psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	A:A:R22	B:B:H91	4.51	No	Yes	0	5	5
2	A:A:S23	B:B:N88	8.94	No	Yes	0	7	7
3	A:A:S23	B:B:K89	4.59	No	Yes	0	7	9
4	A:A:K28	A:A:M25	4.32	No	No	0	4	4
5	A:A:I26	B:B:K89	7.27	No	Yes	0	9	9
6	A:A:I26	B:B:A92	3.25	No	No	0	9	6
7	A:A:E27	A:A:Q31	3.82	No	No	0	6	4
8	A:A:E27	B:B:K89	8.1	No	Yes	0	6	9
9	A:A:D33	A:A:Q29	9.14	No	No	0	5	4
10	A:A:K34	A:A:Q31	4.07	No	No	0	4	4
11	A:A:D33	B:B:K78	4.15	No	No	0	5	8
12	A:A:K34	B:B:L55	4.23	No	No	0	4	6
13	A:A:R42	A:A:Y37	21.61	No	No	0	9	4
14	A:A:Y37	B:B:L55	4.69	No	No	21	4	6
15	A:A:Y37	B:B:D76	3.45	No	Yes	21	4	9
16	A:A:N218	A:A:T40	5.85	No	No	0	4	7
17	A:A:H220	A:A:T40	4.11	No	No	0	7	7
18	A:A:F219	A:A:H41	9.05	Yes	No	0	8	6
19	A:A:H41	A:A:T242	5.48	No	No	0	6	8
20	A:A:L44	A:A:L46	5.54	No	No	0	9	8
21	A:A:F238	A:A:L44	18.27	Yes	No	0	9	9
22	A:A:I244	A:A:L44	5.71	No	No	0	8	9
23	A:A:K53	A:A:L45	5.64	Yes	No	23	9	8
24	A:A:L45	A:A:M221	4.24	No	No	0	8	8
25	A:A:D223	A:A:L45	8.14	No	No	23	9	8
26	A:A:L46	A:A:R231	3.64	No	No	0	8	9
27	A:A:G47	A:A:K53	3.49	No	Yes	0	9	9
28	A:A:A48	A:A:N50	3.13	No	Yes	0	8	9
29	A:A:D249	A:A:N50	12.12	Yes	Yes	0	8	9
30	A:A:N50	A:A:R265	8.44	Yes	No	0	9	9
31	A:A:K53	A:A:S51	4.59	Yes	No	0	9	9
32	A:A:S51	A:A:V247	4.85	No	No	0	9	7
33	A:A:G52	A:A:T55	3.64	No	No	0	9	9
34	A:A:D223	A:A:K53	9.68	No	Yes	23	9	9
35	A:A:S366	A:A:T55	3.2	No	No	0	9	9
36	A:A:R61	A:A:V57	5.23	No	No	0	8	7
37	A:A:Q59	A:A:T369	4.25	No	No	0	9	9
38	A:A:R61	A:A:T210	3.88	No	No	0	8	7
39	A:A:I62	A:A:Y63	6.04	No	No	0	9	9
40	A:A:Q213	A:A:V65	12.89	No	No	0	3	5
41	A:A:F208	A:A:S205	5.28	No	No	0	5	7
42	A:A:G206	A:A:Q227	3.29	Yes	No	0	8	9
43	A:A:G206	B:B:N119	3.39	Yes	No	0	8	9
44	A:A:F222	A:A:I207	6.28	Yes	No	1	7	9
45	A:A:I207	B:B:W99	3.52	No	Yes	1	9	9
46	A:A:I207	B:B:L117	4.28	No	No	1	9	9
47	A:A:F208	A:A:G225	4.52	No	No	0	5	9
48	A:A:E209	A:A:K211	10.8	No	No	1	9	4
49	A:A:E209	A:A:H220	4.92	No	No	1	9	7
50	A:A:E209	A:A:F222	12.83	No	Yes	1	9	7
51	A:A:H220	A:A:K211	23.58	No	No	1	7	4
52	A:A:F212	A:A:F219	9.65	No	Yes	0	9	8
53	A:A:F212	A:A:M221	4.98	No	No	0	9	8
54	A:A:N218	A:A:Q213	6.6	No	No	0	4	3
55	A:A:D215	A:A:V214	4.38	No	No	19	5	6
56	A:A:R373	A:A:V214	3.92	No	No	19	5	6
57	A:A:F376	A:A:V214	6.55	Yes	No	19	8	6
58	A:A:D215	A:A:R373	10.72	No	No	19	5	5
59	A:A:D215	A:A:F376	9.55	No	Yes	19	5	8
60	A:A:F219	A:A:V217	6.55	Yes	No	0	8	5
61	A:A:F219	A:A:F376	6.43	Yes	Yes	0	8	8
62	A:A:C379	A:A:F219	6.98	No	Yes	0	8	8
63	A:A:F222	A:A:F238	3.22	Yes	Yes	1	7	9
64	A:A:F222	B:B:W99	21.05	Yes	Yes	1	7	9
65	A:A:V224	A:A:W234	12.26	No	Yes	0	9	9
66	A:A:Q227	B:B:Y145	9.02	No	Yes	0	9	8
67	A:A:E230	A:A:R228	10.47	No	No	0	9	9
68	A:A:R228	B:B:T164	6.47	No	No	0	9	6
69	A:A:R228	B:B:D186	11.91	No	No	0	9	9
70	A:A:E230	A:A:R232	10.47	No	No	0	9	8
71	A:A:R231	A:A:W234	7	No	Yes	0	9	9
72	A:A:D272	A:A:R231	9.53	No	No	0	8	9
73	A:A:R232	B:B:C204	4.18	No	Yes	1	8	7
74	A:A:R232	B:B:D228	13.1	No	Yes	1	8	9
75	A:A:K233	B:B:Y145	3.58	Yes	Yes	1	9	8
76	A:A:K233	B:B:M188	10.08	Yes	Yes	1	9	8
77	A:A:K233	B:B:C204	4.85	Yes	Yes	1	9	7
78	A:A:K233	B:B:D228	5.53	Yes	Yes	1	9	9
79	A:A:K233	B:B:N230	6.99	Yes	No	1	9	9
80	A:A:K233	B:B:D246	5.53	Yes	No	1	9	9
81	A:A:I235	A:A:W234	3.52	No	Yes	0	9	9
82	A:A:F238	A:A:W234	4.01	Yes	Yes	0	9	9
83	A:A:Q236	A:A:W281	9.86	No	No	2	8	5
84	A:A:Q236	B:B:R314	5.84	No	Yes	2	8	8
85	A:A:C237	B:B:M101	4.86	No	Yes	0	8	9
86	A:A:F238	A:A:V241	5.24	Yes	No	0	9	9
87	A:A:F238	B:B:W99	14.03	Yes	Yes	1	9	9
88	A:A:D240	A:A:N239	5.39	No	No	2	6	8
89	A:A:N239	B:B:K57	11.19	No	Yes	2	8	9
90	A:A:N239	B:B:W332	9.04	No	Yes	2	8	9
91	A:A:D240	B:B:K57	4.15	No	Yes	2	6	9
92	A:A:C379	A:A:T242	3.38	No	No	0	8	8
93	A:A:A243	A:A:I288	3.25	No	No	0	8	9
94	A:A:I244	A:A:I285	5.89	No	No	22	8	7
95	A:A:D272	A:A:F246	4.78	No	No	0	8	9
96	A:A:F246	A:A:L289	3.65	No	Yes	0	9	9
97	A:A:A269	A:A:V248	3.39	No	No	0	9	7
98	A:A:F345	A:A:V248	9.18	Yes	No	0	8	7
99	A:A:D249	A:A:S251	5.89	Yes	No	0	8	9
100	A:A:D249	A:A:D252	3.99	Yes	No	0	8	8
101	A:A:D249	A:A:K293	16.59	Yes	No	0	8	9
102	A:A:Q294	A:A:S250	7.22	Yes	No	6	6	6
103	A:A:L297	A:A:S250	7.51	No	No	6	8	6
104	A:A:L296	A:A:S251	6.01	Yes	No	0	6	9
105	A:A:D252	A:A:N264	6.73	No	No	0	8	9
106	A:A:D252	A:A:R265	5.96	No	No	0	8	9
107	A:A:L297	A:A:Y253	3.52	No	Yes	0	8	8
108	A:A:K300	A:A:Y253	9.55	No	Yes	0	9	8
109	A:A:S306	A:A:Y253	3.82	No	Yes	0	7	8
110	A:A:I308	A:A:Y253	13.3	Yes	Yes	0	7	8
111	A:A:Y253	A:A:Y311	5.96	Yes	No	0	8	6
112	A:A:N264	A:A:Y311	11.63	No	No	0	9	6
113	A:A:E268	A:A:R265	10.47	No	No	0	9	9
114	A:A:F312	A:A:L266	6.09	Yes	No	0	8	8
115	A:A:I341	A:A:L266	5.71	No	No	0	8	8
116	A:A:L270	A:A:Q267	6.65	No	No	0	6	4
117	A:A:N271	A:A:Q267	6.6	No	No	0	5	4
118	A:A:F345	A:A:L270	7.31	Yes	No	0	8	6
119	A:A:I348	A:A:L270	5.71	No	No	0	4	6
120	A:A:F273	A:A:W277	5.01	Yes	Yes	6	9	6
121	A:A:F273	A:A:V287	6.55	Yes	No	6	9	6
122	A:A:F273	A:A:L289	3.65	Yes	Yes	6	9	9
123	A:A:F273	A:A:F345	8.57	Yes	Yes	6	9	8
124	A:A:C359	A:A:F273	5.59	No	Yes	0	5	9
