psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F47	R:R:V44	3.93	No	No	0	4	5
2	R:R:F48	R:R:V44	5.24	No	No	0	4	5
3	R:R:L46	R:R:M98	4.24	No	Yes	0	5	6
4	R:R:M49	R:R:M98	4.33	No	Yes	0	6	6
5	R:R:M49	R:R:W328	20.94	No	Yes	0	6	5
6	R:R:L50	R:R:M98	4.24	No	Yes	0	3	6
7	R:R:F332	R:R:L52	4.87	No	No	0	4	6
8	R:R:D53	R:R:M94	11.09	No	No	3	7	7
9	R:R:D53	R:R:P95	3.22	No	No	3	7	9
10	R:R:T335	R:R:T55	6.28	No	No	0	6	5
11	R:R:A56	R:R:T335	5.03	No	No	0	7	6
12	R:R:D86	R:R:N60	14.81	No	Yes	2	9	9
13	R:R:L87	R:R:N60	5.49	No	Yes	0	7	9
14	R:R:N60	R:R:P338	6.52	Yes	No	2	9	9
15	R:R:C83	R:R:V63	3.42	No	No	0	9	9
16	R:R:F80	R:R:I67	8.79	No	No	0	5	7
17	R:R:R74	R:R:T70	21.99	No	No	0	8	6
18	R:R:L73	R:R:P71	3.28	No	No	0	8	6
19	R:R:F76	R:R:L73	3.65	Yes	No	0	9	8
20	R:R:I348	R:R:L73	4.28	Yes	No	0	8	8
21	R:R:F76	R:R:K75	4.96	Yes	No	0	9	7
22	R:R:K75	R:R:Y143	3.58	No	No	0	7	8
23	R:R:F76	R:R:V79	3.93	Yes	No	0	9	8
24	R:R:F76	R:R:R140	5.34	Yes	No	0	9	9
25	R:R:F76	R:R:N345	3.62	Yes	No	0	9	9
26	R:R:E139	R:R:F78	4.66	No	No	0	9	8
27	R:R:I136	R:R:V79	4.61	No	No	0	9	8
28	R:R:F80	R:R:L84	7.31	No	No	0	5	5
29	R:R:H81	R:R:S132	8.37	No	No	0	9	8
30	R:R:H81	R:R:L163	9	No	No	0	9	7
31	R:R:H81	R:R:W167	5.29	No	No	0	9	9
32	R:R:I136	R:R:L82	4.28	No	No	0	9	9
33	R:R:L82	R:R:Y341	3.52	No	Yes	0	9	9
34	R:R:L128	R:R:V85	7.45	No	No	0	7	8
35	R:R:D86	R:R:F334	5.97	No	No	0	9	9
36	R:R:D86	R:R:P338	4.83	No	No	2	9	9
37	R:R:A89	R:R:F125	4.16	No	Yes	0	7	7
38	R:R:F125	R:R:T92	3.89	Yes	No	0	7	5
39	R:R:L93	R:R:Y118	4.69	No	Yes	4	8	6
40	R:R:L93	R:R:Y331	7.03	No	Yes	4	8	8
41	R:R:M94	R:R:P95	3.35	No	No	3	7	9
42	R:R:M94	R:R:W328	3.49	No	Yes	0	7	5
43	R:R:L96	R:R:Y118	8.21	No	Yes	0	4	6
44	R:R:A97	R:R:Y118	5.34	No	Yes	0	7	6
45	R:R:A97	R:R:W328	3.89	No	Yes	0	7	5
46	R:R:E112	R:R:R116	4.65	No	No	0	4	7
47	R:R:L117	R:R:L121	5.54	No	No	0	3	5
48	R:R:Y118	R:R:Y331	6.95	Yes	Yes	4	6	8
49	R:R:F120	R:R:L121	3.65	No	No	0	6	5
50	R:R:A174	R:R:F120	4.16	No	No	0	8	6
51	R:R:S122	R:R:Y331	6.36	No	Yes	0	8	8
52	R:R:A174	R:R:V123	3.39	No	No	0	8	7
53	R:R:C124	R:R:F125	4.19	No	Yes	0	5	7
54	R:R:A170	R:R:S127	3.42	No	No	0	8	7
55	R:R:S127	R:R:Y216	8.9	No	Yes	0	7	6
56	R:R:L128	R:R:W167	9.11	No	No	0	7	9
57	R:R:A170	R:R:L128	3.15	No	No	0	8	7
58	R:R:I130	R:R:Y216	8.46	Yes	Yes	0	8	6
59	R:R:I130	R:R:P220	3.39	Yes	Yes	1	8	9
60	R:R:F296	R:R:I130	3.77	Yes	Yes	1	9	8
61	R:R:I130	R:R:W300	10.57	Yes	No	1	8	8
62	R:R:L131	R:R:V166	8.94	No	No	0	6	6
63	R:R:L131	R:R:Y216	4.69	No	Yes	0	6	6
64	R:R:N337	R:R:V133	4.43	No	No	1	9	8
65	R:R:V133	R:R:Y341	8.83	No	Yes	1	8	9
