psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:P90	R:R:V30	5.3	Yes	No	2	4	2
2	R:R:S136	R:R:V30	4.85	No	No	2	1	2
3	R:R:P137	R:R:V30	8.84	Yes	No	2	3	2
4	R:R:E34	R:R:S31	11.5	No	No	0	4	4
5	R:R:L32	R:R:Q140	21.3	Yes	No	0	4	4
6	R:R:L144	R:R:L32	4.15	No	Yes	0	6	4
7	R:R:P137	R:R:T35	3.5	Yes	No	0	3	5
8	R:R:Q37	R:R:R40	2.34	No	No	0	4	2
9	R:R:L379	R:R:Q37	9.32	No	No	0	3	4
10	R:R:K38	R:R:W87	6.96	No	Yes	0	4	3
11	R:R:R43	R:R:W39	4	Yes	No	2	4	5
12	R:R:F66	R:R:W39	6.01	Yes	No	2	7	5
13	R:R:W39	R:R:Y88	18.33	No	Yes	2	5	5
14	R:R:E41	R:R:R44	17.45	No	No	0	4	3
15	R:R:E41	R:R:Q45	7.65	No	No	2	4	5
16	R:R:E41	R:R:W87	4.36	No	Yes	2	4	3
17	R:R:F66	R:R:Y42	3.09	Yes	Yes	2	7	6
18	R:R:C71	R:R:Y42	4.03	No	Yes	0	9	6
19	R:R:P86	R:R:Y42	11.13	Yes	Yes	2	8	6
20	R:R:W87	R:R:Y42	15.43	Yes	Yes	2	3	6
21	R:R:Y42	R:R:Y88	8.94	Yes	Yes	2	6	5
22	R:R:F66	R:R:R43	7.48	Yes	Yes	2	7	4
23	R:R:R44	R:R:R48	6.4	No	No	0	3	4
24	R:R:Q45	R:R:W87	12.05	No	Yes	2	5	3
25	R:R:C46	R:R:F66	5.59	No	Yes	0	8	7
26	R:R:C46	R:R:C71	7.28	No	No	0	8	9
27	R:R:L50	R:R:Q47	5.32	No	No	0	4	3
28	R:R:Q47	R:R:T51	7.09	No	No	0	3	4
29	R:R:E52	R:R:R48	15.12	No	No	0	2	4
30	R:R:D53	R:R:S49	2.94	No	No	0	3	2
31	R:R:L50	R:R:R64	3.64	No	Yes	0	4	4
32	R:R:D53	R:R:P54	4.83	No	No	0	3	2
33	R:R:D53	R:R:R64	3.57	No	Yes	0	3	4
34	R:R:P55	R:R:R64	2.88	No	Yes	0	1	4
35	R:R:P56	R:R:T58	5.25	No	No	7	1	1
36	R:R:F61	R:R:P56	10.11	Yes	No	7	3	1
37	R:R:D74	R:R:P56	9.66	No	No	7	3	1
38	R:R:F61	R:R:T58	6.49	Yes	No	7	3	1
39	R:R:G108	R:R:L60	3.42	No	No	0	9	1
40	R:R:F61	R:R:N63	2.42	Yes	No	0	3	4
41	R:R:D74	R:R:F61	2.39	No	Yes	7	3	3
42	R:R:C104	R:R:C62	7.28	No	No	2	9	9
43	R:R:C62	R:R:W110	16.98	No	Yes	2	9	9
44	R:R:D74	R:R:R64	16.68	No	Yes	0	3	4
45	R:R:R102	R:R:T65	3.88	Yes	No	0	8	5
46	R:R:E68	R:R:F66	7	No	Yes	0	4	7
47	R:R:D67	R:R:Y69	5.75	Yes	Yes	2	9	6
48	R:R:D67	R:R:W72	4.47	Yes	Yes	2	9	9
49	R:R:D67	R:R:R102	3.57	Yes	Yes	2	9	8
50	R:R:D67	R:R:R121	11.91	Yes	Yes	2	9	6
51	R:R:E68	R:R:R299	5.82	No	No	0	4	4
52	R:R:A70	R:R:Y69	4	No	Yes	2	5	6
53	R:R:P86	R:R:Y69	8.34	Yes	Yes	2	8	6
54	R:R:Y69	R:R:Y88	4.96	Yes	Yes	2	6	5
55	R:R:L89	R:R:Y69	3.52	Yes	Yes	2	5	6
56	R:R:L123	R:R:Y69	21.1	Yes	Yes	2	5	6
57	R:R:D215	R:R:Y69	3.45	No	Yes	0	3	6
58	R:R:A70	R:R:W72	3.89	No	Yes	2	5	9
59	R:R:A70	R:R:P86	3.74	No	Yes	2	5	8
60	R:R:V81	R:R:W72	2.45	No	Yes	0	6	9
61	R:R:V83	R:R:W72	13.48	No	Yes	0	5	9
62	R:R:V100	R:R:W72	2.45	No	Yes	0	7	9
63	R:R:R102	R:R:W72	21.99	Yes	Yes	2	8	9
64	R:R:P73	R:R:V81	3.53	No	No	0	5	6
65	R:R:C104	R:R:G75	3.92	No	No	2	9	7
66	R:R:G75	R:R:W110	2.81	No	Yes	2	7	9
67	R:R:E76	R:R:S79	4.31	No	No	0	1	5
68	R:R:F103	R:R:G78	4.52	Yes	No	0	4	7
69	R:R:F103	R:R:F80	10.72	Yes	No	0	4	4
70	R:R:F80	R:R:W120	5.01	No	Yes	0	4	5
71	H:H:?1	R:R:F80	11.95	No	No	0	0	4
72	R:R:V81	R:R:W110	6.13	No	Yes	0	6	9
73	R:R:N82	R:R:Y101	17.44	No	Yes	3	4	5
74	H:H:?1	R:R:N82	25.72	No	No	3	0	4
75	R:R:C85	R:R:P86	3.77	Yes	Yes	0	9	8
76	R:R:C85	R:R:G98	3.92	Yes	No	0	9	4
77	R:R:C85	R:R:V100	3.42	Yes	No	0	9	7
78	R:R:C126	R:R:C85	7.28	No	Yes	0	9	9
79	R:R:P86	R:R:Y88	12.52	Yes	Yes	2	8	5
80	R:R:L89	R:R:P86	4.93	Yes	Yes	2	5	8
81	R:R:L89	R:R:Y88	3.52	Yes	Yes	2	5	5
82	R:R:L89	R:R:P90	4.93	Yes	Yes	2	5	4
83	R:R:L89	R:R:W91	9.11	Yes	Yes	2	5	4
84	R:R:P90	R:R:W91	4.05	Yes	Yes	2	4	4
85	R:R:P90	R:R:S135	5.34	Yes	Yes	2	4	1
86	R:R:P137	R:R:P90	7.79	Yes	Yes	2	3	4
87	R:R:S135	R:R:W91	3.71	Yes	Yes	2	1	4
88	R:R:E138	R:R:W91	6.54	No	Yes	2	2	4
89	R:R:S94	R:R:V95	3.23	No	No	0	4	5
90	R:R:C126	R:R:V95	3.42	No	No	0	9	5
91	R:R:H99	R:R:Q97	2.47	Yes	No	0	4	4
92	R:R:G98	R:R:H99	3.18	No	Yes	0	4	4
93	R:R:H99	R:R:Y101	10.89	Yes	Yes	3	4	5
94	R:R:E125	R:R:H99	4.92	Yes	Yes	3	5	4
95	R:R:L123	R:R:V100	4.47	Yes	No	0	5	7
96	R:R:D122	R:R:Y101	5.75	Yes	Yes	3	7	5
97	R:R:E125	R:R:Y101	5.61	Yes	Yes	3	5	5
98	H:H:?1	R:R:Y101	6.27	No	Yes	3	0	5
99	R:R:R102	R:R:W110	18.99	Yes	Yes	2	8	9
100	R:R:P119	R:R:R102	10.09	Yes	Yes	2	6	8
101	R:R:F103	R:R:T105	2.59	Yes	Yes	3	4	4
102	R:R:F103	R:R:L111	3.65	Yes	Yes	3	4	4
103	R:R:C104	R:R:W110	2.61	No	Yes	2	9	9
104	R:R:E107	R:R:T105	8.47	No	Yes	3	5	4
105	R:R:L109	R:R:T105	4.42	No	Yes	3	5	4
106	R:R:L111	R:R:T105	2.95	Yes	Yes	3	4	4
107	R:R:E107	R:R:L109	2.65	No	No	3	5	5
108	R:R:P119	R:R:W110	2.7	Yes	Yes	2	6	9
109	R:R:K113	R:R:L111	4.23	No	Yes	3	4	4
110	R:R:L111	R:R:W120	5.69	Yes	Yes	3	4	5
111	R:R:N115	R:R:Q112	3.96	No	No	0	4	3
112	R:R:P119	R:R:Q112	3.16	Yes	No	0	6	3
113	R:R:K113	R:R:W120	12.76	No	Yes	3	4	5
114	R:R:D114	R:R:S116	5.89	No	No	0	4	5
115	R:R:D114	R:R:S117	8.83	No	No	0	4	7
116	R:R:S116	R:R:Y220	7.63	No	No	0	5	3
117	R:R:L118	R:R:S117	3	Yes	No	0	4	7
118	R:R:L118	R:R:P119	3.28	Yes	Yes	2	4	6
119	R:R:L118	R:R:R121	20.65	Yes	Yes	2	4	6
120	R:R:H212	R:R:L118	3.86	No	Yes	2	3	4
121	R:R:G216	R:R:L118	5.13	No	Yes	0	2	4