125	A:A:K274	A:A:N278	6.99	No	No	0	5	8
126	A:A:I348	A:A:K274	11.63	No	No	0	4	5
127	A:A:V287	A:A:W277	4.9	No	Yes	6	6	6
128	A:A:S349	A:A:W277	9.88	No	Yes	0	7	6
129	A:A:G353	A:A:W277	4.22	No	Yes	0	4	6
130	A:A:H357	A:A:W277	22.22	No	Yes	0	7	6
131	A:A:N278	A:A:S352	4.47	No	No	0	8	5
132	A:A:L282	A:A:N279	12.36	Yes	No	0	9	8
133	A:A:R280	A:A:R283	13.86	No	No	0	5	3
134	A:A:W281	B:B:D290	6.7	No	Yes	2	5	6
135	A:A:W281	B:B:R314	25.99	No	Yes	2	5	8
136	A:A:R283	A:A:R356	7.46	No	No	0	3	2
137	A:A:I382	A:A:S286	9.29	No	No	0	6	8
138	A:A:F290	A:A:I288	3.77	Yes	No	0	9	9
139	A:A:D378	A:A:I288	12.59	No	No	0	7	9
140	A:A:L289	A:A:L291	4.15	Yes	No	6	9	8
141	A:A:F345	A:A:L289	9.74	Yes	Yes	6	8	9
142	A:A:L289	A:A:P361	3.28	Yes	No	0	9	5
143	A:A:F290	A:A:H362	6.79	Yes	No	0	9	9
144	A:A:F290	A:A:T364	10.38	Yes	Yes	16	9	9
145	A:A:F290	A:A:N371	7.25	Yes	Yes	16	9	9
146	A:A:F290	A:A:I375	5.02	Yes	No	0	9	9
147	A:A:L291	A:A:Q294	6.65	No	Yes	6	8	6
148	A:A:F363	A:A:L291	3.65	Yes	No	6	5	8
149	A:A:N292	A:A:T364	7.31	No	Yes	0	9	9
150	A:A:K293	A:A:L296	5.64	No	Yes	0	9	6
151	A:A:L297	A:A:Q294	6.65	No	Yes	6	8	6
152	A:A:K338	A:A:Q294	4.07	Yes	Yes	6	5	6
153	A:A:F363	A:A:Q294	4.68	Yes	Yes	6	5	6
154	A:A:R333	A:A:V301	3.92	No	No	0	5	7
155	A:A:V301	A:A:V334	4.81	No	Yes	0	7	4
156	A:A:D331	A:A:L302	4.07	Yes	No	0	4	2
157	A:A:A303	A:A:K305	3.21	No	No	0	5	3
158	A:A:E309	A:A:K307	14.85	No	No	0	4	6
159	A:A:D310	A:A:K307	12.44	No	No	0	3	6
160	A:A:F312	A:A:I308	3.77	Yes	Yes	13	8	7
161	A:A:F315	A:A:I308	11.3	Yes	Yes	13	6	7
162	A:A:F340	A:A:I308	5.02	Yes	Yes	13	7	7
163	A:A:E309	A:A:F315	4.66	No	Yes	0	4	6
164	A:A:D310	A:A:Y311	9.2	No	No	0	3	6
165	A:A:E314	A:A:F312	8.16	Yes	Yes	13	6	8
166	A:A:F312	A:A:F340	6.43	Yes	Yes	13	8	7
167	A:A:E314	A:A:P313	3.14	Yes	No	0	6	6
168	A:A:E314	A:A:F340	8.16	Yes	Yes	13	6	7
169	A:A:E314	A:A:E344	6.34	Yes	No	13	6	5
170	A:A:F315	A:A:R336	22.45	Yes	No	0	6	5
171	A:A:F315	A:A:F340	19.29	Yes	Yes	13	6	7
172	A:A:P321	A:A:Y318	6.95	No	Yes	0	5	6
173	A:A:R336	A:A:Y318	4.12	No	Yes	0	5	6
174	A:A:F340	A:A:Y318	16.5	Yes	Yes	0	7	6
175	A:A:D343	A:A:Y318	11.49	No	Yes	0	3	6
176	A:A:P321	A:A:T320	3.5	No	No	0	5	1
177	A:A:R336	A:A:T320	3.88	No	No	0	5	1
178	A:A:D323	A:A:P321	4.83	No	No	0	4	5
179	A:A:D323	A:A:R342	3.57	No	No	0	4	4
180	A:A:A324	A:A:Y339	9.34	No	Yes	0	3	3
181	A:A:P326	A:A:T335	10.49	No	No	0	1	4
182	A:A:E327	A:A:E330	6.34	No	Yes	6	4	3
183	A:A:E327	A:A:K338	5.4	No	Yes	6	4	5
184	A:A:E330	A:A:V334	4.28	Yes	Yes	0	3	4
185	A:A:E330	A:A:T335	7.06	Yes	No	0	3	4
186	A:A:E330	A:A:K338	6.75	Yes	Yes	6	3	5
187	A:A:D331	A:A:R333	11.91	Yes	No	0	4	5
188	A:A:D331	A:A:V334	8.76	Yes	Yes	0	4	4
189	A:A:T335	A:A:Y339	4.99	No	Yes	0	4	3
190	A:A:F363	A:A:K338	14.89	Yes	Yes	6	5	5
191	A:A:R342	A:A:Y339	9.26	No	Yes	0	4	3
192	A:A:F363	A:A:Y339	6.19	Yes	Yes	0	5	3
193	A:A:E344	A:A:F340	7	No	Yes	13	5	7
194	A:A:L346	A:A:R342	8.5	No	No	0	4	4
195	A:A:E344	A:A:R347	8.14	No	No	0	5	4
196	A:A:L346	A:A:P361	4.93	No	No	0	4	5
197	A:A:S349	A:A:T350	3.2	No	No	0	7	4
198	A:A:C359	A:A:S349	3.44	No	No	0	5	7
199	A:A:D354	A:A:R356	9.53	No	No	0	3	2
200	A:A:G355	A:A:Y358	4.35	No	No	0	2	4
201	A:A:H357	A:A:R356	3.39	No	No	0	7	2
202	A:A:R385	A:A:Y358	9.26	Yes	No	17	5	4
203	A:A:Y358	R:R:T392	4.99	No	No	17	4	7
204	A:A:D378	A:A:Y360	10.34	No	No	0	7	8
205	A:A:D381	A:A:Y360	3.45	No	No	0	8	8
206	A:A:I382	A:A:Y360	4.84	No	No	0	6	8
207	A:A:H362	A:A:R374	13.54	No	No	0	9	4
208	A:A:D378	A:A:H362	12.61	No	No	0	7	9
209	A:A:D368	A:A:T364	5.78	Yes	Yes	16	9	9
210	A:A:N371	A:A:T364	7.31	Yes	Yes	16	9	9
211	A:A:R374	A:A:T364	3.88	No	Yes	16	4	9
212	A:A:D368	A:A:E370	5.2	Yes	No	0	9	4
213	A:A:D368	A:A:N371	13.46	Yes	Yes	16	9	9
214	A:A:N371	A:A:R374	6.03	Yes	No	16	9	4
215	A:A:N377	A:A:R373	7.23	No	No	0	4	5
216	A:A:F376	A:A:N377	4.83	Yes	No	0	8	4
217	A:A:F376	A:A:R380	3.21	Yes	No	0	8	7
218	A:A:Q384	A:A:R380	3.5	No	No	0	6	7
219	A:A:D381	A:A:R385	7.15	No	Yes	17	8	5
220	A:A:D381	R:R:K388	12.44	No	Yes	17	8	9
221	A:A:Q384	R:R:K388	6.78	No	Yes	0	6	9
222	A:A:R385	R:R:K388	8.66	Yes	Yes	17	5	9
223	A:A:R385	R:R:T392	10.35	Yes	No	17	5	7
224	A:A:H387	R:R:L309	16.71	No	No	0	8	8
225	A:A:L388	A:A:L393	4.15	No	Yes	5	8	8
226	A:A:L388	R:R:I310	5.71	No	No	0	8	8
227	A:A:L388	R:R:L385	5.54	No	Yes	5	8	8
228	A:A:L394	A:A:R389	3.64	No	No	0	8	4
229	A:A:L393	A:A:Y391	3.52	Yes	Yes	5	8	4
230	A:A:Y391	R:R:R219	12.35	Yes	Yes	5	4	9
231	A:A:Y391	R:R:H223	3.27	Yes	Yes	5	4	9
232	A:A:Y391	R:R:E302	4.49	Yes	Yes	5	4	9
233	A:A:Y391	R:R:L306	16.41	Yes	No	0	4	9
234	A:A:Y391	W:W:?1	6.28	Yes	Yes	5	4	0
235	A:A:E392	W:W:?1	4.97	No	Yes	0	6	0
236	A:A:L393	R:R:L385	4.15	Yes	Yes	5	8	8
237	A:A:L393	R:R:L413	4.15	Yes	No	0	8	9
238	A:A:L394	R:R:L385	4.15	No	Yes	0	8	8
239	B:B:E3	G:G:I9	4.1	No	Yes	0	5	2
240	B:B:L4	G:G:S8	9.01	No	No	0	4	4
241	B:B:D5	B:B:R8	8.34	No	No	0	1	3
242	B:B:L7	G:G:A12	4.73	No	No	0	8	5
243	B:B:E10	G:G:V16	7.13	No	No	0	8	7
244	B:B:L14	G:G:L19	4.15	No	Yes	0	8	9
245	B:B:K15	G:G:L19	4.23	No	Yes	0	6	9
