Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:N60 7.1025439
2R:R:T70 4.43254206
3R:R:L73 4.6354208
4R:R:F78 7.4675408
5R:R:H81 6.69754179
6R:R:F110 4.82754215
7R:R:R116 4.4554217
8R:R:F120 2.584506
9R:R:L121 2.7325405
10R:R:I136 4.355439
11R:R:N137 5.8825408
12R:R:R140 6.028539
13R:R:Y143 9.17408
14R:R:P177 3.97466
15R:R:Q198 4.4375464
16R:R:W199 7.198566
17R:R:F212 4.2275406
18R:R:Y216 4.755606
19R:R:L223 4.0525406
20R:R:Y228 4.882509
21R:R:Q295 5.00833636
22R:R:F296 5.838509
23R:R:W300 5.22143738
24R:R:F306 6.244565
25R:R:H307 6.95466
26R:R:E323 7.8075464
27R:R:W328 7.3485155
28R:R:Y331 6.9685158
29R:R:C333 4.778539
30R:R:F334 4.486539
31R:R:S336 3.955435
32R:R:N337 5.4475439
33R:R:Y341 5.92333639
34R:R:N345 5.8875439
35A:A:H41 4.596596
36A:A:L44 5.616519
37A:A:L46 2.9625418
38A:A:F208 3.11575
39A:A:V214 3.4825496
40A:A:F219 6.194598
41A:A:Q227 4.332579
42A:A:K233 5.95754169
43A:A:W234 4.66509
44A:A:C237 4.565418
45A:A:F238 7.66519
46A:A:F246 3.614519
47A:A:L272 4.86418
48A:A:F273 6.465419
49A:A:W277 8.244516
50A:A:I288 3.892589
51A:A:L289 3.138519
52A:A:L291 3.4325418
53A:A:N292 6.346589
54A:A:K307 9.99254246
55A:A:I308 5.4054247
56A:A:F315 5.6575406
57A:A:Y339 4.694513
58A:A:F340 6.9285257
59A:A:I341 4.0225408
60A:A:R342 4.71833614
61A:A:F345 3.98833618
62A:A:S349 4.42417
63A:A:R356 5.506502
64A:A:Y360 5.736588
65A:A:T364 7.015489
66A:A:F376 5.2325498
67A:A:Y391 5.63434
68A:A:L393 3.6375408
69B:B:R22 5.93406
70B:B:V40 4.0545263
71B:B:L51 6.9775429
72B:B:H54 5.28167629
73B:B:K57 8.935419
74B:B:Y59 9.2875418
75B:B:W63 5.87607
76B:B:V71 3.5465128
77B:B:Q75 9.1275419
78B:B:D76 7.7775409
79B:B:L79 5.186127
80B:B:I81 4.2075407
81B:B:W82 7.49857729
82B:B:Y85 10.52424
83B:B:N88 5.45754237
84B:B:K89 8.296529
85B:B:I93 6.775407
86B:B:W99 10.692519
87B:B:C103 4.374128
88B:B:Y105 3.843336126
89B:B:N110 4.4354134
90B:B:Y111 8.2885134
91B:B:V112 3.2954128
92B:B:N119 3.285479
93B:B:Y124 6.7125406
94B:B:H142 6.51579
95B:B:Y145 4.5575408
96B:B:C149 3.385408
97B:B:R150 3.0625406
98B:B:F151 4.34509
99B:B:L152 4.194543
100B:B:I157 4.3725407
101B:B:T159 5.4575409
102B:B:D163 7.128579
103B:B:W169 7.686578
104B:B:T173 3.65754185
105B:B:Q176 7.0625474
106B:B:F180 7.884547
107B:B:H183 6.27749
108B:B:L190 4.3775445
109B:B:L192 3.3175445
110B:B:F199 6.36167649
111B:B:V200 6.2025456
112B:B:S201 4.565449
113B:B:D205 6.466549
114B:B:K209 13.0375446
115B:B:L210 5.73555
116B:B:W211 8.24167648
117B:B:Q220 6.028557
118B:B:F222 5.57333658
119B:B:H225 8.0725859
120B:B:I229 5.1775457
121B:B:I232 4.3225458
122B:B:F235 6.675717146
123B:B:F241 5.66143756
124B:B:T243 4.42833658
