psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E34	R:R:S31	8.62	No	No	0	4	4
2	L:L:E21	R:R:S31	7.19	No	No	0	0	4
3	R:R:L32	R:R:Q213	6.65	No	No	0	4	4
4	R:R:Q37	R:R:W33	16.43	No	No	0	4	3
5	R:R:P90	R:R:T35	6.99	Yes	No	0	4	5
6	L:L:F28	R:R:V36	11.8	Yes	No	0	0	2
7	R:R:Q37	R:R:R40	10.51	No	No	0	4	2
8	R:R:K38	R:R:W87	10.44	No	Yes	0	4	3
9	R:R:R43	R:R:W39	6	No	Yes	0	4	5
10	R:R:W39	R:R:Y88	6.75	Yes	Yes	2	5	5
11	L:L:F28	R:R:W39	6.01	Yes	Yes	2	0	5
12	L:L:L32	R:R:W39	10.25	No	Yes	2	0	5
13	L:L:R36	R:R:W39	5	Yes	Yes	0	0	5
14	R:R:R40	R:R:R43	5.33	No	No	0	2	4
15	R:R:E41	R:R:R44	13.96	No	No	0	4	3
16	R:R:C46	R:R:Y42	5.38	No	Yes	2	8	6
17	R:R:F66	R:R:Y42	3.09	No	Yes	0	7	6
18	R:R:C71	R:R:Y42	6.72	No	Yes	2	9	6
19	R:R:W87	R:R:Y42	8.68	Yes	Yes	0	3	6
20	R:R:Y42	R:R:Y88	14.89	Yes	Yes	2	6	5
21	R:R:R44	R:R:R48	6.4	No	No	0	3	4
22	R:R:C46	R:R:C71	7.28	No	No	2	8	9
23	R:R:D53	R:R:S49	10.31	No	No	0	3	2
24	R:R:L50	R:R:R64	4.86	No	No	0	4	4
25	R:R:D53	R:R:P54	4.83	No	No	0	3	2
26	R:R:D53	R:R:R64	14.29	No	No	0	3	4
27	R:R:F61	R:R:P56	11.56	No	Yes	9	3	1
28	R:R:D74	R:R:P56	12.88	No	Yes	9	3	1
29	R:R:L60	R:R:P77	11.49	No	No	0	1	4
30	R:R:F61	R:R:N63	6.04	No	No	0	3	4
31	R:R:D74	R:R:F61	4.78	No	No	9	3	3
32	R:R:C104	R:R:C62	7.28	No	No	0	9	9
33	R:R:C62	R:R:W110	11.75	No	No	0	9	9
34	R:R:D74	R:R:R64	22.63	No	No	0	3	4
35	R:R:E68	R:R:F66	5.83	No	No	0	4	7
36	R:R:D67	R:R:W72	7.82	No	Yes	0	9	9
37	R:R:D67	R:R:R121	3.57	No	No	0	9	6
38	L:L:R36	R:R:E68	13.96	Yes	No	0	0	4
39	R:R:P86	R:R:Y69	9.74	Yes	Yes	2	8	6
40	R:R:Y69	R:R:Y88	5.96	Yes	Yes	2	6	5
41	R:R:L89	R:R:Y69	7.03	Yes	Yes	2	5	6
42	R:R:L123	R:R:Y69	9.38	No	Yes	2	5	6
43	R:R:A70	R:R:W72	5.19	No	Yes	0	5	9
44	R:R:V81	R:R:W72	3.68	No	Yes	0	6	9
45	R:R:V83	R:R:W72	7.36	No	Yes	10	5	9
46	R:R:V100	R:R:W72	6.13	No	Yes	10	7	9
47	R:R:R102	R:R:W72	39.98	Yes	Yes	0	8	9
48	R:R:E76	R:R:S79	8.62	No	No	0	1	5
49	R:R:F103	R:R:G78	6.02	Yes	No	0	4	7
50	R:R:F103	R:R:F80	24.65	Yes	No	0	4	4
51	R:R:F80	R:R:W120	5.01	No	No	0	4	5
52	R:R:H99	R:R:N82	3.83	No	No	4	4	4
53	R:R:N82	R:R:Y101	9.3	No	Yes	4	4	5
54	R:R:V100	R:R:V83	3.21	No	No	10	7	5
55	R:R:C85	R:R:P86	3.77	No	Yes	0	9	8
56	R:R:C126	R:R:C85	7.28	No	No	0	9	9
57	R:R:P86	R:R:Y88	9.74	Yes	Yes	2	8	5
58	R:R:L89	R:R:P86	9.85	Yes	Yes	2	5	8
59	R:R:L89	R:R:Y88	5.86	Yes	Yes	2	5	5
60	L:L:L32	R:R:Y88	3.52	No	Yes	2	0	5
61	R:R:L89	R:R:P90	3.28	Yes	Yes	2	5	4
62	R:R:L89	R:R:W91	3.42	Yes	Yes	2	5	4
63	L:L:I29	R:R:L89	4.28	No	Yes	2	0	5
64	R:R:P90	R:R:W91	13.51	Yes	Yes	2	4	4
65	L:L:I29	R:R:P90	6.77	No	Yes	2	0	4
66	R:R:E128	R:R:W91	16.36	No	Yes	0	3	4
67	L:L:I29	R:R:W91	9.4	No	Yes	2	0	4
68	R:R:S94	R:R:V95	3.23	No	No	0	4	5
69	R:R:P96	R:R:V95	3.53	No	No	0	3	5
70	R:R:G98	R:R:H99	3.18	No	No	0	4	4
71	R:R:H99	R:R:Y101	9.8	No	Yes	4	4	5
72	R:R:C126	R:R:V100	3.42	No	No	0	9	7
73	R:R:D122	R:R:Y101	6.9	Yes	Yes	4	7	5
74	R:R:E125	R:R:Y101	11.22	No	Yes	4	5	5
75	R:R:R102	R:R:W110	23.99	Yes	No	0	8	9
76	R:R:F103	R:R:T105	16.86	Yes	No	11	4	4
77	R:R:F103	R:R:L111	4.87	Yes	No	11	4	4
78	R:R:L111	R:R:T105	5.9	No	No	11	4	4
79	R:R:L111	R:R:W120	7.97	No	No	0	4	5
80	R:R:P119	R:R:Q112	3.16	No	No	0	6	3
81	R:R:L118	R:R:P119	3.28	No	No	0	4	6
82	R:R:D122	R:R:W120	3.35	Yes	No	0	7	5
83	R:R:L123	R:R:R121	10.93	No	No	2	5	6
84	L:L:V33	R:R:R121	5.23	No	No	2	0	6
85	R:R:D122	R:R:S124	5.89	Yes	No	4	7	5
86	R:R:D122	R:R:E125	10.39	Yes	No	4	7	5
87	L:L:V33	R:R:L123	4.47	No	No	2	0	5
88	R:R:E125	R:R:S124	4.31	No	No	4	5	5
89	R:R:P137	R:R:Q140	12.63	No	No	0	3	4
90	L:L:Y19	R:R:E138	13.47	No	No	0	0	2
91	L:L:?37	R:R:E138	3.07	Yes	No	0	0	2
92	R:R:F381	R:R:Q140	10.54	Yes	No	0	4	4
93	L:L:F12	R:R:L141	6.09	Yes	No	1	0	5
94	L:L:V16	R:R:L141	5.96	No	No	1	0	5
95	R:R:I146	R:R:L142	4.28	No	No	0	4	3
96	R:R:F143	R:R:I147	8.79	No	No	0	4	6
97	R:R:F143	R:R:F381	3.22	No	Yes	0	4	4
98	R:R:F143	R:R:F385	4.29	No	No	0	4	6
99	R:R:F381	R:R:L144	3.65	Yes	Yes	0	4	6
100	R:R:L144	R:R:L384	4.15	Yes	No	0	6	5
101	R:R:L144	R:R:L388	4.15	Yes	Yes	1	6	7
102	L:L:F12	R:R:L144	6.09	Yes	Yes	1	0	6
103	R:R:I146	R:R:Y145	3.63	No	Yes	0	4	5
104	R:R:Y145	R:R:Y148	8.94	Yes	Yes	1	5	7
105	R:R:T149	R:R:Y145	9.99	No	Yes	0	7	5
106	R:R:D198	R:R:Y145	10.34	Yes	Yes	1	7	5
107	R:R:I147	R:R:S389	3.1	No	No	0	6	5
108	R:R:D198	R:R:Y148	6.9	Yes	Yes	1	7	7
109	R:R:L388	R:R:Y148	3.52	Yes	Yes	1	7	7
110	L:L:F12	R:R:Y148	8.25	Yes	Yes	1	0	7
111	R:R:G151	R:R:S392	3.71	No	No	1	8	9
112	R:R:F393	R:R:G151	9.03	No	No	1	7	8
113	R:R:R190	R:R:Y152	8.23	Yes	Yes	1	8	7
114	R:R:A191	R:R:Y152	5.34	No	Yes	0	7	7
115	R:R:V194	R:R:Y152	10.09	No	Yes	0	7	7
116	R:R:S392	R:R:Y152	6.36	No	Yes	1	9	7
117	L:L:E9	R:R:Y152	6.73	Yes	Yes	1	0	7
118	R:R:G395	R:R:S155	3.71	No	No	0	9	9
119	R:R:F156	R:R:L192	8.53	No	No	0	7	3
120	R:R:F184	R:R:L159	6.09	No	Yes	0	8	9
121	R:R:G395	R:R:L159	3.42	No	Yes	0	9	9
122	R:R:A399	R:R:L159	3.15	No	Yes	0	8	9
123	R:R:I188	R:R:V160	3.07	No	No	0	7	3
124	R:R:A162	R:R:C403	3.61	No	No	0	9	9
125	R:R:C403	R:R:I165	6.55	No	No	0	9	8
126	R:R:F413	R:R:I165	10.05	No	No	0	5	8
127	R:R:L166	R:R:N177	5.49	No	No	0	8	9
128	R:R:L166	R:R:L181	6.92	No	No	0	8	6
129	R:R:F184	R:R:L166	4.87	No	No	0	8	8
130	R:R:L167	R:R:L181	5.54	No	No	0	3	6
131	R:R:F169	R:R:L172	7.31	No	No	6	7	9
132	R:R:E412	R:R:F169	11.66	Yes	No	6	8	7
133	R:R:F169	R:R:F413	10.72	No	No	0	7	5
134	R:R:H173	R:R:R170	5.64	No	No	0	7	8
135	R:R:E412	R:R:H171	12.31	Yes	No	6	8	7
136	R:R:H171	R:R:K415	3.93	No	Yes	6	7	7
137	R:R:E408	R:R:L172	5.3	No	No	0	9	9
138	R:R:E412	R:R:L172	3.98	Yes	No	6	8	9
139	R:R:H173	R:R:Y178	8.71	No	No	0	7	6
140	R:R:C174	R:R:R176	4.18	No	Yes	3	8	9
141	R:R:C174	R:R:N177	6.3	No	No	3	8	9
