psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:G10	L:L:H7	3.18	No	Yes	0	0	0
2	L:L:H7	R:R:Q234	7.42	Yes	Yes	0	0	7
3	L:L:H7	R:R:V237	6.92	Yes	No	0	0	6
4	L:L:H7	R:R:W306	3.17	Yes	No	0	0	6
5	L:L:A8	R:R:E387	6.03	No	No	0	0	8
6	L:L:E9	R:R:Y152	4.49	Yes	Yes	2	0	7
7	L:L:E9	R:R:R190	8.14	Yes	Yes	2	0	8
8	L:L:E9	R:R:L388	3.98	Yes	No	0	0	7
9	L:L:E9	R:R:T391	5.64	Yes	Yes	2	0	6
10	L:L:T11	R:R:D372	5.78	No	No	0	0	5
11	L:L:F12	L:L:V16	5.24	Yes	No	0	0	0
12	L:L:F12	R:R:L141	6.09	Yes	No	0	0	5
13	L:L:F12	R:R:L144	3.65	Yes	No	0	0	6
14	L:L:F12	R:R:Y148	5.16	Yes	No	0	0	7
15	L:L:T13	R:R:K197	9.01	No	Yes	0	0	6
16	L:L:D15	L:L:S14	2.94	No	No	0	0	0
17	L:L:S14	R:R:N300	2.98	No	No	0	0	6
18	L:L:D15	R:R:R380	4.76	No	Yes	0	0	5
19	L:L:L20	L:L:V16	2.98	No	No	0	0	0
20	L:L:?18	L:L:S17	6.54	No	No	0	0	0
21	L:L:S17	R:R:T298	6.4	No	No	0	0	5
22	L:L:L20	L:L:Y19	3.52	No	No	0	0	0
23	L:L:Y19	R:R:E138	17.96	No	No	0	0	2
24	L:L:L20	R:R:Y205	16.41	No	Yes	0	0	3
25	L:L:E21	R:R:S31	10.06	No	Yes	5	0	4
26	L:L:E21	R:R:Y205	6.73	No	Yes	0	0	3
27	L:L:E21	R:R:R299	8.14	No	No	5	0	4
28	L:L:A24	R:R:Y205	2.67	No	Yes	0	0	3
29	L:L:K26	R:R:E128	10.8	No	No	0	0	3
30	L:L:F28	L:L:I29	3.77	Yes	Yes	1	0	0
31	L:L:F28	L:L:W31	3.01	Yes	No	1	0	0
32	L:L:F28	L:L:L32	12.18	Yes	No	1	0	0
33	L:L:F28	R:R:T35	2.59	Yes	No	1	0	5
34	L:L:F28	R:R:V36	7.87	Yes	No	0	0	2
35	L:L:F28	R:R:W214	15.03	Yes	Yes	1	0	1
36	L:L:I29	R:R:T35	3.04	Yes	No	1	0	5
37	L:L:I29	R:R:L89	2.85	Yes	Yes	1	0	5
38	L:L:I29	R:R:P90	5.08	Yes	Yes	1	0	4
39	L:L:I29	R:R:W91	7.05	Yes	Yes	1	0	4
40	L:L:L32	L:L:W31	3.42	No	No	1	0	0
41	L:L:W31	R:R:W214	21.56	No	Yes	1	0	1
42	L:L:L32	R:R:W39	22.78	No	Yes	0	0	5
43	L:L:V33	R:R:Y69	5.05	No	Yes	1	0	6
44	L:L:V33	R:R:L123	4.47	No	No	1	0	5
45	R:R:T35	R:R:V30	3.17	No	No	0	5	2
46	R:R:P90	R:R:V30	3.53	Yes	No	0	4	2
47	R:R:S31	R:R:W33	6.18	Yes	No	5	4	3
48	R:R:E34	R:R:S31	10.06	No	Yes	5	4	4
49	R:R:R299	R:R:S31	5.27	No	Yes	5	4	4
50	R:R:L32	R:R:Q213	2.66	No	Yes	0	4	4
51	R:R:E34	R:R:W33	7.63	No	No	5	4	3
52	R:R:E34	R:R:K38	2.7	No	No	0	4	4
53	R:R:E41	R:R:Q37	11.47	No	No	0	4	4
54	R:R:E68	R:R:W39	3.27	No	Yes	0	4	5
55	R:R:W39	R:R:Y88	13.5	Yes	Yes	0	5	5
56	R:R:R40	R:R:R43	11.73	No	No	0	2	4
57	R:R:Q45	R:R:Y42	6.76	No	Yes	0	5	6
58	R:R:P86	R:R:Y42	2.78	Yes	Yes	1	8	6
59	R:R:W87	R:R:Y42	9.65	No	Yes	1	3	6
60	R:R:Y42	R:R:Y88	16.88	Yes	Yes	1	6	5
61	R:R:R43	R:R:R44	3.2	No	No	0	4	3
62	R:R:Q45	R:R:S49	5.78	No	No	0	5	2
63	R:R:C46	R:R:F66	8.38	No	Yes	8	8	7
64	R:R:C46	R:R:C71	7.28	No	No	8	8	9
65	R:R:Q47	R:R:T51	2.83	No	No	0	3	4
66	R:R:D53	R:R:S49	2.94	No	No	0	3	2
67	R:R:L50	R:R:T51	2.95	No	No	0	4	4
68	R:R:L50	R:R:R64	6.07	No	No	0	4	4
69	R:R:P56	R:R:T58	3.5	Yes	No	3	1	1
70	R:R:F61	R:R:P56	26.01	Yes	Yes	3	3	1
71	R:R:D74	R:R:P56	19.32	No	Yes	3	3	1
72	R:R:F61	R:R:T58	11.67	Yes	No	3	3	1
73	R:R:P77	R:R:T58	5.25	No	No	3	4	1
74	R:R:D74	R:R:F61	9.55	No	Yes	3	3	3
75	R:R:F61	R:R:G75	6.02	Yes	No	3	3	7
76	R:R:E76	R:R:F61	10.49	No	Yes	0	1	3
77	R:R:F61	R:R:P77	4.33	Yes	No	3	3	4
78	R:R:C104	R:R:C62	7.28	No	Yes	3	9	9
79	R:R:C62	R:R:W110	5.22	Yes	Yes	0	9	9
80	R:R:D67	R:R:T65	2.89	No	No	0	9	5
81	R:R:T65	R:R:W110	10.92	No	Yes	0	5	9
82	R:R:C71	R:R:F66	4.19	No	Yes	8	9	7
83	R:R:P86	R:R:Y69	6.95	Yes	Yes	1	8	6
84	R:R:L89	R:R:Y69	4.69	Yes	Yes	1	5	6
85	R:R:V100	R:R:Y69	5.05	No	Yes	0	7	6
86	R:R:R121	R:R:Y69	3.09	No	Yes	1	6	6
87	R:R:L123	R:R:Y69	10.55	No	Yes	1	5	6
88	R:R:C126	R:R:Y69	4.03	No	Yes	0	9	6
89	R:R:V81	R:R:W72	7.36	No	Yes	0	6	9
90	R:R:V83	R:R:W72	8.58	No	Yes	0	5	9
91	R:R:V100	R:R:W72	6.13	No	Yes	0	7	9
92	R:R:R102	R:R:W72	18.99	No	Yes	0	8	9
93	R:R:E76	R:R:S79	2.87	No	No	0	1	5
94	R:R:F103	R:R:F80	34.29	No	No	9	4	4
95	R:R:F80	R:R:W120	4.01	No	No	9	4	5
96	R:R:N82	R:R:Y101	8.14	No	No	0	4	5
97	R:R:C85	R:R:P86	3.77	No	Yes	0	9	8
98	R:R:C126	R:R:C85	5.46	No	No	0	9	9
99	R:R:P86	R:R:Y88	6.95	Yes	Yes	1	8	5
100	R:R:L89	R:R:P86	9.85	Yes	Yes	1	5	8
101	R:R:W87	R:R:Y88	3.86	No	Yes	1	3	5
102	R:R:L89	R:R:Y88	4.69	Yes	Yes	1	5	5
103	R:R:L89	R:R:W91	10.25	Yes	Yes	1	5	4
104	R:R:P90	R:R:W91	6.76	Yes	Yes	1	4	4
105	R:R:E128	R:R:W91	18.54	No	Yes	0	3	4
106	R:R:H99	R:R:Y101	8.71	No	No	0	4	5
107	R:R:E125	R:R:H99	4.92	No	No	0	5	4
108	R:R:R102	R:R:W110	15.99	No	Yes	0	8	9
109	R:R:F103	R:R:L111	10.96	No	No	0	4	4
110	R:R:F103	R:R:W120	5.01	No	No	9	4	5
111	R:R:E107	R:R:T105	2.82	No	No	0	5	4
112	R:R:L111	R:R:T105	2.95	No	No	0	4	4
113	R:R:P119	R:R:W110	10.81	No	Yes	0	6	9
114	R:R:K113	R:R:S116	6.12	No	No	0	4	5
115	R:R:K113	R:R:L118	4.23	No	No	0	4	4
116	R:R:K113	R:R:W120	4.64	No	No	0	4	5
117	R:R:D114	R:R:N115	2.69	No	No	0	4	4
118	R:R:L123	R:R:R121	13.36	No	No	1	5	6
119	R:R:D122	R:R:S124	2.94	No	No	0	7	5
120	R:R:D122	R:R:E125	12.99	No	No	0	7	5
121	R:R:E127	R:R:S124	2.87	No	No	0	2	5
122	R:R:L141	R:R:Q140	3.99	No	No	0	5	4
123	R:R:F381	R:R:Q140	4.68	No	No	0	4	4
124	R:R:I146	R:R:L142	4.28	No	No	0	4	3
125	R:R:F143	R:R:I147	5.02	No	No	0	4	6
126	R:R:L144	R:R:L384	2.77	No	No	0	6	5
127	R:R:L144	R:R:L388	4.15	No	No	0	6	7
128	R:R:Y145	R:R:Y148	2.98	No	No	0	5	7
129	R:R:D198	R:R:Y145	4.6	No	No	0	7	5
130	R:R:I147	R:R:S389	3.1	No	No	0	6	5
131	R:R:L388	R:R:Y148	9.38	No	No	0	7	7
132	R:R:G151	R:R:V150	3.68	No	No	0	8	5
133	R:R:G151	R:R:S392	3.71	No	No	2	8	9
134	R:R:F393	R:R:G151	4.52	No	No	2	7	8
135	R:R:R190	R:R:Y152	5.14	Yes	Yes	2	8	7
136	R:R:V194	R:R:Y152	5.05	No	Yes	0	7	7
137	R:R:T391	R:R:Y152	3.75	Yes	Yes	2	6	7
138	R:R:S392	R:R:Y152	3.82	No	Yes	2	9	7
139	R:R:G395	R:R:S155	3.71	No	No	0	9	9
140	R:R:L396	R:R:S155	3	No	No	0	7	9
141	R:R:F156	R:R:I188	6.28	No	No	0	7	7
142	R:R:F184	R:R:L159	7.31	No	Yes	0	8	9
