Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:K34 8.0725424
2A:A:Y37 8.2875424
3A:A:T40 6.595407
4A:A:R42 7.088529
5A:A:F212 6.155479
6A:A:F219 7.34678
7A:A:H220 11.6125427
8A:A:F222 10.0375427
9A:A:Q227 5.7475419
10A:A:K233 7.51619
11A:A:W234 5.566519
12A:A:F238 12.4525409
13A:A:F273 8.864589
14A:A:W277 10.62586
15A:A:W281 10.746515
16A:A:L282 6.7525409
17A:A:I288 3.2575409
18A:A:L289 5.025489
19A:A:N292 4.4225409
20A:A:F315 10.0375406
21A:A:P321 7.4075405
22A:A:E330 6.715403
23A:A:V334 6.005404
24A:A:Y339 5.88503
25A:A:F340 13.244507
26A:A:R342 6.59667604
27A:A:C359 4.51485
28A:A:Y360 10.746598
29A:A:F363 8.9525405
30A:A:T364 8.1025439
31A:A:C365 4.685438
32A:A:D368 9.428539
33A:A:F376 8.144578
34A:A:R385 12.85495
35A:A:H387 7.7065238
36A:A:L388 4.234248
37B:B:L14 4.094258
38B:B:I18 5.09833607
39B:B:R22 5.465406
40B:B:D27 8.5675408
41B:B:L30 5.085405
42B:B:H54 8.30143729
43B:B:K57 8.91519
44B:B:Y59 11.414518
45B:B:W63 10.3325407
46B:B:V71 5.294148
47B:B:D76 7.04629
48B:B:K78 7.1525408
49B:B:L79 6.7165147
50B:B:W82 11.3575429
51B:B:D83 11.205428
52B:B:Y85 9.35754264
53B:B:T86 9.355426
54B:B:K89 7.58714729
55B:B:L95 7.03754148
56B:B:W99 11.9429
57B:B:M101 4.7825419
58B:B:Y105 5.36571706
59B:B:I123 4.0425406
60B:B:H142 6.986676159
61B:B:Y145 6.85429718
62B:B:R150 4.9275406
63B:B:F151 5.058509
64B:B:Q156 8.9405
65B:B:I157 4.7275407
66B:B:T159 6.3454159
67B:B:W169 10.765158
68B:B:F180 11.835447
69B:B:H183 8.21333649
70B:B:F199 9.755449
71B:B:C204 4.65417
72B:B:K209 13.74446
73B:B:W211 9.68833648
74B:B:D212 6.78254299
75B:B:R219 8.15254295
76B:B:H225 8.532569
77B:B:D228 7.888519
78B:B:I232 6.105468
79B:B:F235 6.991676166
80B:B:P236 7.0854167
81B:B:F241 6.538566
82B:B:D246 5.565419
83B:B:R251 11.944508
84B:B:D254 5.2025409
85B:B:R256 7.324309
86B:B:D258 9.0575407
87B:B:L261 5.85405
88B:B:Y264 5.55833605
89B:B:H266 8.21454
90B:B:I269 4.1625454
91B:B:F278 6.5285167
92B:B:R283 8.9645139
93B:B:L284 5.805405
94B:B:Y289 9.245657
95B:B:D290 7.088516
96B:B:N295 8.578556
97B:B:W297 7.862558
98B:B:R304 7.15833655
99B:B:V307 3.49553
100B:B:L308 5.655407
101B:B:H311 10.6445319
102B:B:R314 14.836518
103B:B:T321 6.13754277
104B:B:M325 6.5325405
105B:B:W332 14.01619
106B:B:D333 9.48254319
107B:B:W339 8.0225409
108G:G:R27 7.1625408
109G:G:D48 6.368509
110G:G:L51 5.0025406
111G:G:N59 5.785409
112G:G:F61 6.5345268
113R:R:L32 4.365404
114R:R:W33 11.115193
115R:R:W39 14.5475405
116R:R:R40 9.468502
117R:R:Y69 7.75254336
118R:R:C85 3.88254349
119R:R:Y88 10.9945325
120R:R:W91 7.0425404
121R:R:R102 8.0025408
122R:R:Y148 6.2925357
123R:R:Y152 6.8454357
124R:R:F169 11.6954367
125R:R:R176 4.724109