246	B:B:N16	B:B:R19	8.44	No	No	0	1	4
247	B:B:I18	B:B:R22	6.26	No	No	0	7	6
248	B:B:I18	G:G:E22	4.1	No	Yes	0	7	9
249	B:B:I18	G:G:A23	3.25	No	No	0	7	8
250	B:B:D20	B:B:K23	5.53	No	No	0	2	2
251	B:B:D258	B:B:R22	11.91	Yes	No	0	7	6
252	B:B:D27	G:G:S31	7.36	No	No	0	8	9
253	B:B:S31	B:B:T29	6.4	No	No	0	1	3
254	B:B:Q32	B:B:T29	7.09	No	No	0	1	3
255	B:B:L30	B:B:T34	5.9	No	No	0	5	5
256	B:B:L30	B:B:M262	8.48	No	Yes	0	5	4
257	B:B:L300	B:B:T34	7.37	No	No	0	6	5
258	B:B:I37	G:G:M38	4.37	No	No	0	2	4
259	B:B:D298	B:B:V40	8.76	No	No	0	9	3
260	B:B:Q44	B:B:R42	12.85	No	No	0	4	2
261	B:B:I43	B:B:L284	4.28	No	No	0	3	5
262	B:B:A305	B:B:I43	4.87	No	No	0	4	3
263	B:B:Q44	B:B:R46	11.68	No	No	0	4	5
264	B:B:L308	B:B:M45	5.65	No	No	4	7	4
265	B:B:M45	B:B:W339	5.82	No	Yes	4	4	9
266	B:B:M45	G:G:L50	4.24	No	No	4	4	9
267	B:B:R46	B:B:R48	4.26	No	No	0	5	7
268	B:B:K337	B:B:T47	12.01	Yes	No	4	6	3
269	B:B:T47	B:B:W339	8.49	No	Yes	4	3	9
270	B:B:N340	B:B:R48	6.03	Yes	No	0	9	7
271	B:B:R49	B:B:T87	5.17	No	No	0	7	5
272	B:B:R49	G:G:F61	4.28	No	Yes	0	7	8
273	B:B:R52	B:B:T50	6.47	No	No	0	7	3
274	B:B:K337	B:B:T50	9.01	Yes	No	0	6	3
275	B:B:L51	B:B:L70	4.15	No	No	11	9	5
276	B:B:L51	B:B:W82	15.94	No	Yes	11	9	9
277	B:B:L336	B:B:L51	8.3	No	No	0	7	9
278	B:B:F335	B:B:R52	9.62	No	No	4	4	7
279	B:B:R52	R:R:R213	8.53	No	No	4	7	8
280	B:B:H54	B:B:I58	6.63	Yes	No	0	9	9
281	B:B:H54	B:B:S72	5.58	Yes	No	11	9	9
282	B:B:H54	B:B:S74	12.55	Yes	No	0	9	9
283	B:B:H54	B:B:I80	11.93	Yes	Yes	11	9	8
284	B:B:H54	B:B:W82	7.41	Yes	Yes	11	9	9
285	B:B:D76	B:B:L55	10.86	Yes	No	21	9	6
286	B:B:A56	B:B:D76	4.63	No	Yes	0	7	9
287	B:B:K57	B:B:Q75	13.56	Yes	No	0	9	9
288	B:B:K57	B:B:W332	24.37	Yes	Yes	2	9	9
289	B:B:I58	B:B:L336	4.28	No	No	0	9	7
290	B:B:Q75	B:B:Y59	3.38	No	No	0	9	8
291	B:B:M101	B:B:Y59	17.96	Yes	No	0	9	8
292	B:B:M61	B:B:W63	5.82	No	Yes	0	6	7
293	B:B:C317	B:B:M61	4.86	No	No	0	7	6
294	B:B:G319	B:B:M61	3.49	No	No	0	5	6
295	B:B:H62	B:B:R150	14.67	No	No	0	6	6
296	B:B:L70	B:B:W63	9.11	No	Yes	0	5	7
297	B:B:S84	B:B:W63	6.18	No	Yes	0	5	7
298	B:B:T321	B:B:W63	9.7	Yes	Yes	0	7	7
299	B:B:A328	B:B:W63	3.89	No	Yes	0	5	7
300	B:B:G64	B:B:Y105	4.35	No	Yes	0	5	6
301	B:B:S67	B:B:T321	7.99	No	Yes	8	5	7
302	B:B:D322	B:B:S67	4.42	No	No	0	1	5
303	B:B:D323	B:B:S67	8.83	No	No	8	7	5
304	B:B:D83	B:B:R68	15.48	No	No	0	8	5
305	B:B:R68	B:B:Y85	24.69	No	No	0	5	4
306	B:B:L69	B:B:V90	4.47	No	No	0	5	5
307	B:B:L70	B:B:W82	5.69	No	Yes	11	5	9
308	B:B:L79	B:B:V71	4.47	Yes	Yes	7	7	8
309	B:B:V71	B:B:Y105	6.31	Yes	Yes	7	8	6
310	B:B:V112	B:B:V71	4.81	Yes	Yes	7	8	8
311	B:B:S72	B:B:W82	4.94	No	Yes	11	9	9
312	B:B:L336	B:B:S72	7.51	No	No	0	7	9
313	B:B:A73	B:B:C103	3.61	No	No	0	9	8
314	B:B:D76	B:B:S74	10.31	Yes	No	0	9	9
315	B:B:Q75	B:B:W99	8.76	No	Yes	0	9	9
316	B:B:D76	B:B:K78	4.15	Yes	No	0	9	8
317	B:B:G77	B:B:L95	5.13	No	Yes	0	8	8
318	B:B:K78	B:B:P94	3.35	No	No	0	8	5
319	B:B:I93	B:B:L79	8.56	Yes	Yes	7	7	7
320	B:B:L79	B:B:L95	4.15	Yes	Yes	7	7	8
321	B:B:L79	B:B:V112	4.47	Yes	Yes	7	7	8
322	B:B:I80	B:B:W82	14.09	Yes	Yes	11	8	9
323	B:B:I80	B:B:K89	4.36	Yes	Yes	11	8	9
324	B:B:H91	B:B:I81	6.63	Yes	No	0	5	7
325	B:B:I81	B:B:Y105	3.63	No	Yes	7	7	6
326	B:B:I81	B:B:L126	4.28	No	No	7	7	5
327	B:B:K89	B:B:W82	9.28	Yes	Yes	11	9	9
328	B:B:D83	B:B:T86	4.34	No	No	0	8	6
329	B:B:I338	B:B:S84	6.19	No	No	8	5	5
330	B:B:S84	G:G:F61	6.61	No	Yes	8	5	8
331	B:B:Y85	G:G:P60	12.52	No	Yes	8	4	9
332	B:B:Y85	G:G:F61	5.16	No	Yes	8	4	8
333	B:B:N88	B:B:T86	10.24	Yes	No	0	7	6
334	B:B:H91	B:B:V90	6.92	Yes	No	0	5	5
335	B:B:H91	B:B:V133	4.15	Yes	No	0	5	4
336	B:B:I93	B:B:P94	3.39	Yes	No	0	7	5
337	B:B:I93	B:B:Y124	8.46	Yes	Yes	7	7	6
338	B:B:I93	B:B:V133	6.14	Yes	No	7	7	4
339	B:B:L95	B:B:V100	4.47	Yes	No	7	8	9
340	B:B:C114	B:B:L95	4.76	No	Yes	7	8	8
341	B:B:L95	B:B:Y124	5.86	Yes	Yes	7	8	6
342	B:B:R96	B:B:V135	5.23	No	No	0	6	4
343	B:B:E138	B:B:R96	9.3	No	No	0	6	6
344	B:B:D118	B:B:S97	10.31	No	No	0	9	8
345	B:B:S98	B:B:W99	6.18	No	Yes	0	8	9
346	B:B:L117	B:B:W99	4.56	No	Yes	1	9	9
347	B:B:C114	B:B:V100	3.42	No	No	7	8	9
348	B:B:G116	B:B:M101	3.49	No	Yes	0	9	9
349	B:B:M101	B:B:Y145	4.79	Yes	Yes	0	9	8
350	B:B:C148	B:B:T102	3.38	No	No	0	6	8
351	B:B:C149	B:B:T102	6.76	No	No	0	8	8
352	B:B:G109	B:B:Y105	5.79	No	Yes	0	5	6
353	B:B:L126	B:B:Y105	3.52	No	Yes	7	5	6
354	B:B:A106	B:B:F151	5.55	No	Yes	0	6	9
355	B:B:N110	B:B:S108	10.43	No	No	0	4	6
356	B:B:D154	B:B:S108	8.83	No	No	0	6	6
357	B:B:K127	B:B:N110	18.19	No	No	0	4	4
358	B:B:N125	B:B:Y111	12.79	No	No	0	4	4
359	B:B:D154	B:B:Y111	6.9	No	No	0	6	4
360	B:B:V112	B:B:Y124	3.79	Yes	Yes	7	8	6
361	B:B:L126	B:B:V112	7.45	No	Yes	7	5	8
362	B:B:C114	B:B:Y124	4.03	No	Yes	7	8	6
363	B:B:L117	B:B:Y145	3.52	No	Yes	1	9	8
364	B:B:D118	B:B:I120	7	No	No	0	9	6
365	B:B:E138	B:B:I120	6.83	No	No	0	6	6
366	B:B:C121	B:B:L139	6.35	No	No	0	8	9
367	B:B:C121	B:B:L146	3.17	No	No	0	8	7
368	B:B:C121	B:B:C149	3.64	No	No	0	8	8
369	B:B:S122	B:B:Y124	5.09	No	Yes	0	8	6
370	B:B:E138	B:B:S122	4.31	No	No	0	6	8