143	R:R:F187	R:R:L159	3.65	Yes	Yes	0	8	9
144	R:R:I188	R:R:L159	2.85	No	Yes	0	7	9
145	R:R:A399	R:R:L159	3.15	No	Yes	0	8	9
146	R:R:F404	R:R:I161	3.77	No	No	0	8	4
147	R:R:A162	R:R:C403	3.61	No	Yes	0	9	9
148	R:R:L181	R:R:S163	3	No	No	0	6	6
149	R:R:C403	R:R:I165	3.27	Yes	No	0	9	8
150	R:R:F413	R:R:I165	3.77	No	No	0	5	8
151	R:R:L166	R:R:N177	2.75	Yes	No	0	8	9
152	R:R:L166	R:R:L181	2.77	Yes	No	0	8	6
153	R:R:F184	R:R:L166	3.65	No	Yes	0	8	8
154	R:R:C403	R:R:L166	3.17	Yes	Yes	0	9	8
155	R:R:L167	R:R:L181	2.77	No	No	0	3	6
156	R:R:E412	R:R:F169	12.83	No	No	0	8	7
157	R:R:H173	R:R:R170	5.64	No	No	0	7	8
158	R:R:E412	R:R:H171	4.92	No	No	0	8	7
159	R:R:H173	R:R:Y178	8.71	No	No	0	7	6
160	R:R:C174	R:R:R176	2.79	No	No	0	8	9
161	R:R:C174	R:R:N177	4.72	No	No	0	8	9
162	R:R:T175	R:R:Y250	4.99	No	Yes	0	7	8
163	R:R:H180	R:R:R176	5.64	No	No	0	9	9
164	R:R:F266	R:R:Y178	3.09	No	No	0	6	6
165	R:R:I179	R:R:W243	3.52	No	Yes	0	8	9
166	R:R:E247	R:R:I179	6.83	Yes	No	0	9	8
167	R:R:E247	R:R:H180	6.15	Yes	No	0	9	9
168	R:R:N182	R:R:W243	16.95	No	Yes	11	9	9
169	R:R:N182	R:R:W274	4.52	No	Yes	11	9	9
170	R:R:L183	R:R:S186	3	Yes	No	0	9	9
171	R:R:F187	R:R:L183	6.09	Yes	Yes	0	8	9
172	R:R:L183	R:R:L244	2.77	Yes	No	0	9	9
173	R:R:E247	R:R:L183	13.25	Yes	Yes	0	9	9
174	R:R:N240	R:R:S186	7.45	Yes	No	0	9	9
175	R:R:S186	R:R:W243	4.94	No	Yes	0	9	9
176	R:R:F187	R:R:N240	14.5	Yes	Yes	0	8	9
177	R:R:F187	R:R:Q394	3.51	Yes	Yes	0	8	9
178	R:R:I188	R:R:L192	2.85	No	No	0	7	3
179	R:R:R190	R:R:V237	13.08	Yes	No	0	8	6
180	R:R:N240	R:R:R190	12.05	Yes	Yes	0	9	8
181	R:R:R190	R:R:Y241	11.32	Yes	Yes	2	8	8
182	R:R:R190	R:R:T391	5.17	Yes	Yes	2	8	6
183	R:R:M233	R:R:S193	3.07	No	No	0	6	6
184	R:R:C236	R:R:S193	5.16	No	No	0	5	6
185	R:R:D198	R:R:V194	4.38	No	No	0	7	7
186	R:R:I196	R:R:V229	3.07	No	No	0	5	7
187	R:R:D198	R:R:K197	5.53	No	Yes	0	7	6
188	R:R:K197	R:R:L201	2.82	Yes	No	0	6	7
189	R:R:K197	R:R:M233	2.88	Yes	No	0	6	6
190	R:R:M204	R:R:Y205	5.99	No	Yes	0	3	3
191	R:R:C296	R:R:M204	3.24	No	No	0	9	3
192	R:R:Q210	R:R:T207	2.83	No	No	1	4	3
193	R:R:Q211	R:R:T207	5.67	No	No	1	4	3
194	R:R:A208	R:R:H212	2.93	No	No	0	4	3
195	R:R:Q210	R:R:Q211	6.4	No	No	1	4	4
196	R:R:Q210	R:R:W214	15.33	No	Yes	1	4	1
197	R:R:Q211	R:R:W214	6.57	No	Yes	1	4	1
198	R:R:Q213	R:R:S219	8.66	Yes	No	0	4	5
199	R:R:Q213	R:R:Q221	3.84	Yes	No	0	4	4
200	R:R:S223	R:R:Y220	11.45	No	No	0	4	3
201	R:R:S225	R:R:Y220	7.63	No	No	0	3	3
202	R:R:C226	R:R:Y220	5.38	No	No	0	9	3
203	R:R:D222	R:R:Q221	2.61	No	No	0	6	4
204	R:R:G295	R:R:Q221	3.29	No	No	0	4	4
205	R:R:D222	R:R:R227	7.15	No	Yes	0	6	8
206	R:R:C226	R:R:F230	2.79	No	Yes	13	9	5
207	R:R:C226	R:R:C296	7.28	No	No	13	9	9
208	R:R:D293	R:R:R227	13.1	No	Yes	6	7	8
209	R:R:R227	R:R:W297	23.99	Yes	Yes	6	8	8
210	R:R:F230	R:R:V229	2.62	Yes	No	0	5	7
211	R:R:C296	R:R:F230	2.79	No	Yes	13	9	5
212	R:R:F230	R:R:T298	10.38	Yes	No	0	5	5
213	R:R:L231	R:R:V281	2.98	No	No	0	5	6
214	R:R:M233	R:R:Q234	4.08	No	Yes	0	6	7
215	R:R:Q234	R:R:W284	9.86	Yes	Yes	7	7	8
216	R:R:I309	R:R:Q234	5.49	Yes	Yes	7	7	7
217	R:R:P277	R:R:Y235	8.34	Yes	No	0	9	9
218	R:R:L278	R:R:Y235	4.69	No	No	0	3	9
219	R:R:A238	R:R:F280	2.77	No	Yes	0	6	5
220	R:R:A239	R:R:W274	2.59	No	Yes	0	8	9
221	R:R:L244	R:R:N240	2.75	No	Yes	0	9	9
222	R:R:I313	R:R:Y241	14.51	No	Yes	2	7	8
223	R:R:I317	R:R:Y241	4.84	No	Yes	2	7	8
224	R:R:E364	R:R:Y241	4.49	Yes	Yes	0	8	8
225	R:R:V276	R:R:Y242	7.57	No	Yes	0	3	6
226	R:R:F280	R:R:Y242	4.13	Yes	Yes	14	5	6
227	R:R:P312	R:R:Y242	4.17	No	Yes	14	8	6
228	R:R:V246	R:R:W243	8.58	No	Yes	0	8	9
229	R:R:G273	R:R:W243	8.44	No	Yes	0	9	9
230	R:R:W243	R:R:W274	17.81	Yes	Yes	11	9	9
231	R:R:L244	R:R:Q394	2.66	No	Yes	0	9	9
232	R:R:L245	R:R:V249	2.98	Yes	No	0	8	6
233	R:R:A316	R:R:L245	3.15	No	Yes	0	7	8
234	R:R:L245	R:R:V319	2.98	Yes	No	0	8	6
235	R:R:L245	R:R:N320	5.49	Yes	No	0	8	9
236	R:R:E247	R:R:L359	3.98	Yes	No	0	9	9
237	R:R:T253	R:R:Y250	3.75	No	Yes	10	7	8
238	R:R:L254	R:R:Y250	12.89	No	Yes	0	8	8
239	R:R:Y250	R:R:Y269	3.97	Yes	Yes	10	8	7
240	R:R:L251	R:R:L255	2.77	No	No	4	9	8
241	R:R:L251	R:R:V327	4.47	No	No	4	9	9
242	R:R:I323	R:R:Y252	4.84	No	No	0	8	8
243	R:R:T253	R:R:Y269	3.75	No	Yes	10	7	7
244	R:R:L255	R:R:V327	2.98	No	No	4	8	9
245	R:R:I330	R:R:L255	2.85	No	No	0	9	8
246	R:R:F260	R:R:S258	9.25	No	No	0	7	7
247	R:R:F260	R:R:I265	5.02	No	No	0	7	5
248	R:R:S261	R:R:W264	7.41	No	No	0	7	5
249	R:R:Q263	R:R:R267	4.67	No	No	0	5	4
250	R:R:I265	R:R:W264	4.7	No	No	0	5	5
251	R:R:I265	R:R:Y269	7.25	No	Yes	0	5	7
252	R:R:F266	R:R:V270	3.93	No	No	0	6	5
253	R:R:I272	R:R:L268	4.28	No	No	0	6	2
254	R:R:G273	R:R:I272	3.53	No	No	0	9	6
255	R:R:I272	R:R:V276	4.61	No	No	0	6	3
256	R:R:P277	R:R:V276	3.53	Yes	No	0	9	3
257	R:R:F280	R:R:P277	2.89	Yes	Yes	0	5	9
258	R:R:F280	R:R:V281	2.62	Yes	No	0	5	6
259	R:R:F280	R:R:P312	17.34	Yes	No	14	5	8
260	R:R:I309	R:R:V281	3.07	Yes	No	0	7	6
261	R:R:P283	R:R:V282	3.53	No	No	0	5	3
262	R:R:G285	R:R:W284	2.81	No	Yes	0	5	8
263	R:R:K288	R:R:W284	11.6	No	Yes	0	8	8
264	R:R:I309	R:R:W284	12.92	Yes	Yes	7	7	8
265	R:R:I286	R:R:L290	2.85	No	No	0	4	3
266	R:R:V287	R:R:Y305	8.83	No	Yes	0	4	4
267	R:R:E292	R:R:K288	8.1	Yes	No	0	6	8
268	R:R:K288	R:R:W297	17.4	No	Yes	0	8	8
269	R:R:D293	R:R:Y289	3.45	No	No	6	7	3
270	R:R:W297	R:R:Y289	4.82	Yes	No	6	8	3
271	R:R:L290	R:R:Y291	3.52	No	No	0	3	3
272	R:R:Y291	R:R:Y305	2.98	No	Yes	0	3	4
273	R:R:E292	R:R:S301	7.19	Yes	No	0	6	3
274	R:R:E292	R:R:Y305	4.49	Yes	Yes	0	6	4
275	R:R:D293	R:R:W297	12.28	No	Yes	6	7	8
276	R:R:G295	R:R:R299	4.5	No	No	0	4	4
277	R:R:N300	R:R:W306	13.56	No	No	0	6	6
278	R:R:N302	R:R:N304	8.17	No	No	0	5	3
