Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:D16 5.8775404
2A:A:Y37 7.47754154
3A:A:F219 5.6456178
4A:A:H220 5.3854187
5A:A:F222 7.186517
6A:A:Q227 8.3975419
7A:A:K233 6.15833619
8A:A:W234 10.4975419
9A:A:F238 11.3825419
10A:A:F246 5.455639
11A:A:Q267 6.505404
12A:A:L272 4.8625438
13A:A:F273 6.83571739
14A:A:W277 10.194536
15A:A:W281 8.07667615
16A:A:L289 4.774539
17A:A:F290 6.3045199
18A:A:F315 11.002506
19A:A:E330 4.86403
20A:A:R333 4.9025405
21A:A:V334 4.34404
22A:A:R336 7.404505
23A:A:F340 8.464507
24A:A:R342 7.588534
25A:A:L346 5.0775434
26A:A:S349 4.01537
27A:A:C359 4.618535
28A:A:Y360 7.8385118
29A:A:P361 5.785435
30A:A:F363 6.724535
31A:A:T364 7.17754199
32A:A:F376 6.9325178
33A:A:R385 5.9354115
34A:A:H387 6.72408
35A:A:L388 6.655408
36A:A:Q390 6.575424
37A:A:Y391 5.40167624
38B:B:L14 5.095408
39B:B:M45 5.6975404
40B:B:H54 6.863336129
41B:B:L55 6.564156
42B:B:K57 13.0425419
43B:B:Y59 7.6975418
44B:B:W63 7.0175407
45B:B:Q75 9.14409
46B:B:D76 5.8856159
47B:B:I80 8.44754128
48B:B:W82 8.278129
49B:B:K89 7.1675409
50B:B:H91 6.2825405
51B:B:I93 4.335407
52B:B:L95 4.81588
53B:B:W99 8.4975419
54B:B:M101 5.984519
55B:B:Y105 4.71786
56B:B:Y111 9.8404
57B:B:V112 4.5875488
58B:B:L117 4.795619
59B:B:C121 3.34418
60B:B:I123 4.6925406
61B:B:Y124 6.06333686
62B:B:E138 5.5825486
63B:B:H142 8.2375419
64B:B:Y145 6.35429718
65B:B:L146 3.545417
66B:B:C149 3.69618
67B:B:F151 5.596519
68B:B:I157 5.3675417
69B:B:T159 5.516519
70B:B:S160 6.355446
71B:B:D163 8.58519
72B:B:C166 4.3975448
73B:B:W169 7.52286718
74B:B:T173 4.74254165
75B:B:T178 5.27444
76B:B:F180 10.745447
77B:B:H183 9.4649
78B:B:D186 5.836519
79B:B:V187 4.794549
80B:B:M188 5.2525418
81B:B:F199 8.195449
82B:B:V200 9.9375476
83B:B:S201 4.6075449
84B:B:C204 5.9275417
85B:B:D205 7.485449
86B:B:K209 13.3375446
87B:B:W211 9.812548
88B:B:F222 9.6925478
89B:B:H225 10.23836139
90B:B:D228 7.08519
91B:B:I232 5.8625478
92B:B:F234 7.16475
93B:B:F235 7.96833606
94B:B:F241 8.92676
95B:B:D246 6.062519
96B:B:D247 9.2154139
97B:B:R251 8.256676138
98B:B:F253 7.70333676
99B:B:D258 9.192577
100B:B:Q259 5.46406
101B:B:M262 6.195494
102B:B:Y264 6.82333695
103B:B:L285 4.6125496
104B:B:Y289 11.184597
105B:B:N295 11.4475496
106B:B:H311 9.1765109
107B:B:R314 14.798518
108B:B:L318 5.554246
109B:B:T321 8.2325457
110B:B:M325 4.48667655
111B:B:V327 4.94246
112B:B:W332 11.1343719
113B:B:K337 8.54754106
114B:B:W339 8.7565109
115B:B:N340 8.84559
116G:G:L19 4.5525409
117G:G:R27 7.64478
118G:G:D48 6.83254259
119G:G:F61 6.895858
120R:R:Y152 5.6025277
121R:R:L166 6.5175428
122R:R:L172 6.3675429
123R:R:R176 6.868529
124R:R:I179 5.03428
125R:R:H180 7.222529
126R:R:F184 4.63571728
127R:R:F187 7.646508
128R:R:R190 8.8675408
129R:R:R227 12.6825468
130R:R:Q234 7.4425467
131R:R:N240 9.73409
132R:R:Y241 5.835408
133R:R:W243 9.538577289
134R:R:E247 8.785429
135R:R:Y250 8.85428
136R:R:F266 5.4425426