122	R:R:D122	R:R:W120	5.58	Yes	Yes	3	7	5
123	R:R:L123	R:R:R121	2.43	Yes	Yes	2	5	6
124	R:R:H212	R:R:R121	28.21	No	Yes	2	3	6
125	R:R:D122	R:R:S124	10.31	Yes	No	3	7	5
126	R:R:D122	R:R:E125	6.5	Yes	Yes	3	7	5
127	R:R:H212	R:R:L123	3.86	No	Yes	2	3	5
128	R:R:E125	R:R:S124	10.06	Yes	No	3	5	5
129	R:R:E127	R:R:Q211	17.84	No	No	0	2	4
130	R:R:P137	R:R:S135	5.34	Yes	Yes	2	3	1
131	R:R:E138	R:R:S135	5.75	No	Yes	2	2	1
132	R:R:P137	R:R:S136	3.56	Yes	No	2	3	1
133	R:R:F143	R:R:L144	6.09	No	No	0	4	6
134	R:R:F143	R:R:I147	3.77	No	No	0	4	6
135	R:R:Y145	R:R:Y148	8.94	Yes	Yes	5	5	7
136	R:R:T149	R:R:Y145	7.49	No	Yes	5	7	5
137	R:R:D198	R:R:Y145	5.75	No	Yes	0	7	5
138	R:R:L201	R:R:Y145	2.34	No	Yes	0	7	5
139	R:R:T149	R:R:Y148	3.75	No	Yes	5	7	7
140	R:R:Y148	R:R:Y152	7.94	Yes	Yes	5	7	7
141	R:R:V194	R:R:Y148	6.31	No	Yes	5	7	7
142	R:R:G151	R:R:S392	3.71	No	No	5	8	9
143	R:R:F393	R:R:G151	9.03	No	No	5	7	8
144	R:R:S155	R:R:Y152	2.54	No	Yes	0	9	7
145	R:R:R190	R:R:Y152	7.2	Yes	Yes	0	8	7
146	R:R:V194	R:R:Y152	16.4	No	Yes	5	7	7
147	R:R:S392	R:R:Y152	8.9	No	Yes	5	9	7
148	R:R:F393	R:R:L154	2.44	No	No	0	7	5
149	R:R:L154	R:R:L396	4.15	No	No	0	5	7
150	R:R:G395	R:R:S155	3.71	No	No	0	9	9
151	R:R:F156	R:R:V160	7.87	Yes	No	8	7	3
152	R:R:F156	R:R:I188	7.54	Yes	Yes	8	7	7
153	R:R:A191	R:R:F156	4.16	No	Yes	0	7	7
154	R:R:F156	R:R:L192	2.44	Yes	No	0	7	3
155	R:R:F156	R:R:F195	5.36	Yes	No	0	7	7
156	R:R:A158	R:R:L396	3.15	No	No	0	7	7
157	R:R:A158	R:R:F404	2.77	No	No	0	7	8
158	R:R:I188	R:R:L159	2.85	Yes	No	0	7	9
159	R:R:A399	R:R:L159	4.73	No	No	0	8	9
160	R:R:I188	R:R:V160	4.61	Yes	No	8	7	3
161	R:R:A162	R:R:F184	2.77	No	Yes	0	9	8
162	R:R:A162	R:R:C403	3.61	No	No	0	9	9
163	R:R:A162	R:R:F404	2.77	No	No	0	9	8
164	R:R:F184	R:R:S163	5.28	Yes	No	0	8	6
165	R:R:I188	R:R:S163	3.1	Yes	No	0	7	6
166	R:R:C403	R:R:I165	6.55	No	No	0	9	8
167	R:R:I165	R:R:V409	3.07	No	No	0	8	9
168	R:R:L166	R:R:L172	5.54	Yes	Yes	1	8	9
169	R:R:L166	R:R:N177	12.36	Yes	Yes	1	8	9
170	R:R:L166	R:R:L181	8.3	Yes	No	0	8	6
171	R:R:F184	R:R:L166	4.87	Yes	Yes	0	8	8
172	R:R:L167	R:R:L181	6.92	No	No	0	3	6
173	R:R:F169	R:R:L172	3.65	No	Yes	0	7	9
174	R:R:E412	R:R:F169	18.66	No	No	0	8	7
175	R:R:H173	R:R:R170	4.51	No	No	0	7	8
176	R:R:E412	R:R:H171	8.62	No	No	0	8	7
177	R:R:L172	R:R:N177	5.49	Yes	Yes	1	9	9
178	R:R:L172	R:R:V409	2.98	Yes	No	0	9	9
179	R:R:H173	R:R:Y178	6.53	No	No	0	7	6
180	R:R:C174	R:R:R176	2.79	No	Yes	1	8	9
181	R:R:C174	R:R:N177	4.72	No	Yes	1	8	9
182	R:R:T175	R:R:Y250	2.5	No	Yes	1	7	8
183	R:R:E262	R:R:T175	12.7	No	No	1	6	7
184	R:R:N177	R:R:R176	10.85	Yes	Yes	1	9	9
185	R:R:H180	R:R:R176	3.39	Yes	Yes	1	9	9
186	R:R:R176	R:R:Y250	8.23	Yes	Yes	1	9	8
187	R:R:L349	R:R:R176	7.29	Yes	Yes	1	9	9
188	R:R:N406	R:R:R176	6.03	Yes	Yes	1	9	9
189	R:R:E408	R:R:R176	3.49	Yes	Yes	1	9	9
190	R:R:F266	R:R:Y178	4.13	Yes	No	0	6	6
191	R:R:I179	R:R:W243	3.52	Yes	Yes	1	8	9
192	R:R:E247	R:R:I179	5.47	Yes	Yes	1	9	8
193	R:R:I179	R:R:Y250	7.25	Yes	Yes	1	8	8
194	R:R:F266	R:R:I179	5.02	Yes	Yes	0	6	8
195	R:R:I179	R:R:Y269	3.63	Yes	Yes	1	8	7
196	R:R:F184	R:R:H180	3.39	Yes	Yes	0	8	9
197	R:R:E247	R:R:H180	12.31	Yes	Yes	1	9	9
198	R:R:H180	R:R:L349	7.71	Yes	Yes	1	9	9
199	R:R:H180	R:R:Y402	15.24	Yes	Yes	1	9	8
200	R:R:N182	R:R:W243	20.34	No	Yes	1	9	9
201	R:R:F266	R:R:N182	2.42	Yes	No	0	6	9
202	R:R:N182	R:R:W274	11.3	No	Yes	1	9	9
203	R:R:F187	R:R:L183	2.44	Yes	Yes	1	8	9
204	R:R:L183	R:R:W243	3.42	Yes	Yes	1	9	9
205	R:R:E247	R:R:L183	7.95	Yes	Yes	1	9	9
206	R:R:L183	R:R:V398	2.98	Yes	Yes	1	9	9
207	R:R:L183	R:R:Y402	2.34	Yes	Yes	1	9	8
208	R:R:F184	R:R:V398	2.62	Yes	Yes	0	8	9
209	R:R:A185	R:R:W274	2.59	No	Yes	0	3	9
210	R:R:A239	R:R:S186	3.42	No	No	1	8	9
211	R:R:N240	R:R:S186	7.45	No	No	0	9	9
212	R:R:S186	R:R:W274	2.47	No	Yes	1	9	9
213	R:R:F187	R:R:N240	26.58	Yes	No	0	8	9
214	R:R:F187	R:R:Q394	8.2	Yes	Yes	0	8	9
215	R:R:F187	R:R:G395	4.52	Yes	No	0	8	9
216	R:R:F187	R:R:V398	5.24	Yes	Yes	1	8	9
217	R:R:L189	R:R:L192	5.54	No	No	0	7	3
218	R:R:C236	R:R:R190	4.18	No	Yes	0	5	8
219	R:R:R190	R:R:V237	3.92	Yes	No	0	8	6
220	R:R:N240	R:R:R190	7.23	No	Yes	0	9	8
221	R:R:Q394	R:R:R190	11.68	Yes	Yes	0	9	8
222	R:R:F196	R:R:L192	4.87	No	No	0	5	3
223	R:R:C193	R:R:L232	4.76	No	No	0	6	5
224	R:R:F195	R:R:V194	2.62	No	No	0	7	7
225	R:R:C226	R:R:K197	6.47	No	No	0	9	6
226	R:R:D198	R:R:K202	8.3	No	No	0	7	4
227	R:R:A200	R:R:Q221	4.55	No	Yes	0	4	4
228	R:R:K202	R:R:L201	5.64	No	No	0	4	7
229	R:R:M204	R:R:W203	3.49	Yes	No	6	3	3
230	R:R:Q221	R:R:W203	3.29	Yes	No	6	4	3
231	R:R:L217	R:R:M204	2.83	Yes	Yes	6	4	3
232	R:R:M204	R:R:Y220	9.58	Yes	No	0	3	3
233	R:R:M204	R:R:Q221	19.03	Yes	Yes	6	3	4
234	R:R:Q213	R:R:Y205	3.38	No	No	0	4	3
235	R:R:W214	R:R:Y205	24.12	No	No	6	1	3
236	R:R:L217	R:R:Y205	14.07	Yes	No	6	4	3
237	R:R:A208	R:R:Q213	3.03	No	No	0	4	4
