Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:Y171 11.9267665
2R:R:F176 15.4175437
3R:R:Q189 12.086534
4R:R:V192 4.805437
5R:R:L196 8.225436
6R:R:V199 5.5075437
7R:R:Y209 8.766508
8R:R:E210 6.7225435
9R:R:L211 9.8625439
10R:R:I214 11.525463
11R:R:K227 8.3775407
12R:R:Y230 10.7083667
13R:R:L233 9.31467
14R:R:P237 8.795466
15R:R:K239 9.3325467
16R:R:I240 6.70254235
17R:R:I241 11.5954237
18R:R:V249 4.4325408
19R:R:W260 6.74571767
20R:R:Y267 7.721676257
21R:R:F283 9.75667608
22R:R:H287 7.2125407
23R:R:H293 7.545615
24R:R:N294 6.9725419
25R:R:P295 6.2975413
26R:R:R297 10.324517
27R:R:F301 15.8925416
28R:R:W304 10.1529717
29R:R:W306 18.0417619
30R:R:K308 11.04407
31R:R:Q314 10.7485148
32R:R:F319 9.9245157
33R:R:D325 9.1325416
34R:R:R329 7.45875814
35R:R:V330 7.855417
36R:R:I335 7.7525417
37R:R:F339 14.10754276
38R:R:F343 8.1756147
39R:R:R360 11.6025419
40R:R:I361 11.318519
41R:R:V363 7.1575417
42R:R:F366 9.5525148
43R:R:E370 13.78254145
44R:R:F375 7.3465108
45R:R:Y379 9.75254307
46R:R:F384 6.0375405
47R:R:F391 10.4017617
48R:R:Y396 6.413336105
49R:R:D405 8.70254293
50R:R:H422 8.1425406
51R:R:I423 8.4475416
52R:R:T424 4.77254106
53R:R:T425 9.085416
54R:R:V428 5.35254315
55R:R:S437 5.455437
56R:R:M441 3.655435
57R:R:L454 5.055324
58R:R:Y471 9.18167639
59R:R:I474 5.58833636
60R:R:W475 10.9438
61R:R:Y500 10.39468
62R:R:V521 5.07538
63R:R:R533 4.9025409
64R:R:W536 6.85254313
65R:R:T537 10.84416
66R:R:I539 6.274517
67R:R:E540 11.405406
68R:R:L542 4.534297104
69R:R:Q543 7.975418
70R:R:I550 9.245417
71R:R:Y552 4.794504
72R:R:Y553 15.15516
73R:R:D558 8.3925414
74R:R:L560 7.8125417
75R:R:W562 8.644515
76R:R:W568 11.63619
77R:R:P573 6.8925415
78R:R:D576 15.73419
79R:R:I581 9.19254212
80R:R:V595 3.0454346
81R:R:L605 5.6825404
82R:R:F612 5.8025408
83R:R:Y615 7.0254132
84R:R:I622 12.51754139
85R:R:Q623 11.00254138
86R:R:L632 9.2075406
87R:R:L639 5.41406
88R:R:V644 7.2254178
89R:R:L649 10.14754345
90R:R:Y652 15.54574
91R:R:F661 10.14401
92R:R:R666 5.6525478
93R:R:L672 5.5925405
94R:R:L710 4.1225408
95R:R:W728 15.32479
96R:R:V731 4.26833674
97R:R:L734 4.5775476
98R:R:H735 9.2775474
99R:R:K743 6.5325401
100R:R:L758 8.4654335
101R:R:M766 4.335475
102R:R:L770 11.465475
103R:R:I785 5.855406
104R:R:F786 14.7409
105R:R:L815 5.09407
106R:R:F834 7.7845357
107R:R:I841 5.92254367
108R:R:Y846 8.77408
109R:R:L852 3.2525407
110R:R:M857 10.0854136
111R:R:I861 11.67254134
112R:R:T862 5.5185134
113S:S:P54 4.15754373
114S:S:M62 10.23254118
115S:S:P63 7.4325118
116S:S:L64 6.7775405
117S:S:T65 12.54254115
118S:S:V68 5.95254112
119S:S:I73 4.984394
120S:S:V77 3.8825405
121S:S:Q87 8.9675457
122S:S:R102 14.424382
123S:S:N110 8.50754205
124S:S:L114 5.7354206
125S:S:Y118 7.942567
126S:S:H127 6.156508
127S:S:C135 4.845406
128S:S:E144 5.8875407
129S:S:L146 6.79597
130S:S:W149 12.968507
131S:S:Q153 8.4225499
132S:S:L154 5.92447
133S:S:F156 8.3325446
134S:S:K168 7.3925405
135S:S:F172 8.6675498
136S:S:R174 8.412599
