Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L5 3.155402
2A:A:V34 4.902545
3A:A:L36 3.615447
4A:A:L39 6.0375409
5A:A:E65 5.78538
6A:A:N76 7.07479
7A:A:I84 4.092577
8A:A:I85 4.74404
9A:A:F95 3.885404
10A:A:D102 6.5075401
11A:A:V109 5.02471
12A:A:M119 3.78754433
13A:A:L123 2.932573
14A:A:I127 4.132576
15A:A:L130 4.29477
16A:A:D133 5.8725408
17A:A:V136 4.485476
18A:A:N149 4.486576
19A:A:Y155 7.935677
20A:A:I162 4.995407
21A:A:Y167 10.10254438
22A:A:R176 7.12667676
23A:A:H188 8.6325433
24A:A:H195 7.8025434
25A:A:F196 7.574547
26A:A:F199 7.49435
27A:A:V201 5.645439
28A:A:W211 6.8125439
29A:A:I212 4.6725438
30A:A:F215 6.496539
31A:A:T219 4.6275447
32A:A:I222 3.4725447
33A:A:F223 4.26409
34A:A:V225 4.205407
35A:A:D229 5.00754398
36A:A:Y230 4.78167658
37A:A:L234 4.295408
38A:A:M243 6.775458
39A:A:F250 6.8125409
40A:A:N255 7.35754458
41A:A:N256 4.3025438
42A:A:W258 9.285635
43A:A:F259 4.72167639
44A:A:I265 4.9975448
45A:A:F267 4.25649
46A:A:L268 5.692558
47A:A:F274 7.17459
48A:A:L283 5.994557
49A:A:C286 5.628556
50A:A:Y287 7.62333657
51A:A:Y290 8.7525457
52A:A:Y302 10.2556
53A:A:I303 4.025457
54A:A:F307 5.0825408
55A:A:I319 3.52254465
56A:A:Y320 9.28447
57A:A:H322 8.88449
58A:A:F323 5.7925454
59A:A:C325 3.1925407
60A:A:D328 5.5425409
61A:A:N331 9.5025448
62A:A:F336 10.122548
63A:A:V342 5.2725407
64B:B:D27 6.82408
65B:B:V40 5.316676223
66B:B:I43 3.384223
67B:B:L51 7.6754149
68B:B:H54 6.404297149
69B:B:W63 9.48407
70B:B:D76 5.91754149
71B:B:I81 3.985107
72B:B:W82 10.6256149
73B:B:Y85 8.3445344
74B:B:K89 7.166149
75B:B:I93 6.3645107
76B:B:L95 6.414108
77B:B:W99 8.105639
78B:B:Y105 5.714506
79B:B:Y111 6.2254494
80B:B:I123 4.9725496
81B:B:Y124 5.578336106
82B:B:L126 4.03254105
83B:B:L139 6.9575409
84B:B:H142 6.386159
85B:B:Y145 7.5154158
86B:B:F151 5.30333609
87B:B:L152 6.18503
88B:B:S160 4.424506
89B:B:G162 5.66754159
90B:B:D163 6.78254159
91B:B:W169 8.928336158
92B:B:F180 7.6045167
93B:B:H183 8.465169
94B:B:D205 4.9575409
95B:B:K209 10.08254166
96B:B:L210 5.51485
97B:B:W211 9.286676168
98B:B:Q220 8.465487
99B:B:H225 8.712589
100B:B:I232 4.7075408
101B:B:F235 5.725717356
102B:B:P236 6.394357
103B:B:F241 8.11486
104B:B:D247 5.534589
105B:B:T249 5.1625486
106B:B:R251 8.062588
107B:B:F253 9.27486
108B:B:D258 10.4525487
109B:B:Y264 6.956676175
110B:B:F278 4.946676357
111B:B:R283 9.864229
112B:B:L284 5.424225
113B:B:Y289 6.473336177
114B:B:N295 8.44176
115B:B:W297 6.225178
116B:B:H311 10.2625239
117B:B:R314 6.76538
118B:B:L318 4.5325406
119B:B:W332 5.76857739
120B:B:D333 7.244239
121B:B:L336 4.3454147
122B:B:K337 7.98254236
123B:B:W339 11.66254239
124B:B:N340 5.295409
125G:G:V16 4.4625407
126G:G:A23 1.9775408
127G:G:R27 8.1725488
128G:G:V30 5.564478
129G:G:Y40 10.14754356
130G:G:D48 6.368509
131G:G:P49 3.8725407
132G:G:V54 6.074526
133G:G:F61 5.998577348
134S:S:Y171 7.934245
135S:S:F176 7.0485257
136S:S:W182 9.69516
137S:S:Q189 6.5785254
138S:S:R202 3.76405
139S:S:L211 3.5075409
140S:S:Y228 7.54545
141S:S:Y230 7.878527
142S:S:E231 4.28254546
143S:S:Y234 7.5525
144S:S:P237 8.61254246
145S:S:K239 4.324247
146S:S:I240 5.595405
147S:S:I241 4.645537
148S:S:P244 4.4375418
149S:S:S247 4.955419
150S:S:V253 3.5475417
151S:S:M259 3.238525
152S:S:W260 7.40333627
153S:S:V264 3.0925419
154S:S:S266 4.9875418
155S:S:Y267 5.83407
156S:S:S269 5.2418
157S:S:S271 3.808519
158S:S:P272 3.86667617
159S:S:L274 6.49667618
160S:S:F280 7.85408
161S:S:F283 7.422518
162S:S:R285 4.4875419
163S:S:H287 5.95375817
164S:S:P288 7.71416
165S:S:H293 6.78415
166S:S:N294 6.095409
167S:S:R297 4.4875407
168S:S:W304 7.3256117
169S:S:W306 10.4554119
170S:S:E317 5.3175406
171S:S:V318 5.5125415
172S:S:F319 6.19517
173S:S:T322 3.55417
174S:S:L323 6.395406
175S:S:D325 8.7925406
176S:S:I335 3.705407
177S:S:F339 10.3575406
178S:S:S342 4.944197
179S:S:F343 8.444577
180S:S:F344 5.346676194
181S:S:P347 8.20254576
182S:S:V349 5.4775403
183S:S:P350 5.1775407
184S:S:R360 5.884189
185S:S:I361 7.624119
186S:S:I362 6.5154189
187S:S:L365 3.448506
188S:S:E368 5.8275417
189S:S:R372 4.458517
190S:S:F375 7.63408
191S:S:Y379 8.066587
192S:S:Y388 7.30254188
193S:S:V389 4.23754118
194S:S:F391 6.865407
195S:S:I393 4.9575415
196S:S:W395 6.58143715
197S:S:Y396 5.93515
198S:S:W400 6.25857718
199S:S:F401 6.914507
200S:S:D405 6.2525403
201S:S:C410 3.89254589
202S:S:H422 8.7525416
203S:S:I427 4.46833615
204S:S:M429 5.40667614
205S:S:N431 3.54406
206S:S:S439 4.84128
207S:S:M441 4.5325125
208S:S:F446 5.584127
209S:S:P458 6.9625403
210S:S:F464 5.76407
211S:S:E466 6.81415
212S:S:L469 4.185416
213S:S:Y471 5.995717129
214S:S:D472 6.02409
215S:S:I474 4.55254256
216S:S:W475 5.27254128
217S:S:I505 3.298506
218S:S:F518 5.9825129
219S:S:F527 4.01754559
220S:S:M534 5.5175415
221S:S:W536 6.4403
222S:S:L538 7.8125414
223S:S:E540 7.2416
224S:S:Q541 5.9025119
225S:S:L542 6.2525414
226S:S:Y547 7.50833615
227S:S:I550 4.35254117
228S:S:Y553 7.7145566
229S:S:D554 11.645405
230S:S:W562 7.506676115
231S:S:D566 6.5945115
232S:S:W568 7.746676119
233S:S:F584 6.39254604
234S:S:N616 4.5475405
235S:S:S625 4.1254209
236S:S:N630 4.44754209
237S:S:L641 4.44508
238S:S:P646 2.7875406
239S:S:I654 3.4765285
240S:S:R666 4.9575408
241S:S:W668 6.89406
242S:S:Y678 5.6665368
243S:S:M681 3.9245629
244S:S:F682 2.745369
245S:S:K684 5.396509
246S:S:W687 7.5875409
247S:S:H689 5.8175408
248S:S:E706 6.46754636
249S:S:L710 6.2525408
250S:S:L725 7.005408
251S:S:D732 5.116508
252S:S:R736 4.525405
253S:S:F741 6.6154275
254S:S:I754 5.815275
255S:S:P756 3.6925275
256S:S:Q757 9.31754605
257S:S:Y774 4.646506
258S:S:L781 4.875368
259S:S:T791 2.9775409
260S:S:I799 7.18754618
261S:S:D801 6.37254209
262S:S:Y810 6.271676219
263S:S:I818 4.4275407
264S:S:T819 3.0575408
265S:S:L826 3.735656
266S:S:F834 7.295407
267S:S:V842 2.765405
268S:S:F853 5.138509
269S:S:L860 4.62406
270R:R:M59 5.78143727
271R:R:Y97 6.7325408
272R:R:L99 1.7654688
273R:R:Y104 6.695426
274R:R:E107 7.80254675
275R:R:F117 7.0825427
276R:R:Y118 6.64727
277R:R:I121 5.678526
278R:R:P125 5.19427
279R:R:H127 7.754528
280R:R:V130 3.84526
281R:R:W149 6.23571727
282R:R:F156 5.4275406
283R:R:L163 6.2325428
284R:R:F172 6.68667628
285R:R:F173 6.454297
286R:R:R174 7.42429
287R:R:V176 4.594406
288R:R:P177 3.83754406
289R:R:N183 4.91254309
290R:R:I186 2.92754697
291R:R:Y193 8.3785318
292R:R:W195 9.9725409
293R:R:R197 7.2025136
294R:R:V198 3.7825408
295R:R:L201 4.4025407
296R:R:Q203 5.802567
297R:R:R212 6.847147265
298R:R:I226 3.79754266
299R:R:E230 9.1154708
300R:R:F232 7.746567
301R:R:P236 8.525405
302R:R:L243 5.1854708
303R:R:K244 4.1345138
304R:R:R249 8.1265139
305R:R:F255 5.782568
306R:R:M259 5.385464
307R:R:V263 5.94407
308R:R:F264 5.5775467
309R:R:Y277 4.6154138
310R:R:W279 6.4625409
311R:R:I281 5.106566
312R:R:W284 6.76566
313R:R:Y285 7.25765
314R:R:W289 7.326569
315R:R:W290 8.09566
316R:R:M311 5.77167665
317R:R:Y314 7.04833665
318R:R:F319 7.8085404
319R:R:E320 7.09254724
320R:R:S331 6.8175498
321R:R:K333 7.575495
322R:R:P335 3.4225404
323R:R:Y338 6.725697
324R:R:Y342 7.755697
325R:R:R346 7.005494
326R:R:F354 5.776505
327R:R:Y357 7.434405
328R:R:Y359 8.098599
329R:R:D360 6.7025409
330R:R:I362 4.0265686
331R:R:W363 6.526598
332R:R:V364 3.75407
333R:R:I365 5.26405
334R:R:F388 5.138507
335R:R:Y390 5.64428
336R:R:L400 5.1425293
337R:R:M403 5.964295
338R:R:F408 7.1575409
339R:R:F409 5.22754732
340R:R:V411 5.6675407
341R:R:V415 5.49408
342R:R:F428 5.1125408
343R:R:Q430 4.2685319
344R:R:Q432 7.63407
345R:R:K438 5.84754723
346R:R:Y442 5.666676376
347R:R:I456 4.5685314
348R:R:F458 6.314319
349R:R:Y482 4.2854775
350R:R:T489 5.275407
351R:R:M519 4.4065786
352R:R:I524 5.0265327
353R:R:Y531 4.902508
354R:R:F535 4.01754776
355R:R:D540 6.344428
356R:R:V544 3.1154795
357R:R:T548 2.72254792
358R:R:F568 6.735388
359R:R:H579 4.5675408
360R:R:K588 6.22446
361R:R:D608 3.6575409
362R:R:W615 9.7245339
363R:R:D619 4.5285339
364R:R:P634 5.63254411
365R:R:I639 5.6785414
366R:R:L644 4.87404
367R:R:H647 8.5954815
368R:R:W656 12.234338
369R:R:Y663 4.4225405
370R:R:M668 3.8145388
371R:R:I683 3.14407
372R:R:V696 2.713336389
373R:R:M702 5.9125407
374R:R:F721 5.1254767
375R:R:V739 3.21754328
376R:R:F740 6.675329
377R:R:K743 2.99409
378M:M:?1001 8.1971010
379W:W:?901 9.638577210
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:H54 B:B:I58 11.61166.63YesNo099
2B:B:I58 B:B:S316 60.24383.1NoNo099
3B:B:S316 B:B:W332 63.1153.71NoYes099
4A:A:W258 B:B:W332 64.06176.56YesYes359
5A:A:F199 A:A:F215 20.48474.29YesYes359
6A:A:F199 A:A:K197 36.94112.48YesNo356
7B:B:I58 B:B:L336 48.4284.28NoYes097
8A:A:F259 A:A:W258 56.63833.01YesYes395
9A:A:F259 A:A:I212 33.21555.02YesYes398
10A:A:H188 A:A:K197 35.84565.24YesNo336
11A:A:I212 A:A:W211 24.60587.05YesYes389
12A:A:V201 A:A:W211 38.76696.13YesYes399
13A:A:Q204 A:A:V201 99.9894.3NoYes099
14A:A:Q204 A:A:R208 99.9962.34NoNo099
15A:A:L249 A:A:R208 99.99816.07NoNo099
16A:A:F223 A:A:L249 1002.44YesNo099
17A:A:F223 A:A:L266 98.37593.65YesNo099
18A:A:L266 A:A:L268 93.8666.92NoYes098
19A:A:F323 A:A:L268 95.58017.31YesYes548
20A:A:F323 A:A:K271 95.75213.72YesNo045
21A:A:C325 A:A:K271 95.744.85YesNo075
22A:A:C325 A:A:D328 95.85061.56YesYes079
23A:A:D328 A:A:N331 95.79469.42YesYes098
24A:A:H322 A:A:N331 95.30367.65YesYes498
25A:A:F267 A:A:H322 95.47144.53YesYes499
26A:A:F267 A:A:I222 94.51873.77YesYes497
27A:A:I222 A:A:L36 94.22952.85YesYes477
28A:A:F259 A:A:I221 24.59153.77YesNo398
29A:A:I221 A:A:L39 24.72534.28NoYes089
