Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1H:H:?5 21.4725400
2H:H:?9 18.216500
3R:R:Y171 8.1125405
4R:R:G173 2.184297
5R:R:F176 4.42627
6R:R:W182 5.5025426
7R:R:Q189 5.374524
8R:R:P190 3.115425
9R:R:M194 3.48447
10R:R:L196 2.8425406
11R:R:L206 4.265409
12R:R:Y209 6.665358
13R:R:I214 3.81754293
14R:R:Q224 5.5654365
15R:R:Y234 5.262565
16R:R:K239 4.50754297
17R:R:P244 3.9675408
18R:R:E255 4.4425438
19R:R:W260 6.266567
20R:R:S266 3.57438
21R:R:S269 4.01438
22R:R:L274 5.375638
23R:R:F280 6.88538
24R:R:F283 4.76538
25R:R:F284 5.7456126
26R:R:R285 4.405439
27R:R:S289 3.2375438
28R:R:N294 4.8925499
29R:R:W304 13.6175477
30R:R:W306 6.722579
31R:R:T311 3.31754397
32R:R:Q314 5.65254168
33R:R:T316 6.7054165
34R:R:F319 7.3685167
35R:R:R329 4.0575494
36R:R:F339 10.0165386
37R:R:F343 2.9175407
38R:R:R360 5.5075409
39R:R:I361 3.76579
40R:R:R372 3.7425427
41R:R:F375 6.2825428
42R:R:V378 5.07428
43R:R:Y388 6.0325408
44R:R:F391 3.67677
45R:R:Y396 11.29425
46R:R:W400 7.53528
47R:R:I408 4.2754173
48R:R:C410 5.3954179
49R:R:E414 9.234177
50R:R:M415 6.2354176
51R:R:E420 5.7675456
52R:R:T424 4.03456
53R:R:L430 4.26443
54R:R:F446 8.0525447
55R:R:R456 5.185404
56R:R:G463 2.575424
57R:R:F464 6.015407
58R:R:E466 5.9825425
59R:R:P468 3.2775445
60R:R:Y471 7.085649
61R:R:D472 4.625409
62R:R:W475 7.5575448
63R:R:F498 3.1725468
64R:R:Y500 6.93468
65R:R:T504 3.27254414
66R:R:M513 3.994126
67R:R:F518 5.9125409
68R:R:G520 2.86754409
69R:R:D528 9.44126
70R:R:L538 7.295454
71R:R:E540 6.25456
72R:R:Q541 6.4409
73R:R:L542 6.84454
74R:R:G545 1.83454
75R:R:I550 4.204597
76R:R:Y552 5.3375454
77R:R:Y553 6.1965216
78R:R:D554 5.965435
79R:R:W562 6.9125405
80R:R:W568 7.232579
81R:R:P573 4.344575
82R:R:P574 2.86479
83R:R:D576 3.9409
84R:R:F592 4.3125185
85R:R:L641 3.5875408
86R:R:L649 3.442505
87R:R:W668 9.772506
88R:R:L672 3.3625405
89R:R:F682 3.7045109
90R:R:I685 3.5825109
91R:R:W686 4.42254108
92R:R:H689 5.4975408
93R:R:Y711 5.7085225
94R:R:V714 4.7225407
95R:R:V718 3.678507
96R:R:D732 4.736508
97R:R:L734 7.015476
98R:R:P756 5.554135
99R:R:E759 3.5654447
100R:R:L770 3.65405
101R:R:Y774 5.33406
102R:R:I785 3.68254506
103R:R:F786 6.8625509
104R:R:L787 3.9685109
105R:R:T791 6.4765109
106R:R:F834 7.39754187
107R:R:I841 3.254457
108R:R:F853 5.114469
109S:S:M59 5.8665147
110S:S:L61 3.124146
111S:S:M62 3.0285518
112S:S:P63 3.8954518
113S:S:P79 2.544305
114S:S:Y97 8.12667608
115S:S:L103 4.25401
116S:S:Y104 5.21254146
117S:S:K115 8.13466
118S:S:F117 4.5925407
119S:S:Y118 3.56407
120S:S:P125 5.25254147
121S:S:H127 6.7765148
122S:S:V138 3.514258
123S:S:P161 8.17254116
124S:S:K168 7.74265
125S:S:Y171 5.453336156
126S:S:F172 6.71254118
127S:S:F173 6.8325157
128S:S:R174 5.9954119