142	R:R:T175	R:R:Y250	6.24	No	Yes	0	7	8
143	R:R:E262	R:R:T175	11.29	No	No	0	6	7
144	R:R:N177	R:R:R176	6.03	No	Yes	3	9	9
145	R:R:H180	R:R:R176	5.64	Yes	Yes	3	9	9
146	R:R:R176	R:R:Y250	3.09	Yes	Yes	0	9	8
147	R:R:E408	R:R:R176	3.49	No	Yes	0	9	9
148	R:R:F266	R:R:Y178	5.16	No	No	0	6	6
149	R:R:I179	R:R:V246	3.07	Yes	Yes	0	8	8
150	R:R:E247	R:R:I179	6.83	Yes	Yes	0	9	8
151	R:R:I179	R:R:Y250	7.25	Yes	Yes	0	8	8
152	R:R:E247	R:R:H180	16	Yes	Yes	3	9	9
153	R:R:H180	R:R:L359	3.86	Yes	No	3	9	9
154	R:R:H180	R:R:Y402	5.44	Yes	No	3	9	8
155	R:R:N182	R:R:W243	15.82	No	Yes	13	9	9
156	R:R:N182	R:R:W274	5.65	No	No	13	9	9
157	R:R:F187	R:R:L183	6.09	Yes	No	0	8	9
158	R:R:L183	R:R:L244	4.15	No	No	0	9	9
159	R:R:E247	R:R:L183	11.93	Yes	No	0	9	9
160	R:R:F184	R:R:V398	3.93	No	No	0	8	9
161	R:R:N240	R:R:S186	5.96	No	No	0	9	9
162	R:R:S186	R:R:W243	7.41	No	Yes	0	9	9
163	R:R:F187	R:R:N240	18.12	Yes	No	0	8	9
164	R:R:F187	R:R:Q394	10.54	Yes	Yes	0	8	9
165	R:R:F187	R:R:G395	9.03	Yes	No	0	8	9
166	R:R:F187	R:R:V398	3.93	Yes	No	0	8	9
167	R:R:C236	R:R:L189	6.35	No	No	0	5	7
168	R:R:R190	R:R:V237	6.54	Yes	No	0	8	6
169	R:R:N240	R:R:R190	10.85	No	Yes	0	9	8
170	R:R:R190	R:R:Y241	12.35	Yes	Yes	1	8	8
171	L:L:E9	R:R:R190	11.63	Yes	Yes	1	0	8
172	R:R:L232	R:R:S193	4.5	No	No	14	5	6
173	R:R:M233	R:R:S193	3.07	No	No	0	6	6
174	R:R:C236	R:R:S193	6.89	No	No	14	5	6
175	R:R:D198	R:R:V194	4.38	Yes	No	0	7	7
176	R:R:D198	R:R:K197	4.15	Yes	Yes	0	7	6
177	R:R:F230	R:R:K197	6.2	Yes	Yes	0	5	6
178	R:R:K197	R:R:M233	10.08	Yes	No	0	6	6
179	L:L:T13	R:R:K197	13.51	No	Yes	0	0	6
180	R:R:A199	R:R:W203	3.89	No	No	0	3	3
181	R:R:F230	R:R:L201	4.87	Yes	No	0	5	7
182	L:L:T13	R:R:L201	4.42	No	No	0	0	7
183	R:R:K202	R:R:W203	8.12	No	No	0	4	3
184	R:R:W203	R:R:Y220	7.72	No	No	0	3	3
185	R:R:M204	R:R:Y205	9.58	Yes	Yes	5	3	3
186	R:R:M204	R:R:Q221	10.88	Yes	No	5	3	4
187	R:R:C296	R:R:M204	6.48	No	Yes	0	9	3
188	R:R:M204	R:R:T298	4.52	Yes	Yes	5	3	5
189	R:R:Q221	R:R:Y205	5.64	No	Yes	5	4	3
190	R:R:R299	R:R:Y205	4.12	Yes	Yes	5	4	3
191	L:L:S17	R:R:Y205	5.09	No	Yes	5	0	3
192	L:L:L20	R:R:Y205	14.07	No	Yes	0	0	3
193	R:R:A209	R:R:S206	3.42	No	No	0	1	4
194	R:R:Q210	R:R:W214	6.57	No	Yes	0	4	1
195	L:L:A24	R:R:Q210	4.55	No	No	0	0	4
196	R:R:D215	R:R:Q211	5.22	No	No	0	3	4
197	R:R:Q213	R:R:S219	8.66	No	No	0	4	5
198	R:R:Q213	R:R:Q221	6.4	No	No	0	4	4
199	L:L:F28	R:R:W214	14.03	Yes	Yes	2	0	1
200	L:L:W31	R:R:W214	24.37	Yes	Yes	2	0	1
201	R:R:D222	R:R:L218	17.64	No	No	0	6	3
202	R:R:S225	R:R:Y220	6.36	No	No	0	3	3
203	R:R:C226	R:R:Y220	4.03	No	No	0	9	3
204	R:R:S223	R:R:S225	3.26	No	No	0	4	3
205	R:R:C226	R:R:C296	7.28	No	No	0	9	9
206	R:R:D293	R:R:R227	13.1	No	No	8	7	8
207	R:R:R227	R:R:W297	13.99	No	Yes	8	8	8
208	R:R:F230	R:R:V229	3.93	Yes	No	0	5	7
209	R:R:F230	R:R:T298	7.78	Yes	Yes	0	5	5
210	R:R:C236	R:R:L232	3.17	No	No	14	5	5
211	R:R:Q234	R:R:W284	6.57	Yes	Yes	1	7	8
212	R:R:Q234	R:R:W306	3.29	Yes	Yes	1	7	6
213	R:R:I309	R:R:Q234	4.12	Yes	Yes	1	7	7
214	L:L:H7	R:R:Q234	8.65	Yes	Yes	1	0	7
215	R:R:A239	R:R:Y235	4	No	No	0	8	9
216	R:R:W274	R:R:Y235	7.72	No	No	0	9	9
217	R:R:L278	R:R:Y235	5.86	No	No	0	3	9
218	L:L:H7	R:R:V237	15.22	Yes	No	0	0	6
219	R:R:A238	R:R:I313	3.25	No	No	0	6	7
220	R:R:I313	R:R:Y241	10.88	No	Yes	0	7	8
221	R:R:I317	R:R:Y241	4.84	Yes	Yes	1	7	8
222	R:R:E364	R:R:Y241	6.73	Yes	Yes	1	8	8
223	R:R:V276	R:R:Y242	7.57	Yes	Yes	15	3	6
224	R:R:P277	R:R:Y242	5.56	No	Yes	15	9	6
225	R:R:F280	R:R:Y242	5.16	No	Yes	0	5	6
226	R:R:A316	R:R:Y242	4	No	Yes	0	7	6
227	R:R:V246	R:R:W243	6.13	Yes	Yes	0	8	9
228	R:R:G273	R:R:W243	8.44	No	Yes	0	9	9
229	R:R:W243	R:R:W274	22.49	Yes	No	13	9	9
230	R:R:L244	R:R:Q394	5.32	No	Yes	0	9	9
231	R:R:A316	R:R:L245	3.15	No	No	0	7	8
232	R:R:L245	R:R:N320	9.61	No	No	0	8	9
233	R:R:V246	R:R:Y269	5.05	Yes	Yes	0	8	7
234	R:R:I272	R:R:V246	3.07	No	Yes	0	6	8
235	R:R:E247	R:R:L359	10.6	Yes	No	3	9	9
236	R:R:G248	R:R:I323	3.53	No	No	0	8	8
237	R:R:V249	R:R:Y269	3.79	No	Yes	0	6	7
238	R:R:L254	R:R:Y250	14.07	No	Yes	0	8	8
239	R:R:Y250	R:R:Y269	9.93	Yes	Yes	0	8	7
240	R:R:L251	R:R:L255	4.15	No	No	0	9	8
241	R:R:L251	R:R:V327	4.47	No	No	0	9	9
242	R:R:I323	R:R:Y252	6.04	No	No	0	8	8
243	R:R:R326	R:R:Y252	3.09	No	No	0	8	8
244	R:R:F260	R:R:T253	9.08	No	No	0	7	7
245	R:R:T253	R:R:Y269	3.75	No	Yes	0	7	7
246	R:R:A256	R:R:S258	3.42	No	No	0	6	7
247	R:R:F260	R:R:I265	12.56	No	No	0	7	5
248	R:R:Q263	R:R:R267	7.01	No	No	0	5	4
249	R:R:I265	R:R:Y269	10.88	No	Yes	0	5	7
250	R:R:F266	R:R:V270	5.24	No	No	0	6	5
251	R:R:I272	R:R:L268	7.14	No	No	0	6	2
252	R:R:I272	R:R:V276	4.61	No	Yes	0	6	3
253	R:R:P277	R:R:V276	3.53	No	Yes	15	9	3
254	R:R:L279	R:R:V276	4.47	No	Yes	0	4	3
255	R:R:F280	R:R:P312	18.78	No	No	0	5	8
256	R:R:I309	R:R:V281	3.07	Yes	No	0	7	6
257	R:R:P283	R:R:V282	3.53	No	No	0	5	3
258	R:R:K288	R:R:W284	11.6	Yes	Yes	0	8	8
259	R:R:I308	R:R:W284	4.7	No	Yes	0	8	8
260	R:R:I309	R:R:W284	11.74	Yes	Yes	1	7	8
261	R:R:V287	R:R:Y305	6.31	No	Yes	0	4	4
262	R:R:I308	R:R:V287	4.61	No	No	0	8	4
263	R:R:E292	R:R:K288	10.8	No	Yes	0	6	8
264	R:R:K288	R:R:W297	17.4	Yes	Yes	0	8	8
265	R:R:D293	R:R:Y289	9.2	No	No	8	7	3
266	R:R:W297	R:R:Y289	3.86	Yes	No	8	8	3
267	R:R:L290	R:R:Y291	3.52	No	No	0	3	3
268	R:R:E292	R:R:N302	5.26	No	No	16	6	5
269	R:R:E292	R:R:Y305	11.22	No	Yes	16	6	4
270	R:R:D293	R:R:W297	7.82	No	Yes	8	7	8
271	R:R:E294	R:R:S301	5.75	No	No	0	4	3
272	R:R:G295	R:R:R299	4.5	No	Yes	0	4	4
273	R:R:R299	R:R:T298	5.17	Yes	Yes	5	4	5
274	L:L:S17	R:R:T298	7.99	No	Yes	5	0	5
275	L:L:S17	R:R:R299	10.54	No	Yes	5	0	4
276	L:L:S18	R:R:R299	5.27	No	Yes	0	0	4
277	L:L:E21	R:R:R299	23.26	No	Yes	0	0	4
278	R:R:N300	R:R:W306	24.86	No	Yes	0	6	6
