Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:H41 4.596596
2A:A:L44 5.616519
3A:A:L45 6.99754208
4A:A:L46 2.9625418
5A:A:F208 3.11575
6A:A:V214 3.4825496
7A:A:F219 6.194598
8A:A:M221 5.51408
9A:A:Q227 4.332579
10A:A:K233 5.95754159
11A:A:W234 4.66509
12A:A:C237 4.565418
13A:A:F238 7.66519
14A:A:F246 3.614519
15A:A:V247 5.3725407
16A:A:L272 4.86418
17A:A:F273 6.465419
18A:A:W277 8.244516
19A:A:I288 3.892589
20A:A:L289 3.138519
21A:A:L291 3.4325418
22A:A:N292 6.346589
23A:A:F315 5.6575406
24A:A:Y339 4.694513
25A:A:F340 6.9285217
26A:A:I341 4.0225408
27A:A:R342 4.71833614
28A:A:F345 3.98833618
29A:A:S349 4.42417
30A:A:R356 4.552502
31A:A:Y360 5.736588
32A:A:T364 7.015489
33A:A:F376 5.2325498
34A:A:Y391 5.63454
35A:A:L393 3.6375408
36B:B:R22 5.93406
37B:B:V40 4.0545223
38B:B:L51 6.9775429
39B:B:H54 5.28167629
40B:B:K57 8.2425419
41B:B:Y59 9.2875418
42B:B:W63 5.87607
43B:B:V71 3.5465128
44B:B:Q75 9.1275419
45B:B:D76 7.7775409
46B:B:L79 5.186127
47B:B:I81 4.2075407
48B:B:W82 7.49857729
49B:B:Y85 10.52424
50B:B:N88 5.45754197
51B:B:K89 8.296529
52B:B:I93 6.775407
53B:B:W99 10.692519
54B:B:C103 4.374128
55B:B:Y105 3.843336126
56B:B:N110 4.4354134
57B:B:Y111 8.2885134
58B:B:V112 3.2954128
59B:B:N119 3.285479
60B:B:Y124 6.7125406
61B:B:H142 6.51579
62B:B:Y145 4.5575408
63B:B:C149 3.385408
64B:B:R150 3.0625406
65B:B:F151 4.34509
66B:B:L152 4.194533
67B:B:I157 4.3725407
68B:B:T159 5.4575409
69B:B:D163 7.128579
70B:B:W169 7.686578
71B:B:T173 3.65754175
72B:B:Q176 7.0625474
73B:B:F180 7.884537
74B:B:H183 6.27739
75B:B:L190 4.3775435
76B:B:L192 3.3175435
77B:B:F199 6.36167639
78B:B:V200 6.2025446
79B:B:S201 4.565439
80B:B:D205 6.466539
81B:B:K209 13.0375436
82B:B:L210 5.73545
83B:B:W211 8.24167638
84B:B:Q220 6.028547
85B:B:F222 5.57333648
86B:B:H225 8.0725849
87B:B:I229 5.1775447
88B:B:I232 4.3225448
89B:B:F235 6.675717146
90B:B:F241 5.66143746
91B:B:T243 4.42833648
92B:B:D246 5.42754159
93B:B:D247 3.83449
94B:B:T249 3.7075446
95B:B:R251 14.5125448
96B:B:F253 7.91167646
97B:B:D254 4.175409
98B:B:D258 8.515447
99B:B:Q259 4.1675406
100B:B:Y264 5.20754105
101B:B:I269 3.7485104
102B:B:F278 3.945147
103B:B:R283 8.54754229
104B:B:L284 3.1675405
105B:B:L285 3.835406
106B:B:Y289 7.311437107
107B:B:N293 3.1875405
108B:B:V296 3.8125405
109B:B:W297 6.2985108
110B:B:K301 4.2325405
111B:B:R304 6.6975405
112B:B:H311 5.4456119
113B:B:R314 11.092518
114B:B:W332 11.9467619
115B:B:D333 6.264119
116B:B:L336 3.9175427
117B:B:K337 6.9556116
118B:B:I338 4.29425
119B:B:W339 8.51754119
120G:G:Y40 8.924146
121G:G:D48 5.776239
122G:G:L50 3.25254239
123G:G:L51 4.18406
124G:G:N59 6.125429
125G:G:P60 7.0425429
126G:G:F61 5.04889928
127R:R:N60 7.1025459
128R:R:T70 4.43254256
129R:R:L73 4.6354258
130R:R:F78 7.4675408
131R:R:H81 6.69754189
132R:R:F110 4.82754265
133R:R:R116 4.4554267
134R:R:F120 2.584506
135R:R:L121 2.7325405
136R:R:I136 4.355459
137R:R:N137 5.8825408
138R:R:R140 6.028559
139R:R:Y143 9.17408
140R:R:P177 3.97466
141R:R:Q198 4.4375464
142R:R:W199 7.198566
143R:R:F212 4.2275406
144R:R:Y216 4.755606
145R:R:L223 4.0525406
146R:R:Y228 4.882509
147R:R:Q295 5.00833656