137R:R:Y269 6.37627
138R:R:W274 7.73754289
139R:R:W284 6.754568
140R:R:E292 7.9565146
141R:R:E294 4.265404
142R:R:W297 12.4067668
143R:R:F324 5.9865299
144R:R:K334 6.1154119
145R:R:R348 4.95408
146R:R:H363 10.0925408
147R:R:F367 4.9075407
148R:R:Q394 6.225409
149R:R:E412 13.3075428
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:W63 G:G:F61 11.58414.01YesYes078
2B:B:L70 B:B:W63 23.04716.83NoYes057
3B:B:L70 B:B:W82 22.90684.56NoYes059
4B:B:H54 B:B:W82 10.30693.17YesYes1299
5B:B:D76 B:B:G77 17.04383.35YesNo098
6B:B:G77 B:B:L95 14.92773.42NoYes088
7B:B:I80 B:B:W82 10.609112.92YesYes1289
8B:B:I80 B:B:K78 10.31984.36YesNo088
9B:B:L95 B:B:Y124 10.97145.86YesYes886
10B:B:A328 B:B:W63 34.76413.89NoYes057
11B:B:A328 B:B:M61 34.89584.83NoNo056
12B:B:C317 B:B:M61 67.15193.24NoNo076
13B:B:C317 B:B:S316 67.26573.44NoNo079
14B:B:S316 B:B:W332 62.00286.18NoYes199
15A:A:W281 B:B:W332 38.48133.75YesYes159
16A:A:W281 B:B:D290 55.068711.17YesNo156
17B:B:C271 B:B:D290 1003.11NoNo056
18B:B:C271 B:B:D291 99.98517.78NoNo058
19B:B:D291 B:B:N293 99.97018.08NoNo085
20B:B:A309 B:B:N293 99.9553.13NoNo035
21B:B:A309 R:R:R419 99.93984.15NoNo037
22B:B:D312 R:R:R419 99.92464.76NoNo057
23B:B:D312 R:R:H171 49.954212.61NoNo257
24R:R:E412 R:R:H171 49.910819.69YesNo287
25R:R:E412 R:R:L172 99.266414.58YesYes289
26R:R:L166 R:R:L172 97.8962.77YesYes289
27R:R:F184 R:R:L166 97.21993.65YesYes288
28R:R:F184 R:R:H180 59.9695.66YesYes289
29B:B:R314 B:B:W332 34.914723.99YesYes189
30B:B:D290 B:B:R314 44.945916.68NoYes168
31B:B:D312 R:R:K415 49.95511.06NoNo257
32R:R:E412 R:R:K415 49.910810.8YesNo287
33R:R:F184 R:R:L183 20.69373.65YesNo089
34A:A:Y391 R:R:H180 36.89663.27YesYes249
35A:A:Q390 A:A:Y391 17.5533.38YesYes244
36A:A:H387 A:A:Q390 33.18196.18YesYes084
37A:A:H387 A:A:I383 15.51613.98YesNo088
38A:A:H41 A:A:I383 15.04717.95NoNo068
39A:A:F219 A:A:H41 14.10999.05YesNo086
40R:R:H180 R:R:R176 18.40374.51YesYes299
41A:A:Q390 R:R:R176 17.476714.02YesYes249
42A:A:Y391 R:R:L254 17.09474.69YesNo048
43A:A:H387 R:R:L254 17.067612.86YesNo088
44A:A:H387 R:R:L255 34.29573.86YesNo088
45A:A:L388 R:R:L255 33.82836.92YesNo088
46A:A:L388 A:A:L394 28.6879.69YesNo088
47A:A:L394 R:R:K334 28.21954.23NoYes089
48A:A:D381 R:R:K334 13.173513.83NoYes1189
49A:A:D381 A:A:Y360 12.70469.2NoYes1188
50A:A:D378 A:A:Y360 22.59312.64NoYes078
51A:A:D378 A:A:I288 18.82629.8NoNo079
52A:A:F290 A:A:I288 16.94686.28YesNo099
53A:A:R385 R:R:K334 13.64424.95YesYes1159
54A:A:R385 A:A:Y360 12.70465.14YesYes1158
55B:B:M101 B:B:Y59 13.12579.58YesYes198
56B:B:M101 B:B:Y145 11.51884.79YesYes198
57A:A:N279 A:A:W281 13.66626.78NoYes085
58A:A:L282 A:A:N279 13.58425.49NoNo098
59A:A:I235 A:A:L282 13.50811.43NoNo099
60A:A:I235 A:A:L46 13.2281.43NoNo098
61A:A:F246 A:A:L46 13.15714.87YesNo098
62A:A:Q236 A:A:W281 10.44078.76NoYes185
63A:A:K233 A:A:Q236 20.69244.07YesNo198
64A:A:Q236 B:B:R314 10.410511.68NoYes188