126R:R:N177 4.24509
127R:R:F184 6.285408
128R:R:F187 10.53254218
129R:R:M204 5.5925403
130R:R:F230 6.0385125
131R:R:Q234 5.61754127
132R:R:Y242 6.2945176
133R:R:W243 10.63717209
134R:R:L244 4.3654219
135R:R:L245 4.47254178
136R:R:E247 6.7975409
137R:R:Y250 5.9654108
138R:R:W274 13.63754209
139R:R:W284 6.3685128
140R:R:Y305 8.6925374
141R:R:F324 5.9585389
142R:R:K334 7.078599
143R:R:I357 6.02254388
144R:R:H363 9.19408
145R:R:E364 6.0475408
146R:R:F367 8.385397
147R:R:E412 12.044368
148R:R:R421 5.4054184
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D83 B:B:T86 10015.9YesYes286
2B:B:N88 B:B:T86 1008.77NoYes276
3A:A:N23 B:B:N88 10016.35NoNo277
4A:A:N23 B:B:K89 1008.39NoYes279
5A:A:L30 B:B:K89 86.43585.64NoYes059
6A:A:L30 B:B:K78 86.27754.23NoYes058
7B:B:D76 B:B:K78 85.32988.3YesYes098
8B:B:I80 B:B:K89 86.27285.82NoYes289
9B:B:H54 B:B:I80 86.114513.26YesNo298
10B:B:D76 B:B:H54 1003.78YesYes299
11B:B:K89 B:B:W82 86.435417.4YesYes299
12B:B:H54 B:B:W82 86.11455.29YesYes299
13A:A:Y37 B:B:D76 1004.6YesYes249
14A:A:R42 A:A:Y37 10018.52YesYes294
15A:A:R42 B:B:W99 1004YesYes299
16A:A:F238 B:B:W99 1009.02YesYes099
17A:A:F238 A:A:W234 1005.01YesYes099
18A:A:R231 A:A:W234 1006NoYes099
19A:A:L272 A:A:R231 1007.29NoNo089
20A:A:F246 A:A:L272 1006.09NoNo098
21A:A:F246 A:A:F273 1009.65NoYes099
22A:A:F273 A:A:F345 84.40477.5YesNo098
23A:A:F345 A:A:L289 64.39664.87NoYes089
24A:A:L289 A:A:L291 1005.54YesNo098
25A:A:F363 A:A:L291 1004.87YesNo058
26A:A:F363 A:A:Q294 1004.68YesNo056
27A:A:C365 A:A:Q294 1004.58YesNo386
28A:A:C365 A:A:D368 1003.11YesYes389
29A:A:D368 A:A:T364 1005.78YesYes399
30A:A:F290 A:A:T364 50.09439.08NoYes399
31A:A:F290 A:A:I288 97.32433.77NoYes099
32A:A:I288 A:A:V375 45.8023.07YesNo099
33A:A:I245 A:A:V375 42.93963.07NoNo079
34A:A:I245 A:A:L43 40.07724.28NoNo077
35A:A:F219 A:A:L43 31.48948.53YesNo087
36A:A:C359 A:A:F273 1005.59YesYes859
37A:A:C359 A:A:L289 64.38614.76YesYes859
38A:A:C359 A:A:P361 74.40213.77YesNo855
39A:A:P361 A:A:R342 73.92685.76NoYes054
40A:A:F363 A:A:R342 62.49966.41YesYes054
41A:A:D368 A:A:N371 51.523313.46YesNo399
42A:A:F290 A:A:N371 50.09234.83NoNo399
43A:A:N292 A:A:T364 52.95697.31YesYes099
44A:A:I56 A:A:N292 30.05694.25NoYes079
45A:A:I56 A:A:Q59 28.62564.12NoNo079
46A:A:M60 A:A:Q59 27.19439.52NoNo099
47A:A:F212 A:A:M60 24.33193.73YesNo799
48A:A:F212 A:A:F219 15.745110.72YesYes798
49A:A:N292 A:A:V247 14.31364.43YesNo097
50A:A:K53 A:A:V247 12.88234.55NoNo097
51A:A:N264 A:A:Y311 10.03826.98NoNo096
52A:A:N264 A:A:Q267 11.47185.28NoNo094
53A:A:L270 A:A:Q267 19.09857.99NoNo064
54A:A:F345 A:A:L270 19.576117.05NoNo086
55A:A:F219 A:A:F376 25.76368.57YesYes788
