Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Y37 9.3404
2A:A:S51 3.2965129
3A:A:K53 6.2945129
4A:A:F219 7.548577158
5A:A:H220 12.15754207
6A:A:F222 12.3325407
7A:A:K233 6.594589
8A:A:W234 6.44833619
9A:A:F238 9.9419
10A:A:F246 5.268509
11A:A:Y253 8.76254168
12A:A:N254 7.7054169
13A:A:F273 6.0785219
14A:A:W277 8.1085216
15A:A:W281 12.5767615
16A:A:F290 6.0085139
17A:A:N292 5.504509
18A:A:K293 5.045409
19A:A:L296 6.255406
20A:A:K300 6.0254169
21A:A:F312 5.3365178
22A:A:E314 4.6225176
23A:A:F315 13.1625406
24A:A:Y318 7.4675406
25A:A:P321 4.53565
26A:A:R336 7.0725405
27A:A:K338 9.9225465
28A:A:Y339 9.83463
29A:A:F340 10.6325177
30A:A:R342 7.406564
31A:A:E344 6.7225175
32A:A:F345 9.0425408
33A:A:R356 8.0725402
34A:A:Y358 7.772594
35A:A:Y360 10.265408
36A:A:F363 9.57565
37A:A:T364 6.85254139
38A:A:N371 6.0465139
39A:A:R373 5.4525405
40A:A:R374 6.4965134
41A:A:F376 9.41754158
42A:A:R385 9.675695
43B:B:L4 5.06404
44B:B:E12 4.855404
45B:B:R22 6.76426
46B:B:H54 11.9125409
47B:B:K57 12.474519
48B:B:Y59 9.8275418
49B:B:W63 7.852507
50B:B:W82 12.322559
51B:B:D83 9.9925458
52B:B:T86 7.5325456
53B:B:K89 5.77659
54B:B:H91 5.7375405
55B:B:I93 4.6375407
56B:B:W99 10.358519
57B:B:Y105 4.422867186
58B:B:V112 4.964188
59B:B:I123 3.8954266
60B:B:Y124 5.082506
61B:B:E138 3.12406
62B:B:H142 9.075419
63B:B:Y145 8.65518
64B:B:F151 5.54333609
65B:B:Q156 5.7525405
66B:B:D163 9.12419
67B:B:W169 9.10714718
68B:B:F180 8.876537
69B:B:H183 9.428539
70B:B:F199 9.33439
71B:B:C204 5.86487
72B:B:D205 7.385439
73B:B:K209 11.5725436
74B:B:W211 10.394538
75B:B:Q220 7.0475427
76B:B:H225 9.38833629
77B:B:D228 8.174589
78B:B:I232 5.475428
79B:B:F235 7.5145146
80B:B:P236 7.44754147
81B:B:F241 7.848526
82B:B:T243 6.6575428
83B:B:D246 7.2175489
84B:B:D247 9.3175429
85B:B:R251 11.38528
86B:B:F253 8.375426
87B:B:D258 10.32427
88B:B:M262 5.68404
89B:B:Y264 6.422505
90B:B:F278 5.7054147
91B:B:R283 7.1225109
92B:B:L284 4.7225405
93B:B:Y289 7.4717
94B:B:D290 7.6025416
95B:B:N295 10.5175416
96B:B:W297 7.0475418
97B:B:D298 8.4654109
98B:B:H311 9.356579
99B:B:R314 13.474518
100B:B:W332 10.1443719
101B:B:D333 8.8479
102B:B:K337 8.092576
103B:B:W339 9.192579
104G:G:V16 4.09754237
105G:G:A23 2.355408
106G:G:R27 5.96628
107G:G:Y40 12.564146
108G:G:D48 8.28409
109G:G:L51 5.368506
110G:G:N59 7.566549
111G:G:P60 7.1725449
112G:G:F61 5.2425848
113R:R:Y152 3.961676277
114R:R:L159 4.65409
115R:R:F169 7.3975407
116R:R:R176 4.604509
117R:R:L183 5.6725409
118R:R:F184 4.535408
119R:R:F187 8.7225408
120R:R:R190 5.7775408
121R:R:F230 9.28254305
122R:R:Y242 5.2725316
123R:R:W243 12.585299
124R:R:Y250 7.454508
125R:R:Y269 5.354507
126R:R:W284 7.723336308
127R:R:W297 11.59254118
128R:R:F321 3.8025406
129R:R:F324 7.1409
130R:R:K334 8.375499
131R:R:H363 10.4445328
132R:R:F404 4.2875408
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D83 B:B:T86 34.2248.67YesYes586
2B:B:N88 B:B:T86 34.71747.31NoYes576
3A:A:N23 B:B:N88 69.111913.62NoNo577
4A:A:N23 B:B:K89 69.18955.6NoYes579
5B:B:I80 B:B:K89 69.58754.36NoYes589
6B:B:H54 B:B:I80 78.887813.26YesNo098
7B:B:H54 B:B:S74 88.705916.74YesNo099
8B:B:D76 B:B:S74 88.80810.31NoNo099
9B:B:D76 B:B:L55 89.519512.21NoNo096
10A:A:Y37 B:B:L55 89.68194.69YesNo046
11A:A:R42 A:A:Y37 90.124422.64NoYes094
12A:A:F222 A:A:R42 90.22484.28YesNo079
13A:A:F222 B:B:W99 91.023422.05YesYes079