129S:S:S178 6.31254118
130S:S:N183 5.0625409
131S:S:W195 5.728519
132S:S:R197 4.2375416
133S:S:V198 3.115418
134S:S:G199 2.124518
135S:S:Q203 5.94833617
136S:S:F208 7.775417
137S:S:R212 6.614515
138S:S:D228 7.46415
139S:S:E230 5.74418
140S:S:F232 6.718517
141S:S:P236 7.745415
142S:S:V240 2.325406
143S:S:L243 3.938518
144S:S:R249 5.386519
145S:S:I250 3.562519
146S:S:L252 4.0525416
147S:S:Q254 5.4875406
148S:S:F255 3.36618
149S:S:M259 3.598514
150S:S:Y268 10.0354316
151S:S:Y273 9.39254315
152S:S:I281 3.57416
153S:S:Y285 8.96415
154S:S:W289 8.596519
155S:S:W290 5.25516
156S:S:M311 2.265405
157S:S:Y314 7.63415
158S:S:E320 8.22754534
159S:S:Q337 9.94325
160S:S:Y338 5.66407
161S:S:R340 6.44754322
162S:S:Y342 15.844247
163S:S:K345 5.65254303
164S:S:R346 9.70254244
165S:S:S352 3.974246
166S:S:H355 12.99754247
167S:S:Y357 3.03254525
168S:S:Y359 6.286509
169S:S:D360 3.50754529
170S:S:W363 7.098508
171S:S:R381 7.455404
172S:S:F388 3.3654277
173S:S:D392 6.6554276
174S:S:L395 4.0754276
175S:S:L400 5.00254153
176S:S:F409 4.478502
177S:S:R422 7.4625409
178S:S:K427 8.77254535
179S:S:F428 3.58618
180S:S:F431 10.315415
181S:S:K438 5.7354533
182S:S:G440 2.0875407
183S:S:E441 6.0025404
184S:S:Y442 4.59714716
185S:S:L449 4.5125417
186S:S:P463 3.675405
187S:S:D466 5.14419
188S:S:I477 4.2625407
189S:S:Y482 7.07754335
190S:S:G492 3.2625408
191S:S:F499 8.084207
192S:S:L500 3.38254568
193S:S:G526 1.97409
194S:S:L529 4.15754575
195S:S:Y531 5.0475408
196S:S:F535 8.28754336
197S:S:F549 13.765404
198S:S:W558 4.13406
199S:S:I559 3.6475404
200S:S:G563 3.644579
201S:S:Y564 6.3675409
202S:S:H579 9.254238
203S:S:W615 6.996589
204S:S:D619 5.254589
205S:S:L621 6.15486
206S:S:R642 8.4954284
207S:S:L644 5.3365284
208S:S:M653 7.4125485
209S:S:W656 8.365488
210S:S:L657 3.1775485
211S:S:Y661 4.3275486
212S:S:M668 2.0375408
213S:S:L674 7.65254239
214S:S:E677 8.48754239
215S:S:Y691 5.978506
216S:S:I692 2.554508
217S:S:M702 4.471676597
218S:S:F711 4.34485
219S:S:N718 4.2575407
220S:S:Q720 8.88754605
221S:S:F721 6.8525407
222S:S:C731 4.164597
223S:S:F740 11.84754209
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:F176 R:R:Q189 61.34237.03YesYes274
2R:R:M178 R:R:Q189 70.30024.08NoYes054
3R:R:D217 R:R:M178 70.39919.7NoNo085
4R:R:D217 R:R:K219 70.497911.06NoNo085
5R:R:K219 R:R:Q224 70.8932.71NoYes055
6S:S:F117 S:S:M59 85.42762.49YesYes077
7S:S:F117 S:S:I142 81.56093.77YesNo077
8S:S:I142 S:S:S145 81.46394.64NoNo077
9R:R:T226 S:S:S145 81.36694.8NoNo077
10R:R:G223 R:R:T226 81.26981.82NoNo077
11R:R:G223 R:R:Q224 72.59051.64NoYes3675
12R:R:F176 R:R:G185 58.05474.52YesNo277
13R:R:G184 R:R:G185 57.95852.11NoNo257
14R:R:G184 R:R:W182 56.5987.04NoYes256
15R:R:W182 R:R:W395 56.03995.62YesNo265