66	R:R:P220	R:R:S134	3.56	Yes	No	0	9	6
67	R:R:I224	R:R:N137	5.66	No	No	1	8	8
68	R:R:N137	R:R:Y341	3.49	No	Yes	1	8	9
69	R:R:N137	W:W:?1	10.24	No	Yes	1	8	0
70	R:R:V138	R:R:Y142	6.31	No	No	0	6	5
71	R:R:L223	R:R:V138	4.47	No	No	0	6	6
72	R:R:E139	R:R:R140	8.14	No	No	0	9	9
73	R:R:E139	R:R:Y150	5.61	No	Yes	0	9	7
74	R:R:R140	W:W:?1	14.35	No	Yes	0	9	0
75	R:R:Y141	R:R:Y142	5.96	Yes	No	0	8	5
76	R:R:V145	R:R:Y141	11.36	No	Yes	0	6	8
77	R:R:V227	R:R:Y141	7.57	No	Yes	0	5	8
78	R:R:S230	R:R:Y141	8.9	No	Yes	0	5	8
79	R:R:R153	R:R:Y142	8.23	Yes	No	0	5	5
80	R:R:Y143	R:R:Y150	13.9	No	Yes	0	8	7
81	R:R:H146	R:R:V145	8.3	No	No	0	6	6
82	R:R:R153	R:R:Y150	5.14	Yes	Yes	0	5	7
83	R:R:L158	R:R:R153	4.86	No	Yes	0	6	5
84	R:R:F208	R:R:M173	6.22	No	No	0	8	6
85	R:R:F212	R:R:M173	3.73	No	No	0	6	6
86	R:R:P177	R:R:V176	7.07	No	No	5	6	6
87	R:R:F208	R:R:V176	9.18	No	No	5	8	6
88	R:R:F208	R:R:P177	5.78	No	No	5	8	6
89	R:R:L179	R:R:V178	4.47	No	No	0	4	6
90	R:R:L308	R:R:V210	4.47	No	No	0	5	5
91	R:R:F212	R:R:Y216	18.57	No	Yes	0	6	6
92	R:R:F212	R:R:F304	5.36	No	Yes	0	6	7
93	R:R:A213	R:R:F304	4.16	No	Yes	0	6	7
94	R:R:F217	R:R:F304	12.86	No	Yes	0	8	7
95	R:R:L219	R:R:P220	4.93	No	Yes	0	5	9
96	R:R:F296	R:R:P220	4.33	Yes	Yes	1	9	9
97	R:R:I224	W:W:?1	5.32	No	Yes	1	8	0
98	R:R:V227	W:W:?1	4.63	No	Yes	0	5	0
99	R:R:L289	R:R:Y228	14.07	No	No	0	8	9
100	R:R:Y228	W:W:?1	3.64	No	Yes	0	9	0
101	R:R:A285	R:R:M231	3.22	No	No	0	8	9
102	R:R:M231	W:W:?1	6.15	No	Yes	0	9	0
103	R:R:V288	W:W:?1	25	No	Yes	0	9	0
104	R:R:G293	R:R:V292	3.68	No	No	0	7	8
105	R:R:V292	W:W:?1	6.48	No	Yes	0	8	0
106	R:R:F296	R:R:Q295	3.51	Yes	Yes	1	9	6
107	R:R:N337	R:R:Q295	3.96	No	Yes	1	9	6
108	R:R:F340	R:R:Q295	4.68	No	Yes	0	8	6
109	R:R:Q295	R:R:Y341	6.76	Yes	Yes	1	6	9
110	R:R:F296	R:R:W300	17.04	Yes	No	1	9	8
111	R:R:L297	R:R:L301	4.15	No	No	0	5	6
112	R:R:C299	R:R:I329	3.27	Yes	No	0	8	7
113	R:R:C299	R:R:G330	3.92	Yes	No	0	8	7
114	R:R:C299	R:R:C333	7.28	Yes	No	0	8	9
115	R:R:L301	R:R:P302	3.28	No	No	0	6	9
116	R:R:F304	R:R:Y303	7.22	Yes	No	0	7	7
117	R:R:H307	R:R:Y303	16.33	No	No	0	6	7
118	R:R:T327	R:R:Y303	8.74	No	No	0	6	7
119	R:R:F306	R:R:V310	3.93	Yes	No	0	5	4
120	R:R:F306	R:R:V322	5.24	Yes	No	0	5	5
121	R:R:E323	R:R:F306	3.5	No	Yes	0	4	5
122	R:R:F306	R:R:V326	9.18	Yes	No	0	5	5
123	R:R:Q321	R:R:V322	4.3	No	No	0	2	5
124	R:R:S324	R:R:W328	4.94	No	Yes	0	5	5
125	R:R:T327	R:R:Y331	12.48	No	Yes	0	6	8
126	R:R:W328	R:R:Y331	4.82	Yes	Yes	0	5	8
127	R:R:C333	R:R:S336	5.16	No	No	0	9	5
128	R:R:F340	R:R:S336	5.28	No	No	0	8	5
