthosteric Ligand	gi_hca
22.22	Consensus	hca2_on	Orthosteric Ligand	8H2G-HCA₂-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA₂-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA₂-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA₂-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA₂-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA₂-MMF-Gi1/&β;1/&γ;2 8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA₂-GSK256073-Gi1/&β;1/&γ;2
22.22	Consensus	hca3_on	Orthosteric Ligand	8IHJ-HCA₃-Acifran-Gi1/&β;1/&γ;2
22.22	Consensus	paf_off	Orthosteric Ligand	5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
21.74	Single	5UNF	PubChem 15780052	5UNF-AT₂-PubChem 15780052
21.74	Single	5VBL	Apelin Mimetic Peptide Agonist	5VBL-Apelin-Apelin Mimetic Peptide Agonist
21.74	Consensus	nmur1_on	Orthosteric Ligand	7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
21.74	Consensus	nop_on	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
21.62	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
21.43	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
21.05	Single	8GDA	L902688	8GDA-EP₄-L902688-Gs/&β;1/&γ;2
21.05	Single	8IHJ	Acifran	8IHJ-HCA₃-Acifran-Gi1/&β;1/&γ;2
21.05	Single	8J6J	GSK256073	8J6J-HCA₂-GSK256073-Gi1/&β;1/&γ;2
21.05	Single	8K8J	Fenofibrate	8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
21.05	Consensus	cb2_on	Orthosteric Ligand	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2 8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2
20.83	Single	7EZK	Cholecystokinin-8	7EZK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
20.83	Single	7PIV	Setmelanotide	7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2
20.83	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
20.83	Single	7XBX	CX3CL1	7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
20.69	Single	6PB1	Urocortin	6PB1-CRF₂-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
20.69	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
20.69	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_angiotensin gq_bombesin gq_bradykinin
20.69	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
20.69	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
20.00	Single	6OS1	TRV026	6OS1-AT₁-TRV026
20.00	Single	6W25	SHU9119	6W25-MC₄-SHU9119-Ca
20.00	Single	7AUE	Setmelanotide	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
20.00	Single	7F4D	Alpha-MSH	7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
20.00	Single	7FEE	PubMed 104895	7FEE-CB₁-PubMed 104895-ZCZ011
20.00	Single	7MBX	Cholecystokinin-8	7MBX-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;1
20.00	Single	7W55	Neuromedin-U-25	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00	Single	7WV9	PubMed 104895	7WV9-CB₁-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
20.00	Single	7XJL	Spexin	7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
20.00	Single	7Y67	C089 peptide	7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2
20.00	Single	8GDB	PGE2	8GDB-EP₄-PGE2-Gs/&β;1/&γ;2
20.00	Single	8HQC	C5a anaphylatoxin	8HQC-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
20.00	Single	8JRV	Glucagon	8JRV-Glucagon-Glucagon-Arrestin2
20.00	Consensus	cx3cr1_on	Orthosteric Ligand	7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
20.00	Consensus	gi_peptide	Orthosteric Ligand	gi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
20.00	Consensus	gip_on	Orthosteric Ligand	7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
20.00	Consensus	gip_on_allo	Orthosteric Ligand	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
20.00	Consensus	gs_crf	Orthosteric Ligand	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
20.00	Consensus	mc5_on	Orthosteric Ligand	8INR-MC₅-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
19.35	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
19.35	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
19.23	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue
19.23	Single	6JOD	Angiotensin II	6JOD-AT₂-Angiotensin II
19.23	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
19.23	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
19.23	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
19.23	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
19.23	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
19.23	Consensus	ghrelin_on	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
19.23	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
19.23	Consensus	nmur_on	Orthosteric Ligand	nmur1_on nmur2_on
19.05	Single	6AK3	Dinoprostone IPGE2	6AK3-EP₃-Dinoprostone IPGE2
19.05	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/&β;1/&γ;2
19.05	Single	6KQI	PubMed 104895	6KQI-CB₁-PubMed 104895-ORG27569
19.05	Single	6OS2	TRV026	6OS2-AT₁-TRV026
19.05	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/&β;1/&γ;2
19.05	Single	7D7M	Dinoprostone	7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1
19.05	Single	7F55	Bremelanotide	7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2
19.05	Single	7JNI	Olodanrigan	7JNI-AT₂-Olodanrigan
19.05	Single	7K15	MKD046	7K15-BLT₁-MKD046-Na
19.05	Single	8GCP	PGE2	8GCP-EP₄-PGE2-Gi1/&β;1/&γ;2
19.05	Single	8IA8	E7 peptide	8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2
19.05	Single	8J6D	EP141	8J6D-C3a_B-EP141-Go/&β;1/&γ;2
19.05	Consensus	at2_off	Orthosteric Ligand	7JNI-AT₂-Olodanrigan
19.05	Consensus	blt1_off	Orthosteric Ligand	7K15-BLT₁-MKD046-Na
19.05	Consensus	blt_off	Orthosteric Ligand	blt1_off
19.05	Consensus	cannabinoid_on	Orthosteric Ligand	cb1_on cb2_on
19.05	Consensus	cb1_off_allo	Orthosteric Ligand	6KQI-CB₁-PubMed 104895-ORG27569
19.05	Consensus	cb1_on	Orthosteric Ligand	8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB₁-AM841-Gi1/&β;1/&γ;2 6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2
19.05	Consensus	chemokine_off	Orthosteric Ligand	cxcr_off
19.05	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II
19.05	Consensus	cxcr_off	Orthosteric Ligand	cxcr4_off
19.05	Consensus	ep_on	Orthosteric Ligand	ep4_on ep2_on ep3_on
19.05	Consensus	gi_cannabinoid	Orthosteric Ligand	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2 8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB₂-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB₂-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB₁-AM841-Gi1/&β;1/&γ;2 6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2
19.05	Consensus	gi_prostanoid	Orthosteric Ligand	8GCP-EP₄-PGE2-Gi1/&β;1/&γ;2 8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2 8GCM-EP₄-L902688-Gi1/&β;1/&γ;2
18.75	Single	4MQT	LY2119620	4MQT-M₂-Iperoxo-LY2119620
18.75	Single	7TRP	LY2033298	7TRP-M₄-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
18.75	Single	7XKF	Betahydroxyandrosterone	7XKF-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
18.75	Single	7XP6	Strychnine	7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
18.75	Single	8IHI	Acifran	8IHI-HCA₂-Acifran-Gi1/&β;1/&γ;2
18.75	Single	8JIL	Niacin	8JIL-HCA₂-Niacin-Gi1/&β;1/&γ;2
18.75	Consensus	class-t_on	Orthosteric Ligand	taste2_on
18.75	Consensus	gs_class-t	Orthosteric Ligand	gs_taste
18.75	Consensus	gs_taste	Orthosteric Ligand	7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
18.75	Consensus	m4_on_allo	Other Ligand	7TRP-M₄-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M₄-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M₄-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
18.75	Consensus	taste2_on	Orthosteric Ligand	7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
18.75	Consensus	vip-pacap_on	Orthosteric Ligand	vpac1_on vpac2_on pca1_on
18.52	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
18.52	Single	7V9M	Somatoliberin	7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
18.52	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/&β;1/&γ;2
18.52	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
18.52	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2
18.52	Consensus	gs_melanocortin	Orthosteric Ligand	7F4D-MC₁-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC₄-THIQ-Gs/&β;1/&γ;2
18.52	Consensus	gs_neuromedin	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52	Consensus	vpac1_on	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
18.18	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
18.18	Single	5UNH	PubChem 126456406	5UNH-AT₂-PubChem 126456406
18.18	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/&β;1/&γ;2
18.18	Single	7CX2	PGE2	7CX2-EP₂-PGE2-Gs/&β;1/&γ;2
18.18	Single	7CX4	Evatanepag	7CX4-EP₂-Evatanepag-Gs/&β;1/&γ;2
18.18	Single	7EZM	Cholecystokinin-8	7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
18.18	Single	7MBY	Cholecystokinin-8	7MBY-CCK_A-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
18.18	Single	7P00	Substance P	7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18	Single	7SK8	CCX662	7SK8-ACKR3-CXCL12-CCX662
18.18	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
18.18	Single	7Y65	C5a peptide	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
18.18	Single	8GAG	YVF	8GAG-CB₁-YVF-Gi1/&β;1/&γ;2
18.18	Single	8GUT	LEI-102	8GUT-CB₂-LEI-102-Gi1/&β;1/&γ;2
18.18	Single	8HN1	Toxin AdTx1	8HN1-Alpha1A-Toxin AdTx1
18.18	Single	8WRZ	8D0	8WRZ-CB₁-8D0-Arrestin1
18.18	Single	8XJO	U46619	8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18	Consensus	adgrg2_on	Orthosteric Ligand	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
18.18	Consensus	ep2_on	Orthosteric Ligand	7CX4-EP₂-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP₂-PGE2-Gs/&β;1/&γ;2 7CX3-EP₂-Taprenepag-Gs/&β;1/&γ;2
18.18	Consensus	ep4_on	Orthosteric Ligand	7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP₄-PGE2-Gi1/&β;1/&γ;2 8GD9-EP₄-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP₄-L902688-Gs/&β;1/&γ;2
18.18	Consensus	gs_glucagon	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
18.18	Consensus	gs_vip-pacap	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
17.86	Single	7D3S	Secretin	7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
17.86	Single	7F8V	Gastrin-17	7F8V-CCK_B-Gastrin-17-Gi2/&β;1/&γ;2
17.86	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
17.86	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
17.86	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
17.86	Single	7W3Z	Gastrin Releasing Peptide	7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
17.86	Single	8H0P	NMB30	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
17.86	Consensus	bb1_on	Orthosteric Ligand	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.86	Consensus	ghrh_on	Orthosteric Ligand	7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
17.86	Consensus	gi_compl-peptide	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
17.86	Consensus	glp1_on_allo	Orthosteric Ligand	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