279	R:R:N302	R:R:Y305	11.63	No	Yes	0	5	4
280	R:R:E373	R:R:M303	5.41	Yes	No	0	4	5
281	R:R:R310	R:R:W306	32.99	No	No	0	6	6
282	R:R:L307	R:R:R310	8.5	No	No	0	7	6
283	R:R:L307	R:R:L311	4.15	No	No	0	7	4
284	R:R:I308	R:R:I309	2.94	No	Yes	0	8	7
285	R:R:E373	R:R:R310	6.98	Yes	No	0	4	6
286	R:R:L311	R:R:P312	3.28	No	No	0	4	8
287	R:R:I313	R:R:I317	2.94	No	No	2	7	7
288	R:R:F315	R:R:V319	3.93	No	No	0	4	6
289	R:R:I317	R:R:V365	3.07	No	No	0	7	6
290	R:R:F321	R:R:V325	2.62	Yes	No	0	6	5
291	R:R:F321	R:R:T362	3.89	Yes	No	0	6	7
292	R:R:F321	R:R:V365	13.11	Yes	No	0	6	6
293	R:R:F324	R:R:I328	6.28	Yes	No	4	9	7
294	R:R:F324	R:R:T353	2.59	Yes	Yes	4	9	9
295	R:R:F324	R:R:L356	6.09	Yes	Yes	4	9	9
296	R:R:F324	R:R:T362	6.49	Yes	No	0	9	7
297	R:R:R326	R:R:V325	5.23	No	No	0	8	5
298	R:R:L356	R:R:V327	2.98	Yes	No	4	9	9
299	R:R:I328	R:R:T353	6.08	No	Yes	4	7	9
300	R:R:I328	R:R:L356	2.85	No	Yes	4	7	9
301	R:R:I330	R:R:K334	2.91	No	No	0	9	9
302	R:R:L335	R:R:V331	2.98	No	No	0	8	8
303	R:R:L349	R:R:V332	4.47	No	No	0	9	6
304	R:R:L335	R:R:N338	2.75	No	No	0	8	6
305	R:R:I345	R:R:L335	4.28	No	No	0	5	8
306	R:R:I345	R:R:K336	4.36	No	No	0	5	6
307	R:R:K351	R:R:R348	11.14	No	No	0	8	8
308	R:R:L349	R:R:T353	2.95	No	Yes	0	9	9
309	R:R:K351	R:R:T355	3	No	No	0	8	8
310	R:R:S352	R:R:T353	3.2	No	Yes	0	9	9
311	R:R:L401	R:R:T355	4.42	No	No	0	8	8
312	R:R:L356	R:R:L360	4.15	Yes	No	0	9	9
313	R:R:I357	R:R:P358	3.39	No	No	0	8	9
314	R:R:I357	R:R:T362	4.56	No	No	0	8	7
315	R:R:M397	R:R:P358	6.71	No	No	0	5	9
316	R:R:L359	R:R:L360	5.54	No	No	0	9	9
317	R:R:L359	R:R:Y402	15.24	No	No	0	9	8
318	R:R:G361	R:R:H363	3.18	No	Yes	12	9	8
319	R:R:G361	R:R:Q394	4.93	No	Yes	12	9	9
320	R:R:E364	R:R:H363	16	Yes	Yes	0	8	8
321	R:R:F390	R:R:H363	10.18	No	Yes	0	6	8
322	R:R:H363	R:R:Q394	11.13	Yes	Yes	12	8	9
323	R:R:E364	R:R:E387	6.34	Yes	No	0	8	8
324	R:R:E364	R:R:T391	7.06	Yes	Yes	0	8	6
325	R:R:F367	R:R:I366	7.54	No	No	0	7	6
326	R:R:F367	R:R:T386	7.78	No	No	0	7	4
327	R:R:A368	R:R:F369	2.77	No	No	0	6	4
328	R:R:E373	R:R:M371	2.71	Yes	No	0	4	7
329	R:R:D372	R:R:R380	5.96	No	Yes	0	5	5
330	R:R:A375	R:R:R380	6.91	No	Yes	0	4	5
331	R:R:E387	R:R:K383	10.8	No	No	0	8	7
332	R:R:F385	R:R:S389	3.96	No	No	0	6	5
333	R:R:F390	R:R:T386	2.59	No	No	0	6	4
334	R:R:F393	R:R:S392	6.61	No	No	2	7	9
335	R:R:L401	R:R:Y402	12.89	No	No	0	8	8
336	R:R:C403	R:R:F404	5.59	Yes	No	0	9	8
337	R:R:N406	R:R:N407	4.09	No	No	15	9	6
338	R:R:E408	R:R:N406	13.15	No	No	15	9	9
339	R:R:N406	R:R:V409	4.43	No	No	0	9	9
340	R:R:E408	R:R:N407	11.83	No	No	15	9	6
341	R:R:F413	R:R:V409	2.62	No	No	0	5	9
342	R:R:E412	R:R:K415	6.75	No	No	0	8	7
343	R:R:K415	R:R:R419	6.19	No	No	0	7	7
344	R:R:E418	R:R:W417	7.63	No	No	0	4	5
345	R:R:R421	R:R:W417	9	No	No	0	4	5
346	R:R:R421	R:R:W420	7	No	No	0	4	4
347	R:R:V249	R:R:Y269	2.52	No	Yes	0	6	7
348	R:R:F266	R:R:I179	2.51	No	No	0	6	8
349	R:R:F381	R:R:I382	2.51	No	No	0	4	4
350	R:R:F404	R:R:I400	2.51	No	No	0	8	6
351	R:R:T149	R:R:Y145	2.5	No	No	0	7	5
352	R:R:S416	R:R:W420	2.47	No	No	0	5	4
353	R:R:E373	R:R:H374	2.46	Yes	No	0	4	3
354	R:R:F169	R:R:L172	2.44	No	No	0	7	9
355	R:R:D74	R:R:R64	2.38	No	No	0	3	4
356	R:R:L245	R:R:Y242	2.34	Yes	Yes	0	8	6
357	R:R:L32	R:R:W214	2.28	No	Yes	0	4	1
358	R:R:L189	R:R:W274	2.28	No	Yes	0	7	9
359	L:L:E27	R:R:W214	2.18	No	Yes	0	0	1
360	R:R:E423	R:R:W420	2.18	No	No	0	4	4
361	R:R:F66	R:R:R43	2.14	Yes	No	0	7	4
362	R:R:F80	R:R:Y101	2.06	No	No	0	4	5
363	R:R:G275	R:R:P277	2.03	No	Yes	0	6	9
364	R:R:F66	R:R:W39	2	Yes	Yes	0	7	5
365	R:R:C62	R:R:G75	1.96	Yes	No	3	9	7
366	R:R:C62	R:R:G108	1.96	Yes	No	0	9	9
367	R:R:C104	R:R:G75	1.96	No	No	3	9	7
368	R:R:P54	R:R:P55	1.95	No	No	0	2	1
369	R:R:P55	R:R:P56	1.95	No	Yes	0	1	1
370	R:R:A106	R:R:G78	1.95	No	No	0	1	7
371	L:L:A25	R:R:P90	1.87	No	Yes	0	0	4
372	R:R:A70	R:R:P86	1.87	No	Yes	0	5	8
373	R:R:A106	R:R:P77	1.87	No	No	0	1	4
374	R:R:A158	R:R:A399	1.79	No	No	0	7	8
375	R:R:P73	R:R:V83	1.77	No	No	0	5	5
376	R:R:P96	R:R:V95	1.77	No	No	0	3	5
377	R:R:P358	R:R:V398	1.77	No	No	0	9	9
378	R:R:G248	R:R:I323	1.76	No	No	0	8	8
379	R:R:G108	R:R:L60	1.71	No	No	0	9	1
380	R:R:G395	R:R:L159	1.71	No	Yes	0	9	9
381	R:R:A209	R:R:S206	1.71	No	No	0	1	4
382	R:R:G248	R:R:L360	1.71	No	No	0	8	9
383	R:R:C329	R:R:V325	1.71	No	No	0	7	5
384	R:R:A208	R:R:T207	1.68	No	No	0	4	3
385	R:R:G98	R:R:Q97	1.64	No	No	0	4	4
386	R:R:L118	R:R:P119	1.64	No	No	0	4	6
387	R:R:S94	R:R:V95	1.62	No	No	0	4	5
388	R:R:S352	R:R:V331	1.62	No	No	0	9	8
389	R:R:G98	R:R:H99	1.59	No	No	0	4	4
390	R:R:C236	R:R:L232	1.59	No	No	0	5	5
391	R:R:A92	R:R:L89	1.58	No	Yes	0	5	5
392	R:R:A153	R:R:L154	1.58	No	No	0	6	5
393	R:R:I161	R:R:V160	1.54	No	No	0	4	3
394	R:R:I286	R:R:V282	1.54	No	No	0	4	3
395	R:R:A209	R:R:Q213	1.52	No	Yes	0	1	4
396	R:R:K383	R:R:V370	1.52	No	No	0	7	5
397	R:R:I382	R:R:T378	1.52	No	No	0	4	2
398	L:L:A30	L:L:E27	1.51	No	No	0	0	0
399	R:R:F321	R:R:G318	1.51	Yes	No	0	6	4
400	R:R:G377	R:R:R376	1.5	No	No	0	4	5
401	L:L:?18	L:L:G22	1.49	No	No	0	0	0
402	R:R:L154	R:R:V150	1.49	No	No	0	5	5
403	R:R:L379	R:R:V370	1.49	No	No	0	3	5
404	R:R:I345	R:R:K346	1.45	No	No	0	5	6
405	R:R:I357	R:R:L354	1.43	No	No	0	8	8
406	R:R:E262	R:R:T175	1.41	No	No	0	6	7
407	R:R:K415	R:R:L411	1.41	No	No	0	7	4
408	R:R:A153	R:R:F195	1.39	No	No	0	6	7
409	R:R:A191	R:R:F156	1.39	No	No	0	7	7
410	R:R:A191	R:R:F195	1.39	No	No	0	7	7
411	R:R:L166	R:R:L172	1.38	Yes	No	0	8	9
412	R:R:L224	R:R:L228	1.38	No	No	0	3	4
413	R:R:D59	R:R:L60	1.36	No	No	0	3	1
414	R:R:E41	R:R:K38	1.35	No	No	0	4	4
415	R:R:E107	R:R:L109	1.33	No	No	0	5	5
416	R:R:R267	R:R:V270	1.31	No	No	0	4	5
417	R:R:A185	R:R:W274	1.3	No	Yes	0	3	9