148R:R:F296 5.838509
149R:R:W300 5.22143758
150R:R:F306 6.244565
151R:R:H307 6.95466
152R:R:E323 7.8075464
153R:R:W328 7.3485165
154R:R:Y331 6.9685168
155R:R:C333 4.778559
156R:R:F334 4.486559
157R:R:S336 3.955455
158R:R:N337 5.4475459
159R:R:Y341 5.92333659
160R:R:N345 5.8875459
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:L51 B:B:W82 49.318513.67YesYes299
2B:B:I338 B:B:L51 49.18964.28YesYes259
3B:B:I338 G:G:F61 98.07533.77YesYes258
4B:B:I80 B:B:K78 25.35622.91NoNo088
5B:B:I80 B:B:W82 25.327711.74NoYes289
6B:B:H54 B:B:W82 25.32783.17YesYes299
7B:B:H54 B:B:S74 74.64416.97YesNo099
8B:B:D76 B:B:S74 74.662510.31YesNo099
9B:B:D76 B:B:L55 10012.21YesNo096
10B:B:I338 B:B:L336 49.15732.85YesYes257
11B:B:I58 B:B:L336 24.61084.28NoYes097
12B:B:H54 B:B:I58 24.64057.95YesNo099
13B:B:L336 B:B:S72 24.61093YesNo279
14B:B:H54 B:B:S72 24.64045.58YesNo299
15B:B:D76 B:B:K78 25.4146.91YesNo098
16A:A:Y37 B:B:L55 1005.86NoNo046
17A:A:R42 A:A:Y37 1009.26NoNo094
18A:A:F219 A:A:L43 65.1623.65YesNo087
19A:A:L43 A:A:M221 32.63355.65NoYes078
20A:A:L45 A:A:M221 65.41149.9YesYes088
21A:A:L45 A:A:N54 99.11484.12YesNo2089
22A:A:D223 A:A:N54 10016.16NoNo099
23A:A:D223 A:A:I207 1002.8NoNo099
24A:A:F208 A:A:I207 1003.77YesNo059
25A:A:F208 B:B:N119 27.22682.42YesYes759
26A:A:F212 A:A:F219 32.558512.86NoYes098
27A:A:F212 A:A:M221 32.63344.98NoYes098
28A:A:I245 A:A:L43 32.68134.28NoNo077
29A:A:I245 A:A:L45 33.71019.99NoYes078
30A:A:F222 A:A:R42 1004.28NoNo079
31A:A:F222 B:B:W99 10022.05NoYes079
32A:A:F238 B:B:W99 99.803511.02YesYes199
33A:A:F238 A:A:L44 25.771110.96YesYes199
34A:A:F238 A:A:W234 74.69724.01YesYes099
35A:A:L44 A:A:V224 24.3682.98YesNo099
36A:A:V224 A:A:W234 25.38328.58NoYes099
37A:A:F208 A:A:G225 49.63273.01YesNo059
38A:A:G225 A:A:V224 49.71853.68NoNo099
39A:A:A226 A:A:Q227 25.45084.55NoYes799
40A:A:F219 A:A:V214 96.10052.62YesYes986
41A:A:F376 A:A:V214 94.94963.93YesYes986
42A:A:F246 A:A:L289 11.13712.44YesYes199
43A:A:F376 A:A:N377 94.73442.42YesNo084
44A:A:N377 A:A:R380 94.50462.41NoNo047
45A:A:Q384 A:A:R380 94.04513.5NoNo067
46A:A:Q384 R:R:P147 93.81526.32NoNo069
47A:A:H387 R:R:P147 93.35564.58NoNo089
48A:A:H387 R:R:Y143 93.125814.16NoYes088
49A:A:Y391 R:R:Y143 88.52645.96YesYes048
50A:A:Y391 R:R:R140 81.79658.23YesYes549
51B:B:M325 G:G:P60 97.46983.35NoYes059
52B:B:M325 G:G:P49 97.33333.35NoNo057
53G:G:D48 G:G:P49 96.63824.83YesNo097
54B:B:S279 G:G:D48 31.2365.89NoYes2399
55B:B:L284 B:B:S279 31.10073YesNo059
56B:B:L284 B:B:R283 61.09012.43YesYes059
57B:B:L300 B:B:R283 91.216610.93NoYes069
58B:B:L300 G:G:C41 89.11144.76NoNo067
59B:B:F235 G:G:C41 88.69034.19YesNo067
60B:B:F235 B:B:F278 81.10776.43YesYes1467
61B:B:F278 B:B:L285 79.8466.09YesYes076
62B:B:L285 B:B:Y264 78.16064.69YesYes065
63B:B:W297 B:B:Y264 76.89536.75YesYes1085
64B:B:W297 B:B:Y289 62.956112.54YesYes1087
65B:B:I273 B:B:Y289 56.64959.67NoYes067
66B:B:G244 B:B:I273 56.22763.53NoNo056
67B:B:G244 B:B:T243 55.80561.82NoYes058
68B:B:F241 B:B:T243 25.79122.59YesYes468
69B:B:F222 B:B:F241 14.37656.43YesYes486
70B:B:D258 B:B:F222 25.37217.17YesYes478
71B:B:D258 B:B:R22 23.683911.91YesYes076
