Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:M49 8.5575406
2R:R:N60 8.2525409
3R:R:M64 5.855407
4R:R:K69 6.0375446
5R:R:T70 6.37446
6R:R:F76 7.044549
7R:R:F78 7.745408
8R:R:H81 7.3375409
9R:R:L82 7.3954129
10R:R:D86 9.994129
11R:R:L93 7.7375498
12R:R:E112 8.344184
13R:R:R116 8.664187
14R:R:Y118 4.70667696
15R:R:F120 4.1975406
16R:R:F125 6.75407
17R:R:R140 6.5825409
18R:R:Y141 7.8025408
19R:R:Y143 14.052548
20R:R:E185 5.27254183
21R:R:Q198 6.36404
22R:R:W199 6.58754236
23R:R:Y216 8.991437226
24R:R:Y228 4.255609
25R:R:F296 6.4025409
26R:R:W300 7.957147128
27R:R:Y303 9.724247
28R:R:F304 8.468507
29R:R:F306 6.1556265
30R:R:W328 8.44333605
31R:R:Y331 6.865698
32R:R:F334 8.25409
33R:R:N337 7.80254129
34R:R:N345 8.005449
35R:R:I348 5.9525448
36R:R:E351 7.1925448
37A:A:Q19 9.5175474
38A:A:H41 5.356506
39A:A:K53 5.514139
40A:A:I56 5.745407
41A:A:F212 6.135409
42A:A:H220 6.7975417
43A:A:M221 5.42254138
44A:A:F222 11.7417
45A:A:Q227 10.24419
46A:A:R232 7.6375418
47A:A:K233 7.28719
48A:A:W234 9.602519
49A:A:F238 9.326519
50A:A:D249 9.984108
51A:A:D252 7.234108
52A:A:Y253 7.32667658
53A:A:L272 5.41408
54A:A:F273 5.5925289
55A:A:W277 9.2625286
56A:A:W281 14.475415
57A:A:F290 5.02754199
58A:A:Q294 5.365656
59A:A:F315 12.9425406
60A:A:E330 5.4525403
61A:A:F340 9.435167
62A:A:R342 6.535454
63A:A:E344 4.8625165
64A:A:F345 8.75408
65A:A:Y360 6.9585158
66A:A:F363 6.95555
67A:A:T364 7.094199
68A:A:D368 6.5554199
69A:A:N371 7.59254199
70A:A:F376 6.13408
71A:A:R385 5.23254155
72A:A:Q390 6.1775444
73A:A:Y391 7.7275444
74A:A:L393 5.3375408
75B:B:R22 6.4225426
76B:B:D27 5.415408
77B:B:L30 6.2275405
78B:B:I37 3.4375402
79B:B:V40 5.2885303
80B:B:K57 14.792519
81B:B:W63 6.485687
82B:B:R68 9.246575
83B:B:L69 4.47475
84B:B:V71 5.58408
85B:B:Q75 10.384519
86B:B:I80 4.755408
87B:B:K89 5.88579
88B:B:L95 4.9754318
89B:B:W99 12.93419
90B:B:Y105 5.3325406
91B:B:Y111 6.8325404
92B:B:Y124 6.026506
93B:B:E138 7.04406
94B:B:H142 8.2245119
95B:B:Y145 6.08833618
96B:B:F151 4.677329
97B:B:L152 4.474533
98B:B:Q156 5.8325435
99B:B:D163 7.7245119
100B:B:L168 5.3275436
101B:B:W169 9.608336118
102B:B:F180 9.844537
103B:B:H183 9.73333639
104B:B:D186 8.096519
105B:B:F199 9.0925439
106B:B:C204 5.62517
107B:B:D205 7.015439
108B:B:K209 11.2625436
109B:B:W211 9.41714738
110B:B:E215 7.89254333
111B:B:F222 7.782528
112B:B:H225 8.35429729
113B:B:D228 8.672519
114B:B:I229 6.4275427
115B:B:F234 4.696505
116B:B:F235 10.675206
117B:B:P236 6.75254207
118B:B:N237 8.2475405
119B:B:F241 9.29167626
120B:B:D246 5.8725419
121B:B:D247 9.8525429
122B:B:F253 8.138526
123B:B:D258 11.475427
124B:B:M262 5.4825404
125B:B:Y264 7.5025405
126B:B:F278 5.868336207
127B:B:R283 6.638336309
128B:B:Y289 7.714297147
129B:B:D290 6.808516
130B:B:W297 11.37254148
131B:B:K301 6.715405
132B:B:R304 8.064145
133B:B:H311 11.34469
134B:B:R314 16.088518
135B:B:T321 7.7475487
136B:B:W332 13.936519
137B:B:D333 6.135469
138B:B:K337 10.25566
139B:B:W339 10.514569
140B:B:N340 5.55754179
141G:G:D48 6.45469
142G:G:L50 6.1975469
143G:G:V54 6.01754176
144G:G:F61 5.562588
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:D86 R:R:F334 22.915914.33YesYes099
2R:R:F334 R:R:Y331 17.23866.19YesYes098
3R:R:D86 R:R:L82 27.12235.43YesYes1299