129	R:R:N337	R:R:Y341	3.49	No	Yes	1	9	9
130	R:R:Y341	W:W:?1	5.1	Yes	Yes	1	9	0
131	R:R:G342	R:R:I348	3.53	No	Yes	0	7	8
132	R:R:C343	R:R:L344	3.17	No	No	0	5	7
133	R:R:L344	W:W:?1	11.18	No	Yes	0	7	0
134	R:R:I348	R:R:N345	8.5	Yes	No	0	8	9
135	R:R:N345	W:W:?1	8.53	No	Yes	0	9	0
136	R:R:L158	R:R:V162	2.98	No	No	0	6	6
137	R:R:L163	R:R:V159	2.98	No	No	0	7	7
138	R:R:L215	R:R:V211	2.98	No	No	0	5	3
139	R:R:L51	R:R:T55	2.95	No	No	0	4	5
140	R:R:L121	R:R:T92	2.95	No	No	0	5	5
141	R:R:A291	W:W:?1	2.94	No	Yes	0	7	0
142	R:R:E323	R:R:S324	2.87	No	No	0	4	5
143	R:R:A135	R:R:F78	2.77	No	No	0	7	8
144	R:R:A89	R:R:F334	2.77	No	No	0	7	9
145	R:R:A129	R:R:F334	2.77	No	No	0	9	9
146	R:R:L221	R:R:L225	2.77	No	No	0	6	4
147	R:R:F120	R:R:S175	2.64	No	No	0	6	5
148	R:R:R153	R:R:V152	2.62	Yes	No	0	5	5
149	R:R:F80	R:R:M64	2.49	No	No	0	5	7
150	R:R:V126	R:R:W300	2.45	No	No	0	7	8
151	R:R:F125	R:R:L88	2.44	Yes	No	0	7	7
152	R:R:L215	R:R:Y216	2.34	No	Yes	0	5	6
153	R:R:R346	W:W:?1	2.27	No	Yes	0	7	0
154	R:R:E151	R:R:Y150	2.24	No	Yes	0	5	7
155	R:R:G293	R:R:G294	2.11	No	No	0	7	5
156	R:R:A58	R:R:G59	1.95	No	No	0	3	9
157	R:R:C205	R:R:P177	1.88	No	No	0	6	6
158	R:R:G165	R:R:V164	1.84	No	No	0	1	2
159	R:R:G165	R:R:V168	1.84	No	No	0	1	3
160	R:R:A170	R:R:C124	1.81	No	No	0	8	5
161	R:R:A56	R:R:A90	1.79	No	No	2	7	7
162	R:R:P338	R:R:V63	1.77	No	No	0	9	9
163	R:R:P302	R:R:V326	1.77	No	No	0	9	5
164	R:R:P71	R:R:T70	1.75	No	No	0	6	6
165	R:R:C205	R:R:V209	1.71	No	No	0	6	6
166	R:R:A90	R:R:V57	1.7	No	No	0	7	6
167	R:R:A311	R:R:V209	1.7	No	No	0	6	6
168	R:R:K69	R:R:P71	1.67	No	No	0	6	6
169	R:R:A65	R:R:M64	1.61	No	No	0	4	7
170	R:R:V159	R:R:V77	1.6	No	No	0	7	4
171	R:R:V144	R:R:V145	1.6	No	No	0	8	6
172	R:R:V209	R:R:V210	1.6	No	No	0	6	5
173	R:R:V210	R:R:V214	1.6	No	No	0	5	3
174	R:R:C124	R:R:L171	1.59	No	No	0	5	3
175	R:R:C299	R:R:L298	1.59	Yes	No	0	8	4
176	R:R:A45	R:R:L46	1.58	No	No	0	5	5
177	R:R:A160	R:R:L156	1.58	No	No	0	3	4
178	R:R:A56	R:R:N60	1.56	No	Yes	2	7	9
179	R:R:A90	R:R:N60	1.56	No	Yes	2	7	9
180	R:R:I67	R:R:V66	1.54	No	No	0	7	7
181	R:R:I348	R:R:V66	1.54	Yes	No	0	8	7
182	R:R:I67	R:R:V79	1.54	No	No	0	7	8
183	R:R:I329	R:R:V325	1.54	No	No	0	7	4
184	R:R:H146	R:R:P147	1.53	No	No	0	6	9
185	R:R:L301	R:R:S305	1.5	No	No	0	6	5
186	R:R:L119	R:R:V123	1.49	No	No	0	5	7
187	R:R:L218	R:R:V214	1.49	No	No	0	5	3
188	R:R:L52	R:R:T55	1.47	No	No	0	6	5
189	R:R:L158	R:R:T155	1.47	No	No	0	6	8
190	R:R:I224	R:R:L225	1.43	No	No	0	8	4
191	R:R:L99	R:R:M98	1.41	No	Yes	0	5	6
192	R:R:C343	R:R:F339	1.4	No	No	0	5	6
193	R:R:D53	R:R:L54	1.36	No	No	0	7	4