371	B:B:I123	B:B:L139	4.28	Yes	No	0	6	9
372	B:B:V133	B:B:Y124	3.79	No	Yes	7	4	6
373	B:B:V135	B:B:Y124	5.05	No	Yes	0	4	6
374	B:B:N132	B:B:R134	4.82	No	No	0	3	3
375	B:B:G174	B:B:R137	6	No	No	0	4	5
376	B:B:L139	B:B:W169	20.5	No	Yes	0	9	8
377	B:B:G141	B:B:Q176	3.29	No	Yes	0	5	4
378	B:B:H142	B:B:T159	4.11	Yes	Yes	0	9	9
379	B:B:H142	B:B:S161	13.95	Yes	No	1	9	9
380	B:B:D163	B:B:H142	8.82	Yes	Yes	1	9	9
381	B:B:H142	B:B:T165	6.85	Yes	No	1	9	7
382	B:B:G144	B:B:T143	3.64	No	No	1	8	5
383	B:B:D163	B:B:T143	5.78	Yes	No	1	9	5
384	B:B:D163	B:B:G144	6.71	Yes	No	1	9	8
385	B:B:G162	B:B:Y145	4.35	No	Yes	1	9	8
386	B:B:D186	B:B:Y145	11.49	No	Yes	1	9	8
387	B:B:M188	B:B:Y145	3.59	Yes	Yes	1	8	8
388	B:B:L146	B:B:T159	4.42	No	Yes	0	7	9
389	B:B:M188	B:B:S147	4.6	Yes	No	0	8	9
390	B:B:C148	B:B:S160	3.44	No	Yes	3	6	6
391	B:B:C148	B:B:L190	7.94	No	No	3	6	5
392	B:B:L192	B:B:R150	4.86	No	No	0	5	6
393	B:B:F151	B:B:I157	6.28	Yes	No	0	9	7
394	B:B:L152	B:B:Q156	6.65	Yes	No	0	3	5
395	B:B:L152	B:B:V158	4.47	Yes	No	3	3	5
396	B:B:L152	B:B:L192	5.54	Yes	No	3	3	5
397	B:B:D153	B:B:Q156	3.92	No	No	0	5	5
398	B:B:I171	B:B:N155	5.66	No	No	0	6	3
399	B:B:L168	B:B:Q156	13.31	No	No	0	6	5
400	B:B:L192	B:B:V158	4.47	No	No	3	5	5
401	B:B:F199	B:B:V158	5.24	Yes	No	3	9	5
402	B:B:T159	B:B:W169	4.85	Yes	Yes	0	9	8
403	B:B:C166	B:B:S160	3.44	No	Yes	3	8	6
404	B:B:S160	B:B:V187	8.08	Yes	Yes	3	6	9
405	B:B:L190	B:B:S160	6.01	No	Yes	3	5	6
406	B:B:G162	B:B:S161	3.71	No	No	1	9	9
407	B:B:D163	B:B:S161	10.31	Yes	No	1	9	9
408	B:B:D186	B:B:G162	6.71	No	No	1	9	9
409	B:B:D163	B:B:T165	13.01	Yes	No	1	9	7
410	B:B:T165	B:B:T181	3.14	No	No	0	7	2
411	B:B:C166	B:B:F180	4.19	No	Yes	3	8	7
412	B:B:C166	B:B:V187	5.12	No	Yes	3	8	9
413	B:B:A167	B:B:W169	3.89	No	Yes	24	4	8
414	B:B:A167	B:B:Q176	4.55	No	Yes	24	4	4
415	B:B:L168	B:B:T178	4.42	No	No	0	6	4
416	B:B:Q176	B:B:W169	13.14	Yes	Yes	24	4	8
417	B:B:D170	B:B:T173	10.12	No	No	0	9	5
418	B:B:D170	B:B:T177	4.34	No	No	0	9	4
419	B:B:Q175	B:B:T173	4.25	No	No	0	4	5
420	B:B:Q176	B:B:T179	7.09	Yes	No	0	4	4
421	B:B:F180	B:B:T178	5.19	Yes	No	0	7	4
422	B:B:F180	B:B:F199	8.57	Yes	Yes	3	7	9
423	B:B:F180	B:B:W211	18.04	Yes	Yes	3	7	8
424	B:B:F180	B:B:G216	4.52	Yes	No	0	7	4
425	B:B:H183	B:B:V187	5.54	Yes	Yes	3	9	9
426	B:B:A203	B:B:H183	8.78	No	Yes	3	8	9
427	B:B:D205	B:B:H183	10.08	Yes	Yes	3	9	9
428	B:B:H183	B:B:K209	10.48	Yes	Yes	3	9	6
429	B:B:D205	B:B:T184	5.78	Yes	No	0	9	3
430	B:B:D205	B:B:G185	5.03	Yes	No	0	9	5
431	B:B:S201	B:B:V187	3.23	No	Yes	0	9	9
432	B:B:A203	B:B:V187	5.09	No	Yes	3	8	9
433	B:B:C204	B:B:M188	3.24	Yes	Yes	1	7	8
434	B:B:I232	B:B:S189	4.64	No	No	0	8	7
435	B:B:F234	B:B:S191	6.61	No	No	0	5	8
436	B:B:A193	B:B:F234	6.93	No	No	0	4	5
437	B:B:G238	B:B:P194	4.06	No	No	0	7	4
438	B:B:D195	B:B:R197	3.57	No	No	0	5	5
439	B:B:L198	B:B:L210	4.15	No	Yes	0	3	5
440	B:B:F199	B:B:W211	10.02	Yes	Yes	3	9	8
441	B:B:L210	B:B:V200	4.47	Yes	Yes	0	5	6
442	B:B:I232	B:B:V200	6.14	No	Yes	10	8	6
443	B:B:F234	B:B:V200	9.18	No	Yes	0	5	6
444	B:B:F241	B:B:V200	14.42	Yes	Yes	10	6	6
445	B:B:G202	B:B:S201	3.71	No	No	0	6	9
446	B:B:S201	B:B:W211	4.94	No	Yes	0	9	8
447	B:B:G202	B:B:I229	3.53	No	No	0	6	7
448	B:B:A203	B:B:D205	4.63	No	Yes	3	8	9
449	B:B:C204	B:B:D228	10.89	Yes	Yes	1	7	9
450	B:B:D205	B:B:S207	8.83	Yes	No	0	9	5
451	B:B:K209	B:B:W211	5.8	Yes	Yes	3	6	8
452	B:B:C218	B:B:K209	4.85	No	Yes	3	5	6
453	B:B:K209	B:B:T221	10.51	Yes	No	0	6	7
454	B:B:L210	B:B:R219	4.86	Yes	No	0	5	5
455	B:B:L210	B:B:Q220	3.99	Yes	No	0	5	7
456	B:B:L210	B:B:L255	8.3	Yes	No	0	5	6
457	B:B:C218	B:B:W211	5.22	No	Yes	3	5	8
458	B:B:D212	B:B:E215	6.5	No	No	25	9	3
459	B:B:D212	B:B:R219	10.72	No	No	25	9	5
460	B:B:E215	B:B:R219	9.3	No	No	25	3	5
461	B:B:C218	G:G:Q18	6.1	No	No	0	5	9
462	B:B:F222	B:B:Q220	7.03	Yes	No	10	8	7
463	B:B:D258	B:B:Q220	9.14	Yes	No	10	7	7
464	B:B:T221	G:G:E22	5.64	No	Yes	0	7	9
465	B:B:F222	B:B:F241	9.65	Yes	Yes	10	8	6
466	B:B:F222	B:B:F253	15	Yes	Yes	10	8	6
467	B:B:D258	B:B:F222	4.78	Yes	Yes	10	7	8
468	B:B:H225	B:B:I229	5.3	Yes	No	14	9	7
469	B:B:H225	B:B:T243	6.85	Yes	No	0	9	8
470	B:B:H225	B:B:S245	13.95	Yes	No	14	9	9
471	B:B:D247	B:B:H225	7.56	Yes	Yes	14	9	9
472	B:B:H225	B:B:R251	21.44	Yes	Yes	14	9	8
473	B:B:D247	B:B:E226	5.2	Yes	No	0	9	3
474	B:B:D228	B:B:S227	4.42	Yes	No	0	9	6
475	B:B:D246	B:B:S227	5.89	No	No	0	9	6
476	B:B:D247	B:B:S227	4.42	Yes	No	0	9	6
477	B:B:I229	B:B:S245	4.64	No	No	14	7	9
478	B:B:D246	B:B:N230	9.42	No	No	1	9	9
479	B:B:A231	B:B:V276	3.39	No	No	0	5	6
480	B:B:F241	B:B:I232	6.28	Yes	No	10	6	8
481	B:B:C233	B:B:V276	5.12	No	No	0	3	6
482	B:B:C233	B:B:F278	4.19	No	Yes	0	3	7
483	B:B:F235	B:B:P236	20.23	Yes	No	9	6	7
484	B:B:F235	B:B:N237	12.08	Yes	Yes	9	6	5
485	B:B:F235	B:B:F278	11.79	Yes	Yes	0	6	7
486	B:B:F235	B:B:G282	4.52	Yes	No	9	6	9
487	B:B:F235	G:G:L37	4.87	Yes	No	9	6	7
488	B:B:F235	G:G:Y40	6.19	Yes	Yes	9	6	6
489	B:B:G282	B:B:P236	4.06	No	No	9	9	7
490	B:B:P236	G:G:Y40	11.13	No	Yes	9	7	6
491	B:B:G238	B:B:N237	3.39	No	Yes	0	7	5