17.86	Consensus	npy4_on	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2
17.65	Single	6LFO	Interleukin-8	6LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
17.65	Single	7T94	PubChem 57664406	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
17.65	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/&β;1/&γ;2
17.65	Single	7XRR	Lemborexant	7XRR-OX₂-Lemborexant
17.65	Single	8HMP	PubChem 69921479	8HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
17.65	Single	8IJB	Acipimox	8IJB-HCA₂-Acipimox-Gi1/&β;1/&γ;2
17.65	Single	8J6L	Niacin	8J6L-HCA₂-Niacin-Gi1/&β;1/&γ;2
17.39	Single	5ZTY	AM10257	5ZTY-CB₂-AM10257
17.39	Single	7RKN	Fractalkine	7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
17.39	Single	7RMG	Substance P	7RMG-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
17.39	Single	7SK9	CCX662	7SK9-ACKR3-CCX662
17.39	Single	7Y1F	Dynorphin	7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
17.39	Single	7YJ4	INSL5	7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
17.39	Single	8INR	Alpha-MSH	8INR-MC₅-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
17.39	Consensus	c3a_on	Orthosteric Ligand	8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2 8I95-C3a_B-EP54-Go/&β;1/&γ;2
17.39	Consensus	cb2_off	Orthosteric Ligand	5ZTY-CB₂-AM10257
17.39	Consensus	class-d_off	Orthosteric Ligand	ste2_off
17.39	Consensus	fpr2-alx_on	Orthosteric Ligand	7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
17.39	Consensus	gi_lipid	Orthosteric Ligand	gi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
17.39	Consensus	go_compl-peptide	Orthosteric Ligand	8I95-C3a_B-EP54-Go/&β;1/&γ;2 8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3a_B-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2
17.39	Consensus	gq_cck	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2
17.39	Consensus	lipid_on	Orthosteric Ligand	cannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
17.39	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
17.39	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
17.39	Consensus	mc4_on	Orthosteric Ligand	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC₄-THIQ-Gs/&β;1/&γ;2 7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
17.39	Consensus	nk1_on	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
17.24	Single	6P9X	Corticoliberin	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
17.24	Single	7F4F	Afamelanotide	7F4F-MC₁-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
17.24	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
17.24	Consensus	ccr_on	Orthosteric Ligand	ccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
17.24	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
16.67	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
16.67	Single	6IGL	IRL1620	6IGL-ET_B-IRL1620
16.67	Single	6IQL	L745870	6IQL-D₄-L745870
16.67	Single	6WJC	Muscarinic toxin 7	6WJC-M₁-Atropine-Muscarinic toxin 7
16.67	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
16.67	Single	6ZA8	RTI-3a	6ZA8-NTS₁-RTI-3a
16.67	Single	6ZDV	PubChem 984073	6ZDV-A_2A-PubChem 984073-Na
16.67	Single	6ZG9	GSK1034702	6ZG9-M₁-GSK1034702
16.67	Single	7C2E	PubChem 149050799	7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
16.67	Single	7CX3	Taprenepag	7CX3-EP₂-Taprenepag-Gs/&β;1/&γ;2
16.67	Single	7F4I	SHU9119	7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
16.67	Single	7F61	PF-03654746	7F61-H₃-PF-03654746-Cholesterol
16.67	Single	7F8X	NN9056	7F8X-CCK_A-NN9056
16.67	Single	7L0R	Neurotensin	7L0R-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
16.67	Single	7QA8	Peptide	7QA8-STE2-Peptide
16.67	Single	7QA8	Peptide	7QA8-STE2-Peptide
16.67	Single	7RMH	Substance P	7RMH-NK₁-Substance P-Gs/&β;1/&γ;2
16.67	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
16.67	Single	7S8P	MS47134	7S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67	Single	7VLA	CCL15(27-92)	7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
16.67	Single	8DWG	ML382	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
16.67	Single	8F7X	Nociceptin	8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
16.67	Single	8GHV	PubChem 145964903	8GHV-CB₁-PubChem 145964903-Gi1/&β;1/&γ;2
16.67	Single	8GUR	PubChem 104895	8GUR-CB₂-PubChem 104895-Gi1/&β;1/&γ;2
16.67	Single	8HNM	VUF11222	8HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
16.67	Single	8J6R	MK6892	8J6R-HCA₂-MK6892-Gi1/&β;1/&γ;2
16.67	Single	8JER	Acipimox	8JER-HCA₂-Acipimox-Go/&β;1/&γ;2
16.67	Single	8JHN	MMF	8JHN-HCA₂-MMF-Go/&β;1/&γ;2
16.67	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
16.67	Single	8K2W	AMG487	8K2W-CXCR3-AMG487
16.67	Single	8K5C	Acipimox	8K5C-HCA₂-Acipimox
16.67	Consensus	at1_off	Orthosteric Ligand	4YAY-AT₁-ZD-7155 4ZUD-AT₁-Olmesartan
16.67	Consensus	class-d_off	Orthosteric Ligand	ste2_off
16.67	Consensus	crf1_on	Orthosteric Ligand	6P9X-CRF₁-Corticoliberin-Gs/&β;1/&γ;2
16.67	Consensus	fpr-alx_on	Orthosteric Ligand	fpr1-alx_on fpr2-alx_on
16.67	Consensus	ghrelin_off	Orthosteric Ligand	6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
16.67	Consensus	gi_chemokine	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
16.67	Consensus	gi_ghrelin	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
16.67	Consensus	glp1_on	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
16.67	Consensus	glucagon_on	Orthosteric Ligand	gip_on glu_on secretin_on ghrh_on glp_on
16.67	Consensus	h3_on_allo	Orthosteric Ligand	7F61-H₃-PF-03654746-Cholesterol
16.67	Consensus	hca_on	Orthosteric Ligand	hca2_on hca3_on
16.67	Consensus	hcar_on	Orthosteric Ligand	hca_on
16.67	Consensus	m1_off_allo	Other Ligand	6WJC-M₁-Atropine-Muscarinic toxin 7
16.67	Consensus	nop_off	Orthosteric Ligand	4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
16.67	Consensus	s1p1_off	Orthosteric Ligand	3V2Y-S1P₁-PubChem 51892645
16.67	Consensus	s1p_off	Orthosteric Ligand	s1p1_off
16.67	Consensus	secretin_on	Orthosteric Ligand	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
16.67	Consensus	sst_on	Orthosteric Ligand	sst2_on sst4_on
16.13	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
16.13	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
16.13	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
16.13	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
16.13	Consensus	bb2_on	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
16.13	Consensus	gq_bombesin	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
16.00	Single	5XJM	(Sar1,Ile8)-Angiotensin II	5XJM-AT₂-(Sar1,Ile8)-Angiotensin II
16.00	Single	6DO1	Angiotensin-Like peptide S1I8	6DO1-AT₁-Angiotensin-Like peptide S1I8
16.00	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
16.00	Single	7PIU	Setmelanotide	7PIU-MC₄-Setmelanotide-Gs/&β;1/&γ;2
16.00	Single	7XMS	Somatostatin-14	7XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
16.00	Single	8F7Q	Beta-endorphin	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
16.00	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
16.00	Single	8SG1	Chemerin-9	8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
16.00	Consensus	alpha1_off	Orthosteric Ligand	alpha1a_off alpha1b_off
16.00	Consensus	cx3cr_on	Orthosteric Ligand	cx3cr1_on
16.00	Consensus	gi_cck	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCK_B-Gastrin-17-Gi2/&β;1/&γ;2
16.00	Consensus	gi_lpl	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
16.00	Consensus	sst_off	Orthosteric Ligand	sst2_off
15.79	Single	4EA3	PubChem 10296561	4EA3-NOP-PubChem 10296561
15.79	Single	5DHG	PubChem 25001412	5DHG-NOP-PubChem 25001412
15.79	Single	5T04	Neurotensin	5T04-NTS₁-Neurotensin
15.79	Single	6KPF	PubChem 145915889	6KPF-CB₂-PubChem 145915889-Gi1/&β;1/&γ;2
15.79	Single	6TOT	Lemborexant	6TOT-OX₁-Lemborexant
15.79	Single	6Z4V	NTS8-13	6Z4V-NTS₁-NTS8-13
15.79	Single	7F83	PF-05190457	7F83-Ghrelin-PF-05190457
15.79	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/&β;1/&γ;2
15.79	Single	7VIF	(S)-FTY720-P	7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2
15.79	Single	7YAC	Paltusotine	7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
15.79	Single	7YK7	DC591053	7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
15.79	Single	8EFQ	Damgo	8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
15.79	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off leuko_off lpl_off paf_off prostanoid_off
15.79	Consensus	prostanoid_off	Orthosteric Ligand	ep_off tp_off dp_off
15.62	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/&β;1/&γ;1
15.62	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
15.62	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
15.62	Single	8HBD	IRL1620	8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
15.62	Consensus	melanocortin_on	Orthosteric Ligand	mc2_on mc1_on mc3_on mc4_on mc5_on
15.38	Single	6W25	Ca	6W25-MC₄-SHU9119-Ca
15.38	Single	7O7F	(6P4)CCL5	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
15.38	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
15.38	Single	7XNA	CYN154806	7XNA-SST2-CYN154806
15.38	Single	7XOU	Cholecystokinin-8	7XOU-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;2
15.38	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/&β;1/&γ;2
15.38	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
15.38	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
15.38	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
15.38	Consensus	gi_chemerin	Orthosteric Ligand	8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
15.38	Consensus	gi_formylpeptide	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
15.38	Consensus	gs_tachykinin	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38	Consensus	opioid_on	Orthosteric Ligand	kop_on mop_on nop_on dop_on
15.38	Consensus	sst2_off	Orthosteric Ligand	7XNA-SST2-CYN154806
15.15	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
15.15	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
15.00	Single	5T1A	PubChem 68764898; PubChem 12093170	5T1A-CCR2-PubChem 68764898; PubChem 12093170
15.00	Single	5YHL	PubChem 135121352	5YHL-EP₄-PubChem 135121352
15.00	Single	5YWY	ONO-AE3-208	5YWY-EP₄-ONO-AE3-208
15.00	Single	6D26	Fevipiprant	6D26-DP₂-Fevipiprant
15.00	Single	6KPC	PubChem 145915889	6KPC-CB₂-PubChem 145915889
15.00	Single	6M9T	Misoprostol-FA	6M9T-EP₃-Misoprostol-FA
15.00	Single	6N4B	MDMB-Fubinaca	6N4B-CB₁-MDMB-Fubinaca-Gi1/&β;1/&γ;2
15.00	Single	6Z8N	SRI-9829	6Z8N-NTS₁-SRI-9829
15.00	Single	7C4S	S1P	7C4S-S1P₃-S1P
15.00	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/&β;1/&γ;2
15.00	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2
15.00	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2
15.00	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
15.00	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