194	R:R:K75	R:R:Q347	1.36	No	No	0	7	7
195	R:R:L207	R:R:Q206	1.33	No	No	0	3	4
196	R:R:R149	R:R:V152	1.31	No	No	0	5	5
197	R:R:L119	R:R:R116	1.21	No	No	0	5	7
198	R:R:V287	W:W:?1	0.93	No	Yes	0	7	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:N60	5.988	5	2	9
2	R:R:F76	4.3	5	0	9
3	R:R:M98	3.555	4	0	6
4	R:R:Y118	6.2975	4	4	6
5	R:R:F125	3.67	4	0	7
6	R:R:I130	6.5475	4	1	8
7	R:R:Y141	8.4475	4	0	8
8	R:R:Y150	6.7225	4	0	7
9	R:R:R153	5.2125	4	0	5
10	R:R:Y216	8.592	5	0	6
11	R:R:P220	4.0525	4	1	9
12	R:R:Q295	4.7275	4	1	6
13	R:R:F296	7.1625	4	1	9
14	R:R:C299	4.015	4	0	8
15	R:R:F304	7.4	4	0	7
16	R:R:F306	5.4625	4	0	5
17	R:R:W328	7.616	5	0	5
18	R:R:Y331	7.528	5	4	8
19	R:R:Y341	5.19833	6	1	9
20	R:R:I348	4.4625	4	0	8
21	W:W:?1	7.62571	14	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:M49	R:R:W328	11.5339	20.94	No	Yes	0	6	5
2	R:R:A56	R:R:T335	10.3581	5.03	No	No	0	7	6
3	R:R:A56	R:R:N60	12.2394	1.56	No	Yes	2	7	9
4	R:R:D86	R:R:N60	19.8717	14.81	No	Yes	2	9	9
5	R:R:D86	R:R:F334	27.675	5.97	No	No	0	9	9
6	R:R:A89	R:R:F334	31.2881	2.77	No	No	0	7	9
7	R:R:A89	R:R:F125	33.0625	4.16	No	Yes	0	7	7
8	R:R:C124	R:R:F125	51.1384	4.19	No	Yes	0	5	7
9	R:R:A170	R:R:C124	54.1101	1.81	No	No	0	8	5
10	R:R:A170	R:R:S127	66.4244	3.42	No	No	0	8	7
11	R:R:S127	R:R:Y216	67.5254	8.9	No	Yes	0	7	6
12	R:R:F212	R:R:Y216	71.6195	18.57	No	Yes	0	6	6
13	R:R:F212	R:R:F304	57.2956	5.36	No	Yes	0	6	7
14	R:R:F304	R:R:Y303	53.3298	7.22	Yes	No	0	7	7
15	R:R:T327	R:R:Y303	50.2833	8.74	No	No	0	6	7
16	R:R:T327	R:R:Y331	49.0967	12.48	No	Yes	0	6	8
17	R:R:W328	R:R:Y331	41.3683	4.82	Yes	Yes	0	5	8
18	R:R:F80	R:R:I67	10.5184	8.79	No	No	0	5	7
19	R:R:I67	R:R:V79	10.9888	1.54	No	No	0	7	8
20	R:R:Q295	R:R:Y341	96.5045	6.76	Yes	Yes	1	6	9
21	R:R:F296	R:R:Q295	99.861	3.51	Yes	Yes	1	9	6
22	R:R:F296	R:R:I130	95.1256	3.77	Yes	Yes	1	9	8
23	R:R:I130	R:R:Y216	100	8.46	Yes	Yes	0	8	6
24	R:R:Y341	W:W:?1	83.9123	5.1	Yes	Yes	1	9	0
25	R:R:R140	W:W:?1	31.9829	14.35	No	Yes	0	9	0
26	R:R:F76	R:R:R140	17.2742	5.34	Yes	No	0	9	9
27	R:R:F76	R:R:L73	17.9583	3.65	Yes	No	0	9	8
28	R:R:L73	R:R:P71	20.171	3.28	No	No	0	8	6
29	R:R:P71	R:R:T70	10.1229	1.75	No	No	0	6	6
30	R:R:N345	W:W:?1	29.9947	8.53	No	Yes	0	9	0
31	R:R:F76	R:R:N345	15.4784	3.62	Yes	No	0	9	9
32	R:R:I348	R:R:N345	15.0401	8.5	Yes	No	0	8	9
33	R:R:F76	R:R:K75	10.8071	4.96	Yes	No	0	9	7
34	R:R:E139	R:R:R140	19.4762	8.14	No	No	0	9	9
35	R:R:E139	R:R:Y150	15.3928	5.61	No	Yes	0	9	7
36	R:R:H81	R:R:W167	10.3474	5.29	No	No	0	9	9
37	R:R:L128	R:R:W167	12.3677	9.11	No	No	0	7	9
