Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:H41 5.356506
2A:A:K53 5.514119
3A:A:I56 5.745407
4A:A:F212 6.135409
5A:A:H220 6.7975417
6A:A:M221 5.42254118
7A:A:F222 11.7417
8A:A:Q227 8.014519
9A:A:R232 7.6375418
10A:A:K233 7.28719
11A:A:W234 8.944519
12A:A:F238 9.326519
13A:A:S251 5.21254149
14A:A:D252 5.5654148
15A:A:Y253 7.32667648
16A:A:F273 5.5925209
17A:A:W277 9.2625206
18A:A:W281 14.475415
19A:A:F290 5.02754169
20A:A:Q294 5.365646
21A:A:F315 12.9425406
22A:A:E330 5.4525403
23A:A:F340 9.435197
24A:A:R342 6.535444
25A:A:E344 5.78754195
26A:A:F345 8.75408
27A:A:Y360 6.4985158
28A:A:F363 6.95545
29A:A:T364 7.094169
30A:A:D368 6.5554169
31A:A:N371 7.59254169
32A:A:F376 6.13408
33A:A:R385 5.23254155
34A:A:Q390 6.1775484
35A:A:Y391 7.7275484
36A:A:L393 5.3375408
37B:B:I18 5.32527
38B:B:D27 5.76254228
39B:B:L30 6.2275405
40B:B:I37 3.4375402
41B:B:V40 5.2885233
42B:B:K57 14.792519
43B:B:W63 6.485677
44B:B:R68 11.6825465
45B:B:V71 5.58408
46B:B:Q75 10.384519
47B:B:I80 4.755408
48B:B:K89 5.88569
49B:B:L95 4.9754258
50B:B:W99 12.93419
51B:B:Y105 5.3325406
52B:B:Y111 6.8325404
53B:B:Y124 6.026506
54B:B:E138 7.04406
55B:B:H142 8.224599
56B:B:Y145 7.02833618
57B:B:F151 4.677269
58B:B:L152 4.474533
59B:B:Q156 5.8325435
60B:B:D163 7.724599
61B:B:L168 5.3275436
62B:B:W169 9.60833698
63B:B:F180 9.844537
64B:B:H183 9.73333639
65B:B:D186 8.096519
66B:B:F199 9.0925439
67B:B:C204 5.62517
68B:B:D205 7.015439
69B:B:K209 11.2625436
70B:B:W211 9.41714738
71B:B:F222 7.782528
72B:B:H225 8.35429729
73B:B:D228 8.672519
74B:B:I229 6.4275427
75B:B:F234 4.696505
76B:B:F235 10.675176
77B:B:P236 6.75254177
78B:B:N237 8.2475405
79B:B:F241 9.29167626
80B:B:D246 5.8725419
81B:B:D247 9.8525429
82B:B:F253 8.138526
83B:B:Q259 4.2625406
84B:B:M262 5.4825404
85B:B:Y264 7.5025405
86B:B:F278 5.868336177
87B:B:R283 6.638336239
88B:B:Y289 7.714297127
89B:B:D290 6.808516
90B:B:W297 11.37254128
91B:B:R304 8.064125
92B:B:H311 11.34459
93B:B:R314 16.088518
94B:B:T321 7.7475477
95B:B:W332 13.936519
96B:B:D333 6.135459
97B:B:K337 10.25556
98B:B:W339 10.514559
99B:B:N340 5.55754249
100G:G:L19 5.7575409
101G:G:R27 6.22528
102G:G:D48 6.45459
103G:G:L50 6.1975459
104G:G:V54 6.37254246
105G:G:F61 6.26478
106R:R:N60 8.2525409
107R:R:M64 5.855407
108R:R:F76 7.044589
109R:R:F78 7.745408
110R:R:H81 7.3375409
111R:R:L82 7.3954139
112R:R:D86 9.994139
113R:R:L93 7.73754108
114R:R:R116 4.884187
115R:R:Y118 4.706676106
116R:R:F120 4.1975406
117R:R:F125 6.75407
118R:R:R140 6.5825409
119R:R:Y141 7.8025408
120R:R:Y143 14.052588