65A:A:F290 A:A:T364 12.23567.78YesYes1999
66B:B:G319 B:B:M61 35.02893.49NoNo056
67B:B:G319 B:B:S277 24.1743.71NoNo055
68B:B:C233 B:B:S277 24.03456.89NoNo035
69B:B:C233 B:B:S191 23.89573.44NoNo038
70B:B:S191 B:B:V200 14.52843.23NoYes786
71B:B:G162 B:B:Y145 13.11288.69NoYes198
72B:B:G162 B:B:S161 24.2673.71NoNo199
73B:B:H142 B:B:S161 20.801916.74YesNo199
74B:B:H142 B:B:W169 16.85223.17YesYes198
75B:B:L139 B:B:W169 10.913317.08NoYes098
76B:B:I123 B:B:L139 10.42424.28YesNo069
77B:B:G319 B:B:L318 11.52063.42NoYes056
78R:R:F184 R:R:L159 21.43516.09YesNo089
79R:R:F187 R:R:L159 16.84116.09YesNo089
80R:R:F187 R:R:L183 16.72846.09YesNo089
81R:R:F187 R:R:N240 20.983214.5YesYes089
82R:R:F187 R:R:Q394 11.89217.03YesYes089
83R:R:N240 R:R:R190 15.309114.46YesYes098
84R:R:C236 R:R:R190 13.35044.18NoYes058
85R:R:C236 R:R:M233 12.68443.24NoNo656
86R:R:M233 R:R:Q234 12.35372.72NoYes667
87R:R:Q234 R:R:W284 10.02167.67YesYes678
88R:R:L244 R:R:N320 10.74614.12NoNo099
89R:R:L245 R:R:N320 10.15174.12NoNo089
90A:A:K233 B:B:M188 12.96427.2YesYes198
91B:B:D186 B:B:G162 11.64736.71YesNo199
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7RG9
Class B1
SubFamily Peptide
Type Glucagon
SubType GLP-1
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 3.2
Date 2022-04-13
D.O.I. 10.1073/pnas.2116506119
Net Summary
Imin 3.11
Number of Linked Nodes 826
Number of Links 993
Number of Hubs 149
Number of Links mediated by Hubs 551
Number of Communities 30
Number of Nodes involved in Communities 232
Number of Links involved in Communities 322
Path Summary
Number Of Nodes in MetaPath 92
Number Of Links MetaPath 91
Number of Shortest Paths 2888725
Length Of Smallest Path 3
Average Path Length 32.7814
Length of Longest Path 56
Minimum Path Strength 1.265
Average Path Strength 6.87654
Maximum Path Strength 26.02
Minimum Path Correlation 0.7
Average Path Correlation 0.987363
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.5641
Average % Of Corr. Nodes 41.267
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 42.5152
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • D1 dopamine receptor binding   • molecular function activator activity   • enzyme activator activity   • cyclase activator activity   • adenylate cyclase activator activity   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • protein localization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • cellular localization   • regulation of protein localization   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • localization   • regulation of cellular localization   • regulation of protein localization to cell cortex   • cellular macromolecule localization   • macromolecule localization   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • cellular response to nitrogen compound   • cellular response to peptide hormone stimulus   • response to glucagon   