38	R:R:A170	R:R:L128	16.3228	3.15	No	No	0	8	7
39	R:R:F125	R:R:T92	18.5997	3.89	Yes	No	0	7	5
40	R:R:F120	R:R:L121	13.8963	3.65	No	No	0	6	5
41	R:R:L121	R:R:T92	17.0497	2.95	No	No	0	5	5
42	R:R:V227	W:W:?1	26.2854	4.63	No	Yes	0	5	0
43	R:R:V227	R:R:Y141	25.024	7.57	No	Yes	0	5	8
44	R:R:Y141	R:R:Y142	14.9653	5.96	Yes	No	0	8	5
45	R:R:R153	R:R:Y150	13.458	5.14	Yes	Yes	0	5	7
46	R:R:R153	R:R:Y142	10.3902	8.23	Yes	No	0	5	5
47	R:R:L158	R:R:R153	10.7643	4.86	No	Yes	0	6	5
48	R:R:F208	R:R:M173	19.4869	6.22	No	No	0	8	6
49	R:R:F212	R:R:M173	20.9727	3.73	No	No	0	6	6
50	R:R:F208	R:R:P177	15.5425	5.78	No	No	5	8	6
51	R:R:C205	R:R:V209	11.6729	1.71	No	No	0	6	6
52	R:R:C205	R:R:P177	13.6505	1.88	No	No	0	6	6
53	R:R:F340	R:R:Q295	15.5959	4.68	No	Yes	0	8	6
54	R:R:F306	R:R:V326	10.3795	9.18	Yes	No	0	5	5
55	R:R:E323	R:R:F306	18.2362	3.5	No	Yes	0	4	5
56	R:R:E323	R:R:S324	20.1924	2.87	No	No	0	4	5
57	R:R:S324	R:R:W328	22.1058	4.94	No	Yes	0	5	5
58	R:R:C333	R:R:S336	11.9188	5.16	No	No	0	9	5
59	R:R:F340	R:R:S336	13.907	5.28	No	No	0	8	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F76	R:R:R140	5.34	0	Yes	No	9	9	2	1
R:R:F76	R:R:N345	3.62	0	Yes	No	9	9	2	1
R:R:L82	R:R:Y341	3.52	0	No	Yes	9	9	2	1
R:R:N337	R:R:V133	4.43	1	No	No	9	8	2	2
R:R:V133	R:R:Y341	8.83	1	No	Yes	8	9	2	1
R:R:I224	R:R:N137	5.66	1	No	No	8	8	1	1
R:R:N137	R:R:Y341	3.49	1	No	Yes	8	9	1	1
R:R:N137	W:W:?1	10.24	1	No	Yes	8	0	1	0
R:R:E139	R:R:R140	8.14	0	No	No	9	9	2	1
R:R:R140	W:W:?1	14.35	0	No	Yes	9	0	1	0
R:R:V227	R:R:Y141	7.57	0	No	Yes	5	8	1	2
R:R:I224	W:W:?1	5.32	1	No	Yes	8	0	1	0
R:R:V227	W:W:?1	4.63	0	No	Yes	5	0	1	0
R:R:L289	R:R:Y228	14.07	0	No	No	8	9	2	1
R:R:Y228	W:W:?1	3.64	0	No	Yes	9	0	1	0
R:R:A285	R:R:M231	3.22	0	No	No	8	9	2	1
R:R:M231	W:W:?1	6.15	0	No	Yes	9	0	1	0
R:R:V288	W:W:?1	25	0	No	Yes	9	0	1	0
R:R:G293	R:R:V292	3.68	0	No	No	7	8	2	1
R:R:V292	W:W:?1	6.48	0	No	Yes	8	0	1	0
R:R:N337	R:R:Q295	3.96	1	No	Yes	9	6	2	2
R:R:Q295	R:R:Y341	6.76	1	Yes	Yes	6	9	2	1
R:R:N337	R:R:Y341	3.49	1	No	Yes	9	9	2	1
R:R:Y341	W:W:?1	5.1	1	Yes	Yes	9	0	1	0
R:R:C343	R:R:L344	3.17	0	No	No	5	7	2	1
R:R:L344	W:W:?1	11.18	0	No	Yes	7	0	1	0
R:R:I348	R:R:N345	8.5	0	Yes	No	8	9	2	1
R:R:N345	W:W:?1	8.53	0	No	Yes	9	0	1	0
R:R:A291	W:W:?1	2.94	0	No	Yes	7	0	1	0
R:R:R346	W:W:?1	2.27	0	No	Yes	7	0	1	0
R:R:I224	R:R:L225	1.43	1	No	No	8	4	1	2
R:R:V287	W:W:?1	0.93	0	No	Yes	7	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
38.89	Single	8XQL	Aristolochic acid A	8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