30A:A:L39 A:A:V201 25.11374.47YesYes099
31A:A:L36 A:A:V339 92.87142.98YesNo478
32A:A:E65 A:A:Y69 33.98323.37YesNo085
33A:A:E65 A:A:H188 34.98113.54YesYes383
34A:A:V174 A:A:Y69 32.92075.05NoNo085
35A:A:R178 A:A:V174 32.70786.54NoNo098
36A:A:L175 A:A:R178 32.49483.64NoNo089
37A:A:L175 A:A:Q172 32.06833.99NoNo086
38A:A:Q172 A:A:Y154 31.854923.67NoNo069
39A:A:R176 A:A:Y154 31.41854.12YesNo769
40A:A:R176 A:A:Y155 25.333316.46YesYes767
41A:A:S80 A:A:Y155 24.05765.09NoYes777
42A:A:I127 A:A:S80 14.84364.64YesNo767
43A:A:F215 B:B:W99 10.62899.02YesYes399
44B:B:L117 B:B:W99 35.625612.53NoYes099
45B:B:L117 B:B:M101 35.51052.83NoNo099
46B:B:M101 B:B:Y145 35.285.99NoYes098
47B:B:M188 B:B:Y145 25.72773.59NoYes088
48B:B:C204 B:B:M188 25.6054.86NoNo078
49B:B:C204 B:B:D228 25.482612.45NoNo079
50A:A:T340 A:A:V339 94.41171.59NoNo068
51A:A:I344 A:A:T340 94.38921.52NoNo066
52A:A:I344 A:A:L348 94.34392.85NoNo069
53A:A:L348 A:A:N347 94.32115.49NoNo098
54A:A:N347 R:R:I591 94.29819.91NoNo084
55R:R:I581 R:R:I591 93.8225.89NoNo084
56R:R:I581 R:R:R577 93.79833.76NoNo089
57R:R:R577 R:R:S516 94.10977.91NoNo099
58R:R:K574 R:R:S516 91.89753.06NoNo7899
59R:R:K574 R:R:N520 93.43996.99NoNo099
60R:R:F740 R:R:N520 93.41244.83YesNo099
61R:R:F740 R:R:I524 46.55117.54YesYes3297
62B:B:D228 B:B:S227 24.84191.47NoNo096
63B:B:D247 B:B:S227 24.50261.47YesNo096
64B:B:D247 B:B:R251 15.48494.76YesYes898
65B:B:Y85 G:G:F61 10.87048.25YesYes3448
66B:B:N340 G:G:F61 30.52284.83YesYes098
67B:B:M45 B:B:N340 25.97789.82NoYes049
68B:B:I43 B:B:M45 19.45062.92YesNo034
69B:B:I43 B:B:V40 18.13913.07YesYes2233
70B:B:R283 B:B:V40 16.8477.85YesYes2293
71B:B:L300 B:B:R283 16.41099.72NoYes069
72B:B:L300 G:G:C41 15.72066.35NoNo067
73B:B:F235 G:G:C41 15.49022.79YesNo067
74B:B:F235 B:B:F278 12.01275.36YesYes3567
75B:B:F278 B:B:L285 10.87088.53YesNo076
76B:B:L285 B:B:Y264 10.40398.21NoYes065
77B:B:I338 B:B:L51 42.9122.85NoYes059
78B:B:I338 G:G:F61 42.75175.02NoYes058
79B:B:H225 B:B:I229 13.66610.61YesNo897
80B:B:G202 B:B:I229 13.80085.29NoNo067
81B:B:A203 B:B:G202 13.52961.95NoNo086
82B:B:A203 B:B:H183 10.79235.85NoYes089
83R:R:F499 R:R:F740 45.595310.72NoYes079
84R:R:F499 R:R:M495 45.46414.98NoNo074
85R:R:M495 R:R:T733 45.39843.01NoNo048
86R:R:T733 R:R:Y531 45.33353.75NoYes088
87R:R:T489 R:R:Y531 88.85943.75YesYes078
88R:R:I534 R:R:T489 83.691810.64NoYes087
89R:R:I534 R:R:I728 81.55427.36NoNo088
90R:R:I728 R:R:V724 80.99443.07NoNo084
91R:R:F537 R:R:V724 80.82555.24NoNo054
92R:R:F537 R:R:R556 80.7111.76NoNo057
93R:R:C553 R:R:R556 80.37144.18NoNo097
94R:R:C553 R:R:C648 79.41757.28NoNo8099
95R:R:C648 R:R:L621 79.35253.17NoNo096
96R:R:L621 R:R:W615 79.18223.42NoYes069
97R:R:M653 R:R:W615 74.6884.65NoYes3359
98R:R:L657 R:R:M653 74.73622.83NoNo055
99R:R:F711 R:R:L657 70.18957.31NoNo055
100R:R:F711 R:R:S710 65.5553.96NoNo057
101R:R:Q720 R:R:S710 65.3752.89NoNo057
102R:R:Q720 R:R:T713 65.19494.25NoNo056
103R:R:T713 R:R:V719 65.01464.76NoNo066
104R:R:V719 S:S:I825 64.47313.07NoNo066
105S:S:I825 S:S:L826 64.29232.85NoYes066
106S:S:L826 S:S:V822 63.56792.98YesNo066
107S:S:F836 S:S:V822 63.02326.55NoNo066
108S:S:F836 S:S:T819 62.65942.59NoYes068
109S:S:I818 S:S:T819 61.93043.04YesYes078
110R:R:I701 S:S:I818 60.09862.94NoYes067
111R:R:I701 S:S:L815 59.91472.85NoNo067
112S:S:L815 S:S:N811 59.73064.12NoNo078
113R:R:Y697 S:S:N811 59.36225.81NoNo098
114R:R:Y697 S:S:Y810 58.77112.98NoYes2199
115S:S:I785 S:S:Y810 56.75063.63NoYes069
116S:S:A813 S:S:I785 56.56443.25NoNo076
117S:S:A813 S:S:L781 56.37814.73NoYes078
118S:S:F674 S:S:L781 32.93943.65NoYes3698
119S:S:F674 S:S:K777 33.88737.44NoNo099
120S:S:D721 S:S:K777 33.08069.68NoNo099
121S:S:D721 S:S:L725 31.4612.71NoYes098
122S:S:G671 S:S:L725 20.31341.71NoYes068
123S:S:G671 S:S:L670 20.10591.71NoNo068
124S:S:I841 S:S:L670 16.52952.85NoNo078
125S:S:I841 S:S:V644 12.07963.07NoNo078
126S:S:S838 S:S:V644 11.73443.23NoNo078
127S:S:F834 S:S:S838 10.66443.96YesNo077
128R:R:I524 R:R:M528 45.74082.92YesNo3275
129R:R:M493 R:R:M528 45.7064.33NoNo085
130R:R:M493 R:R:Y531 45.64043.59NoYes088
131S:S:L667 S:S:L725 10.082711.07NoYes058
132S:S:L781 S:S:Y678 22.50529.38YesYes3688
133S:S:I809 S:S:Y678 21.9874.84NoYes088
134S:S:I809 S:S:M681 17.05475.83NoYes089
135B:B:L336 B:B:L51 43.31835.54YesYes1479
136B:B:R68 B:B:Y85 10.117216.46NoYes3454
137A:A:F215 A:A:W211 14.14727.02YesYes399
138A:A:F199 B:B:W99 16.876815.03YesYes359
139A:A:I184 B:B:W99 36.34535.87NoYes399
140A:A:I184 A:A:V201 36.3817.68NoYes399
141S:S:H287 S:S:L469 12.77825.14YesYes176
142M:M:?1001 S:S:H287 14.57735.84YesYes107
143M:M:?1001 S:S:Y367 13.662811.54YesNo007
144S:S:I393 S:S:L365 15.8352.85YesYes056
145S:S:L323 S:S:L365 18.22894.15YesYes066
146S:S:L323 S:S:Q313 11.41637.99YesNo067
147S:S:Q313 S:S:S342 11.28795.78NoYes077
148S:S:S342 S:S:T315 11.38173.2YesNo1976
149S:S:F344 S:S:T315 11.29123.89YesNo1946
150R:R:W149 R:R:Y118 13.22152.89YesYes277
151R:R:Y118 S:S:L229 15.55133.52YesNo077
152M:M:?1001 S:S:S247 12.03476.82YesYes109
153S:S:S247 S:S:S269 15.03524.89YesYes198
154S:S:P244 S:S:V253 14.00773.53YesYes187
155S:S:L323 S:S:T311 11.75777.37YesNo067
156S:S:I337 S:S:T311 11.59544.56NoNo067
157S:S:I309 S:S:I337 10.29714.42NoNo086
158S:S:F319 S:S:Y367 13.63078.25YesNo077
159S:S:F319 S:S:Q314 25.84324.68YesNo178
160S:S:E370 S:S:Q314 28.068719.11NoNo058
161S:S:E370 S:S:F343 27.93228.16NoYes057
162S:S:F343 S:S:P350 27.50455.78YesYes077
163S:S:P350 S:S:V349 17.96993.53YesYes073
164R:R:E210 S:S:F344 10.45064.66NoYes064
165S:S:W400 S:S:Y396 11.686910.61YesYes185
166M:M:?1001 S:S:Y396 10.21553.55YesYes105
167R:R:R212 S:S:N353 17.56433.62YesNo056
168S:S:F518 S:S:V525 13.02911.8YesNo098
169S:S:R533 S:S:V525 12.12283.92NoNo098
170R:R:D318 R:R:F319 10.002910.75NoYes064
171R:R:D318 R:R:W284 10.07413.35NoYes066
172R:R:R207 R:R:W284 10.40459NoYes056
173R:R:D179 R:R:R207 15.82313.57NoNo075
174R:R:D179 R:R:P161 15.88068.05NoNo076
175R:R:E210 R:R:P161 10.4373.14NoNo066
176R:R:L190 R:R:V198 15.67852.98NoYes058
177R:R:I224 R:R:V198 31.99243.07NoYes068
178R:R:I224 R:R:L219 25.10335.71NoNo066
179R:R:I226 R:R:L219 25.21532.85YesNo066
180R:R:I226 R:R:R212 25.28736.26YesYes2665
181R:R:L190 R:R:W195 10.68565.69NoYes059
182R:R:I250 R:R:W195 10.67616.44NoYes099
183R:R:I250 R:R:V198 10.89024.61NoYes098
184R:R:W195 R:R:Y193 16.132714.47YesYes098
185R:R:I456 R:R:Y193 12.65554.84YesYes3148
186S:S:L229 S:S:V253 17.35934.47NoYes077
187S:S:F319 S:S:L365 12.56423.65YesYes076
188S:S:M534 S:S:R533 11.07096.2YesNo059
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:G181 S:S:Y367 5.79 0 No No 5 7 2 1
S:S:P183 S:S:W182 4.05 0 No Yes 4 6 2 1
S:S:G184 S:S:W182 9.85 0 No Yes 5 6 2 1
S:S:G463 S:S:W182 4.22 0 No Yes 4 6 2 1
S:S:E466 S:S:W182 13.08 1 Yes Yes 5 6 1 1
M:M:?1001 S:S:W182 17.25 1 Yes Yes 0 6 0 1
S:S:C220 S:S:C246 7.28 0 No No 8 7 2 1
S:S:S247 S:S:S269 4.89 1 Yes Yes 9 8 1 2
S:S:S247 S:S:S271 3.26 1 Yes Yes 9 9 1 2
S:S:S247 S:S:V318 4.85 1 Yes Yes 9 5 1 2
M:M:?1001 S:S:S247 6.82 1 Yes Yes 0 9 0 1
S:S:G268 S:S:H287 4.77 0 No Yes 7 7 2 1
S:S:H287 S:S:S270 6.97 1 Yes No 7 7 1 1
S:S:A290 S:S:S270 3.42 1 No No 8 7 2 1
M:M:?1001 S:S:S270 7.96 1 Yes No 0 7 0 1
S:S:S271 S:S:V318 4.85 1 Yes Yes 9 5 2 2
S:S:H287 S:S:P288 10.68 1 Yes Yes 7 6 1 2
S:S:H287 S:S:W395 5.29 1 Yes Yes 7 5 1 1
S:S:H287 S:S:M429 5.25 1 Yes Yes 7 4 1 2
S:S:E466 S:S:H287 3.69 1 Yes Yes 5 7 1 1
S:S:H287 S:S:L469 5.14 1 Yes Yes 7 6 1 2
M:M:?1001 S:S:H287 5.84 1 Yes Yes 0 7 0 1
S:S:I427 S:S:P288 3.39 1 Yes Yes 5 6 2 2
S:S:M429 S:S:P288 6.71 1 Yes Yes 4 6 2 2
S:S:H293 S:S:W395 9.52 1 Yes Yes 5 5 2 1
S:S:H293 S:S:I427 3.98 1 Yes Yes 5 5 2 2
S:S:F319 S:S:V318 9.18 1 Yes Yes 7 5 2 2
S:S:F319 S:S:L365 3.65 1 Yes Yes 7 6 2 2
S:S:F319 S:S:Y367 8.25 1 Yes No 7 7 2 1
S:S:I393 S:S:L365 2.85 1 Yes Yes 5 6 1 2
M:M:?1001 S:S:Y367 11.54 1 Yes No 0 7 0 1
S:S:E368 S:S:Y396 7.86 1 Yes Yes 7 5 2 1
S:S:E368 S:S:W400 5.45 1 Yes Yes 7 8 2 2
S:S:A371 S:S:Y396 4 1 No Yes 8 5 2 1
S:S:A371 S:S:W400 3.89 1 No Yes 8 8 2 2
S:S:I393 S:S:W395 4.7 1 Yes Yes 5 5 1 1
S:S:I393 S:S:Y396 3.63 1 Yes Yes 5 5 1 1
M:M:?1001 S:S:I393 8.65 1 Yes Yes 0 5 0 1
S:S:I427 S:S:W395 3.52 1 Yes Yes 5 5 2 1
S:S:M429 S:S:W395 4.65 1 Yes Yes 4 5 2 1
S:S:E466 S:S:W395 5.45 1 Yes Yes 5 5 1 1
M:M:?1001 S:S:W395 12.94 1 Yes Yes 0 5 0 1
S:S:W400 S:S:Y396 10.61 1 Yes Yes 8 5 2 1
M:M:?1001 S:S:Y396 3.55 1 Yes Yes 0 5 0 1
S:S:I427 S:S:M429 7.29 1 Yes Yes 5 4 2 2
S:S:L469 S:S:M429 5.65 1 Yes Yes 6 4 2 2
M:M:?1001 S:S:E466 5.02 1 Yes Yes 0 5 0 1
M:M:?1001 S:S:C246 2.4 1 Yes No 0 7 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
100.00Single6D35Cholesterol6D35-SMO-Cholesterol
100.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
100.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
100.00Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
100.00Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
100.00Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042
100.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
100.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
100.00Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-BHFF
100.00Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
100.00Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626
100.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
100.00Single7DTTCa7DTT-CaS-Ca-Ca
100.00Single7DTTCa7DTT-CaS-Ca-Ca
100.00Single7DTUTryptophan7DTU-CaS-Tryptophan