121R:R:V176 4.20254286
122R:R:Q198 6.36404
123R:R:W199 6.35254306
124R:R:Y216 8.991437296
125R:R:Y228 4.255609
126R:R:F296 6.4025409
127R:R:W300 7.957147138
128R:R:Y303 9.724317
129R:R:F304 8.468507
130R:R:F306 6.1556325
131R:R:W328 9.02333605
132R:R:Y331 6.8656108
133R:R:F334 8.25409
134R:R:N337 7.80254139
135R:R:N345 8.005489
136R:R:I348 5.9525488
137R:R:L352 2.995407
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:I80 B:B:K78 98.1424.36YesNo088
2B:B:D76 B:B:L55 98.45386.79NoNo096
3B:B:D76 B:B:K78 97.99535.53NoNo098
4A:A:Y37 B:B:L55 97.91594.69NoNo046
5A:A:R42 A:A:Y37 97.953314.4NoNo094
6A:A:H41 A:A:I383 28.25525.3YesNo068
7A:A:H387 A:A:I383 28.76096.63NoNo088
8A:A:H387 R:R:Y143 30.799133.76NoYes088
9A:A:Q390 R:R:Y143 15.07247.89YesYes848
10A:A:Q390 R:R:Q347 24.01833.84YesNo847
11R:R:L73 R:R:Q347 24.21365.32NoNo887
12R:R:E351 R:R:L73 96.78993.98NoNo088
13R:R:E351 R:R:T70 97.503611.29NoNo086
14R:R:P71 R:R:T70 97.85883.5NoNo066
15B:B:R52 R:R:P71 98.03398.65NoNo076
16B:B:R52 B:B:T50 97.904512.94NoNo073
17B:B:T47 B:B:T50 48.86054.71NoNo533
18B:B:T47 B:B:W339 48.917210.92NoYes539
19B:B:M45 B:B:W339 99.89244.65NoYes549
20B:B:M45 G:G:L50 1004.24NoYes549
21G:G:D48 G:G:L50 99.18794.07YesYes599
22B:B:K280 G:G:D48 99.09845.53NoYes019
23B:B:G324 B:B:K280 99.04443.49NoNo091
24B:B:G324 B:B:T321 99.02593.64NoYes097
25B:B:T321 B:B:W63 98.64312.13YesYes777
26B:B:S84 B:B:W63 98.46926.18NoYes757
27R:R:K75 R:R:Y143 15.09614.78NoYes078
28R:R:F76 R:R:K75 15.3217.44YesNo097
29R:R:F76 R:R:L73 72.3973.65YesNo898
30B:B:K337 B:B:T50 49.21889.01YesNo563
31B:B:K337 B:B:W339 50.076910.44YesYes569
32A:A:H41 A:A:T242 14.42396.85YesNo068
33A:A:F222 A:A:R42 97.06645.34YesNo179
34A:A:L43 A:A:T242 13.40874.42NoNo078
35A:A:F238 B:B:W99 30.240813.03YesYes199
36A:A:F222 B:B:W99 97.569223.05YesYes179
37A:A:F340 A:A:I341 11.19113.77YesNo078
38A:A:E344 A:A:F340 18.34969.33YesYes1957
39A:A:E344 A:A:L270 19.67163.98YesNo056
40A:A:F345 A:A:L270 20.572110.96YesNo086
41A:A:F345 A:A:L289 24.59139.74YesNo089
42A:A:F246 A:A:L289 24.79683.65NoNo099
43A:A:F246 A:A:L272 25.00217.31NoNo098
44A:A:L272 A:A:R231 26.02266.07NoNo089
45A:A:R231 A:A:W234 26.22629NoYes099
46A:A:F238 A:A:W234 28.8974.01YesYes199
47B:B:Q75 B:B:W99 82.80057.67YesYes199
48B:B:K57 B:B:Q75 81.836817.63YesYes199
49B:B:K57 B:B:W332 83.168127.85YesYes199
50B:B:R314 B:B:W332 82.936221.99YesYes189
51B:B:D290 B:B:R314 82.318710.72YesYes168
52B:B:C271 B:B:D290 82.10094.67NoYes156
53R:R:R140 R:R:Y228 16.98886.17YesYes099
54A:A:Y391 R:R:R140 19.369610.29YesYes049