16R:R:I393 R:R:W395 12.43094.7NoNo255
17R:R:I393 R:R:L365 12.33542.85NoNo056
18R:R:F319 R:R:L365 12.230512.18YesNo076
19R:R:F319 R:R:Q314 11.70444.68YesYes1678
20R:R:Q314 R:R:T315 11.39144.25YesNo1686
21R:R:S342 R:R:T315 11.28933.2NoNo076
22R:R:Q313 R:R:S342 11.18472.89NoNo077
23R:R:L323 R:R:Q313 10.97657.99NoNo067
24R:R:L323 R:R:T311 10.56072.95NoYes067
25R:R:T311 R:R:V363 10.14733.17YesNo077
26R:R:F391 R:R:V363 10.0442.62YesNo077
27R:R:F391 R:R:I423 29.22175.02YesNo076
28R:R:I423 R:R:Q541 28.90495.49NoYes069
29R:R:W395 R:R:Y396 43.50816.4NoYes255
30R:R:E368 R:R:Y396 43.314115.71NoYes275
31R:R:E368 R:R:W400 41.20714.17NoYes278
32R:R:F375 R:R:W400 39.79162YesYes288
33R:R:F375 R:R:V378 37.57955.24YesYes288
34R:R:L383 R:R:V378 36.84444.47NoYes078
35R:R:L383 R:R:Y388 36.64464.69NoYes078
36R:R:D358 R:R:Y388 18.01194.6NoYes098
37R:R:D358 R:R:R360 17.90754.76NoYes099
38R:R:I361 R:R:R360 28.82982.51YesYes099
39R:R:F391 R:R:I361 20.15452.51YesYes779
40R:R:K387 R:R:Y388 18.117911.94NoYes068
41R:R:K387 R:R:R360 17.90912.38NoYes069
42R:R:G421 R:R:Q541 21.62323.29NoYes079
43R:R:E420 R:R:G421 21.30573.27YesNo067
44R:R:E420 R:R:L542 20.034813.25YesYes564
45R:R:E540 R:R:T424 17.81142.82YesYes566
46R:R:W536 R:R:Y552 11.45086.75NoYes034
47R:R:D554 R:R:W536 10.17856.7YesNo053
48S:S:L61 S:S:M59 97.97322.83YesYes1467
49S:S:G60 S:S:L61 73.90381.71NoYes076
50S:S:G60 S:S:L103 74.0411.71NoYes071
51S:S:L103 S:S:M62 24.81032.83YesYes018
52S:S:G74 S:S:M62 49.72751.75NoYes088
53S:S:G74 S:S:V77 49.73721.84NoNo085
54S:S:S352 S:S:V77 49.74693.23YesNo065
55S:S:H355 S:S:S352 74.5986.97YesYes2476
56S:S:H355 S:S:Y338 74.779111.98YesYes077
57S:S:V411 S:S:Y338 1003.79NoYes077
58S:S:P335 S:S:V411 99.99333.53NoNo047
59S:S:P335 S:S:T334 99.98661.75NoNo048
60S:S:Q326 S:S:T334 99.825.67NoNo048
61S:S:Q326 S:S:Q336 99.81323.84NoNo043
62S:S:E339 S:S:Q336 99.95772.55NoNo023
63S:S:E339 S:S:L322 99.95082.65NoNo024
64S:S:L322 S:S:P321 99.9441.64NoNo044
65S:S:E320 S:S:P321 99.937111YesNo044
66S:S:E320 S:S:K427 99.602212.15YesYes5345
67S:S:G440 S:S:K427 99.62811.74YesYes075
68S:S:F428 S:S:G440 99.71383.01YesYes087
69S:S:F428 S:S:L449 99.55584.87YesYes187
70S:S:I451 S:S:L449 99.70092.85NoYes147
71S:S:I451 S:S:Y193 99.66112.42NoNo148
72S:S:W195 S:S:Y193 99.67869.65YesNo198
73S:S:I250 S:S:W195 51.35492.35YesYes199
74S:S:I250 S:S:R249 49.15172.51YesYes199
75S:S:K465 S:S:R249 96.43214.95NoYes149
76S:S:I469 S:S:K465 96.51955.82NoNo024
77S:S:I469 S:S:I470 96.30191.47NoNo023
78S:S:I470 S:S:S640 96.24754.64NoNo033
79S:S:E631 S:S:S640 96.138611.5NoNo053
80S:S:E631 S:S:P632 96.08411.57NoNo052
81S:S:M630 S:S:P632 95.75691.68NoNo012
82S:S:M630 S:S:Y628 95.64772.39NoNo014
83S:S:L645 S:S:Y628 95.538511.72NoNo054