14B:B:Q75 B:B:W99 65.10375.48NoYes199
15B:B:K57 B:B:Q75 32.633113.56YesNo199
16B:B:K57 B:B:W332 32.513618.57YesYes199
17A:A:W281 B:B:W332 35.25788.43YesYes159
18A:A:W281 B:B:D290 66.3848.93YesYes156
19B:B:C271 B:B:D290 1006.22NoYes156
20B:B:C271 B:B:D291 81.33497.78NoNo158
21B:B:D291 B:B:N293 82.43184.04NoNo085
22B:B:A309 B:B:N293 82.18334.69NoNo035
23B:B:A309 R:R:R419 81.93464.15NoNo037
24R:R:K415 R:R:R419 81.68584.95NoNo077
25R:R:E412 R:R:K415 70.34268.1NoNo087
26R:R:E412 R:R:F169 70.526212.83NoYes087
27R:R:F169 R:R:F413 69.753711.79YesNo075
28R:R:F413 R:R:I165 69.49597.54NoNo058
29R:R:C403 R:R:I165 69.23816.55NoNo098
30R:R:A162 R:R:C403 65.09523.61NoNo099
31R:R:A162 R:R:F184 64.83524.16NoYes098
32R:R:F184 R:R:L159 64.05456.09YesYes089
33R:R:F187 R:R:L159 62.48973.65YesYes089
34R:R:F187 R:R:L183 21.3196.09YesYes089
35R:R:L183 R:R:S186 19.41384.5YesNo099
36R:R:S186 R:R:W243 38.45326.18NoYes099
37R:R:V246 R:R:W243 33.47114.9NoYes089
38R:R:V246 R:R:Y269 24.03313.79NoYes087
39B:B:Q75 B:B:Y59 32.490413.53NoYes198
40B:B:W332 B:B:Y59 37.18829.65YesYes198
41B:B:R314 B:B:W332 34.290716.99YesYes189
42B:B:D290 B:B:R314 34.094711.91YesYes168
43R:R:F187 R:R:N240 35.975218.12YesNo089
44R:R:N240 R:R:S186 19.64458.94NoNo099
45A:A:F238 B:B:W99 28.874710.02YesYes199
46A:A:F238 A:A:W234 28.90674.01YesYes199
47A:A:R231 A:A:W234 28.57899NoYes099
48A:A:L272 A:A:R231 28.376812.15NoNo089
49A:A:F246 A:A:L272 28.02117.31YesNo098
50A:A:F246 A:A:L289 34.13853.65YesNo099
51A:A:L289 A:A:L291 43.03526.92NoNo098
52A:A:F363 A:A:L291 42.89724.87YesNo058
53A:A:F363 A:A:Q294 53.501410.54YesNo656
54A:A:L297 A:A:Q294 53.70163.99NoNo086
55A:A:L297 A:A:S251 53.59573NoNo089
56A:A:L296 A:A:S251 53.48964.5YesNo069
57A:A:K293 A:A:L296 52.75478.46YesYes096
58A:A:K293 A:A:N292 52.21984.2YesYes099
59A:A:N292 A:A:T364 47.95765.85YesYes099
60A:A:R374 A:A:T364 18.19745.17YesYes1349
61A:A:F246 A:A:F273 13.48445.36YesYes099
62A:A:F273 A:A:F345 13.84717.5YesYes098
63A:A:F345 A:A:L289 12.88348.53YesNo089
64A:A:F273 A:A:W277 22.92576.01YesYes2196
65A:A:S349 A:A:W277 11.19586.18NoYes076
66A:A:H357 A:A:W277 33.550319.04NoYes076
67A:A:K280 A:A:W281 33.650122.05NoYes055
68A:A:K280 A:A:R283 33.62183.71NoNo053
69A:A:R283 A:A:R356 33.59396.4NoYes032
70A:A:H357 A:A:R356 33.52695.64NoYes072
71A:A:F290 A:A:T364 29.51349.08YesYes1399
72A:A:F290 A:A:I288 14.80193.77YesNo099
73A:A:D378 A:A:I288 14.54512.59NoNo079
74A:A:D378 A:A:Y360 43.233414.94NoYes078
75A:A:Y358 A:A:Y360 15.22054.96YesYes048
76A:A:F290 A:A:H362 14.66475.66YesNo1399
77A:A:D378 A:A:H362 29.084412.61NoNo079
78A:A:H362 A:A:R374 14.681814.67NoYes1394
79A:A:F363 A:A:R342 12.49156.41YesYes654
80A:A:C359 A:A:S349 11.10556.89NoNo057
81A:A:C359 A:A:P361 11.06283.77NoNo055
82A:A:P361 A:A:R342 11.04115.76NoYes654
83A:A:R385 A:A:Y358 13.627721.61YesYes954
84A:A:D381 A:A:Y360 26.818811.49NoYes088
85A:A:D381 A:A:R385 13.611511.91NoYes985
86A:A:D381 R:R:K334 12.812511.06NoYes989
87A:A:L394 A:A:R385 24.83243.64NoYes985
88A:A:L394 R:R:K334 12.48275.64NoYes989
89R:R:Y250 R:R:Y269 15.11746.95YesYes087
90A:A:Y391 R:R:Y250 10.64423.97NoYes048
91A:A:L388 A:A:L394 36.11338.3NoNo088
92A:A:L388 A:A:L393 32.5074.15NoNo088
93A:A:L393 R:R:L356 25.29114.15NoNo089
94B:B:D83 B:B:L69 68.57014.07YesNo085
95B:B:L69 B:B:Y105 69.07765.86NoYes056
