psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:G4	L:L:H1	4.77	No	Yes	0	0	0
2	L:L:H1	R:R:Q234	6.18	Yes	Yes	4	0	7
3	L:L:H1	R:R:V237	15.22	Yes	No	0	0	6
4	L:L:H1	R:R:W306	7.41	Yes	Yes	4	0	6
5	L:L:S2	R:R:E387	7.19	No	No	0	0	8
6	L:L:S2	R:R:L388	6.01	No	Yes	0	0	7
7	L:L:Q3	R:R:Y148	5.64	Yes	Yes	2	0	7
8	L:L:Q3	R:R:Y152	3.38	Yes	Yes	2	0	7
9	L:L:Q3	R:R:V194	5.73	Yes	No	2	0	7
10	L:L:Q3	R:R:K197	4.07	Yes	Yes	0	0	6
11	L:L:Q3	R:R:L388	3.99	Yes	Yes	2	0	7
12	L:L:T5	R:R:E373	9.88	No	Yes	0	0	4
13	L:L:T5	R:R:L384	5.9	No	No	0	0	5
14	L:L:F6	R:R:L141	3.65	Yes	No	0	0	5
15	L:L:F6	R:R:L144	4.87	Yes	No	2	0	6
16	L:L:F6	R:R:Y148	8.25	Yes	Yes	2	0	7
17	L:L:F6	R:R:L388	4.87	Yes	Yes	2	0	7
18	L:L:T7	R:R:K197	9.01	No	Yes	0	0	6
19	L:L:S8	R:R:N300	7.45	No	No	0	0	6
20	L:L:D9	R:R:R380	8.34	No	No	0	0	5
21	L:L:L14	L:L:Y10	10.55	No	No	0	0	0
22	L:L:Y10	R:R:L201	3.52	No	No	0	0	7
23	L:L:Y10	R:R:K202	7.17	No	No	0	0	4
24	L:L:S11	R:R:T298	6.4	No	No	3	0	5
25	L:L:S11	R:R:R299	9.22	No	Yes	3	0	4
26	L:L:K12	R:R:R299	6.19	No	Yes	0	0	4
27	L:L:Q17	L:L:Y13	10.15	No	No	0	0	0
28	L:L:L14	L:L:Q17	5.32	No	No	0	0	0
29	L:L:L14	R:R:Y205	5.86	No	Yes	0	0	3
30	L:L:D15	R:R:Y205	8.05	No	Yes	0	0	3
31	L:L:E16	R:R:V30	11.41	No	No	0	0	2
32	L:L:E21	R:R:A209	4.53	No	No	0	0	1
33	L:L:E21	R:R:W214	6.54	No	Yes	0	0	1
34	L:L:F22	L:L:I23	6.28	Yes	Yes	0	0	0
35	L:L:F22	L:L:W25	4.01	Yes	No	1	0	0
36	L:L:F22	L:L:L26	7.31	Yes	No	1	0	0
37	L:L:F22	R:R:V36	11.8	Yes	No	0	0	2
38	L:L:F22	R:R:W214	11.02	Yes	Yes	1	0	1
39	L:L:I23	L:L:M27	4.37	Yes	No	0	0	0
40	L:L:I23	R:R:W91	3.52	Yes	No	0	0	4
41	L:L:L26	L:L:W25	6.83	No	No	1	0	0
42	L:L:W25	R:R:W214	23.43	No	Yes	1	0	1
43	L:L:L26	R:R:W39	13.67	No	Yes	1	0	5
44	L:L:M27	R:R:Y88	7.18	No	Yes	1	0	5
45	L:L:M27	R:R:L89	4.24	No	Yes	1	0	5
46	R:R:E34	R:R:S31	11.5	No	No	0	4	4
47	R:R:Q37	R:R:W33	4.38	No	No	0	4	3
48	R:R:L218	R:R:W33	9.11	No	No	0	3	3
49	R:R:E34	R:R:T35	4.23	No	Yes	1	4	5
50	R:R:E34	R:R:K38	8.1	No	Yes	1	4	4
51	R:R:K38	R:R:T35	6.01	Yes	Yes	1	4	5
52	R:R:P90	R:R:T35	3.5	No	Yes	0	4	5
53	R:R:K38	R:R:Q37	5.42	Yes	No	0	4	4
54	R:R:K38	R:R:Y88	9.55	Yes	Yes	1	4	5
55	R:R:R40	R:R:W39	13	No	Yes	0	2	5
56	R:R:R43	R:R:W39	14.99	Yes	Yes	1	4	5
57	R:R:E68	R:R:W39	7.63	Yes	Yes	1	4	5
58	R:R:W39	R:R:Y88	4.82	Yes	Yes	1	5	5
59	R:R:D215	R:R:R40	5.96	No	No	0	3	2
60	R:R:E41	R:R:Y42	4.49	No	Yes	1	4	6
61	R:R:E41	R:R:R44	11.63	No	No	0	4	3
62	R:R:E41	R:R:W87	5.45	No	No	1	4	3
63	R:R:R43	R:R:Y42	4.12	Yes	Yes	1	4	6
64	R:R:Q45	R:R:Y42	10.15	No	Yes	1	5	6
65	R:R:P86	R:R:Y42	4.17	No	Yes	0	8	6
66	R:R:W87	R:R:Y42	19.29	No	Yes	1	3	6
67	R:R:Y42	R:R:Y88	15.89	Yes	Yes	1	6	5
68	R:R:C46	R:R:R43	5.57	No	Yes	0	8	4
69	R:R:E68	R:R:R43	5.82	Yes	Yes	1	4	4
70	R:R:Q45	R:R:R48	4.67	No	No	0	5	4
71	R:R:Q45	R:R:W87	7.67	No	No	1	5	3
72	R:R:C46	R:R:F66	6.98	No	No	0	8	7
73	R:R:C46	R:R:C71	7.28	No	No	0	8	9
74	R:R:L50	R:R:Q47	3.99	No	No	0	4	3
75	R:R:R48	R:R:S49	3.95	No	No	0	4	2
76	R:R:C71	R:R:S49	6.89	No	No	0	9	2
77	R:R:D74	R:R:P54	6.44	Yes	No	0	3	2
78	R:R:A57	R:R:P77	3.74	No	Yes	0	1	4
79	R:R:D59	R:R:T58	8.67	No	No	0	3	1
80	R:R:P77	R:R:T58	8.74	Yes	No	0	4	1
81	R:R:D59	R:R:L60	4.07	No	No	0	3	1
82	R:R:G108	R:R:L60	5.13	No	No	0	9	1
83	R:R:F61	R:R:N63	7.25	No	No	9	3	4
84	R:R:D74	R:R:F61	5.97	Yes	No	9	3	3
85	R:R:C104	R:R:C62	7.28	No	No	0	9	9
86	R:R:N63	R:R:W72	3.39	No	Yes	0	4	9
87	R:R:D74	R:R:N63	14.81	Yes	No	9	3	4
88	R:R:R64	R:R:W72	13	No	Yes	0	4	9
89	R:R:R64	R:R:W110	34.99	No	Yes	0	4	9
90	R:R:F66	R:R:W72	10.02	No	Yes	0	7	9
91	R:R:D67	R:R:E68	3.9	No	Yes	1	9	4
92	R:R:D67	R:R:Y69	3.45	No	No	1	9	6
93	R:R:E68	R:R:Y69	3.37	Yes	No	1	4	6
94	R:R:P73	R:R:W72	4.05	No	Yes	0	5	9
95	R:R:P73	R:R:V83	7.07	No	No	0	5	5
96	R:R:E76	R:R:P77	6.29	No	Yes	0	1	4
97	R:R:F80	R:R:N82	15.71	No	No	0	4	4
98	R:R:F80	R:R:Y101	6.19	No	Yes	0	4	5
99	R:R:F103	R:R:F80	15	No	No	0	4	4
100	R:R:H99	R:R:N82	12.75	No	No	0	4	4
101	R:R:V100	R:R:V83	3.21	No	No	10	7	5
102	R:R:R102	R:R:V83	6.54	No	No	10	8	5
103	R:R:C85	R:R:P86	3.77	Yes	No	0	9	8
104	R:R:C126	R:R:C85	5.46	No	Yes	0	9	9
105	R:R:L89	R:R:P86	8.21	Yes	No	0	5	8
106	R:R:L89	R:R:Y88	11.72	Yes	Yes	1	5	5
107	R:R:L89	R:R:P90	3.28	Yes	No	0	5	4
108	R:R:L89	R:R:W91	3.42	Yes	No	0	5	4
109	R:R:E127	R:R:W91	14.17	No	No	0	2	4
110	R:R:Q97	R:R:V95	4.3	No	No	0	4	5
111	R:R:P96	R:R:Q97	7.9	No	No	0	3	4
112	R:R:E125	R:R:G98	3.27	No	No	0	5	4
113	R:R:H99	R:R:Y101	28.31	No	Yes	0	4	5
114	R:R:R102	R:R:V100	15.69	No	No	10	8	7
115	R:R:D122	R:R:Y101	11.49	No	Yes	11	7	5
116	R:R:E125	R:R:Y101	11.22	No	Yes	11	5	5
117	R:R:R102	R:R:W110	12	No	Yes	0	8	9
118	R:R:F103	R:R:W120	4.01	No	No	0	4	5
119	R:R:C104	R:R:E107	4.56	No	Yes	0	9	5
120	R:R:C104	R:R:W110	6.53	No	Yes	0	9	9
121	R:R:E107	R:R:T105	4.23	Yes	No	0	5	4
122	R:R:E107	R:R:G108	3.27	Yes	No	0	5	9
123	R:R:E107	R:R:L109	9.28	Yes	No	0	5	5
124	R:R:L109	R:R:Q112	3.99	No	No	0	5	3
125	R:R:Q112	R:R:W110	5.48	No	Yes	0	3	9
126	R:R:P119	R:R:W110	4.05	No	Yes	0	6	9
127	R:R:L111	R:R:W120	6.83	No	No	0	4	5
128	R:R:K113	R:R:L118	5.64	No	No	0	4	4
129	R:R:L123	R:R:R121	15.79	No	No	0	5	6
130	R:R:D122	R:R:E125	12.99	No	No	11	7	5
131	R:R:E139	R:R:P137	3.14	No	No	0	2	3
132	R:R:F381	R:R:Q140	11.71	No	No	0	4	4
133	R:R:F143	R:R:I147	7.54	No	No	0	4	6
134	R:R:F143	R:R:F381	3.22	No	No	0	4	4