279	L:L:S14	R:R:N300	7.45	No	No	0	0	6
280	R:R:N302	R:R:N304	6.81	No	No	0	5	3
281	R:R:N302	R:R:Y305	19.77	No	Yes	16	5	4
282	R:R:M303	R:R:W306	3.49	Yes	Yes	1	5	6
283	R:R:M303	R:R:R310	4.96	Yes	Yes	1	5	6
284	R:R:D372	R:R:M303	8.32	Yes	Yes	1	5	5
285	R:R:E373	R:R:M303	5.41	Yes	Yes	1	4	5
286	R:R:I309	R:R:W306	7.05	Yes	Yes	1	7	6
287	R:R:R310	R:R:W306	24.99	Yes	Yes	1	6	6
288	L:L:H7	R:R:W306	8.46	Yes	Yes	1	0	6
289	R:R:L307	R:R:R310	10.93	No	Yes	0	7	6
290	R:R:L307	R:R:L311	6.92	No	No	0	7	4
291	R:R:M371	R:R:R310	3.72	No	Yes	1	7	6
292	R:R:E373	R:R:R310	9.3	Yes	Yes	1	4	6
293	L:L:H7	R:R:I313	3.98	Yes	No	0	0	7
294	R:R:F315	R:R:V319	5.24	No	No	0	4	6
295	R:R:E364	R:R:I317	4.1	Yes	Yes	1	8	7
296	R:R:I323	R:R:V319	3.07	No	No	0	8	6
297	R:R:F321	R:R:V325	3.93	No	No	0	6	5
298	R:R:F321	R:R:V365	9.18	No	No	0	6	6
299	R:R:F324	R:R:I328	8.79	Yes	No	7	9	7
300	R:R:F324	R:R:T353	3.89	Yes	No	7	9	9
301	R:R:F324	R:R:L356	8.53	Yes	No	0	9	9
302	R:R:F324	R:R:I357	3.77	Yes	Yes	7	9	8
303	R:R:F324	R:R:T362	10.38	Yes	No	7	9	7
304	R:R:I328	R:R:T353	6.08	No	No	7	7	9
305	R:R:S352	R:R:V331	3.23	No	No	0	9	8
306	R:R:L349	R:R:V332	4.47	No	No	0	9	6
307	R:R:L335	R:R:R348	6.07	No	No	0	8	8
308	R:R:D344	R:R:K346	5.53	No	No	0	7	6
309	R:R:K351	R:R:R348	8.66	No	No	0	8	8
310	R:R:L401	R:R:T355	4.42	No	No	0	8	8
311	R:R:L356	R:R:L360	4.15	No	No	0	9	9
312	R:R:I357	R:R:P358	3.39	Yes	No	0	8	9
313	R:R:I357	R:R:T362	6.08	Yes	No	7	8	7
314	R:R:M397	R:R:P358	10.06	No	No	0	5	9
315	R:R:L401	R:R:P358	4.93	No	No	0	8	9
316	R:R:L359	R:R:Y402	23.45	No	No	3	9	8
317	R:R:G361	R:R:H363	3.18	No	Yes	1	9	8
318	R:R:G361	R:R:Q394	4.93	No	Yes	1	9	9
319	R:R:E364	R:R:H363	17.23	Yes	Yes	1	8	8
320	R:R:F390	R:R:H363	14.71	No	Yes	0	6	8
321	R:R:H363	R:R:Q394	13.6	Yes	Yes	1	8	9
322	R:R:E364	R:R:T391	4.23	Yes	No	0	8	6
323	R:R:F367	R:R:V370	7.87	Yes	No	0	7	5
324	R:R:F367	R:R:I382	5.02	Yes	No	0	7	4
325	R:R:F367	R:R:T386	7.78	Yes	No	0	7	4
326	R:R:E387	R:R:F367	3.5	No	Yes	0	8	7
327	R:R:L379	R:R:V370	4.47	No	No	0	3	5
328	R:R:E373	R:R:M371	5.41	Yes	No	1	4	7
329	R:R:H374	R:R:M371	7.88	No	No	1	3	7
330	R:R:D372	R:R:R376	3.57	Yes	No	1	5	5
331	R:R:D372	R:R:R380	11.91	Yes	No	1	5	5
332	L:L:T11	R:R:D372	8.67	No	Yes	0	0	5
333	R:R:E373	R:R:H374	6.15	Yes	No	1	4	3
334	R:R:R376	R:R:R380	5.33	No	No	1	5	5
335	L:L:D15	R:R:R380	8.34	No	No	0	0	5
336	R:R:E387	R:R:K383	13.5	No	No	0	8	7
337	L:L:?8	R:R:E387	8.88	Yes	No	0	0	8
338	L:L:?8	R:R:L388	3.98	Yes	Yes	1	0	7
339	L:L:E9	R:R:L388	3.98	Yes	Yes	1	0	7
340	L:L:F12	R:R:L388	3.65	Yes	Yes	1	0	7
341	L:L:E9	R:R:T391	4.23	Yes	No	0	0	6
342	R:R:F393	R:R:S392	6.61	No	No	1	7	9
343	R:R:M397	R:R:Q394	4.08	No	Yes	0	5	9
344	R:R:I400	R:R:L396	5.71	No	No	0	6	7
345	R:R:F404	R:R:I400	3.77	Yes	No	0	8	6
346	R:R:L401	R:R:Y402	3.52	No	No	0	8	8
347	R:R:C403	R:R:F404	5.59	No	Yes	0	9	8
348	R:R:E408	R:R:N406	6.57	No	No	0	9	9
349	R:R:N406	R:R:V409	7.39	No	No	0	9	9
350	R:R:Q410	R:R:R414	8.18	No	No	0	7	6
351	R:R:K415	R:R:L411	7.05	Yes	No	0	7	4
352	R:R:E412	R:R:K415	9.45	Yes	Yes	6	8	7
353	R:R:K415	R:R:R419	8.66	Yes	No	0	7	7
354	R:R:R421	R:R:W417	20.99	No	No	0	4	5
355	R:R:R421	R:R:W420	10	No	No	0	4	4
356	L:L:?8	L:L:H7	4.92	Yes	Yes	1	0	0
357	L:L:E9	L:L:H7	3.69	Yes	Yes	1	0	0
358	L:L:G10	L:L:H7	4.77	No	Yes	1	0	0
359	L:L:?8	L:L:E9	11.42	Yes	Yes	1	0	0
360	L:L:?8	L:L:G10	3.28	Yes	No	1	0	0
361	L:L:?8	L:L:T11	9.88	Yes	No	0	0	0
362	L:L:G10	L:L:T13	3.64	No	No	0	0	0
363	L:L:F12	L:L:V16	6.55	Yes	No	1	0	0
364	L:L:L20	L:L:Y19	3.52	No	No	0	0	0
365	L:L:Q23	L:L:Y19	14.65	No	No	0	0	0
366	L:L:K26	L:L:Q23	8.14	No	No	12	0	0
367	L:L:?37	L:L:Q23	13.86	Yes	No	12	0	0
368	L:L:?37	L:L:K26	26.1	Yes	No	12	0	0
369	L:L:?37	L:L:E27	18.39	Yes	No	0	0	0
370	L:L:F28	L:L:W31	4.01	Yes	Yes	2	0	0
371	L:L:F28	L:L:L32	10.96	Yes	No	2	0	0
372	L:L:R34	L:L:W31	7	No	Yes	0	0	0
373	L:L:R36	L:L:W31	15.99	Yes	Yes	0	0	0
374	R:R:K351	R:R:T355	3	No	No	0	8	8
375	R:R:L32	R:R:V36	2.98	No	No	0	4	2
376	R:R:L154	R:R:V150	2.98	No	No	0	5	5
377	R:R:L231	R:R:V281	2.98	No	No	0	5	6
378	R:R:L245	R:R:V319	2.98	No	No	0	8	6
379	R:R:L278	R:R:V282	2.98	No	No	0	3	3
380	R:R:L356	R:R:V327	2.98	No	No	0	9	9
381	R:R:L335	R:R:V331	2.98	No	No	0	8	8
382	R:R:L349	R:R:T353	2.95	No	No	0	9	9
383	R:R:D222	R:R:S219	2.94	No	No	0	6	5
384	R:R:I330	R:R:K334	2.91	No	No	0	9	9
385	R:R:P119	R:R:R102	2.88	No	Yes	0	6	8
386	R:R:I188	R:R:L159	2.85	No	Yes	0	7	9
387	R:R:I188	R:R:L192	2.85	No	No	0	7	3
388	R:R:I317	R:R:L314	2.85	Yes	No	0	7	4
389	R:R:C104	R:R:F103	2.79	No	Yes	0	9	4
390	R:R:A158	R:R:F404	2.77	No	Yes	0	7	8
391	R:R:A200	R:R:F230	2.77	No	Yes	0	4	5
392	R:R:A368	R:R:F369	2.77	No	No	0	6	4
393	R:R:E418	R:R:K415	2.7	No	Yes	0	4	7
394	R:R:F260	R:R:S258	2.64	No	No	0	7	7
395	R:R:R326	R:R:V325	2.62	No	No	0	8	5
396	R:R:F369	R:R:V365	2.62	No	No	0	4	6
397	R:R:F404	R:R:I161	2.51	Yes	No	0	8	4
398	R:R:F266	R:R:I179	2.51	No	Yes	0	6	8
399	R:R:F367	R:R:I366	2.51	Yes	No	0	7	6
400	R:R:S261	R:R:W264	2.47	No	No	0	7	5
401	R:R:L224	R:R:R227	2.43	No	No	0	3	8
402	R:R:Q45	R:R:W87	2.19	No	Yes	0	5	3
403	R:R:F195	R:R:Y152	2.06	No	Yes	0	7	7
404	R:R:G275	R:R:P277	2.03	No	No	0	6	9
405	R:R:Y291	R:R:Y305	1.99	No	Yes	0	3	4
406	R:R:C62	R:R:G108	1.96	No	No	0	9	9
407	R:R:P54	R:R:P55	1.95	No	No	0	2	1
408	R:R:P55	R:R:P56	1.95	No	Yes	0	1	1
409	R:R:A106	R:R:G78	1.95	No	No	0	1	7
410	L:L:A25	L:L:G22	1.95	No	No	0	0	0
411	R:R:C104	R:R:P77	1.88	No	No	0	9	4
412	L:L:G22	R:R:V30	1.84	No	No	0	0	2
413	R:R:G98	R:R:V95	1.84	No	No	0	4	5
414	R:R:G151	R:R:V150	1.84	No	No	0	8	5
415	R:R:P90	R:R:V30	1.77	Yes	No	0	4	2
416	R:R:P73	R:R:V81	1.77	No	No	0	5	6
417	R:R:G318	R:R:I317	1.76	No	Yes	0	4	7