15.00	Single	8FN1	Neurotensin/neuromedin N	8FN1-NTS₁-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
15.00	Single	8GDC	PGE2	8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2
15.00	Single	8HNL	PS372424	8HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
15.00	Single	8JPC	Neurotensin 8-13	8JPC-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
15.00	Consensus	ccr2_off_allo	Other Ligand	5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
15.00	Consensus	ep3_on	Orthosteric Ligand	8GDC-EP₃-PGE2-Gi1/&β;1/&γ;2
15.00	Consensus	ep4_off	Orthosteric Ligand	5YWY-EP₄-ONO-AE3-208 5YHL-EP₄-PubChem 135121352
15.00	Consensus	ep_off	Orthosteric Ligand	ep4_off
14.81	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
14.81	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
14.81	Single	7W40	Bombesin	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
14.81	Single	7WUI	IP15	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
14.81	Single	8IHF	MK6892	8IHF-HCA₂-MK6892-Gi1/&β;1/&γ;2
14.81	Single	8J6I	MK6892	8J6I-HCA₂-MK6892-Gi1/&β;1/&γ;2
14.81	Consensus	class-d_on	Orthosteric Ligand	ste2_on
14.81	Consensus	gi_class-d	Orthosteric Ligand	gi_ste
14.81	Consensus	gi_somatostatin	Orthosteric Ligand	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
14.81	Consensus	gi_ste	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
14.81	Consensus	nmur2_on	Orthosteric Ligand	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81	Consensus	pca1_on	Orthosteric Ligand	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
14.71	Consensus	gi_neuropeptide	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
14.71	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
14.29	Single	3ZEV	Neurotensin	3ZEV-NTS₁-Neurotensin
14.29	Single	4BV0	Neurotensin	4BV0-NTS₁-Neurotensin
14.29	Single	5XR8	AM841	5XR8-CB₁-AM841
14.29	Single	5XRA	AM11542	5XRA-CB₁-AM11542
14.29	Single	6KO5	PubChem 57400002	6KO5-Ghrelin-PubChem 57400002
14.29	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
14.29	Single	7L0P	Neurotensin	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
14.29	Single	7L0Q	Neurotensin	7L0Q-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
14.29	Single	7M8W	15r-Methyl-Prostaglandin D2	7M8W-DP₂-15r-Methyl-Prostaglandin D2-Na
14.29	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
14.29	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-Alpha-factor mating pheromone
14.29	Single	7R0C	Acyclovir triphosphate	7R0C-V₂-Acyclovir triphosphate-Arrestin2
14.29	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
14.29	Single	7TUY	GSK682753A	7TUY-GPR183-GSK682753A
14.29	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2
14.29	Single	7X9C	Pancreatic Hormone	7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2
14.29	Single	7XTQ	R399	7XTQ-GPBA-R399-Gs/&β;1/&γ;2
14.29	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2
14.29	Single	8EF5	Fentanyl	8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
14.29	Single	8EFL	SR17018	8EFL-μ-SR17018-Gi1/&β;1/&γ;2
14.29	Single	8GUS	HU-308	8GUS-CB₂-HU-308-Gi1/&β;1/&γ;2
14.29	Single	8IOD	PG-901	8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
14.29	Single	8JT6	(R)-IHCH-7179	8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
14.29	Single	8KH5	Lysophosphatidylserine	8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
14.29	Consensus	angiotensin_off	Orthosteric Ligand	at1_off at2_off
14.29	Consensus	bombesin_on	Orthosteric Ligand	bb2_on bb1_on
14.29	Consensus	c5a1_on	Orthosteric Ligand	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
14.29	Consensus	cck_on	Orthosteric Ligand	ccka_on cckb_on
14.29	Consensus	ccka_on	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2
14.29	Consensus	chemerin_on	Orthosteric Ligand	cml1_on
14.29	Consensus	cml1_on	Orthosteric Ligand	8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
14.29	Consensus	gs_class-b	Orthosteric Ligand	gs_class-b1 gs_class-b2
14.29	Consensus	nts1_on_allo	Orthosteric Ligand	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
14.29	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
14.29	Consensus	sst4_on	Orthosteric Ligand	7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
13.79	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
13.79	Single	6FJ3	PTH	6FJ3-PTH1-PTH
13.79	Single	6P9Y	PACAP	6P9Y-PAC₁-PACAP-Gs/&β;1/&γ;2
13.79	Single	7CZ5	Somatoliberin	7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
13.79	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
13.79	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
13.79	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-Alpha-factor mating pheromone
13.79	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
13.79	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
13.79	Single	7XV3	Lysophosphatidylserine	7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
13.79	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
13.79	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
13.79	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
13.79	Consensus	class-d_on	Orthosteric Ligand	ste2_on
13.79	Consensus	gi_neuromedin	Orthosteric Ligand	7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
13.64	Single	4GRV	Neurotensin 8-13	4GRV-NTS₁-Neurotensin 8-13
13.64	Single	4XEE	Neurotensin	4XEE-NTS₁-Neurotensin
13.64	Single	4XES	Neurotensin	4XES-NTS₁-Neurotensin
13.64	Single	5X33	BIIL260	5X33-BLT₁-BIIL260
13.64	Single	6IIU	Ramatroban	6IIU-TP-Ramatroban
13.64	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
13.64	Single	6YVR	NTS8-13	6YVR-NTS₁-NTS8-13
13.64	Single	6ZG4	HTL0009936	6ZG4-M₁-HTL0009936
13.64	Single	7DFP	Spiperone	7DFP-D₂-Spiperone
13.64	Single	7EO4	BAF312	7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2
13.64	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
13.64	Single	7L1V	PubChem 155491009	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64	Single	7XMT	J-2156	7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
13.64	Single	7Y66	BM213	7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2
13.64	Single	7YMJ	Tamsulosin	7YMJ-Alpha1A-Tamsulosin
13.64	Single	8H0Q	Gastrin Releasing Peptide	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64	Single	8HK2	C3a anaphylatoxin	8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2
13.64	Single	8I95	EP54	8I95-C3a_B-EP54-Go/&β;1/&γ;2
13.64	Single	8I9L	C3a anaphylatoxin	8I9L-C3a_B-C3a anaphylatoxin-Go/&β;1/&γ;2
13.64	Single	8JPB	Neurotensin 8-13	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
13.64	Single	8JWZ	AB928	8JWZ-A_2A-AB928-Na
13.64	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2
13.64	Single	8WU1	KCA	8WU1-CB₁-KCA-Arrestin1
13.64	Consensus	adgrg_on	Orthosteric Ligand	adgrg2_on adgrg3_on
13.64	Consensus	cannabinoid_off	Orthosteric Ligand	cb1_off cb2_off
13.64	Consensus	class-b2_on	Orthosteric Ligand	adgrg_on
13.64	Consensus	dp2_off	Orthosteric Ligand	6D27-DP₂-CAY10471 6D26-DP₂-Fevipiprant
13.64	Consensus	dp_off	Orthosteric Ligand	dp2_off
13.64	Consensus	gpr119_on	Orthosteric Ligand	7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
13.64	Consensus	gs_bileacid	Orthosteric Ligand	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
13.64	Consensus	gs_steroid	Orthosteric Ligand	gs_bileacid
13.64	Consensus	mop_on	Orthosteric Ligand	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
13.64	Consensus	s1p_on	Orthosteric Ligand	s1p3_on s1p5_on s1p1_on s1p2_on
13.51	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
13.33	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
13.33	Single	6TQ9	SB-408124	6TQ9-OX₁-SB-408124
13.33	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
13.33	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.33	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/&β;1/&γ;2
13.33	Single	7F53	Alpha-MSH	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2
13.33	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-Alpha-factor mating pheromone
13.33	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
13.33	Single	7WVY	Amyloid-Beta42	7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
13.33	Single	7XK8	Neuromedin-U-25	7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
13.33	Single	7XKD	Betahydroxyandrosterone	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
13.33	Single	7YOO	Neuropeptide Y	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
13.33	Single	8HVI	NOX-6-7	8HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
13.33	Consensus	endothelin_on	Orthosteric Ligand	etb_on eta_on
13.33	Consensus	etb_on	Orthosteric Ligand	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
13.33	Consensus	gi_class-d	Orthosteric Ligand	gi_ste
13.33	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
13.33	Consensus	gi_ste	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.16	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on calcitonin_on vip-pacap_on pth_on crf_on
13.04	Single	4BUO	Neurotensin	4BUO-NTS₁-Neurotensin
13.04	Single	6K1Q	IRL2500	6K1Q-ET_B-IRL2500
13.04	Single	7EZH	Cholecystokinin-8	7EZH-CCK_A-Cholecystokinin-8-Gi1/&β;1/&γ;2
13.04	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
13.04	Single	7XZ6	APD668	7XZ6-GPR119-APD668-Gs/&β;1/&γ;2
13.04	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
13.04	Single	8IUL	Latanoprost	8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04	Single	8JPF	Neurotensin	8JPF-NTS₁-Neurotensin-PubChem 118610427
13.04	Single	8K2X	CXCL10	8K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
13.04	Consensus	bileacid_on	Orthosteric Ligand	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
13.04	Consensus	endothelin_off	Orthosteric Ligand	etb_off
13.04	Consensus	etb_off	Orthosteric Ligand	5XPR-ET_B-Bosentan 6K1Q-ET_B-IRL2500 5X93-ET_B-K-8794
13.04	Consensus	gi_neurotensin	Orthosteric Ligand	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
13.04	Consensus	gs_cck	Orthosteric Ligand	7MBX-CCK_A-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2
13.04	Consensus	gs_lipid	Orthosteric Ligand	gs_ffa gs_prostanoid
13.04	Consensus	gs_orexin	Orthosteric Ligand	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
13.04	Consensus	gs_prostanoid	Orthosteric Ligand	8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP₂-PGE2-Gs/&β;1/&γ;2 7CX3-EP₂-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP₄-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP₂-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04	Consensus	orexin_on	Orthosteric Ligand	ox2_on
13.04	Consensus	s1p1_on	Orthosteric Ligand	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
13.04	Consensus	steroid_on	Orthosteric Ligand	bileacid_on
12.90	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
12.90	Single	6LML	Glucagon	6LML-Glucagon-Glucagon
12.90	Single	6NBH	Long-acting PTH analog	6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