96B:B:H62 B:B:Y105 57.2364.36NoYes066
97B:B:H62 B:B:R150 56.951420.31NoNo066
98B:B:C148 B:B:R150 56.66664.18NoNo066
99B:B:C148 B:B:L190 55.81164.76NoNo065
100B:B:L190 B:B:S160 55.52644.5NoNo056
101B:B:S160 B:B:V187 54.95564.85NoNo069
102B:B:C166 B:B:V187 49.6915.12NoNo089
103B:B:C166 B:B:F180 48.51174.19NoYes387
104B:B:F180 B:B:T178 47.89737.78YesNo374
105B:B:L168 B:B:T178 47.30845.9NoNo364
106B:B:L168 B:B:Q156 47.02865.32NoYes065
107B:B:Q156 B:B:R214 45.57815.84YesNo059
108B:B:R197 B:B:R214 44.99710.66NoNo059
109B:B:D195 B:B:R197 44.70635.96NoNo055
110B:B:A193 B:B:D195 44.41553.09NoNo045
111B:B:A193 B:B:F234 43.54225.55NoNo045
112B:B:F234 B:B:V200 42.667911.8NoNo056
113B:B:F241 B:B:V200 39.37077.87YesNo266
114B:B:F222 B:B:F241 36.99712.86NoYes286
115B:B:F222 B:B:Q220 36.86327.03NoYes287
116B:B:D258 B:B:Q220 22.410213.05YesYes277
117B:B:D258 B:B:R22 11.207613.1YesYes276
118B:B:I18 B:B:R22 10.0045.01NoYes276
119B:B:I18 G:G:A23 29.09463.25NoYes078
120B:B:L14 G:G:A23 26.37241.58NoYes088
121B:B:L14 G:G:K20 18.19912.82NoNo086
122G:G:K20 G:G:V16 16.38036.07NoYes2367
123B:B:L7 G:G:V16 13.65391.49NoYes087
124B:B:L7 B:B:Q6 11.8359.32NoNo081
125B:B:E3 B:B:Q6 10.925411.47NoNo051
126B:B:D258 G:G:R27 10.90459.53YesYes278
127B:B:I18 G:G:R27 19.99783.76NoYes278
128B:B:Q220 G:G:I25 11.20514.12YesNo272
129G:G:I25 G:G:R27 10.904711.27NoYes228
130B:B:E3 B:B:Q1 10.01563.82NoNo059
131B:B:C271 B:B:Y289 18.42554.03NoYes157
132B:B:W297 B:B:Y289 14.14425.79YesYes187
133B:B:W297 B:B:Y264 13.60546.75YesYes085
134B:B:M325 G:G:P49 10.11886.71NoNo057
135B:B:D312 R:R:K415 12.47966.91NoNo057
136B:B:D312 B:B:D333 12.60955.32NoYes059
137B:B:V112 B:B:Y105 10.40973.79YesYes1886
138B:B:L70 B:B:W82 17.8936.83NoYes059
139B:B:L70 B:B:W63 17.613112.53NoYes057
140B:B:T321 B:B:W63 10.251710.92NoYes077
141R:R:N240 R:R:R190 16.62739.64NoYes098
142R:R:R190 R:R:Y152 14.67724.12YesYes087
143R:R:V194 R:R:Y152 10.73983.79NoYes2777
144R:R:M233 R:R:V194 10.47793.04NoNo067
145R:R:F324 R:R:L356 21.68147.31YesNo099
146A:A:Q19 B:B:N88 34.289513.2NoNo547
147A:A:Q19 B:B:D83 34.166211.75NoYes548
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7S3I
Class B1
SubFamily Peptide
Type Glucagon
SubType GLP-1
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 2.51
Date 2022-01-05
D.O.I. 10.1038/s41589-021-00945-w
Net Summary
Imin 3.61
Number of Linked Nodes 854
Number of Links 981
Number of Hubs 132
Number of Links mediated by Hubs 503
Number of Communities 32
Number of Nodes involved in Communities 199
Number of Links involved in Communities 261
Path Summary
Number Of Nodes in MetaPath 148
Number Of Links MetaPath 147
Number of Shortest Paths 2419135
Length Of Smallest Path 3
Average Path Length 44.5211
Length of Longest Path 86
Minimum Path Strength 1.325
Average Path Strength 8.01458
Maximum Path Strength 23.52
Minimum Path Correlation 0.7
Average Path Correlation 0.985923
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.5641
Average % Of Corr. Nodes 36.7845
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 40.5673
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • molecular function activator activity   • phosphorus-oxygen lyase activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • adenylate cyclase activator activity   • adenylate cyclase activity   • cation binding   • metal ion binding   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development