56B:B:D83 B:B:L69 31.39564.07YesNo085
57B:B:L69 B:B:Y105 62.28837.03NoYes056
58B:B:H62 B:B:Y105 56.07374.36NoYes066
59B:B:H62 B:B:R150 55.91877.9NoYes066
60A:A:I288 A:A:I382 45.80322.94YesNo096
61A:A:I382 A:A:Y360 40.07787.25NoYes968
62A:A:F363 A:A:K338 20.043819.85YesNo055
63A:A:E330 A:A:K338 15.74888.1YesNo035
64A:A:E330 A:A:V334 17.18019.98YesYes034
65A:A:Y358 A:A:Y360 11.45097.94NoYes048
66A:A:D381 A:A:Y360 20.039114.94NoYes988
67A:A:D381 R:R:K334 11.45099.68NoYes989
68B:B:D83 B:B:R68 10013.1YesNo085
69B:B:R68 B:B:Y85 10016.46NoYes054
70B:B:Y85 G:G:P60 1005.56YesNo049
71B:B:M325 G:G:P60 1005.03YesNo059
72B:B:M325 G:G:P49 1005.03YesNo057
73G:G:D48 G:G:P49 1004.83YesNo097
74B:B:S279 G:G:D48 1008.83NoYes099
75B:B:L284 B:B:S279 1006.01YesNo059
76B:B:L284 B:B:V296 1005.96YesNo055
77B:B:L308 B:B:V296 1004.47YesNo075
78B:B:C294 B:B:L308 1007.94NoYes057
79B:B:C294 B:B:V315 1005.12NoNo057
80B:B:H311 B:B:V315 1005.54YesNo097
81B:B:D333 B:B:H311 10015.13YesYes3199
82B:B:D312 B:B:D333 1005.32NoYes059
83B:B:D312 R:R:H171 10025.21NoNo057
84R:R:E412 R:R:H171 1007.39YesNo087
85R:R:E412 R:R:L172 1005.3YesNo3689
86R:R:L172 R:R:N177 1005.49NoYes099
87R:R:N177 R:R:R176 41.40574.82YesYes099
88R:R:R176 R:R:Y250 16.20534.12YesYes1098
89R:R:L254 R:R:Y250 12.01357.03NoYes088
90A:A:H387 R:R:L254 11.413420.57YesNo088
91B:B:Y85 G:G:F61 10010.32YesYes2648
92B:B:M325 G:G:F61 1004.98YesYes058
93G:G:D48 G:G:L51 1008.14YesYes096
94B:B:L284 G:G:L51 1005.54YesYes056
95B:B:L308 B:B:W339 1004.56YesYes079
96B:B:T329 B:B:W339 10012.13NoYes089
97B:B:H311 B:B:T329 1008.21YesNo098
98B:B:K337 B:B:W339 1008.12NoYes069
99B:B:H311 B:B:K337 10011.79YesNo096
100B:B:D312 R:R:K415 1004.15NoNo057
101R:R:E412 R:R:K415 10012.15YesNo087
102A:A:Y391 R:R:R176 17.39824.12NoYes1049
103A:A:Y391 R:R:L251 16.80018.21NoNo049
104R:R:L251 R:R:V327 16.20012.98NoNo099
105A:A:L388 R:R:L255 14.41424.15YesNo088
106A:A:L388 A:A:L394 12.01764.15YesNo2488
107A:A:L394 R:R:L335 10.81594.15NoNo088
108B:B:C148 B:B:R150 49.33594.18NoYes066
109B:B:C148 B:B:L190 49.17384.76NoNo065
110B:B:L190 B:B:S160 49.01177.51NoNo056
111B:B:S160 B:B:V187 48.84964.85NoNo069
112B:B:H183 B:B:V187 24.91754.15YesNo499
113B:B:H183 B:B:W211 23.61034.23YesYes498
114B:B:F180 B:B:W211 45.58120.04YesYes478
115B:B:F180 B:B:T178 44.92847.78YesNo074
116B:B:T177 B:B:T178 44.60134.71NoNo044
117B:B:L168 B:B:T177 44.27414.42NoNo064
118B:B:L168 B:B:V213 40.02025.96NoNo064
119B:B:R214 B:B:V213 39.69287.85NoNo094
120B:B:D212 B:B:R214 39.03823.57YesNo099
121B:B:D212 B:B:R219 34.119114.29YesYes2995
122B:B:L210 B:B:R219 30.19073.64NoYes055
123B:B:L210 B:B:Q220 29.53543.99NoNo057