492	B:B:N237	B:B:N239	8.17	Yes	No	9	5	2
493	B:B:N237	G:G:D36	4.04	Yes	No	9	5	5
494	B:B:N237	G:G:L37	5.49	Yes	No	9	5	7
495	B:B:N237	G:G:Y40	6.98	Yes	Yes	9	5	6
496	B:B:N239	G:G:D36	4.04	No	No	9	2	5
497	B:B:A240	G:G:L37	4.73	No	No	0	6	7
498	B:B:F241	B:B:F253	9.65	Yes	Yes	10	6	6
499	B:B:A242	B:B:F278	4.16	No	Yes	0	4	7
500	B:B:F253	B:B:T243	9.08	Yes	No	0	6	8
501	B:B:G244	B:B:I273	5.29	No	No	0	5	6
502	B:B:D247	B:B:S245	7.36	Yes	No	14	9	9
503	B:B:D247	B:B:T249	5.78	Yes	No	14	9	6
504	B:B:D247	B:B:R251	3.57	Yes	Yes	14	9	8
505	B:B:R251	B:B:T249	7.76	Yes	No	14	8	6
506	B:B:S265	B:B:T249	6.4	No	No	0	2	6
507	B:B:C250	B:B:Y264	4.03	No	Yes	0	8	5
508	B:B:C250	B:B:I273	3.27	No	No	0	8	6
509	B:B:E260	B:B:R251	6.98	No	Yes	0	6	8
510	B:B:R251	B:B:T263	7.76	Yes	No	0	8	1
511	B:B:L252	B:B:L261	8.3	No	No	0	7	5
512	B:B:L252	B:B:Y264	7.03	No	Yes	0	7	5
513	B:B:E260	B:B:F253	3.5	No	Yes	0	6	6
514	B:B:D254	B:B:R256	4.76	No	Yes	9	9	9
515	B:B:D254	B:B:L261	6.79	No	No	0	9	5
516	B:B:D254	G:G:A33	6.18	No	No	9	9	7
517	B:B:R256	G:G:I28	12.53	Yes	No	0	9	4
518	B:B:R256	G:G:K32	3.71	Yes	No	0	9	5
519	B:B:R256	G:G:A33	4.15	Yes	No	9	9	7
520	B:B:R256	G:G:D36	4.76	Yes	No	9	9	5
521	B:B:A257	G:G:V30	5.09	No	No	0	7	8
522	B:B:D258	G:G:R27	5.96	Yes	No	0	7	8
523	B:B:Q259	G:G:V30	5.73	No	No	0	6	8
524	B:B:M262	B:B:Y264	7.18	Yes	Yes	0	4	5
525	B:B:A302	B:B:M262	3.22	No	Yes	0	2	4
526	B:B:S265	B:B:T263	3.2	No	No	0	2	1
527	B:B:L285	B:B:Y264	4.69	No	Yes	2	6	5
528	B:B:W297	B:B:Y264	6.75	Yes	Yes	2	8	5
529	B:B:H266	B:B:I269	3.98	Yes	No	0	4	4
530	B:B:H266	B:B:R304	4.51	Yes	Yes	0	4	5
531	B:B:I269	B:B:Y289	4.84	No	Yes	0	4	7
532	B:B:C271	B:B:Y289	4.03	No	Yes	2	5	7
533	B:B:C271	B:B:D290	6.22	No	Yes	2	5	6
534	B:B:C271	B:B:D291	7.78	No	No	2	5	8
535	B:B:D290	B:B:G272	3.35	Yes	No	0	6	4
536	B:B:I273	B:B:Y289	4.84	No	Yes	0	6	7
537	B:B:S275	B:B:T274	3.2	No	No	0	8	8
538	B:B:D290	B:B:T274	4.34	Yes	No	2	6	8
539	B:B:R314	B:B:T274	5.17	Yes	No	2	8	8
540	B:B:L318	B:B:S275	9.01	No	No	0	6	8
541	B:B:A287	B:B:V276	3.39	No	No	0	6	6
542	B:B:S277	B:B:V320	4.85	No	No	0	5	7
543	B:B:F278	B:B:L285	14.61	Yes	No	0	7	6
544	B:B:L284	B:B:S279	6.01	No	No	0	5	9
545	B:B:S279	G:G:D48	5.89	No	Yes	4	9	9
546	B:B:S279	G:G:L50	4.5	No	No	4	9	9
547	B:B:K280	G:G:D48	4.15	No	Yes	0	1	9
548	B:B:S281	G:G:D48	8.83	No	Yes	0	9	9
549	B:B:D298	B:B:R283	14.29	No	No	0	9	9
550	B:B:L300	B:B:R283	8.5	No	No	0	6	9
551	B:B:L284	B:B:V296	4.47	No	No	0	5	5
552	B:B:L285	B:B:W297	3.42	No	Yes	2	6	8
553	B:B:L286	B:B:V327	4.47	No	No	0	7	6
554	B:B:A287	B:B:Y289	4	No	Yes	0	6	7
555	B:B:D291	B:B:Y289	3.45	No	Yes	2	8	7
556	B:B:N295	B:B:Y289	10.47	Yes	Yes	2	6	7
557	B:B:W297	B:B:Y289	9.65	Yes	Yes	2	8	7
558	B:B:D290	B:B:R314	13.1	Yes	Yes	2	6	8
559	B:B:D291	B:B:N293	13.46	No	No	2	8	5
560	B:B:N293	B:B:N295	4.09	No	Yes	2	5	6
561	B:B:N293	B:B:V307	5.91	No	No	2	5	3
562	B:B:C294	B:B:L308	4.76	No	No	0	5	7
563	B:B:C294	B:B:V315	5.12	No	No	0	5	7
564	B:B:C294	B:B:T329	5.07	No	No	0	5	8
565	B:B:N295	B:B:R304	9.64	Yes	Yes	0	6	5
566	B:B:N295	B:B:V307	5.91	Yes	No	2	6	3
567	B:B:A305	B:B:V296	3.39	No	No	0	4	5
568	B:B:R304	B:B:W297	10	Yes	Yes	0	5	8
569	B:B:D298	B:B:K301	6.91	No	No	0	9	5
570	B:B:L308	B:B:W339	25.06	No	Yes	4	7	9
571	B:B:H311	B:B:V315	5.54	Yes	No	4	9	7
572	B:B:H311	B:B:T329	8.21	Yes	No	0	9	8
573	B:B:H311	B:B:S331	12.55	Yes	No	4	9	9
574	B:B:D333	B:B:H311	11.35	Yes	Yes	4	9	9
575	B:B:H311	B:B:K337	7.86	Yes	Yes	4	9	6
576	B:B:D312	R:R:R214	8.34	No	No	0	5	7
577	B:B:N313	B:B:W332	5.65	No	Yes	0	7	9
578	B:B:R314	B:B:W332	18.99	Yes	Yes	2	8	9
579	B:B:S331	B:B:V315	6.46	No	No	4	9	7
580	B:B:C317	B:B:S316	3.44	No	No	0	7	9
581	B:B:S316	B:B:W332	6.18	No	Yes	0	9	9
582	B:B:V320	B:B:V327	3.21	No	No	0	7	6
583	B:B:D323	B:B:T321	5.78	No	Yes	8	7	7
584	B:B:G324	B:B:T321	3.64	No	Yes	0	9	7
585	B:B:D323	B:B:M325	4.16	No	Yes	8	7	5
586	B:B:G324	G:G:P49	4.06	No	Yes	0	9	7
587	B:B:M325	G:G:P49	6.71	Yes	Yes	0	5	7
588	B:B:M325	G:G:P60	5.03	Yes	Yes	8	5	9
589	B:B:M325	G:G:F61	3.73	Yes	Yes	8	5	8
590	B:B:A326	B:B:N340	3.13	No	Yes	8	7	9
591	B:B:A326	G:G:F61	5.55	No	Yes	8	7	8
592	B:B:V327	B:B:W339	3.68	No	Yes	0	6	9
593	B:B:A328	B:B:I338	3.25	No	No	0	5	5
594	B:B:T329	B:B:W339	7.28	No	Yes	0	8	9
595	B:B:D333	B:B:S331	8.83	Yes	No	4	9	9
596	B:B:D333	B:B:F335	10.75	Yes	No	4	9	4
597	B:B:F335	R:R:R213	4.28	No	No	4	4	8
598	B:B:K337	B:B:W339	6.96	Yes	Yes	4	6	9
599	B:B:I338	G:G:F61	5.02	No	Yes	8	5	8
600	B:B:N340	G:G:N59	4.09	Yes	No	0	9	9
601	B:B:N340	G:G:F61	4.83	Yes	Yes	8	9	8
602	G:G:I9	G:G:R13	6.26	Yes	No	0	2	6
603	G:G:A10	G:G:R13	4.15	No	No	0	2	6
604	G:G:E17	G:G:K20	9.45	No	No	0	6	6
605	G:G:E22	G:G:Q18	3.82	Yes	No	0	9	9
606	G:G:E22	G:G:L19	10.6	Yes	Yes	0	9	9
607	G:G:I25	G:G:R27	11.27	No	No	0	2	8
608	G:G:A35	G:G:K32	3.21	No	No	0	2	5
609	G:G:H44	G:G:Y40	15.24	No	Yes	0	6	6
610	G:G:E47	G:G:K46	10.8	No	No	0	3	1
611	G:G:D48	G:G:P49	4.83	Yes	Yes	0	9	7
612	G:G:D48	G:G:L50	4.07	Yes	No	4	9	9
613	G:G:P49	G:G:V54	3.53	Yes	No	0	7	6