Gene OntologyBiological Process• developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • cellular response to stimulus   • cellular response to nitrogen compound   • response to stimulus   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • cellular process   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • biological regulation   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • regulation of biological process   • regulation of cellular process   • signaling   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • positive regulation of cellular process   • protein localization   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • localization   • cellular macromolecule localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • intracellular anatomical structure   • cytoplasm   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • trans-Golgi network   • organelle membrane   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • glucagon receptor activity   • peptide receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • G protein-coupled peptide receptor activity   • signaling receptor activity   • transmembrane signaling receptor activity   • amide binding   • peptide hormone binding   • hormone binding   • glucagon-like peptide 1 receptor activity   • positive regulation of cytosolic calcium ion concentration   • regulation of biological quality   • heart process   • regulation of heart contraction   • regulation of system process   • circulatory system process   • regulation of blood circulation   • regulation of multicellular organismal process   • heart contraction   • blood circulation   • regulation of blood pressure   • positive regulation of blood pressure   • response to stress   • response to psychosocial stress   • cell surface receptor signaling pathway   • behavior   • learning or memory   • cognition   • transport   • secretion   • regulation of hormone levels   • export from cell   • hormone secretion   • establishment of localization   • localization   • secretion by cell   • signal release   • hormone transport   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • protein localization   • establishment of protein localization   • cellular localization   • nitrogen compound transport   • protein targeting   • protein transmembrane transport   • cellular macromolecule localization   • establishment of localization in cell   • post-translational protein targeting to membrane, translocation   • establishment of protein localization to endoplasmic reticulum   • protein localization to endoplasmic reticulum   • establishment of protein localization to membrane   • intracellular protein transmembrane transport   • intracellular transport   • post-translational protein targeting to endoplasmic reticulum membrane   • localization within membrane   • protein localization to membrane   • protein targeting to membrane   • transmembrane transport   • establishment of protein localization to organelle   • protein transport   • macromolecule localization   • protein localization to organelle   • intracellular protein transport   • protein targeting to ER   • negative regulation of blood pressure
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7S3I_Chain_A