4R:R:I136 R:R:L82 50.92514.28NoYes099
5R:R:I136 R:R:V79 48.01286.14NoNo098
6R:R:I348 R:R:V79 48.44744.61YesNo088
7R:R:F76 R:R:I348 49.61585.02YesYes498
8R:R:F76 R:R:L73 73.23613.65YesNo498
9R:R:E351 R:R:L73 96.96523.98YesNo488
10R:R:E351 R:R:T70 97.113611.29YesYes486
11R:R:P71 R:R:T70 98.14673.5NoYes066
12B:B:R52 R:R:P71 98.31218.65NoNo076
13A:A:Y391 R:R:R140 19.297110.29YesYes049
14A:A:Q390 R:R:Q347 23.37223.84YesNo447
15R:R:F76 R:R:K75 14.81277.44YesNo097
16R:R:K75 R:R:Y143 14.5934.78NoYes078
17R:R:F304 R:R:Y303 10.21279.28YesYes077
18R:R:T327 R:R:Y303 10.33417.49NoYes067
19R:R:T327 R:R:Y331 10.58676.24NoYes068
20R:R:F304 R:R:W300 11.41847.02YesYes078
21R:R:R140 R:R:Y228 16.83756.17YesYes099
22A:A:H387 R:R:Y143 30.000533.76NoYes088
23A:A:H41 A:A:I383 27.48185.3YesNo068
24A:A:H387 A:A:I383 27.98246.63NoNo088
25R:R:H307 R:R:Y303 18.896517.42NoYes2467
26R:R:H307 R:R:Q198 18.382312.36NoYes064
27A:A:L43 A:A:T242 12.77484.42NoNo078
28A:A:H41 A:A:T242 13.78076.85YesNo068
29R:R:C333 R:R:N337 18.72586.3NoYes1299
30B:B:S84 B:B:W63 98.02436.18NoYes857
31B:B:T321 B:B:W63 98.274412.13YesYes877
32B:B:G324 B:B:T321 98.4443.64NoYes097
33B:B:G324 B:B:K280 98.4773.49NoNo091
34B:B:K280 G:G:D48 98.57415.53NoYes019
35G:G:D48 G:G:L50 99.04134.07YesYes699
36B:B:M45 G:G:L50 1004.24NoYes649
37B:B:M45 B:B:W339 99.90794.65NoYes649
38B:B:T47 B:B:W339 48.984610.92NoYes639
39B:B:T47 B:B:T50 48.93554.71NoNo633
40B:B:R52 B:B:T50 98.095812.94NoNo073
41B:B:K337 B:B:W339 50.121110.44YesYes669
42B:B:K337 B:B:T50 49.32549.01YesNo663
43B:B:I80 B:B:W82 89.05117.05YesNo089
44B:B:L51 B:B:W82 89.168513.67NoNo099
45B:B:I338 B:B:L51 89.98284.28NoNo059
46B:B:I338 B:B:S84 88.18774.64NoNo855
47B:B:D76 B:B:L55 93.26076.79NoNo096
48B:B:D76 B:B:K78 92.88365.53NoNo098
49B:B:I80 B:B:K78 93.07164.36YesNo088
50A:A:Y37 B:B:L55 92.39544.69NoNo046
51A:A:R42 A:A:Y37 92.573114.4NoNo094
52A:A:F222 A:A:R42 91.55525.34YesNo179
53A:A:F238 B:B:W99 27.241513.03YesYes199
54A:A:F222 B:B:W99 91.940923.05YesYes179
55A:A:L272 A:A:R231 22.47016.07YesNo089
56A:A:R231 A:A:W234 22.68439NoYes099
57A:A:F238 A:A:W234 25.81664.01YesYes199
58B:B:R314 B:B:W332 74.976221.99YesYes189
59B:B:K57 B:B:W332 75.319327.85YesYes199
60B:B:K57 B:B:Q75 74.210817.63YesYes199
61B:B:Q75 B:B:W99 75.30177.67YesYes199
62A:A:F246 A:A:L272 19.00247.31NoYes098
63A:A:F246 A:A:L289 18.78293.65NoNo099
64A:A:F345 A:A:L289 18.56329.74YesNo089
65A:A:E344 A:A:F340 12.10549.33YesYes1657
66A:A:E344 A:A:L270 13.73173.98YesNo056
67A:A:F345 A:A:L270 14.522410.96YesNo086
68B:B:D290 B:B:R314 74.257210.72YesYes168
69B:B:C271 B:B:D290 73.95934.67NoYes156
70B:B:M262 B:B:Y264 12.25875.99YesYes045
71B:B:C250 B:B:Y264 35.544.03NoYes085
72B:B:C250 B:B:Y289 35.63644.03NoYes1487
73B:B:D291 B:B:Y289 73.65825.75NoYes087
74B:B:C271 B:B:D291 74.02316.22NoNo058
75B:B:W297 B:B:Y264 35.628110.61YesYes085
76B:B:W297 B:B:Y289 36.371911.58YesYes1487
77B:B:I157 B:B:W169 12.26463.52NoYes078
78B:B:F151 B:B:I157 12.655412.56YesNo097
79B:B:F151 B:B:I123 15.37653.77YesNo3296
80B:B:I123 B:B:Y111 16.15893.63NoYes064
81B:B:N110 B:B:Y111 18.85873.49NoYes044
82B:B:N110 B:B:S108 21.593210.43NoNo046
83B:B:D154 B:B:S108 21.97734.42NoNo066
84B:B:D153 B:B:D154 22.36115.32NoNo056