125B:B:D246 5.42754169
126B:B:D247 3.83459
127B:B:T249 3.7075456
128B:B:R251 14.5125458
129B:B:F253 7.91167656
130B:B:D254 4.175409
131B:B:D258 8.515457
132B:B:Q259 4.1675406
133B:B:Y264 5.20754105
134B:B:I269 3.7485104
135B:B:F278 3.945147
136B:B:R283 8.54754269
137B:B:L284 3.1675405
138B:B:L285 3.835406
139B:B:Y289 7.311437107
140B:B:N293 3.1875405
141B:B:V296 3.8125405
142B:B:W297 6.2985108
143B:B:K301 4.2325405
144B:B:R304 6.6975405
145B:B:H311 5.4456119
146B:B:R314 11.092518
147B:B:W332 11.9467619
148B:B:D333 6.264119
149B:B:L336 3.9175427
150B:B:K337 6.9556116
151B:B:I338 4.29425
152B:B:W339 8.51754119
153G:G:Y40 8.924146
154G:G:D48 5.776279
155G:G:L50 3.25254279
156G:G:L51 4.18406
157G:G:N59 6.125429
158G:G:P60 7.0425429
159G:G:F61 5.04889928
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:D86 R:R:F334 12.17867.17NoYes399
2R:R:A89 R:R:F334 43.06584.16NoYes079
3R:R:A89 R:R:F125 42.12975.55NoNo077
4R:R:C124 R:R:F125 40.25764.19NoNo057
5R:R:C124 R:R:F120 39.32172.79NoYes056
6R:R:F120 R:R:L121 26.21972.44YesYes065
7R:R:L121 R:R:L93 14.05142.77YesNo058
8R:R:L93 R:R:Y331 13.11589.38NoYes088
9R:R:W328 R:R:Y331 14.05110.61YesYes1558
10R:R:Q295 R:R:Y341 68.62973.38YesYes369
11R:R:F296 R:R:Q295 44.30093.51YesYes096
12R:R:F217 R:R:F296 20.59535.36NoYes089
13R:R:F217 R:R:F304 19.347210.72NoNo087
14R:R:F212 R:R:F304 18.72396.43YesNo067
15R:R:F212 R:R:V123 16.5542.62YesNo067
16R:R:Q198 R:R:V123 15.93044.3YesNo047
17R:R:H307 R:R:Q198 12.80997.42YesYes664
18R:R:F296 R:R:W300 22.15296.01YesYes098
19R:R:F334 R:R:W300 57.1033.01YesYes398
20R:R:C333 R:R:Q295 22.77276.1YesYes396
21R:R:C333 R:R:W300 44.3023.92YesYes398
22R:R:N337 R:R:Y341 23.08374.65YesYes399
23R:R:C333 R:R:N337 22.77593.15YesYes399
24R:R:R140 R:R:Y341 1007.2YesYes399
25A:A:Y391 R:R:R140 1008.23YesYes349
26A:A:Y391 R:R:Y143 1005.96YesYes048
27R:R:L117 R:R:L121 10.30312.77NoYes035
28R:R:F120 R:R:V178 10.30453.93YesNo066
29R:R:N137 R:R:Y341 11.930311.63YesYes089
30A:A:H387 R:R:Y143 10014.16NoYes088
31A:A:H387 R:R:P147 1004.58NoNo089
32A:A:Q384 R:R:P147 1006.32NoNo069
33A:A:F376 A:A:N377 1002.42YesNo084
34A:A:N377 A:A:R380 1002.41NoNo047
35A:A:Q384 A:A:R380 1003.5NoNo067
36A:A:F219 A:A:L43 65.56873.65YesNo087
37A:A:F219 A:A:V214 1002.62YesYes986
38A:A:F376 A:A:V214 1003.93YesYes986
39A:A:F208 B:B:N119 36.7672.42YesYes759
40A:A:F208 A:A:I207 1003.77YesNo059
41A:A:D223 A:A:I207 1002.8NoNo099
42A:A:D223 A:A:E50 68.72326.5NoNo099
43A:A:E50 A:A:L45 68.650821.2NoNo098
44A:A:L45 A:A:M221 1004.24NoNo088
45A:A:L43 A:A:M221 71.38315.65NoNo078
46A:A:D223 A:A:N54 68.878716.16NoNo099
47A:A:L45 A:A:N54 68.66134.12NoNo089