418	R:R:P56	R:R:T58	1.75	Yes	No	0	1	1
419	R:R:G285	R:R:K288	1.74	No	Yes	0	5	8
420	R:R:G108	R:R:L109	1.71	No	No	0	9	5
421	R:R:G168	R:R:L167	1.71	No	No	0	1	3
422	R:R:A208	R:R:S206	1.71	No	No	0	4	4
423	R:R:C329	R:R:V325	1.71	No	No	0	7	5
424	R:R:A375	R:R:V370	1.7	No	No	0	4	5
425	R:R:E294	R:R:G295	1.64	No	No	0	4	4
426	R:R:S333	R:R:V332	1.62	No	No	0	7	6
427	R:R:A92	R:R:L89	1.58	No	Yes	0	5	5
428	R:R:E76	R:R:P77	1.57	No	No	0	1	4
429	R:R:A337	R:R:N338	1.56	No	No	0	7	6
430	R:R:I196	R:R:V229	1.54	No	No	0	5	7
431	R:R:I286	R:R:V282	1.54	No	No	0	4	3
432	R:R:I400	R:R:V405	1.54	No	No	0	6	6
433	R:R:K113	R:R:S116	1.53	No	No	0	4	5
434	R:R:A106	R:R:E107	1.51	No	No	0	1	5
435	R:R:G216	R:R:R40	1.5	No	No	0	2	2
436	R:R:L118	R:R:S117	1.5	No	No	0	4	7
437	R:R:L181	R:R:S163	1.5	No	No	0	6	6
438	R:R:L268	R:R:S271	1.5	No	No	0	2	3
439	R:R:G377	R:R:R376	1.5	No	No	0	4	5
440	L:L:G35	L:L:R36	1.5	No	Yes	0	0	0
441	R:R:I345	R:R:K346	1.45	No	No	0	5	6
442	R:R:E127	R:R:S124	1.44	No	No	0	2	5
443	R:R:E128	R:R:S129	1.44	No	No	0	3	1
444	R:R:Q263	R:R:S261	1.44	No	No	0	5	7
445	R:R:I330	R:R:L255	1.43	No	No	0	9	8
446	R:R:I345	R:R:L335	1.43	No	No	0	5	8
447	R:R:I357	R:R:L354	1.43	Yes	No	0	8	8
448	R:R:E52	R:R:T51	1.41	No	No	0	2	4
449	R:R:A153	R:R:F195	1.39	No	No	0	6	7
450	R:R:L228	R:R:L231	1.38	No	No	0	4	5
451	R:R:D215	R:R:L217	1.36	No	No	0	3	4
452	R:R:D114	R:R:N115	1.35	No	No	0	4	4
453	R:R:F381	R:R:T378	1.3	Yes	No	0	4	2
454	R:R:R102	R:R:T65	1.29	Yes	No	0	8	5
455	R:R:F66	R:R:L50	1.22	No	No	0	7	4
456	R:R:L322	R:R:R326	1.21	No	No	0	5	8
457	R:R:D215	R:R:W214	1.12	No	Yes	0	3	1
458	R:R:E41	R:R:W87	1.09	No	Yes	0	4	3
459	R:R:E418	R:R:W417	1.09	No	No	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:W39	6.802	5	2	5
2	R:R:Y42	7.752	5	2	6
3	R:R:P56	7.035	4	9	1
4	R:R:Y69	8.0275	4	2	6
5	R:R:W72	11.6933	6	10	9
6	R:R:P86	8.275	4	2	8
7	R:R:W87	5.6	4	0	3
8	R:R:Y88	7.78667	6	2	5
9	R:R:L89	5.04286	7	2	5
10	R:R:P90	6.464	5	2	4
11	R:R:W91	10.6725	4	2	4
12	R:R:Y101	9.305	4	4	5
13	R:R:R102	17.035	4	0	8
14	R:R:F103	11.038	5	11	4
15	R:R:D122	6.6325	4	4	7
16	R:R:L144	4.51	4	1	6
17	R:R:Y145	8.225	4	1	5
18	R:R:Y148	6.9025	4	1	7
19	R:R:Y152	6.46833	6	1	7
20	R:R:L159	3.8775	4	0	9
21	R:R:R176	4.486	5	3	9
22	R:R:I179	4.915	4	0	8
23	R:R:H180	7.735	4	3	9
24	R:R:F187	9.542	5	0	8
25	R:R:R190	9.92	5	1	8
26	R:R:K197	8.485	4	0	6
27	R:R:D198	6.4425	4	1	7
28	R:R:M204	7.865	4	5	3
29	R:R:Y205	7.7	5	5	3
30	R:R:W214	11.5225	4	2	1
31	R:R:F230	5.11	5	0	5
32	R:R:Q234	5.6575	4	1	7
33	R:R:Y241	8.7	4	1	8
34	R:R:Y242	5.5725	4	15	6
35	R:R:W243	12.058	5	13	9
36	R:R:V246	4.33	4	0	8
37	R:R:E247	11.34	4	3	9
38	R:R:Y250	8.116	5	0	8
39	R:R:Y269	6.68	5	0	7
40	R:R:V276	5.045	4	15	3
41	R:R:W284	8.6525	4	1	8
42	R:R:K288	10.385	4	0	8
43	R:R:W297	10.7675	4	8	8
44	R:R:T298	6.365	4	5	5
45	R:R:R299	8.81	6	5	4
46	R:R:M303	5.545	4	1	5
47	R:R:Y305	9.8225	4	16	4
48	R:R:W306	12.0233	6	1	6
49	R:R:I309	6.495	4	1	7
50	R:R:R310	10.78	5	1	6
51	R:R:I317	3.3875	4	1	7
52	R:R:F324	7.072	5	7	9
53	R:R:I357	3.6675	4	7	8
54	R:R:H363	12.18	4	1	8
55	R:R:E364	8.0725	4	1	8
56	R:R:F367	5.336	5	0	7
57	R:R:D372	8.1175	4	1	5
58	R:R:E373	6.5675	4	1	4
59	R:R:F381	4.6775	4	0	4
60	R:R:L388	3.856	5	1	7
61	R:R:Q394	7.694	5	1	9
62	R:R:F404	3.66	4	0	8
63	R:R:E412	9.35	4	6	8
64	R:R:K415	6.358	5	6	7
65	L:L:H7	7.09857	7	1	0
66	L:L:?8	7.06	6	1	0
67	L:L:E9	6.94667	6	1	0
68	L:L:F12	6.126	5	1	0
69	L:L:F28	9.362	5	2	0
70	L:L:W31	12.8425	4	2	0
71	L:L:R36	9.1125	4	0	0
72	L:L:?37	15.355	4	12	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Q213	R:R:Q221	93.9045	6.4	No	No	0	4	4
2	R:R:L32	R:R:Q213	93.6838	6.65	No	No	0	4	4
3	R:R:L32	R:R:V36	93.6254	2.98	No	No	0	4	2
4	L:L:F28	R:R:V36	93.5657	11.8	Yes	No	0	0	2
5	L:L:F28	R:R:W39	47.0389	6.01	Yes	Yes	2	0	5
6	R:R:W39	R:R:Y88	41.8438	6.75	Yes	Yes	2	5	5
7	L:L:F28	L:L:L32	41.1577	10.96	Yes	No	2	0	0
8	L:L:L32	R:R:Y88	40.9642	3.52	No	Yes	2	0	5
9	R:R:Y42	R:R:Y88	14.3104	14.89	Yes	Yes	2	6	5
10	R:R:L50	R:R:R64	13.4022	4.86	No	No	0	4	4
11	R:R:F66	R:R:L50	14.6129	1.22	No	No	0	7	4
12	R:R:Y69	R:R:Y88	32.5442	5.96	Yes	Yes	2	6	5
13	R:R:L123	R:R:Y69	32.3787	9.38	No	Yes	2	5	6
14	R:R:L123	R:R:R121	31.218	10.93	No	No	2	5	6
15	R:R:D67	R:R:R121	30.6831	3.57	No	No	0	9	6
16	R:R:D67	R:R:W72	30.1203	7.82	No	Yes	0	9	9
17	R:R:R102	R:R:W72	55.5375	39.98	Yes	Yes	0	8	9
18	R:R:R102	R:R:W110	48.4515	23.99	Yes	No	0	8	9
19	R:R:C62	R:R:W110	47.2655	11.75	No	No	0	9	9
20	R:R:C104	R:R:C62	43.6997	7.28	No	No	0	9	9
21	R:R:P86	R:R:Y88	32.5572	9.74	Yes	Yes	2	8	5
22	R:R:C85	R:R:P86	32.3916	3.77	No	Yes	0	9	8
23	R:R:C126	R:R:C85	31.8243	7.28	No	No	0	9	9
24	R:R:C126	R:R:V100	31.2576	3.42	No	No	0	9	7
25	R:R:V100	R:R:W72	30.0872	6.13	No	Yes	10	7	9
26	R:R:C104	R:R:F103	37.7309	2.79	No	Yes	0	9	4
27	R:R:F103	R:R:F80	15.8573	24.65	Yes	No	0	4	4
28	R:R:F80	R:R:W120	14.6447	5.01	No	No	0	4	5
29	R:R:F103	R:R:L111	15.8566	4.87	Yes	No	11	4	4
30	R:R:L111	R:R:W120	14.6525	7.97	No	No	0	4	5
31	R:R:D122	R:R:W120	26.8622	3.35	Yes	No	0	7	5
32	R:R:D122	R:R:Y101	17.1075	6.9	Yes	Yes	4	7	5
33	R:R:H99	R:R:Y101	12.2325	9.8	No	Yes	4	4	5
34	R:R:F230	R:R:T298	100	7.78	Yes	Yes	0	5	5
35	R:R:F230	R:R:K197	78.4153	6.2	Yes	Yes	0	5	6
36	R:R:D198	R:R:K197	56.4314	4.15	Yes	Yes	0	7	6
37	R:R:D198	R:R:V194	47.5985	4.38	Yes	No	0	7	7
38	R:R:V194	R:R:Y152	47.481	10.09	No	Yes	0	7	7
39	R:R:R190	R:R:Y152	44.4002	8.23	Yes	Yes	1	8	7
40	L:L:G10	L:L:H7	31.4445	4.77	No	Yes	1	0	0
41	L:L:G10	L:L:T13	43.3778	3.64	No	No	0	0	0
42	L:L:T13	R:R:K197	21.7197	13.51	No	Yes	0	0	6
43	L:L:?8	L:L:G10	11.8475	3.28	Yes	No	1	0	0
44	L:L:T13	R:R:L201	21.7866	4.42	No	No	0	0	7