72B:B:I18 B:B:R22 11.84315.01NoYes076
73G:G:D48 G:G:L51 63.17579.5YesYes096
74B:B:L284 G:G:L51 31.09952.77YesYes056
75B:B:V40 G:G:L51 31.66242.98YesYes036
76B:B:R283 B:B:V40 30.54176.54YesYes2293
77B:B:F253 B:B:T243 16.91159.08YesYes468
78B:B:F222 B:B:F253 14.37926.43YesYes486
79R:R:R140 R:R:Y341 77.64297.2YesYes599
80R:R:Q295 R:R:Y341 51.21593.38YesYes569
81R:R:F296 R:R:Q295 33.06113.51YesYes096
82R:R:F217 R:R:F296 15.37115.36NoYes089
83R:R:F217 R:R:F304 14.439610.72NoNo087
84R:R:F212 R:R:F304 13.97466.43YesNo067
85R:R:F212 R:R:V123 12.35882.62YesNo067
86R:R:Q198 R:R:V123 11.89354.3YesNo047
87R:R:W328 R:R:Y331 10.489110.61YesYes1658
88R:R:F296 R:R:W300 16.53316.01YesYes098
89R:R:F334 R:R:W300 42.61773.01YesYes598
90R:R:A89 R:R:F334 32.14244.16NoYes079
91R:R:A89 R:R:F125 31.44375.55NoNo077
92R:R:C124 R:R:F125 30.04664.19NoNo057
93R:R:C124 R:R:F120 29.34822.79NoYes056
94R:R:F120 R:R:L121 19.57072.44YesYes065
95R:R:L121 R:R:L93 10.48952.77YesNo058
96R:R:C333 R:R:Q295 16.99456.1YesYes596
97R:R:C333 R:R:W300 33.06233.92YesYes598
98R:R:N337 R:R:Y341 17.22644.65YesYes599
99R:R:C333 R:R:N337 16.99773.15YesYes599
100A:A:A226 A:A:F208 25.43812.77NoYes795
101A:A:Q227 A:A:W234 51.29793.29YesYes099
102A:A:Q227 B:B:N119 25.44942.64YesYes799
103G:G:F61 G:G:P60 96.26615.78YesYes289
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8TB0
Class A
SubFamily Orphan
Type Orphan
SubType GPR61
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 3.47
Date 2023-10-04
D.O.I. doi.org/10.1038/s41467-023-41646-3
Net Summary
Imin 2.41
Number of Linked Nodes 798
Number of Links 969
Number of Hubs 160
Number of Links mediated by Hubs 585
Number of Communities 27
Number of Nodes involved in Communities 234
Number of Links involved in Communities 338
Path Summary
Number Of Nodes in MetaPath 104
Number Of Links MetaPath 103
Number of Shortest Paths 19172673
Length Of Smallest Path 3
Average Path Length 64.2859
Length of Longest Path 84
Minimum Path Strength 1.1
Average Path Strength 8.00003
Maximum Path Strength 20.695
Minimum Path Correlation 0.7
Average Path Correlation 1
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.69492
Average % Of Corr. Nodes 33.2071
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 64.0294
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • synapse   • cell junction   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • tetrapyrrole binding   • heme binding   • electron transfer activity   • cation binding   • transition metal ion binding   • iron ion binding   • ion binding   • metal ion binding   • small molecule binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • D1 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • molecular function regulator activity   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • arrestin family protein binding   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • electron transport chain   • metabolic process   • generation of precursor metabolites and energy   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • sensory perception of smell   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to