135	R:R:F381	R:R:L144	7.31	No	No	0	4	6
136	R:R:L144	R:R:L388	4.15	No	Yes	2	6	7
137	R:R:Y145	R:R:Y148	4.96	No	Yes	2	5	7
138	R:R:D198	R:R:Y145	10.34	No	No	2	7	5
139	R:R:I147	R:R:S389	4.64	No	No	0	6	5
140	R:R:Y148	R:R:Y152	4.96	Yes	Yes	2	7	7
141	R:R:D198	R:R:Y148	8.05	No	Yes	2	7	7
142	R:R:L388	R:R:Y148	8.21	Yes	Yes	2	7	7
143	R:R:G151	R:R:V150	3.68	Yes	No	0	8	5
144	R:R:G151	R:R:S392	3.71	Yes	No	2	8	9
145	R:R:F393	R:R:G151	9.03	No	Yes	2	7	8
146	R:R:R190	R:R:Y152	11.32	Yes	Yes	0	8	7
147	R:R:A191	R:R:Y152	5.34	No	Yes	0	7	7
148	R:R:V194	R:R:Y152	10.09	No	Yes	2	7	7
149	R:R:S392	R:R:Y152	6.36	No	Yes	2	9	7
150	R:R:G395	R:R:S155	3.71	No	No	0	9	9
151	R:R:F156	R:R:V160	3.93	No	No	0	7	3
152	R:R:F156	R:R:I188	5.02	No	No	0	7	7
153	R:R:F156	R:R:L192	7.31	No	No	0	7	3
154	R:R:F184	R:R:L159	4.87	No	Yes	0	8	9
155	R:R:F187	R:R:L159	4.87	Yes	Yes	0	8	9
156	R:R:I188	R:R:L159	4.28	No	Yes	0	7	9
157	R:R:A399	R:R:L159	3.15	No	Yes	0	8	9
158	R:R:A162	R:R:C403	3.61	No	No	0	9	9
159	R:R:C403	R:R:I165	3.27	No	No	0	9	8
160	R:R:F413	R:R:I165	6.28	No	No	0	5	8
161	R:R:L166	R:R:N177	6.87	Yes	Yes	0	8	9
162	R:R:L166	R:R:L181	6.92	Yes	No	0	8	6
163	R:R:F184	R:R:L166	4.87	No	Yes	0	8	8
164	R:R:C403	R:R:L166	3.17	No	Yes	0	9	8
165	R:R:L167	R:R:L181	5.54	No	No	0	3	6
166	R:R:F169	R:R:L172	4.87	Yes	No	0	7	9
167	R:R:E412	R:R:F169	13.99	No	Yes	0	8	7
168	R:R:F169	R:R:F413	10.72	Yes	No	0	7	5
169	R:R:E412	R:R:H171	12.31	No	No	0	8	7
170	R:R:H173	R:R:Y178	6.53	No	No	0	7	6
171	R:R:C174	R:R:R176	5.57	No	Yes	7	8	9
172	R:R:C174	R:R:N177	4.72	No	Yes	7	8	9
173	R:R:N177	R:R:R176	6.03	Yes	Yes	7	9	9
174	R:R:H180	R:R:R176	3.39	Yes	Yes	7	9	9
175	R:R:E408	R:R:R176	5.82	No	Yes	0	9	9
176	R:R:H180	R:R:N177	3.83	Yes	Yes	7	9	9
177	R:R:F266	R:R:Y178	6.19	No	No	0	6	6
178	R:R:I179	R:R:W243	4.7	No	Yes	0	8	9
179	R:R:E247	R:R:I179	5.47	No	No	0	9	8
180	R:R:F266	R:R:I179	3.77	No	No	0	6	8
181	R:R:E247	R:R:H180	9.85	No	Yes	0	9	9
182	R:R:H180	R:R:Y402	5.44	Yes	No	0	9	8
183	R:R:N182	R:R:W243	15.82	No	Yes	12	9	9
184	R:R:N182	R:R:W274	5.65	No	Yes	12	9	9
185	R:R:F187	R:R:L183	6.09	Yes	No	0	8	9
186	R:R:L183	R:R:L244	4.15	No	No	0	9	9
187	R:R:F184	R:R:V398	3.93	No	No	0	8	9
188	R:R:N240	R:R:S186	7.45	No	No	0	9	9
189	R:R:S186	R:R:W243	7.41	No	Yes	0	9	9
190	R:R:F187	R:R:N240	16.92	Yes	No	0	8	9
191	R:R:F187	R:R:Q394	10.54	Yes	Yes	0	8	9
192	R:R:F187	R:R:G395	6.02	Yes	No	0	8	9
193	R:R:C236	R:R:L189	4.76	No	No	0	5	7
194	R:R:R190	R:R:V237	14.38	Yes	No	0	8	6
195	R:R:N240	R:R:R190	10.85	No	Yes	0	9	8
196	R:R:R190	R:R:Y241	8.23	Yes	Yes	0	8	8
197	R:R:R190	R:R:T391	6.47	Yes	No	0	8	6
198	R:R:L232	R:R:S193	4.5	No	No	13	5	6
199	R:R:C236	R:R:S193	5.16	No	No	13	5	6
200	R:R:D198	R:R:K197	12.44	No	Yes	0	7	6
201	R:R:F230	R:R:K197	4.96	No	Yes	0	5	6
202	R:R:K197	R:R:M233	7.2	Yes	No	0	6	6
203	R:R:T207	R:R:W203	7.28	No	No	0	3	3
204	R:R:M204	R:R:Y205	9.58	Yes	Yes	3	3	3
205	R:R:M204	R:R:Q221	6.8	Yes	No	3	3	4
206	R:R:C226	R:R:M204	3.24	No	Yes	3	9	3
207	R:R:C296	R:R:M204	6.48	No	Yes	3	9	3
208	R:R:Q221	R:R:Y205	3.38	No	Yes	3	4	3
209	R:R:R299	R:R:Y205	3.09	Yes	Yes	3	4	3
210	R:R:A208	R:R:L217	4.73	No	Yes	0	4	4
211	R:R:H212	R:R:Q210	4.95	No	No	0	3	4
212	R:R:Q211	R:R:Q213	14.08	No	No	0	4	4
213	R:R:G216	R:R:Q213	4.93	No	No	0	2	4
214	R:R:L217	R:R:W214	3.42	Yes	Yes	0	4	1
215	R:R:G216	R:R:S219	3.71	No	No	0	2	5
216	R:R:L217	R:R:L218	5.54	Yes	No	0	4	3
217	R:R:L217	R:R:Q221	3.99	Yes	No	0	4	4
218	R:R:D222	R:R:S219	4.42	No	No	0	6	5
219	R:R:S223	R:R:Y220	3.82	No	No	0	4	3
220	R:R:C226	R:R:Y220	9.41	No	No	0	9	3
221	R:R:S223	R:R:S225	3.26	No	No	0	4	3
222	R:R:L224	R:R:L228	4.15	No	No	0	3	4
223	R:R:C226	R:R:C296	7.28	No	No	3	9	9
224	R:R:D293	R:R:R227	10.72	No	No	8	7	8
225	R:R:R227	R:R:W297	18.99	No	Yes	8	8	8
226	R:R:F230	R:R:T298	7.78	No	No	0	5	5
227	R:R:L231	R:R:W297	6.83	No	Yes	0	5	8
228	R:R:C236	R:R:L232	3.17	No	No	13	5	5
229	R:R:M233	R:R:Q234	5.44	No	Yes	0	6	7
230	R:R:Q234	R:R:W284	12.05	Yes	Yes	4	7	8
231	R:R:Q234	R:R:W306	4.38	Yes	Yes	4	7	6
232	R:R:I309	R:R:Q234	6.86	No	Yes	4	7	7
233	R:R:W274	R:R:Y235	7.72	Yes	No	0	9	9
234	R:R:L278	R:R:Y235	5.86	No	No	0	3	9
235	R:R:V281	R:R:Y235	3.79	No	No	0	6	9
236	R:R:I313	R:R:Y241	12.09	No	Yes	0	7	8
237	R:R:I317	R:R:Y241	4.84	No	Yes	5	7	8
238	R:R:E364	R:R:Y241	10.1	Yes	Yes	5	8	8
239	R:R:V276	R:R:Y242	7.57	No	Yes	6	3	6
240	R:R:P277	R:R:Y242	6.95	No	Yes	6	9	6
241	R:R:F280	R:R:Y242	7.22	No	Yes	6	5	6
242	R:R:P312	R:R:Y242	4.17	No	Yes	6	8	6
243	R:R:A316	R:R:Y242	4	No	Yes	0	7	6
244	R:R:V246	R:R:W243	4.9	No	Yes	0	8	9
245	R:R:G273	R:R:W243	8.44	No	Yes	0	9	9
246	R:R:W243	R:R:W274	25.3	Yes	Yes	12	9	9
247	R:R:L244	R:R:Q394	6.65	No	Yes	0	9	9
248	R:R:A316	R:R:L245	3.15	No	No	0	7	8
249	R:R:V246	R:R:Y269	5.05	No	Yes	0	8	7
250	R:R:E247	R:R:L359	10.6	No	No	0	9	9
251	R:R:G248	R:R:I323	3.53	No	No	0	8	8
252	R:R:T253	R:R:Y250	3.75	No	Yes	14	7	8
253	R:R:L254	R:R:Y250	12.89	No	Yes	0	8	8
254	R:R:Y250	R:R:Y269	6.95	Yes	Yes	14	8	7
255	R:R:L251	R:R:V327	4.47	No	No	0	9	9
256	R:R:R326	R:R:Y252	3.09	No	No	0	8	8
257	R:R:T253	R:R:Y269	4.99	No	Yes	14	7	7
258	R:R:F257	R:R:S258	6.61	No	No	0	5	7
259	R:R:L260	R:R:W264	4.56	No	No	0	7	5
260	R:R:S261	R:R:W264	4.94	No	No	0	7	5
261	R:R:Q263	R:R:R267	18.69	No	No	0	5	4
262	R:R:I265	R:R:Y269	6.04	No	Yes	0	5	7