238	R:R:Q210	R:R:Q213	6.4	No	No	0	4	4
239	R:R:L217	R:R:W214	2.28	Yes	No	6	4	1
240	R:R:L218	R:R:W214	2.28	No	No	6	3	1
241	R:R:L217	R:R:L218	5.54	Yes	No	6	4	3
242	R:R:L224	R:R:Y220	5.86	No	No	0	3	3
243	R:R:A225	R:R:Q221	4.55	No	Yes	0	3	4
244	R:R:C226	R:R:D222	3.11	No	No	4	9	6
245	R:R:C296	R:R:D222	4.67	Yes	No	4	9	6
246	R:R:L224	R:R:S223	3	No	No	0	3	4
247	R:R:L224	R:R:R227	9.72	No	No	0	3	8
248	R:R:C226	R:R:C296	7.28	No	Yes	4	9	9
249	R:R:L228	R:R:R227	4.86	No	No	0	4	8
250	R:R:F230	R:R:Q234	4.68	No	No	4	5	7
251	R:R:F230	R:R:W284	5.01	No	Yes	4	5	8
252	R:R:C296	R:R:F230	4.19	Yes	No	4	9	5
253	R:R:L231	R:R:V281	2.98	No	No	0	5	6
254	R:R:L231	R:R:W284	2.28	No	Yes	0	5	8
255	R:R:L231	R:R:W297	2.28	No	Yes	0	5	8
256	R:R:L232	R:R:Y235	2.34	No	Yes	0	5	9
257	R:R:Q234	R:R:W284	3.29	No	Yes	4	7	8
258	R:R:I309	R:R:Q234	4.12	No	No	4	7	7
259	R:R:W274	R:R:Y235	7.72	Yes	Yes	0	9	9
260	R:R:P277	R:R:Y235	4.17	Yes	Yes	0	9	9
261	R:R:L278	R:R:Y235	11.72	No	Yes	0	3	9
262	R:R:V281	R:R:Y235	7.57	No	Yes	0	6	9
263	R:R:V237	R:R:Y241	2.52	No	Yes	0	6	8
264	R:R:A238	R:R:P277	3.74	No	Yes	0	6	9
265	R:R:A238	R:R:F280	4.16	No	Yes	0	6	5
266	R:R:A239	R:R:W274	3.89	No	Yes	1	8	9
267	R:R:I313	R:R:Y241	3.63	No	Yes	0	7	8
268	R:R:C317	R:R:Y241	2.69	No	Yes	10	7	8
269	R:R:C361	R:R:Y241	2.69	No	Yes	10	9	8
270	R:R:H363	R:R:Y241	4.36	No	Yes	0	8	8
271	R:R:L245	R:R:Y242	2.34	Yes	Yes	0	8	6
272	R:R:V276	R:R:Y242	8.83	No	Yes	4	3	6
273	R:R:P277	R:R:Y242	6.95	Yes	Yes	4	9	6
274	R:R:F280	R:R:Y242	6.19	Yes	Yes	4	5	6
275	R:R:A316	R:R:Y242	6.67	No	Yes	0	7	6
276	R:R:V246	R:R:W243	3.68	No	Yes	0	8	9
277	R:R:V270	R:R:W243	6.13	No	Yes	1	5	9
278	R:R:G273	R:R:W243	8.44	No	Yes	0	9	9
279	R:R:W243	R:R:W274	21.56	Yes	Yes	1	9	9
280	R:R:L244	R:R:N320	10.98	No	No	1	9	9
281	R:R:I357	R:R:L244	5.71	Yes	No	1	8	9
282	R:R:L245	R:R:V249	2.98	Yes	No	0	8	6
283	R:R:L245	R:R:V319	2.98	Yes	No	0	8	6
284	R:R:L245	R:R:N320	9.61	Yes	No	0	8	9
285	R:R:V246	R:R:Y269	7.57	No	Yes	0	8	7
286	R:R:I272	R:R:V246	4.61	No	No	0	6	8
287	R:R:E247	R:R:Y402	16.83	Yes	Yes	1	9	8
288	R:R:V249	R:R:Y269	5.05	No	Yes	0	6	7
289	R:R:T253	R:R:Y250	3.75	No	Yes	1	7	8
290	R:R:L254	R:R:Y250	11.72	No	Yes	1	8	8
291	R:R:E262	R:R:Y250	5.61	No	Yes	1	6	8
292	R:R:Y250	R:R:Y269	5.96	Yes	Yes	1	8	7
293	R:R:L349	R:R:Y250	2.34	Yes	Yes	1	9	8
294	R:R:L251	R:R:V327	2.98	Yes	No	0	9	9
295	R:R:L251	R:R:L349	4.15	Yes	Yes	1	9	9
296	R:R:A350	R:R:L251	3.15	No	Yes	0	8	9
297	R:R:L251	R:R:T353	7.37	Yes	Yes	1	9	9
298	R:R:A256	R:R:Y252	5.34	No	Yes	0	6	8
299	R:R:I323	R:R:Y252	3.63	No	Yes	0	8	8
300	R:R:I330	R:R:Y252	2.42	No	Yes	0	9	8
301	R:R:T253	R:R:Y269	3.75	No	Yes	1	7	7
302	R:R:E262	R:R:L254	3.98	No	No	1	6	8
303	R:R:I330	R:R:L255	2.85	No	No	1	9	8
304	R:R:K334	R:R:L255	5.64	No	No	1	9	8
305	R:R:L255	R:R:M340	2.83	No	Yes	1	8	5
306	R:R:I265	R:R:W264	7.05	No	No	0	5	5
307	R:R:R267	R:R:W264	4	No	No	0	4	5
308	R:R:L268	R:R:W264	4.56	No	No	0	2	5
309	R:R:I265	R:R:Y269	7.25	No	Yes	0	5	7
310	R:R:F266	R:R:V270	6.55	Yes	No	0	6	5
311	R:R:V270	R:R:W274	2.45	No	Yes	1	5	9
312	R:R:P277	R:R:V276	3.53	Yes	No	4	9	3
313	R:R:F280	R:R:V276	2.62	Yes	No	4	5	3
314	R:R:F280	R:R:V281	2.62	Yes	No	0	5	6
315	R:R:F280	R:R:I309	2.51	Yes	No	4	5	7
316	R:R:F280	R:R:P312	18.78	Yes	No	0	5	8
317	R:R:F280	R:R:I313	3.77	Yes	No	0	5	7
318	R:R:P283	R:R:V282	5.3	No	No	0	5	3
319	R:R:I286	R:R:V282	3.07	No	No	0	4	3
320	R:R:G285	R:R:W284	5.63	No	Yes	0	5	8
321	R:R:K288	R:R:W284	23.21	No	Yes	0	8	8
322	R:R:I308	R:R:W284	5.87	No	Yes	0	8	8
323	R:R:I309	R:R:W284	7.05	No	Yes	4	7	8
324	R:R:G285	R:R:W297	4.22	No	Yes	0	5	8
325	R:R:I286	R:R:L290	2.85	No	No	0	4	3
326	R:R:V287	R:R:Y291	5.05	No	No	0	4	3
327	R:R:V287	R:R:Y305	6.31	No	No	0	4	4
328	R:R:K288	R:R:W297	8.12	No	Yes	0	8	8
329	R:R:K288	R:R:N300	8.39	No	No	0	8	6
330	R:R:D293	R:R:Y289	5.75	No	No	9	7	3
331	R:R:W297	R:R:Y289	3.86	Yes	No	9	8	3
332	R:R:L290	R:R:Y291	3.52	No	No	0	3	3
333	R:R:E292	R:R:E294	3.81	No	No	0	6	4
334	R:R:D293	R:R:W297	3.35	No	Yes	9	7	8
335	R:R:E294	R:R:G295	3.27	No	No	0	4	4
336	R:R:G295	R:R:R299	3	No	No	0	4	4
337	R:R:C296	R:R:T298	3.38	Yes	No	0	9	5
338	R:R:N300	R:R:W306	5.65	No	Yes	0	6	6
339	R:R:M303	R:R:Y305	4.79	No	No	0	5	4
340	R:R:N304	R:R:W306	5.65	No	Yes	0	3	6
341	R:R:L307	R:R:N304	6.87	No	No	0	7	3
342	R:R:R310	R:R:W306	6	Yes	Yes	0	6	6
343	R:R:F381	R:R:W306	7.02	No	Yes	0	4	6
344	R:R:L307	R:R:R310	4.86	No	Yes	0	7	6
345	R:R:L311	R:R:R310	2.43	No	Yes	0	4	6
346	R:R:D372	R:R:R310	8.34	No	Yes	0	5	6
347	R:R:E364	R:R:I313	5.47	No	No	0	8	7
348	R:R:I318	R:R:L314	5.71	No	Yes	0	4	4
349	R:R:E364	R:R:L314	7.95	No	Yes	0	8	4
350	R:R:A368	R:R:L314	6.3	No	Yes	0	6	4
351	R:R:F315	R:R:V319	2.62	No	No	0	4	6
352	R:R:C317	R:R:C361	7.28	No	No	10	7	9
353	R:R:C317	R:R:E364	12.15	No	No	0	7	8