100.00Single7DTUTryptophan7DTU-CaS-Tryptophan
100.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
100.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
100.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
100.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
100.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
100.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
100.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
100.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
100.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
100.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
100.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
100.00Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
100.00Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
100.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
100.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
100.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
100.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
100.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
100.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
100.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00Single7T9NM22 Fab7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
100.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
100.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
100.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
100.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
100.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
100.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
100.00Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
100.00Single7XW7K1-707XW7-TSH-K1-70
100.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
100.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
100.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
100.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
100.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
100.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
100.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
100.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
100.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
100.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
100.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
100.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
100.00Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
100.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
100.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
100.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
100.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
100.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
100.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
100.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
100.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
100.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
100.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
100.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
100.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
100.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
100.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
100.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
100.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
100.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
100.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
100.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
100.00Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
100.00Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
100.00Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
100.00Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
100.00Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
100.00Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
100.00Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
100.00Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
100.00Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
100.00Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
100.00Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
100.00Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
100.00Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
100.00Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
100.00Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
100.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
100.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
100.00Single8WVXNorrin8WVX-LGR4-Norrin
100.00Single8WVYNorrin8WVY-LGR4-Norrin
100.00Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
100.00Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
100.00Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
100.00Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
100.00Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
100.00Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
100.00Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
100.00Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
100.00Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
100.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
100.00Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
100.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
100.00Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
100.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
100.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
100.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
100.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
100.00Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
100.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
100.00Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
100.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
100.00Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
100.00Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
100.00Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
100.00Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
100.00Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
100.00Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
100.00Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
100.00Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
100.00Single9KHHNorrin9KHH-LGR4-Norrin
100.00Single9S37NB219S37-LGR4-NB21
100.00Single9UTBSucralose9UTB-TAS1R2; TAS1R3-Sucralose
50.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
50.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
50.00Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
50.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
50.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
50.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
33.33Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
33.33Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
25.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
25.00Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
25.00Single7UTZTR14027UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
25.00Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
25.00Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
20.00Single5L7DCholesterol5L7D-SMO-Cholesterol
20.00Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
20.00Single8HS2Fab0468HS2-GPR20-Fab046
20.00Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
20.00Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
20.00Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
16.67Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
16.67Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
16.67Consensusp2y_offOrthosteric Ligandp2y1_off
14.29Single4XNWMRS25004XNW-P2Y1-MRS2500
14.29Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
14.29Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
14.29Single8JPSCCL78JPS-ACKR1-CCL7
14.29Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
14.29Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
12.50Single4O9RCyclopamine4O9R-SMO-Cyclopamine
12.50Single6LI0C176LI0-GPR52-C17
12.50Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
12.50Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
12.50Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
12.50Single9B9Y7DY9B9Y-CB1-7DY
12.50Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.11Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
11.11Single4BWBNeurotensin4BWB-NTS1-Neurotensin
11.11Single4QINSAG1.54QIN-SMO-SAG1.5
11.11Single5U09Taranabant5U09-CB1-Taranabant
11.11Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
11.11Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
11.11Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
11.11Single7BR3Elagolix7BR3-GnRH1-Elagolix
11.11Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
11.11Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
11.11Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
11.11Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
11.11Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
11.11Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
11.11Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
11.11Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