55B:B:C271 B:B:D291 82.21446.22NoNo058
56B:B:D291 B:B:Y289 81.9215.75NoYes087
57B:B:C250 B:B:Y289 39.88834.03NoYes1287
58B:B:C250 B:B:Y264 39.82034.03NoYes085
59B:B:M262 B:B:Y264 60.08055.99YesYes045
60B:B:L261 B:B:M262 57.85524.24NoYes054
61B:B:D254 B:B:L261 57.22629.5NoNo095
62B:B:A257 B:B:D254 56.59764.63NoNo079
63B:B:A257 G:G:V30 56.2843.39NoNo078
64B:B:Q259 G:G:V30 54.08274.3YesNo068
65B:B:Q259 B:B:R22 53.14057.01YesNo066
66B:B:I18 B:B:R22 51.00398.77YesNo276
67B:B:I18 B:B:L14 51.00075.71YesNo078
68B:B:L14 G:G:L19 48.64986.92NoYes089
69B:B:W297 B:B:Y289 40.562211.58YesYes1287
70B:B:W297 B:B:Y264 39.921410.61YesYes085
71B:B:I338 B:B:L51 97.43534.28NoNo059
72B:B:I80 B:B:W82 96.67487.05YesNo089
73B:B:L51 B:B:W82 96.737613.67NoNo099
74G:G:E22 G:G:L19 44.039211.93NoYes099
75B:B:T221 G:G:E22 43.70164.23NoNo079
76B:B:K209 B:B:T221 43.363710.51YesNo067
77B:B:K209 B:B:W211 38.4035.8YesYes368
78B:B:F180 B:B:W211 35.457119.04YesYes378
79B:B:F180 B:B:L168 34.06496.09YesYes376
80B:B:L168 B:B:Q156 32.66986.65YesYes365
81B:B:D153 B:B:Q156 31.00986.53NoYes055
82B:B:D153 B:B:D154 28.21425.32NoNo056
83B:B:D154 B:B:S108 27.86354.42NoNo066
84B:B:N110 B:B:S108 27.512510.43NoNo046
85B:B:N110 B:B:Y111 27.16123.49NoYes044
86B:B:I123 B:B:Y111 12.14873.63NoYes064
87B:B:F151 B:B:I123 11.41683.77YesNo2696
88B:B:N125 B:B:Y111 14.685715.12NoYes044
89B:B:N125 B:B:T128 14.32425.85NoNo043
90B:B:E130 B:B:T128 13.96239.88NoNo033
91B:B:E130 B:B:N132 13.23776.57NoNo033
92B:B:N132 B:B:V133 12.8752.96NoNo034
93B:B:I93 B:B:V133 12.5126.14NoNo074
94B:B:I93 B:B:Y124 11.785112.09NoYes076
95B:B:L285 B:B:Y264 19.85539.38NoYes065
96B:B:F278 B:B:L285 18.79038.53YesNo076
97B:B:F235 B:B:F278 16.085910.72YesYes1767
98B:B:F235 B:B:N237 15.201913.29YesYes065
99B:B:G238 B:B:N237 13.76723.39NoYes075
100B:B:F234 B:B:G238 13.45314.52YesNo057
101B:B:F234 B:B:V200 12.19525.24YesNo056
102B:B:F241 B:B:V200 10.850719.66YesNo266
103R:R:F76 R:R:I348 48.12245.02YesYes898
104R:R:I348 R:R:V79 46.47484.61YesNo088
105R:R:I136 R:R:V79 46.02546.14NoNo098
106R:R:I136 R:R:L82 48.57924.28NoYes099
107R:R:D86 R:R:L82 26.45045.43YesYes1399
108R:R:D86 R:R:F334 22.14814.33YesYes099
109R:R:F334 R:R:Y331 15.09516.19YesYes098
110R:R:L82 R:R:N337 18.226412.36YesYes1399
111R:R:C333 R:R:N337 17.39686.3NoYes1399
112R:R:C333 R:R:W300 16.87189.14NoYes1398
113R:R:F304 R:R:W300 10.23897.02YesYes078
114R:R:H307 R:R:Y303 16.43517.42NoYes3167
115R:R:H307 R:R:Q198 15.913412.36NoYes064
116R:R:Q198 R:R:V310 10.10824.3YesNo044
117B:B:I338 B:B:S84 96.3264.64NoNo755