614	G:G:P55	G:G:V54	3.53	No	No	0	5	6
615	G:G:N59	G:G:V54	7.39	No	No	0	9	6
616	G:G:E58	G:G:P55	7.86	No	No	0	5	5
617	G:G:E58	G:G:S57	5.75	No	No	0	5	6
618	G:G:N59	G:G:P60	4.89	No	Yes	0	9	9
619	G:G:F61	G:G:P60	7.22	Yes	Yes	8	8	9
620	R:R:D185	R:R:R186	7.15	No	No	0	2	5
621	R:R:M189	R:R:R186	9.93	No	No	0	4	5
622	R:R:H442	R:R:L187	3.86	No	No	0	5	5
623	R:R:Y191	R:R:Y195	14.89	No	Yes	0	7	7
624	R:R:M445	R:R:Y191	8.38	No	No	0	6	7
625	R:R:F450	R:R:G194	4.52	Yes	No	0	7	9
626	R:R:I237	R:R:Y195	14.51	No	Yes	0	7	7
627	R:R:S449	R:R:Y195	3.82	No	Yes	0	9	7
628	R:R:F453	R:R:V197	9.18	Yes	No	0	6	5
629	R:R:G452	R:R:S198	3.71	No	No	0	9	9
630	R:R:F453	R:R:S201	3.96	Yes	No	0	6	8
631	R:R:A456	R:R:S201	3.42	No	No	0	8	8
632	R:R:F230	R:R:L202	4.87	Yes	No	0	8	9
633	R:R:L202	R:R:M231	5.65	No	Yes	0	9	8
634	R:R:G452	R:R:L202	5.13	No	No	0	9	9
635	R:R:M231	R:R:T203	4.52	Yes	No	0	8	3
636	R:R:A205	R:R:C460	3.61	No	No	0	9	9
637	R:R:L209	R:R:N220	4.12	No	No	0	7	9
638	R:R:L209	R:R:M224	4.24	No	No	0	7	5
639	R:R:F227	R:R:L209	4.87	No	No	0	9	7
640	R:R:F212	R:R:Y211	11.35	Yes	No	0	7	2
641	R:R:F212	R:R:S473	6.61	Yes	No	0	7	4
642	R:R:H216	R:R:R213	3.39	No	No	0	8	8
643	R:R:E469	R:R:R214	8.14	No	No	0	9	7
644	R:R:L215	R:R:N220	4.12	No	No	0	9	9
645	R:R:E469	R:R:L215	6.63	No	No	0	9	9
646	R:R:H216	R:R:Y221	10.89	No	No	0	8	7
647	R:R:T218	R:R:Y305	9.99	Yes	Yes	0	7	8
648	R:R:E317	R:R:T218	7.06	No	Yes	0	6	7
649	R:R:L321	R:R:T218	7.37	No	Yes	0	6	7
650	R:R:N220	R:R:R219	4.82	No	Yes	0	9	9
651	R:R:H223	R:R:R219	9.03	Yes	Yes	5	9	9
652	R:R:E465	R:R:R219	10.47	No	Yes	0	9	9
653	R:R:R219	W:W:?1	3.25	Yes	Yes	5	9	0
654	R:R:E302	R:R:I222	13.66	Yes	No	0	9	9
655	R:R:I222	R:R:Y305	7.25	No	Yes	0	9	8
656	R:R:E302	R:R:H223	13.54	Yes	Yes	5	9	9
657	R:R:H223	W:W:?1	13.77	Yes	Yes	5	9	0
658	R:R:H225	R:R:W298	17.98	No	Yes	15	8	9
659	R:R:H225	R:R:T325	9.58	No	No	15	8	5
660	R:R:H225	R:R:W329	6.35	No	Yes	15	8	9
661	R:R:F230	R:R:L226	4.87	Yes	No	0	8	9
662	R:R:S229	R:R:T294	4.8	No	Yes	0	9	8
663	R:R:N295	R:R:S229	7.45	No	No	0	8	9
664	R:R:F230	R:R:N295	22.96	Yes	No	0	8	8
665	R:R:F230	R:R:Q451	9.37	Yes	Yes	0	8	9
666	R:R:F230	R:R:V455	5.24	Yes	No	0	8	9
667	R:R:F291	R:R:L232	18.27	Yes	No	0	5	8
668	R:R:L292	R:R:R233	4.86	Yes	Yes	0	6	8
669	R:R:N295	R:R:R233	7.23	No	Yes	0	8	8
670	R:R:N448	R:R:R233	4.82	No	Yes	0	6	8
671	R:R:Q451	R:R:R233	9.35	Yes	Yes	0	9	8
672	R:R:F291	R:R:S236	7.93	Yes	No	0	5	7
673	R:R:F288	R:R:I237	5.02	Yes	No	0	7	7
674	R:R:F288	R:R:K240	12.41	Yes	No	0	7	7
675	R:R:G277	R:R:R282	4.5	No	No	0	4	8
676	R:R:C281	R:R:C351	7.28	No	No	0	9	9
677	R:R:N348	R:R:R282	9.64	No	No	0	7	8
678	R:R:R282	R:R:W352	26.99	No	Yes	0	8	8
679	R:R:D353	R:R:V285	4.38	No	No	0	5	6
680	R:R:T286	R:R:V340	4.76	No	No	0	7	5
681	R:R:F287	R:R:F291	4.29	No	Yes	0	3	5
682	R:R:F288	R:R:L289	3.65	Yes	No	0	7	7
683	R:R:F288	R:R:L292	3.65	Yes	Yes	0	7	6
684	R:R:L289	R:R:W339	6.83	No	Yes	0	7	8
685	R:R:F291	R:R:Y290	8.25	Yes	Yes	0	5	9
686	R:R:T294	R:R:Y290	8.74	Yes	Yes	15	8	9
687	R:R:W329	R:R:Y290	7.72	Yes	Yes	15	9	9
688	R:R:A333	R:R:Y290	5.34	No	Yes	0	5	9
689	R:R:V336	R:R:Y290	5.05	No	Yes	0	7	9
690	R:R:L292	R:R:Y296	3.52	Yes	Yes	12	6	7
691	R:R:L292	R:R:Y421	5.86	Yes	Yes	12	6	8
692	R:R:A293	R:R:P332	3.74	No	No	0	6	9
693	R:R:A293	R:R:I367	3.25	No	No	0	6	7
694	R:R:T294	R:R:W329	6.06	Yes	Yes	15	8	9
695	R:R:P332	R:R:T294	3.5	No	Yes	0	9	8
696	R:R:I367	R:R:Y296	6.04	No	Yes	12	7	7
697	R:R:I371	R:R:Y296	4.84	Yes	Yes	12	7	7
698	R:R:Y296	R:R:Y421	9.93	Yes	Yes	12	7	8
699	R:R:F327	R:R:Y297	5.16	No	Yes	18	5	6
700	R:R:L331	R:R:Y297	10.55	No	Yes	18	4	6
701	R:R:P332	R:R:Y297	15.3	No	Yes	0	9	6
702	R:R:F335	R:R:Y297	4.13	No	Yes	18	5	6
703	R:R:P366	R:R:Y297	5.56	No	Yes	18	9	6
704	R:R:V301	R:R:W298	6.13	No	Yes	0	8	9
705	R:R:T325	R:R:W298	3.64	No	Yes	15	5	9
706	R:R:W298	R:R:W329	24.37	Yes	Yes	15	9	9
707	R:R:I299	R:R:N374	4.25	No	No	0	9	9
708	R:R:I299	W:W:?1	6.88	No	Yes	0	9	0
709	R:R:L300	R:R:L304	5.54	No	No	0	8	5
710	R:R:L300	R:R:S370	7.51	No	No	0	8	7
711	R:R:L300	R:R:L373	8.3	No	No	0	8	7
712	R:R:F324	R:R:V301	3.93	No	No	0	7	8
713	R:R:E302	W:W:?1	7.1	Yes	Yes	5	9	0
714	R:R:L304	R:R:L377	4.15	No	No	0	5	7
715	R:R:L309	R:R:Y305	15.24	No	Yes	0	8	8
716	R:R:F315	R:R:Y305	4.13	No	Yes	0	6	8
717	R:R:F324	R:R:Y305	6.19	No	Yes	0	7	8
718	R:R:I381	R:R:L306	4.28	No	No	0	9	9
719	R:R:F311	R:R:H307	21.5	No	No	26	6	8
720	R:R:H307	R:R:L377	6.43	No	No	0	8	7
721	R:R:H307	R:R:N380	8.93	No	No	26	8	8
722	R:R:F315	R:R:S308	5.28	No	No	0	6	7
723	R:R:F311	R:R:I310	3.77	No	No	0	6	8
724	R:R:F311	R:R:N380	4.83	No	No	26	6	8
725	R:R:F315	R:R:Y320	19.6	No	No	0	6	4
726	R:R:E317	R:R:K318	5.4	No	No	0	6	5
727	R:R:F327	R:R:G328	4.52	No	No	0	5	9
728	R:R:F327	R:R:L331	6.09	No	No	18	5	4
729	R:R:F335	R:R:L331	8.53	No	No	18	5	4
730	R:R:F335	R:R:P366	14.45	No	No	18	5	9
731	R:R:V340	R:R:W339	3.68	No	Yes	20	5	8
732	R:R:R343	R:R:W339	5	No	Yes	20	8	8
733	R:R:W339	R:R:W352	7.5	Yes	Yes	20	8	8
734	R:R:I362	R:R:W339	8.22	No	Yes	0	8	8