137S:S:T175 7.275447
138S:S:V176 5.242546
139S:S:V182 5.9025445
140S:S:N183 11.1245189
141S:S:L187 7.5854185
142S:S:Y193 9.135688
143S:S:W195 11.706589
144S:S:Q203 9.59427
145S:S:F208 9.368527
146S:S:D214 5.914405
147S:S:V218 8.4654183
148S:S:E222 7.7785185
149S:S:Q254 11.9475426
150S:S:F255 7.948528
151S:S:F264 9.23727
152S:S:E269 6.864195
153S:S:E270 6.9054225
154S:S:M272 5.2285227
155S:S:Y277 6.6854228
156S:S:Q278 9.47488
157S:S:I281 10.5875426
158S:S:P282 6.54405
159S:S:W284 11.535426
160S:S:Y285 9.62525
161S:S:W289 9.114529
162S:S:W290 15.7433626
163S:S:L307 4.845427
164S:S:M311 9.965425
165S:S:E312 8.1065427
166S:S:Y314 11.55525
167S:S:I315 9.1485
168S:S:E320 9.1625164
169S:S:T329 8.03557
170S:S:I330 6.505405
171S:S:S331 7.405458
172S:S:K333 9.51455
173S:S:Y338 13.5557
174S:S:E339 6.1275452
175S:S:Y342 15.6925457
176S:S:R346 4.584554
177S:S:G350 3.5325453
178S:S:P351 6.128553
179S:S:Y357 6.896505
180S:S:Y359 9.41759
181S:S:I362 7.052556
182S:S:W363 8.09408
183S:S:M373 6.22504
184S:S:L395 9.815446
185S:S:I399 5.0425446
186S:S:M403 7.155445
187S:S:E405 7.325405
188S:S:F417 10.6325449
189S:S:R422 5.89571749
190S:S:M423 3.7075405
191S:S:I426 9.6025445
192S:S:K427 8.9854165
193S:S:Q430 7.285489
194S:S:Q432 8.4025407
195S:S:D433 6.8925423
196S:S:V437 5.915484
197S:S:V439 6.65586
198S:S:E441 10.32254164
199S:S:Y442 12.4875446
200S:S:E462 7.46754433
201S:S:D466 6.8925409
202S:S:I477 6.8225407
203S:S:Y482 5.235405
204S:S:L485 7.375405
205S:S:L500 2.795408
206S:S:Y518 6.46833605
207S:S:N520 6.4585459
208S:S:I523 4.975458
209S:S:I534 8.22754468
210S:S:F535 5.69406
211S:S:F537 9.84254475
212S:S:E550 4.185403
213S:S:W558 11.966126
214S:S:Y564 8.915469
215S:S:M604 3.4775406
216S:S:I611 6.1454126
217S:S:H652 9.99254124
218S:S:W656 9.3265128
219S:S:Y663 5.16754125
220S:S:K664 3.77754509
221S:S:F673 11.0375409
222S:S:I692 6.55754488
223S:S:V709 6.885406
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:E210 R:R:N200 33.78995.26YesNo359
2R:R:A169 R:R:E210 33.78613.02NoYes035
3R:R:A169 R:R:K212 33.78193.21NoNo033
4R:R:I172 R:R:L211 67.662215.7NoYes089
5R:R:G173 R:R:I172 68.20261.76NoNo078
6R:R:G173 R:R:I214 68.21261.76NoYes073
7R:R:I214 R:R:Y171 34.126826.59YesYes635
8R:R:I214 R:R:L232 34.10587.14YesNo636
9R:R:K239 R:R:Y171 67.82434.78YesYes675
10R:R:K239 R:R:L232 34.10169.87YesNo676
11R:R:L196 R:R:L211 67.58326.92YesYes369
12R:R:I474 R:R:L196 1007.14YesYes366
13R:R:I474 R:R:Y471 99.42527.25YesYes369
14R:R:K239 R:R:Y500 66.25567.17YesYes678
15R:R:L233 R:R:Y500 30.633912.89YesYes678
16R:R:L233 R:R:Y230 30.13539.38YesYes677
17R:R:K227 R:R:Y230 15.30229.55YesYes077
18R:R:K239 R:R:L262 35.6315.51YesNo677
19R:R:L262 R:R:W260 35.58476.83NoYes677
20R:R:A256 R:R:W260 68.05763.89NoYes077
21R:R:A256 S:S:L114 67.95723.15NoYes076
22S:S:L114 S:S:N110 35.219912.36YesYes2065
23R:R:W260 R:R:Y500 35.580514.47YesYes678
24R:R:K227 S:S:W149 14.735910.44YesYes077
25R:R:Y230 S:S:I121 14.755216.92YesNo076