35.29	Single	8XQR	Flufenamic acid	8XQR-TAS2R14-Flufenamic acid-Gt3/β1/γ1
33.33	Single	8RQL	Flufenamic acid	8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
33.33	Single	8XQO	Aristolochic acid A	8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
33.33	Single	8XQS	Flufenamic acid	8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
33.33	Single	8ZYU	SBI-553	8ZYU-NTS₁-Neurotensin peptide 8-13-SBI-553-Arrestin2
33.33	Single	8ZYY	SBI-553	8ZYY-NTS₁-Neurotensin peptide 8-13-SBI-553-Arrestin2
31.58	Single	5XF1	NNC0640	5XF1-Glucagon-NNC0640
31.25	Single	5EE7	MK0893	5EE7-Glucagon-MK0893
29.41	Single	5VEX	NNC0640	5VEX-GLP-1-NNC0640
29.41	Single	6KK7	PF-06372222	6KK7-GLP-1-PF-06372222
29.17	Single	8ZYT	SBI-553	8ZYT-NTS₁-Neurotensin peptide 8-13-SBI-553-Arrestin2
27.78	Single	5VEW	PF-06372222	5VEW-GLP-1-PF-06372222
27.78	Single	6KJV	PF-06372222	6KJV-GLP-1-PF-06372222
27.78	Single	6KK1	PF-06372222	6KK1-GLP-1-PF-06372222
27.78	Single	8XQN	Aristolochic acid A	8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
26.32	Single	5XEZ	NNC0640	5XEZ-Glucagon-NNC0640
26.09	Single	6LN2	PF-06372222	6LN2-GLP-1-PF-06372222
25.00	Single	8JPF	SBI-553	8JPF-NTS₁-Neurotensin-SBI-553
24.00	Single	8FN0	SBI-553	8FN0-NTS₁-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
22.73	Single	8JPB	SBI-553; GDP; Mg	8JPB-NTS₁-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
22.22	Single	7CA3	rac-BHFF	7CA3-GABA_B1, GABA_B2-rac-BHFF
21.74	Single	5LWE	Vercirnon	5LWE-CCR9-Vercirnon
21.05	Single	7C7Q	BHFF	7C7Q-GABA_B1, GABA_B2-Baclofen-BHFF
19.05	Single	8JPC	SBI-553; GDP; Mg	8JPC-NTS₁-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
17.65	Single	7EB2	rac-BHFF	7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
17.39	Single	8J20	AR420626	8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
16.67	Single	8JR9	PCO371	8JR9-PTH1-PCO371-chim(NtGi1-Gs)/β1/γ2
16.67	Single	8XQP	Aristolochic acid A	8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
15.79	Single	5T1A	PubChem 12093170	5T1A-CCR2-BMS-681-PubChem 12093170
14.29	Single	5X7D	Cmpd-15	5X7D-β₂-S-Carazolol-Cmpd-15
13.64	Single	4Z9G	CP-376395	4Z9G-CRF₁-CP-376395
13.04	Single	6LFL	PubChem 153466996	6LFL-CXCR2-PubChem 153466996
13.04	Single	8GTG	BMK-I152	8GTG-CRF₁-BMK-I152
13.04	Single	8GW8	PCO371	8GW8-PTH1-PCO371-Gs/β1/γ2
12.50	Single	4PXF	Octyl-Beta-D-Glucopyranoside	4PXF-Rhodopsin-Octyl-β-D-Glucopyranoside-Arrestin1 Finger Loop
10.00	Single	8HNN	SCH546738	8HNN-CXCR3-SCH546738
9.52	Single	4K5Y	CP-376395	4K5Y-CRF₁-CP-376395
