Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1H:H:?1 32.4475460
2H:H:?4 21.745400
3H:H:?8 17.775400
4R:R:Y171 5.4725405
5R:R:L175 4.2075466
6R:R:F176 5.46767
7R:R:P177 2.0375467
8R:R:G184 2.9525405
9R:R:C188 2.6475465
10R:R:Q189 10.0275464
11R:R:M194 6.635467
12R:R:Y209 6.3085298
13R:R:E210 6.4425405
14R:R:L213 3.1975466
15R:R:K219 6.724305
16R:R:T226 5.1175417
17R:R:Y230 6.848517
18R:R:L233 6.3475417
19R:R:Y234 7.09667615
20R:R:I241 3.506517
21R:R:P244 2.82508
22R:R:V249 2.835408
23R:R:W260 6.52714717
24R:R:I263 2.805416
25R:R:S266 3.444548
26R:R:Y267 5.2625467
27R:R:S269 5.254548
28R:R:P272 4.02254167
29R:R:L274 6.39648
30R:R:F280 10.0425448
31R:R:F283 5.25333648
32R:R:F284 5.35667616
33R:R:R285 6.828549
34R:R:H287 5.752517
35R:R:P288 3.542516
36R:R:N294 6.94254169
37R:R:T296 5.0675428
38R:R:R297 11.298527
39R:R:L300 3.39426
40R:R:W304 10.9083627
41R:R:W306 8.194529
42R:R:I309 3.465428
43R:R:T311 3.4375427
44R:R:I312 3.38754326
45R:R:Q313 5.3875407
46R:R:Q314 6.97438
47R:R:F319 7.18833637
48R:R:L323 4.832526
49R:R:D325 6.7685166
50R:R:I337 6.0475406
51R:R:F339 11.5845216
52R:R:P347 3.6875406
53R:R:R360 6.202529
54R:R:I361 5.464529
55R:R:F366 4.084538
56R:R:E370 7.0275435
57R:R:R372 13.645437
58R:R:F375 5.736538
59R:R:Y379 10.1725407
60R:R:V389 4.8428
61R:R:W390 8.155439
62R:R:F391 4.80833627
63R:R:Y396 5.51833635
64R:R:W400 6.55143738
65R:R:C410 3.7725409
66R:R:V419 3.7975435
67R:R:H422 5.4275436
68R:R:T424 4.3725436
69R:R:R436 6.402561
70R:R:M441 6.015465
71R:R:S443 5.14434
72R:R:F446 6.6275467
73R:R:L450 4.26467
74R:R:P458 5.72403
75R:R:T461 4.764243
76R:R:G462 2.3554243
77R:R:F464 6.23407
78R:R:E466 5.7415
79R:R:L469 2.745416
80R:R:Y471 6.39714769
81R:R:W475 7.77568
82R:R:F498 3.79167618
83R:R:Y500 6.594518
84R:R:T506 2.815415
85R:R:I509 1.47416
86R:R:M513 4.9516
87R:R:F518 5.7425409
88R:R:F527 3.5925419
89R:R:D528 4.40254316
90R:R:R533 4.986519
91R:R:W536 5.285433
92R:R:Q541 6.0125429
93R:R:L542 4.6225434
94R:R:Q543 5.6025428
95R:R:Y547 4.108535
96R:R:I550 4.115427
97R:R:Y552 5.5425434
98R:R:Y553 7.715426
99R:R:D554 7.295435
100R:R:W562 6.02143725
101R:R:W568 6.774529
102R:R:P573 6425
103R:R:P574 3.982529
104R:R:R620 5.838508
105R:R:I622 5.4645129
106R:R:Q626 6.683336129
107R:R:P627 2.874129
108R:R:N630 4.9645129
109R:R:N631 5.825408
110R:R:C637 2.93254355
111R:R:V644 3.02408
112R:R:L649 8.40754345
113R:R:R666 10.5425408
114R:R:W668 6.04254386
115R:R:L670 4.29408
116R:R:Y678 5.875408
117R:R:F682 3.995479
118R:R:K684 3.52754129
119R:R:I685 2.735479
120R:R:W686 5.9475478
121R:R:W687 9.274579
122R:R:H689 6.115678
123R:R:Y711 3.824365
124R:R:V718 2.6475407
125R:R:W728 11.895259
126R:R:D732 5.9554258
127R:R:K747 4.19523
128R:R:S753 4.36422
129R:R:I754 4.004505
130R:R:Y774 4.466406
131R:R:Y776 7.31754397
132R:R:K777 4.895409
133R:R:L781 4.312508
134R:R:L783 3.25477
135R:R:L787 4.05479
136R:R:E790 8.044578
137R:R:T791 4.2225479
138R:R:D801 4.4354129
139R:R:Y810 9.29409
140R:R:I847 2.3854414
141R:R:F853 4.4985129