26S:S:I121 S:S:W149 14.705222.31NoYes067
27R:R:V521 R:R:Y471 97.73265.05YesYes389
28R:R:N431 R:R:V521 98.085.91NoYes068
29R:R:N431 R:R:P432 97.81846.52NoNo064
30R:R:P432 R:R:V428 10.09937.07NoYes3145
31R:R:P432 R:R:W536 87.69299.46NoYes3143
32R:R:W536 R:R:Y552 87.57692.89YesYes034
33R:R:G551 R:R:Y552 87.5372.9NoYes074
34R:R:G551 R:R:I539 85.73553.53NoYes177
35R:R:H293 R:R:I539 85.41333.98YesYes157
36R:R:H293 R:R:R297 85.34913.39YesYes157
37R:R:R297 R:R:W306 84.117911YesYes179
38R:R:D576 R:R:W306 86.439125.68YesYes199
39R:R:D576 R:R:K308 86.45625.53YesYes097
40R:R:K308 R:R:Q577 86.360416.27YesNo075
41R:R:L579 R:R:Q577 86.32852.66NoNo035
42R:R:I581 R:R:L579 43.17125.71YesNo2123
43R:R:L579 R:R:L755 43.125215.22NoNo2134
44R:R:I581 R:R:P756 43.09323.39YesNo2125
45R:R:L755 R:R:P756 43.08624.93NoNo2145
46R:R:K743 R:R:P756 86.09445.02YesNo015
47R:R:K743 R:R:L758 85.839114.1YesYes015
48R:R:H760 R:R:L758 85.39245.14NoYes3345
49R:R:C761 R:R:H760 85.32812.95NoNo094
50R:R:C761 R:R:D831 85.24283.11NoNo097
51R:R:D831 R:R:F834 84.69685.97NoYes3577
52R:R:F834 R:R:V822 84.38982.62YesNo076
53R:R:S838 R:R:V822 84.30443.23NoNo076
54R:R:I841 R:R:S838 84.03454.64YesNo3677
55R:R:I841 R:R:V842 83.19313.07YesNo075
56R:R:L839 R:R:V842 83.02192.98NoNo035
57R:R:L601 R:R:L839 76.748311.07NoNo1733
58R:R:G602 R:R:L601 77.07865.13NoNo093
59R:R:G602 R:R:L605 76.9925.13NoYes094
60R:R:L605 R:R:L641 72.72749.69YesNo048
61R:R:A642 R:R:L641 72.55263.15NoNo038
62R:R:A642 R:R:L672 72.46513.15NoYes035
63R:R:L639 R:R:L672 72.027711.07YesYes065
64R:R:L639 R:R:S675 71.593YesNo069
65R:R:S675 R:R:V635 71.50236.46NoNo094
66R:R:N631 R:R:V635 23.33834.43NoNo084
67R:R:L632 R:R:N631 23.24695.49YesNo068
68R:R:V635 R:R:Y678 48.076715.14NoNo048
69R:R:L632 R:R:Y678 23.247122.27YesNo068
70R:R:L632 R:R:M681 46.1245.65YesNo069
71R:R:V714 R:R:Y678 24.7416.31NoNo078
72R:R:M681 R:R:V714 23.09367.61NoNo097
73R:R:L710 R:R:M681 68.93848.48YesNo089
74R:R:I685 R:R:L710 67.54632.85NoYes098
75R:R:H689 R:R:I685 66.989315.91NoNo089
76R:R:H689 R:R:W686 66.43236.35NoNo088
77R:R:T791 R:R:W686 66.153714.55NoNo098
78R:R:T690 R:R:T791 65.87526.28NoNo069
79R:R:E790 R:R:T690 65.59665.64NoNo086
80R:R:E790 S:S:F673 63.64628.16NoYes089
81R:R:F786 S:S:F673 62.252632.15YesYes099
82R:R:F786 S:S:F670 61.416310.72YesNo097
83S:S:N110 S:S:V138 32.69722.96YesNo2058
84S:S:C135 S:S:V138 65.086310.25YesNo068
85S:S:C108 S:S:C135 64.23973.64NoYes076
86S:S:C108 S:S:P63 39.57395.65NoYes1178
87S:S:M62 S:S:P63 39.07063.35YesYes1188
88S:S:L64 S:S:M62 23.674811.31YesYes058
89S:S:G74 S:S:L64 43.74885.13NoYes085
90S:S:G74 S:S:V77 43.30243.68NoYes085
91S:S:P351 S:S:V77 38.84663.53YesYes035
92S:S:P351 S:S:Y342 34.3569.74YesYes537
93S:S:Y342 S:S:Y359 26.2212.91YesYes579
94S:S:W363 S:S:Y359 17.63762.89YesYes089
95S:S:I330 S:S:W363 15.83017.05YesYes058
96S:S:F409 S:S:I330 13.1227.54NoYes025
97S:S:F408 S:S:F409 12.669718.22NoNo092
98S:S:F408 S:S:K367 12.21748.69NoNo097