TEDQRNEEK AQREANKKI EKQLQKDKQ VYRATHRLL LLGAGESGK 
NTIVKSGIF ETKFQVDKV NFHMFDVGA QRDERRKWI QCFNDVTAI 
IFVVASSSY NMTNRLQAA LKLFDSIWN NKWLRDTSV ILFLNKQDL 
LAEKVLAGK SKIEDYFPE FARYTTPED ATPEPGEDP RVTRAKYFI 
RDEFLRIST ASGDGRHYC YPHFTCSVD TENIRRVFN DCRDIIQRM 
HLRQYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7S3I_Chain_B
QSELDQLRQ EAEQLKNQI RDARKACAD ATLSQITNN IDPVGRIQM 
RTRRTLRGH LAKIYAMHW GTDSRLLVS ASQDGKLII WDSYTTNKV 
HAIPLRSSW VMTCAYAPS GNYVACGGL DNICSIYNL KTREGNVRV 
SRELAGHTG YLSCCRFLD DNQIVTSSG DTTCALWDI ETGQQTTTF 
TGHTGDVMS LSLAPDTRL FVSGACDAS AKLWDVREG MCRQTFTGH 
ESDINAICF FPNGNAFAT GSDDATCRL FDLRADQEL MTYSHDNII 
CGITSVSFS KSGRLLLAG YDDFNCNVW DALKADRAG VLAGHDNRV 
SCLGVTDDG MAVATGSWD SFLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7S3I_Chain_G
NTASIAQAR KLVEQLKME ANIDRIKVS KAAADLMAY CEAHAKEDP 
LLTPVPASE NPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP43220
Sequence
>7S3I_Chain_R
EEQLLFLYI IYTVGYALS FSALVIASA ILLGFRHLH CTRNYIHLN 
LFASFILRA LSVFIKDAA LKWMDSLSC RLVFLLMQY CVAANYYWL 
LVEGVYLYT LLAFSVFSE QWIFRLYVS IGWGVPLLF VVPWGIVKY 
LYEDEGCWT RNSNMNYWL IIRLPILFA IGVNFLIFV RVICIVVSK 
LKANTDIKC RLAKSTLTL IPLLGTHEV IFAFVMDEH ARGTLRFIK 
LFTELSFTS FQGLMVAIL YCFVNNEVQ LEFRKSWER WRL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9IVMB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)LSN3318839chim(NtGi1-Gs)/β2/γ23.222024-11-1310.1016/j.apsb.2024.09.002
9IVM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)LSN33188393.222024-11-1310.1016/j.apsb.2024.09.002
8YW3B1PeptideGlucagonGLP-1Homo sapiensRetatrutide-Gs/β1/γ22.682024-09-18doi.org/10.1038/s41421-024-00700-0
8YW3 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensRetatrutide-2.682024-09-18doi.org/10.1038/s41421-024-00700-0
8WG7B1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ22.542024-03-0610.1038/s41421-024-00649-0
8WG7 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--2.542024-03-0610.1038/s41421-024-00649-0
8JISB1PeptideGlucagonGLP-1Homo sapiensPeptide-15-chim(NtGi1-Gs)/β1/γ22.462023-11-0810.1073/pnas.2303696120
8JIS (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-15-2.462023-11-0810.1073/pnas.2303696120
8JIRB1PeptideGlucagonGLP-1Homo sapiensSAR425899-chim(NtGi1-Gs)/β1/γ22.572023-09-0610.1073/pnas.2303696120
8JIR (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensSAR425899-2.572023-09-0610.1073/pnas.2303696120
8JIPB1PeptideGlucagonGLP-1Homo sapiensMEDI0382-chim(NtGi1-Gs)/β1/γ22.852023-09-0610.1073/pnas.2303696120
8JIP (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensMEDI0382-2.852023-09-0610.1073/pnas.2303696120
9IVGB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ232024-11-2710.1016/j.apsb.2024.09.002
9IVG (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)-32024-11-2710.1016/j.apsb.2024.09.002
9J1PB1PeptideGlucagonGLP-1Homo sapiensg1:Ox-chim(NtGi1-Gs)/β1/γ22.992025-02-2610.1021/jacs.4c12808
9J1P (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensg1:Ox-2.992025-02-2610.1021/jacs.4c12808
7X8SB1PeptideGlucagonGLP-1Homo sapiensWB4-24-Gs/β1/γ23.092022-06-2910.1073/pnas.2200155119
7X8S (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensWB4-24-3.092022-06-2910.1073/pnas.2200155119
7X8RB1PeptideGlucagonGLP-1Homo sapiensBOC5-Gs/β1/γ22.612022-06-2910.1073/pnas.2200155119