142R:R:K856 4.555129
143S:S:L56 5.0254426
144S:S:M59 7.3625417
145S:S:M62 3.558548
146S:S:P63 3.488548
147S:S:K70 3.975443
148S:S:Y97 7.224428
149S:S:R102 7.35412
150S:S:Y104 4.754516
151S:S:E107 6.7425445
152S:S:N110 4.9925445
153S:S:Y118 6.54143717
154S:S:I121 6.3625416
155S:S:P125 6.06417
156S:S:H127 6.75833618
157S:S:M129 3.655406
158S:S:F131 4.51447
159S:S:G132 2.606549
160S:S:V134 3.25446
161S:S:C135 4.335446
162S:S:V138 3.1975448
163S:S:W149 5.42833617
164S:S:L154 2.9925447
165S:S:F156 5.76446
166S:S:T160 3.7154148
167S:S:L163 4.5385148
168S:S:Y169 7.46254147
169S:S:Y171 4.34646
170S:S:F172 4.8185148
171S:S:F173 4.11167647
172S:S:R174 4.1925149
173S:S:P177 3.598336106
174S:S:N183 4.028509
175S:S:L189 3.24754176
176S:S:W195 8.91167689
177S:S:V198 3.485488
178S:S:Q203 7.9675457
179S:S:R207 5.7875455
180S:S:F208 6.24457
181S:S:R212 6.166445
182S:S:S227 5.545484
183S:S:F232 5.98457
184S:S:P236 5.70333655
185S:S:L243 4.6488
186S:S:V248 3.985487
187S:S:R249 8.5175489
188S:S:I250 6.302589
189S:S:Q254 5.87406
190S:S:F255 4.146558
191S:S:M259 6.05454
192S:S:F264 5.595457
193S:S:C265 4.09754229
194S:S:Y268 6.925406
195S:S:E270 11.84254455
196S:S:Y273 7.725405
197S:S:K276 12.42254187
198S:S:W279 9.915409
199S:S:I281 4.70333656
200S:S:W284 3.868556
201S:S:Y285 5.44286755
202S:S:W289 5.12778959
203S:S:W290 9.3025456
204S:S:C302 5.64229
205S:S:N306 4.5765226
206S:S:M311 4.7525455
207S:S:Y314 5.68667655
208S:S:F319 5.76754104
209S:S:S331 3.9145138
210S:S:Y338 4.775137
211S:S:Y342 18.3654267
212S:S:N343 7.8854263
213S:S:R346 8.2265264
214S:S:V349 3.1475401
215S:S:P351 3.95254263
216S:S:F354 4.2145105
217S:S:Y357 5.6125105
218S:S:Y359 5.971437139
219S:S:D360 3.336509
220S:S:W363 9.01254138
221S:S:F388 3.034437
222S:S:Y390 5.41418
223S:S:M403 5.908545
224S:S:F408 4.4825409
225S:S:F409 2.78402
226S:S:R422 5.341676109
227S:S:M423 5.1975405
228S:S:F428 3.355178
229S:S:F431 4.455655
230S:S:E436 7.5975454
231S:S:G440 2.002507
232S:S:Y442 3.9325176
233S:S:L449 4.29754177
234S:S:R475 7.99754204
235S:S:Y482 5.165405
236S:S:F502 1.8025406
237S:S:M514 9.642597
238S:S:S515 5.7499
239S:S:Y518 8.47754115
240S:S:N520 8.55499
241S:S:N521 7.84118
242S:S:I524 6.1554117
243S:S:L525 4.8154113
244S:S:G526 1.945119
245S:S:Y531 7.108508
246S:S:F535 7.735406
247S:S:T566 2.6085117
248S:S:K574 6.285699
249S:S:R577 6.76509
250S:S:H579 5.9675478
251S:S:K583 4.61333677
252S:S:V601 2.5654477
253S:S:D608 5.3454279
254S:S:W615 13.65754159
255S:S:D619 9.06254159
256S:S:L621 5.4045156
257S:S:Y628 5.99404
258S:S:E631 7.2854195
259S:S:R642 10.5845194
260S:S:L645 5.35754205
261S:S:H647 8.97754205
262S:S:N650 5.644158
263S:S:M653 14.274155
264S:S:W656 11.18676158
265S:S:Y663 5.0454275
266S:S:M668 3.96754238
267S:S:F670 4.8625407
268S:S:F673 4.0525479
269S:S:L674 3.3625409
270S:S:I683 5.225497
271S:S:D688 8.4175499
272S:S:S689 3.855499
273S:S:V699 2.122509
274S:S:R714 5.454203
275S:S:F721 4.2125407
276S:S:I729 2.3575406
277S:S:F740 6.65699