8.70	Single	6QZH	Cmp2105; Na	6QZH-CCR7-Cmp2105; Na
8.70	Single	8GTI	BMK-C205	8GTI-CRF₁-BMK-C205
7.69	Single	8GTM	BMK-C203	8GTM-CRF₁-BMK-C203
5.88	Single	3VG9	Antibody	3VG9-A_2A-ZM-241385-Antibody
5.88	Single	6UO8	GS39783	6UO8-GABA_B1, GABA_B2-SKF97541-GS39783
5.88	Single	7DUQ	PubChem 156022738	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
5.56	Single	9JCQ	LPC	9JCQ-GPR4-LPC-chim(NtGi1-Gs)/β1/γ2
5.41	Single	3VGA	Antibody	3VGA-A_2A-ZM-241385-Antibody
5.00	Single	8Y6W	4-CMTB	8Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
5.00	Single	9JCP	LPC	9JCP-GPR4-LPC-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Single	9JCO	LPC	9JCO-GPR4-LPC-chim(NtGi1-Gs)/β1/γ2
4.55	Single	9CLW	4-CMTB	9CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.35	Single	8XQL	Aristolochic acid A	8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.17	Single	6C1R	Avacopan; Na	6C1R-C5a₁-PMX53-Avacopan; Na
4.17	Single	7RBT	LSN3556672	7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2

PDB Summary
PDB	8TB7
Class	A
SubFamily	Orphan
Type	Orphan
SubType	GPR61
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	PubChem 168510218
Protein Partners	-
PDB Resolution	2.94
Date	2023-10-04
D.O.I.	doi.org/10.1038/s41467-023-41646-3

Net Summary
I_min	3.15
Number of Linked Nodes	187
Number of Links	198
Number of Hubs	21
Number of Links mediated by Hubs	91
Number of Communities	5
Number of Nodes involved in Communities	25
Number of Links involved in Communities	31

Path Summary
Number Of Nodes in MetaPath	60
Number Of Links MetaPath	59
Number of Shortest Paths	17832
Length Of Smallest Path	3
Average Path Length	12.7915
Length of Longest Path	27
Minimum Path Strength	1.35
Average Path Strength	6.04395
Maximum Path Strength	17.62
Minimum Path Correlation	0.7
Average Path Correlation	0.907106
Maximum Path Correlation	0.98
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	35.8805
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.1778
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • protein binding • arrestin family protein binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • signal transduction • cell communication • signal transduction in absence of ligand
Gene Ontology	Biological Process	• electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • signal transduction • cell communication • signal transduction in absence of ligand • ligand-independent adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cellular anatomical structure • periplasmic space • protein-containing complex • receptor complex • endosome membrane • membrane-bounded organelle • intracellular anatomical structure • membrane • endosome • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle membrane