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • cognition   • developmental growth   • growth   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • homeostatic process   • adaptive thermogenesis   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • establishment of protein localization   • nitrogen compound transport   • regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • regulation of hormone secretion   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle
Gene OntologyCellular Component• midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle   • nuclear lumen   • cell periphery   • cell cortex   • cytoplasm   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • endomembrane system   • trans-Golgi network   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • glucagon receptor activity   • peptide receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • G protein-coupled peptide receptor activity   • signaling receptor activity   • transmembrane signaling receptor activity   • amide binding   • peptide hormone binding   • hormone binding   • glucagon-like peptide 1 receptor activity   • positive regulation of cytosolic calcium ion concentration   • regulation of biological quality   • heart process   • regulation of heart contraction   • regulation of system process   • circulatory system process   • regulation of blood circulation   • regulation of multicellular organismal process   • heart contraction   • blood circulation   • regulation of blood pressure   • positive regulation of blood pressure   • response to stress   • response to psychosocial stress   • cell surface receptor signaling pathway   • behavior   • learning or memory   • cognition   • transport   • secretion   • regulation of hormone levels   • export from cell   • hormone secretion   • establishment of localization   • localization   • secretion by cell   • signal release   • hormone transport   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • protein localization   • establishment of protein localization   • cellular localization   • nitrogen compound transport   • protein targeting   • protein transmembrane transport   • cellular macromolecule localization   • establishment of localization in cell   • post-translational protein targeting to membrane, translocation   • establishment of protein localization to endoplasmic reticulum   • protein localization to endoplasmic reticulum   • establishment of protein localization to membrane   • intracellular protein transmembrane transport   • intracellular transport   • post-translational protein targeting to endoplasmic reticulum membrane   • localization within membrane   • protein localization to membrane   • protein targeting to membrane   • transmembrane transport   • establishment of protein localization to organelle   • protein transport   • macromolecule localization   • protein localization to organelle   • intracellular protein transport   • protein targeting to ER   • negative regulation of blood pressure