12.90	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
12.90	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
12.90	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-Alpha-factor mating pheromone
12.90	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
12.90	Single	7VGX	Neuropeptide Y	7VGX-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
12.90	Single	8FEG	PRD_002517	8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
12.90	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
12.50	Single	5EE7	MK0893	5EE7-Glucagon-MK0893
12.50	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
12.50	Single	6OMM	WKYMVX	6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
12.50	Single	6PB0	Urocortin	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
12.50	Single	7D77	Hydrocortisone	7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
12.50	Single	7F2O	Bradykinin	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50	Single	7F8W	Gastrin-17	7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
12.50	Single	7S8L	Cortistatin-14	7S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
12.50	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/&β;1/&γ;2
12.50	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/&β;1/&γ;2
12.50	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
12.50	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
12.50	Single	8IYH	MK6892	8IYH-HCA₂-MK6892-Go/&β;1/&γ;2
12.50	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50	Single	8JLR	A77636	8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
12.50	Single	8XZF	WN561	8XZF-Apelin-WN561-Gi1/&β;1/&γ;2
12.50	Consensus	adgrg3_on	Orthosteric Ligand	7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
12.50	Consensus	chemokine_on	Orthosteric Ligand	cxcr_on cx3cr_on
12.50	Consensus	dop_on	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
12.50	Consensus	fpr1-alx_on	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
12.50	Consensus	gi_apelin	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
12.50	Consensus	go_ghrelin	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
12.50	Consensus	gs_adgr	Orthosteric Ligand	7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
12.50	Consensus	gs_bombesin	Orthosteric Ligand	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50	Consensus	gs_class-b1	Orthosteric Ligand	gs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
12.50	Consensus	gs_class-b2	Orthosteric Ligand	gs_adgr
12.50	Consensus	ox2_on	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
12.50	Consensus	ste2_off	Orthosteric Ligand	7QA8-STE2-Peptide
12.12	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
12.12	Consensus	gi_endothelin	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ET_B-IRL1620-Gi1/&β;1/&γ;2
12.00	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
12.00	Single	7T6U	CGEN-855A	7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
12.00	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2
12.00	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
12.00	Single	7W53	Neuromedin-U-25	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00	Single	7XMR	Somatostatin-14	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
12.00	Single	8DCR	Dobutamine	8DCR-β₁-Dobutamine-Gs/&β;1/&γ;2
12.00	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/&β;1/&γ;2
12.00	Consensus	alpha1a_off	Orthosteric Ligand	7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
12.00	Consensus	apelin_on	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
12.00	Consensus	gi_opioid	Orthosteric Ligand	8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
12.00	Consensus	protein_off	Orthosteric Ligand	ccr_off chemokine_off gnrh_off
12.00	Consensus	sst2_on	Orthosteric Ligand	7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
12.00	Consensus	ste2_off	Orthosteric Ligand	7QA8-STE2-Peptide
11.76	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
11.76	Single	5OLV	LUAA41063	5OLV-A_2A-LUAA41063-Na
11.76	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
11.76	Single	6U1N	LY2119620	6U1N-M₂-LY2119620-Arrestin2
11.76	Single	7D76	Beclomethasone	7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
11.76	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
11.76	Single	8A2P	LUAA47070	8A2P-A_2A-LUAA47070-Na
11.76	Single	8H2G	Niacin	8H2G-HCA₂-Niacin-Gi1/&β;1/&γ;2
11.76	Single	8H8J	Lodoxamide	8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
11.76	Single	8IJA	Niacin	8IJA-HCA₂-Niacin-Gi1/&β;1/&γ;2
11.76	Single	8K5B	Niacin	8K5B-HCA₂-Niacin
11.76	Consensus	go_adhesion	Orthosteric Ligand	7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
11.76	Consensus	go_class-b2	Orthosteric Ligand	go_adhesion
11.76	Consensus	pth1_on	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
11.54	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
11.54	Single	7F1Q	MIP-1a	7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
11.54	Single	7RMI	Substance P	7RMI-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
11.54	Single	7SK5	CXCL12	7SK5-ACKR3-CXCL12
11.54	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
11.54	Single	8F7S	Deltorphin	8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
11.54	Single	8IOC	Gamma-MSH	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.43	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
11.43	Single	7X9A	Neuropeptide Y	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
11.43	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
11.43	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
11.43	Consensus	npy1_on	Orthosteric Ligand	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
11.43	Consensus	npy_on	Orthosteric Ligand	npy2_on npy4_on npy1_on
11.11	Single	4BWB	Neurotensin	4BWB-NTS₁-Neurotensin
11.11	Single	4S0V	Suvorexant	4S0V-OX₂-Suvorexant
11.11	Single	5DHH	SB-612111	5DHH-NOP-SB-612111
11.11	Single	5U09	Taranabant	5U09-CB₁-Taranabant
11.11	Single	5WS3	EMPA	5WS3-OX₂-EMPA
11.11	Single	6AKX	A4R	6AKX-CCR5-A4R
11.11	Single	6AKY	Maraviroc	6AKY-CCR5-Maraviroc
11.11	Single	6B73	PubChem 131955138	6B73-κ-PubChem 131955138
11.11	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
11.11	Single	6TPJ	Suvorexant	6TPJ-OX₂-Suvorexant
11.11	Single	7F8Y	Devazepide	7F8Y-CCK_A-Devazepide
11.11	Single	7T6T	fMLFII	7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
11.11	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2
11.11	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/&β;1/&γ;2
11.11	Single	7VDL	Cortistatin-14	7VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
11.11	Single	7W0O	Elabela	7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
11.11	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/&β;1/&γ;2
11.11	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
11.11	Single	7XAU	Octreotide	7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
11.11	Single	8DWH	Compound-16	8DWH-MRGPRX1-Compound-16-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11	Single	8EFO	PZM21	8EFO-μ-PZM21-Gi1/&β;1/&γ;2
11.11	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
11.11	Single	8U4P	AMD3100	8U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
11.11	Single	8XZG	Apelin-13	8XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
11.11	Consensus	ccr_off	Orthosteric Ligand	ccr5_off ccr8_off
11.11	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.11	Consensus	orexin_off	Orthosteric Ligand	ox2_off ox1_off
11.11	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on
10.81	Single	8F2A	Pramlintide analogue san385	8F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
10.81	Consensus	ct_on	Orthosteric Ligand	7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
10.71	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
10.71	Single	6MEO	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
10.71	Single	6MET	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
10.71	Single	6NIY	Adrenomedullin	6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
10.71	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
10.71	Single	7C61	Ergotamine	7C61-5-HT_1B-Ergotamine
10.71	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.71	Single	7YON	Peptide YY(3-36)	7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
10.71	Consensus	bk2_on	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
10.71	Consensus	ste2_on	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
10.53	Single	4MBS	Maraviroc	4MBS-CCR5-Maraviroc
10.53	Single	4ZJC	SB-674042	4ZJC-OX₁-SB-674042
10.53	Single	6TOS	GSK1059865	6TOS-OX₁-GSK1059865-Na
10.53	Single	6TP3	Nemorexant	6TP3-OX₁-Nemorexant
10.53	Single	6TPG	EMPA	6TPG-OX₂-EMPA
10.53	Single	6V9S	GTPL11403	6V9S-OX₁-GTPL11403
10.53	Single	6ZFZ	77-LH-28-1	6ZFZ-M₁-77-LH-28-1
10.53	Single	7SR8	TAK-925	7SR8-OX₂-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.53	Single	7XOV	SR146131	7XOV-CCK_A-SR146131-Gs/&β;1/&γ;2
10.53	Single	8GCM	L902688	8GCM-EP₄-L902688-Gi1/&β;1/&γ;2
10.53	Single	8JLQ	Fenoldopam	8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
10.53	Single	8X7A	Treprostinil	8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
10.53	Consensus	cb1_off	Orthosteric Ligand	5TGZ-CB₁-AM6538 5U09-CB₁-Taranabant
10.53	Consensus	ox1_off	Orthosteric Ligand	6TOT-OX₁-Lemborexant 6TP4-OX₁-ACT-462206 6TP6-OX₁-Filorexant 6V9S-OX₁-GTPL11403 6TP3-OX₁-Nemorexant 6TQ6-OX₁-PubChem 145714283 6TQ7-OX₁-SB-334867 6TQ9-OX₁-SB-408124 4ZJC-OX₁-SB-674042 4ZJ8-OX₁-Suvorexant
10.53	Consensus	ox2_off	Orthosteric Ligand	6TPN-OX₂-HTL6641 7XRR-OX₂-Lemborexant
10.34	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2
10.34	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
10.34	Single	7KH0	Acyclovir triphosphate	7KH0-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
10.34	Single	7X9B	Neuropeptide Y	7X9B-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
10.34	Single	7XAT	Somatostatin-14	7XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
10.34	Single	7YKD	Chemerin-9	7YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
10.34	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2
10.34	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.34	Single	8HCX	Endothelin-1	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.34	Consensus	bk1_on	Orthosteric Ligand	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.34	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
10.34	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.34	Consensus	gq_class-a	Orthosteric Ligand	gq_amine gq_peptide
10.34	Consensus	gs_bradykinin	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.26	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
10.00	Single	4QIM	PubChem 24905375	4QIM-SMO-PubChem 24905375
10.00	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
