psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F48	R:R:V44	3.93	No	No	0	4	5
2	R:R:F47	R:R:L46	4.87	No	No	0	4	5
3	R:R:F48	R:R:L51	3.65	No	No	0	4	4
4	R:R:M49	R:R:W328	30.24	No	Yes	0	6	5
5	R:R:D53	R:R:L50	5.43	No	No	0	7	3
6	R:R:L52	R:R:W328	6.83	No	Yes	0	6	5
7	R:R:C83	R:R:N60	6.3	No	Yes	0	9	9
8	R:R:D86	R:R:N60	12.12	Yes	Yes	0	9	9
9	R:R:N60	R:R:P338	13.03	Yes	No	0	9	9
10	R:R:C83	R:R:V63	5.12	No	No	0	9	9
11	R:R:F80	R:R:M64	7.46	No	Yes	0	5	7
12	R:R:L84	R:R:M64	5.65	No	Yes	0	5	7
13	R:R:L87	R:R:M64	7.07	No	Yes	0	7	7
14	R:R:L352	R:R:V66	5.96	Yes	No	0	7	7
15	R:R:F80	R:R:I67	7.54	No	No	0	5	7
16	R:R:E351	R:R:T70	11.29	No	No	0	8	6
17	R:R:F76	R:R:L73	3.65	Yes	No	3	9	8
18	R:R:L73	R:R:Q347	5.32	No	No	3	8	7
19	R:R:E351	R:R:L73	3.98	No	No	0	8	8
20	R:R:F76	R:R:K75	7.44	Yes	No	0	9	7
21	R:R:K75	R:R:Y143	4.78	No	No	0	7	8
22	R:R:F76	R:R:N345	12.08	Yes	No	3	9	9
23	R:R:F76	R:R:Q347	7.03	Yes	No	3	9	7
24	R:R:F76	R:R:I348	5.02	Yes	Yes	3	9	8
25	R:R:V159	R:R:V77	4.81	No	No	0	7	4
26	R:R:A135	R:R:F78	6.93	No	Yes	0	7	8
27	R:R:E139	R:R:F78	15.16	No	Yes	0	9	8
28	R:R:F78	R:R:V162	5.24	Yes	No	0	8	6
29	R:R:F78	R:R:L163	3.65	Yes	No	0	8	7
30	R:R:I136	R:R:V79	6.14	No	No	0	9	8
31	R:R:I348	R:R:V79	4.61	Yes	No	0	8	8
32	R:R:H81	R:R:V85	6.92	Yes	No	0	9	8
33	R:R:H81	R:R:S132	8.37	Yes	No	0	9	8
34	R:R:H81	R:R:L163	7.71	Yes	No	0	9	7
35	R:R:H81	R:R:W167	6.35	Yes	No	0	9	9
36	R:R:D86	R:R:L82	5.43	Yes	Yes	2	9	9
37	R:R:L82	R:R:S132	7.51	Yes	No	0	9	8
38	R:R:I136	R:R:L82	4.28	No	Yes	0	9	9
39	R:R:L82	R:R:N337	12.36	Yes	Yes	2	9	9
40	R:R:L84	R:R:L88	5.54	No	No	0	5	7
41	R:R:L128	R:R:V85	8.94	No	No	0	7	8
42	R:R:D86	R:R:F334	14.33	Yes	Yes	0	9	9
43	R:R:D86	R:R:N337	8.08	Yes	Yes	2	9	9
44	R:R:A89	R:R:F125	9.71	No	Yes	0	7	7
45	R:R:A89	R:R:F334	8.32	No	Yes	0	7	9
46	R:R:F125	R:R:T92	3.89	Yes	No	0	7	5
47	R:R:L93	R:R:S122	6.01	No	No	1	8	8
48	R:R:F125	R:R:L93	8.53	Yes	No	0	7	8
49	R:R:L93	R:R:Y331	12.89	No	Yes	1	8	8
50	R:R:M94	R:R:W328	5.82	No	Yes	0	7	5
51	R:R:A97	R:R:Y118	4	No	Yes	0	7	6
52	R:R:A97	R:R:W328	5.19	No	Yes	0	7	5
53	R:R:E112	R:R:R181	6.98	No	No	4	4	6
54	R:R:E112	R:R:E185	6.34	No	No	4	4	3
55	R:R:R116	R:R:V113	6.54	No	No	0	7	1
56	R:R:C115	R:R:C195	5.46	No	No	1	9	9
57	R:R:R116	R:R:V178	5.23	No	No	0	7	6
58	R:R:R116	R:R:R181	4.26	No	No	0	7	6
59	R:R:L117	R:R:L121	6.92	No	No	0	3	5
60	R:R:S122	R:R:Y118	8.9	No	Yes	1	8	6
61	R:R:Y118	R:R:Y331	5.96	Yes	Yes	1	6	8
62	R:R:F120	R:R:L121	4.87	Yes	No	0	6	5
63	R:R:A174	R:R:F120	5.55	No	Yes	0	8	6
64	R:R:F120	R:R:V178	3.93	Yes	No	0	6	6
65	R:R:F125	R:R:L121	4.87	Yes	No	0	7	5
66	R:R:S122	R:R:Y331	5.09	No	Yes	1	8	8
67	R:R:F212	R:R:V126	3.93	No	No	0	6	7