84S:S:L645 S:S:P717 95.417511.49NoNo5555
85S:S:P717 S:S:Q716 95.37451.58NoNo055
86S:S:N718 S:S:Q716 95.2653.96YesNo075
87S:S:I477 S:S:N718 94.99125.66YesYes077
88S:S:F721 S:S:I477 94.66213.77YesYes077
89S:S:F721 S:S:Y482 91.115110.32YesYes075
90S:S:F535 S:S:Y482 45.53512.06YesYes3365
91S:S:F535 S:S:L536 45.412113.4YesNo3366
92S:S:L536 S:S:R556 90.690313.36NoNo067
93S:S:I559 S:S:R556 88.1072.51YesNo047
94S:S:I559 S:S:W558 79.21164.7YesYes046
95S:S:L612 S:S:W558 79.10665.69NoYes076
96S:S:L609 S:S:L612 78.71584.15NoNo047
97S:S:D608 S:S:L609 78.58542.71NoNo094
98S:S:D608 S:S:T565 78.19445.78NoNo098
99S:S:L605 S:S:T565 78.0642.95NoNo058
100S:S:L605 S:S:V601 77.52842.98NoNo5857
101S:S:G569 S:S:V601 77.41191.84NoNo097
102S:S:F572 S:S:G569 77.28141.51NoNo099
103S:S:F572 S:S:F670 77.15097.5NoNo097
104R:R:F786 S:S:F670 77.02046.43YesNo097
105R:R:F786 S:S:F673 73.621610.72YesNo099
106R:R:L787 S:S:F673 73.22432.44YesNo099
107R:R:I685 R:R:L787 67.44432.85YesYes1099
108R:R:A788 R:R:I685 66.82691.62NoYes099
109R:R:A788 R:R:G806 66.69511.95NoNo097
110R:R:G806 R:R:I809 66.29153.53NoNo4878
111R:R:I809 R:R:M681 66.16758.75NoNo089
112R:R:K684 R:R:M681 66.03562.88NoNo099
113R:R:K684 R:R:L629 64.71534.23NoNo096
114R:R:L629 R:R:Y711 64.44723.52NoYes2265
115R:R:V714 R:R:Y711 63.92242.52YesYes075
116R:R:G679 R:R:V714 31.8291.84NoYes097
117R:R:G679 R:R:V718 31.69481.84NoYes097
118R:R:S675 R:R:V718 32.92893.23NoYes097
119R:R:D721 R:R:S675 19.61817.36NoNo099
120R:R:D721 R:R:F773 19.07384.78NoNo096
121R:R:F773 R:R:T724 18.801811.67NoNo066
122R:R:T724 R:R:W769 18.25723.64NoNo1968
123R:R:W728 R:R:W769 17.98640.3NoNo1998
124R:R:S763 R:R:W728 16.0798.65NoNo1989
125R:R:D732 R:R:S763 15.81182.94YesNo088
126R:R:D732 R:R:P733 14.45251.61YesNo089
127R:R:L734 R:R:P733 12.81813.28YesNo069
128S:S:L61 S:S:T106 24.67394.42YesNo068
129S:S:P63 S:S:T106 24.69175.25YesNo088
130S:S:M62 S:S:P63 24.80875.03YesYes5188
131S:S:L103 S:S:L78 49.64912.77YesNo014
132S:S:L78 S:S:P79 49.77761.64NoYes045
133S:S:G76 S:S:P79 24.87842.03NoYes055
134S:S:G76 S:S:S352 24.89861.86NoYes056
135S:S:K345 S:S:P79 24.91973.35YesYes3035
136S:S:K345 S:S:L83 24.99698.46YesNo037
137S:S:L83 S:S:Y359 25.01422.34NoYes079
138S:S:Y338 S:S:Y359 25.24073.97YesYes079
139S:S:D466 S:S:W195 48.2027.82YesYes199
140S:S:D466 S:S:R249 47.99614.76YesYes199
141S:S:L539 S:S:Y482 45.46817.03NoYes3355
142S:S:L536 S:S:L539 45.40664.15NoNo3365
143R:R:G715 R:R:V714 31.8291.84NoYes017
144R:R:G715 R:R:V718 31.69483.68NoYes017
145R:R:L672 R:R:S675 13.084.5YesNo059
146R:R:G673 R:R:L672 25.58731.71NoYes095
147R:R:G673 R:R:L639 25.04315.13NoNo096
148R:R:L639 R:R:L669 36.740113.84NoNo065
149R:R:A643 R:R:L669 35.92391.58NoNo085