11.11Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
11.11Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
11.11Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
11.11Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
11.11Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
11.11Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
11.11Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
10.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
10.00Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
10.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
10.00Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
10.00Single7VV6C48/807VV6-MRGPRX2-C48/80
10.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
10.00Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
10.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single9BA0A1AKN9BA0-CB1-A1AKN
10.00Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
10.00Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
10.00Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
10.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
10.00Consensusgrh_offOrthosteric Ligandgnrh1_off
10.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
10.00Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
9.09Single4QIMANTA XV4QIM-SMO-ANTA XV
9.09Single5T04Neurotensin5T04-NTS1-Neurotensin
9.09Single5TGZAM65385TGZ-CB1-AM6538
9.09Single6D27CAY104716D27-DP2-CAY10471
9.09Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
9.09Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
9.09Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
9.09Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
9.09Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
9.09Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
9.09Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
9.09Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
9.09Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
9.09Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
9.09Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
9.09Single7YXAONO-54306087YXA-S1P5-ONO-5430608
9.09Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
9.09Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
9.09Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
9.09Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
9.09Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
9.09Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
8.33Single4JKVTaladegib4JKV-SMO-Taladegib
8.33Single5C1MBU725C1M-μ-BU72
8.33Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
8.33Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
8.33Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
8.33Single7C4SS1P7C4S-S1P3-S1P
8.33Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
8.33Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
8.33Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
8.33Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
8.33Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
8.33Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
8.33Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single8ZYTNeurotensin peptide 8-138ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
8.33Single9B9ZA1AKO9B9Z-CB1-A1AKO
8.33Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
8.33Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
8.33Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
8.33Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
8.33Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
8.33Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
7.69Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
7.69Single4BV0Neurotensin4BV0-NTS1-Neurotensin
7.69Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
7.69Single5V56TC1145V56-SMO-TC114
7.69Single5V57TC1145V57-SMO-TC114
7.69Single6OS1TRV0266OS1-AT1-TRV026
7.69Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
7.69Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
7.69Single7F1TMIP-1a7F1T-CCR5-MIP-1a
7.69Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
7.69Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
7.69Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
7.69Single7R0CAVP7R0C-V2-AVP-Arrestin2
7.69Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
7.69Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
7.69Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
7.69Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
7.69Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
7.69Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
7.69Single8E0GBU728E0G-μ-BU72
7.69Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
7.69Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
7.69Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
7.69Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
7.69Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
7.69Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
7.69Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
7.69Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
7.69Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
7.69Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
7.69Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
7.69Consensuslpa_onOrthosteric Ligandlpa1_on
7.69Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
7.69Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Consensusneurotensin_onOrthosteric Ligandnts1_on
7.69Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
7.69Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
7.69Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
7.69Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
7.14Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
7.14Single4XEENeurotensin4XEE-NTS1-Neurotensin
7.14Single4XESNeurotensin4XES-NTS1-Neurotensin
7.14Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
7.14Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
7.14Single6OS2TRV0266OS2-AT1-TRV026
7.14Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
7.14Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
7.14Single6YVRNTS8-136YVR-NTS1-NTS8-13
7.14Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
7.14Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
7.14Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
7.14Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
7.14Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
7.14Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
7.14Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
7.14Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
7.14Single8XQJJN2418XQJ-Apelin-JN241
7.14Single8XWACXCL18XWA-CXCR2-CXCL1
7.14Single8XWMCXCL68XWM-CXCR2-CXCL6
7.14Single8XWSCXCL58XWS-CXCR2-CXCL5
7.14Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
7.14Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
7.14Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
7.14Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
7.14Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
7.14Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
7.14Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
7.14Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
7.14Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
7.14Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
7.14Consensuslpa_offOrthosteric Ligandlpa1_off
7.14Consensuslpl_offOrthosteric Ligands1p_off lpa_off
7.14Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
7.14Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
7.14Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
7.14Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
7.14Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
7.14Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
7.14Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
6.67Single4BUONeurotensin4BUO-NTS1-Neurotensin
6.67Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
6.67Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
6.67Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
6.67Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
6.67Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
6.67Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
6.67Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
6.67Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
6.67Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
6.67Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
6.67Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
6.67Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
6.67Single8JPFNeurotensin8JPF-NTS1-Neurotensin-SBI-553
6.67Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
6.67Single8XVUCXCL28XVU-CXCR2-CXCL2
6.67Single8XWFCXCL38XWF-CXCR2-CXCL3
6.67Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
6.67Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
6.67Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
6.67Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
6.67Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
6.67Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
6.67Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
6.67Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