418	R:R:F385	R:R:T386	1.3	No	No	0	6	4
419	L:L:E27	L:L:Q23	1.27	No	No	0	0	0
420	R:R:E292	R:R:E294	1.27	Yes	No	0	6	4
421	R:R:S94	R:R:W91	1.24	No	Yes	0	4	4
422	R:R:L224	R:R:R227	1.21	No	Yes	0	3	8
423	R:R:Q47	R:R:R48	1.17	No	No	0	3	4
424	R:R:R376	R:R:R380	1.07	No	Yes	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:H7	5.1725	4	0	0
2	L:L:E9	5.5625	4	2	0
3	L:L:F12	5.035	4	0	0
4	L:L:F28	7.40833	6	1	0
5	L:L:I29	4.358	5	1	0
6	R:R:S31	7.8925	4	5	4
7	R:R:W39	10.3875	4	0	5
8	R:R:Y42	9.0175	4	1	6
9	R:R:P56	12.695	4	3	1
10	R:R:F61	11.345	6	3	3
11	R:R:C62	4.105	4	3	9
12	R:R:F66	4.1775	4	8	7
13	R:R:Y69	5.63	7	1	6
14	R:R:W72	10.265	4	0	9
15	R:R:P86	5.36167	6	1	8
16	R:R:Y88	9.176	5	1	5
17	R:R:L89	5.65167	6	1	5
18	R:R:P90	4.31	4	1	4
19	R:R:W91	8.768	5	1	4
20	R:R:W110	10.735	4	0	9
21	R:R:Y152	4.45	5	2	7
22	R:R:L159	3.734	5	0	9
23	R:R:L166	2.744	5	0	8
24	R:R:L183	6.2775	4	0	9
25	R:R:F187	6.9375	4	0	8
26	R:R:R190	9.15	6	2	8
27	R:R:K197	5.06	4	0	6
28	R:R:Y205	7.95	4	0	3
29	R:R:Q213	4.17	4	0	4
30	R:R:W214	10.4917	6	1	1
31	R:R:R227	11.3625	4	6	8
32	R:R:F230	4.645	4	13	5
33	R:R:Q234	6.7125	4	7	7
34	R:R:N240	9.1875	4	0	9
35	R:R:Y241	8.79	4	2	8
36	R:R:Y242	4.5525	4	14	6
37	R:R:W243	10.04	6	11	9
38	R:R:L245	3.388	5	0	8
39	R:R:E247	7.5525	4	0	9
40	R:R:Y250	6.4	4	10	8
41	R:R:Y269	4.3725	4	10	7
42	R:R:W274	5.7	5	11	9
43	R:R:P277	4.1975	4	0	9
44	R:R:F280	5.95	5	14	5
45	R:R:W284	9.2975	4	7	8
46	R:R:E292	5.2625	4	0	6
47	R:R:W297	14.6225	4	6	8
48	R:R:Y305	6.9825	4	0	4
49	R:R:I309	6.105	4	7	7
50	R:R:F321	5.2825	4	0	6
51	R:R:F324	5.3625	4	4	9
52	R:R:T353	3.705	4	4	9
53	R:R:L356	4.0175	4	4	9
54	R:R:H363	10.1225	4	12	8
55	R:R:E364	8.4725	4	0	8
56	R:R:E373	4.39	4	0	4
57	R:R:R380	4.675	4	0	5
58	R:R:T391	5.405	4	2	6
59	R:R:Q394	5.5575	4	12	9
60	R:R:C403	3.91	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:H7	R:R:Q234	84.7045	7.42	Yes	Yes	0	0	7
2	L:L:H7	R:R:V237	88.1204	6.92	Yes	No	0	0	6
3	L:L:H7	R:R:W306	16.6177	3.17	Yes	No	0	0	6
4	R:R:R190	R:R:Y241	31.5082	11.32	Yes	Yes	2	8	8
5	R:R:R190	R:R:V237	88.2638	13.08	Yes	No	0	8	6
6	R:R:E364	R:R:T391	11.4745	7.06	Yes	Yes	0	8	6
7	L:L:E9	R:R:R190	30.5136	8.14	Yes	Yes	2	0	8
8	L:L:E9	R:R:L388	34.7489	3.98	Yes	No	0	0	7
9	L:L:F12	R:R:L144	16.991	3.65	Yes	No	0	0	6
10	R:R:L144	R:R:L388	17.4916	4.15	No	No	0	6	7
11	L:L:F12	R:R:Y148	20.0269	5.16	Yes	No	0	0	7
12	R:R:L388	R:R:Y148	17.5098	9.38	No	No	0	7	7
13	L:L:F12	L:L:V16	32.7143	5.24	Yes	No	0	0	0
14	L:L:L20	L:L:V16	32.0111	2.98	No	No	0	0	0
15	R:R:C296	R:R:F230	10.5755	2.79	No	Yes	13	9	5
16	R:R:C296	R:R:M204	18.1038	3.24	No	No	0	9	3
17	R:R:M204	R:R:Y205	19.5831	5.99	No	Yes	0	3	3
18	L:L:L20	R:R:Y205	30.0517	16.41	No	Yes	0	0	3
19	L:L:E21	R:R:Y205	20.7665	6.73	No	Yes	0	0	3
20	L:L:E21	R:R:R299	14.6128	8.14	No	No	5	0	4
21	R:R:G295	R:R:R299	17.1366	4.5	No	No	0	4	4
22	R:R:G295	R:R:Q221	17.0706	3.29	No	No	0	4	4
23	R:R:D222	R:R:Q221	91.4977	2.61	No	No	0	6	4
24	R:R:D222	R:R:R227	91.7685	7.15	No	Yes	0	6	8
25	R:R:R227	R:R:W297	91.83	23.99	Yes	Yes	6	8	8
26	R:R:K288	R:R:W297	93.0794	17.4	No	Yes	0	8	8
27	R:R:K288	R:R:W284	96.4521	11.6	No	Yes	0	8	8
28	R:R:Q234	R:R:W284	81.8029	9.86	Yes	Yes	7	7	8
29	R:R:Q213	R:R:Q221	100	3.84	Yes	No	0	4	4
30	R:R:L32	R:R:Q213	98.1339	2.66	No	Yes	0	4	4
31	R:R:L32	R:R:W214	97.6559	2.28	No	Yes	0	4	1
32	L:L:F28	R:R:W214	78.8216	15.03	Yes	Yes	1	0	1
33	L:L:F28	L:L:I29	64.4182	3.77	Yes	Yes	1	0	0
34	L:L:W31	R:R:W214	12.7421	21.56	No	Yes	1	0	1
35	L:L:F28	L:L:L32	12.2619	12.18	Yes	No	1	0	0
36	L:L:L32	L:L:W31	11.9865	3.42	No	No	1	0	0
37	L:L:I29	R:R:L89	58.1416	2.85	Yes	Yes	1	0	5
38	L:L:L32	R:R:W39	22.7851	22.78	No	Yes	0	0	5
39	R:R:L89	R:R:Y69	48.6288	4.69	Yes	Yes	1	5	6
40	R:R:W39	R:R:Y88	12.3097	13.5	Yes	Yes	0	5	5
41	R:R:F66	R:R:W39	11.5177	2	Yes	Yes	0	7	5
42	R:R:Q45	R:R:Y42	10.3275	6.76	No	Yes	0	5	6
43	R:R:V100	R:R:Y69	47.1997	5.05	No	Yes	0	7	6
44	R:R:V100	R:R:W72	46.4077	6.13	No	Yes	0	7	9
45	R:R:R102	R:R:W72	43.1237	18.99	No	Yes	0	8	9
46	R:R:R102	R:R:W110	42.2908	15.99	No	Yes	0	8	9
47	R:R:C62	R:R:W110	21.827	5.22	Yes	Yes	0	9	9
48	R:R:C62	R:R:G75	17.0205	1.96	Yes	No	3	9	7
49	R:R:F61	R:R:G75	16.092	6.02	Yes	No	3	3	7
50	R:R:P119	R:R:W110	19.9335	10.81	No	Yes	0	6	9
51	R:R:L118	R:R:P119	18.98	1.64	No	No	0	4	6
52	R:R:K113	R:R:L118	18.0219	4.23	No	No	0	4	4
53	R:R:K113	R:R:W120	16.092	4.64	No	No	0	4	5
54	R:R:F80	R:R:W120	10.0794	4.01	No	No	9	4	5
55	R:R:E364	R:R:H363	12.8877	16	Yes	Yes	0	8	8
56	R:R:F390	R:R:H363	13.6524	10.18	No	Yes	0	6	8
57	R:R:F390	R:R:T386	11.9615	2.59	No	No	0	6	4
58	R:R:N240	R:R:R190	80.929	12.05	Yes	Yes	0	9	8
59	R:R:F187	R:R:N240	43.4765	14.5	Yes	Yes	0	8	9
60	R:R:F187	R:R:L159	36.9473	3.65	Yes	Yes	0	8	9
61	R:R:F184	R:R:L159	26.4923	7.31	No	Yes	0	8	9
62	R:R:F184	R:R:L166	25.5047	3.65	No	Yes	0	8	8
63	R:R:C403	R:R:L166	14.3943	3.17	Yes	Yes	0	9	8
64	R:R:N240	R:R:S186	31.7266	7.45	Yes	No	0	9	9
65	R:R:S186	R:R:W243	22.9194	4.94	No	Yes	0	9	9
66	R:R:I179	R:R:W243	10.6506	3.52	No	Yes	0	8	9
67	R:R:L183	R:R:S186	18.5681	3	Yes	No	0	9	9
68	R:R:E247	R:R:L183	44.8556	13.25	Yes	Yes	0	9	9
69	R:R:F187	R:R:L183	23.2607	6.09	Yes	Yes	0	8	9
70	R:R:L244	R:R:N240	16.0215	2.75	No	Yes	0	9	9
71	R:R:L183	R:R:L244	15.5663	2.77	Yes	No	0	9	9
72	R:R:I309	R:R:V281	20.391	3.07	Yes	No	0	7	6
73	R:R:F280	R:R:V281	19.2941	2.62	Yes	No	0	5	6
74	R:R:F280	R:R:Y242	13.3179	4.13	Yes	Yes	14	5	6
75	R:R:L245	R:R:Y242	19.8061	2.34	Yes	Yes	0	8	6
76	R:R:L245	R:R:V249	14.1167	2.98	Yes	No	0	8	6
77	R:R:V249	R:R:Y269	12.9651	2.52	No	Yes	0	6	7
78	R:R:I317	R:R:Y241	22.9831	4.84	No	Yes	2	7	8