150R:R:A643 R:R:L670 35.10811.58NoNo088
151R:R:F674 R:R:L670 33.476610.96NoNo098
152R:R:F674 R:R:I841 31.84513.77NoYes097
153R:R:I841 R:R:V644 22.87044.61YesNo4578
154R:R:S599 R:R:V644 22.05613.23NoNo078
155R:R:L676 R:R:V718 29.66395.96NoYes077
156R:R:L672 R:R:L676 13.06832.77YesNo057
157R:R:G677 R:R:L676 16.34051.71NoNo077
158R:R:G636 R:R:G677 16.06782.11NoNo097
159R:R:G636 R:R:L639 12.52871.71NoNo096
160R:R:S596 R:R:S599 13.08131.63NoNo037
161R:R:F592 R:R:S596 10.63216.61YesNo1853
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 6UOA
Class C
SubFamily Aminoacid
Type GABAB
SubType GABAB1; GABAB2
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners -
PDB Resolution 6.3
Date 2020-06-10
D.O.I. 10.1038/s41586-020-2408-4
Net Summary
Imin 1.64
Number of Linked Nodes 1243
Number of Links 1467
Number of Hubs 223
Number of Links mediated by Hubs 792
Number of Communities 60
Number of Nodes involved in Communities 367
Number of Links involved in Communities 475
Path Summary
Number Of Nodes in MetaPath 162
Number Of Links MetaPath 161
Number of Shortest Paths 13532333
Length Of Smallest Path 3
Average Path Length 89.6358
Length of Longest Path 136
Minimum Path Strength 1.27
Average Path Strength 4.54931
Maximum Path Strength 41.98
Minimum Path Correlation 0.74
Average Path Correlation 0.999482
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.14943
Average % Of Corr. Nodes 40.5075
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 35.9487
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• regulation of biological process   • signaling   • biological regulation   • cell-cell signaling   • neuron-glial cell signaling   • cellular process   • cell communication   • cellular response to stimulus   • regulation of cellular process   • response to stimulus   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • trans-synaptic signaling   • synaptic transmission, GABAergic   • chemical synaptic transmission   • synaptic signaling   • anterograde trans-synaptic signaling   • gamma-aminobutyric acid signaling pathway   • cell periphery   • postsynapse   • cellular anatomical structure   • postsynaptic membrane   • synapse   • cell junction   • membrane   • plasma membrane   • plasma membrane region   • synaptic membrane   • protein-containing complex   • plasma membrane protein complex   • membrane protein complex   • receptor complex