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:I240 R:R:I241 10.66454.42NoYes157
2R:R:F498 R:R:I240 13.51566.28YesNo185
3R:R:Y230 S:S:W149 13.65916.75YesYes177
4S:S:L151 S:S:W149 12.06023.42NoYes077
5S:S:L400 S:S:Y171 10.18655.86NoYes436
6S:S:F173 S:S:L400 10.43942.44YesNo473
7R:R:F498 R:R:Y500 10.71465.16YesYes188
8R:R:L274 R:R:R285 47.78546.07YesYes489
9R:R:F280 R:R:L274 96.69037.31YesYes488
10R:R:E255 R:R:F280 97.57187NoYes488
11R:R:E255 S:S:N110 97.64865.26NoYes485
12R:R:F527 R:R:R533 11.66332.14YesYes199
13R:R:L274 R:R:S271 46.97839.01YesNo089
14R:R:P272 R:R:S271 46.91823.56YesNo079
15R:R:P272 R:R:T322 46.78491.75YesNo1677
16R:R:R285 R:R:S289 53.4026.59YesNo098
17R:R:S289 R:R:T291 53.38443.2NoNo086
18R:R:N294 R:R:T291 53.21212.92YesNo1696
19R:R:N294 R:R:T322 46.77064.39YesNo1697
20R:R:L326 R:R:N294 10013.73NoYes089
21R:R:L326 R:R:R297 97.996719.44NoYes087
22R:R:R297 R:R:V363 12.545615.69YesNo077
23R:R:I309 R:R:R297 82.26582.51YesYes287
24R:R:I309 R:R:I361 82.02854.42YesYes289
25R:R:I361 R:R:R360 83.71132.51YesYes299
26R:R:G364 R:R:V363 12.36421.84NoNo067
27R:R:Q577 R:R:R360 83.681614.02NoYes259
28R:R:Q577 R:R:S753 83.77751.44NoYes252
29R:R:L579 R:R:S753 82.40314.5NoYes032
30R:R:I581 R:R:L579 82.35262.85NoNo023
31R:R:I581 R:R:Q757 81.7974.12NoNo025
32R:R:I738 R:R:Q757 81.59388.23NoNo045
33R:R:E759 R:R:I738 80.81172.73NoNo3774
34R:R:E759 R:R:F659 80.880813.99NoNo074
35R:R:F659 R:R:V662 80.72775.24NoNo045
36R:R:P646 R:R:V662 80.67661.77NoNo065
37R:R:P646 R:R:R666 80.57444.32NoYes068
38R:R:L670 R:R:R666 79.03399.72YesYes088
39R:R:A643 R:R:L670 78.25861.58NoYes088
40R:R:A643 R:R:L669 78.20671.58NoNo085
41R:R:L669 R:R:W668 78.15495.69NoYes056
42R:R:L725 R:R:W668 70.26536.83NoYes3886
43R:R:L725 R:R:T724 70.22072.95NoNo086
44R:R:F773 R:R:T724 70.16725.19NoNo066
45R:R:F773 R:R:K777 70.11388.69NoYes069
46R:R:F674 R:R:K777 69.43613.72NoYes099
47R:R:F674 R:R:Y678 69.38376.19NoYes098
48R:R:F682 R:R:Y678 67.98633.09YesYes098
49R:R:F682 R:R:L783 67.10164.87YesYes797
50R:R:L783 S:S:F673 66.37593.65YesYes779
51R:R:F786 S:S:F673 67.65544.29NoYes099
52R:R:F786 S:S:F670 67.47816.43NoYes097
53S:S:N110 S:S:V138 97.59034.43YesYes458
54S:S:C108 S:S:V138 31.36143.42NoYes478
55S:S:C108 S:S:T106 31.33571.69NoNo078
56S:S:P63 S:S:T106 31.31073.5YesNo088
57S:S:M62 S:S:P63 62.60985.03YesYes488
58S:S:C135 S:S:V138 66.25081.71YesYes468
59S:S:C135 S:S:K70 65.07656.47YesYes463
60S:S:K70 S:S:P63 31.5423.35YesYes438
61S:S:K70 S:S:V134 33.85983.04YesYes436
62S:S:M62 S:S:V134 31.43723.04YesYes486
63S:S:F156 S:S:M62 46.21446.22YesYes468
64S:S:F131 S:S:G132 46.21514.52YesYes479
65S:S:F173 S:S:L154 81.16392.44YesYes477
66S:S:F131 S:S:L154 84.73152.44YesYes477
67S:S:F173 S:S:G420 85.8674.52YesNo078
68S:S:E421 S:S:G420 85.5021.64NoNo078
69S:S:E421 S:S:M423 85.31962.71NoYes075
70S:S:A444 S:S:M423 84.22624.83NoYes045
71S:S:A444 S:S:Y442 84.04434NoYes046
72S:S:I426 S:S:Y442 37.02522.42NoYes1756
73S:S:F428 S:S:I426 36.84512.51YesNo1785
74S:S:F428 S:S:V317 62.80453.93YesNo086