10.00	Single	5UIG	J3.651.884G	5UIG-A_2A-J3.651.884G
10.00	Single	6D27	CAY10471	6D27-DP₂-CAY10471
10.00	Single	6DRX	Lisuride	6DRX-5-HT_2B-Lisuride
10.00	Single	6GPS	MK0812	6GPS-CCR2-MK0812
10.00	Single	6IIV	Daltroban	6IIV-TP-Daltroban
10.00	Single	6NBF	Long-acting PTH analog	6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
10.00	Single	6NBI	Long-acting PTH analog	6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
10.00	Single	7CFM	P395	7CFM-GPBA-P395-Gs/&β;1/&γ;2
10.00	Single	7SCG	FH210	7SCG-μ-FH210-Gi1/&β;1/&γ;2
10.00	Single	7SQO	TAK-925	7SQO-OX₂-TAK-925-Gi1/&β;1/&γ;2
10.00	Single	7T2G	Mitragynine pseudoindoxyl	7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
10.00	Single	7T6V	fMLFII	7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
10.00	Single	7UL4	Alvimopan	7UL4-μ-Alvimopan
10.00	Single	7VKT	LTB4	7VKT-BLT₁-LTB4-Gi1/&β;1/&γ;2
10.00	Single	7W57	Neuromedin-S	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
10.00	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/&β;1/&γ;2
10.00	Single	8EJC	TAK-875	8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.00	Single	8EJK	TAK-875	8EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.00	Single	8KFY	ZK-756326	8KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
10.00	Single	8XJL	PGF2-alpha	8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
10.00	Consensus	blt1_on	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/&β;1/&γ;2
10.00	Consensus	blt_on	Orthosteric Ligand	blt1_on
10.00	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on bk1_on
10.00	Consensus	cck_off	Orthosteric Ligand	ccka_off
10.00	Consensus	ccka_off	Orthosteric Ligand	7F8Y-CCK_A-Devazepide 7F8U-CCK_A-Lintitript
10.00	Consensus	gi_leukotriene	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/&β;1/&γ;2
10.00	Consensus	gs_ct	Orthosteric Ligand	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
10.00	Consensus	leuko_on	Orthosteric Ligand	blt_on
10.00	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
10.00	Consensus	tp_off	Orthosteric Ligand	6IIV-TP-Daltroban 6IIU-TP-Ramatroban
9.68	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
9.68	Single	7EIB	Des-Arg10-Kallidin	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.68	Consensus	ccr8_on	Orthosteric Ligand	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
9.68	Consensus	go_class-b1	Orthosteric Ligand	go_crf
9.68	Consensus	go_crf	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
9.68	Consensus	ste2_on	Orthosteric Ligand	7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
9.52	Single	4JKV	Taladegib (LY2940680)	4JKV-SMO-Taladegib (LY2940680)
9.52	Single	4WW3	All-trans-retinal	4WW3-Rhodopsin-All-trans-retinal
9.52	Single	4ZJ8	Suvorexant	4ZJ8-OX₁-Suvorexant
9.52	Single	5WIU	Nemonapride	5WIU-D₄-Nemonapride
9.52	Single	5WIV	Nemonapride	5WIV-D₄-Nemonapride-Na
9.52	Single	5WQC	EMPA	5WQC-OX₂-EMPA
9.52	Single	6DDE	Damgo	6DDE-μ-Damgo-Gi1/&β;1/&γ;2
9.52	Single	6GPX	MK0812	6GPX-CCR2-MK0812
9.52	Single	6TO7	Suvorexant	6TO7-OX₁-Suvorexant-Na
9.52	Single	6TP6	Filorexant	6TP6-OX₁-Filorexant
9.52	Single	7BB7	Acyclovir triphosphate	7BB7-V₂-Acyclovir triphosphate-Gs/&β;1/&γ;2
9.52	Single	7CFN	INT-777	7CFN-GPBA-INT-777-Gs/&β;1/&γ;2
9.52	Single	7SBF	PZM21	7SBF-μ-PZM21-Gi1/&β;1/&γ;2
9.52	Single	7VFX	fMLF	7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
9.52	Single	7VV4	Cortistatin-14	7VV4-MRGPRX2-Cortistatin-14
9.52	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
9.52	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
9.52	Single	8DZQ	momSalB	8DZQ-κ-momSalB-Go/&β;1/&γ;2
9.52	Single	8DZR	GR89,696	8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
9.52	Single	8EFB	Oliceridine	8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
9.52	Single	8F0J	Pramlintide analogue san45	8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2
9.52	Single	8GD9	Rivenprost	8GD9-EP₄-Rivenprost-Gs/&β;1/&γ;2
9.52	Single	8KFX	LMD-009	8KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
9.52	Consensus	d4_off	Orthosteric Ligand	5WIU-D₄-Nemonapride
9.52	Consensus	d4_off_allo	Orthosteric Ligand	5WIV-D₄-Nemonapride-Na
9.52	Consensus	go_opioid	Orthosteric Ligand	8DZQ-κ-momSalB-Go/&β;1/&γ;2
9.38	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
9.38	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
9.38	Consensus	gs_endothelin	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09	Single	4DJH	JDTic	4DJH-κ-JDTic
9.09	Single	4RWA	DIPP-NH2	4RWA-δ-DIPP-NH2
9.09	Single	4RWD	DIPP-NH2	4RWD-δ-DIPP-NH2-Na
9.09	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
9.09	Single	5TZR	-	5TZR-FFA1 (GPR40)-MK8666
9.09	Single	5V56	TC114	5V56-SMO-TC114
9.09	Single	5V57	TC114	5V57-SMO-TC114
9.09	Single	5X93	K-8794	5X93-ET_B-K-8794
9.09	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
9.09	Single	6TQ7	SB-334867	6TQ7-OX₁-SB-334867
9.09	Single	6UP7	Neurotensin	6UP7-NTS₁-Neurotensin-Arrestin2
9.09	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
9.09	Single	7B6W	Cyclazosin	7B6W-α_1b-Cyclazosin
9.09	Single	7CKY	PW0464	7CKY-D₁-PW0464-Gs/&β;1/&γ;2
9.09	Single	7E2Z	Aripiprazole	7E2Z-5-HT_1A-Aripiprazole-Gi1/&β;1/&γ;2
9.09	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
9.09	Single	7EW7	PubChem 4077460	7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
9.09	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/&β;1/&γ;2
9.09	Single	7S8M	Cortistatin-14	7S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
9.09	Single	7T2H	Lofentanil	7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
9.09	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/&β;1/&γ;2
9.09	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
9.09	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
9.09	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
9.09	Single	7U2L	PubChem 163201242	7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
9.09	Single	7XOW	Gastrin	7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2
9.09	Single	7XOX	Cholecystokinin-8	7XOX-CCK_B-Cholecystokinin-8-Gq/&β;1/&γ;2
9.09	Single	7XWO	Neurokinin-A	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
9.09	Single	8DZP	momSalB	8DZP-κ-momSalB-Gi1/&β;1/&γ;2
9.09	Single	8E0G	BU72	8E0G-μ-BU72
9.09	Single	8FMZ	Neurotensin/neuromedin N	8FMZ-NTS₁-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
9.09	Single	8HDO	BAY 60-6583	8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2
9.09	Single	8HPT	C5a anaphylatoxin C-terminal peptide	8HPT-C5a₁-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
9.09	Single	8I9A	EP54	8I9A-C3a_B-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09	Single	8IRU	Rotigotine	8IRU-D₄-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
9.09	Single	8IUK	PGF2-alpha	8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09	Consensus	alpha1b_off	Orthosteric Ligand	7B6W-α_1b-Cyclazosin
9.09	Consensus	arrestin2	Orthosteric Ligand	6TKO-β₁-Arformoterol-Arrestin2 6PWC-NTS₁-Neurotensin-Arrestin2 7R0C-V₂-Acyclovir triphosphate-Arrestin2
9.09	Consensus	class-a_off	Orthosteric Ligand	sensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
9.09	Consensus	gs_compl-peptide	Orthosteric Ligand	8I9A-C3a_B-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09	Consensus	kop_off	Orthosteric Ligand	4DJH-κ-JDTic
9.09	Consensus	lpa1_on	Orthosteric Ligand	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
9.09	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
9.09	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
9.09	Consensus	s1p2_on	Orthosteric Ligand	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
9.09	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
8.82	Single	8FLU	Long-acting PTH	8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
8.70	Single	4N4W	SANT-1	4N4W-SMO-SANT-1
8.70	Single	4Z36	ONO-3080573	4Z36-LPA₁-ONO-3080573
8.70	Single	6A93	Risperidone	6A93-5-HT_2A-Risperidone
8.70	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
8.70	Single	6XBL	Cholesterol	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
8.70	Single	7SUS	PubChem 122701908	7SUS-Apelin-PubChem 122701908
8.70	Single	7T6B	S1P	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
8.70	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
8.70	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
8.70	Single	7WCN	AR231453	7WCN-GPR119-AR231453-Gs/&β;1/&γ;2
8.70	Single	7X1T	Taltirelin	7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.70	Single	7XZ5	Lysophosphatidylcholine	7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
8.70	Single	7YIT	Nalfurafine	7YIT-κ-Nalfurafine
8.70	Single	8IJD	MK6892	8IJD-HCA₂-MK6892-Gi1/&β;1/&γ;2
8.70	Single	8JJL	Olodaterol	8JJL-β₂-Olodaterol
8.70	Single	8JWY	PubChem 168451710	8JWY-A_2A-PubChem 168451710
8.70	Single	8JZ7	MK6892	8JZ7-HCA₂-MK6892-Gi1/&β;1/&γ;2
8.70	Consensus	d2_off	Orthosteric Ligand	6CM4-D₂-Risperidone 6LUQ-D₂-Haloperidol 7DFP-D₂-Spiperone
8.70	Consensus	gi_class-f	Other Ligand	gi_frizzled
8.70	Consensus	gi_frizzled	Other Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
8.70	Consensus	leuko_off	Orthosteric Ligand	blt_off cyslt_off
8.70	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z34-LPA₁-ONO-9780307 4Z35-LPA₁-ONO-9910539 7YU4-LPA₁-ONO-0740556
8.70	Consensus	nts1_on	Orthosteric Ligand	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
8.70	Consensus	nts_on	Orthosteric Ligand	nts1_on
8.70	Consensus	opioid_off	Orthosteric Ligand	kop_off mop_off nop_off dop_off
8.70	Consensus	peptide_off	Orthosteric Ligand	opioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
8.70	Consensus	prostanoid_on	Orthosteric Ligand	ep_on fpa_on
8.57	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
8.57	Single	8F0K	Pramlintide analogue san385	8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
8.57	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
8.33	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
8.33	Single	5TZY	MK8666; PubChem 127053597	5TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
8.33	Single	6DDF	Damgo	6DDF-μ-Damgo-Gi1/&β;1/&γ;2
8.33	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
8.33	Single	7QVM	Oxytocin	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
8.33	Single	7U2K	C6-guano	7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
8.33	Single	7WVV	fMLFII	7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
8.33	Single	7X2D	Tavapadon	7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2
8.33	Single	7XAV	Lanreotide	7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
8.33	Single	7XK2	MK6892	7XK2-HCA₂-MK6892-Gi1/&β;1/&γ;2
8.33	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
8.33	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
8.33	Single	8IQ6	Latanoprost	8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33	Consensus	cckb_on	Orthosteric Ligand	7XOW-CCK_B-Gastrin-Gq/&β;1/&γ;2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