263	R:R:F266	R:R:V270	7.87	No	No	0	6	5
264	R:R:I272	R:R:L268	5.71	No	No	0	6	2
265	R:R:G273	R:R:I272	3.53	No	No	0	9	6
266	R:R:I272	R:R:V276	4.61	No	No	0	6	3
267	R:R:P277	R:R:V276	3.53	No	No	6	9	3
268	R:R:F280	R:R:P312	18.78	No	No	6	5	8
269	R:R:P283	R:R:V282	3.53	No	No	0	5	3
270	R:R:G285	R:R:W284	4.22	No	Yes	0	5	8
271	R:R:K288	R:R:W284	18.57	No	Yes	0	8	8
272	R:R:I308	R:R:W284	5.87	No	Yes	0	8	8
273	R:R:I309	R:R:W284	12.92	No	Yes	4	7	8
274	R:R:V287	R:R:Y291	3.79	No	No	0	4	3
275	R:R:V287	R:R:Y305	8.83	No	No	0	4	4
276	R:R:E292	R:R:K288	14.85	No	No	0	6	8
277	R:R:K288	R:R:W297	16.24	No	Yes	0	8	8
278	R:R:D293	R:R:Y289	8.05	No	Yes	8	7	3
279	R:R:W297	R:R:Y289	4.82	Yes	Yes	8	8	3
280	R:R:L290	R:R:Y291	10.55	No	No	0	3	3
281	R:R:E292	R:R:E294	13.95	No	No	15	6	4
282	R:R:E292	R:R:S301	5.75	No	No	15	6	3
283	R:R:D293	R:R:W297	6.7	No	Yes	8	7	8
284	R:R:E294	R:R:S301	8.62	No	No	15	4	3
285	R:R:R299	R:R:T298	5.17	Yes	No	3	4	5
286	R:R:N300	R:R:W306	20.34	No	Yes	0	6	6
287	R:R:N302	R:R:N304	4.09	No	No	0	5	3
288	R:R:N302	R:R:Y305	16.28	No	No	0	5	4
289	R:R:E373	R:R:M303	10.83	Yes	No	0	4	5
290	R:R:R310	R:R:W306	17.99	Yes	Yes	4	6	6
291	R:R:E373	R:R:W306	6.54	Yes	Yes	4	4	6
292	R:R:L307	R:R:R310	8.5	No	Yes	0	7	6
293	R:R:L307	R:R:L311	4.15	No	No	0	7	4
294	R:R:D372	R:R:R310	3.57	No	Yes	0	5	6
295	R:R:E373	R:R:R310	5.82	Yes	Yes	4	4	6
296	R:R:F369	R:R:L314	7.31	Yes	No	0	4	4
297	R:R:F315	R:R:V319	5.24	No	No	0	4	6
298	R:R:E364	R:R:I317	6.83	Yes	No	5	8	7
299	R:R:F369	R:R:I317	6.28	Yes	No	0	4	7
300	R:R:L360	R:R:N320	8.24	No	No	0	9	9
301	R:R:F321	R:R:V365	9.18	No	No	0	6	6
302	R:R:F324	R:R:I328	5.02	No	No	0	9	7
303	R:R:F324	R:R:L356	3.65	No	No	0	9	9
304	R:R:F324	R:R:T362	9.08	No	No	0	9	7
305	R:R:I330	R:R:R326	7.52	No	No	0	9	8
306	R:R:I328	R:R:T353	6.08	No	No	0	7	9
307	R:R:S352	R:R:V331	3.23	No	No	0	9	8
308	R:R:L335	R:R:N338	6.87	No	No	0	8	6
309	R:R:I345	R:R:L335	4.28	No	No	0	5	8
310	R:R:L335	R:R:R348	4.86	No	No	0	8	8
311	R:R:I345	R:R:K336	8.72	No	No	0	5	6
312	R:R:K342	R:R:M340	4.32	No	No	16	5	5
313	R:R:D344	R:R:M340	5.54	No	No	16	7	5
314	R:R:D344	R:R:K342	13.83	No	No	16	7	5
315	R:R:K351	R:R:R348	6.19	No	No	0	8	8
316	R:R:R348	R:R:S352	6.59	No	No	0	8	9
317	R:R:L401	R:R:T355	4.42	No	No	0	8	8
318	R:R:L356	R:R:L360	5.54	No	No	0	9	9
319	R:R:I357	R:R:P358	3.39	No	No	0	8	9
320	R:R:I357	R:R:T362	6.08	No	No	0	8	7
321	R:R:L359	R:R:Y402	21.1	No	No	0	9	8
322	R:R:G361	R:R:H363	3.18	No	Yes	5	9	8
323	R:R:G361	R:R:Q394	3.29	No	Yes	5	9	9
324	R:R:E364	R:R:H363	7.39	Yes	Yes	5	8	8
325	R:R:F390	R:R:H363	7.92	No	Yes	0	6	8
326	R:R:H363	R:R:Q394	11.13	Yes	Yes	5	8	9
327	R:R:E364	R:R:E387	7.61	Yes	No	0	8	8
328	R:R:E364	R:R:T391	5.64	Yes	No	0	8	6
329	R:R:F369	R:R:V365	6.55	Yes	No	0	4	6
330	R:R:F367	R:R:I366	6.28	Yes	No	0	7	6
331	R:R:F367	R:R:M371	6.22	Yes	No	0	7	7
332	R:R:F367	R:R:I382	3.77	Yes	No	0	7	4
333	R:R:F367	R:R:K383	3.72	Yes	No	0	7	7
334	R:R:M371	R:R:V370	6.09	No	No	0	7	5
335	R:R:L379	R:R:M371	5.65	No	No	0	3	7
336	R:R:E373	R:R:R380	5.82	Yes	No	0	4	5
337	R:R:A375	R:R:L379	3.15	No	No	0	4	3
338	R:R:R376	R:R:R380	3.2	No	No	0	5	5
339	R:R:E387	R:R:K383	6.75	No	No	0	8	7
340	R:R:F385	R:R:S389	5.28	No	No	0	6	5
341	R:R:F390	R:R:T386	6.49	No	No	0	6	4
342	R:R:F393	R:R:S392	5.28	No	No	2	7	9
343	R:R:I400	R:R:L396	4.28	No	No	0	6	7
344	R:R:F404	R:R:I400	3.77	No	No	0	8	6
345	R:R:L401	R:R:Y402	3.52	No	No	0	8	8
346	R:R:E408	R:R:N406	3.94	No	No	0	9	9
347	R:R:N406	R:R:V409	7.39	No	No	0	9	9
348	R:R:K415	R:R:L411	4.23	No	No	0	7	4
349	R:R:E412	R:R:K415	10.8	No	No	0	8	7
350	R:R:E418	R:R:W417	5.45	No	No	17	4	5
351	R:R:R421	R:R:W417	7	No	No	17	4	5
352	R:R:E418	R:R:R421	9.3	No	No	17	4	4
353	R:R:E423	R:R:W420	5.45	No	No	0	4	4
354	R:R:M233	R:R:S193	3.07	No	No	0	6	6
355	R:R:I323	R:R:V249	3.07	No	No	0	8	6
356	R:R:K336	R:R:V332	3.04	No	No	0	6	6
357	R:R:F369	R:R:G318	3.01	Yes	No	0	4	4
358	R:R:L396	R:R:S155	3	No	No	0	7	9
359	R:R:L181	R:R:S163	3	No	No	0	6	6
360	R:R:L32	R:R:V36	2.98	No	No	0	4	2
361	R:R:L245	R:R:V249	2.98	No	No	0	8	6
362	R:R:L245	R:R:V319	2.98	No	No	0	8	6
363	R:R:L356	R:R:V327	2.98	No	No	0	9	9
364	R:R:L349	R:R:V332	2.98	No	No	0	9	6
365	R:R:D114	R:R:S117	2.94	No	No	0	4	7
366	L:L:D15	R:R:V30	2.92	No	No	0	0	2
367	R:R:I330	R:R:K334	2.91	No	No	0	9	9
368	R:R:F61	R:R:P56	2.89	No	No	0	3	1
369	R:R:P119	R:R:R121	2.88	No	No	0	6	6
370	R:R:I146	R:R:L142	2.85	No	No	0	4	3
371	R:R:I330	R:R:L255	2.85	No	No	0	9	8
372	L:L:I23	L:L:N28	2.83	Yes	No	0	0	0
373	R:R:E262	R:R:T175	2.82	No	No	0	6	7
374	R:R:K346	R:R:L349	2.82	No	No	0	6	9
375	R:R:A200	R:R:F230	2.77	No	No	0	4	5
376	R:R:A238	R:R:F280	2.77	No	No	0	6	5
377	L:L:A18	R:R:Y205	2.67	No	Yes	0	0	3
378	R:R:L217	R:R:Q213	2.66	Yes	No	0	4	4
379	R:R:H363	R:R:I357	2.65	Yes	No	0	8	8
380	R:R:N115	R:R:Q112	2.64	No	No	0	4	3
381	R:R:F169	R:R:S416	2.64	Yes	No	0	7	5
382	R:R:F321	R:R:V325	2.62	No	No	0	6	5
383	R:R:F195	R:R:T149	2.59	No	No	0	7	7
384	R:R:A239	R:R:W274	2.59	No	Yes	0	8	9
385	R:R:F404	R:R:I161	2.51	No	No	0	8	4
386	R:R:T175	R:R:Y250	2.5	No	Yes	0	7	8
387	R:R:F66	R:R:L50	2.44	No	No	0	7	4
388	R:R:I323	R:R:Y252	2.42	No	No	0	8	8
389	R:R:I265	R:R:W264	2.35	No	No	0	5	5
390	R:R:L290	R:R:Y289	2.34	No	Yes	0	3	3
391	L:L:Y13	R:R:E138	2.24	No	No	0	0	2
392	R:R:F195	R:R:Y152	2.06	No	Yes	0	7	7