68	R:R:V126	R:R:W300	7.36	No	Yes	0	7	8
69	R:R:S127	R:R:Y216	10.17	No	Yes	0	7	6
70	R:R:L128	R:R:W167	19.36	No	No	0	7	9
71	R:R:A129	R:R:F334	4.16	No	Yes	0	9	9
72	R:R:I130	R:R:Y216	8.46	No	Yes	0	8	6
73	R:R:I130	R:R:W300	9.4	No	Yes	0	8	8
74	R:R:L131	R:R:V166	7.45	No	No	0	6	6
75	R:R:L131	R:R:Y216	10.55	No	Yes	0	6	6
76	R:R:V133	R:R:Y341	10.09	No	No	0	8	9
77	R:R:P220	R:R:S134	3.56	No	No	0	9	6
78	R:R:I136	R:R:R140	5.01	No	No	0	9	9
79	R:R:I224	R:R:N137	8.5	No	No	0	8	8
80	R:R:N137	R:R:Y341	10.47	No	No	0	8	9
81	R:R:R140	R:R:Y228	6.17	No	Yes	0	9	9
82	R:R:L344	R:R:R140	4.86	No	No	0	7	9
83	R:R:Y141	R:R:Y142	5.96	Yes	No	0	8	5
84	R:R:V145	R:R:Y141	12.62	No	Yes	0	6	8
85	R:R:V227	R:R:Y141	10.09	No	Yes	0	5	8
86	R:R:Y143	R:R:Y150	16.88	No	No	0	8	7
87	R:R:M231	R:R:V144	7.61	No	No	0	9	8
88	R:R:H146	R:R:V145	8.3	No	No	0	6	6
89	R:R:H146	R:R:R149	13.54	No	No	0	6	5
90	R:R:M154	R:R:Y150	16.76	No	No	0	6	7
91	R:R:G165	R:R:V164	3.68	No	No	0	1	2
92	R:R:K169	R:R:M173	10.08	No	No	5	4	6
93	R:R:K169	R:R:Y216	5.97	No	Yes	5	4	6
94	R:R:M173	R:R:Y216	8.38	No	Yes	5	6	6
95	R:R:V176	R:R:Y204	3.79	No	No	0	6	4
96	R:R:F208	R:R:V176	7.87	No	No	0	8	6
97	R:R:F208	R:R:P177	10.11	No	No	0	8	6
98	R:R:G180	R:R:W199	5.63	No	Yes	0	5	6
99	R:R:E185	R:R:R181	5.82	No	No	4	3	6
100	R:R:E185	R:R:V182	4.28	No	No	0	3	5
101	R:R:W184	R:R:W199	5.62	No	Yes	6	3	6
102	R:R:S200	R:R:W184	8.65	No	No	6	5	3
103	R:R:E323	R:R:S196	8.62	No	No	0	4	4
104	R:R:L197	R:R:Y303	4.69	No	Yes	7	6	7
105	R:R:H307	R:R:L197	9	No	No	7	6	6
106	R:R:Q198	R:R:V209	5.73	Yes	No	0	4	6
107	R:R:H307	R:R:Q198	12.36	No	Yes	0	6	4
108	R:R:Q198	R:R:V310	4.3	Yes	No	0	4	4
109	R:R:S200	R:R:W199	3.71	No	Yes	6	5	6
110	R:R:C205	R:R:W199	10.45	No	Yes	0	6	6
111	R:R:L207	R:R:Q206	3.99	No	No	0	3	4
112	R:R:A311	R:R:V209	5.09	No	No	0	6	6
113	R:R:F212	R:R:Y216	12.38	No	Yes	0	6	6
114	R:R:F212	R:R:F304	11.79	No	Yes	0	6	7
115	R:R:L215	R:R:Y216	7.03	No	Yes	0	5	6
116	R:R:F217	R:R:F296	5.36	No	Yes	0	8	9
117	R:R:F217	R:R:L301	7.31	No	No	0	8	6
118	R:R:F217	R:R:F304	12.86	No	Yes	0	8	7
119	R:R:L219	R:R:P220	4.93	No	No	0	5	9
120	R:R:L219	R:R:L223	4.15	No	No	0	5	6
121	R:R:F296	R:R:P220	5.78	Yes	No	0	9	9
122	R:R:L221	R:R:L297	5.54	No	No	0	6	5
123	R:R:I224	R:R:Y228	4.84	No	Yes	0	8	9
124	R:R:L289	R:R:Y228	4.69	No	Yes	0	8	9
125	R:R:V292	R:R:Y228	3.79	No	Yes	0	8	9
126	R:R:F232	R:R:R236	4.28	Yes	No	0	5	5
127	R:R:A285	R:R:F232	5.55	No	Yes	0	8	5
128	R:R:A286	R:R:F232	4.16	No	Yes	0	7	5
129	R:R:L344	R:R:V288	5.96	No	No	0	7	9
130	R:R:V292	R:R:Y341	3.79	No	No	0	8	9
131	R:R:F340	R:R:Q295	26.94	No	No	0	8	6
132	R:R:F296	R:R:W300	12.03	Yes	Yes	0	9	8