124B:B:D258 B:B:Q220 19.70111.75YesNo077
125B:B:I18 B:B:L14 13.79192.85YesYes078
126B:B:S201 B:B:V187 23.76996.46NoNo499
127B:B:S201 B:B:W211 23.60693.71NoYes498
128B:B:D66 B:B:R68 31.133211.91NoNo085
129B:B:D66 B:B:L69 31.058612.21NoNo085
130R:R:H180 R:R:N177 1003.83NoYes099
131R:R:E247 R:R:H180 10011.08YesNo099
132R:R:E247 R:R:L183 56.38233.98YesNo099
133R:R:F187 R:R:L183 50.98516.09YesNo2189
134R:R:F187 R:R:Q394 46.79268.2YesNo089
135R:R:H363 R:R:Q394 46.19356.18YesNo089
136R:R:E364 R:R:H363 20.4024.92YesYes088
137R:R:E364 R:R:F367 18.60258.16YesYes087
138R:R:E387 R:R:F367 34.805612.83NoYes087
139R:R:E387 R:R:L388 33.60563.98NoNo087
140R:R:L388 R:R:Y148 28.80537.03NoYes077
141R:R:F390 R:R:H363 23.402320.36NoYes068
142R:R:F367 R:R:F390 18.6024.29YesNo3976
143R:R:E247 R:R:L359 97.12515.3YesNo099
144R:R:L359 R:R:L360 1004.15NoNo099
145R:R:L360 R:R:N320 1008.24NoNo099
146R:R:L245 R:R:N320 1005.49YesNo089
147R:R:L245 R:R:Y242 1004.69YesYes1786
148R:R:F280 R:R:Y242 10010.32NoYes1756
149R:R:F280 R:R:I309 1003.77NoNo057
150R:R:I309 R:R:Q234 1008.23NoYes077
151R:R:F230 R:R:Q234 1004.68YesYes1257
152R:R:F230 R:R:T298 1009.08YesNo1255
153R:R:C296 R:R:T298 1001.69NoNo095
154R:R:C296 R:R:G295 1001.96NoNo094
155R:R:G295 R:R:W33 1005.63NoYes043
156R:R:H180 R:R:Y402 1005.44NoNo098
157R:R:L359 R:R:Y402 97.005323.45NoNo098
158R:R:Q37 R:R:W33 10021.9NoYes1943
159R:R:E41 R:R:Q37 1003.82NoNo044
160R:R:E41 R:R:R44 1005.82NoNo043
161R:R:R40 R:R:R44 1004.26YesNo023
162R:R:R40 R:R:W39 1009YesYes025
163R:R:W39 R:R:Y88 49.159327.01YesYes055
164R:R:T35 R:R:Y88 32.37533.75NoYes3255
165R:R:T35 R:R:W214 31.17657.28NoNo051
166R:R:L32 R:R:W214 28.77863.42YesNo041
167R:R:L32 R:R:M204 16.78834.24YesYes043
168R:R:W39 R:R:Y42 21.581615.43YesNo056
169R:R:W39 R:R:Y69 35.96916.75YesYes056
170R:R:C71 R:R:Y42 19.186614.79NoNo096
171R:R:C46 R:R:C71 17.98757.28NoNo089
172R:R:C46 R:R:S49 16.78843.44NoNo082
173R:R:D74 R:R:S49 15.589310.31NoNo032
174R:R:D53 R:R:D74 10.792815.97NoNo033
175R:R:D67 R:R:Y69 32.372412.64NoYes3396
176R:R:D67 R:R:W72 31.17635.58NoNo099
177R:R:T65 R:R:W72 21.58457.28NoNo059
178R:R:L109 R:R:T65 20.38545.9NoNo055
179R:R:L109 R:R:P119 14.39016.57NoNo056
180R:R:L118 R:R:P119 13.1911.64NoNo046
181R:R:L118 R:R:S116 11.99196.01NoNo045
182R:R:D114 R:R:S116 10.79275.89NoNo045
183R:R:P86 R:R:Y88 11.99194.17NoYes085
184R:R:C85 R:R:P86 10.79281.88YesNo098
185R:R:Y148 R:R:Y152 18.004110.92YesYes3577
186R:R:S392 R:R:Y152 14.40355.09NoYes097
187R:R:F393 R:R:S392 13.20335.28NoNo079
188R:R:F393 R:R:G151 12.00316.02NoNo078
189R:R:G151 R:R:V150 10.80281.84NoNo085
190R:R:L166 R:R:N177 10.22355.49NoYes089
191R:R:E247 R:R:I179 12.01056.83YesNo098