45	R:R:F230	R:R:L201	21.6087	4.87	Yes	No	0	5	7
46	R:R:N240	R:R:R190	55.6349	10.85	No	Yes	0	9	8
47	R:R:F187	R:R:N240	33.6088	18.12	Yes	No	0	8	9
48	R:R:E408	R:R:R176	11.2945	3.49	No	Yes	0	9	9
49	R:R:H180	R:R:R176	10.731	5.64	Yes	Yes	3	9	9
50	R:R:E247	R:R:H180	11.2659	16	Yes	Yes	3	9	9
51	R:R:E247	R:R:L183	16.0923	11.93	Yes	No	0	9	9
52	R:R:F187	R:R:L183	16.3331	6.09	Yes	No	0	8	9
53	R:R:N240	R:R:S186	23.0498	5.96	No	No	0	9	9
54	R:R:S186	R:R:W243	22.7291	7.41	No	Yes	0	9	9
55	R:R:V246	R:R:W243	19.7625	6.13	Yes	Yes	0	8	9
56	R:R:F187	R:R:Q394	12.0325	10.54	Yes	Yes	0	8	9
57	R:R:M204	R:R:T298	92.6342	4.52	Yes	Yes	5	3	5
58	R:R:K288	R:R:W284	10.929	11.6	Yes	Yes	0	8	8
59	R:R:Q234	R:R:W284	15.6755	6.57	Yes	Yes	1	7	8
60	L:L:H7	R:R:Q234	19.5048	8.65	Yes	Yes	1	0	7
61	L:L:H7	R:R:W306	13.8352	8.46	Yes	Yes	1	0	6
62	R:R:I272	R:R:V246	12.7758	3.07	No	Yes	0	6	8
63	R:R:I272	R:R:V276	11.3464	4.61	No	Yes	0	6	3
64	R:R:M397	R:R:Q394	13.0835	4.08	No	Yes	0	5	9
65	R:R:M397	R:R:P358	12.5622	10.06	No	No	0	5	9
66	R:R:E364	R:R:H363	10.3168	17.23	Yes	Yes	1	8	8
67	R:R:M204	R:R:Q221	89.726	10.88	Yes	No	5	3	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E34	R:R:S31	8.62	0	No	No	4	4	2	1
L:L:E21	R:R:S31	7.19	0	No	No	0	4	0	1
R:R:P90	R:R:T35	6.99	2	Yes	No	4	5	1	2
L:L:F28	R:R:V36	11.8	2	Yes	No	0	2	0	1
R:R:R43	R:R:W39	6	0	No	Yes	4	5	2	1
R:R:W39	R:R:Y88	6.75	2	Yes	Yes	5	5	1	1
L:L:F28	R:R:W39	6.01	2	Yes	Yes	0	5	0	1
L:L:L32	R:R:W39	10.25	2	No	Yes	0	5	0	1
L:L:R36	R:R:W39	5	0	Yes	Yes	0	5	0	1
R:R:F66	R:R:Y42	3.09	0	No	Yes	7	6	2	2
R:R:Y42	R:R:Y88	14.89	2	Yes	Yes	6	5	2	1
R:R:E68	R:R:F66	5.83	0	No	No	4	7	1	2
R:R:D67	R:R:R121	3.57	0	No	No	9	6	2	1
L:L:R36	R:R:E68	13.96	0	Yes	No	0	4	0	1
R:R:P86	R:R:Y69	9.74	2	Yes	Yes	8	6	2	2
R:R:Y69	R:R:Y88	5.96	2	Yes	Yes	6	5	2	1
R:R:L89	R:R:Y69	7.03	2	Yes	Yes	5	6	1	2
R:R:L123	R:R:Y69	9.38	2	No	Yes	5	6	1	2
R:R:P86	R:R:Y88	9.74	2	Yes	Yes	8	5	2	1
R:R:L89	R:R:P86	9.85	2	Yes	Yes	5	8	1	2
R:R:L89	R:R:Y88	5.86	2	Yes	Yes	5	5	1	1
L:L:L32	R:R:Y88	3.52	2	No	Yes	0	5	0	1
R:R:L89	R:R:P90	3.28	2	Yes	Yes	5	4	1	1
R:R:L89	R:R:W91	3.42	2	Yes	Yes	5	4	1	1
L:L:I29	R:R:L89	4.28	2	No	Yes	0	5	0	1
R:R:P90	R:R:W91	13.51	2	Yes	Yes	4	4	1	1
L:L:I29	R:R:P90	6.77	2	No	Yes	0	4	0	1
R:R:E128	R:R:W91	16.36	0	No	Yes	3	4	2	1
L:L:I29	R:R:W91	9.4	2	No	Yes	0	4	0	1
R:R:L123	R:R:R121	10.93	2	No	No	5	6	1	1
L:L:V33	R:R:R121	5.23	2	No	No	0	6	0	1
L:L:V33	R:R:L123	4.47	2	No	No	0	5	0	1
L:L:Y19	R:R:E138	13.47	0	No	No	0	2	0	1
L:L:?37	R:R:E138	3.07	12	Yes	No	0	2	0	1
L:L:F12	R:R:L141	6.09	1	Yes	No	0	5	0	1
L:L:V16	R:R:L141	5.96	1	No	No	0	5	0	1
R:R:F381	R:R:L144	3.65	0	Yes	Yes	4	6	2	1
R:R:L144	R:R:L384	4.15	1	Yes	No	6	5	1	2
R:R:L144	R:R:L388	4.15	1	Yes	Yes	6	7	1	1
L:L:F12	R:R:L144	6.09	1	Yes	Yes	0	6	0	1
R:R:Y145	R:R:Y148	8.94	1	Yes	Yes	5	7	2	1
R:R:D198	R:R:Y145	10.34	1	Yes	Yes	7	5	2	2
R:R:D198	R:R:Y148	6.9	1	Yes	Yes	7	7	2	1
R:R:L388	R:R:Y148	3.52	1	Yes	Yes	7	7	1	1
L:L:F12	R:R:Y148	8.25	1	Yes	Yes	0	7	0	1
R:R:R190	R:R:Y152	8.23	1	Yes	Yes	8	7	1	1
R:R:A191	R:R:Y152	5.34	0	No	Yes	7	7	2	1
R:R:V194	R:R:Y152	10.09	0	No	Yes	7	7	2	1
R:R:S392	R:R:Y152	6.36	1	No	Yes	9	7	2	1
L:L:E9	R:R:Y152	6.73	1	Yes	Yes	0	7	0	1
R:R:R190	R:R:V237	6.54	1	Yes	No	8	6	1	1
R:R:N240	R:R:R190	10.85	0	No	Yes	9	8	2	1
R:R:R190	R:R:Y241	12.35	1	Yes	Yes	8	8	1	2
L:L:E9	R:R:R190	11.63	1	Yes	Yes	0	8	0	1
R:R:D198	R:R:V194	4.38	1	Yes	No	7	7	2	2
R:R:D198	R:R:K197	4.15	1	Yes	Yes	7	6	2	1
R:R:F230	R:R:K197	6.2	0	Yes	Yes	5	6	2	1
R:R:K197	R:R:M233	10.08	0	Yes	No	6	6	1	2
L:L:T13	R:R:K197	13.51	0	No	Yes	0	6	0	1
R:R:F230	R:R:L201	4.87	0	Yes	No	5	7	2	1
L:L:T13	R:R:L201	4.42	0	No	No	0	7	0	1
R:R:M204	R:R:Y205	9.58	5	Yes	Yes	3	3	2	1
R:R:M204	R:R:Q221	10.88	5	Yes	No	3	4	2	2
R:R:M204	R:R:T298	4.52	5	Yes	Yes	3	5	2	1
R:R:Q221	R:R:Y205	5.64	5	No	Yes	4	3	2	1
R:R:R299	R:R:Y205	4.12	5	Yes	Yes	4	3	1	1
L:L:S17	R:R:Y205	5.09	5	No	Yes	0	3	0	1
L:L:L20	R:R:Y205	14.07	0	No	Yes	0	3	0	1
R:R:Q210	R:R:W214	6.57	0	No	Yes	4	1	1	1
L:L:A24	R:R:Q210	4.55	0	No	No	0	4	0	1
L:L:F28	R:R:W214	14.03	2	Yes	Yes	0	1	0	1
L:L:W31	R:R:W214	24.37	2	Yes	Yes	0	1	0	1
R:R:F230	R:R:T298	7.78	0	Yes	Yes	5	5	2	1
R:R:Q234	R:R:W284	6.57	1	Yes	Yes	7	8	1	2
R:R:Q234	R:R:W306	3.29	1	Yes	Yes	7	6	1	1
R:R:I309	R:R:Q234	4.12	1	Yes	Yes	7	7	2	1
L:L:H7	R:R:Q234	8.65	1	Yes	Yes	0	7	0	1
L:L:H7	R:R:V237	15.22	1	Yes	No	0	6	0	1
R:R:A238	R:R:I313	3.25	0	No	No	6	7	2	1
R:R:I313	R:R:Y241	10.88	0	No	Yes	7	8	1	2
R:R:E364	R:R:Y241	6.73	1	Yes	Yes	8	8	2	2
R:R:I309	R:R:W284	11.74	1	Yes	Yes	7	8	2	2
R:R:G295	R:R:R299	4.5	0	No	Yes	4	4	2	1
R:R:R299	R:R:T298	5.17	5	Yes	Yes	4	5	1	1
L:L:S17	R:R:T298	7.99	5	No	Yes	0	5	0	1
L:L:S17	R:R:R299	10.54	5	No	Yes	0	4	0	1
L:L:S18	R:R:R299	5.27	0	No	Yes	0	4	0	1
L:L:E21	R:R:R299	23.26	0	No	Yes	0	4	0	1
R:R:N300	R:R:W306	24.86	0	No	Yes	6	6	1	1
L:L:S14	R:R:N300	7.45	0	No	No	0	6	0	1
R:R:M303	R:R:W306	3.49	1	Yes	Yes	5	6	2	1
R:R:M303	R:R:R310	4.96	1	Yes	Yes	5	6	2	2
R:R:D372	R:R:M303	8.32	1	Yes	Yes	5	5	1	2
R:R:I309	R:R:W306	7.05	1	Yes	Yes	7	6	2	1
R:R:R310	R:R:W306	24.99	1	Yes	Yes	6	6	2	1
L:L:H7	R:R:W306	8.46	1	Yes	Yes	0	6	0	1
L:L:H7	R:R:I313	3.98	1	Yes	No	0	7	0	1
R:R:E364	R:R:T391	4.23	1	Yes	No	8	6	2	1
R:R:E387	R:R:F367	3.5	0	No	Yes	8	7	1	2
R:R:D372	R:R:R376	3.57	1	Yes	No	5	5	1	2
R:R:D372	R:R:R380	11.91	1	Yes	No	5	5	1	1
L:L:T11	R:R:D372	8.67	0	No	Yes	0	5	0	1
R:R:R376	R:R:R380	5.33	1	No	No	5	5	2	1
L:L:D15	R:R:R380	8.34	0	No	No	0	5	0	1
R:R:E387	R:R:K383	13.5	0	No	No	8	7	1	2
L:L:?8	R:R:E387	8.88	1	Yes	No	0	8	0	1
L:L:?8	R:R:L388	3.98	1	Yes	Yes	0	7	0	1
L:L:E9	R:R:L388	3.98	1	Yes	Yes	0	7	0	1
L:L:F12	R:R:L388	3.65	1	Yes	Yes	0	7	0	1