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8KGK
Class A
SubFamily Orphan
Type Orphan
SubType GPR61
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 3.16
Date 2023-10-11
D.O.I. doi.org/10.1038/s41467-023-41654-3
Net Summary
Imin 3.49
Number of Linked Nodes 819
Number of Links 953
Number of Hubs 137
Number of Links mediated by Hubs 528
Number of Communities 33
Number of Nodes involved in Communities 224
Number of Links involved in Communities 300
Path Summary
Number Of Nodes in MetaPath 118
Number Of Links MetaPath 117
Number of Shortest Paths 996487
Length Of Smallest Path 3
Average Path Length 45.9135
Length of Longest Path 90
Minimum Path Strength 1.2
Average Path Strength 7.86378
Maximum Path Strength 25.61
Minimum Path Correlation 0.7
Average Path Correlation 0.976836
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.5873
Average % Of Corr. Nodes 38.9013
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 43.7554
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8KGK_Chain_A
QRNEEKAQR EANKKIEKQ LQKDKQVYR ATHRLLLLG ADNSGKSTI 
VKQMRGIFE TKFQVDKVN FHMFDVGGQ RDERRKWIQ CFNDVTAII 
FVVDSSDYN RLQEALNLF KSIWNNRWL RTISVILFL NKQDLLAEK 
VLAGKSKIE DYFPEFARY TTPEDATPE PGEDPRVTR AKYFIRDEF 
LRISTASGD GRHYCYPHF TCAVDTENA RRIFNDCRD IIQRMHLRQ 
YELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8KGK_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8KGK_Chain_G
SIAQARKLV EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT 
PVPASENPF RE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ9BZJ8
Sequence
>8KGK_Chain_R
SVALFFMLL LDLTAVAGN AAVMAVIAK TPALRKFVF VFHLCLVDL 
LAALTLMPL AMLSSSAGE VACRLYLFL SVCFVSLAI LSVSAINVE 
RYYYVVHPM RYEVRMTLG LVASVLVGV WVKALAMAS VPVLGRVSW 
EPPGCSLQW SHSAYCQLF VVVFAVLYF LLPLLLILV VYCSMFRVA 
RVAGKAAVV LLAVGGQFL LCWLPYFSF HLYVALSAQ PISTGQVES 
VVTWIGYFC FTSNPFFYG CLNRQIRGE LSKQ


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8TB7AOrphanOrphanGPR61Homo sapiens-PubChem 168510218-2.942023-10-04doi.org/10.1038/s41467-023-41646-3
8TB0AOrphanOrphanGPR61Homo sapiens--chim(NtGi1-Gs)/β1/γ23.472023-10-04doi.org/10.1038/s41467-023-41646-3
8TB0 (No Gprot) AOrphanOrphanGPR61Homo sapiens--3.472023-10-04doi.org/10.1038/s41467-023-41646-3
8KGKAOrphanOrphanGPR61Homo sapiens--Gs/β1/γ23.162023-10-11doi.org/10.1038/s41467-023-41654-3
8KGK (No Gprot) AOrphanOrphanGPR61Homo sapiens--3.162023-10-11doi.org/10.1038/s41467-023-41654-3




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8KGK.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.