133	R:R:C299	R:R:W300	6.53	No	Yes	2	8	8
134	R:R:C299	R:R:C333	7.28	No	No	2	8	9
135	R:R:F304	R:R:W300	7.02	Yes	Yes	0	7	8
136	R:R:G330	R:R:W300	4.22	No	Yes	0	7	8
137	R:R:C333	R:R:W300	9.14	No	Yes	2	9	8
138	R:R:F304	R:R:Y303	9.28	Yes	Yes	0	7	7
139	R:R:H307	R:R:Y303	17.42	No	Yes	7	6	7
140	R:R:T327	R:R:Y303	7.49	No	Yes	0	6	7
141	R:R:F306	R:R:V310	7.87	Yes	No	0	5	4
142	R:R:F306	R:R:T319	9.08	Yes	No	8	5	5
143	R:R:F306	R:R:V322	10.49	Yes	No	8	5	5
144	R:R:F306	R:R:V326	3.93	Yes	No	0	5	5
145	R:R:T319	R:R:V322	4.76	No	No	8	5	5
146	R:R:E323	R:R:G320	4.91	No	No	0	4	1
147	R:R:Q321	R:R:V322	4.3	No	No	0	2	5
148	R:R:T327	R:R:Y331	6.24	No	Yes	0	6	8
149	R:R:W328	R:R:Y331	4.82	Yes	Yes	0	5	8
150	R:R:F334	R:R:Y331	6.19	Yes	Yes	0	9	8
151	R:R:F332	R:R:T335	5.19	No	No	0	4	6
152	R:R:C333	R:R:N337	6.3	No	Yes	2	9	9
153	R:R:N337	R:R:S336	4.47	Yes	No	0	9	5
154	R:R:F339	R:R:P338	5.78	No	No	0	6	9
155	R:R:I348	R:R:N345	11.33	Yes	No	3	8	9
156	R:R:R346	R:R:R349	10.66	No	No	0	7	9
157	R:R:K354	R:R:Q355	4.07	No	No	0	4	5
158	R:R:P177	R:R:V123	3.53	No	No	0	6	7
159	R:R:P302	R:R:V326	3.53	No	No	0	9	5
160	R:R:L119	R:R:Y118	3.52	No	Yes	1	5	6
161	R:R:P71	R:R:T70	3.5	No	No	0	6	6
162	R:R:E323	R:R:F306	3.5	No	Yes	0	4	5
163	R:R:C195	R:R:S100	3.44	No	No	0	9	5
164	R:R:A174	R:R:V123	3.39	No	No	0	8	7
165	R:R:A56	R:R:T335	3.36	No	No	0	7	6
166	R:R:C83	R:R:M64	3.24	No	Yes	0	9	7
167	R:R:P316	R:R:Q315	3.16	No	No	0	1	2
168	R:R:A170	R:R:L128	3.15	No	No	0	8	7
169	R:R:T335	R:R:T55	3.14	No	No	0	6	5
170	R:R:C205	R:R:Q198	3.05	No	Yes	0	6	4
171	R:R:L158	R:R:V162	2.98	No	No	0	6	6
172	R:R:L163	R:R:V159	2.98	No	No	0	7	7
173	R:R:M49	R:R:M98	2.89	No	No	0	6	6
174	R:R:Q295	R:R:S336	2.89	No	No	0	6	5
175	R:R:I348	R:R:L352	2.85	Yes	Yes	0	8	7
176	R:R:S230	R:R:Y141	2.54	No	Yes	0	5	8
177	R:R:S313	R:R:Y309	2.54	No	No	0	3	5
178	R:R:V227	R:R:Y228	2.52	No	Yes	0	5	9
179	R:R:F120	R:R:L171	2.44	Yes	No	0	6	3
180	R:R:F296	R:R:L221	2.44	Yes	No	0	9	6
181	R:R:F332	R:R:L298	2.44	No	No	0	4	4
182	R:R:L96	R:R:Y118	2.34	No	Yes	0	4	6
183	R:R:G293	R:R:G294	2.11	No	No	0	7	5
184	R:R:F306	R:R:Y309	2.06	Yes	No	0	5	5
185	R:R:A58	R:R:G59	1.95	No	No	0	3	9
186	R:R:A62	R:R:G59	1.95	No	No	0	7	9
187	R:R:A114	R:R:G111	1.95	No	No	0	4	8
188	R:R:P192	R:R:P193	1.95	No	No	0	3	3
189	R:R:G180	R:R:S183	1.86	No	No	0	5	4
190	R:R:G342	R:R:V79	1.84	No	No	0	7	8
191	R:R:G157	R:R:T155	1.82	No	No	0	4	8
192	R:R:A174	R:R:C124	1.81	No	No	0	8	5
193	R:R:A235	R:R:A285	1.79	No	No	0	8	8
194	R:R:C205	R:R:S202	1.72	No	No	0	6	3
195	R:R:G180	R:R:L179	1.71	No	No	0	5	4
196	R:R:G294	R:R:L297	1.71	No	No	0	5	5
197	R:R:A90	R:R:V57	1.7	No	No	0	7	6