75S:S:V182 S:S:V317 15.61493.21NoNo056
76S:S:N183 S:S:V182 15.24322.96YesNo095
77S:S:L449 S:S:Y442 46.28592.34YesYes1776
78S:S:F428 S:S:L449 36.84633.65YesYes1787
79S:S:G316 S:S:V317 46.82931.84NoNo056
80S:S:G316 S:S:T429 36.79711.82NoNo055
81S:S:E436 S:S:T429 36.426311.29YesNo045
82S:S:E436 S:S:Y314 13.38114.59YesYes545
83S:S:E436 S:S:W289 11.89372.18YesYes549
84S:S:F428 S:S:G440 10.96263.01YesYes087
85S:S:E436 S:S:F431 10.78142.33YesYes545
86S:S:F670 S:S:W576 66.71974.01YesNo078
87S:S:R577 S:S:W576 69.94143YesNo098
88S:S:L597 S:S:R577 69.648924.3NoYes089
89S:S:D594 S:S:L597 69.59044.07NoNo088
90S:S:D594 S:S:S516 69.3565.89NoNo089
91S:S:M519 S:S:S516 69.23873.07NoNo069
92S:S:M519 S:S:S515 34.05796.13NoYes969
93S:S:M514 S:S:S515 33.92874.6YesYes979
94S:S:M514 S:S:N520 35.981614.02YesYes979
95S:S:F740 S:S:N520 31.72213.62YesYes999
96S:S:F499 S:S:F740 55.49657.5NoYes079
97S:S:F499 S:S:M495 53.10877.46NoNo074
98S:S:G492 S:S:M495 52.84331.75NoNo084
99S:S:G492 S:S:Y531 52.31254.35NoYes088
100S:S:S732 S:S:Y531 47.250816.53NoYes088
101S:S:G527 S:S:S732 46.73541.86NoNo058
102S:S:G526 S:S:G527 46.46962.11YesNo095
103S:S:G526 S:S:G563 39.01162.11YesNo1199
104S:S:G563 S:S:L529 38.75871.71NoNo095
105S:S:I559 S:S:L529 38.49242.85NoNo045
106S:S:I559 S:S:W558 37.693714.09NoNo046
107S:S:V555 S:S:W558 36.89482.45NoNo066
108S:S:L552 S:S:V555 36.36228.94NoNo046
109S:S:F549 S:S:L552 36.095814.61NoNo044
110S:S:D540 S:S:F549 35.29675.97NoNo084
111S:S:D540 S:S:G541 17.12995.03NoNo085
112S:S:E646 S:S:G541 16.86261.64NoNo065
113S:S:K574 S:S:M519 35.12227.2YesNo996
114S:S:K574 S:S:M514 33.99035.76YesYes997
115S:S:K743 S:S:M514 31.85047.2NoYes097
116S:S:F740 S:S:K743 31.7198.69YesNo099
117S:S:D540 S:S:R556 17.93219.53NoNo087
118S:S:F537 S:S:R556 17.13047.48NoNo057
119S:S:F537 S:S:F721 16.86316.43NoYes057
120S:S:F721 S:S:Q720 10.44612.34YesNo075
121S:S:L736 S:S:T735 10.83874.42NoNo078
122S:S:T735 S:S:V699 10.43751.59NoYes089
123S:S:G132 S:S:M62 47.24531.75YesYes498
124S:S:F131 S:S:F156 45.73158.57YesYes476
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 6VJM
Class C
SubFamily Aminoacid
Type GABAB
SubType GABAB1; GABAB2
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners -
PDB Resolution 3.97
Date 2020-06-10
D.O.I. doi.org/10.1038/s41586-020-2408-4
Net Summary
Imin 1.64
Number of Linked Nodes 1306
Number of Links 1648
Number of Hubs 277
Number of Links mediated by Hubs 984
Number of Communities 48
Number of Nodes involved in Communities 443
Number of Links involved in Communities 640
Path Summary
Number Of Nodes in MetaPath 125
Number Of Links MetaPath 124
Number of Shortest Paths 17840278
Length Of Smallest Path 3
Average Path Length 61.4737
Length of Longest Path 109
Minimum Path Strength 1.145
Average Path Strength 5.59728
Maximum Path Strength 41.05
Minimum Path Correlation 0.75
Average Path Correlation 1
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.32558
Average % Of Corr. Nodes 39.421
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 61.9114
