Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:R167 9.8625464
2R:R:Y171 20.49676235
3R:R:I172 9.375468
4R:R:F176 13.2545157
5R:R:G180 3.04754443
6R:R:W182 12.696516
7R:R:C188 2.7575405
8R:R:Q189 13.87754154
9R:R:V192 4.4725407
10R:R:L196 8.4725466
11R:R:N200 9.9975469
12R:R:L206 8.848569
13R:R:D208 6.86464
14R:R:Y209 9.38833668
15R:R:E210 11.465465
16R:R:L211 6.655669
17R:R:L213 7.9025406
18R:R:I214 12.60676233
19R:R:Y230 7.56407
20R:R:P237 9.7854236
21R:R:K239 18.6354237
22R:R:I240 8.175465
23R:R:I241 10.535467
24R:R:M243 8.75754157
25R:R:W260 15.815267
26R:R:Y267 7.55286717
27R:R:G268 5.06417
28R:R:L274 13.7125138
29R:R:F283 17.8965138
30R:R:R285 12.36336139
31R:R:T286 8.295417
32R:R:H287 5.41625817
33R:R:T291 7.6154476
34R:R:R297 6.124517
35R:R:K299 3.675616
36R:R:L300 8.91333616
37R:R:F301 10.71616
38R:R:K303 12.216514
39R:R:W304 10.4541017
40R:R:W306 20.0514719
41R:R:K308 8.55517
42R:R:I309 6.464518
43R:R:I312 7.905436
44R:R:Q313 11.64176277
45R:R:Q314 9.775438
46R:R:T316 3.645405
47R:R:F319 14.6985277
48R:R:D325 7.4025476
49R:R:R329 6.58143714
50R:R:V330 7.4725417
51R:R:I335 4.805417
52R:R:R340 12.782516
53R:R:F343 11.342537
54R:R:P350 6.9775437
55R:R:I361 13.988519
56R:R:L365 9.28254276
57R:R:F366 8.25333638
58R:R:E370 8.76435
59R:R:R372 5.73537
60R:R:F375 9.08667938
61R:R:E377 7.8537
62R:R:Y379 13.448537
63R:R:W390 17.6117639
64R:R:F391 13.8357717
65R:R:Y396 8.155635
66R:R:W400 8.89408
67R:R:F401 14.868537
68R:R:H422 13.874536
69R:R:I423 14.7775416
70R:R:T424 3.1875406
71R:R:T425 5.895406
72R:R:I427 11.024515
73R:R:M429 5.7525414
74R:R:N431 4.544506
75R:R:S439 4.68254468
76R:R:K449 7.184375
77R:R:G463 4.8025414
78R:R:E466 18.0225415
79R:R:L469 7.242516
80R:R:Y471 12.5425459
81R:R:I474 7.7575466
82R:R:W475 13.735328
83R:R:L481 13.28468
84R:R:K483 3.5404
85R:R:I505 5.232506
86R:R:F518 7.745329
87R:R:S530 7.0754135
88R:R:S532 4.318336137
89R:R:R533 8.274519
90R:R:W536 16.8665163
91R:R:T537 9.155416
92R:R:E540 7.354166
93R:R:Q541 14.43519
94R:R:Q543 10.694518
95R:R:Y547 10.6354165
96R:R:K548 11.225414
97R:R:K549 7.97254163
98R:R:I550 6.065417
99R:R:Y552 10.476164
100R:R:Y553 11.4338816
101R:R:D558 6.068514
102R:R:L560 13.8475417
103R:R:W562 8.7575815
104R:R:T565 9.6875413
105R:R:D566 16.0475415
106R:R:W568 16.0371719
107R:R:S572 2.745413
108R:R:P573 6.292515
109R:R:L579 5.87754143
110R:R:F584 8.5954384
111R:R:R585 7.82405
112R:R:L591 7.915336
113R:R:L601 4.158336203
114R:R:Y615 5.2454392
115R:R:T633 3.075407
116R:R:P646 3.77167676
117R:R:L649 8.465335
118R:R:H653 10.46754334
119R:R:I654 8.5385335
120R:R:F661 10.98401
121R:R:W668 5.445406
122R:R:L672 6.4275475
123R:R:S675 5.9685409
124R:R:Y678 14.46754408
125R:R:M681 5.55509
126R:R:I685 5.955409