Gene OntologyCellular Component• cell periphery   • postsynapse   • cellular anatomical structure   • postsynaptic membrane   • synapse   • cell junction   • membrane   • plasma membrane   • plasma membrane region   • synaptic membrane   • protein-containing complex   • plasma membrane protein complex   • membrane protein complex   • receptor complex   • GABA receptor complex   • G protein-coupled receptor dimeric complex   • plasma membrane signaling receptor complex   • G protein-coupled receptor complex   • G protein-coupled GABA receptor complex   • extracellular region   • Schaffer collateral - CA1 synapse   • G protein-coupled receptor heterodimeric complex   • presynapse   • presynaptic membrane   • somatodendritic compartment   • cell projection   • dendrite   • dendritic tree   • neuron projection   • plasma membrane bounded cell projection   • intracellular anatomical structure   • cytoplasm   • GABA-ergic synapse   • protein heterodimerization activity   • protein binding   • binding   • protein dimerization activity   • G protein-coupled GABA receptor activity   • GABA receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • regulation of biological process   • signaling   • biological regulation   • cell-cell signaling   • neuron-glial cell signaling   • cellular process   • cell communication   • gamma-aminobutyric acid signaling pathway   • regulation of molecular function   • negative regulation of lyase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • negative regulation of molecular function   • negative regulation of catalytic activity   • negative regulation of adenylate cyclase activity   • trans-synaptic signaling   • synaptic signaling   • anterograde trans-synaptic signaling   • chemical synaptic transmission   • cellular response to stimulus   • regulation of cellular process   • response to stimulus   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • synaptic transmission, GABAergic
SCOP2Domain Identifier• Type 1 solute binding protein-like
SCOP2Family Identifier• Type 1 solute binding protein-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeNAG
PDB ResiduesH:H:?1 H:H:?2 H:H:?3 H:H:?4 H:H:?5 H:H:?6 H:H:?7 H:H:?8 H:H:?9 H:H:?10 H:H:?11
Environment DetailsOpen EMBL-EBI Page
CodeNAG
NameN-Acetylglucosamine
SynonymsN-Acetyl-D-glucosamine
Identifier
FormulaC8 H15 N O6
Molecular Weight221.208
SMILES
PubChem24139
Formal Charge0
Total Atoms30
Total Chiral Atoms5
Total Bonds30
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ9UBS5
Sequence
>6UOA_Chain_R
RRAVYIGAL FPMSGGWPG GQACQPAVE MALEDVNSR RDILPDYEL 
KLIHHDSKC DPGQATKYL YELLYNDPI KIILMPGCS SVSTLVAEA 
ARMWNLIVL SYGSSSPAL SNRQRFPTF FRTHPSATL HNPTRVKLF 
EKWGWKKIA TIQQTTEVF TSTLDDLEE RVKEAGIEI TFRQSFFSD 
PAVPVKNLK RQDARIIVG LFYETEARK VFCEVYKER LFGKKYVWF 
LIGWYADNW FKIYDPSIN CTVDEMTEA VEGHITTEI VMLNPANTR 
SISNMTSQE FVEKLTKRL KRHPEETGG FQEAPLAYD AIWALALAL 
NKTSRLEDF NYNNQTITD QIYRAMNSS SFEGVSGHV VFDASGSRM 
AWTLIEQLQ GGSYKKIGY YDSTKDDLS WSKTDKWIG GSPPADQTL 