7X8R (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensBOC5-2.612022-06-2910.1073/pnas.2200155119
7S15B1PeptideGlucagonGLP-1Homo sapiensPubChem 134611223--3.82022-06-0810.1021/acs.jmedchem.1c01856
7RGPB1PeptideGlucagonGLP-1Homo sapiensTirzepatide-chim(NtGi1-Gs)/β1/γ22.92022-04-1310.1073/pnas.2116506119
7RGP (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTirzepatide-2.92022-04-1310.1073/pnas.2116506119
7RG9B1PeptideGlucagonGLP-1Homo sapiens--chim(NtGi1-Gs)/β1/γ23.22022-04-1310.1073/pnas.2116506119
7RG9 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--3.22022-04-1310.1073/pnas.2116506119
7VBHB1PeptideGlucagonGLP-1Homo sapiensPeptide-20-Gs/β1/γ232022-04-0610.1038/s41467-022-28683-0
7VBH (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-20-32022-04-0610.1038/s41467-022-28683-0
7VBIB1PeptideGlucagonGLP-1Homo sapiensNon-Acylated Tirzepatide-Gs/β1/γ232022-03-0210.1038/s41467-022-28683-0
7VBI (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensNon-Acylated Tirzepatide-32022-03-0210.1038/s41467-022-28683-0
7FIMB1PeptideGlucagonGLP-1Homo sapiensTirzepatide-Gs/β1/γ23.42022-03-0210.1038/s41467-022-28683-0
7FIM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTirzepatide-3.42022-03-0210.1038/s41467-022-28683-0
7LLYB1PeptideGlucagonGLP-1Homo sapiensOxyntomodulin-Gs/β1/γ23.32022-01-1210.1038/s41467-021-27760-0
7LLY (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOxyntomodulin-3.32022-01-1210.1038/s41467-021-27760-0
7LLLB1PeptideGlucagonGLP-1Homo sapiensExendin-4-Gs/β1/γ23.72022-01-1210.1038/s41467-021-27760-0
7LLL (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-4-3.72022-01-1210.1038/s41467-021-27760-0
7S3IB1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ22.512022-01-0510.1038/s41589-021-00945-w
7S3I (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--2.512022-01-0510.1038/s41589-021-00945-w
7S1MB1PeptideGlucagonGLP-1Homo sapiensEx4-D-Ala-Gs/β1/γ22.412022-01-0510.1038/s41589-021-00945-w
7S1M (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensEx4-D-Ala-2.412022-01-0510.1038/s41589-021-00945-w
7RTBB1PeptideGlucagonGLP-1Homo sapiensPeptide-19-Gs/β1/γ22.142021-10-0610.1016/j.bbrc.2021.09.016
7RTB (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-19-2.142021-10-0610.1016/j.bbrc.2021.09.016
7EVMB1PeptideGlucagonGLP-1Homo sapiens-PubChem 156022738Gs/β1/γ22.52021-08-1110.1038/s41467-021-24058-z
7EVM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-PubChem 1560227382.52021-08-1110.1038/s41467-021-24058-z
7DURB1PeptideGlucagonGLP-1Homo sapiens-PubChem 156022738Gs/β1/γ23.32021-08-1110.1038/s41467-021-24058-z
7DUR (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-PubChem 1560227383.32021-08-1110.1038/s41467-021-24058-z
7KI1B1PeptideGlucagonGLP-1Homo sapiensTaspoglutide-Gs/β1/γ22.52021-08-0410.1016/j.celrep.2021.109374
7KI1 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTaspoglutide-2.52021-08-0410.1016/j.celrep.2021.109374
7KI0B1PeptideGlucagonGLP-1Homo sapiensSemaglutide-Gs/β1/γ22.52021-08-0410.1016/j.celrep.2021.109374
7KI0 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensSemaglutide-2.52021-08-0410.1016/j.celrep.2021.109374
7DUQB1PeptideGlucagonGLP-1Homo sapiensGLP-1PubChem 156022738Gs/β1/γ22.52021-07-1410.1038/s41467-021-24058-z