79	R:R:V276	R:R:Y242	12.6624	7.57	No	Yes	0	3	6
80	R:R:G273	R:R:W243	16.1671	8.44	No	Yes	0	9	9
81	R:R:E247	R:R:L359	43.2648	3.98	Yes	No	0	9	9
82	R:R:L359	R:R:L360	30.4567	5.54	No	No	0	9	9
83	R:R:L356	R:R:L360	21.8998	4.15	Yes	No	0	9	9
84	R:R:L356	R:R:V327	14.6651	2.98	Yes	No	4	9	9
85	R:R:I317	R:R:V365	22.157	3.07	No	No	0	7	6
86	R:R:F321	R:R:V365	21.2967	13.11	Yes	No	0	6	6
87	R:R:F321	R:R:T362	17.28	3.89	Yes	No	0	6	7
88	R:R:F324	R:R:T362	14.4125	6.49	Yes	No	0	9	7
89	R:R:I272	R:R:V276	16.7543	4.61	No	No	0	6	3
90	R:R:G273	R:R:I272	16.2855	3.53	No	No	0	9	6
91	R:R:E292	R:R:K288	12.2596	8.1	Yes	No	0	6	8
92	R:R:F324	R:R:T353	10.1932	2.59	Yes	Yes	4	9	9
93	R:R:L359	R:R:Y402	11.7066	15.24	No	No	0	9	8
94	R:R:I309	R:R:W284	15.1248	12.92	Yes	Yes	7	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:H7	R:R:Q234	7.42	0	Yes	Yes	0	7	0	1
L:L:H7	R:R:V237	6.92	0	Yes	No	0	6	0	1
L:L:H7	R:R:W306	3.17	0	Yes	No	0	6	0	1
L:L:A8	R:R:E387	6.03	0	No	No	0	8	0	1
L:L:E9	R:R:Y152	4.49	2	Yes	Yes	0	7	0	1
L:L:E9	R:R:R190	8.14	2	Yes	Yes	0	8	0	1
L:L:E9	R:R:L388	3.98	2	Yes	No	0	7	0	1
L:L:E9	R:R:T391	5.64	2	Yes	Yes	0	6	0	1
L:L:T11	R:R:D372	5.78	0	No	No	0	5	0	1
L:L:F12	R:R:L141	6.09	0	Yes	No	0	5	0	1
L:L:F12	R:R:L144	3.65	0	Yes	No	0	6	0	1
L:L:F12	R:R:Y148	5.16	0	Yes	No	0	7	0	1
L:L:T13	R:R:K197	9.01	0	No	Yes	0	6	0	1
L:L:S14	R:R:N300	2.98	0	No	No	0	6	0	1
L:L:D15	R:R:R380	4.76	0	No	Yes	0	5	0	1
L:L:S17	R:R:T298	6.4	0	No	No	0	5	0	1
L:L:Y19	R:R:E138	17.96	0	No	No	0	2	0	1
L:L:L20	R:R:Y205	16.41	0	No	Yes	0	3	0	1
L:L:E21	R:R:S31	10.06	5	No	Yes	0	4	0	1
L:L:E21	R:R:Y205	6.73	5	No	Yes	0	3	0	1
L:L:E21	R:R:R299	8.14	5	No	No	0	4	0	1
L:L:A24	R:R:Y205	2.67	0	No	Yes	0	3	0	1
L:L:K26	R:R:E128	10.8	0	No	No	0	3	0	1
L:L:F28	R:R:T35	2.59	1	Yes	No	0	5	0	1
L:L:F28	R:R:V36	7.87	1	Yes	No	0	2	0	1
L:L:F28	R:R:W214	15.03	1	Yes	Yes	0	1	0	1
L:L:I29	R:R:T35	3.04	1	Yes	No	0	5	0	1
L:L:I29	R:R:L89	2.85	1	Yes	Yes	0	5	0	1
L:L:I29	R:R:P90	5.08	1	Yes	Yes	0	4	0	1
L:L:I29	R:R:W91	7.05	1	Yes	Yes	0	4	0	1
L:L:W31	R:R:W214	21.56	1	No	Yes	0	1	0	1
L:L:L32	R:R:W39	22.78	1	No	Yes	0	5	0	1
L:L:V33	R:R:Y69	5.05	1	No	Yes	0	6	0	1
L:L:V33	R:R:L123	4.47	1	No	No	0	5	0	1
R:R:T35	R:R:V30	3.17	1	No	No	5	2	1	2
R:R:P90	R:R:V30	3.53	1	Yes	No	4	2	1	2
R:R:S31	R:R:W33	6.18	5	Yes	No	4	3	1	2
R:R:E34	R:R:S31	10.06	5	No	Yes	4	4	2	1
R:R:R299	R:R:S31	5.27	5	No	Yes	4	4	1	1
R:R:E34	R:R:W33	7.63	5	No	No	4	3	2	2
R:R:E68	R:R:W39	3.27	0	No	Yes	4	5	2	1
R:R:W39	R:R:Y88	13.5	0	Yes	Yes	5	5	1	2
R:R:P86	R:R:Y69	6.95	1	Yes	Yes	8	6	2	1
R:R:L89	R:R:Y69	4.69	1	Yes	Yes	5	6	1	1
R:R:V100	R:R:Y69	5.05	0	No	Yes	7	6	2	1
R:R:R121	R:R:Y69	3.09	1	No	Yes	6	6	2	1
R:R:L123	R:R:Y69	10.55	1	No	Yes	5	6	1	1
R:R:C126	R:R:Y69	4.03	0	No	Yes	9	6	2	1
R:R:P86	R:R:Y88	6.95	1	Yes	Yes	8	5	2	2
R:R:L89	R:R:P86	9.85	1	Yes	Yes	5	8	1	2
R:R:L89	R:R:Y88	4.69	1	Yes	Yes	5	5	1	2
R:R:L89	R:R:W91	10.25	1	Yes	Yes	5	4	1	1
R:R:P90	R:R:W91	6.76	1	Yes	Yes	4	4	1	1
R:R:E128	R:R:W91	18.54	0	No	Yes	3	4	1	1
R:R:L123	R:R:R121	13.36	1	No	No	5	6	1	2
R:R:L141	R:R:Q140	3.99	0	No	No	5	4	1	2
R:R:L144	R:R:L384	2.77	0	No	No	6	5	1	2
R:R:L144	R:R:L388	4.15	0	No	No	6	7	1	1
R:R:Y145	R:R:Y148	2.98	0	No	No	5	7	2	1
R:R:D198	R:R:Y145	4.6	0	No	No	7	5	2	2
R:R:L388	R:R:Y148	9.38	0	No	No	7	7	1	1
R:R:R190	R:R:Y152	5.14	2	Yes	Yes	8	7	1	1
R:R:V194	R:R:Y152	5.05	0	No	Yes	7	7	2	1
R:R:T391	R:R:Y152	3.75	2	Yes	Yes	6	7	1	1
R:R:S392	R:R:Y152	3.82	2	No	Yes	9	7	2	1
R:R:R190	R:R:V237	13.08	2	Yes	No	8	6	1	1
R:R:N240	R:R:R190	12.05	0	Yes	Yes	9	8	2	1
R:R:R190	R:R:Y241	11.32	2	Yes	Yes	8	8	1	2
R:R:R190	R:R:T391	5.17	2	Yes	Yes	8	6	1	1
R:R:D198	R:R:V194	4.38	0	No	No	7	7	2	2
R:R:D198	R:R:K197	5.53	0	No	Yes	7	6	2	1
R:R:K197	R:R:L201	2.82	0	Yes	No	6	7	1	2
R:R:K197	R:R:M233	2.88	0	Yes	No	6	6	1	2
R:R:M204	R:R:Y205	5.99	0	No	Yes	3	3	2	1
R:R:Q210	R:R:Q211	6.4	1	No	No	4	4	2	2
R:R:Q210	R:R:W214	15.33	1	No	Yes	4	1	2	1
R:R:Q211	R:R:W214	6.57	1	No	Yes	4	1	2	1
R:R:F230	R:R:T298	10.38	13	Yes	No	5	5	2	1
R:R:M233	R:R:Q234	4.08	0	No	Yes	6	7	2	1
R:R:Q234	R:R:W284	9.86	7	Yes	Yes	7	8	1	2
R:R:I309	R:R:Q234	5.49	7	Yes	Yes	7	7	2	1
R:R:E364	R:R:Y241	4.49	0	Yes	Yes	8	8	2	2
R:R:I309	R:R:W284	12.92	7	Yes	Yes	7	8	2	2
R:R:G295	R:R:R299	4.5	0	No	No	4	4	2	1
R:R:N300	R:R:W306	13.56	0	No	No	6	6	1	1
R:R:R310	R:R:W306	32.99	0	No	No	6	6	2	1
R:R:E364	R:R:E387	6.34	0	Yes	No	8	8	2	1
R:R:E364	R:R:T391	7.06	0	Yes	Yes	8	6	2	1
R:R:D372	R:R:R380	5.96	0	No	Yes	5	5	1	1
R:R:A375	R:R:R380	6.91	0	No	Yes	4	5	2	1
R:R:E387	R:R:K383	10.8	0	No	No	8	7	1	2
R:R:L32	R:R:W214	2.28	0	No	Yes	4	1	2	1
L:L:E27	R:R:W214	2.18	0	No	Yes	0	1	0	1
R:R:F66	R:R:W39	2	8	Yes	Yes	7	5	2	1
L:L:A25	R:R:P90	1.87	0	No	Yes	0	4	0	1
R:R:A92	R:R:L89	1.58	0	No	Yes	5	5	2	1
R:R:S94	R:R:W91	1.24	0	No	Yes	4	4	2	1
R:R:R376	R:R:R380	1.07	0	No	Yes	5	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9EBO_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.59
Number of Linked Nodes	372
Number of Links	424
Number of Hubs	60
Number of Links mediated by Hubs	217
Number of Communities	15
Number of Nodes involved in Communities	81
Number of Links involved in Communities	104

Path Summary
Number Of Nodes in MetaPath	95
Number Of Links MetaPath	94
Number of Shortest Paths	105839
Length Of Smallest Path	3
Average Path Length	17.4724
Length of Longest Path	44
Minimum Path Strength	1.285
Average Path Strength	7.13898
Maximum Path Strength	23.275
Minimum Path Correlation	0.7
Average Path Correlation	0.961181
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	61.3539
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.8293