127R:R:W686 13.0485108
128R:R:I727 11.63475
129R:R:W728 7.06571779
130R:R:V731 5.292574
131R:R:H735 11.6154514
132R:R:I738 5.71404
133R:R:K743 9.71754141
134R:R:C761 5.24254389
135R:R:M766 10.2575475
136R:R:W769 10.915478
137R:R:L770 5.476575
138R:R:F773 16.8675476
139R:R:I785 4.73754536
140R:R:F786 10.9725409
141R:R:T791 8.3654109
142R:R:F836 8.1865206
143R:R:I841 5.51754287
144R:R:F843 9.7325405
145R:R:Y846 10.194508
146R:R:M857 4.22406
147R:R:I861 11.914394
148R:R:T862 5.0554394
149S:S:L56 4.94346
150S:S:I58 10.354348
151S:S:P63 7.1665128
152S:S:T65 9.8154125
153S:S:V68 5.46254122
154S:S:G71 2.7375405
155S:S:P79 2.8525405
156S:S:E91 6.565445
157S:S:L94 10.53449
158S:S:R102 8.036676212
159S:S:Y104 7.535406
160S:S:F117 13.6554257
161S:S:Y118 8.665267
162S:S:G133 2.434226
163S:S:C135 4.89254126
164S:S:V138 5.874128
165S:S:Q147 10.07754246
166S:S:W149 12.6145257
167S:S:Q153 10.93754229
168S:S:F156 7.635446
169S:S:T160 4.24508
170S:S:F172 9.92754228
171S:S:F173 9.7825297
172S:S:R174 14.17754299
173S:S:T175 8.8875447
174S:S:V176 6.01333646
175S:S:D179 11.755457
176S:S:V182 7.8975455
177S:S:I186 3.778557
178S:S:L189 6.758556
179S:S:L190 12.674555
180S:S:W195 12.4014759
181S:S:L201 7.674117
182S:S:T202 6.534526
183S:S:D204 9.09426
184S:S:F208 7.69527
185S:S:R212 4.776525
186S:S:E230 12.47254118
187S:S:F232 12.4354117
188S:S:L243 7.4765118
189S:S:K244 8.1575428
190S:S:N246 7.434116
191S:S:V248 4.404527
192S:S:R249 15.00254119
193S:S:I250 5.4459
194S:S:Q254 11.235426
195S:S:F255 9.80833628
196S:S:D256 4.655427
197S:S:M259 7.068524
198S:S:F264 13.6717627
199S:S:E270 10.5675425
200S:S:M272 6.98427
201S:S:Y273 3.49525
202S:S:W279 8.625829
203S:S:I281 11.58426
204S:S:P282 6.3425405
205S:S:W284 10.314546
206S:S:Y285 16.188525
207S:S:W289 15.085629
208S:S:W290 18.545826
209S:S:L307 5.692527
210S:S:A310 5.34428
211S:S:M311 17.6675425
212S:S:Y314 10.3943725
213S:S:I315 6.7375455
214S:S:F319 7.11167644
215S:S:Q326 8.7075444
216S:S:T329 7.698547
217S:S:S331 9.865448
218S:S:K333 10.1883645
219S:S:P335 5.91404
220S:S:Y342 15.7117647
221S:S:R346 5.945644
222S:S:P351 6.176543
223S:S:F354 3.1725445
224S:S:Y357 8.314545
225S:S:Y359 16.576549
226S:S:D360 5.91649
227S:S:W363 11.4283648
228S:S:R371 10.94254354
229S:S:M373 10.0825444
230S:S:T375 5.635351
231S:S:F388 16.0254587
232S:S:I398 1.5404
233S:S:M403 8.11254295
234S:S:V411 6.206547
235S:S:V415 3.4175448
236S:S:R418 6.50254414
237S:S:R422 11.4683649
238S:S:T425 12.9453
239S:S:I426 14.3925455
240S:S:F431 10.25425
241S:S:V439 6.994556
242S:S:E441 16.8675454
243S:S:Y442 9.83756
244S:S:N443 9.9375454
245S:S:L449 4.07667657
246S:S:I451 5.8075454
247S:S:P464 7.9375459
248S:S:K467 6.2754115
249S:S:E472 13.31754171
250S:S:L474 5.86754173