48A:A:F212 A:A:M221 65.62884.98NoNo098
49A:A:F212 A:A:F219 65.475812.86NoYes098
50B:B:H54 B:B:W82 33.41513.17YesYes299
51B:B:H54 B:B:S74 98.51256.97YesNo099
52B:B:D76 B:B:S74 98.541810.31YesNo099
53B:B:D76 B:B:L55 10012.21YesNo096
54A:A:Y37 B:B:L55 1005.86NoNo046
55A:A:R42 A:A:Y37 1009.26NoNo094
56A:A:F222 A:A:R42 1004.28NoNo079
57A:A:F222 B:B:W99 10022.05NoYes079
58A:A:F238 B:B:W99 10011.02YesYes199
59A:A:F238 A:A:L44 33.919810.96YesYes199
60A:A:L44 A:A:V224 32.8542.98YesNo099
61A:A:G225 A:A:V224 67.09173.68NoNo099
62A:A:F208 A:A:G225 67.01323.01YesNo059
63B:B:I80 B:B:W82 33.414911.74NoYes289
64B:B:I80 B:B:K78 33.45432.91NoNo088
65B:B:D76 B:B:K78 33.53396.91YesNo098
66A:A:F238 A:A:W234 99.04394.01YesYes099
67A:A:V224 A:A:W234 34.26788.58NoYes099
68A:A:Q227 A:A:W234 69.08083.29YesYes099
69A:A:A226 A:A:Q227 34.37824.55NoYes799
70A:A:A226 A:A:F208 34.36812.77NoYes795
71A:A:Q227 B:B:N119 34.37692.64YesYes799
72A:A:I276 A:A:L46 10.96562.85NoYes188
73A:A:F246 A:A:I276 10.88692.51YesNo198
74A:A:F246 A:A:L289 13.30962.44YesYes199
75B:B:I18 G:G:L19 11.07251.43NoNo079
76B:B:I18 B:B:R22 15.50115.01NoYes076
77B:B:D258 B:B:R22 30.999911.91YesYes076
78B:B:D258 B:B:F222 33.21067.17YesYes578
79B:B:F222 B:B:F241 18.81836.43YesYes586
80B:B:F241 B:B:T243 33.76042.59YesYes568
81B:B:G244 B:B:T243 73.05031.82NoYes058
82B:B:G244 B:B:I273 73.60293.53NoNo056
83B:B:I273 B:B:Y289 74.15559.67NoYes067
84B:B:W297 B:B:Y289 82.421712.54YesYes1087
85B:B:W297 B:B:Y264 1006.75YesYes1085
86B:B:L285 B:B:Y264 1004.69YesYes065
87B:B:F278 B:B:L285 1006.09YesYes076
88B:B:F235 B:B:F278 1006.43YesYes1467
89B:B:F235 G:G:C41 1004.19YesNo067
90B:B:L300 G:G:C41 1004.76NoNo067
91B:B:L300 B:B:R283 10010.93NoYes069
92B:B:R283 B:B:V40 39.99016.54YesYes2693
93B:B:V40 G:G:L51 41.45922.98YesYes036
94G:G:D48 G:G:L51 83.27859.5YesYes096
95G:G:D48 G:G:P49 1004.83YesNo097
96B:B:M325 G:G:P49 1003.35NoNo057
97B:B:M325 G:G:P60 1003.35NoYes059
98G:G:F61 G:G:P60 1005.78YesYes289
99B:B:I338 G:G:F61 1003.77YesYes258
100B:B:I338 B:B:L51 64.90574.28YesYes259
101B:B:L51 B:B:W82 65.078113.67YesYes299
102B:B:F222 B:B:F253 18.8216.43YesYes586
103B:B:F253 B:B:T243 22.13729.08YesYes568
104B:B:L284 B:B:R283 79.9912.43YesYes059
105B:B:L284 G:G:L51 41.27492.77YesYes056
106B:B:L284 B:B:S279 41.27613YesNo059
107B:B:S279 G:G:D48 41.45495.89NoYes2799
108B:B:I338 B:B:L336 64.87332.85YesYes257
109B:B:I58 B:B:L336 32.47974.28NoYes097
110B:B:H54 B:B:I58 32.52027.95YesNo099
111B:B:L336 B:B:S72 32.47983YesNo279
112B:B:H54 B:B:S72 32.52015.58YesNo299
113B:B:L198 B:B:L210 11.62734.15NoYes035
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8TB0