354	R:R:I357	R:R:N320	5.66	Yes	No	1	8	9
355	R:R:C361	R:R:F321	4.19	No	No	0	9	6
356	R:R:F321	R:R:T362	3.89	No	No	0	6	7
357	R:R:F321	R:R:V365	6.55	No	No	0	6	6
358	R:R:F324	R:R:I328	5.02	Yes	No	1	9	7
359	R:R:F324	R:R:L354	7.31	Yes	No	1	9	8
360	R:R:F324	R:R:I357	6.28	Yes	Yes	1	9	8
361	R:R:F324	R:R:P358	7.22	Yes	No	1	9	9
362	R:R:L354	R:R:V327	5.96	No	No	0	8	9
363	R:R:I328	R:R:L354	4.28	No	No	1	7	8
364	R:R:I328	W:W:?2	3.85	No	Yes	1	7	0
365	R:R:I330	R:R:K334	5.82	No	No	1	9	9
366	R:R:L335	R:R:V331	2.98	No	Yes	1	8	8
367	R:R:M340	R:R:V331	6.09	Yes	Yes	1	5	8
368	R:R:F347	R:R:V331	2.62	Yes	Yes	1	7	8
369	R:R:V331	W:W:?2	5.02	Yes	Yes	1	8	0
370	R:R:K334	R:R:M340	11.52	No	Yes	1	9	5
371	R:R:K342	R:R:L335	4.23	No	No	1	5	8
372	R:R:F347	R:R:L335	2.44	Yes	No	1	7	8
373	R:R:A337	R:R:L339	3.15	No	No	0	7	7
374	R:R:F347	R:R:M340	2.49	Yes	Yes	1	7	5
375	R:R:F347	R:R:K342	14.89	Yes	No	1	7	5
376	R:R:E408	R:R:I345	4.1	Yes	No	0	9	5
377	R:R:F347	R:R:K351	8.69	Yes	No	1	7	8
378	R:R:F347	W:W:?2	7.39	Yes	Yes	1	7	0
379	R:R:K351	R:R:R348	8.66	No	No	1	8	8
380	R:R:N407	R:R:R348	12.05	Yes	No	1	6	8
381	R:R:R348	W:W:?2	4.1	No	Yes	1	8	0
382	R:R:L349	R:R:T353	2.95	Yes	Yes	1	9	9
383	R:R:L349	R:R:Y402	3.52	Yes	Yes	1	9	8
384	R:R:L349	W:W:?2	2.8	Yes	Yes	1	9	0
385	R:R:K351	W:W:?2	35.19	No	Yes	1	8	0
386	R:R:L401	R:R:S352	4.5	Yes	No	1	8	9
387	R:R:S352	R:R:Y402	10.17	No	Yes	1	9	8
388	R:R:S352	W:W:?2	6.08	No	Yes	1	9	0
389	R:R:I357	R:R:T353	3.04	Yes	Yes	1	8	9
390	R:R:T353	R:R:Y402	7.49	Yes	Yes	1	9	8
391	R:R:L401	R:R:T355	2.95	Yes	No	1	8	8
392	R:R:T355	W:W:?2	10.94	No	Yes	1	8	0
393	R:R:L356	R:R:V398	5.96	No	Yes	1	9	9
394	R:R:L356	R:R:L401	4.15	No	Yes	1	9	8
395	R:R:L356	R:R:Y402	4.69	No	Yes	1	9	8
396	R:R:I357	R:R:P358	3.39	Yes	No	1	8	9
397	R:R:L359	R:R:L360	4.15	No	No	0	9	9
398	R:R:L360	R:R:Q394	7.99	No	Yes	0	9	9
399	R:R:F367	R:R:H363	2.26	No	No	0	7	8
400	R:R:F367	R:R:I366	8.79	No	No	0	7	6
401	R:R:F367	R:R:M371	3.73	No	No	0	7	7
402	R:R:G377	R:R:M371	3.49	No	No	11	4	7
403	R:R:M371	R:R:R380	26.06	No	No	11	7	5
404	R:R:E373	R:R:H374	19.69	No	No	0	4	3
405	R:R:R376	R:R:T378	10.35	No	No	0	5	2
406	R:R:L379	R:R:R376	4.86	No	No	0	3	5
407	R:R:G377	R:R:R380	4.5	No	No	11	4	5
408	R:R:I382	R:R:L379	4.28	No	No	0	4	3
409	R:R:K383	R:R:T386	3	No	No	0	7	4
410	R:R:D387	R:R:K383	5.53	No	No	0	8	7
411	R:R:L384	R:R:L388	2.77	No	No	0	5	7
412	R:R:F390	R:R:T391	3.89	No	No	0	6	6
413	R:R:Q394	R:R:T391	9.92	Yes	No	0	9	6
414	R:R:F393	R:R:S392	3.96	No	No	5	7	9
415	R:R:I400	R:R:L396	5.71	No	No	0	6	7
416	R:R:V398	R:R:Y402	2.52	Yes	Yes	1	9	8
417	R:R:F404	R:R:I400	10.05	No	No	0	8	6
418	R:R:L401	W:W:?2	2.8	Yes	Yes	1	8	0
419	R:R:V405	W:W:?2	12.06	No	Yes	0	6	0
420	R:R:E408	R:R:N406	7.89	Yes	Yes	1	9	9
421	R:R:N406	R:R:V409	4.43	Yes	No	0	9	9
422	R:R:N406	W:W:?2	12.97	Yes	Yes	1	9	0
423	R:R:E408	R:R:N407	2.63	Yes	Yes	1	9	6
424	R:R:N407	W:W:?2	5.56	Yes	Yes	1	6	0
425	R:R:L411	R:R:R414	10.93	No	No	0	4	6
426	R:R:E412	R:R:K415	2.7	No	No	0	8	7
427	R:R:E418	R:R:K415	8.1	No	No	0	4	7
428	R:R:S416	R:R:W417	2.47	No	No	0	5	5
429	R:R:E127	R:R:W91	2.18	No	Yes	0	2	4
430	R:R:R40	R:R:R43	2.13	No	Yes	0	2	4
431	R:R:G275	R:R:P277	2.03	No	Yes	0	6	9
432	R:R:V332	W:W:?2	2.01	No	Yes	0	6	0
433	R:R:F413	R:R:W417	2	No	No	0	5	5
434	R:R:C296	R:R:G295	1.96	Yes	No	0	9	4
435	R:R:G78	R:R:S79	1.86	No	No	0	7	5
436	R:R:G216	R:R:S219	1.86	No	No	0	2	5
437	R:R:G151	R:R:V150	1.84	No	No	0	8	5
438	R:R:C193	R:R:C233	1.82	No	No	0	6	6
439	R:R:G248	R:R:T353	1.82	No	Yes	0	8	9
440	R:R:P96	R:R:V95	1.77	No	No	0	3	5
441	R:R:C71	R:R:S49	1.72	No	No	0	9	2
442	R:R:C193	R:R:V229	1.71	No	No	0	6	7
443	R:R:I308	R:R:P283	1.69	No	No	0	8	5
444	R:R:C341	R:R:T343	1.69	No	No	0	4	5
445	R:R:A375	R:R:T378	1.68	No	No	0	4	2
446	R:R:L32	R:R:P137	1.64	Yes	Yes	0	4	3
447	R:R:L60	R:R:P77	1.64	No	No	0	1	4
448	R:R:S333	R:R:V332	1.62	No	No	0	7	6
449	R:R:A346	R:R:I345	1.62	No	No	0	6	5
450	R:R:T35	R:R:V36	1.59	No	No	0	5	2
451	R:R:A92	R:R:L89	1.58	No	Yes	0	5	5
452	R:R:E76	R:R:P77	1.57	No	No	0	1	4
453	R:R:C341	R:R:D344	1.56	No	No	0	4	7
454	R:R:I146	R:R:V150	1.54	No	No	0	4	5
455	R:R:A106	R:R:E107	1.51	No	No	0	1	5
456	R:R:L32	R:R:S31	1.5	Yes	No	0	4	4
457	R:R:L322	R:R:V319	1.49	No	No	0	5	6
458	R:R:I161	R:R:I165	1.47	No	No	0	4	8
459	R:R:D387	R:R:T391	1.45	No	No	0	8	6
460	R:R:L359	R:R:M397	1.41	No	No	0	9	5
461	R:R:L401	R:R:M397	1.41	Yes	No	0	8	5
462	R:R:A153	R:R:F195	1.39	No	No	0	6	7
463	R:R:C329	R:R:R326	1.39	No	No	0	7	8
464	R:R:D387	R:R:L384	1.36	No	No	0	8	5
465	R:R:R43	R:R:S301	1.32	Yes	No	0	4	3
466	R:R:F169	R:R:S416	1.32	No	No	0	7	5
467	R:R:N407	R:R:Q410	1.32	Yes	No	0	6	7
468	R:R:F324	R:R:V325	1.31	Yes	No	0	9	5
469	R:R:S389	R:R:Y148	1.27	No	Yes	0	5	7
470	R:R:S31	R:R:W33	1.24	No	No	0	4	3
471	R:R:F369	R:R:L314	1.22	No	Yes	0	4	4