8.33	Consensus	fpa_on	Orthosteric Ligand	8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33	Consensus	gi_class-a	Orthosteric Ligand	gi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
8.33	Consensus	nk2_on	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.33	Consensus	ot_on	Orthosteric Ligand	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
8.11	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
8.11	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
8.00	Single	6KNM	JN241-9	6KNM-Apelin-JN241-9
8.00	Single	6XBJ	Cholesterol	6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
8.00	Single	7MTR	ADX55164	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
8.00	Single	7NA7	Ghrelin-27	7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
8.00	Single	7X1U	TRH	7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.00	Single	7XN9	L-054,522	7XN9-SST2-L-054,522
8.00	Single	7XY6	PubChem 11717831	7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
8.00	Single	7YAE	Octreotide	7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
8.00	Single	8IA7	Cholecystokinin-8	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
8.00	Single	8IQ4	Carboprost	8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00	Single	8IUM	Tafluprost acid	8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00	Single	8X5Y	Astemizole	8X5Y-H₁-Astemizole
8.00	Consensus	go_vasopressin	Orthosteric Ligand	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
8.00	Consensus	protein_on	Orthosteric Ligand	ccr_on chemokine_on gphr_on chemerin_on
7.69	Single	4AMJ	(S)-Carvedilol	4AMJ-β₁-(S)-Carvedilol
7.69	Single	7WIC	Somatostatin-14	7WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
7.69	Single	7WKD	TRH	7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69	Single	7WVW	fMYFINILTL	7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
7.69	Single	8HS2	Fab046	8HS2-GPR20-Fab046
7.69	Single	8IZB	Lysophosphatidylserine	8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
7.69	Single	8XBH	S3E-LysoPS	8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
7.69	Consensus	go_class-a	Orthosteric Ligand	go_amine go_peptide go_protein
7.69	Consensus	gs_pth	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
7.50	Consensus	glu_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
7.41	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
7.41	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
7.41	Single	7DDZ	JNJ-31020028	7DDZ-Y₂-JNJ-31020028
7.41	Single	7WJ5	Somatostatin-14	7WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
7.41	Single	8F7W	Dynorphin	8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
7.41	Consensus	npy2_off	Orthosteric Ligand	7DDZ-Y₂-JNJ-31020028
7.41	Consensus	vasopressin-ot_on	Orthosteric Ligand	ot_on v2_on
7.32	Single	8F2B	Pramlintide analogue san45	8F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
7.14	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
7.14	Single	6PT2	KGCHM07	6PT2-δ-KGCHM07
7.14	Single	6VN7	PACAP	6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
6.90	Single	7DW9	Acyclovir triphosphate	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
6.90	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
6.90	Consensus	go_class-b	Orthosteric Ligand	go_class-b1 go_class-b2
6.90	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
6.67	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
6.67	Single	6VCB	LSN3160440	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
6.67	Single	7V68	PubChem 57664406	7V68-M₄-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
6.67	Single	7WC4	Serotonin	7WC4-5-HT_2A-Serotonin
6.67	Single	7XKE	Betahydroxyandrosterone	7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
6.67	Single	8HQM	NPGLY	8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
6.67	Single	8HSC	Fab046	8HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
6.67	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
6.45	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
6.45	Consensus	gs_vasopressin-ot	Orthosteric Ligand	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
6.45	Consensus	kop_on	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
6.25	Single	6OT0	25(S)-Epoxycholesterol	6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
6.25	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
6.25	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
6.25	Single	8U4Q	REGN7663-Fab	8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
6.25	Consensus	gs_cgrp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
6.06	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/&β;1/&γ;2
6.06	Single	8FLT	M-PTH(1-14)	8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
6.06	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
6.06	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2
6.06	Consensus	calcitonin_on	Orthosteric Ligand	ct_on ctlike_on
5.88	Single	2ZIY	11-cis-Retinal	2ZIY-Rhodopsin-11-cis-Retinal
5.88	Single	5WKT	Octyl Beta-D-Glucopyranoside	5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
5.88	Single	6LI0	GTPL9804	6LI0-GPR52-GTPL9804
5.88	Single	6ME5	Agomelatine	6ME5-MT₁-Agomelatine
5.88	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
5.88	Single	7V6A	PubChem 9864275	7V6A-M₄-PubChem 9864275-Gi1/&β;1/&γ;2
5.88	Single	7WC5	Psilocin	7WC5-5-HT_2A-Psilocin
5.88	Single	8J24	Acetic acid	8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
5.88	Single	8J6Q	Beta-hydroxybutyrate	8J6Q-HCA₂-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
5.88	Single	8JGB	Conorfamide-Tx2	8JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
5.71	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
5.56	Single	4O9R	Cyclopamine	4O9R-SMO-Cyclopamine
5.56	Single	5L7I	Vismodegib	5L7I-SMO-Vismodegib
5.56	Single	5TE5	20-Methanoretinal	5TE5-Rhodopsin-20-Methanoretinal
5.56	Single	6I9K	9-cis-Retinal	6I9K-Rhodopsin-9-cis-Retinal
5.56	Single	6TP4	ACT-462206	6TP4-OX₁-ACT-462206
5.56	Single	6TQ4	PubChem 16046844	6TQ4-OX₁-PubChem 16046844-Na
5.56	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.56	Single	7VUI	JNJ-63533054	7VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
5.56	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/&β;1/&γ;2
5.56	Single	8IY9	Niacin	8IY9-HCA₂-Niacin-Go/&β;1/&γ;2
5.56	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.56	Single	8U4R	REGN7663-Fab	8U4R-CXCR4-REGN7663-Fab-Cholesterol
5.56	Single	8X2K	5YM	8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
5.56	Consensus	mt2_on	Orthosteric Ligand	7VH0-MT₂-Ramelteon-Gi1/&β;1/&γ;1
5.56	Consensus	ox1_off_allo	Orthosteric Ligand	6TOD-OX₁-EMPA-Na 6TOS-OX₁-GSK1059865-Na 6TQ4-OX₁-PubChem 16046844-Na 6TO7-OX₁-Suvorexant-Na
5.56	Consensus	smo_on_allo	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.26	Single	2X72	All-trans-retinal	2X72-Rhodopsin-All-trans-retinal-Gt(CT)
5.26	Single	2Z73	11-cis-Retinal	2Z73-Rhodopsin-11-cis-Retinal
5.26	Single	3AYN	9-cis-Retinal	3AYN-Rhodopsin-9-cis-Retinal
5.26	Single	3PWH	ZM241385	3PWH-A_2A-ZM241385
5.26	Single	4QIN	SAG1.5	4QIN-SMO-SAG1.5
5.26	Single	6NWE	Octyl Beta-D-Glucopyranoside	6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
5.26	Single	6O3C	SAG21k	6O3C-SMO-SAG21k-Cholesterol
5.26	Single	6TOD	EMPA	6TOD-OX₁-EMPA-Na
5.26	Single	6TQ6	PubChem 145714283	6TQ6-OX₁-PubChem 145714283
5.26	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
5.26	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.26	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
5.26	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
5.26	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.26	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.26	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.26	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.26	Single	7W0M	PubChem 122701908	7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
5.26	Single	8FN0	Neurotensin/neuromedin N	8FN0-NTS₁-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
5.26	Single	8GNG	Istradefylline	8GNG-A_2A-Istradefylline
5.26	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.26	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
5.26	Consensus	class-f_off	Orthosteric Ligand	smo_off
5.26	Consensus	cxcr1_on	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
5.26	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
5.26	Consensus	smo_on_allo	Other Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.00	Single	3REY	PubChem 5697	3REY-A_2A-PubChem 5697
5.00	Single	5TE3	Octyl Beta-D-Glucopyranoside	5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
5.00	Single	6DS0	Ly266097	6DS0-5-HT_2B-Ly266097
5.00	Single	6ME3	2-Phenylmelatonin	6ME3-MT₁-2-Phenylmelatonin
5.00	Single	6ME4	2-Iodomelatonin	6ME4-MT₁-2-Iodomelatonin
5.00	Single	6MH8	ZM241385	6MH8-A_2A-ZM241385
5.00	Single	6TPK	Retosiban	6TPK-OT-Retosiban
5.00	Single	6TPN	HTL6641	6TPN-OX₂-HTL6641
5.00	Single	6XBL	SAG	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.00	Single	6ZIN	SR48692	6ZIN-NTS₁-SR48692
5.00	Single	7BB6	Acyclovir triphosphate	7BB6-V₂-Acyclovir triphosphate-Gs/&β;1/&γ;2
5.00	Single	7JOZ	VFP	7JOZ-D₁-VFP-Gs/&β;1/&γ;2
5.00	Single	7UTZ	PubChem 644078	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
5.00	Single	7VOD	Cariprazine	7VOD-5-HT_2A-Cariprazine
5.00	Single	7VUG	JNJ-63533054	7VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
5.00	Single	7VVO	PTH	7VVO-PTH1-PTH-Gs/&β;1/&γ;2
5.00	Single	7WC9	PubChem 162421364	7WC9-5-HT_2A-PubChem 162421364
5.00	Single	7WVU	fMLF	7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
5.00	Single	7ZI0	SAG	7ZI0-SMO-SAG-Cholesterol
5.00	Single	8HJ5	PubChem 139030531	8HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00	Single	8K4N	VF0	8K4N-GPR34-VF0-Gi1/&β;1/&γ;2
5.00	Single	8T3V	DHA	8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00	Consensus	5ht2a_off	Orthosteric Ligand	6A94-5-HT_2A-Zotepine 6WH4-5-HT_2A-Methiothepin 7VOE-5-HT_2A-Aripiprazole 7VOD-5-HT_2A-Cariprazine 7WC8-5-HT_2A-Lumateperone 6A93-5-HT_2A-Risperidone
5.00	Consensus	cxcr2_on	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
5.00	Consensus	cxcr_on	Orthosteric Ligand	cxcr1_on cxcr2_on
5.00	Consensus	ffa2_on	Orthosteric Ligand	8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
5.00	Consensus	gi_class-f	Orthosteric Ligand	gi_frizzled
5.00	Consensus	gi_frizzled	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.00	Consensus	gnrh_off	Orthosteric Ligand	gnrh1_off
5.00	Consensus	lh_on_allo	Other Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Consensus	ot_off	Orthosteric Ligand	6TPK-OT-Retosiban
5.00	Consensus	vasopressin-ot_off	Orthosteric Ligand	ot_off
4.76	Single	2Y02	Carmoterol	2Y02-β₁-Carmoterol
4.76	Single	2Y04	Salbutamol	2Y04-β₁-Salbutamol