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• regulation of biological process   • signaling   • biological regulation   • cell-cell signaling   • neuron-glial cell signaling   • cellular process   • cell communication   • gamma-aminobutyric acid signaling pathway   • regulation of molecular function   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • negative regulation of molecular function   • negative regulation of catalytic activity   • negative regulation of adenylate cyclase activity   • trans-synaptic signaling   • synaptic signaling   • anterograde trans-synaptic signaling   • chemical synaptic transmission   • cellular response to stimulus   • regulation of cellular process   • response to stimulus   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • synaptic transmission, GABAergic   • cell periphery   • postsynapse   • cellular anatomical structure   • postsynaptic membrane   • synapse   • cell junction   • membrane   • plasma membrane   • plasma membrane region   • synaptic membrane   • protein-containing complex   • plasma membrane protein complex   • membrane protein complex   • receptor complex
Gene OntologyCellular Component• cell periphery   • postsynapse   • cellular anatomical structure   • postsynaptic membrane   • synapse   • cell junction   • membrane   • plasma membrane   • plasma membrane region   • synaptic membrane   • protein-containing complex   • plasma membrane protein complex   • membrane protein complex   • receptor complex   • GABA receptor complex   • G protein-coupled receptor dimeric complex   • plasma membrane signaling receptor complex   • G protein-coupled receptor complex   • G protein-coupled GABA receptor complex   • G protein-coupled receptor heterodimeric complex   • intracellular anatomical structure   • cytoplasm   • cell projection   • neuron projection   • plasma membrane bounded cell projection   • neurotransmitter receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • G protein-coupled neurotransmitter receptor activity   • G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential   • G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential   • postsynaptic neurotransmitter receptor activity   • neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential   • G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential   • protein binding   • binding   • extracellular matrix protein binding   • protein heterodimerization activity   • protein dimerization activity   • G protein-coupled GABA receptor activity   • GABA receptor activity   • developmental process   • multicellular organismal process   • cellular developmental process   • ossification   • cell differentiation   • cellular process   • osteoblast differentiation   • regulation of biological process   • signaling   • biological regulation   • cell-cell signaling   • neuron-glial cell signaling   • cell communication   • gamma-aminobutyric acid signaling pathway   • regulation of localization   • negative regulation of amino acid transport   • nitrogen compound transport   • negative regulation of amine transport   • transport   • negative regulation of biological process   • negative regulation of transport   • localization   • negative regulation of secretion   • gamma-aminobutyric acid transport   • negative regulation of gamma-aminobutyric acid secretion   • regulation of amino acid transport   • organic anion transport   • gamma-aminobutyric acid secretion   • carboxylic acid transport   • regulation of transport   • secretion   • regulation of gamma-aminobutyric acid secretion   • acid secretion   • establishment of localization   • regulation of secretion   • organic acid transport   • amino acid transport   • amine transport   • negative regulation of organic acid transport   • regulation of organic acid transport   • regulation of amine transport   • monoamine transport   • regulation of cellular process   • regulation of catecholamine secretion   • organic hydroxy compound transport   • dopamine transport   • secretion by cell   • regulation of secretion by cell   • catecholamine transport   • negative regulation of dopamine secretion   • signal release   • negative regulation of cellular process   • negative regulation of secretion by cell   • export from cell   • negative regulation of catecholamine secretion   • dopamine secretion   • catecholamine secretion   • regulation of dopamine secretion   • response to stimulus   • response to alcohol   • response to chemical   • response to oxygen-containing compound   • response to ethanol   • negative regulation of cell population proliferation   • cell population proliferation   • regulation of cell population proliferation   • epinephrine secretion   • epinephrine transport   • regulation of epinephrine secretion   • organic cation transport   • negative regulation of epinephrine secretion   • cellular response to stimulus   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • trans-synaptic signaling   • regulation of signaling   • negative regulation of signaling   • modulation of chemical synaptic transmission   • negative regulation of synaptic transmission   • negative regulation of cell communication   • chemical synaptic transmission   • synaptic signaling   • regulation of trans-synaptic signaling   • anterograde trans-synaptic signaling   • regulation of cell communication   • synaptic transmission, GABAergic   • response to nicotine   • positive regulation of cell communication   • regulation of hormone secretion   • regulation of peptide secretion   • positive regulation of biological process   • positive regulation of secretion by cell   • hormone secretion   • peptide secretion   • positive regulation of hormone secretion   • positive regulation of secretion   • amide transport   • regulation of biological quality   • regulation of peptide hormone secretion   • positive regulation of cellular process   • positive regulation of peptide secretion   • growth hormone secretion   • regulation of hormone levels   • regulation of growth hormone secretion   • regulation of peptide transport   • positive regulation of peptide hormone secretion   • peptide transport   • positive regulation of growth hormone secretion   • positive regulation of transport   • peptide hormone secretion   • hormone transport   • positive regulation of signaling   • regulation of glutamate secretion   • positive regulation of amine transport   • glutamate secretion   • positive regulation of glutamate secretion   • positive regulation of organic acid transport   • acidic amino acid transport   • positive regulation of amino acid transport   • dicarboxylic acid transport   • membrane-bounded organelle   • mitochondrial membrane   • mitochondrion   • intracellular membrane-bounded organelle   • intracellular organelle   • organelle envelope   • organelle   • mitochondrial envelope   • organelle membrane   • presynapse   • presynaptic membrane   • GABA-ergic synapse   • glutamatergic synapse   • organelle subcompartment   • endomembrane system   • endoplasmic reticulum subcompartment   • nuclear outer membrane-endoplasmic reticulum membrane network   • endoplasmic reticulum   • endoplasmic reticulum membrane   • somatodendritic compartment   • dendrite   • dendritic tree   • dendritic shaft   • neuron spine   • dendritic spine   • Schaffer collateral - CA1 synapse   • axon   • cell leading edge   • axolemma   • leading edge membrane   • neuron projection membrane   • main axon   • cell projection membrane   • cell body   • neuronal cell body   • extracellular region   • extracellular space   • transport vesicle   • intracellular vesicle   • cytoplasmic vesicle   • synaptic vesicle   • secretory vesicle   • vesicle   • exocytic vesicle
SCOP2Domain Identifier• Type 1 solute binding protein-like
SCOP2Family Identifier• Type 1 solute binding protein-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeNAG
PDB ResiduesH:H:?1 H:H:?2 H:H:?4 H:H:?5 H:H:?6 H:H:?7 H:H:?8 H:H:?9 H:H:?10 H:H:?11
Environment DetailsOpen EMBL-EBI Page
CodeNAG
NameN-Acetylglucosamine
SynonymsN-Acetylglucosamine
Identifier
FormulaC8 H15 N O6
Molecular Weight221.208
SMILES
PubChem24139
Formal Charge0
Total Atoms30
Total Chiral Atoms5
Total Bonds30
Total Aromatic Bonds0

CodeFUC
PDB ResiduesH:H:?3
Environment DetailsOpen EMBL-EBI Page
CodeFUC
Namealpha-L-fucose
Synonymsalpha-L-fucose; 6-deoxy-alpha-L-galactopyranose; L-fucose; fucose
Identifier
FormulaC6 H12 O5
Molecular Weight164.156
SMILES
PubChem439554
Formal Charge0
Total Atoms23
Total Chiral Atoms5
Total Bonds23
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ9UBS5
Sequence
>6VJM_Chain_R
SERRAVYIG ALFPMSGGW PGGQACQPA VEMALEDVN SRRDILPDY 
ELKLIHHDS KCDPGQATK YLYELLYND PIKIILMPG CSSVSTLVA 
EAARMWNLI VLSYGSSSP ALSNRQRFP TFFRTHPSA TLHNPTRVK 
LFEKWGWKK IATIQQTTE VFTSTLDDL EERVKEAGI EITFRQSFF 
SDPAVPVKN LKRQDARII VGLFYETEA RKVFCEVYK ERLFGKKYV 