6.67Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
6.25Single6KNMJN241-96KNM-Apelin-JN241-9
6.25Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
6.25Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
6.25Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
6.25Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
6.25Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
6.25Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
6.25Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
6.25Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
6.25Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
6.25Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single8QJ2pN1628QJ2-MC4-pN162-Gs
6.25Single8XQJJN2418XQJ-Apelin-JN241
6.25Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
6.25Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
6.25Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
6.25Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
6.25Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
6.25Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
5.88Single4XT1Fractalkine4XT1-US28-Fractalkine
5.88Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
5.88Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
5.88Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
5.88Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
5.88Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
5.88Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.88Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
5.88Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
5.88Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
5.88Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
5.88Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
5.88Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.88Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
5.88Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
5.88Single8XWNCXCL88XWN-CXCR2-CXCL8
5.88Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
5.88Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
5.88Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
5.88Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
5.88Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.88Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.88Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
5.88Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
5.88Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
5.88Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
5.88Consensuslpl_onOrthosteric Ligands1p_on lpa_on
5.88Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
5.88Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
5.88Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
5.56Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
5.56Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
5.56Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
5.56Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
5.56Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
5.56Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
5.56Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
5.56Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
5.56Single7SK5CXCL127SK5-ACKR3-CXCL12
5.56Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
5.56Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
5.56Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
5.56Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
5.56Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
5.56Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
5.56Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
5.56Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
5.56Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
5.56Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
5.56Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
5.26Single3OE0CVX153OE0-CXCR4-CVX15
5.26Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
5.26Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.26Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
5.26Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
5.26Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
5.26Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
5.26Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
5.26Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
5.26Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
5.26Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
5.26Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
5.26Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
5.26Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
5.26Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
5.26Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
5.26Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.26Consensusangiotensin_onOrthosteric Ligandat1_on
5.26Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
5.26Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
5.26Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
5.26Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
5.26Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
5.26Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
5.26Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
5.26Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
5.26Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
5.26Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
5.26Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
5.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
5.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
5.00Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
5.00Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
5.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
5.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
5.00Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
5.00Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
5.00Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
5.00Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
5.00Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
5.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
5.00Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
5.00Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
5.00Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
5.00Single9BLCCagrilintide backbone (non-acylated)9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
5.00Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
5.00Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
5.00Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
5.00Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
5.00Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
5.00Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
5.00Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
5.00Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
5.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
5.00Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
5.00Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
5.00Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
5.00Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
5.00Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
5.00Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
5.00Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
5.00Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
5.00Consensusvasop-oxy_onOrthosteric Ligandv2_on
5.00Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
4.76Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
4.76Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
4.76Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
4.76Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
4.76Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
4.76Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
4.76Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
4.76Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
4.76Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
4.76Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
4.76Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.76Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
4.76Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
4.76Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
4.76Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
4.76Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
4.76Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
4.76Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
4.76Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
4.76Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
4.76Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
4.76Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
4.76Consensuscalcitonin_onOrthosteric Ligandctlike_on
4.76Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
4.76Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
4.76Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
4.76Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
4.76Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
4.76Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