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • synapse • cell junction • hormone activity • molecular function activator activity • signaling receptor binding • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • G protein-coupled receptor binding • glucagon receptor binding • identical protein binding • monosaccharide metabolic process • positive regulation of biological process • gluconeogenesis • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • small molecule metabolic process • regulation of carbohydrate metabolic process • regulation of glucose metabolic process • positive regulation of cellular process • positive regulation of gluconeogenesis • regulation of biosynthetic process • carbohydrate metabolic process • small molecule biosynthetic process • carbohydrate biosynthetic process • hexose metabolic process • primary metabolic process • monosaccharide biosynthetic process • hexose biosynthetic process • positive regulation of glucose metabolic process • biosynthetic process • regulation of gluconeogenesis • metabolic process • positive regulation of carbohydrate metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • glucose metabolic process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • positive regulation of cell communication • positive regulation of establishment of protein localization • carbohydrate homeostasis • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • positive regulation of peptide hormone secretion • intracellular glucose homeostasis • cellular response to carbohydrate stimulus • chemical homeostasis • response to glucose • glucose homeostasis • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • homeostatic process • positive regulation of secretion by cell • positive regulation of protein transport • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • cellular response to hexose stimulus • intracellular chemical homeostasis • cellular response to monosaccharide stimulus • positive regulation of peptide secretion • cellular response to glucose stimulus • positive regulation of protein secretion • response to hexose • cellular homeostasis • positive regulation of transport • regulation of cellular localization • regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of signaling • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • regulation of calcium ion import • regulation of calcium ion transport • positive regulation of calcium ion transport • positive regulation of calcium ion import • regulation of monoatomic ion transport • calcium ion transport • metal ion transport • positive regulation of monoatomic ion transport • monoatomic ion transport • calcium ion import • monoatomic cation transport • regulation of metal ion transport • lipid biosynthetic process • lipid metabolic process • negative regulation of programmed cell death • regulation of apoptotic process • negative regulation of biological process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • negative regulation of cellular process • apoptotic process • programmed cell death • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • lactate biosynthetic process • monocarboxylic acid biosynthetic process • oxoacid metabolic process • carboxylic acid metabolic process • organic acid biosynthetic process • organic acid metabolic process • carboxylic acid biosynthetic process • lactate metabolic process • monocarboxylic acid metabolic process • response to activity • negative regulation of execution phase of apoptosis • regulation of execution phase of apoptosis • execution phase of apoptosis • glucagon receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • amide binding • peptide hormone binding • hormone binding • glucagon-like peptide 1 receptor activity • positive regulation of cytosolic calcium ion concentration • heart process • multicellular organismal process • system process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • regulation of blood pressure • positive regulation of blood pressure • response to stress • response to psychosocial stress • cell surface receptor signaling pathway • behavior • learning or memory • nervous system process • cognition • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • protein targeting • protein transmembrane transport • post-translational protein targeting to membrane, translocation • establishment of protein localization to endoplasmic reticulum • establishment of protein localization to membrane • intracellular protein transmembrane transport • intracellular transport • post-translational protein targeting to endoplasmic reticulum membrane • localization within membrane • protein targeting to membrane • transmembrane transport • establishment of protein localization to organelle • intracellular protein transport • protein targeting to ER • negative regulation of blood pressure • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • FnI-like domain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • FnI-like domain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	XCP
PDB Residues	L:L:?18
Environment Details	Open EMBL-EBI Page
Code	XCP
Name	(1S,2S)-2-aminocyclopentanecarboxylic acid
Synonyms
Identifier
Formula	C6 H11 N O2
Molecular Weight	129.157
SMILES
PubChem	10997062
Formal Charge	0
Total Atoms	20
Total Chiral Atoms	2
Total Bonds	20
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P43220