393	R:R:G275	R:R:P277	2.03	No	No	0	6	9
394	R:R:C296	R:R:G295	1.96	No	No	0	9	4
395	R:R:P54	R:R:P55	1.95	No	No	0	2	1
396	R:R:P55	R:R:P56	1.95	No	No	0	1	1
397	R:R:W203	R:R:Y220	1.93	No	No	0	3	3
398	R:R:C85	R:R:P96	1.88	Yes	No	0	9	3
399	R:R:A106	R:R:P77	1.87	No	Yes	0	1	4
400	R:R:A92	R:R:C85	1.81	No	Yes	0	5	9
401	R:R:A158	R:R:A399	1.79	No	No	0	7	8
402	R:R:G151	R:R:L154	1.71	Yes	No	0	8	5
403	R:R:A158	R:R:S157	1.71	No	No	0	7	3
404	R:R:C329	R:R:V325	1.71	No	No	0	7	5
405	R:R:A200	R:R:V229	1.7	No	No	0	4	7
406	L:L:A19	R:R:T35	1.68	No	Yes	0	0	5
407	R:R:D74	R:R:G75	1.68	Yes	No	0	3	7
408	R:R:M397	R:R:P358	1.68	No	No	0	5	9
409	R:R:G98	R:R:Q97	1.64	No	No	0	4	4
410	R:R:L118	R:R:P119	1.64	No	No	0	4	6
411	R:R:C341	R:R:I345	1.64	No	No	0	4	5
412	R:R:S79	R:R:V81	1.62	No	No	0	5	6
413	R:R:S94	R:R:V95	1.62	No	No	0	4	5
414	R:R:D53	R:R:P54	1.61	No	No	0	3	2
415	R:R:V327	R:R:V331	1.6	No	No	0	9	8
416	R:R:A368	R:R:L314	1.58	No	No	0	6	4
417	L:L:A24	L:L:N28	1.56	No	No	0	0	0
418	R:R:I196	R:R:V229	1.54	No	No	0	5	7
419	R:R:K202	R:R:S206	1.53	No	No	0	4	4
420	R:R:I382	R:R:T378	1.52	No	No	0	4	2
421	R:R:L118	R:R:S117	1.5	No	No	0	4	7
422	R:R:K342	R:R:T343	1.5	No	No	0	5	5
423	R:R:G377	R:R:R376	1.5	No	No	0	4	5
424	R:R:L278	R:R:V282	1.49	No	No	0	3	3
425	R:R:L401	R:R:V405	1.49	No	No	0	8	6
426	R:R:D122	R:R:S124	1.47	No	No	0	7	5
427	L:L:N28	L:L:T29	1.46	No	No	0	0	0
428	R:R:I286	R:R:L290	1.43	No	No	0	4	3
429	R:R:A153	R:R:F195	1.39	No	No	0	6	7
430	L:L:E16	L:L:K20	1.35	No	No	0	0	0
431	R:R:N407	R:R:Q410	1.32	No	No	0	6	7
432	R:R:A185	R:R:W274	1.3	No	Yes	0	3	9
433	R:R:I146	R:R:Y145	1.21	No	No	0	4	5
434	R:R:L224	R:R:Y289	1.17	No	Yes	0	3	3
435	R:R:E52	R:R:R48	1.16	No	No	0	2	4
436	R:R:H374	R:R:R376	1.13	No	No	0	3	5
437	R:R:R421	R:R:W420	1	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:H1	8.395	4	4	0
2	L:L:Q3	4.562	5	2	0
3	L:L:F6	5.41	4	2	0
4	L:L:F22	8.084	5	1	0
5	L:L:I23	4.25	4	0	0
6	R:R:T35	3.855	4	1	5
7	R:R:K38	7.27	4	1	4
8	R:R:W39	10.822	5	1	5
9	R:R:Y42	9.685	6	1	6
10	R:R:R43	7.625	4	1	4
11	R:R:E68	5.18	4	1	4
12	R:R:W72	7.615	4	0	9
13	R:R:D74	7.225	4	9	3
14	R:R:P77	5.16	4	0	4
15	R:R:C85	3.23	4	0	9
16	R:R:Y88	9.832	5	1	5
17	R:R:L89	6.174	5	1	5
18	R:R:Y101	14.3025	4	11	5
19	R:R:E107	5.335	4	0	5
20	R:R:W110	12.61	5	0	9
21	R:R:Y148	6.67833	6	2	7
22	R:R:G151	4.5325	4	2	8
23	R:R:Y152	6.21571	7	2	7
24	R:R:L159	4.2925	4	0	9
25	R:R:L166	5.4575	4	0	8
26	R:R:F169	8.055	4	0	7
27	R:R:R176	5.2025	4	7	9
28	R:R:N177	5.3625	4	7	9
29	R:R:H180	5.6275	4	7	9
30	R:R:F187	8.888	5	0	8
31	R:R:R190	10.25	5	0	8
32	R:R:K197	7.536	5	0	6
33	R:R:M204	6.525	4	3	3
34	R:R:Y205	5.43833	6	3	3
35	R:R:W214	11.1025	4	1	1
36	R:R:L217	4.068	5	0	4
37	R:R:Q234	6.982	5	4	7
38	R:R:Y241	8.815	4	5	8
39	R:R:Y242	5.982	5	6	6
40	R:R:W243	11.095	6	12	9
41	R:R:Y250	6.5225	4	14	8
42	R:R:Y269	5.7575	4	14	7
43	R:R:W274	8.512	5	12	9
44	R:R:W284	10.726	5	4	8
45	R:R:Y289	4.095	4	8	3
46	R:R:W297	10.716	5	8	8
47	R:R:R299	5.9175	4	3	4
48	R:R:W306	11.332	5	4	6
49	R:R:R310	8.97	4	4	6
50	R:R:H363	6.454	5	5	8
51	R:R:E364	7.514	5	5	8
52	R:R:F367	4.9975	4	0	7
53	R:R:F369	5.7875	4	0	4
54	R:R:E373	7.778	5	4	4
55	R:R:L388	5.446	5	2	7
56	R:R:Q394	7.9025	4	5	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:H1	R:R:V237	12.7552	15.22	Yes	No	0	0	6
2	R:R:M233	R:R:Q234	17.271	5.44	No	Yes	0	6	7
3	R:R:K197	R:R:M233	19.1386	7.2	Yes	No	0	6	6
4	L:L:Q3	R:R:K197	85.0178	4.07	Yes	Yes	0	0	6
5	L:L:Q3	R:R:L388	19.5005	3.99	Yes	Yes	2	0	7
6	L:L:S2	R:R:L388	15.4626	6.01	No	Yes	0	0	7
7	R:R:R190	R:R:V237	13.0115	14.38	Yes	No	0	8	6
8	R:R:R190	R:R:Y152	70.0048	11.32	Yes	Yes	0	8	7
9	L:L:Q3	R:R:Y152	66.8363	3.38	Yes	Yes	2	0	7
10	R:R:R190	R:R:Y241	20.1947	8.23	Yes	Yes	0	8	8
11	R:R:E364	R:R:Y241	14.087	10.1	Yes	Yes	5	8	8
12	R:R:E364	R:R:E387	15.0182	7.61	Yes	No	0	8	8
13	L:L:S2	R:R:E387	15.147	7.19	No	No	0	0	8
14	R:R:R190	R:R:T391	14.5494	6.47	Yes	No	0	8	6
15	R:R:E364	R:R:T391	14.0342	5.64	Yes	No	0	8	6
16	R:R:F230	R:R:K197	100	4.96	No	Yes	0	5	6
17	R:R:F230	R:R:T298	99.7579	7.78	No	No	0	5	5
18	R:R:R299	R:R:T298	99.2967	5.17	Yes	No	3	4	5
19	R:R:R299	R:R:Y205	99.4745	3.09	Yes	Yes	3	4	3
20	R:R:L217	R:R:W214	88.6333	3.42	Yes	Yes	0	4	1
21	R:R:L217	R:R:Q221	96.9088	3.99	Yes	No	0	4	4
22	R:R:Q221	R:R:Y205	94.4139	3.38	No	Yes	3	4	3
23	L:L:F22	R:R:W214	57.5639	11.02	Yes	Yes	1	0	1
24	L:L:F22	L:L:I23	26.7095	6.28	Yes	Yes	0	0	0
25	L:L:W25	R:R:W214	30.5658	23.43	No	Yes	1	0	1
26	L:L:F22	L:L:L26	30.6779	7.31	Yes	No	1	0	0
27	L:L:L26	L:L:W25	30.2953	6.83	No	No	1	0	0
28	L:L:I23	L:L:M27	14.6073	4.37	Yes	No	0	0	0
29	L:L:I23	R:R:W91	10.8798	3.52	Yes	No	0	0	4
30	L:L:L26	R:R:W39	60.2403	13.67	No	Yes	1	0	5
31	L:L:M27	R:R:L89	10.0014	4.24	No	Yes	1	0	5
32	R:R:L89	R:R:W91	10.4599	3.42	Yes	No	0	5	4
33	R:R:R43	R:R:W39	48.8801	14.99	Yes	Yes	1	4	5
34	R:R:Y42	R:R:Y88	13.9775	15.89	Yes	Yes	1	6	5
35	R:R:L89	R:R:P86	18.8964	8.21	Yes	No	0	5	8
36	R:R:C46	R:R:R43	44.4699	5.57	No	Yes	0	8	4
37	R:R:C46	R:R:F66	41.8591	6.98	No	No	0	8	7
38	R:R:F66	R:R:W72	39.0268	10.02	No	Yes	0	7	9
39	R:R:R64	R:R:W72	25.3726	13	No	Yes	0	4	9
40	R:R:R64	R:R:W110	24.3898	34.99	No	Yes	0	4	9
41	R:R:C104	R:R:W110	12.3842	6.53	No	Yes	0	9	9
42	R:R:C104	R:R:E107	10.344	4.56	No	Yes	0	9	5