4.76Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
4.76Consensuspac_onOrthosteric Ligandpac1_on
4.76Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
4.76Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
4.55Single4XT3Fractalkine4XT3-US28-Fractalkine
4.55Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
4.55Single6FJ3PTH6FJ3-PTH1-PTH
4.55Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
4.55Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
4.55Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
4.55Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
4.55Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
4.55Single7SK3CXCL127SK3-ACKR3-CXCL12
4.55Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
4.55Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
4.55Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
4.55Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
4.55Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
4.55Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
4.55Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
4.55Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
4.55Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
4.55Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
4.55Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
4.55Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
4.55Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
4.55Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
4.55Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
4.55Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
4.55Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
4.55Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
4.55Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
4.55Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
4.55Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
4.55Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
4.55Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
4.55Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
4.55Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
4.55Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
4.55Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
4.35Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
4.35Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
4.35Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
4.35Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
4.35Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
4.35Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
4.35Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
4.35Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
4.35Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
4.35Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
4.35Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
4.35Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
4.35Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.35Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
4.35Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
4.35Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3
4.35Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
4.35Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
4.35Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
4.35Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
4.35Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
4.35Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
4.35Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
4.35Consensusglp_onOrthosteric Ligandglp1_on glp2_on
4.35Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
4.35Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
4.35Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.35Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.35Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
4.35Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
4.17Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
4.17Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
4.17Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
4.17Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
4.17Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
4.17Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
4.17Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
4.17Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
4.17Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
4.17Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
4.17Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
4.17Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
4.17Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
4.17Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
4.17Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
4.17Single8IY6Endothelin-18IY6-ETB-Endothelin-1
4.17Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
4.17Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
4.17Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
4.17Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
4.17Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
4.17Consensusbradykinin_onOrthosteric Ligandbk2_on
4.17Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
4.17Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
4.17Consensusendothelin_onOrthosteric Ligandetb_on eta_on
4.17Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
4.17Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
4.17Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
4.17Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
4.17Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
4.17Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
4.17Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
4.00Single5GLHEndothelin-15GLH-ETB-Endothelin-1
4.00Single6IGKEndothelin-36IGK-ETB-Endothelin-3
4.00Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
4.00Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
4.00Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
4.00Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
4.00Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
4.00Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
4.00Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
4.00Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
4.00Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
4.00Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
4.00Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
3.85Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
3.85Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
3.85Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
3.85Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
3.85Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
3.85Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
3.85Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
3.85Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
3.85Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
3.85Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
3.85Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
3.85Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
3.70Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
3.70Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
3.70Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
3.70Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
3.70Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
3.70Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
3.70Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.70Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
3.70Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
3.70Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
3.57Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
3.57Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
3.57Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
3.57Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
3.57Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
3.57Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
3.57Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
3.57Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.57Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
3.57Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
3.57Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
3.45Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
3.45Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
3.45Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
3.45Consensuspth_onOrthosteric Ligandpth1_on pth2_on
3.33Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
3.33Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
3.33Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
3.23Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
3.23Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
3.23Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
3.12Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
3.03Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
3.03Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
2.86Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
2.78Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:I785 S:S:Y810 3.63 0 No Yes 6 9 2 1