Sequence	>9EBO_nogp_Chain_R V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F R H L H C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S T A A Q Q H Q W D S Y Q D S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S V S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E D E G C W T R N S N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N D I K C R L A K S T L T L I P L L G T H E V I F A F V M D E H A R G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E V Q L E F R K S W E R W R L E F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6ORV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2	Gs/β1/γ2	3	2020-01-08	doi.org/10.1038/s41586-019-1902-z
	6ORV (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2		3	2020-01-08	doi.org/10.1038/s41586-019-1902-z
	7E14	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738	Gs/β1/γ2	2.9	2021-07-07	doi.org/10.1038/s41467-021-24058-z
	7E14 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738		2.9	2021-07-07	doi.org/10.1038/s41467-021-24058-z
	7DUQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738	Gs/β1/γ2	2.5	2021-07-14	doi.org/10.1038/s41467-021-24058-z
	7DUQ (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738		2.5	2021-07-14	doi.org/10.1038/s41467-021-24058-z
	7DUR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	3.3	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7DUR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		3.3	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7EVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	2.5	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7EVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		2.5	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	5VEW	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.7	2017-05-24	doi.org/10.1038/nature22378
	6LN2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	3.2	2020-03-18	doi.org/10.1038/s41467-020-14934-5
	6KJV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.8	2019-11-13	doi.org/10.1107/S2052252519013496
	6KK1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.8	2019-11-13	doi.org/10.1107/S2052252519013496
	6KK7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	3.1	2019-11-13	doi.org/10.1107/S2052252519013496
	5VEX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	NNC0640	-	3	2017-05-17	doi.org/10.1038/nature22378
	9IVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839	chim(NtGi1-Gs)/β2/γ2	3.22	2024-11-13	doi.org/10.1016/j.apsb.2024.09.002
	9IVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839		3.22	2024-11-13	doi.org/10.1016/j.apsb.2024.09.002
	6VCB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440	Gs/β1/γ2	3.3	2020-07-22	doi.org/10.1038/s41589-020-0589-7
	6VCB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440		3.3	2020-07-22	doi.org/10.1038/s41589-020-0589-7
	9IVG	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	chim(NtGi1-Gs)/β1/γ2	3	2024-11-27	doi.org/10.1016/j.apsb.2024.09.002
	9IVG (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-		3	2024-11-27	doi.org/10.1016/j.apsb.2024.09.002
	7RTB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-	Gs/β1/γ2	2.14	2021-10-06	doi.org/10.1016/j.bbrc.2021.09.016
	7RTB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-		2.14	2021-10-06	doi.org/10.1016/j.bbrc.2021.09.016
	7KI0	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-	Gs/β1/γ2	2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI0 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-		2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-	Gs/β1/γ2	2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI1 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-		2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	6X18	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-	Gs/β1/γ2	2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X18 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-		2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X19	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-	Gs/β1/γ2	2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X19 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-		2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X1A	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.5	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X1A (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.5	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	7LCI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.9	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.9	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCJ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	2.82	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCK	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	3.24	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7S15	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 134611223	-	-	3.8	2022-06-08	doi.org/10.1021/acs.jmedchem.1c01856
	9J1P	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-	chim(NtGi1-Gs)/β1/γ2	2.99	2025-02-26	doi.org/10.1021/jacs.4c12808
	9J1P (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-		2.99	2025-02-26	doi.org/10.1021/jacs.4c12808
	5VAI	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-	Gs/β1/γ2	4.1	2017-05-24	doi.org/10.1038/nature22394
	5VAI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-		4.1	2017-05-24	doi.org/10.1038/nature22394
	5NX2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	-	3.7	2017-06-14	doi.org/10.1038/nature22800