99S:S:I141 S:S:L114 32.70724.28NoYes2056
100S:S:I141 S:S:V138 32.60317.68NoNo2058
101S:S:C108 S:S:V68 24.454410.25NoYes1172
102S:S:G71 S:S:V68 23.36693.68NoYes052
103S:S:G71 S:S:L64 23.15735.13NoYes055
104S:S:F131 S:S:M62 16.071318.66NoYes078
105S:S:F131 S:S:G60 15.19814.52NoNo077
106S:S:G60 S:S:I58 14.98193.53NoNo078
107S:S:I58 S:S:L56 14.33345.71NoNo086
108S:S:L128 S:S:L56 13.90115.54NoNo056
109S:S:L151 S:S:W149 27.782618.22NoYes077
110S:S:L151 S:S:Q153 27.67699.32NoYes079
111S:S:L128 S:S:M129 13.68519.9NoNo056
112S:S:L154 S:S:M129 13.03694.24YesNo076
113S:S:F172 S:S:Q153 26.85054.68YesYes989
114S:S:F172 S:S:Y169 26.400713.41YesNo987
115S:S:R174 S:S:Y169 26.180913.38YesNo997
116S:S:F156 S:S:L154 10.00677.31YesYes467
117S:S:A158 S:S:R174 25.74915.53NoYes089
118S:S:A158 S:S:T160 25.64073.36NoNo088
119S:S:P161 S:S:T160 25.20733.5NoNo068
120S:S:D214 S:S:P161 24.988111.27YesNo4056
121S:S:D214 S:S:N180 24.77414.04YesNo056
122S:S:N180 S:S:V218 24.665811.82NoYes063
123S:S:N183 S:S:V218 12.995114.78YesYes1893
124S:S:I186 S:S:N183 12.25758.5NoYes079
125S:S:I186 S:S:V182 12.15544.61NoYes075
126S:S:I426 S:S:V182 11.73273.07YesYes455
127S:S:I426 S:S:V317 12.7996.14YesNo056
128S:S:E222 S:S:V218 11.45454.28YesYes1853
129S:S:E222 S:S:I224 10.79998.2YesNo056
130S:S:I224 S:S:K196 10.57982.91NoNo065
131S:S:D466 S:S:K196 10.46898.3YesNo095
132S:S:F572 S:S:F670 61.137518.22NoNo097
133S:S:F572 S:S:L667 57.51166.09NoNo098
134S:S:K664 S:S:L667 56.95362.82YesNo098
135S:S:K664 S:S:V696 56.11643.04YesNo099
136S:S:F568 S:S:V696 52.207715.73NoNo089
137S:S:F568 S:S:Y564 51.928413.41NoYes089
138S:S:I534 S:S:Y564 30.09610.88YesYes4689
139S:S:I534 S:S:I729 15.7734.42YesNo086
140S:S:I729 S:S:T489 15.21053.04NoNo067
141S:S:L485 S:S:T489 13.23922.95YesNo057
142S:S:L485 S:S:Y482 12.39513.52YesYes055
143S:S:I477 S:S:Y482 11.55246.04YesYes075
144S:S:C722 S:S:I477 10.14523.27NoYes057
145S:S:I534 S:S:L560 14.085311.42YesNo087
146S:S:F537 S:S:L560 13.24127.31YesNo057
147S:S:D540 S:S:F537 12.11495.97NoYes4785
148S:S:C553 S:S:D540 11.83417.78NoNo098
149S:S:C553 S:S:T551 11.55273.38NoNo091
150S:S:T551 S:S:V544 10.98979.52NoNo015
151S:S:T548 S:S:V544 10.70827.93NoNo025
152S:S:V699 S:S:Y564 16.335411.36NoYes099
153S:S:T735 S:S:V699 14.64794.76NoNo089
154S:S:S695 S:S:T735 14.36666.4NoNo088
155S:S:L738 S:S:S695 14.08536.01NoNo078
156S:S:L738 S:S:P742 13.80393.28NoNo079
157S:S:P742 S:S:V741 13.52265.3NoNo096
158S:S:F740 S:S:V741 13.24122.62NoNo096
159S:S:F499 S:S:F740 12.115617.15NoNo079
160S:S:F499 S:S:K743 10.98972.48NoNo079
161R:R:K212 R:R:Y171 33.63258.36NoYes635
162R:R:L196 R:R:N200 33.79168.24YesNo369
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7CA5
Class C
SubFamily Aminoacid
Type GABAB
SubType GABAB1; GABAB2
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners -
PDB Resolution 7.6
Date 2020-11-11
D.O.I. doi.org/10.1016/j.jmb.2020.09.023
Net Summary
Imin 2.89
Number of Linked Nodes 1255
Number of Links 1477