S:S:K792 S:S:Y789 7.17 21 No No 9 8 1 1
S:S:Y789 W:W:?901 12.6 21 No Yes 8 0 1 0
S:S:K792 W:W:?901 12.4 21 No Yes 9 0 1 0
S:S:V814 S:S:Y810 8.83 0 No Yes 6 9 2 1
R:R:M694 S:S:Y810 7.18 21 No Yes 6 9 1 1
R:R:Y697 S:S:Y810 2.98 21 No Yes 9 9 2 1
R:R:N698 S:S:Y810 8.14 21 No Yes 9 9 2 1
S:S:Y810 W:W:?901 6.87 21 Yes Yes 9 0 1 0
R:R:K690 W:W:?901 17.91 0 No Yes 8 0 1 0
R:R:P742 R:R:Y691 8.34 0 No No 9 6 2 1
R:R:Y691 W:W:?901 8.02 0 No Yes 6 0 1 0
R:R:M694 R:R:N698 5.61 21 No No 6 9 1 2
R:R:M694 W:W:?901 6.91 21 No Yes 6 0 1 0
R:R:N698 R:R:Y697 3.49 21 No No 9 9 2 2
S:S:M807 W:W:?901 2.76 0 No Yes 7 0 1 0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
66.67Single7C7QBHFF7C7Q-GABAB1, GABAB2-Baclofen-BHFF
55.56Single7CA3rac-BHFF7CA3-GABAB1, GABAB2-rac-BHFF
42.86Single6UO8GS397836UO8-GABAB1, GABAB2-SKF97541-GS39783
30.00Single5EE7MK08935EE7-Glucagon-MK0893
27.27Single5VEXNNC06405VEX-GLP-1-NNC0640
27.27Single6KK7PF-063722226KK7-GLP-1-PF-06372222
25.00Single5VEWPF-063722225VEW-GLP-1-PF-06372222
25.00Single6KJVPF-063722226KJV-GLP-1-PF-06372222
25.00Single6KK1PF-063722226KK1-GLP-1-PF-06372222
23.53Single6LN2PF-063722226LN2-GLP-1-PF-06372222
23.08Single5XEZNNC06405XEZ-Glucagon-NNC0640
23.08Single8XQSFlufenamic acid8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
21.43Single5XF1NNC06405XF1-Glucagon-NNC0640
17.65Single8TB7PubChem 1685102188TB7-GPR61-PubChem 168510218
15.38Single7EJX(1R;2R)-2-PCCA7EJX-GPR88-(1R;2R)-2-PCCA-Gi1/β1/γ2
14.29Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
11.11Single7DUQPubChem 1560227387DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
11.11Single8JR9PCO3718JR9-PTH1-PCO371-chim(NtGi1-Gs)/β1/γ2
8.33Single8XQPAristolochic acid A8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
8.33Single9JCPLPC9JCP-GPR4-LPC-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69Single5T1APubChem 120931705T1A-CCR2-BMS-681-PubChem 12093170
7.69Single8HNNSCH5467388HNN-CXCR3-SCH546738
7.69Single9JCOLPC9JCO-GPR4-LPC-chim(NtGi1-Gs)/β1/γ2
7.14Single8XQNAristolochic acid A8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
7.14Single8XQRFlufenamic acid8XQR-TAS2R14-Flufenamic acid-Gt3/β1/γ1
6.67Single5X7DCmpd-155X7D-β2-S-Carazolol-Cmpd-15
6.67Single8XQOAristolochic acid A8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
6.25Single7RBTLSN35566727RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
6.25Single8JPFSBI-5538JPF-NTS1-Neurotensin-SBI-553
6.25Single8XQLAristolochic acid A8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
5.88Single6LFLPubChem 1534669966LFL-CXCR2-PubChem 153466996
5.88Single8GW8PCO3718GW8-PTH1-PCO371-Gs/β1/γ2
5.56Single8J20AR4206268J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
5.26Single5LWEVercirnon5LWE-CCR9-Vercirnon
4.55Single8FN0SBI-5538FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2

PDB Summary
PDB 7EB2
Class C
SubFamily Aminoacid
Type GABAB
SubType GABAB2; GABAB1
Species Homo Sapiens
Ligand Baclofen
Other Ligand(s) rac-BHFF
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.5
Date 2021-05-05
D.O.I. doi.org/10.1038/s41586-021-03507-1
Net Summary
Imin 2.85
Number of Linked Nodes 2017
Number of Links 2433
Number of Hubs 379
Number of Links mediated by Hubs 1385
Number of Communities 81
Number of Nodes involved in Communities 541
Number of Links involved in Communities 733
Path Summary
Number Of Nodes in MetaPath 189
Number Of Links MetaPath 188
Number of Shortest Paths 3697571
Length Of Smallest Path 3
Average Path Length 43.8423
Length of Longest Path 114
Minimum Path Strength 1.235
Average Path Strength 5.58015
Maximum Path Strength 19.665
Minimum Path Correlation 0.7
Average Path Correlation 0.999412
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 4.7619
Average % Of Corr. Nodes 73.7985
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 44.3715
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• regulation of biological process   • signaling   • biological regulation   • cell-cell signaling   • neuron-glial cell signaling   • cellular process   • cell communication   • gamma-aminobutyric acid signaling pathway   • regulation of molecular function   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • negative regulation of molecular function   • negative regulation of catalytic activity   • negative regulation of adenylate cyclase activity   • trans-synaptic signaling   • synaptic signaling   • anterograde trans-synaptic signaling   • chemical synaptic transmission   • cellular response to stimulus   • regulation of cellular process   • response to stimulus   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • synaptic transmission, GABAergic   • cell periphery   • postsynapse   • cellular anatomical structure   • postsynaptic membrane   • synapse   • cell junction   • membrane   • plasma membrane   • plasma membrane region   • synaptic membrane   • protein-containing complex   • plasma membrane protein complex   • membrane protein complex   • receptor complex
Gene OntologyCellular Component• cell periphery   • postsynapse   • cellular anatomical structure   • postsynaptic membrane   • synapse   • cell junction   • membrane   • plasma membrane   • plasma membrane region   • synaptic membrane   • protein-containing complex   • plasma membrane protein complex   • membrane protein complex   • receptor complex   • GABA receptor complex   • G protein-coupled receptor dimeric complex   • plasma membrane signaling receptor complex   • G protein-coupled receptor complex   • G protein-coupled GABA receptor complex   • G protein-coupled receptor heterodimeric complex   • intracellular anatomical structure   • cytoplasm   • cell projection   • neuron projection   • plasma membrane bounded cell projection   • neurotransmitter receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • G protein-coupled neurotransmitter receptor activity   • G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential   • G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential   • postsynaptic neurotransmitter receptor activity   • neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential   • G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential   • protein binding   • binding   • extracellular matrix protein binding   • protein heterodimerization activity   • protein dimerization activity   • G protein-coupled GABA receptor activity   • GABA receptor activity   • developmental process   • multicellular organismal process   • cellular developmental process   • ossification   • cell differentiation   • cellular process   • osteoblast differentiation   • regulation of biological process   • signaling   • biological regulation   • cell-cell signaling   • neuron-glial cell signaling   • cell communication   • gamma-aminobutyric acid signaling pathway   • regulation of localization   • negative regulation of amino acid transport   • nitrogen compound transport   • negative regulation of amine transport   • transport   • negative regulation of biological process   • negative regulation of transport   • localization   • negative regulation of secretion   • gamma-aminobutyric acid transport   • negative regulation of gamma-aminobutyric acid secretion   • regulation of amino acid transport   • organic anion transport   • gamma-aminobutyric acid secretion   • carboxylic acid transport   • regulation of transport   • secretion   • regulation of gamma-aminobutyric acid secretion   • acid secretion   • establishment of localization   • regulation of secretion   • organic acid transport   • amino acid transport   • amine transport   • negative regulation of organic acid transport   • regulation of organic acid transport   • regulation of amine transport   • monoamine transport   • regulation of cellular process   • regulation of catecholamine secretion   • organic hydroxy compound transport   • dopamine transport   • secretion by cell   • regulation of secretion by cell   • catecholamine transport   • negative regulation of dopamine secretion   • signal release   • negative regulation of cellular process   • negative regulation of secretion by cell   • export from cell   • negative regulation of catecholamine secretion   • dopamine secretion   • catecholamine secretion   • regulation of dopamine secretion   • response to stimulus   • response to alcohol   • response to chemical   • response to oxygen-containing compound   • response to ethanol   • negative regulation of cell population proliferation   • cell population proliferation   • regulation of cell population proliferation   • epinephrine secretion   • epinephrine transport   • regulation of epinephrine secretion   • organic cation transport   • negative regulation of epinephrine secretion   • cellular response to stimulus   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • trans-synaptic signaling   • regulation of signaling   • negative regulation of signaling   • modulation of chemical synaptic transmission   • negative regulation of synaptic transmission   • negative regulation of cell communication   • chemical synaptic transmission   • synaptic signaling   • regulation of trans-synaptic signaling   • anterograde trans-synaptic signaling   • regulation of cell communication   • synaptic transmission, GABAergic   • response to nicotine   • positive regulation of cell