Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:H41 4.645456
2A:A:L45 4.9925458
3A:A:S51 3.4409
4A:A:K53 4.7075409
5A:A:F212 4.138559
6A:A:V214 4.31556
7A:A:F219 5.28167658
8A:A:H220 12.2125417
9A:A:F222 13.6925417
10A:A:R228 5.93419
11A:A:K233 5.40429719
12A:A:F238 6.306519
13A:A:I244 4.0475408
14A:A:F246 3.7175409
15A:A:F273 4.6865149
16A:A:W277 5.936146
17A:A:W281 9.456515
18A:A:I288 3.9225409
19A:A:F290 5.61254119
20A:A:L296 5.1265126
21A:A:F312 5.275138
22A:A:E314 5.634136
23A:A:F315 8.1525406
24A:A:P321 4.316565
25A:A:E330 6.214563
26A:A:Y339 4.19463
27A:A:F340 8.5185137
28A:A:R342 6.2425404
29A:A:S349 3.1785147
30A:A:Y358 6.3625404
31A:A:C359 3.35254145
32A:A:Y360 6.685188
33A:A:F363 6.97465
34A:A:T364 6.76754119
35A:A:D368 7.83254119
36A:A:N371 4.2285119
37A:A:R373 3.8775455
38A:A:R374 7.0345114
39A:A:F376 4.8375458
40B:B:D27 7.9175408
41B:B:I37 5.2165152
42B:B:V40 3.4775403
43B:B:H54 6.495209
44B:B:L55 6.035406
45B:B:K57 7.582519
46B:B:M61 3.5475436
47B:B:W63 6.64333637
48B:B:D76 6.1485209
49B:B:L79 2.94254167
50B:B:W82 9.98509
51B:B:Y85 6.505434
52B:B:K89 6.452589
53B:B:I93 5.8975407
54B:B:L95 3.8854168
55B:B:W99 7.34333619
56B:B:Y105 4.73167606
57B:B:C114 2.934168
58B:B:L117 3.3375419
59B:B:H142 5.754519
60B:B:Y145 4.25818
61B:B:F151 3.85509
62B:B:L152 3.4725423
63B:B:I157 4.226517
64B:B:T159 4.93519
65B:B:S161 6.72419
66B:B:D163 7.075419
67B:B:C166 3.516528
68B:B:W169 8.104518
69B:B:F180 7.7125427
70B:B:H183 6.12167629
71B:B:D186 5.365619
72B:B:V187 4.102529
73B:B:F199 4.585629
74B:B:V200 6.53446
75B:B:S201 2.9825429
76B:B:C204 6.69417
77B:B:K209 9.1025426
78B:B:L210 4.205405
79B:B:W211 6.818528
80B:B:Q220 3.752547
81B:B:F222 6.145448
82B:B:H225 8.99667649
83B:B:D228 9.225419
84B:B:I229 5.0525447
85B:B:I232 5.095448
86B:B:F235 5.64816
87B:B:N237 7.594515
88B:B:F241 5.12571746
89B:B:T243 4.152548
90B:B:D247 8.9125449
91B:B:T249 5.132546
92B:B:R251 14.19448
93B:B:F253 6.6925446
94B:B:R256 9.3725409
95B:B:D258 9.3775447
96B:B:M262 6.95414
97B:B:Y264 6.374515
98B:B:R283 8.20754159
99B:B:Y289 6.37333617
100B:B:D290 5.61167616
101B:B:L300 4.545156
102B:B:H311 7.216599
103B:B:R314 13.144518
104B:B:W332 9.635619
105B:B:D333 8.22499
106B:B:K337 4.84496
107B:B:W339 8.5875499
108G:G:Q18 5.0725429
109G:G:L19 3.175409
110G:G:Y40 6.91416
111G:G:D48 5.232509
112G:G:P49 3.4325407
113G:G:F61 5.5125838
114R:R:Y152 9.47407
115R:R:L159 3.588509
116R:R:L166 3.8175408
117R:R:R176 5.5854199
118R:R:F184 3.5275408
119R:R:F187 6.55678
120R:R:R190 6.775478
121R:R:Y220 5.0675403
122R:R:F230 5.954175
123R:R:Y235 5.7025409
124R:R:W243 10.76336259
125R:R:L245 3.114508
126R:R:F266 5.2025406
127R:R:Y269 4.125407
128R:R:W274 6.625259
129R:R:F280 4.47405
130R:R:W284 5.5956178
131R:R:K288 9.8525408
132R:R:Y305 8.074284
133R:R:F324 5.223336109
134R:R:K334 5.195409
135R:R:L335 3.0825408
136R:R:T353 3.7054109
137R:R:I357 4.4254108
138R:R:H363 9.04667678
139R:R:F367 4.2525407
140R:R:Q394 4.8375479
141R:R:L396 4.3975407
142R:R:C403 3.21409
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:V246 R:R:Y269 26.25322.52NoYes087
2R:R:V246 R:R:W243 26.496.13NoYes089
3R:R:I179 R:R:W243 91.33043.52NoYes089
4R:R:F266 R:R:I179 95.69972.51YesNo068
5R:R:F266 R:R:Y178 96.35287.22YesNo066
6R:R:H173 R:R:Y178 96.57049.8NoNo076
7R:R:H173 R:R:R170 96.78792.26NoNo078
8B:B:R52 R:R:R170 97.00422.13NoNo078
9B:B:F335 B:B:R52 97.4399.62NoNo047
10B:B:D333 B:B:F335 97.87358.36YesNo094
11B:B:D333 B:B:H311 98.29410.08YesYes999
12B:B:H311 B:B:T329 49.79746.85YesNo998