472	R:R:R326	R:R:Y252	1.03	No	Yes	0	8	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L32	7.1475	4	0	4
2	R:R:Y42	8.524	5	2	6
3	R:R:R43	3.7325	4	2	4
4	R:R:F61	5.3525	4	7	3
5	R:R:R64	6.6925	4	0	4
6	R:R:F66	5.834	5	2	7
7	R:R:D67	6.425	4	2	9
8	R:R:Y69	7.30286	7	2	6
9	R:R:W72	8.12167	6	2	9
10	R:R:C85	4.5975	4	0	9
11	R:R:P86	7.405	6	2	8
12	R:R:W87	9.7	4	2	3
13	R:R:Y88	9.654	5	2	5
14	R:R:L89	4.59833	6	2	5
15	R:R:P90	5.482	5	2	4
16	R:R:W91	5.118	5	2	4
17	R:R:H99	5.365	4	3	4
18	R:R:Y101	9.192	5	3	5
19	R:R:R102	11.704	5	2	8
20	R:R:F103	5.37	4	3	4
21	R:R:T105	4.6075	4	3	4
22	R:R:W110	8.37	6	2	9
23	R:R:L111	4.13	4	3	4
24	R:R:L118	7.184	5	2	4
25	R:R:P119	4.8075	4	2	6
26	R:R:W120	7.26	4	3	5
27	R:R:R121	15.8	4	2	6
28	R:R:D122	7.035	4	3	7
29	R:R:L123	7.965	4	2	5
30	R:R:E125	6.7725	4	3	5
31	R:R:S135	5.035	4	2	1
32	R:R:P137	5.11167	6	2	3
33	R:R:Y145	6.13	4	5	5
34	R:R:Y148	5.642	5	5	7
35	R:R:Y152	8.596	5	5	7
36	R:R:F156	5.474	5	8	7
37	R:R:L166	7.7675	4	1	8
38	R:R:L172	4.415	4	1	9
39	R:R:R176	6.01	7	1	9
40	R:R:N177	8.355	4	1	9
41	R:R:I179	4.978	5	1	8
42	R:R:H180	8.408	5	1	9
43	R:R:L183	3.826	5	1	9
44	R:R:F184	3.786	5	0	8
45	R:R:F187	9.396	5	1	8
46	R:R:I188	4.525	4	8	7
47	R:R:R190	6.842	5	0	8
48	R:R:M204	8.7325	4	6	3
49	R:R:L217	6.18	4	6	4
50	R:R:Q221	7.855	4	6	4
51	R:R:Y235	6.704	5	0	9
52	R:R:Y241	3.178	5	10	8
53	R:R:Y242	6.196	5	4	6
54	R:R:W243	9.58428	7	1	9
55	R:R:L245	4.4775	4	0	8
56	R:R:E247	10.64	4	1	9
57	R:R:Y250	5.92	8	1	8
58	R:R:L251	4.4125	4	1	9
59	R:R:Y252	3.105	4	0	8
60	R:R:F266	4.53	4	0	6
61	R:R:Y269	5.535	6	1	7
62	R:R:W274	7.42571	7	1	9
63	R:R:P277	4.084	5	4	9
64	R:R:F280	5.80714	7	4	5
65	R:R:W284	7.47714	7	4	8
66	R:R:C296	4.296	5	4	9
67	R:R:W297	4.366	5	9	8
68	R:R:W306	6.08	4	0	6
69	R:R:R310	5.4075	4	0	6
70	R:R:L314	5.295	4	0	4
71	R:R:F324	5.428	5	1	9
72	R:R:V331	4.1775	4	1	8
73	R:R:M340	5.7325	4	1	5
74	R:R:F347	6.42	6	1	7
75	R:R:L349	4.39429	7	1	9
76	R:R:T353	4.534	5	1	9
77	R:R:I357	4.816	5	1	8
78	R:R:Q394	9.4475	4	0	9
79	R:R:V398	3.864	5	1	9
80	R:R:L401	3.162	5	1	8
81	R:R:Y402	7.85	8	1	8
82	R:R:N406	7.83	4	1	9
83	R:R:N407	5.39	4	1	6
84	R:R:E408	4.5275	4	1	9
85	W:W:?2	8.52077	13	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L89	R:R:P90	11.8376	4.93	Yes	Yes	2	5	4
2	R:R:L89	R:R:Y88	10.6689	3.52	Yes	Yes	2	5	5
3	R:R:W39	R:R:Y88	25.213	18.33	No	Yes	2	5	5
4	R:R:P86	R:R:Y42	39.69	11.13	Yes	Yes	2	8	6
5	R:R:Y42	R:R:Y88	25.4907	8.94	Yes	Yes	2	6	5
6	R:R:F66	R:R:W39	24.972	6.01	Yes	No	2	7	5
7	R:R:F66	R:R:Y42	68.5604	3.09	Yes	Yes	2	7	6
8	R:R:C85	R:R:P86	10.4322	3.77	Yes	Yes	0	9	8
9	R:R:D67	R:R:Y69	24.0346	5.75	Yes	Yes	2	9	6
10	R:R:E68	R:R:F66	99.0092	7	No	Yes	0	4	7
11	R:R:D67	R:R:R121	16.9377	11.91	Yes	Yes	2	9	6
12	R:R:L123	R:R:Y69	34.5873	21.1	Yes	Yes	2	5	6
13	R:R:L123	R:R:R121	17.2331	2.43	Yes	Yes	2	5	6
14	R:R:E68	R:R:R299	99.1018	5.82	No	No	0	4	4
15	R:R:D114	R:R:S117	40.9536	8.83	No	No	0	4	7
16	R:R:L118	R:R:S117	43.1033	3	Yes	No	0	4	7
17	R:R:L118	R:R:R121	32.7709	20.65	Yes	Yes	2	4	6
18	R:R:H212	R:R:L118	16.5492	3.86	No	Yes	2	3	4
19	R:R:H212	R:R:L123	17.2615	3.86	No	Yes	2	3	5
20	R:R:D114	R:R:S116	38.8033	5.89	No	No	0	4	5
21	R:R:S116	R:R:Y220	36.6524	7.63	No	No	0	5	3
22	R:R:G295	R:R:R299	99.2129	3	No	No	0	4	4
23	R:R:C296	R:R:G295	99.5123	1.96	Yes	No	0	9	4
24	R:R:C296	R:R:F230	100	4.19	Yes	No	4	9	5
25	R:R:F230	R:R:Q234	32.9476	4.68	No	No	4	5	7
26	R:R:I309	R:R:Q234	32.9181	4.12	No	No	4	7	7
27	R:R:F280	R:R:I309	67.1149	2.51	Yes	No	4	5	7
28	R:R:F280	R:R:I313	16.4543	3.77	Yes	No	0	5	7
29	R:R:I313	R:R:Y241	14.3849	3.63	No	Yes	0	7	8
30	R:R:V237	R:R:Y241	13.6864	2.52	No	Yes	0	6	8
31	R:R:R190	R:R:V237	13.6614	3.92	Yes	No	0	8	6
32	R:R:R190	R:R:Y152	10.9962	7.2	Yes	Yes	0	8	7
33	R:R:F230	R:R:W284	67.1479	5.01	No	Yes	4	5	8
34	R:R:I309	R:R:W284	34.3641	7.05	No	Yes	4	7	8
35	R:R:L183	R:R:W243	20.069	3.42	Yes	Yes	1	9	9
36	R:R:W243	R:R:W274	30.4886	21.56	Yes	Yes	1	9	9
37	R:R:W274	R:R:Y235	32.7545	7.72	Yes	Yes	0	9	9
38	R:R:V281	R:R:Y235	33.0761	7.57	No	Yes	0	6	9
39	R:R:L231	R:R:V281	33.013	2.98	No	No	0	5	6
40	R:R:L231	R:R:W284	32.32	2.28	No	Yes	0	5	8
41	R:R:I179	R:R:Y250	10.4429	7.25	Yes	Yes	1	8	8
42	R:R:I179	R:R:W243	10.9015	3.52	Yes	Yes	1	8	9
43	R:R:Y250	R:R:Y269	19.1422	5.96	Yes	Yes	1	8	7
44	R:R:V249	R:R:Y269	20.7598	5.05	No	Yes	0	6	7
45	R:R:L245	R:R:V249	20.923	2.98	Yes	No	0	8	6
46	R:R:L245	R:R:Y242	49.5032	2.34	Yes	Yes	0	8	6
47	R:R:F280	R:R:Y242	50.1954	6.19	Yes	Yes	4	5	6
48	R:R:L183	R:R:Y402	17.518	2.34	Yes	Yes	1	9	8
49	R:R:L349	R:R:Y250	19.2213	2.34	Yes	Yes	1	9	8
50	R:R:L349	R:R:T353	12.3376	2.95	Yes	Yes	1	9	9
51	R:R:I357	R:R:T353	14.1482	3.04	Yes	Yes	1	8	9
52	R:R:I357	R:R:N320	27.4689	5.66	Yes	No	1	8	9
53	R:R:L245	R:R:N320	27.9385	9.61	Yes	No	0	8	9
54	R:R:M204	R:R:Y220	25.8894	9.58	Yes	No	0	3	3