L:L:E9	R:R:T391	4.23	1	Yes	No	0	6	0	1
R:R:L32	R:R:V36	2.98	0	No	No	4	2	2	1
R:R:F195	R:R:Y152	2.06	0	No	Yes	7	7	2	1
L:L:G22	R:R:V30	1.84	0	No	No	0	2	0	1
R:R:P90	R:R:V30	1.77	2	Yes	No	4	2	1	1
R:R:A92	R:R:L89	1.58	0	No	Yes	5	5	2	1
R:R:D215	R:R:W214	1.12	0	No	Yes	3	1	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7KI0_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.07
Number of Linked Nodes	390
Number of Links	459
Number of Hubs	72
Number of Links mediated by Hubs	250
Number of Communities	16
Number of Nodes involved in Communities	110
Number of Links involved in Communities	148

Path Summary
Number Of Nodes in MetaPath	68
Number Of Links MetaPath	67
Number of Shortest Paths	229302
Length Of Smallest Path	3
Average Path Length	21.9022
Length of Longest Path	51
Minimum Path Strength	1.24
Average Path Strength	7.85312
Maximum Path Strength	31.985
Minimum Path Correlation	0.7
Average Path Correlation	0.965368
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	59.5204
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	49.1002
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • signaling receptor binding • molecular transducer activity • molecular function activator activity • signaling receptor activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • G protein-coupled receptor binding • glucagon receptor binding • hormone activity • identical protein binding • monosaccharide metabolic process • positive regulation of biological process • gluconeogenesis • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • small molecule metabolic process • regulation of carbohydrate metabolic process • regulation of glucose metabolic process • positive regulation of cellular process • positive regulation of gluconeogenesis • regulation of biosynthetic process • carbohydrate metabolic process • small molecule biosynthetic process • carbohydrate biosynthetic process • hexose metabolic process • primary metabolic process • monosaccharide biosynthetic process • hexose biosynthetic process • positive regulation of glucose metabolic process • biosynthetic process • regulation of gluconeogenesis • metabolic process • positive regulation of carbohydrate metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • glucose metabolic process • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • negative regulation of programmed cell death • regulation of apoptotic process • negative regulation of biological process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • negative regulation of cellular process • apoptotic process • programmed cell death • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • response to activity • protein kinase A signaling • negative regulation of execution phase of apoptosis • regulation of execution phase of apoptosis • execution phase of apoptosis • behavior • feeding behavior • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of biological quality • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • positive regulation of establishment of protein localization • carbohydrate homeostasis • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • positive regulation of peptide hormone secretion • intracellular glucose homeostasis • cellular response to carbohydrate stimulus • chemical homeostasis • response to glucose • glucose homeostasis • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • homeostatic process • positive regulation of secretion by cell • positive regulation of protein transport • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • cellular response to hexose stimulus • intracellular chemical homeostasis • cellular response to monosaccharide stimulus • positive regulation of peptide secretion • cellular response to glucose stimulus • positive regulation of protein secretion • response to hexose • cellular homeostasis • positive regulation of transport • regulation of insulin secretion involved in cellular response to glucose stimulus • regulation of calcium ion import • regulation of calcium ion transport • positive regulation of calcium ion transport • positive regulation of calcium ion import • regulation of monoatomic ion transport • calcium ion transport • metal ion transport • positive regulation of monoatomic ion transport • monoatomic ion transport • calcium ion import • monoatomic cation transport • regulation of metal ion transport • membrane-enclosed lumen • intracellular organelle lumen • endoplasmic reticulum lumen • organelle lumen • endoplasmic reticulum • vesicle lumen • intracellular vesicle • cytoplasmic vesicle lumen • secretory granule lumen • cytoplasmic vesicle • secretory granule • secretory vesicle • glucagon receptor activity • peptide receptor activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • transmembrane signaling receptor activity • amide binding • peptide hormone binding • hormone binding • glucagon-like peptide 1 receptor activity • positive regulation of cytosolic calcium ion concentration • heart process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • regulation of blood pressure • positive regulation of blood pressure • response to stress • response to psychosocial stress • cell surface receptor signaling pathway • learning or memory • cognition • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • protein targeting • protein transmembrane transport • post-translational protein targeting to membrane, translocation • establishment of protein localization to endoplasmic reticulum • protein localization to endoplasmic reticulum • establishment of protein localization to membrane • intracellular protein transmembrane transport • intracellular transport • post-translational protein targeting to endoplasmic reticulum membrane • localization within membrane • protein localization to membrane • protein targeting to membrane • transmembrane transport • establishment of protein localization to organelle • protein localization to organelle • intracellular protein transport • protein targeting to ER • negative regulation of blood pressure