13B:B:T329 B:B:W339 49.89889.7NoYes989
14B:B:L308 B:B:W339 1006.83NoYes079
15B:B:L308 B:B:M45 54.62077.07NoNo074
16B:B:M45 G:G:L50 10.11632.83NoNo049
17B:B:V327 G:G:L50 10.04685.96NoNo069
18B:B:S84 B:B:W63 13.39244.94NoYes357
19B:B:S84 B:B:Y85 12.28922.54NoYes354
20B:B:R68 B:B:Y85 12.11759.26NoYes054
21B:B:H311 B:B:K337 49.81135.24YesYes996
22B:B:K337 B:B:W339 49.89878.12YesYes969
23B:B:Q75 B:B:W99 49.07066.57NoYes199
24B:B:K57 B:B:Q75 49.19638.14YesNo199
25B:B:K57 B:B:W332 96.53348.12YesYes199
26A:A:W281 B:B:W332 48.63423.75YesYes159
27A:A:W281 B:B:D290 48.68017.82YesYes156
28B:B:C271 B:B:D290 97.68034.67NoYes156
29B:B:C271 B:B:Y289 97.61114.03NoYes157
30B:B:W297 B:B:Y289 92.61915.79NoYes187
31B:B:W297 B:B:Y264 93.734714.47NoYes185
32B:B:L285 B:B:Y264 99.26133.52NoYes165
33B:B:F278 B:B:L285 99.22398.53NoNo176
34B:B:F235 B:B:F278 99.30195.36YesNo167
35B:B:F235 G:G:Y40 53.83484.13YesYes166
36G:G:H44 G:G:Y40 54.705513.07NoYes066
37B:B:S281 G:G:H44 54.67112.79NoNo096
38B:B:S281 G:G:D48 54.65425.89NoYes099
39B:B:R314 B:B:W332 48.634225.99YesYes189
40B:B:D290 B:B:R314 48.680510.72YesYes168
41A:A:H387 R:R:L254 23.179716.71NoNo088
42R:R:L254 R:R:Y250 23.41543.52NoNo088
43R:R:Y250 R:R:Y269 23.88752.98NoYes087
44A:A:C237 A:A:F238 34.75232.79NoYes089
45A:A:C237 B:B:Y59 47.00255.38NoNo088
46B:B:K57 B:B:Y59 47.129211.94YesNo198
47A:A:F238 B:B:W99 34.86594.01YesYes199
48A:A:F238 A:A:L44 35.453317.05YesNo099
49A:A:I244 A:A:L44 34.34465.71YesNo089
50A:A:I244 A:A:V241 34.34073.07YesNo089
51A:A:F238 A:A:V241 34.61585.24YesNo099
52A:A:I244 A:A:L46 67.58392.85YesNo088
53A:A:F246 A:A:L46 67.02923.65YesNo098
54A:A:K300 A:A:L296 13.45122.82NoYes1296
55A:A:K300 A:A:S306 16.81377.65NoNo097
56A:A:I308 A:A:S306 18.49473.1NoNo077
57A:A:F312 A:A:F340 11.76777.5YesYes1387
58A:A:F340 A:A:Y318 23.52716.19YesNo076
59A:A:P321 A:A:Y318 24.08596.95YesNo056
60A:A:P321 A:A:Y339 34.72174.17YesYes653
61A:A:R342 A:A:Y339 36.38196.17YesYes043
62A:A:F363 A:A:R342 49.18629.62YesYes054
63A:A:F363 A:A:L291 56.43583.65YesNo658
64A:A:L291 A:A:V248 64.25492.98NoNo087
65A:A:F246 A:A:V248 65.36482.62YesNo097
66A:A:F315 A:A:I308 13.44836.28YesNo067
67A:A:D381 R:R:K334 10.29896.91NoYes089
68A:A:L394 R:R:K334 11.0132.82NoYes089
69A:A:L388 A:A:L394 13.02045.54NoNo088
70A:A:L388 R:R:L255 13.72626.92NoNo088
71A:A:H387 R:R:L255 13.9623.86NoNo088
72B:B:M101 B:B:Y145 11.99693.59NoYes198
73A:A:C237 B:B:M101 12.14023.24NoNo089
74B:B:L117 B:B:Y145 12.74573.52YesYes198
75B:B:L117 B:B:W99 12.17514.56YesYes199
76A:A:L346 A:A:S349 11.23284.5NoYes047
77A:A:L346 A:A:R342 11.79374.86NoYes044
78A:A:E330 A:A:K338 12.3028.1YesNo635
79B:B:G244 B:B:I273 10.26123.53NoNo056
80B:B:G244 B:B:T243 10.15263.64NoYes058
81B:B:D66 B:B:R68 11.84993.57NoNo085
82B:B:D66 B:B:L69 11.74044.07NoNo085
83B:B:L300 B:B:R283 45.27316.07YesYes1569
84B:B:D298 B:B:R283 45.275513.1NoYes099
85B:B:I43 B:B:M45 45.31782.92NoNo034
86B:B:I43 B:B:V40 45.33113.07NoYes033
87B:B:G162 B:B:Y145 15.11494.35NoYes198
88B:B:G162 B:B:S161 14.86163.71NoYes199
89B:B:H142 B:B:S161 12.863913.95YesYes199
90B:B:H142 B:B:T159 10.87074.11YesYes199
91B:B:L300 G:G:C41 45.54756.35YesNo067
92B:B:S279 G:G:D48 45.61368.83NoYes099
93B:B:L284 B:B:S279 45.58363NoNo059
94B:B:L308 B:B:V296 45.51682.98NoNo075
95B:B:L284 B:B:V296 45.55415.96NoNo055
96R:R:S186 R:R:W243 50.23077.41NoYes099
97R:R:L183 R:R:S186 26.52564.5NoNo099
98R:R:F187 R:R:L183 16.67976.09YesNo789
99R:R:F187 R:R:Q394 19.01343.51YesYes789