Number of Hubs 223
Number of Links mediated by Hubs 796
Number of Communities 50
Number of Nodes involved in Communities 337
Number of Links involved in Communities 454
Path Summary
Number Of Nodes in MetaPath 163
Number Of Links MetaPath 162
Number of Shortest Paths 15232248
Length Of Smallest Path 3
Average Path Length 69.705
Length of Longest Path 115
Minimum Path Strength 1.265
Average Path Strength 7.88151
Maximum Path Strength 31.06
Minimum Path Correlation 0.71
Average Path Correlation 0.99955
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.32558
Average % Of Corr. Nodes 43.2907
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 50.3665
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• regulation of biological process   • signaling   • biological regulation   • cell-cell signaling   • neuron-glial cell signaling   • cellular process   • cell communication   • gamma-aminobutyric acid signaling pathway   • regulation of molecular function   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • negative regulation of molecular function   • negative regulation of catalytic activity   • negative regulation of adenylate cyclase activity   • trans-synaptic signaling   • synaptic signaling   • anterograde trans-synaptic signaling   • chemical synaptic transmission   • cellular response to stimulus   • regulation of cellular process   • response to stimulus   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • synaptic transmission, GABAergic   • cell periphery   • postsynapse   • cellular anatomical structure   • postsynaptic membrane   • synapse   • cell junction   • membrane   • plasma membrane   • plasma membrane region   • synaptic membrane   • protein-containing complex   • plasma membrane protein complex   • membrane protein complex   • receptor complex
Gene OntologyCellular Component• cell periphery   • postsynapse   • cellular anatomical structure   • postsynaptic membrane   • synapse   • cell junction   • membrane   • plasma membrane   • plasma membrane region   • synaptic membrane   • protein-containing complex   • plasma membrane protein complex   • membrane protein complex   • receptor complex   • GABA receptor complex   • G protein-coupled receptor dimeric complex   • plasma membrane signaling receptor complex   • G protein-coupled receptor complex   • G protein-coupled GABA receptor complex   • G protein-coupled receptor heterodimeric complex   • intracellular anatomical structure   • cytoplasm   • cell projection   • neuron projection   • plasma membrane bounded cell projection   • neurotransmitter receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • G protein-coupled neurotransmitter receptor activity   • G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential   • G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential   • postsynaptic neurotransmitter receptor activity   • neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential   • G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential   • protein binding   • binding   • extracellular matrix protein binding   • protein heterodimerization activity   • protein dimerization activity   • G protein-coupled GABA receptor activity   • GABA receptor activity   • developmental process   • multicellular organismal process   • cellular developmental process   • ossification   • cell differentiation   • cellular process   • osteoblast differentiation   • regulation of biological process   • signaling   • biological regulation   • cell-cell signaling   • neuron-glial cell signaling   • cell communication   • gamma-aminobutyric acid signaling pathway   • regulation of localization   • negative regulation of amino acid transport   • nitrogen compound transport   • negative regulation of amine transport   • transport   • negative regulation of biological process   • negative regulation of transport   • localization   • negative regulation of secretion   • gamma-aminobutyric acid transport   • negative regulation of gamma-aminobutyric acid secretion   • regulation of amino acid transport   • organic anion transport   • gamma-aminobutyric acid secretion   • carboxylic acid transport   • regulation of transport   • secretion   • regulation of gamma-aminobutyric acid secretion   • acid secretion   • establishment of localization   • regulation of secretion   • organic acid transport   • amino acid transport   • amine transport   • negative regulation of organic acid transport   • regulation of organic acid transport   • regulation of amine transport   • monoamine transport   • regulation of cellular process   • regulation of catecholamine secretion   • organic hydroxy compound transport   • dopamine transport   • secretion by cell   • regulation of secretion by cell   • catecholamine transport   • negative regulation of dopamine secretion   • signal release   • negative regulation of cellular process   • negative regulation of secretion by cell   • export from cell   • negative regulation of catecholamine secretion   • dopamine secretion   • catecholamine secretion   • regulation of dopamine secretion   • response to stimulus   • response to alcohol   • response to chemical   • response to oxygen-containing compound   • response to ethanol   • negative regulation of cell population proliferation   • cell population proliferation   • regulation of cell population proliferation   • epinephrine secretion   • epinephrine transport   • regulation of epinephrine secretion   • organic cation transport   • negative regulation of epinephrine secretion   • cellular response to stimulus   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • trans-synaptic signaling   • regulation of signaling   • negative regulation of signaling   • modulation of chemical synaptic transmission   • negative regulation of synaptic transmission   • negative regulation of