55	R:R:L217	R:R:M204	15.1121	2.83	Yes	Yes	6	4	3
56	R:R:F324	R:R:I357	13.4268	6.28	Yes	Yes	1	9	8
57	R:R:I330	R:R:Y252	28.2712	2.42	No	Yes	0	9	8
58	R:R:I330	R:R:L255	16.9618	2.85	No	No	1	9	8
59	R:R:L255	R:R:M340	19.7867	2.83	No	Yes	1	8	5
60	R:R:M340	R:R:V331	21.1915	6.09	Yes	Yes	1	5	8
61	R:R:V331	W:W:?2	24.0076	5.02	Yes	Yes	1	8	0
62	R:R:I328	W:W:?2	12.263	3.85	No	Yes	1	7	0
63	R:R:F324	R:R:I328	12.2254	5.02	Yes	No	1	9	7
64	R:R:I330	R:R:K334	16.9618	5.82	No	No	1	9	9
65	R:R:K334	R:R:M340	19.7867	11.52	No	Yes	1	9	5
66	R:R:F347	R:R:M340	21.2044	2.49	Yes	Yes	1	7	5
67	R:R:F347	W:W:?2	25.4195	7.39	Yes	Yes	1	7	0
68	R:R:L349	W:W:?2	39.5715	2.8	Yes	Yes	1	9	0
69	R:R:R326	R:R:Y252	11.31	1.03	No	Yes	0	8	8
70	R:R:Y69	R:R:Y88	39.4524	4.96	Yes	Yes	2	6	5
71	R:R:P86	R:R:Y69	19.9333	8.34	Yes	Yes	2	8	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:H180	R:R:R176	3.39	1	Yes	Yes	9	9	2	2
R:R:R176	R:R:Y250	8.23	1	Yes	Yes	9	8	2	2
R:R:L349	R:R:R176	7.29	1	Yes	Yes	9	9	1	2
R:R:N406	R:R:R176	6.03	1	Yes	Yes	9	9	1	2
R:R:E408	R:R:R176	3.49	1	Yes	Yes	9	9	2	2
R:R:H180	R:R:L349	7.71	1	Yes	Yes	9	9	2	1
R:R:H180	R:R:Y402	15.24	1	Yes	Yes	9	8	2	2
R:R:L349	R:R:Y250	2.34	1	Yes	Yes	9	8	1	2
R:R:L251	R:R:L349	4.15	1	Yes	Yes	9	9	2	1
R:R:L251	R:R:T353	7.37	1	Yes	Yes	9	9	2	2
R:R:F324	R:R:I328	5.02	1	Yes	No	9	7	2	1
R:R:F324	R:R:L354	7.31	1	Yes	No	9	8	2	2
R:R:I328	R:R:L354	4.28	1	No	No	7	8	1	2
R:R:I328	W:W:?2	3.85	1	No	Yes	7	0	1	0
R:R:L335	R:R:V331	2.98	1	No	Yes	8	8	2	1
R:R:M340	R:R:V331	6.09	1	Yes	Yes	5	8	2	1
R:R:F347	R:R:V331	2.62	1	Yes	Yes	7	8	1	1
R:R:V331	W:W:?2	5.02	1	Yes	Yes	8	0	1	0
R:R:K342	R:R:L335	4.23	1	No	No	5	8	2	2
R:R:F347	R:R:L335	2.44	1	Yes	No	7	8	1	2
R:R:F347	R:R:M340	2.49	1	Yes	Yes	7	5	1	2
R:R:F347	R:R:K342	14.89	1	Yes	No	7	5	1	2
R:R:F347	R:R:K351	8.69	1	Yes	No	7	8	1	1
R:R:F347	W:W:?2	7.39	1	Yes	Yes	7	0	1	0
R:R:K351	R:R:R348	8.66	1	No	No	8	8	1	1
R:R:N407	R:R:R348	12.05	1	Yes	No	6	8	1	1
R:R:R348	W:W:?2	4.1	1	No	Yes	8	0	1	0
R:R:L349	R:R:T353	2.95	1	Yes	Yes	9	9	1	2
R:R:L349	R:R:Y402	3.52	1	Yes	Yes	9	8	1	2
R:R:L349	W:W:?2	2.8	1	Yes	Yes	9	0	1	0
R:R:K351	W:W:?2	35.19	1	No	Yes	8	0	1	0
R:R:L401	R:R:S352	4.5	1	Yes	No	8	9	1	1
R:R:S352	R:R:Y402	10.17	1	No	Yes	9	8	1	2
R:R:S352	W:W:?2	6.08	1	No	Yes	9	0	1	0
R:R:T353	R:R:Y402	7.49	1	Yes	Yes	9	8	2	2
R:R:L401	R:R:T355	2.95	1	Yes	No	8	8	1	1
R:R:T355	W:W:?2	10.94	1	No	Yes	8	0	1	0
R:R:L356	R:R:L401	4.15	1	No	Yes	9	8	2	1
R:R:L356	R:R:Y402	4.69	1	No	Yes	9	8	2	2
R:R:L401	W:W:?2	2.8	1	Yes	Yes	8	0	1	0
R:R:V405	W:W:?2	12.06	0	No	Yes	6	0	1	0
R:R:E408	R:R:N406	7.89	1	Yes	Yes	9	9	2	1
R:R:N406	R:R:V409	4.43	1	Yes	No	9	9	1	2
R:R:N406	W:W:?2	12.97	1	Yes	Yes	9	0	1	0
R:R:E408	R:R:N407	2.63	1	Yes	Yes	9	6	2	1
R:R:N407	W:W:?2	5.56	1	Yes	Yes	6	0	1	0
R:R:V332	W:W:?2	2.01	0	No	Yes	6	0	1	0
R:R:S333	R:R:V332	1.62	0	No	No	7	6	2	1
R:R:L401	R:R:M397	1.41	1	Yes	No	8	5	1	2
R:R:N407	R:R:Q410	1.32	1	Yes	No	6	7	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
76.92	Single	5VEW	PF-06372222	5VEW-GLP-1-PF-06372222
69.23	Single	6KJV	PubChem 68178630	6KJV-GLP-1-PubChem 68178630
66.67	Single	5XF1	NNC0640	5XF1-Glucagon-NNC0640
60.00	Single	5XEZ	NNC0640	5XEZ-Glucagon-NNC0640
50.00	Single	5VEX	NNC0640	5VEX-GLP-1-NNC0640
50.00	Single	6KK7	PubChem 68178630	6KK7-GLP-1-PubChem 68178630
31.25	Single	7CA3	rac-BHFF	7CA3-GABA_B1, GABA_B2-rac-BHFF
29.41	Single	7C7Q	PubChem 7023848	7C7Q-GABA_B1, GABA_B2-Baclofen-PubChem 7023848
28.57	Single	8TB7	PubChem 168510218	8TB7-GPR61-PubChem 168510218
26.67	Single	7EB2	rac-BHFF	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
26.67	Consensus	class-c_on	Other Ligand	gabab_on mglu_on
26.67	Consensus	gabab_on	Other Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
26.67	Consensus	gi_class-c	Other Ligand	gi_mglu gi_gaba
25.00	Consensus	gi_gaba	Other Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
21.74	Single	8JD3	HZR; PEF	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
21.05	Single	5X7D	PubChem 129318963	5X7D-β₂-(S)-Carazolol-PubChem 129318963
19.23	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
17.39	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
16.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
15.79	Single	6KK1	PubChem 68178630	6KK1-GLP-1-PubChem 68178630
15.38	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
15.00	Single	7EJX	(1R;2R)-2-PCCA	7EJX-GPR88-(1R;2R)-2-PCCA-Gi1/&β;1/&γ;2
14.29	Single	8JPF	PubChem 118610427	8JPF-NTS₁-Neurotensin-PubChem 118610427
13.33	Single	4PXF	Octyl Beta-D-Glucopyranoside	4PXF-Rhodopsin-Octyl Beta-D-Glucopyranoside-Arrestin1_Finger_loop
13.33	Single	7DUQ	PubChem 156022738	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