100R:R:H363 R:R:Q394 26.98269.89YesYes789
101R:R:N240 R:R:S186 23.4757.45NoNo099
102R:R:F187 R:R:N240 16.678418.12YesNo789
103R:R:F187 R:R:L159 14.29223.65YesYes089
104R:R:W243 R:R:W274 15.623118.74YesYes2599
105R:R:W274 R:R:Y235 14.90544.82YesYes099
106R:R:V281 R:R:Y235 11.28443.79NoYes069
107R:R:F390 R:R:H363 14.984822.63NoYes068
108R:R:F390 R:R:I357 14.28212.51NoYes068
109R:R:F324 R:R:I357 10.76512.51YesYes1098
110B:B:F235 G:G:C41 45.56432.79YesNo067
111B:B:D298 B:B:V40 45.41127.3NoYes093
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 9EBN
Class B1
SubFamily Peptide
Type Glucagon
SubType GLP-1
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 3.44
Date 2025-03-26
D.O.I. doi.org/10.1073/pnas.2407574122
Net Summary
Imin 2.44
Number of Linked Nodes 814
Number of Links 968
Number of Hubs 142
Number of Links mediated by Hubs 533
Number of Communities 28
Number of Nodes involved in Communities 223
Number of Links involved in Communities 310
Path Summary
Number Of Nodes in MetaPath 112
Number Of Links MetaPath 111
Number of Shortest Paths 3864103
Length Of Smallest Path 3
Average Path Length 45.1436
Length of Longest Path 77
Minimum Path Strength 1.34
Average Path Strength 6.26775
Maximum Path Strength 20.62
Minimum Path Correlation 0.7
Average Path Correlation 0.988599
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.96078
Average % Of Corr. Nodes 28.5671
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 45.1553
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• positive regulation of cytosolic calcium ion concentration   • biological regulation   • regulation of biological quality   • heart process   • multicellular organismal process   • system process   • regulation of biological process   • regulation of heart contraction   • regulation of system process   • circulatory system process   • regulation of blood circulation   • regulation of multicellular organismal process   • heart contraction   • blood circulation   • regulation of blood pressure   • positive regulation of blood pressure   • cellular response to stimulus   • regulation of cellular process   • response to stimulus   • signaling   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • response to stress   • response to psychosocial stress   • cell surface receptor signaling pathway   • behavior   • learning or memory   • nervous system process   • cognition   • transport   • secretion   • regulation of hormone levels   • cell-cell signaling   • export from cell   • hormone secretion   • establishment of localization   • localization   • secretion by cell   • signal release   • hormone transport   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • establishment of protein localization   • cellular localization   • nitrogen compound transport   • protein targeting   • protein transmembrane transport   • establishment of localization in cell   • post-translational protein targeting to membrane, translocation   • intracellular protein localization   • establishment of protein localization to endoplasmic reticulum   • establishment of protein localization to membrane   • intracellular protein transmembrane transport   • intracellular transport   • post-translational protein targeting to endoplasmic reticulum membrane   • localization within membrane   • protein targeting to membrane   • transmembrane transport   • establishment of protein localization to organelle   • protein transport   • macromolecule localization   • intracellular