198	R:R:I329	R:R:P302	1.69	No	No	0	7	9
199	R:R:A72	R:R:T70	1.68	No	No	0	5	6
200	R:R:M94	R:R:P95	1.68	No	No	0	7	9
201	R:R:S175	R:R:V176	1.62	No	No	0	5	6
202	R:R:S230	R:R:V226	1.62	No	No	0	5	4
203	R:R:A45	R:R:M49	1.61	No	No	0	5	6
204	R:R:A90	R:R:M94	1.61	No	No	0	7	7
205	R:R:V144	R:R:V145	1.6	No	No	0	8	6
206	R:R:V164	R:R:V168	1.6	No	No	0	2	3
207	R:R:V325	R:R:V326	1.6	No	No	0	4	5
208	R:R:C115	R:R:L119	1.59	No	No	1	9	5
209	R:R:C195	R:R:L119	1.59	No	No	1	9	5
210	R:R:C343	R:R:L352	1.59	No	Yes	0	5	7
211	R:R:A58	R:R:L54	1.58	No	No	0	3	4
212	R:R:A61	R:R:L87	1.58	No	No	0	4	7
213	R:R:A62	R:R:L352	1.58	No	Yes	0	7	7
214	R:R:A56	R:R:N60	1.56	No	Yes	0	7	9
215	R:R:H146	R:R:P147	1.53	No	No	0	6	9
216	R:R:H201	R:R:P316	1.53	No	No	0	5	1
217	R:R:M173	R:R:V211	1.52	No	No	0	6	3
218	R:R:A203	R:R:Q206	1.52	No	No	0	3	4
219	R:R:A314	R:R:Q315	1.52	No	No	0	3	2
220	R:R:I317	R:R:T319	1.52	No	No	0	1	5
221	R:R:L301	R:R:S305	1.5	No	No	0	6	5
222	R:R:G350	R:R:R349	1.5	No	No	0	5	9
223	R:R:L308	R:R:V210	1.49	No	No	0	5	5
224	R:R:L91	R:R:T92	1.47	No	No	0	4	5
225	R:R:D53	R:R:V57	1.46	No	No	0	7	6
226	R:R:Q315	R:R:S313	1.44	No	No	0	2	3
227	R:R:A213	R:R:F304	1.39	No	Yes	0	6	7
228	R:R:L96	R:R:L99	1.38	No	No	0	4	5
229	R:R:L221	R:R:L225	1.38	No	No	0	6	4
230	R:R:K69	R:R:Q355	1.36	No	No	0	6	5
231	R:R:E351	R:R:K354	1.35	No	No	0	8	4
232	R:R:S324	R:R:W328	1.24	No	Yes	0	5	5
233	R:R:F232	R:R:L289	1.22	Yes	No	0	5	8
234	R:R:F47	R:R:F48	1.07	No	No	0	4	4
235	R:R:R149	R:R:R153	1.07	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:N60	8.2525	4	0	9
2	R:R:M64	5.855	4	0	7
3	R:R:F76	7.044	5	3	9
4	R:R:F78	7.745	4	0	8
5	R:R:H81	7.3375	4	0	9
6	R:R:L82	7.395	4	2	9
7	R:R:D86	9.99	4	2	9
8	R:R:Y118	4.944	5	1	6
9	R:R:F120	4.1975	4	0	6
10	R:R:F125	6.75	4	0	7
11	R:R:Y141	7.8025	4	0	8
12	R:R:Q198	6.36	4	0	4
13	R:R:W199	6.3525	4	6	6
14	R:R:Y216	8.99143	7	5	6
15	R:R:Y228	4.402	5	0	9
16	R:R:F232	3.8025	4	0	5
17	R:R:F296	6.4025	4	0	9
18	R:R:W300	7.95714	7	2	8
19	R:R:Y303	9.72	4	7	7
20	R:R:F304	8.468	5	0	7
21	R:R:F306	6.155	6	8	5
22	R:R:W328	9.02333	6	0	5
23	R:R:Y331	6.865	6	1	8
24	R:R:F334	8.25	4	0	9
25	R:R:N337	7.8025	4	2	9
26	R:R:I348	5.9525	4	3	8
27	R:R:L352	2.995	4	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:M94	R:R:W328	13.0885	5.82	No	Yes	0	7	5
2	R:R:C83	R:R:N60	18.4532	6.3	No	Yes	0	9	9
3	R:R:D86	R:R:N60	33.4701	12.12	Yes	Yes	0	9	9
4	R:R:D86	R:R:F334	79.5876	14.33	Yes	Yes	0	9	9
5	R:R:F334	R:R:Y331	53.9748	6.19	Yes	Yes	0	9	8
6	R:R:W328	R:R:Y331	25.7462	4.82	Yes	Yes	0	5	8
7	R:R:C83	R:R:M64	14.4733	3.24	No	Yes	0	9	7
8	R:R:I348	R:R:L352	16.4735	2.85	Yes	Yes	0	8	7