10.53	Single	5T1A	PubChem 68764898; PubChem 12093170	5T1A-CCR2-PubChem 68764898; PubChem 12093170
10.00	Consensus	nts1_on_allo	Other Ligand	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
9.09	Single	8JR9	PCO371	8JR9-PTH1-PCO371-chim(NtGi1-Gs)/&β;1/&γ;2
8.70	Single	6LFL	PubChem 153466996	6LFL-CXCR2-PubChem 153466996
8.70	Single	8GW8	KHF	8GW8-PTH1-KHF-Gs/&β;1/&γ;2
8.70	Single	8JPC	PubChem 118610427; GDP; Mg	8JPC-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
8.33	Single	8JPB	PubChem 118610427; GDP; Mg	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
8.00	Single	5LWE	Vercirnon	5LWE-CCR9-Vercirnon
8.00	Consensus	ccr9_off_allo	Other Ligand	5LWE-CCR9-Vercirnon
7.69	Single	7DUR	PubChem 156022738	7DUR-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
7.14	Single	7E14	PubChem 156022738	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
7.14	Single	7EVM	PubChem 156022738	7EVM-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
6.25	Single	6UO8	GS39783	6UO8-GABA_B1, GABA_B2-SKF97541-GS39783
6.06	Single	3VG9	Antibody	3VG9-A_2A-ZM241385-Antibody
5.88	Consensus	ccr2_off_allo	Other Ligand	5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
5.71	Single	3VGA	Antibody	3VGA-A_2A-ZM241385-Antibody
5.26	Consensus	gip_on_allo	Other Ligand	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Single	8HNN	SCH546738	8HNN-CXCR3-SCH546738
4.17	Consensus	ffa3_on_allo	Other Ligand	8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
4.00	Single	8J20	AR420626	8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2

PDB Summary
PDB	6LN2
Class	B1
SubFamily	Peptide
Type	Glucagon
SubType	GLP-1
Species	Homo sapiens
Ligand	-
Other Ligand(s)	PubChem 68178630
Protein Partners	-
PDB Resolution	3.2
Date	2020-03-18
D.O.I.	10.1038/s41467-020-14934-5

Net Summary
I_min	2.26
Number of Linked Nodes	357
Number of Links	472
Number of Hubs	85
Number of Links mediated by Hubs	315
Number of Communities	11
Number of Nodes involved in Communities	139
Number of Links involved in Communities	216

Path Summary
Number Of Nodes in MetaPath	72
Number Of Links MetaPath	71
Number of Shortest Paths	450036
Length Of Smallest Path	3
Average Path Length	22.5474
Length of Longest Path	38
Minimum Path Strength	1.21
Average Path Strength	5.88871
Maximum Path Strength	24.08
Minimum Path Correlation	0.7
Average Path Correlation	0.944482
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	36.5547
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	55.7389
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	97Y
PDB Residues	W:W:?2
Environment Details	Open EMBL-EBI Page
Code	97Y
Name	N-{4-[(R)-(3,3-dimethylcyclobutyl)({6-[4-(trifluoromethyl)-1H-imidazol-1-yl]pyridin-3-yl}amino)methyl]benzene-1-carbonyl}-beta-alanine
Synonyms
Identifier	3-[[4-[(~{R})-(3,3-dimethylcyclobutyl)-[[6-[4-(trifluoromethyl)imidazol-1-yl]pyridin-3-yl]amino]methyl]phenyl]carbonylamino]propanoic acid
Formula	C26 H28 F3 N5 O3
Molecular Weight	515.527
SMILES	CC1(CC(C1)[C@H](c2ccc(cc2)C(=O)NCCC(=O)O)Nc3ccc(nc3)n4cc(nc4)C(F)(F)F)C
PubChem	68178630
Formal Charge	0
Total Atoms	65
Total Chiral Atoms	1
Total Bonds	68
Total Aromatic Bonds	17


Code	NAG
PDB Residues	H:H:?1
Environment Details	Open EMBL-EBI Page
Code	NAG
Name	N-Acetylglucosamine
Synonyms	N-Acetyl-D-glucosamine
Identifier	N-[(2R,3R,4R,5S,6R)-6-(hydroxymethyl)-2,4,5-tris(oxidanyl)oxan-3-yl]ethanamide
Formula	C8 H15 N O6
Molecular Weight	221.208
SMILES	CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O
PubChem	24139
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	5
Total Bonds	30
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P43220
Sequence	>6LN2_Chain_R T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S S P E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F R H L H C T R N Y I H L N L F A S F I L R A L C V F F K D A A L K W M Y S T A A Q Q H Q W D G L L S Y Q D S L A C R L V F L L C Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F E Q W I F R L Y V A I G W G V P L L F V V P W G I V K Y L Y E D E G C W T R N S N M N Y W L I I R L P I L F A C I V N F L I F V R V I C I V V S K L K A N L M C K T D I A F R L A K S T L T L I P L L C T H E V I F A F V M D E H A R G T L R F I K L F T D L S F T S F Q G L M V A I L Y C F V N N E V Q L E F R K S W E R W R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5NX2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1 (Truncated)	-	-	3.7	2017-06-14	10.1038/nature22800
	5VAI	B1	Peptide	Glucagon	GLP-1	Oryctolagus cuniculus	GLP-1	-	Gs/&β;1/&γ;2	4.1	2017-05-24	10.1038/nature22394
	5VEW	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PF-06372222	-	2.7	2017-05-24	10.1038/nature22378