protein transport   • protein targeting to ER   • negative regulation of blood pressure   • cellular anatomical structure   • membrane   • cell periphery   • plasma membrane   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to oxygen-containing compound   • response to nitrogen compound   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • synapse   • cell junction   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of chemical stimulus   • sensory perception   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • molecular function regulator activity   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • cation binding   • metal ion binding   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • sensory perception of smell   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to glucagon   • cellular response to glucagon stimulus   • skeletal system development   • bone development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • coagulation   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • developmental growth   • growth   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of metabolic process   • positive regulation of cellular process   • regulation of localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • amide transport   • regulation of peptide hormone secretion   • regulation of signaling   • regulation of transport   • regulation of peptide transport   • regulation of establishment of protein localization   • establishment of protein localization to extracellular region   • regulation of protein transport   • protein secretion   • regulation of protein secretion   • regulation of secretion   • peptide transport   • regulation of insulin secretion   • peptide hormone secretion   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • endomembrane system   • trans-Golgi network
Gene OntologyCellular Component
SCOP2Domain Identifier• G protein-coupled receptor-like   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• G protein-coupled receptor-like   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>9EBN_Chain_A
RNEEKAQRE ANKKIEKQL QKDKQVYRA THRLLLLGA GESGKTIVK 
QMRILHSGI FETKFQVDK VNFHMFDVG QRDERRKWI QCFNDVTAI 
IFVVASSSN RLQALLFSI WNNWLRSVI LFLNKQDLL AEKVLAGKS 
KIEDYFPEF ARYTTPEDA TPEPGEDPR VTRAKYFIR DEFLRISTA 
SGDGRHYCY PHFTCAVDT ENIRRVFND CRDIIQRMH LRQYELLNA 
AKDKDT


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9EBN_Chain_B
LDQLRQEAE QLKNQIRDA RKACADATL SQITNNIDP VGRIQMRTR 
RTLRGHLAK IYAMHWGTD SRLLVSASQ DGKLIIWDS YTTNKVHAI 
PLRSSWVMT CAYAPSGNY VACGGLDNI CSIYNLKTR EGNVRVSRE 
LAGHTGYLS CCRFLDDNQ IVTSSGDTT CALWDIETG QQTTTFTGH 
TGDVMSLSL APDTRLFVS GACDASAKL WDVREGMCR QTFTGHESD 
INAICFFPN GNAFATGSD DATCRLFDL RADQELMTY SHDNIICGI 
TSVSFSKSG RLLLAGYDD FNCNVWDAL KADRAGVLA GHDNRVSCL 
GVTDDGMAV ATGSWDSFL KIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>9EBN_Chain_G
IAQARKLVE QLKMEANID RIKVSKAAA DLMAYCEAH AKEDPLLTP 
VPASENPF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP43220
Sequence
>9EBN_Chain_R
EEQLLFLYI IYTVGYALS FSALVIASA ILLGFRHLH CTRNYIHLN 
LFASFILRA LSVFIKDAA LKWMYSYQD SLSCRLVFL LMQYCVAAN 
YYWLLVEGV YLYTLLAFS VSEQWIFRL YVSIGWGVP LLFVVPWGI 
VKYLYEDEG CWTRNSNMN YWLIIRLPI LFAIGVNFL IFVRVICIV 
VSKLKANIK CRLAKSTLT LIPLLGTHE VIFATLRFI KLFTELSFT 
SFQGLMVAI LYCFVNNEV QLEFRKSWE RWF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6ORVB1PeptideGlucagonGLP-1Homo sapiens-TT-OAD2Gs/β1/γ232020-01-08doi.org/10.1038/s41586-019-1902-z