735	R:R:I363	R:R:W339	5.87	No	Yes	0	7	8
736	R:R:V340	R:R:W352	3.68	No	Yes	20	5	8
737	R:R:I362	R:R:V342	4.61	No	No	0	8	5
738	R:R:R343	R:R:W352	21.99	No	Yes	20	8	8
739	R:R:R343	R:R:S356	9.22	No	No	0	8	4
740	R:R:A344	R:R:N348	3.13	No	No	0	4	7
741	R:R:K359	R:R:L346	8.46	No	No	0	3	3
742	R:R:C351	R:R:D353	6.22	No	No	0	9	5
743	R:R:K360	R:R:S355	12.24	No	No	0	7	7
744	R:R:K359	R:R:S356	4.59	No	No	0	3	4
745	R:R:N358	R:R:W361	4.52	No	No	0	4	8
746	R:R:K360	R:R:W361	6.96	No	No	0	7	8
747	R:R:Q364	R:R:W361	3.29	No	No	0	7	8
748	R:R:Q364	R:R:Y421	10.15	No	Yes	12	7	8
749	R:R:M425	R:R:Q364	4.08	No	No	12	6	7
750	R:R:P366	R:R:V365	3.53	No	No	0	9	5
751	R:R:I367	R:R:Y421	8.46	No	Yes	12	7	8
752	R:R:G418	R:R:I371	7.05	No	Yes	0	9	7
753	R:R:I371	R:R:Y421	3.63	Yes	Yes	12	7	8
754	R:R:N374	R:R:P415	3.26	No	No	0	9	9
755	R:R:F375	R:R:F378	3.22	No	Yes	0	7	9
756	R:R:F375	R:R:I379	5.02	No	No	0	7	5
757	R:R:F378	R:R:V382	3.93	Yes	No	27	9	7
758	R:R:F378	R:R:T410	3.89	Yes	No	27	9	9
759	R:R:F378	R:R:P415	14.45	Yes	No	0	9	9
760	R:R:N380	R:R:R383	7.23	No	No	0	8	8
761	R:R:I381	R:R:L385	4.28	No	Yes	0	9	8
762	R:R:I381	R:R:L413	4.28	No	No	0	9	9
763	R:R:T410	R:R:V382	3.17	No	No	27	9	7
764	R:R:R383	R:R:V384	3.92	No	No	0	8	8
765	R:R:E391	R:R:T387	4.23	No	No	0	7	7
766	R:R:L389	R:R:Q402	9.32	No	No	0	8	6
767	R:R:L389	R:R:L406	4.15	No	No	0	8	8
768	R:R:Q402	R:R:T399	4.25	No	No	0	6	6
769	R:R:R400	R:R:R404	7.46	No	No	0	8	6
770	R:R:L407	R:R:R404	3.64	No	No	0	8	6
771	R:R:K408	R:R:R404	7.43	No	No	0	8	6
772	R:R:L407	R:R:L411	4.15	No	No	0	8	8
773	R:R:K408	R:R:V412	4.55	No	No	0	8	8
774	R:R:M414	R:R:P415	3.35	No	No	0	8	9
775	R:R:L416	R:R:M414	4.24	Yes	No	0	9	8
776	R:R:H420	R:R:L416	7.71	Yes	Yes	0	8	9
777	R:R:L416	W:W:?1	5.19	Yes	Yes	0	9	0
778	R:R:F417	R:R:F447	7.5	No	Yes	5	9	5
779	R:R:F417	R:R:Q451	22.25	No	Yes	5	9	9
780	R:R:F417	W:W:?1	19.56	No	Yes	5	9	0
781	R:R:F424	R:R:H420	4.53	Yes	Yes	5	7	8
782	R:R:H420	R:R:Y443	7.62	Yes	No	5	8	4
783	R:R:F447	R:R:H420	15.84	Yes	Yes	5	5	8
784	R:R:M425	R:R:Y421	3.59	No	Yes	12	6	8
785	R:R:F424	R:R:V423	3.93	Yes	No	0	7	6
786	R:R:F424	R:R:Y443	4.13	Yes	No	5	7	4
787	R:R:E444	R:R:F424	24.49	No	Yes	0	7	7
788	R:R:F424	R:R:F447	6.43	Yes	Yes	5	7	5
789	R:R:P428	R:R:T427	3.5	No	No	0	7	5
790	R:R:Q440	R:R:T427	15.59	No	No	0	6	5
791	R:R:Q440	R:R:W437	3.29	No	No	28	6	5
792	R:R:M441	R:R:W437	13.96	No	No	28	6	5
793	R:R:H442	R:R:Q438	13.6	No	No	0	5	4
794	R:R:M441	R:R:Q440	6.8	No	No	28	6	6
795	R:R:E444	R:R:M445	4.06	No	No	0	7	6
796	R:R:F447	R:R:N448	4.83	Yes	No	0	5	6
797	R:R:F447	R:R:Q451	8.2	Yes	Yes	5	5	9
798	R:R:F450	R:R:S449	6.61	Yes	No	0	7	9
799	R:R:F450	R:R:F453	3.22	Yes	Yes	0	7	6
800	R:R:F450	R:R:F454	5.36	Yes	No	0	7	6
801	R:R:F453	R:R:I457	12.56	Yes	No	0	6	6
802	R:R:V455	R:R:Y459	5.05	No	No	0	9	8
803	R:R:F461	R:R:I457	3.77	No	No	0	8	6
804	R:R:I458	W:W:?1	4.59	No	Yes	0	8	0
805	R:R:Y459	W:W:?1	25.74	No	Yes	0	8	0
806	R:R:E465	R:R:N463	3.94	No	Yes	0	9	9
807	R:R:N463	R:R:V466	5.91	Yes	No	0	9	9
808	R:R:N463	W:W:?1	19.12	Yes	Yes	0	9	0
809	R:R:E469	R:R:K472	8.1	No	No	0	9	7
810	R:R:T478	R:R:W474	6.06	No	No	0	4	5
811	R:R:L481	R:R:W477	6.83	No	No	0	4	4
812	A:A:C365	A:A:D368	3.11	No	Yes	0	8	9
813	B:B:I123	B:B:S136	3.1	Yes	No	0	6	4
814	B:B:A193	B:B:D195	3.09	No	No	0	4	5
815	R:R:I376	R:R:V372	3.07	No	No	0	4	4
816	R:R:I470	R:R:V466	3.07	No	No	0	5	9
817	R:R:K319	R:R:S316	3.06	No	No	0	6	7
818	B:B:I157	B:B:T159	3.04	No	Yes	0	7	9
819	R:R:M231	R:R:V206	3.04	Yes	No	0	8	5
820	B:B:A26	B:B:Q259	3.03	No	No	0	3	6
821	B:B:T34	G:G:M38	3.01	No	No	0	5	4
822	R:R:M189	R:R:T192	3.01	No	No	0	4	7
823	B:B:T181	G:G:K14	3	No	No	0	2	4
824	A:A:N50	A:A:S51	2.98	Yes	No	0	9	9
825	R:R:L199	R:R:V235	2.98	No	No	0	7	4
826	R:R:L228	R:R:V206	2.98	No	No	0	4	5
827	R:R:L289	R:R:V285	2.98	No	No	0	7	6
828	R:R:L436	R:R:V439	2.98	No	No	0	4	5
829	B:B:L152	B:B:T196	2.95	Yes	No	0	3	1
830	B:B:L168	B:B:T177	2.95	No	No	0	6	4
831	G:G:L51	G:G:T52	2.95	No	No	0	6	4
832	A:A:I245	A:A:I375	2.94	No	No	0	7	9
833	A:A:D295	A:A:S366	2.94	No	No	0	9	9
834	G:G:A43	G:G:H44	2.93	No	No	0	4	6
835	A:A:I26	A:A:L30	2.85	No	No	0	9	5
836	A:A:L30	B:B:I80	2.85	No	Yes	0	5	8
837	A:A:I245	A:A:L43	2.85	No	No	0	7	7
838	A:A:I235	A:A:L282	2.85	No	Yes	0	9	9
839	A:A:I244	A:A:L282	2.85	No	Yes	22	8	9
840	A:A:I285	A:A:L282	2.85	No	Yes	22	7	9
841	B:B:L4	G:G:I9	2.85	No	Yes	0	4	2
842	B:B:L7	G:G:I9	2.85	No	Yes	0	8	2
843	A:A:I56	A:A:N292	2.83	No	No	0	7	9
844	R:R:L199	R:R:M231	2.83	No	Yes	0	7	8
845	R:R:L368	R:R:M425	2.83	No	No	0	4	6
846	A:A:E370	A:A:T369	2.82	No	No	0	4	9
847	B:B:G182	B:B:W211	2.81	No	Yes	0	6	8
848	B:B:G310	B:B:W339	2.81	No	Yes	0	5	9
849	A:A:M60	A:A:N371	2.8	No	Yes	0	9	9
850	B:B:C25	G:G:R27	2.79	No	No	0	3	8
851	B:B:F235	G:G:C41	2.79	Yes	No	0	6	7
852	R:R:C460	R:R:F227	2.79	No	No	0	9	9
853	A:A:A337	A:A:F315	2.77	No	Yes	0	8	6
854	B:B:D27	G:G:K29	2.77	No	No	0	8	4
855	B:B:A104	B:B:F151	2.77	No	Yes	0	7	9
856	B:B:A113	B:B:F151	2.77	No	Yes	0	9	9
857	B:B:A208	B:B:F222	2.77	No	Yes	10	6	8