192R:R:I179 R:R:W243 11.41044.7NoYes089
193R:R:Q234 R:R:W284 23.96935.48YesYes1278
194R:R:K288 R:R:W284 16.788715.08NoYes088
195R:R:G248 R:R:L360 13.1913.42NoNo089
196R:R:G248 R:R:I323 11.99193.53NoNo088
197A:A:Q19 B:B:N88 10011.88NoNo247
198A:A:Q19 B:B:D83 10011.75NoYes248
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:C347 W:W:?1 33.57 0 No No 7 0 1 0
R:R:C347 R:R:D344 1.56 0 No No 7 7 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
50.00Single7E14PubChem 1560227387E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
50.00Single7EVMPubChem 1560227387EVM-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
25.00Single7DUQPubChem 1560227387DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
12.50Single5VEXNNC06405VEX-GLP-1-NNC0640
12.50Single6KK7PubChem 681786306KK7-GLP-1-PubChem 68178630
11.11Single6KJVPubChem 681786306KJV-GLP-1-PubChem 68178630
10.00Single5VEWPF-063722225VEW-GLP-1-PF-06372222
9.09Single5XEZNNC06405XEZ-Glucagon-NNC0640
8.33Single5XF1NNC06405XF1-Glucagon-NNC0640
7.69Single6LN2PubChem 681786306LN2-GLP-1-PubChem 68178630

PDB Summary
PDB 7DUR
Class B1
SubFamily Peptide
Type Glucagon
SubType GLP-1
Species Homo sapiens
Ligand -
Other Ligand(s) PubChem 156022738
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 3.3
Date 2021-08-11
D.O.I. 10.1038/s41467-021-24058-z
Net Summary
Imin 3.71
Number of Linked Nodes 952
Number of Links 1092
Number of Hubs 148
Number of Links mediated by Hubs 560
Number of Communities 40
Number of Nodes involved in Communities 220
Number of Links involved in Communities 283
Path Summary
Number Of Nodes in MetaPath 199
Number Of Links MetaPath 198
Number of Shortest Paths 55997414
Length Of Smallest Path 3
Average Path Length 128
Length of Longest Path 89
Minimum Path Strength 1.305
Average Path Strength 16
Maximum Path Strength 28.44
Minimum Path Correlation 0.7
Average Path Correlation 1
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.69492
Average % Of Corr. Nodes 71.6494
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 64.7074
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeHNO
PDB ResiduesW:W:?1
Environment DetailsOpen EMBL-EBI Page
CodeHNO
NameN-tert-butyl-6,7-bis(chloranyl)quinoxalin-2-amine
Synonyms
Identifier~{N}-~{tert}-butyl-6,7-bis(chloranyl)quinoxalin-2-amine
FormulaC12 H13 Cl2 N3
Molecular Weight270.158
SMILESCC(C)(C)Nc1cnc2cc(c(cc2n1)Cl)Cl
PubChem156022738
Formal Charge0
Total Atoms30
Total Chiral Atoms0
Total Bonds31
Total Aromatic Bonds11

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7DUR_Chain_A
DQRNEEKAQ REANKKIEK QLQKDKQVY RATHRLLLL GAGESGKNT 