9	R:R:I348	R:R:V79	50.6103	4.61	Yes	No	0	8	8
10	R:R:I136	R:R:V79	54.303	6.14	No	No	0	9	8
11	R:R:I136	R:R:L82	100	4.28	No	Yes	0	9	9
12	R:R:D86	R:R:L82	70.2944	5.43	Yes	Yes	2	9	9
13	R:R:E351	R:R:L73	16.812	3.98	No	No	0	8	8
14	R:R:F76	R:R:L73	19.0891	3.65	Yes	No	3	9	8
15	R:R:F76	R:R:I348	32.2289	5.02	Yes	Yes	3	9	8
16	R:R:L82	R:R:S132	36.3935	7.51	Yes	No	0	9	8
17	R:R:H81	R:R:S132	34.2291	8.37	Yes	No	0	9	8
18	R:R:H81	R:R:L163	18.4737	7.71	Yes	No	0	9	7
19	R:R:F78	R:R:L163	11.7858	3.65	Yes	No	0	8	7
20	R:R:D86	R:R:N337	13.8989	8.08	Yes	Yes	2	9	9
21	R:R:A89	R:R:F334	26.6284	8.32	No	Yes	0	7	9
22	R:R:F125	R:R:L93	23.5819	8.53	Yes	No	0	7	8
23	R:R:L93	R:R:Y331	23.028	12.89	No	Yes	1	8	8
24	R:R:R116	R:R:V178	14.2579	5.23	No	No	0	7	6
25	R:R:F120	R:R:V178	16.5761	3.93	Yes	No	0	6	6
26	R:R:F120	R:R:L121	38.2808	4.87	Yes	No	0	6	5
27	R:R:F125	R:R:L121	42.4249	4.87	Yes	No	0	7	5
28	R:R:Y118	R:R:Y331	15.8683	5.96	Yes	Yes	1	6	8
29	R:R:A174	R:R:F120	18.6173	5.55	No	Yes	0	8	6
30	R:R:F304	R:R:Y303	57.3495	9.28	Yes	Yes	0	7	7
31	R:R:T327	R:R:Y303	64.5502	7.49	No	Yes	0	6	7
32	R:R:T327	R:R:Y331	65.2375	6.24	No	Yes	0	6	8
33	R:R:F304	R:R:W300	43.1121	7.02	Yes	Yes	0	7	8
34	R:R:I130	R:R:W300	11.0781	9.4	No	Yes	0	8	8
35	R:R:I136	R:R:R140	57.6982	5.01	No	No	0	9	9
36	R:R:R140	R:R:Y228	52.6721	6.17	No	Yes	0	9	9
37	R:R:F217	R:R:F304	14.4425	12.86	No	Yes	0	8	7
38	R:R:F217	R:R:F296	11.8269	5.36	No	Yes	0	8	9
39	R:R:F296	R:R:P220	12.5859	5.78	Yes	No	0	9	9
40	R:R:F296	R:R:W300	25.059	12.03	Yes	Yes	0	9	8
41	R:R:V227	R:R:Y228	28.2593	2.52	No	Yes	0	5	9
42	R:R:V227	R:R:Y141	25.9924	10.09	No	Yes	0	5	8
43	R:R:V145	R:R:Y141	16.8428	12.62	No	Yes	0	6	8
44	R:R:A174	R:R:V123	14.022	3.39	No	No	0	8	7
45	R:R:P177	R:R:V123	11.6832	3.53	No	No	0	6	7
46	R:R:C205	R:R:W199	17.212	10.45	No	Yes	0	6	6
47	R:R:C205	R:R:Q198	22.8023	3.05	No	Yes	0	6	4
48	R:R:H307	R:R:Q198	77.0028	12.36	No	Yes	0	6	4
49	R:R:H307	R:R:Y303	78.8183	17.42	No	Yes	7	6	7
50	R:R:Q198	R:R:V310	50.5385	4.3	Yes	No	0	4	4
51	R:R:F296	R:R:L221	15.6837	2.44	Yes	No	0	9	6
52	R:R:L289	R:R:Y228	14.5143	4.69	No	Yes	0	8	9
53	R:R:F232	R:R:L289	12.1243	1.22	Yes	No	0	5	8
54	R:R:C333	R:R:N337	61.0627	6.3	No	Yes	2	9	9
55	R:R:F306	R:R:V310	48.0049	7.87	Yes	No	0	5	4
56	R:R:F306	R:R:V326	11.4986	3.93	Yes	No	0	5	5
57	R:R:A56	R:R:N60	10.4524	1.56	No	Yes	0	7	9
58	R:R:F306	R:R:Y309	17.2223	2.06	Yes	No	0	5	5
59	R:R:S313	R:R:Y309	14.4015	2.54	No	No	0	3	5
60	R:R:Q315	R:R:S313	11.5602	1.44	No	No	0	2	3
61	R:R:A89	R:R:F125	24.9359	9.71	No	Yes	0	7	7
62	R:R:C333	R:R:W300	58.8471	9.14	No	Yes	2	9	8
63	R:R:L82	R:R:N337	50.0667	12.36	Yes	Yes	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8KGK_nogp