85B:B:D153 B:B:Q156 25.42056.53NoYes055
86B:B:L168 B:B:Q156 27.25896.65YesYes365
87B:B:F180 B:B:L168 28.78256.09YesYes376
88B:B:F180 B:B:G216 38.93174.52YesNo074
89B:B:E215 B:B:G216 39.30173.27YesNo034
90B:B:E215 B:B:R219 40.00916.28YesNo3335
91B:B:L210 B:B:R219 40.76254.86NoNo055
92B:B:L210 B:B:L255 41.89945.54NoNo056
93B:B:F241 B:B:L255 41.43083.65YesNo266
94B:B:F241 B:B:V200 48.595719.66YesNo266
95B:B:F234 B:B:V200 50.06935.24YesNo056
96B:B:F234 B:B:G238 51.47064.52YesNo057
97B:B:G238 B:B:N237 51.82073.39NoYes075
98B:B:F235 B:B:N237 53.80413.29YesYes065
99B:B:F235 B:B:F278 54.803310.72YesYes2067
100B:B:F278 B:B:L285 57.69118.53YesNo076
101B:B:L285 B:B:Y264 58.73899.38NoYes065
102B:B:L69 B:B:R68 10.09693.64YesYes755
103R:R:C333 R:R:W300 18.20739.14NoYes1298
104A:A:Q390 R:R:Y143 14.56577.89YesYes448
105R:R:L82 R:R:N337 20.018112.36YesYes1299
106R:R:L73 R:R:Q347 23.5595.32NoNo487
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8KGK
Class A
SubFamily Orphan
Type A orphans
SubType GPR61
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 3.16
Date 2023-10-11
D.O.I. 10.1038/s41467-023-41654-3
Net Summary
Imin 3.49
Number of Linked Nodes 826
Number of Links 971
Number of Hubs 144
Number of Links mediated by Hubs 546
Number of Communities 34
Number of Nodes involved in Communities 237
Number of Links involved in Communities 321
Path Summary
Number Of Nodes in MetaPath 107
Number Of Links MetaPath 106
Number of Shortest Paths 929980
Length Of Smallest Path 3
Average Path Length 43.3036
Length of Longest Path 89
Minimum Path Strength 1.215
Average Path Strength 7.84202
Maximum Path Strength 25.61
Minimum Path Correlation 0.7
Average Path Correlation 0.976478
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.5873
Average % Of Corr. Nodes 39.5535
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 48.0956
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ9BZJ8
Sequence
>8KGK_Chain_R
SVALFFMLL LDLTAVAGN AAVMAVIAK TPALRKFVF VFHLCLVDL 
LAALTLMPL AMLSSSAGE VACRLYLFL SVCFVSLAI LSVSAINVE 
RYYYVVHPM RYEVRMTLG LVASVLVGV WVKALAMAS VPVLGRVSW 
EPPGCSLQW SHSAYCQLF VVVFAVLYF LLPLLLILV VYCSMFRVA 
RVAGKAAVV LLAVGGQFL LCWLPYFSF HLYVALSAQ PISTGQVES 
VVTWIGYFC FTSNPFFYG CLNRQIRGE LSKQ


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8KGK_Chain_A
QRNEEKAQR EANKKIEKQ LQKDKQVYR ATHRLLLLG ADNSGKSTI 
VKQMRGIFE TKFQVDKVN FHMFDVGGQ RDERRKWIQ CFNDVTAII 
FVVDSSDYN RLQEALNLF KSIWNNRWL RTISVILFL NKQDLLAEK 
VLAGKSKIE DYFPEFARY TTPEDATPE PGEDPRVTR AKYFIRDEF 
LRISTASGD GRHYCYPHF TCAVDTENA RRIFNDCRD IIQRMHLRQ 
YELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8KGK_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8KGK_Chain_G
SIAQARKLV EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT 
PVPASENPF RE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8KGKAOrphanA orphansGPR61Homo sapiens--Gs/&β;1/&γ;23.162023-10-1110.1038/s41467-023-41654-3
8TB0AOrphanA orphansGPR61Homo sapiens--chim(NtGi1-Gs)/&β;1/&γ;23.472023-10-0410.1038/s41467-023-41646-3
8TB7AOrphanA orphansGPR61Homo sapiens-PubChem 168510218-2.942023-10-0410.1038/s41467-023-41646-3




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8KGK.zip



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