	5VEX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	NNC0640	-	3	2017-05-17	10.1038/nature22378
	6B3J	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-P5	-	Gs/&β;1/&γ;2	3.3	2018-02-21	10.1038/nature25773
	6KJV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	2.8	2019-11-13	10.1107/S2052252519013496
	6KK1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	2.8	2019-11-13	10.1107/S2052252519013496
	6KK7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	3.1	2019-11-13	10.1107/S2052252519013496
	6LN2	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 68178630	-	3.2	2020-03-18	10.1038/s41467-020-14934-5
	6ORV	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	TT-OAD2	Gs/&β;1/&γ;2	3	2020-01-08	10.1038/s41586-019-1902-z
	6VCB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	LSN3160440	Gs/&β;1/&γ;2	3.3	2020-07-22	10.1038/s41589-020-0589-7
	6X18	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	-	Gs/&β;1/&γ;2	2.1	2020-09-09	10.1016/j.molcel.2020.09.020
	6X19	B1	Peptide	Glucagon	GLP-1	Homo sapiens	CHU-128	-	Gs/&β;1/&γ;2	2.1	2020-09-09	10.1016/j.molcel.2020.09.020
	6X1A	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/&β;1/&γ;2	2.5	2020-09-09	10.1016/j.molcel.2020.09.020
	6XOX	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	-	chim(NtGi1-Gs)/&β;1/&γ;2	3.1	2020-11-18	10.1073/pnas.2014879117
	7C2E	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 149050799	-	Gs/&β;1/&γ;2	4.2	2020-08-26	10.1038/s41422-020-0384-8
	7DUQ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	GLP-1	PubChem 156022738	Gs/&β;1/&γ;2	2.5	2021-07-14	10.1038/s41467-021-24058-z
	7DUR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/&β;1/&γ;2	3.3	2021-08-11	10.1038/s41467-021-24058-z
	7E14	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Orforglipron	PubChem 156022738	Gs/&β;1/&γ;2	2.9	2021-07-07	10.1038/s41467-021-24058-z
	7EVM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	PubChem 156022738	Gs/&β;1/&γ;2	2.5	2021-08-11	10.1038/s41467-021-24058-z
	7FIM	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	Gs/&β;1/&γ;2	3.4	2022-03-02	10.1038/s41467-022-28683-0
	7KI0	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Semaglutide	-	Gs/&β;1/&γ;2	2.5	2021-08-04	10.1016/j.celrep.2021.109374
	7KI1	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Taspoglutide	-	Gs/&β;1/&γ;2	2.5	2021-08-04	10.1016/j.celrep.2021.109374
	7LCI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	Gs/&β;1/&γ;2	2.9	2021-01-20	10.1016/j.str.2021.04.008
	7LCJ	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	2.82	2021-01-20	10.1016/j.str.2021.04.008
	7LCK	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Danuglipron	-	-	3.24	2021-01-20	10.1016/j.str.2021.04.008
	7LLL	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Exendin-4	-	Gs/&β;1/&γ;2	3.7	2022-01-12	10.1038/s41467-021-27760-0
	7LLY	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Oxyntomodulin	-	Gs/&β;1/&γ;2	3.3	2022-01-12	10.1038/s41467-021-27760-0
	7RG9	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	chim(NtGi1-Gs)/&β;1/&γ;2	3.2	2022-04-13	10.1073/pnas.2116506119
	7RGP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Tirzepatide	-	chim(NtGi1-Gs)/&β;1/&γ;2	2.9	2022-04-13	10.1073/pnas.2116506119
	7RTB	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-19	-	Gs/&β;1/&γ;2	2.14	2021-10-06	10.1016/j.bbrc.2021.09.016
	7S15	B1	Peptide	Glucagon	GLP-1	Homo sapiens	PubChem 134611223	-	-	3.8	2022-06-08	10.1021/acs.jmedchem.1c01856
	7S1M	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Ex4-D-Ala	-	Gs/&β;1/&γ;2	2.41	2022-01-05	10.1038/s41589-021-00945-w
	7S3I	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/&β;1/&γ;2	2.51	2022-01-05	10.1038/s41589-021-00945-w
	7VBH	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-20	-	Gs/&β;1/&γ;2	3	2022-04-06	10.1038/s41467-022-28683-0
	7VBI	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Non-Acylated Tirzepatide	-	Gs/&β;1/&γ;2	3	2022-03-02	10.1038/s41467-022-28683-0
	7X8R	B1	Peptide	Glucagon	GLP-1	Homo sapiens	BOC5	-	Gs/&β;1/&γ;2	2.61	2022-06-29	10.1073/pnas.2200155119
	7X8S	B1	Peptide	Glucagon	GLP-1	Homo sapiens	WB4-24	-	Gs/&β;1/&γ;2	3.09	2022-06-29	10.1073/pnas.2200155119
	8JIP	B1	Peptide	Glucagon	GLP-1	Homo sapiens	MEDI0382	-	chim(NtGi1-Gs)/&β;1/&γ;2	2.85	2023-09-06	10.1073/pnas.2303696120
	8JIR	B1	Peptide	Glucagon	GLP-1	Homo sapiens	SAR425899	-	chim(NtGi1-Gs)/&β;1/&γ;2	2.57	2023-09-06	10.1073/pnas.2303696120
	8JIS	B1	Peptide	Glucagon	GLP-1	Homo sapiens	Peptide-15	-	chim(NtGi1-Gs)/&β;1/&γ;2	2.46	2023-11-08	10.1073/pnas.2303696120
	8WG7	B1	Peptide	Glucagon	GLP-1	Homo sapiens	-	-	Gs/&β;1/&γ;2	2.54	2024-03-06	10.1038/s41421-024-00649-0

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