cell communication   • chemical synaptic transmission   • synaptic signaling   • regulation of trans-synaptic signaling   • anterograde trans-synaptic signaling   • regulation of cell communication   • synaptic transmission, GABAergic   • response to nicotine   • positive regulation of cell communication   • regulation of hormone secretion   • regulation of peptide secretion   • positive regulation of biological process   • positive regulation of secretion by cell   • hormone secretion   • peptide secretion   • positive regulation of hormone secretion   • positive regulation of secretion   • amide transport   • regulation of biological quality   • regulation of peptide hormone secretion   • positive regulation of cellular process   • positive regulation of peptide secretion   • growth hormone secretion   • regulation of hormone levels   • regulation of growth hormone secretion   • regulation of peptide transport   • positive regulation of peptide hormone secretion   • peptide transport   • positive regulation of growth hormone secretion   • positive regulation of transport   • peptide hormone secretion   • hormone transport   • positive regulation of signaling   • regulation of glutamate secretion   • positive regulation of amine transport   • glutamate secretion   • positive regulation of glutamate secretion   • positive regulation of organic acid transport   • acidic amino acid transport   • positive regulation of amino acid transport   • dicarboxylic acid transport   • membrane-bounded organelle   • mitochondrial membrane   • mitochondrion   • intracellular membrane-bounded organelle   • intracellular organelle   • organelle envelope   • organelle   • mitochondrial envelope   • organelle membrane   • presynapse   • presynaptic membrane   • GABA-ergic synapse   • glutamatergic synapse   • organelle subcompartment   • endomembrane system   • endoplasmic reticulum subcompartment   • nuclear outer membrane-endoplasmic reticulum membrane network   • endoplasmic reticulum   • endoplasmic reticulum membrane   • somatodendritic compartment   • dendrite   • dendritic tree   • dendritic shaft   • neuron spine   • dendritic spine   • Schaffer collateral - CA1 synapse   • axon   • cell leading edge   • axolemma   • leading edge membrane   • neuron projection membrane   • main axon   • cell projection membrane   • cell body   • neuronal cell body   • extracellular region   • extracellular space   • transport vesicle   • intracellular vesicle   • cytoplasmic vesicle   • synaptic vesicle   • secretory vesicle   • vesicle   • exocytic vesicle
SCOP2Domain Identifier• Type 1 solute binding protein-like
SCOP2Family Identifier• Type 1 solute binding protein-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ9UBS5
Sequence
>7CA5_Chain_R
SERRAVYIG ALFPMSGGW PGGQACQPA VEMALEDVN SRRDILPDY 
ELKLIHHDS KCDPGQATK YLYELLYND PIKIILMPG CSSVSTLVA 
EAARMWNLI VLSYGSSSP ALSNRQRFP TFFRTHPSA TLHNPTRVK 