6ORV (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-TT-OAD232020-01-08doi.org/10.1038/s41586-019-1902-z
7E14B1PeptideGlucagonGLP-1Homo sapiensOrforglipronPubChem 156022738Gs/β1/γ22.92021-07-07doi.org/10.1038/s41467-021-24058-z
7E14 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOrforglipronPubChem 1560227382.92021-07-07doi.org/10.1038/s41467-021-24058-z
7DUQB1PeptideGlucagonGLP-1Homo sapiensGLP-1PubChem 156022738Gs/β1/γ22.52021-07-14doi.org/10.1038/s41467-021-24058-z
7DUQ (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1PubChem 1560227382.52021-07-14doi.org/10.1038/s41467-021-24058-z
7DURB1PeptideGlucagonGLP-1Homo sapiens-PubChem 156022738Gs/β1/γ23.32021-08-11doi.org/10.1038/s41467-021-24058-z
7DUR (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-PubChem 1560227383.32021-08-11doi.org/10.1038/s41467-021-24058-z
7EVMB1PeptideGlucagonGLP-1Homo sapiens-PubChem 156022738Gs/β1/γ22.52021-08-11doi.org/10.1038/s41467-021-24058-z
7EVM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-PubChem 1560227382.52021-08-11doi.org/10.1038/s41467-021-24058-z
5VEWB1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-2.72017-05-24doi.org/10.1038/nature22378
6LN2B1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-3.22020-03-18doi.org/10.1038/s41467-020-14934-5
6KJVB1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-2.82019-11-13doi.org/10.1107/S2052252519013496
6KK1B1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-2.82019-11-13doi.org/10.1107/S2052252519013496
6KK7B1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-3.12019-11-13doi.org/10.1107/S2052252519013496
5VEXB1PeptideGlucagonGLP-1Homo sapiens-NNC0640-32017-05-17doi.org/10.1038/nature22378
9IVMB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)LSN3318839chim(NtGi1-Gs)/β2/γ23.222024-11-13doi.org/10.1016/j.apsb.2024.09.002
9IVM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)LSN33188393.222024-11-13doi.org/10.1016/j.apsb.2024.09.002
6VCBB1PeptideGlucagonGLP-1Homo sapiensGLP-1LSN3160440Gs/β1/γ23.32020-07-22doi.org/10.1038/s41589-020-0589-7
6VCB (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1LSN31604403.32020-07-22doi.org/10.1038/s41589-020-0589-7
9IVGB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ232024-11-27doi.org/10.1016/j.apsb.2024.09.002
9IVG (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)-32024-11-27doi.org/10.1016/j.apsb.2024.09.002
7RTBB1PeptideGlucagonGLP-1Homo sapiensPeptide-19-Gs/β1/γ22.142021-10-06doi.org/10.1016/j.bbrc.2021.09.016
7RTB (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-19-2.142021-10-06doi.org/10.1016/j.bbrc.2021.09.016
7KI0B1PeptideGlucagonGLP-1Homo sapiensSemaglutide-Gs/β1/γ22.52021-08-04doi.org/10.1016/j.celrep.2021.109374
7KI0 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensSemaglutide-2.52021-08-04doi.org/10.1016/j.celrep.2021.109374
7KI1B1PeptideGlucagonGLP-1Homo sapiensTaspoglutide-Gs/β1/γ22.52021-08-04doi.org/10.1016/j.celrep.2021.109374
7KI1 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTaspoglutide-2.52021-08-04doi.org/10.1016/j.celrep.2021.109374
6X18B1PeptideGlucagonGLP-1Homo sapiensGLP-1-Gs/β1/γ22.12020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X18 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1-2.12020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X19B1PeptideGlucagonGLP-1Homo sapiensCHU-128-Gs/β1/γ22.12020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X19 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensCHU-128-2.12020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X1AB1PeptideGlucagonGLP-1Homo sapiensDanuglipron-Gs/β1/γ22.52020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X1A (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensDanuglipron-2.52020-09-09doi.org/10.1016/j.molcel.2020.09.020