251S:S:R475 6.866676184
252S:S:K476 3.6745174
253S:S:I477 7.0845187
254S:S:L479 7.5925181
255S:S:Y482 4.5565185
256S:S:T489 3.975407
257S:S:R507 16.254427
258S:S:Y518 17.0454425
259S:S:N520 6.764199
260S:S:I523 6.684198
261S:S:I524 5.75254607
262S:S:I534 8.044368
263S:S:F535 8.214596
264S:S:F537 10.515365
265S:S:E550 6.284593
266S:S:C553 8.865499
267S:S:W558 11.752586
268S:S:V562 4.05586
269S:S:G563 3.234589
270S:S:T566 3.9125487
271S:S:F568 14.31754618
272S:S:M571 8.7454198
273S:S:K574 6.1545199
274S:S:R577 5.22254439
275S:S:H579 13.5085108
276S:S:K593 8.0065436
277S:S:L605 4.325485
278S:S:W615 13.148599
279S:S:V618 11.9275494
280S:S:R623 9.024596
281S:S:E631 9.2865175
282S:S:L644 9.785174
283S:S:N650 7.295498
284S:S:H652 7.686594
285S:S:W656 5.93498
286S:S:F673 10.42254109
287S:S:L674 7.76254109
288S:S:V709 5.8025316
289S:S:V724 5.47754314
290S:S:F740 5.438509
291S:S:K743 4.0725409
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:L175 R:R:M243 96.63052.83NoYes067
2R:R:L175 R:R:S218 96.579310.51NoNo068
3R:R:P177 R:R:S218 96.52833.56NoNo078
4R:R:G180 R:R:P177 96.47732.03YesNo037
5R:R:C220 R:R:G180 96.33611.96NoYes083
6R:R:C220 R:R:P222 96.24973.77NoNo086
7R:R:G223 R:R:P222 48.10332.03NoNo076
8R:R:G223 R:R:T226 48.0465.46NoNo077
9R:R:T226 R:R:Y230 95.96322.5NoYes077
10R:R:P222 R:R:V249 48.10333.53NoNo068
11R:R:T226 R:R:V249 48.0464.76NoNo078
12R:R:Q189 R:R:V192 97.09142.87YesYes047
13R:R:V192 R:R:Y471 1003.79YesYes079
14R:R:D472 R:R:Y471 77.700819.54NoYes099
15R:R:D472 R:R:L469 77.79644.07NoYes096
16R:R:V521 R:R:Y471 26.72572.52NoYes089
17R:R:S437 R:R:V521 10.55994.85NoNo078
18R:R:Y230 S:S:F117 92.477316.5YesYes077
19S:S:F117 S:S:W149 92.07524.05YesYes2577
20R:R:L469 R:R:R533 76.11573.64YesYes169
21R:R:P288 R:R:R533 17.073510.09NoYes069
22R:R:P288 R:R:S532 16.99697.13NoYes067
23R:R:F280 R:R:N276 16.478312.08NoNo087
24R:R:N276 R:R:R279 16.295216.87NoNo076
25R:R:E255 R:R:R279 16.203818.61NoNo086
26R:R:E255 S:S:N110 16.11255.26NoNo085
27R:R:I427 R:R:R533 90.312520.04YesYes159
28R:R:I427 R:R:T537 93.3299.12YesYes156
29R:R:T537 R:R:Y553 30.77884.99YesYes166
30R:R:T425 R:R:T537 62.82644.71YesYes066
31R:R:R297 R:R:T425 61.63762.59YesYes076
32R:R:F301 R:R:R297 30.82516.41YesYes167
33R:R:L300 R:R:Y553 30.01695.86YesYes166
34R:R:F391 R:R:R297 30.67893.21YesYes177
35R:R:L300 R:R:W304 30.166914.81YesYes167
36R:R:N431 R:R:V521 31.47394.43YesNo068
37R:R:N431 R:R:P432 32.14254.89YesNo064
38R:R:P432 R:R:W536 32.277321.62NoYes1643
39R:R:W536 R:R:Y552 19.685619.29YesYes1634
40R:R:F301 R:R:W306 30.386840.09YesYes169
41R:R:F391 R:R:W306 30.91838.02YesYes179
42R:R:W304 R:R:W306 33.7987.5YesYes179
43R:R:K308 R:R:W306 95.06082.32YesYes179
44R:R:K308 R:R:Q577 95.22415.42YesNo075