Gene Ontology	Cellular Component	• cellular anatomical structure • periplasmic space • protein-containing complex • receptor complex • endosome membrane • membrane-bounded organelle • intracellular anatomical structure • membrane • endosome • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle membrane • bounding membrane of organelle • vesicle membrane • cytoplasmic vesicle • organelle • cytoplasm • vesicle • organelle membrane • cell periphery • plasma membrane
SCOP2	Domain Identifier	• Cytochromes
SCOP2	Family Identifier	• Cytochromes
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ZOB
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	ZOB
Name	6-{[(3,5-difluoropyridin-4-yl)methyl]amino}-N-(4-ethoxy-6-methylpyrimidin-2-yl)-2-methoxy-N-(2-methoxyethyl)pyridine-3-sulfonamide
Synonyms
Identifier
Formula	C22 H26 F2 N6 O5 S
Molecular Weight	524.541
SMILES
PubChem	168510218
Formal Charge	0
Total Atoms	62
Total Chiral Atoms	0
Total Bonds	64
Total Aromatic Bonds	18


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9BZJ8
Sequence	>8TB7_Chain_R S V A L F F M L L L D L T A V A G N A A V M A V I A K T P A L R K F V F V F H L C L V D L L A A L T L M P L A M L G E V A C R L Y L F L S V C F V S L A I L S V S A I N V E R Y Y Y V V H P M R Y E V R M T L G L V A S V L V G V W V K A L A M A S V P V L C Q L F V V V F A V L Y F L L P L L L I L V V Y C S M F R K A A V V L L A V G G Q F L L C W L P Y F S F H L Y V A Q V E S V V T W I G Y F C F T S N P F F Y G C L N R Q I R G Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8TB7	A	Orphan	Orphan	GPR61	Homo sapiens	-	PubChem 168510218	-	2.94	2023-10-04	doi.org/10.1038/s41467-023-41646-3
	8TB0	A	Orphan	Orphan	GPR61	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.47	2023-10-04	doi.org/10.1038/s41467-023-41646-3
	8TB0 (No Gprot)	A	Orphan	Orphan	GPR61	Homo sapiens	-	-		3.47	2023-10-04	doi.org/10.1038/s41467-023-41646-3
	8KGK	A	Orphan	Orphan	GPR61	Homo sapiens	-	-	Gs/β1/γ2	3.16	2023-10-11	doi.org/10.1038/s41467-023-41654-3
	8KGK (No Gprot)	A	Orphan	Orphan	GPR61	Homo sapiens	-	-		3.16	2023-10-11	doi.org/10.1038/s41467-023-41654-3

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8TB7.zip

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