7LCIB1PeptideGlucagonGLP-1Homo sapiensDanuglipron-Gs/β1/γ22.92021-01-20doi.org/10.1016/j.str.2021.04.008
7LCI (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensDanuglipron-2.92021-01-20doi.org/10.1016/j.str.2021.04.008
7LCJB1PeptideGlucagonGLP-1Homo sapiensDanuglipron--2.822021-01-20doi.org/10.1016/j.str.2021.04.008
7LCKB1PeptideGlucagonGLP-1Homo sapiensDanuglipron--3.242021-01-20doi.org/10.1016/j.str.2021.04.008
7S15B1PeptideGlucagonGLP-1Homo sapiensPubChem 134611223--3.82022-06-08doi.org/10.1021/acs.jmedchem.1c01856
9J1PB1PeptideGlucagonGLP-1Homo sapiensg1:Ox-chim(NtGi1-Gs)/β1/γ22.992025-02-26doi.org/10.1021/jacs.4c12808
9J1P (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensg1:Ox-2.992025-02-26doi.org/10.1021/jacs.4c12808
5VAIB1PeptideGlucagonGLP-1Oryctolagus cuniculusGLP-1-Gs/β1/γ24.12017-05-24doi.org/10.1038/nature22394
5VAI (No Gprot) B1PeptideGlucagonGLP-1Oryctolagus cuniculusGLP-1-4.12017-05-24doi.org/10.1038/nature22394
5NX2B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)--3.72017-06-14doi.org/10.1038/nature22800
6B3JB1PeptideGlucagonGLP-1Homo sapiensExendin-P5-Gs/β1/γ23.32018-02-21doi.org/10.1038/nature25773
6B3J (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-P5-3.32018-02-21doi.org/10.1038/nature25773
8WG7B1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ22.542024-03-06doi.org/10.1038/s41421-024-00649-0
8WG7 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--2.542024-03-06doi.org/10.1038/s41421-024-00649-0
7C2EB1PeptideGlucagonGLP-1Homo sapiensPubChem 149050799-Gs/β1/γ24.22020-08-26doi.org/10.1038/s41422-020-0384-8
7C2E (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPubChem 149050799-4.22020-08-26doi.org/10.1038/s41422-020-0384-8
7LLLB1PeptideGlucagonGLP-1Homo sapiensExendin-4-Gs/β1/γ23.72022-01-12doi.org/10.1038/s41467-021-27760-0
7LLL (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-4-3.72022-01-12doi.org/10.1038/s41467-021-27760-0
7LLYB1PeptideGlucagonGLP-1Homo sapiensOxyntomodulin-Gs/β1/γ23.32022-01-12doi.org/10.1038/s41467-021-27760-0
7LLY (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOxyntomodulin-3.32022-01-12doi.org/10.1038/s41467-021-27760-0
7FIMB1PeptideGlucagonGLP-1Homo sapiensTirzepatide-Gs/β1/γ23.42022-03-02doi.org/10.1038/s41467-022-28683-0
7FIM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTirzepatide-3.42022-03-02doi.org/10.1038/s41467-022-28683-0
7VBIB1PeptideGlucagonGLP-1Homo sapiensNon-Acylated Tirzepatide-Gs/β1/γ232022-03-02doi.org/10.1038/s41467-022-28683-0
7VBI (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensNon-Acylated Tirzepatide-32022-03-02doi.org/10.1038/s41467-022-28683-0
7VBHB1PeptideGlucagonGLP-1Homo sapiensPeptide-20-Gs/β1/γ232022-04-06doi.org/10.1038/s41467-022-28683-0
7VBH (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-20-32022-04-06doi.org/10.1038/s41467-022-28683-0
7S1MB1PeptideGlucagonGLP-1Homo sapiensEx4-D-Ala-Gs/β1/γ22.412022-01-05doi.org/10.1038/s41589-021-00945-w
7S1M (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensEx4-D-Ala-2.412022-01-05doi.org/10.1038/s41589-021-00945-w
7S3IB1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ22.512022-01-05doi.org/10.1038/s41589-021-00945-w