	6B3J	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-	Gs/β1/γ2	3.3	2018-02-21	doi.org/10.1038/nature25773
	6B3J (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-		3.3	2018-02-21	doi.org/10.1038/nature25773
	8WG7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.54	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	8WG7 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.54	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	7C2E	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-	Gs/β1/γ2	4.2	2020-08-26	doi.org/10.1038/s41422-020-0384-8
	7C2E (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-		4.2	2020-08-26	doi.org/10.1038/s41422-020-0384-8
	7LLL	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/β1/γ2	3.7	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLL (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-		3.7	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLY	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-	Gs/β1/γ2	3.3	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLY (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-		3.3	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7FIM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7FIM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-	Gs/β1/γ2	3	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-		3	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBH	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-	Gs/β1/γ2	3	2022-04-06	doi.org/10.1038/s41467-022-28683-0
	7VBH (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-		3	2022-04-06	doi.org/10.1038/s41467-022-28683-0
	7S1M	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-	Gs/β1/γ2	2.41	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S1M (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-		2.41	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S3I	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.51	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S3I (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.51	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	6XOX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-	chim(NtGi1-Gs)/β1/γ2	3.1	2020-11-18	doi.org/10.1073/pnas.2014879117
	6XOX (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-		3.1	2020-11-18	doi.org/10.1073/pnas.2014879117
	7RG9	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RG9 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.2	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RGP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	chim(NtGi1-Gs)/β1/γ2	2.9	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RGP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		2.9	2022-04-13	doi.org/10.1073/pnas.2116506119
	7X8R	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-	Gs/β1/γ2	2.61	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8R (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-		2.61	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8S	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-	Gs/β1/γ2	3.09	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8S (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-		3.09	2022-06-29	doi.org/10.1073/pnas.2200155119
	8JIP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-	chim(NtGi1-Gs)/β1/γ2	2.85	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-		2.85	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-	chim(NtGi1-Gs)/β1/γ2	2.57	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-		2.57	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIS	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-	chim(NtGi1-Gs)/β1/γ2	2.46	2023-11-08	doi.org/10.1073/pnas.2303696120
	8JIS (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-		2.46	2023-11-08	doi.org/10.1073/pnas.2303696120
	8YW3	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-	Gs/β1/γ2	2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW3 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-		2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	9EBN	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	3.44	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBN (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.44	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBO	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (ACPC18)	-	Gs/β1/γ2	3.13	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBO (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (ACPC18)	-		3.13	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	3.16	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBQ (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.16	2025-03-26	doi.org/10.1073/pnas.2407574122
	8YWF	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-	chim(NtGi1-Gs)/β1/γ2	2.74	2025-04-16	To be published
	8YWF (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-		2.74	2025-04-16	To be published
	9BYO	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-3	-	Gs/β1/γ2	2.31	2025-06-11	To be published
	9BYO (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-3	-		2.31	2025-06-11	To be published
	9C0K	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/β1/γ2	2.72	2025-06-11	To be published
	9C0K (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-		2.72	2025-06-11	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9EBO_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.