WFLIGWYAD NWFKIYDPS INCTVDEMT EAVEGHITT EIVMLNPAN 
TRSISNMTS QEFVEKLTK RLKRHPEET GGFQEAPLA YDAIWALAL 
ALNKTSRLE DFNYNNQTI TDQIYRAMN SSSFEGVSG HVVFDASGS 
RMAWTLIEQ LQGGSYKKI GYYDSTKDD LSWSKTDKW IGGSPPADQ 
TLVIKTFRF LSQKLFISV SVLSSLGIV LAVVCLSFN IYNSHVRYI 
QNSQPNLNN LTAVGCSLA LAAVFPLGL DGYHIGRNQ FPFVCQARL 
WLLGLGFSL GYGSMFTKI WWVHTVFTK KRKTLEPWK LYATVGLLV 
GMDVLTLAI WQIVDPLHR TIETFAKEE PKEDIDVSI LPQLEHCSS 
RKMNTWLGI FYGYKGLLL LLGIFLAYE TKSVSTEKI NDHRAVGMA 
IYNVAVLCL ITAPVTMIL SSQQDAAFA FASLAIVFS SYITLVVLF 
VPKMRRLIT


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtO75899
Sequence
>6VJM_Chain_S
SPPLSIMGL MPLTKEVAK GSIGRGVLP AVELAIEQI RNESLLRPY 
FLDLRLYDT ECDNAKGLK AFYDAIKYG PNHLMVFGG VCPSVTSII 
AESLQGWNL VQLSFAATT PVLADKKKY PYFFRTVPS DNAVNPAIL 
KLLKHYQWK RVGTLTQDV QRFSEVRND LTGVLYGED IEISDTESF 
SNDPCTSVK KLKGNDVRI ILGQFDQNM AAKVFCCAY EENMYGSKY 
QWIIPGWYE PSWWEQSRC LRKNLLAAM EGYIGVDFE PLSSKQIKT 
ISGKTPQQY EREYNNKRS GVGPSKFHG YAYDGIWVI AKTLQRAME 
TLHASIQDF NYTDHTLGR IILNAMNET NFFGVTGQV VFRNGERMG 
TIKFTQFQD SREVKVGEY NAVADTLEI INDTIRFQG SEPPKDKTI 
ILEQLRKIS LPLYSILSA LTILGMIMA SAFLFFNIK NRNQKLIKM 
SSPYMNNLI ILGGMLSYA SIFLFGLDG SFVSEKTFE TLCTVRTWI 
LTVGYTTAF GAMFAKTWR VHAIFKNVK MKKKIIKDQ KLLVIVGGM 
LLIDLCILI CWQAVDPLR RTVEKYSME PDPAGRDIS IRPLLEHCE 
NTHMTIWLG IVYAYKGLL MLFGCFLAW ETRNVSIPA LNDSKYIGM 
SVYNVGIMC IIGAAVSFL TRDQPNVQF CIVALVIIF CSTITLCLV 
FVPKLITLR T


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7CA3CAminoacidGABABGABAB1, GABAB2Homo sapiens-rac-BHFF-4.52020-11-11doi.org/10.1016/j.jmb.2020.09.023
7EB2CAminoacidGABABGABAB2; GABAB1Homo sapiensBaclofenrac-BHFFGi1/β1/γ23.52021-05-05doi.org/10.1038/s41586-021-03507-1
7EB2 (No Gprot) CAminoacidGABABGABAB2; GABAB1Homo sapiensBaclofenrac-BHFF3.52021-05-05doi.org/10.1038/s41586-021-03507-1
6WIVCAminoacidGABABGABAB1, GABAB2Homo sapiens-PubChem 52923113; PubChem 52924645-3.32020-07-01doi.org/10.1038/s41586-020-2452-0
6UO8CAminoacidGABABGABAB1, GABAB2Homo sapiensSKF97541GS39783-3.632020-06-10doi.org/10.1038/s41586-020-2408-4
7C7QCAminoacidGABABGABAB1, GABAB2Homo sapiensBaclofenBHFF-32020-07-01doi.org/10.1038/s41422-020-0350-5
6W2YCAminoacidGABABGABAB1; GABAB1Homo sapiensPubChem 5311042--3.22020-07-01doi.org/10.1038/s41586-020-2469-4
7CA5CAminoacidGABABGABAB1, GABAB2Homo sapiens---7.62020-11-11doi.org/10.1016/j.jmb.2020.09.023
7CUMCAminoacidGABABGABAB1, GABAB2Homo sapiensCGP54626--3.522020-11-11doi.org/10.1016/j.jmb.2020.09.023
7C7SCAminoacidGABABGABAB1, GABAB2Homo sapiensCGP54626--2.92020-07-01doi.org/10.1038/s41422-020-0350-5
6UO9CAminoacidGABABGABAB1, GABAB2Homo sapiensSKF97541--4.82020-06-10doi.org/10.1038/s41586-020-2408-4
6UOACAminoacidGABABGABAB1, GABAB2Homo sapiens---6.32020-06-10doi.org/10.1038/s41586-020-2408-4
6W2XCAminoacidGABABGABAB1, GABAB2Homo sapiensPubChem 5311042--3.62020-07-01doi.org/10.1038/s41586-020-2469-4




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Download 6VJM.zip



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