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • FnI-like domain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • FnI-like domain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	AIB
PDB Residues	L:L:?8
Environment Details	Open EMBL-EBI Page
Code	AIB
Name	2-aminoisobutyric acid
Synonyms	α,α-dimethylglycine
Identifier
Formula	C4 H9 N O2
Molecular Weight	103.12
SMILES
PubChem	5245672
Formal Charge	0
Total Atoms	16
Total Chiral Atoms	0
Total Bonds	15
Total Aromatic Bonds	0


Code	WF1
PDB Residues	L:L:?37
Environment Details	Open EMBL-EBI Page
Code	WF1
Name	17-amino-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecan-1-oic acid
Synonyms
Identifier
Formula	C12 H24 N2 O7
Molecular Weight	308.328
SMILES
PubChem	51340918
Formal Charge	0
Total Atoms	45
Total Chiral Atoms	0
Total Bonds	44
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P43220
Sequence	>7KI0_nogp_Chain_R T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S P E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F R H L H C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S T A A Q Q H Q W D G L L S Y Q D S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S V F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E D E G C W T R N S N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L D I K C R L A K S T L T L I P L L G T H E V I F A F V M D E H A R G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E V Q L E F R K S W E R W R L E Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9IVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839	chim(NtGi1-Gs)/β2/γ2	3.22	2024-11-13	10.1016/j.apsb.2024.09.002
	9IVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839		3.22	2024-11-13	10.1016/j.apsb.2024.09.002
	8YW3	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-	Gs/β1/γ2	2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW3 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-		2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8WG7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.54	2024-03-06	10.1038/s41421-024-00649-0
	8WG7 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.54	2024-03-06	10.1038/s41421-024-00649-0
	8JIS	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-	chim(NtGi1-Gs)/β1/γ2	2.46	2023-11-08	10.1073/pnas.2303696120
	8JIS (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-		2.46	2023-11-08	10.1073/pnas.2303696120
	8JIR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-	chim(NtGi1-Gs)/β1/γ2	2.57	2023-09-06	10.1073/pnas.2303696120
	8JIR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-		2.57	2023-09-06	10.1073/pnas.2303696120
	8JIP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-	chim(NtGi1-Gs)/β1/γ2	2.85	2023-09-06	10.1073/pnas.2303696120
	8JIP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-		2.85	2023-09-06	10.1073/pnas.2303696120
	9IVG	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	chim(NtGi1-Gs)/β1/γ2	3	2024-11-27	10.1016/j.apsb.2024.09.002
	9IVG (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-		3	2024-11-27	10.1016/j.apsb.2024.09.002
	9J1P	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-	chim(NtGi1-Gs)/β1/γ2	2.99	2025-02-26	10.1021/jacs.4c12808
	9J1P (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-		2.99	2025-02-26	10.1021/jacs.4c12808
	7X8S	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-	Gs/β1/γ2	3.09	2022-06-29	10.1073/pnas.2200155119
	7X8S (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-		3.09	2022-06-29	10.1073/pnas.2200155119
	7X8R	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-	Gs/β1/γ2	2.61	2022-06-29	10.1073/pnas.2200155119
	7X8R (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-		2.61	2022-06-29	10.1073/pnas.2200155119
	7S15	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 134611223	-	-	3.8	2022-06-08	10.1021/acs.jmedchem.1c01856
	7RGP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	chim(NtGi1-Gs)/β1/γ2	2.9	2022-04-13	10.1073/pnas.2116506119
	7RGP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		2.9	2022-04-13	10.1073/pnas.2116506119
	7RG9	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-04-13	10.1073/pnas.2116506119
	7RG9 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.2	2022-04-13	10.1073/pnas.2116506119
	7VBH	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-	Gs/β1/γ2	3	2022-04-06	10.1038/s41467-022-28683-0
	7VBH (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-		3	2022-04-06	10.1038/s41467-022-28683-0
	7VBI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-	Gs/β1/γ2	3	2022-03-02	10.1038/s41467-022-28683-0
	7VBI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-		3	2022-03-02	10.1038/s41467-022-28683-0
	7FIM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	10.1038/s41467-022-28683-0
	7FIM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	10.1038/s41467-022-28683-0