VIKTFRFLS QKLFISVSV LSSLGIVLA VVCLSFNIY NPNLNNLTA 
VGCSLALAA VFPLGLDGY HIGRNQFPF VCQARLWLL GLGFSLGYG 
SMFTKIWWV HTVFTPWKL YATVGLLVG MDVLTLAIW QIVDPLHRT 
IETFAKEEP KEDIDVSIL PQLEHCSSR KMNTWLGIF YGYKGLLLL 
LGIFLAYET KDHRAVGMA IYNVAVLCL ITAPVTMIL SSQQDAAFA 
FASLAIVFS SYITLVVLF VPKMRRLIT


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainS
ProteinReceptor
UniProtO75899
Sequence
>6UOA_Chain_S
SPPLSIMGL MPLTKEVAK GSIGRGVLP AVELAIEQI RNESLLRPY 
FLDLRLYDT ECDNAKGLK AFYDAIKYG PNHLMVFGG VCPSVTSII 
AESLQGWNL VQLSFAATT PVLADKKKY PYFFRTVPS DNAVNPAIL 
KLLKHYQWK RVGTLTQDV QRFSEVRND LTGVLYGED IEISDTESF 
SNDPCTSVK KLKGNDVRI ILGQFDQNM AAKVFCCAY EENMYGSKY 
QWIIPGWYE PSWWEQVRC LRKNLLAAM EGYIGVDFE PLSSKQIKT 
ISGKTPQQY EREYNNKRS GVGPSKFHG YAYDGIWVI AKTLQRAME 
TLHASSRHQ RIQDFNYTD HTLGRIILN AMNETNFFG VTGQVVFRN 
GERMGTIKF TQFQDSREV KVGEYNAVA DTLEIINDT IRFQGSEPP 
KDKTIILEQ LRKISLPLY SILSALTIL GMIMASAFL FFNIKNRPY 
MNNLIILGG MLSYASIFL FGLDGSFVS EKTFETLCT VRTWILTVG 
YTTAFGAMF AKTWRVHAI FKIIKDQKL LVIVGGMLL IDLCILICW 
QAVDPLRRT VEKYSMEPD PAGRDISIR PLLEHCENT HMTIWLGIV 
YAYKGLLML FGCFLAWET RNSKYIGMS VYNVGIMCI IGAAVSFLT 
RDQPNVQFC IVALVIIFC STITLCLVF VPKLITLRT


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7EB2CAminoacidGABABGABAB2; GABAB1Homo sapiensBaclofenrac-BHFFGi1/β1/γ23.52021-05-0510.1038/s41586-021-03507-1
7EB2 (No Gprot) CAminoacidGABABGABAB2; GABAB1Homo sapiensBaclofenrac-BHFF3.52021-05-0510.1038/s41586-021-03507-1
7CUMCAminoacidGABABGABAB1, GABAB2Homo sapiensCGP54626Phospholipid-3.522020-11-1110.1016/j.jmb.2020.09.023
7CA5CAminoacidGABABGABAB1, GABAB2Homo sapiens---7.62020-11-1110.1016/j.jmb.2020.09.023
7CA3CAminoacidGABABGABAB1, GABAB2Homo sapiens-rac-BHFF-4.52020-11-1110.1016/j.jmb.2020.09.023
6W2YCAminoacidGABABGABAB1; GABAB1Homo sapiensPubChem 5311042PubChem 23727970-3.22020-07-0110.1038/s41586-020-2469-4
7C7SCAminoacidGABABGABAB1, GABAB2Homo sapiensCGP54626--2.92020-07-0110.1038/s41422-020-0350-5
7C7QCAminoacidGABABGABAB1, GABAB2Homo sapiensBaclofenPubChem 7023848-32020-07-0110.1038/s41422-020-0350-5
6WIVCAminoacidGABABGABAB1, GABAB2Homo sapiens-PubChem 52923113; PubChem 52924645-3.32020-07-0110.1038/s41586-020-2452-0
6W2XCAminoacidGABABGABAB1, GABAB2Homo sapiensPubChem 5311042PubChem 23727970-3.62020-07-0110.1038/s41586-020-2469-4
6VJMCAminoacidGABABGABAB1, GABAB2Homo sapiens---3.972020-06-1010.1038/s41586-020-2408-4
6UO9CAminoacidGABABGABAB1, GABAB2Homo sapiensSKF97541--4.82020-06-1010.1038/s41586-020-2408-4
6UO8CAminoacidGABABGABAB1, GABAB2Homo sapiensSKF97541GS39783-3.632020-06-1010.1038/s41586-020-2408-4




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 6UOA.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.