7S3I (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--2.512022-01-05doi.org/10.1038/s41589-021-00945-w
6XOXB1PeptideGlucagonGLP-1Homo sapiensOrforglipron-chim(NtGi1-Gs)/β1/γ23.12020-11-18doi.org/10.1073/pnas.2014879117
6XOX (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOrforglipron-3.12020-11-18doi.org/10.1073/pnas.2014879117
7RG9B1PeptideGlucagonGLP-1Homo sapiens--chim(NtGi1-Gs)/β1/γ23.22022-04-13doi.org/10.1073/pnas.2116506119
7RG9 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--3.22022-04-13doi.org/10.1073/pnas.2116506119
7RGPB1PeptideGlucagonGLP-1Homo sapiensTirzepatide-chim(NtGi1-Gs)/β1/γ22.92022-04-13doi.org/10.1073/pnas.2116506119
7RGP (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTirzepatide-2.92022-04-13doi.org/10.1073/pnas.2116506119
7X8RB1PeptideGlucagonGLP-1Homo sapiensBOC5-Gs/β1/γ22.612022-06-29doi.org/10.1073/pnas.2200155119
7X8R (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensBOC5-2.612022-06-29doi.org/10.1073/pnas.2200155119
7X8SB1PeptideGlucagonGLP-1Homo sapiensWB4-24-Gs/β1/γ23.092022-06-29doi.org/10.1073/pnas.2200155119
7X8S (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensWB4-24-3.092022-06-29doi.org/10.1073/pnas.2200155119
8JIPB1PeptideGlucagonGLP-1Homo sapiensMEDI0382-chim(NtGi1-Gs)/β1/γ22.852023-09-06doi.org/10.1073/pnas.2303696120
8JIP (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensMEDI0382-2.852023-09-06doi.org/10.1073/pnas.2303696120
8JIRB1PeptideGlucagonGLP-1Homo sapiensSAR425899-chim(NtGi1-Gs)/β1/γ22.572023-09-06doi.org/10.1073/pnas.2303696120
8JIR (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensSAR425899-2.572023-09-06doi.org/10.1073/pnas.2303696120
8JISB1PeptideGlucagonGLP-1Homo sapiensPeptide-15-chim(NtGi1-Gs)/β1/γ22.462023-11-08doi.org/10.1073/pnas.2303696120
8JIS (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-15-2.462023-11-08doi.org/10.1073/pnas.2303696120
8YW3B1PeptideGlucagonGLP-1Homo sapiensRetatrutide-Gs/β1/γ22.682024-09-18doi.org/10.1038/s41421-024-00700-0
8YW3 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensRetatrutide-2.682024-09-18doi.org/10.1038/s41421-024-00700-0
9EBNB1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ23.442025-03-26doi.org/10.1073/pnas.2407574122
9EBN (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--3.442025-03-26doi.org/10.1073/pnas.2407574122
9EBOB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (ACPC18)-Gs/β1/γ23.132025-03-26doi.org/10.1073/pnas.2407574122
9EBO (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (ACPC18)-3.132025-03-26doi.org/10.1073/pnas.2407574122
9EBQB1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ23.162025-03-26doi.org/10.1073/pnas.2407574122
9EBQ (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--3.162025-03-26doi.org/10.1073/pnas.2407574122
8YWFB1PeptideGlucagonGLP-1Homo sapiensRetatrutide-chim(NtGi1-Gs)/β1/γ22.742025-04-16To be published
8YWF (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensRetatrutide-2.742025-04-16To be published
9BYOB1PeptideGlucagonGLP-1Homo sapiensExendin-3-Gs/β1/γ22.312025-06-11To be published
9BYO (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-3-2.312025-06-11To be published
9C0KB1PeptideGlucagonGLP-1Homo sapiensExendin-4-Gs/β1/γ22.722025-06-11To be published
9C0K (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-4-2.722025-06-11To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9EBN.zip



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