	7LLY	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-	Gs/β1/γ2	3.3	2022-01-12	10.1038/s41467-021-27760-0
	7LLY (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-		3.3	2022-01-12	10.1038/s41467-021-27760-0
	7LLL	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/β1/γ2	3.7	2022-01-12	10.1038/s41467-021-27760-0
	7LLL (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-		3.7	2022-01-12	10.1038/s41467-021-27760-0
	7S3I	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.51	2022-01-05	10.1038/s41589-021-00945-w
	7S3I (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.51	2022-01-05	10.1038/s41589-021-00945-w
	7S1M	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-	Gs/β1/γ2	2.41	2022-01-05	10.1038/s41589-021-00945-w
	7S1M (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-		2.41	2022-01-05	10.1038/s41589-021-00945-w
	7RTB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-	Gs/β1/γ2	2.14	2021-10-06	10.1016/j.bbrc.2021.09.016
	7RTB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-		2.14	2021-10-06	10.1016/j.bbrc.2021.09.016
	7EVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	2.5	2021-08-11	10.1038/s41467-021-24058-z
	7EVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		2.5	2021-08-11	10.1038/s41467-021-24058-z
	7DUR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	3.3	2021-08-11	10.1038/s41467-021-24058-z
	7DUR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		3.3	2021-08-11	10.1038/s41467-021-24058-z
	7KI1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-	Gs/β1/γ2	2.5	2021-08-04	10.1016/j.celrep.2021.109374
	7KI1 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-		2.5	2021-08-04	10.1016/j.celrep.2021.109374
	7KI0	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-	Gs/β1/γ2	2.5	2021-08-04	10.1016/j.celrep.2021.109374
	7KI0 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-		2.5	2021-08-04	10.1016/j.celrep.2021.109374
	7DUQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738	Gs/β1/γ2	2.5	2021-07-14	10.1038/s41467-021-24058-z
	7DUQ (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738		2.5	2021-07-14	10.1038/s41467-021-24058-z
	7E14	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738	Gs/β1/γ2	2.9	2021-07-07	10.1038/s41467-021-24058-z
	7E14 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738		2.9	2021-07-07	10.1038/s41467-021-24058-z
	7LCK	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	3.24	2021-01-20	10.1016/j.str.2021.04.008
	7LCJ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	2.82	2021-01-20	10.1016/j.str.2021.04.008
	7LCI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.9	2021-01-20	10.1016/j.str.2021.04.008
	7LCI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.9	2021-01-20	10.1016/j.str.2021.04.008
	6XOX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-	chim(NtGi1-Gs)/β1/γ2	3.1	2020-11-18	10.1073/pnas.2014879117
	6XOX (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-		3.1	2020-11-18	10.1073/pnas.2014879117
	6X1A	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.5	2020-09-09	10.1016/j.molcel.2020.09.020
	6X1A (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.5	2020-09-09	10.1016/j.molcel.2020.09.020
	6X19	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-	Gs/β1/γ2	2.1	2020-09-09	10.1016/j.molcel.2020.09.020
	6X19 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-		2.1	2020-09-09	10.1016/j.molcel.2020.09.020
	6X18	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-	Gs/β1/γ2	2.1	2020-09-09	10.1016/j.molcel.2020.09.020
	6X18 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-		2.1	2020-09-09	10.1016/j.molcel.2020.09.020
	7C2E	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-	Gs/β1/γ2	4.2	2020-08-26	10.1038/s41422-020-0384-8
	7C2E (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-		4.2	2020-08-26	10.1038/s41422-020-0384-8
	6VCB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440	Gs/β1/γ2	3.3	2020-07-22	10.1038/s41589-020-0589-7
	6VCB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440		3.3	2020-07-22	10.1038/s41589-020-0589-7
	6LN2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	3.2	2020-03-18	10.1038/s41467-020-14934-5
	6ORV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2	Gs/β1/γ2	3	2020-01-08	10.1038/s41586-019-1902-z
	6ORV (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2		3	2020-01-08	10.1038/s41586-019-1902-z
	6KK7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	3.1	2019-11-13	10.1107/S2052252519013496
	6KK1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	2.8	2019-11-13	10.1107/S2052252519013496
	6KJV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	2.8	2019-11-13	10.1107/S2052252519013496
	6B3J	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-	Gs/β1/γ2	3.3	2018-02-21	10.1038/nature25773
	6B3J (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-		3.3	2018-02-21	10.1038/nature25773
	5NX2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	-	3.7	2017-06-14	10.1038/nature22800
	5VEW	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.7	2017-05-24	10.1038/nature22378
	5VAI	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-	Gs/β1/γ2	4.1	2017-05-24	10.1038/nature22394
	5VAI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-		4.1	2017-05-24	10.1038/nature22394
	5VEX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	NNC0640	-	3	2017-05-17	10.1038/nature22378

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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