4.76	Single	4J4Q	Octyl Beta-D-Glucopyranoside	4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
4.76	Single	4QKX	PubChem 76210628	4QKX-β₂-PubChem 76210628
4.76	Single	5OLZ	PubChem 135566609	5OLZ-A_2A-PubChem 135566609-Na
4.76	Single	5OM1	PubChem 135566609	5OM1-A_2A-PubChem 135566609-Na
4.76	Single	6DRZ	Methysergide	6DRZ-5-HT_2B-Methysergide
4.76	Single	6PS8	2-Phenylmelatonin	6PS8-MT₁-2-Phenylmelatonin
4.76	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
4.76	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
4.76	Single	7SK8	CXCL12	7SK8-ACKR3-CXCL12-CCX662
4.76	Single	7VGZ	Remalteon	7VGZ-MT₁-Remalteon-Gi1/&β;1/&γ;2
4.76	Single	7VH0	Ramelteon	7VH0-MT₂-Ramelteon-Gi1/&β;1/&γ;1
4.76	Single	7WC8	Lumateperone	7WC8-5-HT_2A-Lumateperone
4.76	Single	7XJH	Isoproterenol	7XJH-β₃-Isoproterenol-Gs/&β;1/&γ;2
4.76	Single	8CIC	Etrumadenant	8CIC-A_2A-Etrumadenant-Na
4.76	Single	8CU6	LJ-4517	8CU6-A_2A-LJ-4517
4.76	Single	8DZS	GR89,696	8DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
4.76	Single	8IC0	Interleukin-8	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
4.76	Single	8ID4	Linoleic acid	8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
4.76	Single	8IRT	Rotigotine	8IRT-D₃-Rotigotine-Gi1/&β;1/&γ;2
4.76	Single	8JGG	BAM8-22	8JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
4.76	Single	8JT8	(R)-IHCH-7179	8JT8-5-HT_2A-(R)-IHCH-7179
4.76	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
4.76	Single	8X17	Namodenoson	8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
4.76	Consensus	5ht1a_on	Orthosteric Ligand	8JSP-5-HT_1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT_1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT_1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT_1A-Serotonin-Gi1/&β;1/&γ;2
4.76	Consensus	5ht2_off	Orthosteric Ligand	5ht2a_off 5ht2b_off 5ht2c_off
4.76	Consensus	alpha_off	Orthosteric Ligand	alpha1_off alpha2_off
4.76	Consensus	ffa1_on	Orthosteric Ligand	8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.76	Consensus	fsh_on_allo	Other Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
4.76	Consensus	gs_calcitonin	Orthosteric Ligand	gs_ct gs_cgrp
4.76	Consensus	smo_off	Orthosteric Ligand	5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
4.55	Single	2Y00	Dobutamine	2Y00-β₁-Dobutamine
4.55	Single	2Y03	Isoprenaline	2Y03-β₁-Isoprenaline
4.55	Single	4PHU	Fasiglifam	4PHU-FFA1 (GPR40)-Fasiglifam
4.55	Single	5C1M	BU72	5C1M-μ-BU72
4.55	Single	5N2S	PSB36	5N2S-A₁-PSB36
4.55	Single	5OM4	PubChem 135566609	5OM4-A_2A-PubChem 135566609-Na
4.55	Single	5XPR	Bosentan	5XPR-ET_B-Bosentan
4.55	Single	6LFM	Interleukin-8	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
4.55	Single	6LUQ	Haloperidol	6LUQ-D₂-Haloperidol
4.55	Single	6ME7	2-Phenylmelatonin	6ME7-MT₂-2-Phenylmelatonin
4.55	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
4.55	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
4.55	Single	6Z4S	SR48692	6Z4S-NTS₁-SR48692
4.55	Single	7BZ2	Arformoterol	7BZ2-β₂-Arformoterol-Gs/&β;1/&γ;2
4.55	Single	7CKX	A77636	7CKX-D₁-A77636-Gs/&β;1/&γ;2
4.55	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
4.55	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
4.55	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
4.55	Single	7T9N	PubChem 644078	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
4.55	Single	7VOE	Aripiprazole	7VOE-5-HT_2A-Aripiprazole
4.55	Single	7VUH	JNJ-63533054	7VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
4.55	Single	7VV0	PAMP-12	7VV0-MRGPRX2-PAMP-12
4.55	Single	7WIG	L-054,264	7WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
4.55	Single	7Y26	Octreotide	7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55	Single	7Y27	Somatostatin-14	7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55	Single	8C9W	Etrumadenant	8C9W-A_2A-Etrumadenant
4.55	Single	8GNE	KW-6356	8GNE-A_2A-KW-6356-Na
4.55	Single	8ID9	Eicosapentaenoic acid	8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
4.55	Single	8IZ4	Lysophosphatidylserine	8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
4.55	Single	8J19	PubChem 127045422	8J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
4.55	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
4.55	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
4.55	Consensus	5ht2b_off	Orthosteric Ligand	6DRZ-5-HT_2B-Methysergide 6DRX-5-HT_2B-Lisuride
4.55	Consensus	d1_on	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2 7CKY-D₁-PW0464-Gs/&β;1/&γ;2 8IRR-D₁-Rotigotine-Gs/&β;1/&γ;2 7JV5-D₁-SKF81297-Gs/&β;1/&γ;2 7JVP-D₁-SKF83959-Gs/&β;1/&γ;2 7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D₁-VFP-Gs/&β;1/&γ;2 7CKX-D₁-A77636-Gs/&β;1/&γ;2 7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2
4.55	Consensus	d2_on	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2
4.55	Consensus	gs_sst	Orthosteric Ligand	7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35	Single	3PDS	Hydroxybenzylisoproterenol	3PDS-β₂-Hydroxybenzylisoproterenol
4.35	Single	3SN6	BI167107	3SN6-β₂-BI167107-Gs/&β;1/&γ;2
4.35	Single	4IAQ	Dihydroergotamine	4IAQ-5-HT_1B-Dihydroergotamine
4.35	Single	6E59	L-760735	6E59-NK₁-L-760735
4.35	Single	6GT3	Imaradenant	6GT3-A_2A-Imaradenant-Na
4.35	Single	6H7J	Isoprenaline	6H7J-β₁-Isoprenaline
4.35	Single	6J20	Aprepitant	6J20-NK₁-Aprepitant
4.35	Single	6N48	BI167107	6N48-β₂-BI167107-PubChem 138454256
4.35	Single	6NI3	BI167107	6NI3-β₂-BI167107-Gs/&β;1/&γ;2
4.35	Single	6WGT	LSD	6WGT-5-HT_2A-LSD
4.35	Single	6Z4Q	SR142948A	6Z4Q-NTS₁-SR142948A
4.35	Single	7F1T	MIP-1a	7F1T-CCR5-MIP-1a
4.35	Single	7JJO	Isoprenaline	7JJO-β₁-Isoprenaline-Gs/&β;1/&γ;2
4.35	Single	7JV5	SKF81297	7JV5-D₁-SKF81297-Gs/&β;1/&γ;2
4.35	Single	7JVP	SKF83959	7JVP-D₁-SKF83959-Gs/&β;1/&γ;2
4.35	Single	7PX4	PSB-2113	7PX4-A_2A-PSB-2113
4.35	Single	7SK7	CXCL12	7SK7-ACKR3-CXCL12-CCX662
4.35	Single	7W41	PD176252	7W41-BB₂-PD176252
4.35	Single	7WVX	Humanin	7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
4.35	Single	8G05	6-OAU	8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
4.35	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
4.35	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.35	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
4.35	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35	Single	8X79	MRE-269	8X79-I2-MRE-269-Gs/&β;1/&γ;2
4.35	Single	8XBI	S3E-LysoPS	8XBI-GPR34-S3E-LysoPS
4.35	Single	8XJM	Latanoprost	8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
4.35	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
4.35	Consensus	5ht5_off	Orthosteric Ligand	5ht5a_off
4.35	Consensus	a2b_on	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Consensus	bb2_off	Orthosteric Ligand	7W41-BB₂-PD176252
4.35	Consensus	bombesin_off	Orthosteric Ligand	bb2_off
4.35	Consensus	dopamine_off	Orthosteric Ligand	d3_off d2_off d4_off
4.35	Consensus	ffa4_on	Orthosteric Ligand	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Consensus	gi_dopamine	Orthosteric Ligand	8IRT-D₃-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D₃-PD128907-Gi1/&β;1/&γ;2 7CMU-D₃-Pramipexole-Gi1/&β;1/&γ;2
4.35	Consensus	gi_ffa	Orthosteric Ligand	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
4.35	Consensus	gi_muscarinic	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M₄-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M₄-PubChem 9864275-Gi1/&β;1/&γ;2
4.35	Consensus	gs_adenosine	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A_2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A_2A-NECA-Gs/&β;1/&γ;1 7XY7-A_2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A_2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
4.35	Consensus	gs_dopamine	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/&β;1/&γ;2 7CKX-D₁-A77636-Gs/&β;1/&γ;2 7JVQ-D₁-Apomorphine-Gs/&β;1/&γ;2 7CKY-D₁-PW0464-Gs/&β;1/&γ;2 8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D₁-SKF81297-Gs/&β;1/&γ;2 7JVP-D₁-SKF83959-Gs/&β;1/&γ;2 7X2D-D₁-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D₁-VFP-Gs/&β;1/&γ;2
4.35	Consensus	gs_nucleotide	Orthosteric Ligand	gs_adenosine
4.35	Consensus	npy_off	Orthosteric Ligand	npy2_off npy1_off
4.17	Single	3VW7	Vorapaxar; Na	3VW7-PAR1-Vorapaxar; Na
4.17	Single	4AMI	Bucindolol	4AMI-β₁-Bucindolol
4.17	Single	4LDE	BI167107	4LDE-β₂-BI167107
4.17	Single	4PY0	2MeSATP	4PY0-P2Y₁₂-2MeSATP
4.17	Single	5F8U	Cyanopindolol	5F8U-β₁-Cyanopindolol
4.17	Single	6DRY	Methylergonovine	6DRY-5-HT_2B-Methylergonovine
4.17	Single	6HLP	Netupitant	6HLP-NK₁-Netupitant
4.17	Single	6ME6	2-Phenylmelatonin	6ME6-MT₂-2-Phenylmelatonin
4.17	Single	6MXT	Salmeterol	6MXT-β₂-Salmeterol
4.17	Single	6TKO	Arformoterol	6TKO-β₁-Arformoterol-Arrestin2
4.17	Single	6VMS	Bromoergocryptine	6VMS-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2
4.17	Single	7DH5	Mirabegron	7DH5-β₃-Mirabegron-Gs/&β;1/&γ;2
4.17	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/&β;1/&γ;2
4.17	Single	7L0S	Neurotensin	7L0S-NTS₁-Neurotensin-Gi1/&β;1/γ1
4.17	Single	7L1U	Orexin	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17	Single	7WCM	MBX-2982	7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
4.17	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
4.17	Single	7XW6	ML109	7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
4.17	Single	7XW9	TRH	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
4.17	Single	7XXI	2MeSADP	7XXI-P2Y₁₂-2MeSADP-Gi2/&β;1/&γ;2
4.17	Single	7Y24	Octreotide	7Y24-SST2-Octreotide-Go/&β;1/&γ;2
4.17	Single	8DWC	Proenkephalin-A	8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17	Single	8IRS	Rotigotine	8IRS-D₂-Rotigotine-Gi1/&β;1/&γ;2
4.17	Single	8IRV	Rotigotine	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
4.17	Single	8JGF	BAM8-22	8JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17	Single	8WRB	Lysophosphatidylserine	8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
4.17	Consensus	beta1_on	Orthosteric Ligand	7JJO-β₁-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β₁-Dobutamine-Gs/&β;1/&γ;2
4.17	Consensus	gs_trh	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
4.17	Consensus	m4_on	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M₄-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M₄-PubChem 9864275-Gi1/&β;1/&γ;2
4.17	Consensus	nts1_off	Orthosteric Ligand	6Z4Q-NTS₁-SR142948A 6Z4S-NTS₁-SR48692
4.17	Consensus	nts_off	Orthosteric Ligand	nts1_off
4.17	Consensus	trh_on	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
4.17	Consensus	tsh_on_allo	Other Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
4.00	Single	4NC3	Ergotamine	4NC3-5-HT_2B-Ergotamine
4.00	Single	4PXZ	2MeSADP	4PXZ-P2Y₁₂-2MeSADP
4.00	Single	5TUD	Ergotamine	5TUD-5-HT_2B-Ergotamine
4.00	Single	6BQG	Ergotamine	6BQG-5-HT_2C-Ergotamine
4.00	Single	6BQH	Ritanserin	6BQH-5-HT_2C-Ritanserin
4.00	Single	6H7L	Dobutamine	6H7L-β₁-Dobutamine