glucagon   • cellular response to glucagon stimulus   • skeletal system development   • bone development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • regulation of metabolic process   • positive regulation of cellular process   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • localization   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of signaling   • regulation of transport   • secretion   • regulation of hormone levels   • regulation of peptide transport   • regulation of establishment of protein localization   • establishment of protein localization to extracellular region   • export from cell   • regulation of protein transport   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • cellular localization   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • signal transduction in absence of ligand   • ligand-independent adenylate cyclase-activating G protein-coupled receptor signaling pathway   • periplasmic space   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • endomembrane system   • trans-Golgi network   • receptor complex   • endosome membrane   • endosome   • intracellular vesicle   • cytoplasmic vesicle membrane   • vesicle membrane   • cytoplasmic vesicle
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8TB0_Chain_A
LSAEDKAAV ERSKMIEKQ LQKDKQVYR ATHRLLLLG AGESGKNTI 
VKQIFETKF QVDKVNFHM FDVGAQRDE RRKWIQCFN DVTAIIFVV 
ASSSTNRLQ AALKLFDSI WNNKWLRDT SVILFLNKQ DLLAEKVLA 
GKIEDYFPE FARYTTPED ATPEPGEDP RVTRAKYFI RDEFLRIST 
ASGDGRHYC YPHFTCDTE NIRRVFNDC RDIIQRMHL RQYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8TB0_Chain_B
RQEAEQLKN QIRDARKAC ADATLSQIT NNIDPVGRI QMRTRRTLR 
GHLAKIYAM HWGTDSRLL VSASQDGKL IIWDSYTTN KVHAIPLRS 
SWVMTCAYA PSGNYVACG GLDNICSIY NLKTREGNV RVSRELAGH 
TGYLSCCRF LDDNQIVTS SGDTTCALW DIETGQQTT TFTGHTGDV 
MSLSLAPDT RLFVSGACD ASAKLWDVR EGMCRQTFT GHESDINAI 
CFFPNGNAF ATGSDDATC RLFDLRADQ ELMTYSHDN IICGITSVS 
FSKSGRLLL AGYDDFNCN VWDALKADR AGVLAGHDN RVSCLGVTD 
DGMAVATGS WDSFLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8TB0_Chain_G
ARKLVEQLK MEANIDRIK VSKAAADLM AYCEAHAKE DPLLTPVPA 
SENPF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ9BZJ8
Sequence
>8TB0_Chain_R
ALFFMLLLD LTAVAGNAA VMAVIAKTP ALRKFVFVF HLCLVDLLA 
ALTLMPLAM LSSSALFDH ALFGEVACR LYLFLSVCF VSLAILSVS 
AINVERYYY VVHPMRYEV RMTLGLVAS VLVGVWVKA LAMASVPVL 
GGCSLQWSH SAYCQLFVV VFAVLYFLL PLLLILVVY CSMFRVARV 
AGKAAVVLL AVGGQFLLC WLPYFSFHL YVALSAQPI STGQVESVV 
TWIGYFCFT SNPFFYGCL NRQIRGELS


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8TB7AOrphanOrphanGPR61Homo sapiens-PubChem 168510218-2.942023-10-04doi.org/10.1038/s41467-023-41646-3
8TB0AOrphanOrphanGPR61Homo sapiens--chim(NtGi1-Gs)/β1/γ23.472023-10-04doi.org/10.1038/s41467-023-41646-3
8TB0 (No Gprot) AOrphanOrphanGPR61Homo sapiens--3.472023-10-04doi.org/10.1038/s41467-023-41646-3
8KGKAOrphanOrphanGPR61Homo sapiens--Gs/β1/γ23.162023-10-11doi.org/10.1038/s41467-023-41654-3
8KGK (No Gprot) AOrphanOrphanGPR61Homo sapiens--3.162023-10-11doi.org/10.1038/s41467-023-41654-3




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