communication   • regulation of hormone secretion   • regulation of peptide secretion   • positive regulation of biological process   • positive regulation of secretion by cell   • hormone secretion   • peptide secretion   • positive regulation of hormone secretion   • positive regulation of secretion   • amide transport   • regulation of biological quality   • regulation of peptide hormone secretion   • positive regulation of cellular process   • positive regulation of peptide secretion   • growth hormone secretion   • regulation of hormone levels   • regulation of growth hormone secretion   • regulation of peptide transport   • positive regulation of peptide hormone secretion   • peptide transport   • positive regulation of growth hormone secretion   • positive regulation of transport   • peptide hormone secretion   • hormone transport   • positive regulation of signaling   • regulation of glutamate secretion   • positive regulation of amine transport   • glutamate secretion   • positive regulation of glutamate secretion   • positive regulation of organic acid transport   • acidic amino acid transport   • positive regulation of amino acid transport   • dicarboxylic acid transport   • membrane-bounded organelle   • mitochondrial membrane   • mitochondrion   • intracellular membrane-bounded organelle   • intracellular organelle   • organelle envelope   • organelle   • mitochondrial envelope   • organelle membrane   • presynapse   • presynaptic membrane   • GABA-ergic synapse   • glutamatergic synapse   • organelle subcompartment   • endomembrane system   • endoplasmic reticulum subcompartment   • nuclear outer membrane-endoplasmic reticulum membrane network   • endoplasmic reticulum   • endoplasmic reticulum membrane   • somatodendritic compartment   • dendrite   • dendritic tree   • dendritic shaft   • neuron spine   • dendritic spine   • Schaffer collateral - CA1 synapse   • axon   • cell leading edge   • axolemma   • leading edge membrane   • neuron projection membrane   • main axon   • cell projection membrane   • cell body   • neuronal cell body   • extracellular region   • extracellular space   • transport vesicle   • intracellular vesicle   • cytoplasmic vesicle   • synaptic vesicle   • secretory vesicle   • vesicle   • exocytic vesicle   • G-protein beta-subunit binding   • fibroblast proliferation   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • extrinsic component of plasma membrane   • catalytic complex   • cytoplasmic side of membrane   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular membrane-bounded organelle   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • cellular response to acetylcholine   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • D2 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • enzyme regulator activity   • adenylate cyclase inhibitor activity   • cyclase regulator activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • molecular function regulator activity   • enzyme inhibitor activity   • adenylate cyclase regulator activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • response to peptide hormone   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • negative regulation of protein transport   • establishment of protein localization   • negative regulation of hormone secretion   • intracellular protein localization   • negative regulation of peptide hormone secretion   • establishment of protein localization to extracellular region   • negative regulation of establishment of protein localization   • protein secretion   • regulation of protein secretion   • negative regulation of protein secretion   • regulation of protein localization   • protein localization to extracellular region   • negative regulation of peptide secretion   • negative regulation of protein localization   • regulation of establishment of protein localization   • regulation of protein transport   • negative regulation of insulin secretion   • protein transport   • regulation of insulin secretion   • macromolecule localization   • insulin secretion   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • positive regulation of protein localization   • protein localization to cell cortex   • cellular response to forskolin   • response to forskolin   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • nucleoplasm   • Golgi apparatus   • ciliary basal body
SCOP2Domain Identifier• Type 1 solute binding protein-like   • Transducin (heterotrimeric G protein), gamma chain   • Galpha insert domain-like   • Ras-like P-loop GTPases
SCOP2Family Identifier• Type 1 solute binding protein-like   • Transducin (heterotrimeric G protein), gamma chain   • Galpha insert domain-like   • Ras-like P-loop GTPases
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
Code2C0
PDB ResiduesM:M:?1001
Environment DetailsOpen EMBL-EBI Page
Code2C0
NameArbaclofen
Synonyms(3R)-4-amino-3-(4-chlorophenyl)butanoic acid
Identifier
FormulaC10 H12 Cl N O2
Molecular Weight213.661
SMILES
PubChem44602
Formal Charge0
Total Atoms26
Total Chiral Atoms1
Total Bonds26
Total Aromatic Bonds6

CodeFN0
PDB ResiduesW:W:?901
Environment DetailsOpen EMBL-EBI Page
CodeFN0
Name(3S)-5,7-ditert-butyl-3-oxidanyl-3-(trifluoromethyl)-1-benzofuran-2-one
Synonyms
Identifier
FormulaC17 H21 F3 O3
Molecular Weight330.342
SMILES
PubChem7023848
Formal Charge0
Total Atoms44
Total Chiral Atoms1
Total Bonds45
Total Aromatic Bonds6

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>7EB2_Chain_A
CTLSAEDKA AVERSKMID RNLREDGEK AAREVKLLL LGAGESGKN 
TIVKQMKII HEAGYSEEE CKQYKAVVY SNTIQSIIA IIRAMGRLK 
IDFGDSARA DDARQLFVL AGAAEEGFM TAELAGVIK RLWKDSGVQ 
ACFNRSREY QLNDSAAYY LNDLDRIAQ PNYIPTQQD VLRTRVKTT 
GIVETHFTF KDLHFKMFD VGAQRSERK KWIHCFEGV TAIIFCVAL 
SDYDLVLAE DEEMNRMHA SMKLFDSIC NNKWFTDTS IILFLNKKD 
LFEEKIKKS PLTICYPEY AGSNTYEEA AAYIQCQFE DLNKRKDTK 
EIYTHFTCS TDTKNVQFV FDAVTDVII KNNLKDCGL F


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7EB2_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7EB2_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtO75899
Sequence
>7EB2_Chain_S
ERRAVYIGA LFPMSGGWP GGQACQPAV EMALEDVNS RRDILPDYE 
LKLIHHDSK CDPGQATKY LYELLYNDP IKIILMPGC SSVSTLVAE 
AARMWNLIV LSYGSSSPA LSNRQRFPT FFRTHPSAT LHNPTRVKL 
FEKWGWKKI ATIQQTTEV FTSTLDDLE ERVKEAGIE ITFRQSFFS 
DPAVPVKNL KRQDARIIV GLFYETEAR KVFCEVYKE RLFGKKYVW 
FLIGWYADN WFKIYDPSI NCTVDEMTE AVEGHITTE IVMLNPANT 
RSISNMTSQ EFVEKLTKR LKRHPEETG GFQEAPLAY DAIWALALA 
LNKTSRLED FNYNNQTIT DQIYRAMNS SSFEGVSGH VVFDASGSR 
MAWTLIEQL QGGSYKKIG YYDSTKDDL SWSKTDKWI GGSPPADQT 
LVIKTFRFL SQKLFISVS VLSSLGIVL AVVCLSFNI YNSHVRYIQ 
NSQPNLNNL TAVGCSLAL AAVFPLGLD GYHIGRNQF PFVCQARLW 
LLGLGFSLG YGSMFTKIW WVHTVFTLE PWKLYATVG LLVGMDVLT 
LAIWQIVDP LHRTIETFA KEEPKEDID VSILPQLEH CSSRKMNTW 
LGIFYGYKG LLLLLGIFL AYETKSVST EKINDHRAV GMAIYNVAV 
LCLITAPVT MILSSQQDA AFAFASLAI VFSSYITLV VLFVPKMRR 
LIT


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ9UBS5
Sequence
>7EB2_Chain_R
PLSIMGLMP LTKEVAKGS IGRGVLPAV ELAIEQIRN ESLLRPYFL 
DLRLYDTEC DNAKGLKAF YDAIKYGPN HLMVFGGVC PSVTSIIAE 
SLQGWNLVQ LSFAATTPV LADKKKYPY FFRTVPSDN AVNPAILKL 
LKHYQWKRV GTLTQDVQR FSEVRNDLT GVLYGEDIE ISDTESFSN 
DPCTSVKKL KGNDVRIIL GQFDQNMAA KVFCCAYEE NMYGSKYQW 
IIPGWYEPS WWEQVHRCL RKNLLAAME GYIGVDFEP LSSKQIKTI 
SGKTPQQYE REYNNKRSG VGPSKFHGY AYDGIWVIA KTLQRAMET 
LIQDFNYTD HTLGRIILN AMNETNFFG VTGQVVFRN GERMGTIKF 
TQFQDSREV KVGEYNAVA DTLEIINDT IRFQGSEPP KDKTIILEQ 
LRKISLPLY SILSALTIL GMIMASAFL FFNIKNRNQ KLIKMSSPY 
MNNLIILGG MLSYASIFL FGLDGSFVS EKTFETLCT VRTWILTVG 
YTTAFGAMF AKTWRVHAI FKNVKMKKK IIKDQKLLV IVGGMLLID 
LCILICWQA VDPLRRTVE KYSMEPDPA GRDISIRPL LEHCENTHM 
TIWLGIVYA YKGLLMLFG CFLAWETRN VSIPALNDS KYIGMSVYN 
VGIMCIIGA AVSFLTRDQ PNVQFCIVA LVIIFCSTI TLCLVFVPK 
LITLR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7CA3CAminoacidGABABGABAB1, GABAB2Homo sapiens-rac-BHFF-4.52020-11-11doi.org/10.1016/j.jmb.2020.09.023
7EB2CAminoacidGABABGABAB2; GABAB1Homo sapiensBaclofenrac-BHFFGi1/β1/γ23.52021-05-05doi.org/10.1038/s41586-021-03507-1
7EB2 (No Gprot) CAminoacidGABABGABAB2; GABAB1Homo sapiensBaclofenrac-BHFF3.52021-05-05doi.org/10.1038/s41586-021-03507-1
6WIVCAminoacidGABABGABAB1, GABAB2Homo sapiens-PubChem 52923113; PubChem 52924645-3.32020-07-01doi.org/10.1038/s41586-020-2452-0
6UO8CAminoacidGABABGABAB1, GABAB2Homo sapiensSKF97541GS39783-3.632020-06-10doi.org/10.1038/s41586-020-2408-4
7C7QCAminoacidGABABGABAB1, GABAB2Homo sapiensBaclofenBHFF-32020-07-01doi.org/10.1038/s41422-020-0350-5
6W2YCAminoacidGABABGABAB1; GABAB1Homo sapiensPubChem 5311042--3.22020-07-01doi.org/10.1038/s41586-020-2469-4
7CA5CAminoacidGABABGABAB1, GABAB2Homo sapiens---7.62020-11-11doi.org/10.1016/j.jmb.2020.09.023
7CUMCAminoacidGABABGABAB1, GABAB2Homo sapiensCGP54626--3.522020-11-11doi.org/10.1016/j.jmb.2020.09.023
7C7SCAminoacidGABABGABAB1, GABAB2Homo sapiensCGP54626--2.92020-07-01doi.org/10.1038/s41422-020-0350-5
6UO9CAminoacidGABABGABAB1, GABAB2Homo sapiensSKF97541--4.82020-06-10doi.org/10.1038/s41586-020-2408-4
6UOACAminoacidGABABGABAB1, GABAB2Homo sapiens---6.32020-06-10doi.org/10.1038/s41586-020-2408-4
6VJMCAminoacidGABABGABAB1, GABAB2Homo sapiens---3.972020-06-10doi.org/10.1038/s41586-020-2408-4
6W2XCAminoacidGABABGABAB1, GABAB2Homo sapiensPubChem 5311042--3.62020-07-01doi.org/10.1038/s41586-020-2469-4




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