LFEKWGWKK IATIQQTTE VFTSTLDDL EERVKEAGI EITFRQSFF 
SDPAVPVKN LKRQDARII VGLFYETEA RKVFCEVYK ERLFGKKYV 
WFLIGWYAD NWFKIYDPS INCTVDEMT EAVEGHITT EIVMLNPAN 
TRSISNMTS QEFVEKLTK RLKRHPEET GGFQEAPLA YDAIWALAL 
ALNKTSRLE DFNYNNQTI TDQIYRAMN SSSFEGVSG HVVFDASGS 
RMAWTLIEQ LQGGSYKKI GYYDSTKDD LSWSKTDKW IGGSPPADQ 
TLVIKTFRF LSQKLFISV SVLSSLGIV LAVVCLSFN IYNSHVRYI 
QNSQPNLNN LTAVGCSLA LAAVFPLGL DGYHIGRNQ FPFVCQARL 
WLLGLGFSL GYGSMFTKI WWVHTVFEP WKLYATVGL LVGMDVLTL 
AIWQIVDPL HRTIETFAK EILPQLEHC SSRKMNTWL GIFYGYKGL 
LLLLGIFLA YETDHRAVG MAIYNVAVL CLITAPVTM ILSSQQDAA 
FAFASLAIV FSSYITLVV LFVPKMRRL ITR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtO75899
Sequence
>7CA5_Chain_S
SPPLSIMGL MPLTKEVAK GSIGRGVLP AVELAIEQI RNESLLRPY 
FLDLRLYDT ECDNAKGLK AFYDAIKYG PNHLMVFGG VCPSVTSII 
AESLQGWNL VQLSFAATT PVLADKKKY PYFFRTVPS DNAVNPAIL 
KLLKHYQWK RVGTLTQDV QRFSEVRND LTGVLYGED IEISDTESF 
SNDPCTSVK KLKGNDVRI ILGQFDQNM AAKVFCCAY EENMYGSKY 
QWIIPGWYE PSWWEQSRC LRKNLLAAM EGYIGVDFE PLSSKQIKT 
ISGKTPQQY EREYNNKRS GVGPSKFHG YAYDGIWVI AKTLQRAME 
TLHASIQDF NYTDHTLGR IILNAMNET NFFGVTGQV VFRNGERMG 
TIKFTQFQD SREVKVGEY NAVADTLEI INDTIRFQG SEPPKDKTI 
ILEQLRKIS LPLYSILSA LTILGMIMA SAFLFFNIK NRNQKLIKM 
SSPYMNNLI ILGGMLSYA SIFLFGLDG SFVSEKTFE TLCTVRTWI 
LTVGYTTAF GAMFAKTWR VHAIFKNIK DQKLLVIVG GMLLIDLCI 
LICWQAVDR TVEKYSMEP SIRPLLEHC ENTHMTIWL GIVYAYKGL 
LMLFGCFLA WETDSKYIG MSVYNVGIM CIIGAAVSF LNVQFCIVA 
LVIIFCSTI TLCLVFVPK LITLRTN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7CA3CAminoacidGABABGABAB1, GABAB2Homo sapiens-rac-BHFF-4.52020-11-11doi.org/10.1016/j.jmb.2020.09.023
7EB2CAminoacidGABABGABAB2; GABAB1Homo sapiensBaclofenrac-BHFFGi1/β1/γ23.52021-05-05doi.org/10.1038/s41586-021-03507-1
7EB2 (No Gprot) CAminoacidGABABGABAB2; GABAB1Homo sapiensBaclofenrac-BHFF3.52021-05-05doi.org/10.1038/s41586-021-03507-1
6WIVCAminoacidGABABGABAB1, GABAB2Homo sapiens-PubChem 52923113; PubChem 52924645-3.32020-07-01doi.org/10.1038/s41586-020-2452-0
6UO8CAminoacidGABABGABAB1, GABAB2Homo sapiensSKF97541GS39783-3.632020-06-10doi.org/10.1038/s41586-020-2408-4
7C7QCAminoacidGABABGABAB1, GABAB2Homo sapiensBaclofenBHFF-32020-07-01doi.org/10.1038/s41422-020-0350-5
6W2YCAminoacidGABABGABAB1; GABAB1Homo sapiensPubChem 5311042--3.22020-07-01doi.org/10.1038/s41586-020-2469-4
7CUMCAminoacidGABABGABAB1, GABAB2Homo sapiensCGP54626--3.522020-11-11doi.org/10.1016/j.jmb.2020.09.023
7C7SCAminoacidGABABGABAB1, GABAB2Homo sapiensCGP54626--2.92020-07-01doi.org/10.1038/s41422-020-0350-5
6UO9CAminoacidGABABGABAB1, GABAB2Homo sapiensSKF97541--4.82020-06-10doi.org/10.1038/s41586-020-2408-4
6UOACAminoacidGABABGABAB1, GABAB2Homo sapiens---6.32020-06-10doi.org/10.1038/s41586-020-2408-4
6VJMCAminoacidGABABGABAB1, GABAB2Homo sapiens---3.972020-06-10doi.org/10.1038/s41586-020-2408-4
6W2XCAminoacidGABABGABAB1, GABAB2Homo sapiensPubChem 5311042--3.62020-07-01doi.org/10.1038/s41586-020-2469-4




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