7DUQ (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1PubChem 1560227382.52021-07-1410.1038/s41467-021-24058-z
7E14B1PeptideGlucagonGLP-1Homo sapiensOrforglipronPubChem 156022738Gs/β1/γ22.92021-07-0710.1038/s41467-021-24058-z
7E14 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOrforglipronPubChem 1560227382.92021-07-0710.1038/s41467-021-24058-z
7LCKB1PeptideGlucagonGLP-1Homo sapiensDanuglipron--3.242021-01-2010.1016/j.str.2021.04.008
7LCJB1PeptideGlucagonGLP-1Homo sapiensDanuglipron--2.822021-01-2010.1016/j.str.2021.04.008
7LCIB1PeptideGlucagonGLP-1Homo sapiensDanuglipron-Gs/β1/γ22.92021-01-2010.1016/j.str.2021.04.008
7LCI (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensDanuglipron-2.92021-01-2010.1016/j.str.2021.04.008
6XOXB1PeptideGlucagonGLP-1Homo sapiensOrforglipron-chim(NtGi1-Gs)/β1/γ23.12020-11-1810.1073/pnas.2014879117
6XOX (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOrforglipron-3.12020-11-1810.1073/pnas.2014879117
6X1AB1PeptideGlucagonGLP-1Homo sapiensDanuglipron-Gs/β1/γ22.52020-09-0910.1016/j.molcel.2020.09.020
6X1A (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensDanuglipron-2.52020-09-0910.1016/j.molcel.2020.09.020
6X19B1PeptideGlucagonGLP-1Homo sapiensCHU-128-Gs/β1/γ22.12020-09-0910.1016/j.molcel.2020.09.020
6X19 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensCHU-128-2.12020-09-0910.1016/j.molcel.2020.09.020
6X18B1PeptideGlucagonGLP-1Homo sapiensGLP-1-Gs/β1/γ22.12020-09-0910.1016/j.molcel.2020.09.020
6X18 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1-2.12020-09-0910.1016/j.molcel.2020.09.020
7C2EB1PeptideGlucagonGLP-1Homo sapiensPubChem 149050799-Gs/β1/γ24.22020-08-2610.1038/s41422-020-0384-8
7C2E (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPubChem 149050799-4.22020-08-2610.1038/s41422-020-0384-8
6VCBB1PeptideGlucagonGLP-1Homo sapiensGLP-1LSN3160440Gs/β1/γ23.32020-07-2210.1038/s41589-020-0589-7
6VCB (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1LSN31604403.32020-07-2210.1038/s41589-020-0589-7
6LN2B1PeptideGlucagonGLP-1Homo sapiens-PubChem 68178630-3.22020-03-1810.1038/s41467-020-14934-5
6ORVB1PeptideGlucagonGLP-1Homo sapiens-TT-OAD2Gs/β1/γ232020-01-0810.1038/s41586-019-1902-z
6ORV (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-TT-OAD232020-01-0810.1038/s41586-019-1902-z
6KK7B1PeptideGlucagonGLP-1Homo sapiens-PubChem 68178630-3.12019-11-1310.1107/S2052252519013496
6KK1B1PeptideGlucagonGLP-1Homo sapiens-PubChem 68178630-2.82019-11-1310.1107/S2052252519013496
6KJVB1PeptideGlucagonGLP-1Homo sapiens-PubChem 68178630-2.82019-11-1310.1107/S2052252519013496
6B3JB1PeptideGlucagonGLP-1Homo sapiensExendin-P5-Gs/β1/γ23.32018-02-2110.1038/nature25773
6B3J (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-P5-3.32018-02-2110.1038/nature25773
5NX2B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)--3.72017-06-1410.1038/nature22800
5VEWB1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-2.72017-05-2410.1038/nature22378
5VAIB1PeptideGlucagonGLP-1Oryctolagus cuniculusGLP-1-Gs/β1/γ24.12017-05-2410.1038/nature22394
5VAI (No Gprot) B1PeptideGlucagonGLP-1Oryctolagus cuniculusGLP-1-4.12017-05-2410.1038/nature22394
5VEXB1PeptideGlucagonGLP-1Homo sapiens-NNC0640-32017-05-1710.1038/nature22378




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7S3I.zip



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