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7RG9_Chain_A
LSAEDKAAV ERSKMIEKQ LQKDKQVYR ATHRLLLLG ASGKSTIVK 
QIFETKFQV DKVNFHMFD VGGQRDERR KWIQCFNDV TAIIFVVAS 
SSTNRLQEA LNLFKSIWN NRWLRTISV ILFLNKQDL LAEKVLAGK 
IEDYFPEFA RYTTPEDAT PEPGEDPRV TRAKYFIRD EFLRISTAS 
GDGRHYCYP HFTCDTENI RRVFNDCRD IIQRMHLRQ YELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7RG9_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7RG9_Chain_G
NTASIAQAR KLVEQLKME ANIDRIKVS KAAADLMAY CEAHAKEDP 
LLTPVPASE NPFRE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP43220
Sequence
>7RG9_Chain_R
EQLLFLYII YTVGYALSF SALVIASAI LLGFRHLHC TRNYIHLNL 
FASFILRAL SVFIKDAAL KWMYSTSYQ DSLSCRLVF LLMQYCVAA 
NYYWLLVEG VYLYTLLAF SVFSEQWIF RLYVSIGWG VPLLFVVPW 
GIVKYLYED EGCWTRNSN MNYWLIIRL PILFAIGVN FLIFVRVIC 
IVVSKLKAN LDIKCRLAK STLTLIPLL GTHEVIFAF VMDEHARGT 
LRFIKLFTE LSFTSFQGL MVAILYCFV NNEVQLEFR KSWERWR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9IVMB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)LSN3318839chim(NtGi1-Gs)/β2/γ23.222024-11-1310.1016/j.apsb.2024.09.002
8YW3B1PeptideGlucagonGLP-1Homo sapiensRetatrutide-Gs/β1/γ22.682024-09-18doi.org/10.1038/s41421-024-00700-0
8WG7B1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ22.542024-03-0610.1038/s41421-024-00649-0
8JISB1PeptideGlucagonGLP-1Homo sapiensPeptide-15-chim(NtGi1-Gs)/β1/γ22.462023-11-0810.1073/pnas.2303696120
8JIRB1PeptideGlucagonGLP-1Homo sapiensSAR425899-chim(NtGi1-Gs)/β1/γ22.572023-09-0610.1073/pnas.2303696120
8JIPB1PeptideGlucagonGLP-1Homo sapiensMEDI0382-chim(NtGi1-Gs)/β1/γ22.852023-09-0610.1073/pnas.2303696120
9IVGB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ232024-11-2710.1016/j.apsb.2024.09.002
9J1PB1PeptideGlucagonGLP-1Homo sapiensg1:Ox-chim(NtGi1-Gs)/β1/γ22.992025-02-2610.1021/jacs.4c12808
7X8SB1PeptideGlucagonGLP-1Homo sapiensWB4-24-Gs/β1/γ23.092022-06-2910.1073/pnas.2200155119
7X8RB1PeptideGlucagonGLP-1Homo sapiensBOC5-Gs/β1/γ22.612022-06-2910.1073/pnas.2200155119
7S15B1PeptideGlucagonGLP-1Homo sapiensPubChem 134611223--3.82022-06-0810.1021/acs.jmedchem.1c01856
7RGPB1PeptideGlucagonGLP-1Homo sapiensTirzepatide-chim(NtGi1-Gs)/β1/γ22.92022-04-1310.1073/pnas.2116506119
7RG9B1PeptideGlucagonGLP-1Homo sapiens--chim(NtGi1-Gs)/β1/γ23.22022-04-1310.1073/pnas.2116506119
7VBHB1PeptideGlucagonGLP-1Homo sapiensPeptide-20-Gs/β1/γ232022-04-0610.1038/s41467-022-28683-0
7VBIB1PeptideGlucagonGLP-1Homo sapiensNon-Acylated Tirzepatide-Gs/β1/γ232022-03-0210.1038/s41467-022-28683-0
7FIMB1PeptideGlucagonGLP-1Homo sapiensTirzepatide-Gs/β1/γ23.42022-03-0210.1038/s41467-022-28683-0
7LLYB1PeptideGlucagonGLP-1Homo sapiensOxyntomodulin-Gs/β1/γ23.32022-01-1210.1038/s41467-021-27760-0