43	R:R:C85	R:R:P86	19.5031	3.77	Yes	No	0	9	8
44	R:R:C85	R:R:P96	16.4853	1.88	Yes	No	0	9	3
45	R:R:P96	R:R:Q97	15.4742	7.9	No	No	0	3	4
46	R:R:G98	R:R:Q97	12.4255	1.64	No	No	0	4	4
47	R:R:E125	R:R:G98	11.4041	3.27	No	No	0	5	4
48	R:R:N240	R:R:R190	52.8871	10.85	No	Yes	0	9	8
49	R:R:F187	R:R:N240	23.4199	16.92	Yes	No	0	8	9
50	R:R:F187	R:R:L159	18.0412	4.87	Yes	Yes	0	8	9
51	R:R:F184	R:R:L159	13.4456	4.87	No	Yes	0	8	9
52	R:R:F184	R:R:L166	12.2967	4.87	No	Yes	0	8	8
53	R:R:N240	R:R:S186	35.5311	7.45	No	No	0	9	9
54	R:R:S186	R:R:W243	35.0262	7.41	No	Yes	0	9	9
55	R:R:I179	R:R:W243	12.5401	4.7	No	Yes	0	8	9
56	R:R:Q234	R:R:W284	14.5236	12.05	Yes	Yes	4	7	8
57	R:R:K288	R:R:W284	12.5414	18.57	No	Yes	0	8	8
58	R:R:G273	R:R:W243	14.2519	8.44	No	Yes	0	9	9
59	R:R:G273	R:R:I272	13.631	3.53	No	No	0	9	6
60	R:R:I272	R:R:V276	12.3817	4.61	No	No	0	6	3
61	R:R:V276	R:R:Y242	10.4471	7.57	No	Yes	6	3	6
62	R:R:E364	R:R:H363	36.0476	7.39	Yes	Yes	5	8	8
63	R:R:H363	R:R:I357	33.0131	2.65	Yes	No	0	8	8
64	R:R:I357	R:R:T362	28.9674	6.08	No	No	0	8	7
65	R:R:F324	R:R:T362	27.6137	9.08	No	No	0	9	7
66	R:R:F324	R:R:L356	23.5371	3.65	No	No	0	9	9
67	R:R:L356	R:R:V327	19.4374	2.98	No	No	0	9	9
68	R:R:V327	R:R:V331	16.6914	1.6	No	No	0	9	8
69	R:R:S352	R:R:V331	15.3145	3.23	No	No	0	9	8
70	R:R:R348	R:R:S352	13.935	6.59	No	No	0	8	9
71	R:R:L335	R:R:R348	11.1684	4.86	No	No	0	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:H1	R:R:Q234	6.18	4	Yes	Yes	0	7	0	1
L:L:H1	R:R:V237	15.22	4	Yes	No	0	6	0	1
L:L:H1	R:R:W306	7.41	4	Yes	Yes	0	6	0	1
L:L:S2	R:R:E387	7.19	0	No	No	0	8	0	1
L:L:S2	R:R:L388	6.01	0	No	Yes	0	7	0	1
L:L:Q3	R:R:Y148	5.64	2	Yes	Yes	0	7	0	1
L:L:Q3	R:R:Y152	3.38	2	Yes	Yes	0	7	0	1
L:L:Q3	R:R:V194	5.73	2	Yes	No	0	7	0	1
L:L:Q3	R:R:K197	4.07	2	Yes	Yes	0	6	0	1
L:L:Q3	R:R:L388	3.99	2	Yes	Yes	0	7	0	1
L:L:T5	R:R:E373	9.88	0	No	Yes	0	4	0	1
L:L:T5	R:R:L384	5.9	0	No	No	0	5	0	1
L:L:F6	R:R:L141	3.65	2	Yes	No	0	5	0	1
L:L:F6	R:R:L144	4.87	2	Yes	No	0	6	0	1
L:L:F6	R:R:Y148	8.25	2	Yes	Yes	0	7	0	1
L:L:F6	R:R:L388	4.87	2	Yes	Yes	0	7	0	1
L:L:T7	R:R:K197	9.01	0	No	Yes	0	6	0	1
L:L:S8	R:R:N300	7.45	0	No	No	0	6	0	1
L:L:D9	R:R:R380	8.34	0	No	No	0	5	0	1
L:L:Y10	R:R:L201	3.52	0	No	No	0	7	0	1
L:L:Y10	R:R:K202	7.17	0	No	No	0	4	0	1
L:L:S11	R:R:T298	6.4	3	No	No	0	5	0	1
L:L:S11	R:R:R299	9.22	3	No	Yes	0	4	0	1
L:L:K12	R:R:R299	6.19	0	No	Yes	0	4	0	1
L:L:L14	R:R:Y205	5.86	0	No	Yes	0	3	0	1
L:L:D15	R:R:Y205	8.05	0	No	Yes	0	3	0	1
L:L:E16	R:R:V30	11.41	0	No	No	0	2	0	1
L:L:E21	R:R:A209	4.53	0	No	No	0	1	0	1
L:L:E21	R:R:W214	6.54	0	No	Yes	0	1	0	1
L:L:F22	R:R:V36	11.8	1	Yes	No	0	2	0	1
L:L:F22	R:R:W214	11.02	1	Yes	Yes	0	1	0	1
L:L:I23	R:R:W91	3.52	0	Yes	No	0	4	0	1
L:L:W25	R:R:W214	23.43	1	No	Yes	0	1	0	1
L:L:L26	R:R:W39	13.67	1	No	Yes	0	5	0	1
L:L:M27	R:R:Y88	7.18	1	No	Yes	0	5	0	1
L:L:M27	R:R:L89	4.24	1	No	Yes	0	5	0	1
R:R:E34	R:R:T35	4.23	1	No	Yes	4	5	2	1
R:R:E34	R:R:K38	8.1	1	No	Yes	4	4	2	2
R:R:K38	R:R:T35	6.01	1	Yes	Yes	4	5	2	1
R:R:P90	R:R:T35	3.5	0	No	Yes	4	5	2	1
R:R:K38	R:R:Y88	9.55	1	Yes	Yes	4	5	2	1
R:R:R40	R:R:W39	13	0	No	Yes	2	5	2	1
R:R:R43	R:R:W39	14.99	1	Yes	Yes	4	5	2	1
R:R:E68	R:R:W39	7.63	1	Yes	Yes	4	5	2	1
R:R:W39	R:R:Y88	4.82	1	Yes	Yes	5	5	1	1
R:R:R43	R:R:Y42	4.12	1	Yes	Yes	4	6	2	2
R:R:P86	R:R:Y42	4.17	0	No	Yes	8	6	2	2
R:R:Y42	R:R:Y88	15.89	1	Yes	Yes	6	5	2	1
R:R:E68	R:R:R43	5.82	1	Yes	Yes	4	4	2	2
R:R:L89	R:R:P86	8.21	1	Yes	No	5	8	1	2
R:R:L89	R:R:Y88	11.72	1	Yes	Yes	5	5	1	1
R:R:L89	R:R:P90	3.28	1	Yes	No	5	4	1	2
R:R:L89	R:R:W91	3.42	1	Yes	No	5	4	1	1
R:R:E127	R:R:W91	14.17	0	No	No	2	4	2	1
R:R:F381	R:R:L144	7.31	0	No	No	4	6	2	1
R:R:L144	R:R:L388	4.15	2	No	Yes	6	7	1	1
R:R:Y145	R:R:Y148	4.96	2	No	Yes	5	7	2	1
R:R:D198	R:R:Y145	10.34	2	No	No	7	5	2	2
R:R:Y148	R:R:Y152	4.96	2	Yes	Yes	7	7	1	1
R:R:D198	R:R:Y148	8.05	2	No	Yes	7	7	2	1
R:R:L388	R:R:Y148	8.21	2	Yes	Yes	7	7	1	1
R:R:R190	R:R:Y152	11.32	0	Yes	Yes	8	7	2	1
R:R:A191	R:R:Y152	5.34	0	No	Yes	7	7	2	1
R:R:V194	R:R:Y152	10.09	2	No	Yes	7	7	1	1
R:R:S392	R:R:Y152	6.36	2	No	Yes	9	7	2	1
R:R:R190	R:R:V237	14.38	0	Yes	No	8	6	2	1
R:R:D198	R:R:K197	12.44	2	No	Yes	7	6	2	1
R:R:F230	R:R:K197	4.96	0	No	Yes	5	6	2	1
R:R:K197	R:R:M233	7.2	0	Yes	No	6	6	1	2
R:R:M204	R:R:Y205	9.58	3	Yes	Yes	3	3	2	1
R:R:M204	R:R:Q221	6.8	3	Yes	No	3	4	2	2
R:R:Q221	R:R:Y205	3.38	3	No	Yes	4	3	2	1
R:R:R299	R:R:Y205	3.09	3	Yes	Yes	4	3	1	1
R:R:L217	R:R:W214	3.42	0	Yes	Yes	4	1	2	1
R:R:L217	R:R:Q221	3.99	0	Yes	No	4	4	2	2
R:R:F230	R:R:T298	7.78	0	No	No	5	5	2	1
R:R:M233	R:R:Q234	5.44	0	No	Yes	6	7	2	1
R:R:Q234	R:R:W284	12.05	4	Yes	Yes	7	8	1	2
R:R:Q234	R:R:W306	4.38	4	Yes	Yes	7	6	1	1
R:R:I309	R:R:Q234	6.86	4	No	Yes	7	7	2	1
R:R:I309	R:R:W284	12.92	4	No	Yes	7	8	2	2
R:R:R299	R:R:T298	5.17	3	Yes	No	4	5	1	1
R:R:N300	R:R:W306	20.34	0	No	Yes	6	6	1	1
R:R:E373	R:R:M303	10.83	4	Yes	No	4	5	1	2
R:R:R310	R:R:W306	17.99	4	Yes	Yes	6	6	2	1
R:R:E373	R:R:W306	6.54	4	Yes	Yes	4	6	1	1
R:R:E373	R:R:R310	5.82	4	Yes	Yes	4	6	1	2
R:R:E364	R:R:E387	7.61	5	Yes	No	8	8	2	1
R:R:E373	R:R:R380	5.82	4	Yes	No	4	5	1	1
R:R:R376	R:R:R380	3.2	0	No	No	5	5	2	1
R:R:E387	R:R:K383	6.75	0	No	No	8	7	1	2
R:R:L32	R:R:V36	2.98	0	No	No	4	2	2	1
L:L:D15	R:R:V30	2.92	0	No	No	0	2	0	1
L:L:A18	R:R:Y205	2.67	0	No	Yes	0	3	0	1
L:L:Y13	R:R:E138	2.24	0	No	No	0	2	0	1