4.00	Single	6IBL	Arformoterol	6IBL-β₁-Arformoterol
4.00	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2
4.00	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2
4.00	Single	7EZC	UKA	7EZC-A_2A-UKA
4.00	Single	7JVR	Bromoergocryptine	7JVR-D₂-Bromoergocryptine-Gi1/&β;1/&γ;2
4.00	Single	7MTS	ADX55164	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
4.00	Single	7UM4	AS2674723	7UM4-5-HT_5A-AS2674723
4.00	Single	8T3O	TUG-891	8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.00	Consensus	5ht2c_off	Orthosteric Ligand	6BQH-5-HT_2C-Ritanserin
4.00	Consensus	5ht5a_off	Orthosteric Ligand	7UM4-5-HT_5A-AS2674723
4.00	Consensus	class-a_on	Orthosteric Ligand	sensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
4.00	Consensus	ffa4_on_allo	Orthosteric Ligand	8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.85	Single	4UG2	CGS21680	4UG2-A_2A-CGS21680
3.85	Single	5WF6	UK-432097	5WF6-A_2A-UK-432097
3.85	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
3.70	Single	4IAR	Ergotamine	4IAR-5-HT_1B-Ergotamine
3.70	Single	6RZ8	ONO-2080365	6RZ8-CysLT₂-ONO-2080365
3.70	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
3.70	Single	8G59	TUG-891	8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
3.70	Consensus	mop_off	Orthosteric Ligand	7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
3.57	Single	3QAK	UK-432097	3QAK-A_2A-UK-432097
3.57	Single	4IB4	Ergotamine	4IB4-5-HT_2B-Ergotamine
3.57	Single	8DWG	Proenkephalin-A	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.45	Single	5WF5	UK-432097	5WF5-A_2A-UK-432097
3.45	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/&β;1/&γ;2
3.45	Consensus	gs_class-a	Orthosteric Ligand	gs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
3.33	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
3.33	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
3.12	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
2.94	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/&β;1/&γ;2

PDB Summary
PDB	6ORV
Class	B1
SubFamily	Peptide
Type	Glucagon
SubType	GLP-1
Species	Homo sapiens
Ligand	-
Other Ligand(s)	TT-OAD2
Protein Partners	Gs/Beta1/Gamma2
PDB Resolution	3
Date	2020-01-08
D.O.I.	10.1038/s41586-019-1902-z

Net Summary
I_min	3.5
Number of Linked Nodes	835
Number of Links	1016
Number of Hubs	165
Number of Links mediated by Hubs	613
Number of Communities	26
Number of Nodes involved in Communities	237
Number of Links involved in Communities	348

Path Summary
Number Of Nodes in MetaPath	111
Number Of Links MetaPath	110
Number of Shortest Paths	1774815
Length Of Smallest Path	3
Average Path Length	34.7093
Length of Longest Path	65
Minimum Path Strength	1.16
Average Path Strength	7.26233
Maximum Path Strength	25.725
Minimum Path Correlation	0.7
Average Path Correlation	0.982267
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.22222
Average % Of Corr. Nodes	40.3374
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	53.7635
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	N2V
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	N2V
Name	N-{(3S,8S)-3-{4-[(3,4-dichlorophenyl)methoxy]phenyl}-7-[(1S)-1-phenylpropyl]-2,3,6,7,8,9-hexahydro[1,4]dioxino[2,3-g]isoquinoline-8-carbonyl}-4-(2,3-dimethylpyridin-4-yl)-L-phenylalanine
Synonyms
Identifier	(2~{S})-2-[[(3~{S},8~{S})-3-[4-[(3,4-dichlorophenyl)methoxy]phenyl]-7-[(1~{S})-1-phenylpropyl]-3,6,8,9-tetrahydro-2~{H}-[1,4]dioxino[2,3-g]isoquinolin-8-yl]carbonylamino]-3-[4-(2,3-dimethylpyridin-4-yl)phenyl]propanoic acid
Formula	C50 H47 Cl2 N3 O6
Molecular Weight	856.831
SMILES	CC[C@@H](c1ccccc1)N2Cc3cc4c(cc3C[C@H]2C(=O)N[C@@H](Cc5ccc(cc5)c6ccnc(c6C)C)C(=O)O)OC[C@@H](O4)c7ccc(cc7)OCc8ccc(c(c8)Cl)Cl
PubChem	58327143
Formal Charge	0
Total Atoms	108
Total Chiral Atoms	4
Total Bonds	115
Total Aromatic Bonds	36


PDBsum	Open PDBsum Page
Chain	A
Protein	G Protein α Sub unit
UniProt	P63092
Sequence	>6ORV_Chain_A D Q R N E E K A Q R E A N K K I E K Q L Q K D K Q V Y R A T H R L L L L G S G I F E T K F Q V D K V N F H M F D V G A Q R D E R R K W I Q C F N D V T A I I F V V A N R L Q A A L K L F D S I W N N K W L R D T S V I L F L N K Q D I E D Y F P E F A R Y T T P E D A T P E P G E D P R V T R A K Y F I R D E F L R I S T A S G D G R H Y C Y P H F T N I R R V F N D C R D I I Q R M H L R Q Y E L L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	B
Protein	G Protein β Sub unit
UniProt	P62873
Sequence	>6ORV_Chain_B E L D Q L R Q E A E Q L K N Q I R D A R K A C A D A T L S Q I T N N I D P V G R I Q M R T R R T L R G H L A K I Y A M H W G T D S R L L V S A S Q D G K L I I W D S Y T T N K V H A I P L R S S W V M T C A Y A P S G N Y V A C G G L D N I C S I Y N L K T R E G N V R V S R E L A G H T G Y L S C C R F L D D N Q I V T S S G D T T C A L W D I E T G Q Q T T T F T G H T G D V M S L S L A P D T R L F V S G A C D A S A K L W D V R E G M C R Q T F T G H E S D I N A I C F F P N G N A F A T G S D D A T C R L F D L R A D Q E L M T Y S H D N I I C G I T S V S F S K S G R L L L A G Y D D F N C N V W D A L K A D R A G V L A G H D N R V S C L G V T D D G M A V A T G S W D S F L K I W N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	G
Protein	G Protein γ Sub unit
UniProt	P59768
Sequence	>6ORV_Chain_G T A S I A Q A R K L V E Q L K M E A N I D R I K V S K A A A D L M A Y C E A H A K E D P L L T P V P A S E N P F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P43220
Sequence	>6ORV_Chain_R P E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F R H L H C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S T A A Q Q H Q W D G L L S Y Q D S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S V F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E D E G C W T R N S N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A D I K C R L A K S T L T L I P L L G T H E V I F A F V M D E H A R G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E V Q L E F R K S W E R W R L E Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5NX2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	-	3.7	2017-06-14	10.1038/nature22800
	5VAI	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-	Gs/&β;1/&γ;2	4.1	2017-05-24	10.1038/nature22394
	5VEW	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.7	2017-05-24	10.1038/nature22378
	5VEX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	NNC0640	-	3	2017-05-17	10.1038/nature22378
	6B3J	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-	Gs/&β;1/&γ;2	3.3	2018-02-21	10.1038/nature25773
	6KJV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	2.8	2019-11-13	10.1107/S2052252519013496
	6KK1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	2.8	2019-11-13	10.1107/S2052252519013496
	6KK7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	3.1	2019-11-13	10.1107/S2052252519013496
	6LN2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	3.2	2020-03-18	10.1038/s41467-020-14934-5
	6ORV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2	Gs/&β;1/&γ;2	3	2020-01-08	10.1038/s41586-019-1902-z
	6VCB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440	Gs/&β;1/&γ;2	3.3	2020-07-22	10.1038/s41589-020-0589-7
	6X18	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-	Gs/&β;1/&γ;2	2.1	2020-09-09	10.1016/j.molcel.2020.09.020
	6X19	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-	Gs/&β;1/&γ;2	2.1	2020-09-09	10.1016/j.molcel.2020.09.020
	6X1A	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/&β;1/&γ;2	2.5	2020-09-09	10.1016/j.molcel.2020.09.020
	6XOX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-	chim(NtGi1-Gs)/&β;1/&γ;2	3.1	2020-11-18	10.1073/pnas.2014879117
	7C2E	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-	Gs/&β;1/&γ;2	4.2	2020-08-26	10.1038/s41422-020-0384-8
	7DUQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738	Gs/&β;1/&γ;2	2.5	2021-07-14	10.1038/s41467-021-24058-z
	7DUR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/&β;1/&γ;2	3.3	2021-08-11	10.1038/s41467-021-24058-z
	7E14	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738	Gs/&β;1/&γ;2	2.9	2021-07-07	10.1038/s41467-021-24058-z
	7EVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/&β;1/&γ;2	2.5	2021-08-11	10.1038/s41467-021-24058-z
	7FIM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	Gs/&β;1/&γ;2	3.4	2022-03-02	10.1038/s41467-022-28683-0
	7KI0	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-	Gs/&β;1/&γ;2	2.5	2021-08-04	10.1016/j.celrep.2021.109374
	7KI1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-	Gs/&β;1/&γ;2	2.5	2021-08-04	10.1016/j.celrep.2021.109374
	7LCI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/&β;1/&γ;2	2.9	2021-01-20	10.1016/j.str.2021.04.008
	7LCJ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	2.82	2021-01-20	10.1016/j.str.2021.04.008
	7LCK	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	3.24	2021-01-20	10.1016/j.str.2021.04.008
	7LLL	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/&β;1/&γ;2	3.7	2022-01-12	10.1038/s41467-021-27760-0
	7LLY	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-	Gs/&β;1/&γ;2	3.3	2022-01-12	10.1038/s41467-021-27760-0
	7RG9	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	chim(NtGi1-Gs)/&β;1/&γ;2	3.2	2022-04-13	10.1073/pnas.2116506119
	7RGP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	chim(NtGi1-Gs)/&β;1/&γ;2	2.9	2022-04-13	10.1073/pnas.2116506119
	7RTB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-	Gs/&β;1/&γ;2	2.14	2021-10-06	10.1016/j.bbrc.2021.09.016
	7S15	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 134611223	-	-	3.8	2022-06-08	10.1021/acs.jmedchem.1c01856
	7S1M	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-	Gs/&β;1/&γ;2	2.41	2022-01-05	10.1038/s41589-021-00945-w
	7S3I	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/&β;1/&γ;2	2.51	2022-01-05	10.1038/s41589-021-00945-w
	7VBH	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-	Gs/&β;1/&γ;2	3	2022-04-06	10.1038/s41467-022-28683-0
	7VBI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-	Gs/&β;1/&γ;2	3	2022-03-02	10.1038/s41467-022-28683-0
	7X8R	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-	Gs/&β;1/&γ;2	2.61	2022-06-29	10.1073/pnas.2200155119
	7X8S	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-	Gs/&β;1/&γ;2	3.09	2022-06-29	10.1073/pnas.2200155119
	8JIP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-	chim(NtGi1-Gs)/&β;1/&γ;2	2.85	2023-09-06	10.1073/pnas.2303696120
	8JIR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-	chim(NtGi1-Gs)/&β;1/&γ;2	2.57	2023-09-06	10.1073/pnas.2303696120
	8JIS	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-	chim(NtGi1-Gs)/&β;1/&γ;2	2.46	2023-11-08	10.1073/pnas.2303696120
	8WG7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/&β;1/&γ;2	2.54	2024-03-06	10.1038/s41421-024-00649-0

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