45R:R:E540 R:R:T425 10.09125.64YesYes066
46R:R:E540 R:R:T424 16.64314.23YesYes066
47R:R:F366 R:R:F401 10.93293.22YesYes387
48R:R:F366 R:R:Q314 12.62129.37YesYes388
49R:R:F343 R:R:Q314 12.65852.34YesYes378
50R:R:L538 R:R:W536 13.165510.25NoYes1643
51R:R:K549 R:R:L538 13.184511.28YesNo1634
52R:R:E540 R:R:K549 13.00162.7YesYes1663
53R:R:K549 R:R:Y552 13.27289.55YesYes1634
54R:R:T424 R:R:Y396 12.7683.75YesYes065
55R:R:K549 R:R:Y547 13.4498.36YesYes1635
56R:R:L542 R:R:Y547 13.27025.86NoYes045
57R:R:E370 R:R:F366 10.23354.66YesYes358
58R:R:E370 R:R:T316 10.11724.23YesYes055
59R:R:L579 R:R:Q577 95.12635.32YesNo035
60R:R:L579 R:R:L755 94.298811.07YesNo1434
61R:R:L755 R:R:P756 94.24463.28NoNo1445
62R:R:K743 R:R:P756 94.03376.69YesNo1415
63R:R:K743 R:R:L758 93.851822.56YesNo015
64R:R:F584 R:R:L758 93.65526.09YesNo045
65R:R:F584 R:R:L587 91.38438.53YesNo047
66R:R:H653 R:R:L587 91.08682.57YesNo047
67R:R:H653 R:R:Y652 89.194831.58YesNo044
68R:R:G651 R:R:Y652 89.09494.35NoNo054
69R:R:F661 R:R:G651 88.9954.52YesNo015
70R:R:F661 R:R:W668 88.49462YesYes016
71R:R:P646 R:R:W668 88.09384.05YesYes066
72R:R:L672 R:R:P646 83.4186.57YesYes756
73R:R:L639 R:R:L672 83.34159.69NoYes065
74R:R:L639 R:R:S675 83.13763NoYes069
75R:R:S675 R:R:Y678 82.716715.26YesYes4098
76R:R:L632 R:R:Y678 82.21688.21NoYes068
77R:R:G679 R:R:L632 78.31671.71NoNo096
78R:R:G679 R:R:L629 70.76231.71NoNo096
79R:R:F682 R:R:L629 70.54998.53NoNo096
80R:R:F682 R:R:W686 69.97648.02NoYes1098
81R:R:T690 R:R:W686 34.8393.64NoYes1068
82R:R:T791 R:R:W686 34.83914.55YesYes1098
83R:R:E790 R:R:T690 34.72737.06NoNo1086
84R:R:E790 R:R:T791 34.73768.47NoYes1089
85R:R:E790 S:S:F673 69.23625.83NoYes1089
86R:R:F786 S:S:F673 41.303613.93YesYes099
87R:R:F786 S:S:F670 40.37152.14YesNo097
88S:S:L151 S:S:W149 93.43496.83NoYes077
89S:S:L151 S:S:Q153 93.298811.98NoYes079
90S:S:F172 S:S:Q153 92.868417.57YesYes2289
91S:S:F172 S:S:S155 92.75422.64YesNo2288
92S:S:G133 S:S:S155 92.47073.71YesNo2268
93S:S:A157 S:S:G133 67.01711.95NoYes076
94S:S:A157 S:S:F354 66.87852.77NoYes075
95S:S:F354 S:S:V176 15.1772.62YesYes456
96S:S:R422 S:S:V176 13.48619.15YesYes496
97S:S:D360 S:S:R422 23.95755.96YesYes499
98S:S:D360 S:S:V411 15.34545.84YesYes497
99S:S:F354 S:S:Y357 13.85025.16YesYes455
100S:S:R422 S:S:Y357 13.471116.46YesYes495
101S:S:F319 S:S:F354 37.71362.14YesYes445
102S:S:D318 S:S:F319 18.79035.97NoYes464
103S:S:D318 S:S:K427 19.01812.77NoNo065
104S:S:K427 S:S:P321 18.869110.04NoNo054
105S:S:A158 S:S:G133 25.33651.95NoYes086
106S:S:A158 S:S:T160 25.19165.03NoYes088
107S:S:R207 S:S:T160 19.21183.88NoYes058
108S:S:F319 S:S:W284 19.10738.02YesYes446
109S:S:R207 S:S:W284 18.89175NoYes456
110S:S:E320 S:S:P321 17.61663.14NoNo044
111S:S:E320 S:S:T425 16.699412.7NoYes543