R:R:F195	R:R:Y152	2.06	0	No	Yes	7	7	2	1
L:L:A19	R:R:T35	1.68	0	No	Yes	0	5	0	1
R:R:K202	R:R:S206	1.53	0	No	No	4	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8JIS_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.09
Number of Linked Nodes	389
Number of Links	437
Number of Hubs	56
Number of Links mediated by Hubs	212
Number of Communities	17
Number of Nodes involved in Communities	92
Number of Links involved in Communities	114

Path Summary
Number Of Nodes in MetaPath	72
Number Of Links MetaPath	71
Number of Shortest Paths	129293
Length Of Smallest Path	3
Average Path Length	18.9923
Length of Longest Path	45
Minimum Path Strength	1.315
Average Path Strength	7.05497
Maximum Path Strength	23.995
Minimum Path Correlation	0.7
Average Path Correlation	0.962773
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	59.7034
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.8443
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • D2 dopamine receptor binding • adenylate cyclase inhibitor activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • negative regulation of peptide hormone secretion • negative regulation of establishment of protein localization • negative regulation of protein secretion • negative regulation of signaling • negative regulation of cell communication • negative regulation of peptide secretion • negative regulation of cellular process • negative regulation of protein localization • negative regulation of insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • protein binding • binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to stimulus • response to stimulus • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • cellular process • cell population proliferation • regulation of biological process • regulation of cellular process • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • dendrite • dendritic tree • neuron projection • non-motile cilium • 9+0 non-motile cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • plasma membrane region • cell projection membrane • synapse • cell junction • cell body • G-protein beta-subunit binding • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • glucagon receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • amide binding • peptide hormone binding • hormone binding • glucagon-like peptide 1 receptor activity • heart process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • blood circulation • regulation of blood pressure • positive regulation of blood pressure • response to psychosocial stress • cell surface receptor signaling pathway • behavior • learning or memory • cognition • transport • secretion • regulation of hormone levels • cell-cell signaling • export from cell • hormone secretion • establishment of localization • localization • secretion by cell • signal release • hormone transport • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • establishment of protein localization • cellular localization • nitrogen compound transport • protein targeting • protein transmembrane transport • establishment of localization in cell • post-translational protein targeting to membrane, translocation • intracellular protein localization • establishment of protein localization to endoplasmic reticulum • establishment of protein localization to membrane • intracellular protein transmembrane transport • intracellular transport • post-translational protein targeting to endoplasmic reticulum membrane • localization within membrane • protein targeting to membrane • transmembrane transport • establishment of protein localization to organelle • protein transport • macromolecule localization • intracellular protein transport • protein targeting to ER • negative regulation of blood pressure
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • FnI-like domain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • FnI-like domain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P43220
Sequence	>8JIS_nogp_Chain_R V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E P E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F R H L H C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S T A A Q Q H Q W D G L L S Y Q D S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S V L S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E D E G C W T R N S N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L M C K T D I K C R L A K S T L T L I P L L G T H E V I F A F V M D E H A R G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E V Q L E F R K S W E R W R L E Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6ORV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2	Gs/β1/γ2	3	2020-01-08	doi.org/10.1038/s41586-019-1902-z
	6ORV (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2		3	2020-01-08	doi.org/10.1038/s41586-019-1902-z
	7E14	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738	Gs/β1/γ2	2.9	2021-07-07	doi.org/10.1038/s41467-021-24058-z
	7E14 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738		2.9	2021-07-07	doi.org/10.1038/s41467-021-24058-z
	7DUQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738	Gs/β1/γ2	2.5	2021-07-14	doi.org/10.1038/s41467-021-24058-z