IVKQMRILH IFETKFQVD KVNFHMFDV GAQRDERRK WIQCFNDVT 
AIIFVVASS SYNQTNRLQ AALKLFDSI WNNKWLRDT SVILFLNKQ 
DLLAEKVLA GKSKIEDYF PEFARYTTP EDATPEPGE DPRVTRAKY 
FIRDEFLRI STASGDGRH YCYPHFTCA VDTENIRRV FNDCRDIIQ 
RMHLRQYEL L


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP54311
Sequence
>7DUR_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP63212
Sequence
>7DUR_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP FR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP43220
Sequence
>7DUR_Chain_R
TVSLWETVQ KWREYRRQC QRSLTEDPP PFCNRTFDE YACWPDGEP 
GSFVNVSCP WYLPWASSV PQGHVYRFC TAEGLWLQK DNSSLPWRD 
LSECEESPE EQLLFLYII YTVGYALSF SALVIASAI LLGFRHLHC 
TRNYIHLNL FASFILRAL SVFIKDAAL KWMYSTAAQ QHQWDGLLS 
YQDSLSCRL VFLLMQYCV AANYYWLLV EGVYLYTLL AFSVLSEQW 
IFRLYVSIG WGVPLLFVV PWGIVKYLY EDEGCWTRN SNMNYWLII 
RLPILFAIG VNFLIFVRV ICIVVSKLK ANLTDIKCR LAKSTLTLI 
PLLGTHEVI FARFIKLFT ELSFTSFQG LMVAILYCF VNNEVQLEF 
RKSWERWRL EH


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5NX2B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)--3.72017-06-1410.1038/nature22800
5VAIB1PeptideGlucagonGLP-1Oryctolagus cuniculusGLP-1-Gs/&β;1/&γ;24.12017-05-2410.1038/nature22394
5VEWB1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-2.72017-05-2410.1038/nature22378
5VEXB1PeptideGlucagonGLP-1Homo sapiens-NNC0640-32017-05-1710.1038/nature22378
6B3JB1PeptideGlucagonGLP-1Homo sapiensExendin-P5-Gs/&β;1/&γ;23.32018-02-2110.1038/nature25773
6KJVB1PeptideGlucagonGLP-1Homo sapiens-PubChem 68178630-2.82019-11-1310.1107/S2052252519013496
6KK1B1PeptideGlucagonGLP-1Homo sapiens-PubChem 68178630-2.82019-11-1310.1107/S2052252519013496
6KK7B1PeptideGlucagonGLP-1Homo sapiens-PubChem 68178630-3.12019-11-1310.1107/S2052252519013496
6LN2B1PeptideGlucagonGLP-1Homo sapiens-PubChem 68178630-3.22020-03-1810.1038/s41467-020-14934-5
6ORVB1PeptideGlucagonGLP-1Homo sapiens-TT-OAD2Gs/&β;1/&γ;232020-01-0810.1038/s41586-019-1902-z
6VCBB1PeptideGlucagonGLP-1Homo sapiensGLP-1LSN3160440Gs/&β;1/&γ;23.32020-07-2210.1038/s41589-020-0589-7
6X18B1PeptideGlucagonGLP-1Homo sapiensGLP-1-Gs/&β;1/&γ;22.12020-09-0910.1016/j.molcel.2020.09.020
6X19B1PeptideGlucagonGLP-1Homo sapiensCHU-128-Gs/&β;1/&γ;22.12020-09-0910.1016/j.molcel.2020.09.020
6X1AB1PeptideGlucagonGLP-1Homo sapiensDanuglipron-Gs/&β;1/&γ;22.52020-09-0910.1016/j.molcel.2020.09.020
6XOXB1PeptideGlucagonGLP-1Homo sapiensOrforglipron-chim(NtGi1-Gs)/&β;1/&γ;23.12020-11-1810.1073/pnas.2014879117
7C2EB1PeptideGlucagonGLP-1Homo sapiensPubChem 149050799-Gs/&β;1/&γ;24.22020-08-2610.1038/s41422-020-0384-8
7DUQB1PeptideGlucagonGLP-1Homo sapiensGLP-1PubChem 156022738Gs/&β;1/&γ;22.52021-07-1410.1038/s41467-021-24058-z