112S:S:T425 S:S:Y442 16.09947.49YesYes536
113S:S:P282 S:S:W284 37.89215.4YesYes056
114S:S:I281 S:S:P282 32.50658.47YesYes065
115S:S:I281 S:S:Y314 25.293518.13YesYes265
116S:S:W279 S:S:Y314 13.85767.72YesYes295
117S:S:W279 S:S:Y277 11.182430.87YesNo298
118S:S:V248 S:S:Y277 10.57872.52YesNo278
119S:S:F572 S:S:F670 40.138320.36NoNo097
120S:S:F572 S:S:L667 39.90529.74NoNo098
121S:S:G569 S:S:L667 37.80521.71NoNo098
122S:S:G569 S:S:M604 37.57173.49NoNo096
123S:S:M604 S:S:Y663 37.101914.37NoNo865
124S:S:D608 S:S:Y663 36.8712.3NoNo895
125S:S:D608 S:S:V562 34.74644.38NoYes896
126S:S:G563 S:S:V562 33.11153.68YesYes896
127S:S:G563 S:S:S533 31.48831.86YesNo098
128S:S:L560 S:S:S533 31.25396.01NoNo078
129S:S:I534 S:S:L560 30.07238.56YesNo3687
130S:S:I534 S:S:S732 29.61186.19YesNo088
131S:S:C731 S:S:S732 29.37711.72NoNo078
132S:S:C731 S:S:I728 28.43153.27NoNo3178
133S:S:I728 S:S:V724 28.20293.07NoYes3184
134S:S:V709 S:S:V724 25.599714.43YesYes3164
135S:S:F721 S:S:V709 24.67527.87NoYes076
136S:S:C722 S:S:F721 24.43976.98NoNo057
137S:S:C722 S:S:I477 24.20424.91NoYes057
138S:S:I477 S:S:R475 17.34943.76YesYes1874
139S:S:E646 S:S:R475 13.08084.65NoYes064
140S:S:F673 S:S:L674 22.51336.09YesYes1099
141S:S:L674 S:S:T575 22.081513.27YesNo099
142S:S:K574 S:S:T575 21.84573YesNo099
143S:S:I692 S:S:V739 19.01177.68NoNo088
144S:S:K743 S:S:V739 18.5374.55YesNo098
145S:S:I524 S:S:K743 10.93567.27YesYes079
146R:R:M243 R:R:Q189 95.795719.03YesYes1574
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7CA5
Class C
SubFamily Aminoacid
Type GABAB
SubType GABAB1; GABAB2
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners -
PDB Resolution 7.6
Date 2020-11-11
D.O.I. 10.1016/j.jmb.2020.09.023
Net Summary
Imin 1.95
Number of Linked Nodes 1249
Number of Links 1631
Number of Hubs 291
Number of Links mediated by Hubs 1016
Number of Communities 62
Number of Nodes involved in Communities 557
Number of Links involved in Communities 839
Path Summary
Number Of Nodes in MetaPath 147
Number Of Links MetaPath 146
Number of Shortest Paths 8538008
Length Of Smallest Path 3
Average Path Length 54.6848
Length of Longest Path 108
Minimum Path Strength 1.21
Average Path Strength 7.86643
Maximum Path Strength 39.39
Minimum Path Correlation 0.71
Average Path Correlation 0.99906
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.5
Average % Of Corr. Nodes 53.3115
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 58.6681
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ9UBS5
Sequence
>7CA5_Chain_R
SERRAVYIG ALFPMSGGW PGGQACQPA VEMALEDVN SRRDILPDY 
ELKLIHHDS KCDPGQATK YLYELLYND PIKIILMPG CSSVSTLVA 
EAARMWNLI VLSYGSSSP ALSNRQRFP TFFRTHPSA TLHNPTRVK 
LFEKWGWKK IATIQQTTE VFTSTLDDL EERVKEAGI EITFRQSFF 