Class A
SubFamily Orphan
Type A orphans
SubType GPR61
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 3.47
Date 2023-10-04
D.O.I. 10.1038/s41467-023-41646-3
Net Summary
Imin 2.41
Number of Linked Nodes 799
Number of Links 971
Number of Hubs 159
Number of Links mediated by Hubs 581
Number of Communities 28
Number of Nodes involved in Communities 237
Number of Links involved in Communities 341
Path Summary
Number Of Nodes in MetaPath 114
Number Of Links MetaPath 113
Number of Shortest Paths 25239448
Length Of Smallest Path 3
Average Path Length 74.4707
Length of Longest Path 84
Minimum Path Strength 1.1
Average Path Strength 8.01576
Maximum Path Strength 20.695
Minimum Path Correlation 0.7
Average Path Correlation 1
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.69492
Average % Of Corr. Nodes 41.0747
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 67.2177
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ9BZJ8
Sequence
>8TB0_Chain_R
ALFFMLLLD LTAVAGNAA VMAVIAKTP ALRKFVFVF HLCLVDLLA 
ALTLMPLAM LSSSALFDH ALFGEVACR LYLFLSVCF VSLAILSVS 
AINVERYYY VVHPMRYEV RMTLGLVAS VLVGVWVKA LAMASVPVL 
GGCSLQWSH SAYCQLFVV VFAVLYFLL PLLLILVVY CSMFRVARV 
AGKAAVVLL AVGGQFLLC WLPYFSFHL YVALSAQPI STGQVESVV 
TWIGYFCFT SNPFFYGCL NRQIRGELS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8TB0_Chain_A
LSAEDKAAV ERSKMIEKQ LQKDKQVYR ATHRLLLLG AGESGKNTI 
VKQIFETKF QVDKVNFHM FDVGAQRDE RRKWIQCFN DVTAIIFVV 
ASSSTNRLQ AALKLFDSI WNNKWLRDT SVILFLNKQ DLLAEKVLA 
GKIEDYFPE FARYTTPED ATPEPGEDP RVTRAKYFI RDEFLRIST 
ASGDGRHYC YPHFTCDTE NIRRVFNDC RDIIQRMHL RQYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8TB0_Chain_B
RQEAEQLKN QIRDARKAC ADATLSQIT NNIDPVGRI QMRTRRTLR 
GHLAKIYAM HWGTDSRLL VSASQDGKL IIWDSYTTN KVHAIPLRS 
SWVMTCAYA PSGNYVACG GLDNICSIY NLKTREGNV RVSRELAGH 
TGYLSCCRF LDDNQIVTS SGDTTCALW DIETGQQTT TFTGHTGDV 
MSLSLAPDT RLFVSGACD ASAKLWDVR EGMCRQTFT GHESDINAI 
CFFPNGNAF ATGSDDATC RLFDLRADQ ELMTYSHDN IICGITSVS 
FSKSGRLLL AGYDDFNCN VWDALKADR AGVLAGHDN RVSCLGVTD 
DGMAVATGS WDSFLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8TB0_Chain_G
ARKLVEQLK MEANIDRIK VSKAAADLM AYCEAHAKE DPLLTPVPA 
SENPF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8KGKAOrphanA orphansGPR61Homo sapiens--Gs/&β;1/&γ;23.162023-10-1110.1038/s41467-023-41654-3
8TB0AOrphanA orphansGPR61Homo sapiens--chim(NtGi1-Gs)/&β;1/&γ;23.472023-10-0410.1038/s41467-023-41646-3
8TB7AOrphanA orphansGPR61Homo sapiens-PubChem 168510218-2.942023-10-0410.1038/s41467-023-41646-3




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8TB0.zip



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