	7DUQ (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738		2.5	2021-07-14	doi.org/10.1038/s41467-021-24058-z
	7DUR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	3.3	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7DUR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		3.3	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7EVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/β1/γ2	2.5	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	7EVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738		2.5	2021-08-11	doi.org/10.1038/s41467-021-24058-z
	5VEW	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.7	2017-05-24	doi.org/10.1038/nature22378
	6LN2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	3.2	2020-03-18	doi.org/10.1038/s41467-020-14934-5
	6KJV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.8	2019-11-13	doi.org/10.1107/S2052252519013496
	6KK1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.8	2019-11-13	doi.org/10.1107/S2052252519013496
	6KK7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	3.1	2019-11-13	doi.org/10.1107/S2052252519013496
	5VEX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	NNC0640	-	3	2017-05-17	doi.org/10.1038/nature22378
	9IVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839	chim(NtGi1-Gs)/β2/γ2	3.22	2024-11-13	doi.org/10.1016/j.apsb.2024.09.002
	9IVM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	LSN3318839		3.22	2024-11-13	doi.org/10.1016/j.apsb.2024.09.002
	6VCB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440	Gs/β1/γ2	3.3	2020-07-22	doi.org/10.1038/s41589-020-0589-7
	6VCB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440		3.3	2020-07-22	doi.org/10.1038/s41589-020-0589-7
	9IVG	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	chim(NtGi1-Gs)/β1/γ2	3	2024-11-27	doi.org/10.1016/j.apsb.2024.09.002
	9IVG (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-		3	2024-11-27	doi.org/10.1016/j.apsb.2024.09.002
	7RTB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-	Gs/β1/γ2	2.14	2021-10-06	doi.org/10.1016/j.bbrc.2021.09.016
	7RTB (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-		2.14	2021-10-06	doi.org/10.1016/j.bbrc.2021.09.016
	7KI0	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-	Gs/β1/γ2	2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI0 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-		2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-	Gs/β1/γ2	2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	7KI1 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-		2.5	2021-08-04	doi.org/10.1016/j.celrep.2021.109374
	6X18	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-	Gs/β1/γ2	2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X18 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-		2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X19	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-	Gs/β1/γ2	2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X19 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-		2.1	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X1A	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.5	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	6X1A (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.5	2020-09-09	doi.org/10.1016/j.molcel.2020.09.020
	7LCI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/β1/γ2	2.9	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-		2.9	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCJ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	2.82	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7LCK	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	3.24	2021-01-20	doi.org/10.1016/j.str.2021.04.008
	7S15	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 134611223	-	-	3.8	2022-06-08	doi.org/10.1021/acs.jmedchem.1c01856
	9J1P	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-	chim(NtGi1-Gs)/β1/γ2	2.99	2025-02-26	doi.org/10.1021/jacs.4c12808
	9J1P (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	g1:Ox	-		2.99	2025-02-26	doi.org/10.1021/jacs.4c12808
	5VAI	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-	Gs/β1/γ2	4.1	2017-05-24	doi.org/10.1038/nature22394
	5VAI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-		4.1	2017-05-24	doi.org/10.1038/nature22394
	5NX2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	-	3.7	2017-06-14	doi.org/10.1038/nature22800
	6B3J	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-	Gs/β1/γ2	3.3	2018-02-21	doi.org/10.1038/nature25773
	6B3J (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-		3.3	2018-02-21	doi.org/10.1038/nature25773
	8WG7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.54	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	8WG7 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.54	2024-03-06	doi.org/10.1038/s41421-024-00649-0
	7C2E	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-	Gs/β1/γ2	4.2	2020-08-26	doi.org/10.1038/s41422-020-0384-8
	7C2E (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-		4.2	2020-08-26	doi.org/10.1038/s41422-020-0384-8