PDB Summary
PDB	8KGK_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.56
Number of Linked Nodes	224
Number of Links	235
Number of Hubs	27
Number of Links mediated by Hubs	111
Number of Communities	8
Number of Nodes involved in Communities	33
Number of Links involved in Communities	37

Path Summary
Number Of Nodes in MetaPath	64
Number Of Links MetaPath	63
Number of Shortest Paths	24344
Length Of Smallest Path	3
Average Path Length	11.5536
Length of Longest Path	24
Minimum Path Strength	1.48
Average Path Strength	7.03553
Maximum Path Strength	17.53
Minimum Path Correlation	0.7
Average Path Correlation	0.907495
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.26316
Average % Of Corr. Nodes	47.3234
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.2712
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component	• protein-containing complex • receptor complex • endosome membrane • membrane-bounded organelle • intracellular anatomical structure • membrane • endosome • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle membrane • cellular anatomical structure • bounding membrane of organelle • vesicle membrane • cytoplasmic vesicle • organelle • cytoplasm • vesicle • organelle membrane • cell periphery • plasma membrane • protein-containing complex binding • binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • protein binding • signaling receptor binding • G protein-coupled receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • metal ion binding • D1 dopamine receptor binding • dopamine receptor binding • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • response to amine • response to chemical • response to nitrogen compound • response to amphetamine • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to purine-containing compound • response to caffeine • response to alkaloid • developmental process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • cellular homeostasis • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • neuromuscular process • regulation of system process • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • regulation of multicellular organismal process • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • cellular response to endogenous stimulus • response to hormone • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • positive regulation of biological process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • positive regulation of cell communication • regulation of localization • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • localization • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular response to carbohydrate stimulus • response to glucose • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • signal release • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • positive regulation of cellular process • positive regulation of peptide secretion • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • peptide transport • response to hexose • positive regulation of transport • regulation of cellular localization • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • regulation of insulin secretion involved in cellular response to glucose stimulus • hormone transport • regulation of cell communication • insulin secretion • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • serotonin receptor signaling pathway • adenylate cyclase-activating serotonin receptor signaling pathway • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • cell surface receptor signaling pathway • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cell population proliferation • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9BZJ8
Sequence	>8KGK_nogp_Chain_R S V A L F F M L L L D L T A V A G N A A V M A V I A K T P A L R K F V F V F H L C L V D L L A A L T L M P L A M L S S S A G E V A C R L Y L F L S V C F V S L A I L S V S A I N V E R Y Y Y V V H P M R Y E V R M T L G L V A S V L V G V W V K A L A M A S V P V L G R V S W E P P G C S L Q W S H S A Y C Q L F V V V F A V L Y F L L P L L L I L V V Y C S M F R V A R V A G K A A V V L L A V G G Q F L L C W L P Y F S F H L Y V A L S A Q P I S T G Q V E S V V T W I G Y F C F T S N P F F Y G C L N R Q I R G E L S K Q Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8TB0	A	Orphan	Orphan	GPR61	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.47	2023-10-04	doi.org/10.1038/s41467-023-41646-3
	8TB0 (No Gprot)	A	Orphan	Orphan	GPR61	Homo sapiens	-	-		3.47	2023-10-04	doi.org/10.1038/s41467-023-41646-3
	8TB7	A	Orphan	Orphan	GPR61	Homo sapiens	-	PubChem 168510218	-	2.94	2023-10-04	doi.org/10.1038/s41467-023-41646-3
	8KGK	A	Orphan	Orphan	GPR61	Homo sapiens	-	-	Gs/β1/γ2	3.16	2023-10-11	doi.org/10.1038/s41467-023-41654-3
	8KGK (No Gprot)	A	Orphan	Orphan	GPR61	Homo sapiens	-	-		3.16	2023-10-11	doi.org/10.1038/s41467-023-41654-3

there is no ligand in network 8KGK_nogp

Data downloads are temporarily suspended for technical reasons. We apologize for the inconvenience.

Data downloads are temporarily suspended for technical reasons.
We apologize for the inconvenience.