7DURB1PeptideGlucagonGLP-1Homo sapiens-PubChem 156022738Gs/&β;1/&γ;23.32021-08-1110.1038/s41467-021-24058-z
7E14B1PeptideGlucagonGLP-1Homo sapiensOrforglipronPubChem 156022738Gs/&β;1/&γ;22.92021-07-0710.1038/s41467-021-24058-z
7EVMB1PeptideGlucagonGLP-1Homo sapiens-PubChem 156022738Gs/&β;1/&γ;22.52021-08-1110.1038/s41467-021-24058-z
7FIMB1PeptideGlucagonGLP-1Homo sapiensTirzepatide-Gs/&β;1/&γ;23.42022-03-0210.1038/s41467-022-28683-0
7KI0B1PeptideGlucagonGLP-1Homo sapiensSemaglutide-Gs/&β;1/&γ;22.52021-08-0410.1016/j.celrep.2021.109374
7KI1B1PeptideGlucagonGLP-1Homo sapiensTaspoglutide-Gs/&β;1/&γ;22.52021-08-0410.1016/j.celrep.2021.109374
7LCIB1PeptideGlucagonGLP-1Homo sapiensDanuglipron-Gs/&β;1/&γ;22.92021-01-2010.1016/j.str.2021.04.008
7LCJB1PeptideGlucagonGLP-1Homo sapiensDanuglipron--2.822021-01-2010.1016/j.str.2021.04.008
7LCKB1PeptideGlucagonGLP-1Homo sapiensDanuglipron--3.242021-01-2010.1016/j.str.2021.04.008
7LLLB1PeptideGlucagonGLP-1Homo sapiensExendin-4-Gs/&β;1/&γ;23.72022-01-1210.1038/s41467-021-27760-0
7LLYB1PeptideGlucagonGLP-1Homo sapiensOxyntomodulin-Gs/&β;1/&γ;23.32022-01-1210.1038/s41467-021-27760-0
7RG9B1PeptideGlucagonGLP-1Homo sapiens--chim(NtGi1-Gs)/&β;1/&γ;23.22022-04-1310.1073/pnas.2116506119
7RGPB1PeptideGlucagonGLP-1Homo sapiensTirzepatide-chim(NtGi1-Gs)/&β;1/&γ;22.92022-04-1310.1073/pnas.2116506119
7RTBB1PeptideGlucagonGLP-1Homo sapiensPeptide-19-Gs/&β;1/&γ;22.142021-10-0610.1016/j.bbrc.2021.09.016
7S15B1PeptideGlucagonGLP-1Homo sapiensPubChem 134611223--3.82022-06-0810.1021/acs.jmedchem.1c01856
7S1MB1PeptideGlucagonGLP-1Homo sapiensEx4-D-Ala-Gs/&β;1/&γ;22.412022-01-0510.1038/s41589-021-00945-w
7S3IB1PeptideGlucagonGLP-1Homo sapiens--Gs/&β;1/&γ;22.512022-01-0510.1038/s41589-021-00945-w
7VBHB1PeptideGlucagonGLP-1Homo sapiensPeptide-20-Gs/&β;1/&γ;232022-04-0610.1038/s41467-022-28683-0
7VBIB1PeptideGlucagonGLP-1Homo sapiensNon-Acylated Tirzepatide-Gs/&β;1/&γ;232022-03-0210.1038/s41467-022-28683-0
7X8RB1PeptideGlucagonGLP-1Homo sapiensBOC5-Gs/&β;1/&γ;22.612022-06-2910.1073/pnas.2200155119
7X8SB1PeptideGlucagonGLP-1Homo sapiensWB4-24-Gs/&β;1/&γ;23.092022-06-2910.1073/pnas.2200155119
8JIPB1PeptideGlucagonGLP-1Homo sapiensMEDI0382-chim(NtGi1-Gs)/&β;1/&γ;22.852023-09-0610.1073/pnas.2303696120
8JIRB1PeptideGlucagonGLP-1Homo sapiensSAR425899-chim(NtGi1-Gs)/&β;1/&γ;22.572023-09-0610.1073/pnas.2303696120
8JISB1PeptideGlucagonGLP-1Homo sapiensPeptide-15-chim(NtGi1-Gs)/&β;1/&γ;22.462023-11-0810.1073/pnas.2303696120
8WG7B1PeptideGlucagonGLP-1Homo sapiens--Gs/&β;1/&γ;22.542024-03-0610.1038/s41421-024-00649-0




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