SDPAVPVKN LKRQDARII VGLFYETEA RKVFCEVYK ERLFGKKYV 
WFLIGWYAD NWFKIYDPS INCTVDEMT EAVEGHITT EIVMLNPAN 
TRSISNMTS QEFVEKLTK RLKRHPEET GGFQEAPLA YDAIWALAL 
ALNKTSRLE DFNYNNQTI TDQIYRAMN SSSFEGVSG HVVFDASGS 
RMAWTLIEQ LQGGSYKKI GYYDSTKDD LSWSKTDKW IGGSPPADQ 
TLVIKTFRF LSQKLFISV SVLSSLGIV LAVVCLSFN IYNSHVRYI 
QNSQPNLNN LTAVGCSLA LAAVFPLGL DGYHIGRNQ FPFVCQARL 
WLLGLGFSL GYGSMFTKI WWVHTVFEP WKLYATVGL LVGMDVLTL 
AIWQIVDPL HRTIETFAK EILPQLEHC SSRKMNTWL GIFYGYKGL 
LLLLGIFLA YETDHRAVG MAIYNVAVL CLITAPVTM ILSSQQDAA 
FAFASLAIV FSSYITLVV LFVPKMRRL ITR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtO75899
Sequence
>7CA5_Chain_S
SPPLSIMGL MPLTKEVAK GSIGRGVLP AVELAIEQI RNESLLRPY 
FLDLRLYDT ECDNAKGLK AFYDAIKYG PNHLMVFGG VCPSVTSII 
AESLQGWNL VQLSFAATT PVLADKKKY PYFFRTVPS DNAVNPAIL 
KLLKHYQWK RVGTLTQDV QRFSEVRND LTGVLYGED IEISDTESF 
SNDPCTSVK KLKGNDVRI ILGQFDQNM AAKVFCCAY EENMYGSKY 
QWIIPGWYE PSWWEQSRC LRKNLLAAM EGYIGVDFE PLSSKQIKT 
ISGKTPQQY EREYNNKRS GVGPSKFHG YAYDGIWVI AKTLQRAME 
TLHASIQDF NYTDHTLGR IILNAMNET NFFGVTGQV VFRNGERMG 
TIKFTQFQD SREVKVGEY NAVADTLEI INDTIRFQG SEPPKDKTI 
ILEQLRKIS LPLYSILSA LTILGMIMA SAFLFFNIK NRNQKLIKM 
SSPYMNNLI ILGGMLSYA SIFLFGLDG SFVSEKTFE TLCTVRTWI 
LTVGYTTAF GAMFAKTWR VHAIFKNIK DQKLLVIVG GMLLIDLCI 
LICWQAVDR TVEKYSMEP SIRPLLEHC ENTHMTIWL GIVYAYKGL 
LMLFGCFLA WETDSKYIG MSVYNVGIM CIIGAAVSF LNVQFCIVA 
LVIIFCSTI TLCLVFVPK LITLRTN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6W2YCAminoacidGABABGABAB1; GABAB1Homo sapiensPubChem 5311042PubChem 23727970-3.22020-07-0110.1038/s41586-020-2469-4
6UO8CAminoacidGABABGABAB1, GABAB2Homo sapiensSKF97541GS39783-3.632020-06-1010.1038/s41586-020-2408-4
6UO9CAminoacidGABABGABAB1, GABAB2Homo sapiensSKF97541--4.82020-06-1010.1038/s41586-020-2408-4
6UOACAminoacidGABABGABAB1, GABAB2Homo sapiens---6.32020-06-1010.1038/s41586-020-2408-4
6VJMCAminoacidGABABGABAB1, GABAB2Homo sapiens---3.972020-06-1010.1038/s41586-020-2408-4
6W2XCAminoacidGABABGABAB1, GABAB2Homo sapiensPubChem 5311042PubChem 23727970-3.62020-07-0110.1038/s41586-020-2469-4
6WIVCAminoacidGABABGABAB1, GABAB2Homo sapiens-PubChem 52923113; PubChem 52924645-3.32020-07-0110.1038/s41586-020-2452-0
7C7QCAminoacidGABABGABAB1, GABAB2Homo sapiensBaclofenPubChem 7023848-32020-07-0110.1038/s41422-020-0350-5
7C7SCAminoacidGABABGABAB1, GABAB2Homo sapiensCGP54626--2.92020-07-0110.1038/s41422-020-0350-5
7CA3CAminoacidGABABGABAB1, GABAB2Homo sapiens-rac-BHFF-4.52020-11-1110.1016/j.jmb.2020.09.023
7CUMCAminoacidGABABGABAB1, GABAB2Homo sapiensCGP54626Phospholipid-3.522020-11-1110.1016/j.jmb.2020.09.023
7EB2CAminoacidGABABGABAB1, GABAB2Homo sapiensBaclofenrac-BHFFGi1/&β;1/&γ;23.52021-05-0510.1038/s41586-021-03507-1




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