7LLLB1PeptideGlucagonGLP-1Homo sapiensExendin-4-Gs/β1/γ23.72022-01-1210.1038/s41467-021-27760-0
7S3IB1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ22.512022-01-0510.1038/s41589-021-00945-w
7S1MB1PeptideGlucagonGLP-1Homo sapiensEx4-D-Ala-Gs/β1/γ22.412022-01-0510.1038/s41589-021-00945-w
7RTBB1PeptideGlucagonGLP-1Homo sapiensPeptide-19-Gs/β1/γ22.142021-10-0610.1016/j.bbrc.2021.09.016
7EVMB1PeptideGlucagonGLP-1Homo sapiens-PubChem 156022738Gs/β1/γ22.52021-08-1110.1038/s41467-021-24058-z
7DURB1PeptideGlucagonGLP-1Homo sapiens-PubChem 156022738Gs/β1/γ23.32021-08-1110.1038/s41467-021-24058-z
7KI1B1PeptideGlucagonGLP-1Homo sapiensTaspoglutide-Gs/β1/γ22.52021-08-0410.1016/j.celrep.2021.109374
7KI0B1PeptideGlucagonGLP-1Homo sapiensSemaglutide-Gs/β1/γ22.52021-08-0410.1016/j.celrep.2021.109374
7DUQB1PeptideGlucagonGLP-1Homo sapiensGLP-1PubChem 156022738Gs/β1/γ22.52021-07-1410.1038/s41467-021-24058-z
7E14B1PeptideGlucagonGLP-1Homo sapiensOrforglipronPubChem 156022738Gs/β1/γ22.92021-07-0710.1038/s41467-021-24058-z
7LCKB1PeptideGlucagonGLP-1Homo sapiensDanuglipron--3.242021-01-2010.1016/j.str.2021.04.008
7LCJB1PeptideGlucagonGLP-1Homo sapiensDanuglipron--2.822021-01-2010.1016/j.str.2021.04.008
7LCIB1PeptideGlucagonGLP-1Homo sapiensDanuglipron-Gs/β1/γ22.92021-01-2010.1016/j.str.2021.04.008
6XOXB1PeptideGlucagonGLP-1Homo sapiensOrforglipron-chim(NtGi1-Gs)/β1/γ23.12020-11-1810.1073/pnas.2014879117
6X1AB1PeptideGlucagonGLP-1Homo sapiensDanuglipron-Gs/β1/γ22.52020-09-0910.1016/j.molcel.2020.09.020
6X19B1PeptideGlucagonGLP-1Homo sapiensCHU-128-Gs/β1/γ22.12020-09-0910.1016/j.molcel.2020.09.020
6X18B1PeptideGlucagonGLP-1Homo sapiensGLP-1-Gs/β1/γ22.12020-09-0910.1016/j.molcel.2020.09.020
7C2EB1PeptideGlucagonGLP-1Homo sapiensPubChem 149050799-Gs/β1/γ24.22020-08-2610.1038/s41422-020-0384-8
6VCBB1PeptideGlucagonGLP-1Homo sapiensGLP-1LSN3160440Gs/β1/γ23.32020-07-2210.1038/s41589-020-0589-7
6LN2B1PeptideGlucagonGLP-1Homo sapiens-PubChem 68178630-3.22020-03-1810.1038/s41467-020-14934-5
6ORVB1PeptideGlucagonGLP-1Homo sapiens-TT-OAD2Gs/β1/γ232020-01-0810.1038/s41586-019-1902-z
6KK7B1PeptideGlucagonGLP-1Homo sapiens-PubChem 68178630-3.12019-11-1310.1107/S2052252519013496
6KK1B1PeptideGlucagonGLP-1Homo sapiens-PubChem 68178630-2.82019-11-1310.1107/S2052252519013496
6KJVB1PeptideGlucagonGLP-1Homo sapiens-PubChem 68178630-2.82019-11-1310.1107/S2052252519013496
6B3JB1PeptideGlucagonGLP-1Homo sapiensExendin-P5-Gs/β1/γ23.32018-02-2110.1038/nature25773
5NX2B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)--3.72017-06-1410.1038/nature22800
5VEWB1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-2.72017-05-2410.1038/nature22378
5VAIB1PeptideGlucagonGLP-1Oryctolagus cuniculusGLP-1-Gs/β1/γ24.12017-05-2410.1038/nature22394
5VEXB1PeptideGlucagonGLP-1Homo sapiens-NNC0640-32017-05-1710.1038/nature22378




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