	7LLL	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/β1/γ2	3.7	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLL (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-		3.7	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLY	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-	Gs/β1/γ2	3.3	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7LLY (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-		3.3	2022-01-12	doi.org/10.1038/s41467-021-27760-0
	7FIM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	Gs/β1/γ2	3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7FIM (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		3.4	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-	Gs/β1/γ2	3	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBI (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-		3	2022-03-02	doi.org/10.1038/s41467-022-28683-0
	7VBH	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-	Gs/β1/γ2	3	2022-04-06	doi.org/10.1038/s41467-022-28683-0
	7VBH (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-		3	2022-04-06	doi.org/10.1038/s41467-022-28683-0
	7S1M	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-	Gs/β1/γ2	2.41	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S1M (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-		2.41	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S3I	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	2.51	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	7S3I (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		2.51	2022-01-05	doi.org/10.1038/s41589-021-00945-w
	6XOX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-	chim(NtGi1-Gs)/β1/γ2	3.1	2020-11-18	doi.org/10.1073/pnas.2014879117
	6XOX (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-		3.1	2020-11-18	doi.org/10.1073/pnas.2014879117
	7RG9	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.2	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RG9 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.2	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RGP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	chim(NtGi1-Gs)/β1/γ2	2.9	2022-04-13	doi.org/10.1073/pnas.2116506119
	7RGP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-		2.9	2022-04-13	doi.org/10.1073/pnas.2116506119
	7X8R	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-	Gs/β1/γ2	2.61	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8R (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-		2.61	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8S	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-	Gs/β1/γ2	3.09	2022-06-29	doi.org/10.1073/pnas.2200155119
	7X8S (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-		3.09	2022-06-29	doi.org/10.1073/pnas.2200155119
	8JIP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-	chim(NtGi1-Gs)/β1/γ2	2.85	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIP (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-		2.85	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-	chim(NtGi1-Gs)/β1/γ2	2.57	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIR (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-		2.57	2023-09-06	doi.org/10.1073/pnas.2303696120
	8JIS	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-	chim(NtGi1-Gs)/β1/γ2	2.46	2023-11-08	doi.org/10.1073/pnas.2303696120
	8JIS (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-		2.46	2023-11-08	doi.org/10.1073/pnas.2303696120
	8YW3	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-	Gs/β1/γ2	2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	8YW3 (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-		2.68	2024-09-18	doi.org/10.1038/s41421-024-00700-0
	9EBN	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	3.44	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBN (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.44	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBO	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (ACPC18)	-	Gs/β1/γ2	3.13	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBO (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (ACPC18)	-		3.13	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/β1/γ2	3.16	2025-03-26	doi.org/10.1073/pnas.2407574122
	9EBQ (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-		3.16	2025-03-26	doi.org/10.1073/pnas.2407574122
	8YWF	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-	chim(NtGi1-Gs)/β1/γ2	2.74	2025-04-16	To be published
	8YWF (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Retatrutide	-		2.74	2025-04-16	To be published
	9BYO	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-3	-	Gs/β1/γ2	2.31	2025-06-11	To be published
	9BYO (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-3	-		2.31	2025-06-11	To be published
	9C0K	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/β1/γ2	2.72	2025-06-11	To be published
	9C0K (No Gprot)	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-		2.72	2025-06-11	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8JIS_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.