858	B:B:A208	B:B:F241	2.77	No	Yes	10	6	6
859	B:B:A299	B:B:F278	2.77	No	Yes	0	5	7
860	B:B:A309	R:R:R476	2.77	No	No	0	3	7
861	A:A:K216	A:A:Q213	2.71	No	No	0	4	3
862	A:A:D295	A:A:L296	2.71	No	Yes	0	9	6
863	B:B:D66	B:B:L69	2.71	No	No	0	8	5
864	G:G:E17	G:G:M21	2.71	No	No	0	6	1
865	G:G:D48	G:G:L51	2.71	Yes	No	0	9	6
866	R:R:E391	R:R:K388	2.7	No	Yes	0	7	9
867	A:A:A372	A:A:Y63	2.67	No	No	0	8	9
868	R:R:A234	R:R:Y195	2.67	No	Yes	0	8	7
869	B:B:D312	B:B:D333	2.66	No	Yes	0	5	9
870	A:A:H41	A:A:I383	2.65	No	No	0	6	8
871	A:A:H387	A:A:I383	2.65	No	No	0	8	8
872	B:B:E172	B:B:N155	2.63	No	No	0	6	3
873	B:B:F199	B:B:V213	2.62	Yes	No	0	9	4
874	R:R:F461	R:R:V204	2.62	No	No	0	8	5
875	R:R:R390	R:R:T387	2.59	No	No	0	6	7
876	B:B:H266	B:B:N268	2.55	Yes	No	0	4	4
877	R:R:S316	R:R:Y320	2.54	No	No	0	7	4
878	R:R:V412	R:R:Y459	2.52	No	No	0	8	8
879	A:A:F246	A:A:I276	2.51	No	No	0	9	8
880	B:B:I123	B:B:R137	2.51	Yes	No	0	6	5
881	R:R:F212	R:R:I208	2.51	Yes	No	0	7	8
882	A:A:T325	A:A:Y339	2.5	No	Yes	0	2	3
883	R:R:F212	R:R:L215	2.44	Yes	No	0	7	9
884	B:B:I123	B:B:Y111	2.42	Yes	No	0	6	4
885	B:B:F292	B:B:N313	2.42	No	No	0	4	7
886	R:R:K360	R:R:Y429	2.39	No	No	0	7	6
887	B:B:Q259	B:B:R22	2.34	No	No	0	6	6
888	R:R:Q401	R:R:R400	2.34	No	No	0	6	8
889	B:B:G115	B:B:G116	2.11	No	No	0	9	9
890	R:R:G277	R:R:G350	2.11	No	No	0	4	5
891	B:B:C317	B:B:G330	1.96	No	No	0	7	5
892	A:A:A226	A:A:G206	1.95	No	Yes	0	9	8
893	B:B:A305	B:B:G306	1.95	No	No	0	4	4
894	R:R:A333	R:R:G330	1.95	No	No	0	5	7
895	B:B:A106	B:B:P107	1.87	No	No	0	6	6
896	R:R:W474	R:R:W477	1.87	No	No	0	5	4
897	A:A:G206	A:A:S205	1.86	Yes	No	0	8	7
898	B:B:G288	B:B:S275	1.86	No	No	0	7	8
899	B:B:G41	B:B:V40	1.84	No	No	0	1	3
900	R:R:G194	R:R:V193	1.84	No	No	0	9	6
901	R:R:G280	R:R:V283	1.84	No	No	0	4	4
902	B:B:G131	B:B:T128	1.82	No	No	0	4	3
903	B:B:G224	B:B:T223	1.82	No	No	0	6	2
904	R:R:G350	R:R:T349	1.82	No	No	0	5	5
905	B:B:A60	B:B:C103	1.81	No	No	0	7	8
906	B:B:P107	B:B:T65	1.75	No	No	0	6	1
907	G:G:P53	G:G:T52	1.75	No	No	0	8	4
908	A:A:G304	A:A:K305	1.74	No	No	0	5	3
909	A:A:L30	B:B:G53	1.71	No	No	0	5	9
910	B:B:C103	B:B:V71	1.71	No	Yes	0	8	8
911	R:R:G303	R:R:L377	1.71	No	No	0	9	7
912	A:A:A298	A:A:V334	1.7	No	Yes	0	4	4
913	B:B:A11	G:G:V16	1.7	No	No	0	5	7
914	B:B:A309	B:B:V307	1.7	No	No	0	3	3
915	R:R:A284	R:R:V239	1.7	No	No	0	6	5
916	R:R:A242	R:R:V243	1.7	No	No	0	4	5
917	R:R:G357	R:R:N358	1.7	No	No	0	6	4
918	R:R:G464	R:R:N463	1.7	No	Yes	0	7	9
919	R:R:C217	R:R:T218	1.69	No	Yes	0	8	7
920	R:R:A347	R:R:T349	1.68	No	No	0	7	5
921	B:B:K301	B:B:P39	1.67	No	No	0	5	1
922	A:A:I383	R:R:A313	1.62	No	No	0	8	7
923	B:B:I33	G:G:A34	1.62	No	No	0	3	6
924	B:B:A140	B:B:I120	1.62	No	No	0	5	6
925	B:B:A248	B:B:I269	1.62	No	No	0	5	4
926	R:R:S196	R:R:V193	1.62	No	No	0	7	6
927	A:A:A372	A:A:M60	1.61	No	No	0	8	9
928	A:A:D331	A:A:P332	1.61	Yes	No	0	4	1
929	B:B:D38	B:B:P39	1.61	No	No	0	1	1
930	R:R:A210	R:R:M224	1.61	No	No	0	4	5
931	R:R:A284	R:R:K240	1.61	No	No	0	6	7
932	B:B:S207	B:B:T223	1.6	No	No	0	5	2
933	R:R:S341	R:R:T345	1.6	No	No	0	5	3
934	R:R:S475	R:R:T478	1.6	No	No	0	4	4
935	B:B:A11	G:G:L19	1.58	No	Yes	0	5	9
936	B:B:L30	G:G:A34	1.58	No	No	0	5	6
937	G:G:A45	G:G:L51	1.58	No	No	0	4	6
938	R:R:A386	R:R:L406	1.58	No	No	0	6	8
939	A:A:A19	B:B:N88	1.56	No	Yes	0	4	7
940	A:A:I276	A:A:S275	1.55	No	No	0	8	8
941	R:R:I190	R:R:V193	1.54	No	No	0	6	6
942	R:R:I362	R:R:V338	1.54	No	No	0	8	5
943	B:B:M262	B:B:S31	1.53	Yes	No	0	4	1
944	R:R:K405	R:R:S409	1.53	No	No	0	8	9
945	A:A:M221	A:A:V57	1.52	No	No	0	8	7
946	A:A:I285	A:A:T284	1.52	No	No	0	7	4
947	B:B:A28	B:B:Q32	1.52	No	No	0	4	1
948	A:A:A316	A:A:E309	1.51	No	No	0	2	4
949	G:G:A39	G:G:E42	1.51	No	No	0	3	1
950	A:A:L393	R:R:S409	1.5	Yes	No	5	8	9
951	R:R:L385	R:R:S409	1.5	Yes	No	5	8	9
952	R:R:L446	R:R:S449	1.5	No	No	0	5	9
953	R:R:L416	R:R:V419	1.49	Yes	No	0	9	7
954	A:A:V20	B:B:N88	1.48	No	Yes	0	3	7
955	B:B:I123	B:B:I171	1.47	Yes	No	0	6	6
956	B:B:I157	B:B:I171	1.47	No	No	0	7	6
957	R:R:I371	R:R:I422	1.47	Yes	No	0	7	5
958	R:R:L389	R:R:T392	1.47	No	No	0	8	7
959	B:B:A206	B:B:H225	1.46	No	Yes	0	4	9
960	B:B:L14	G:G:K20	1.41	No	No	0	8	6
961	R:R:G323	R:R:W322	1.41	No	No	0	1	3
962	B:B:H54	B:B:S334	1.39	Yes	No	0	9	4
963	R:R:A242	R:R:F238	1.39	No	No	0	4	7
964	A:A:K32	A:A:Q29	1.36	No	No	0	4	4
965	R:R:D241	R:R:L244	1.36	No	No	0	8	5
966	R:R:E444	R:R:M441	1.35	No	No	0	7	6
967	A:A:E299	A:A:L296	1.33	No	Yes	0	6	6
968	B:B:L14	B:B:Q17	1.33	No	No	0	8	4
969	R:R:R476	R:R:S475	1.32	No	No	0	7	4
970	R:R:F287	R:R:V283	1.31	No	No	0	3	4
971	A:A:Q390	R:R:E465	1.27	No	No	0	4	9
972	B:B:D267	B:B:H266	1.26	No	Yes	0	3	4
973	A:A:K58	A:A:R61	1.24	No	No	0	9	8
974	B:B:D212	B:B:R214	1.19	No	No	0	9	9
975	B:B:D303	B:B:R304	1.19	No	Yes	0	2	5
976	A:A:E314	A:A:R317	1.16	Yes	No	0	6	2
977	B:B:E12	B:B:R8	1.16	No	No	0	4	3
978	R:R:K318	R:R:W322	1.16	No	No	0	5	3
979	R:R:Q438	R:R:W437	1.1	No	No	0	4	5
980	R:R:R400	R:R:Y403	1.03	No	No	0	8	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	A:A:N50	6.6675	4	0	9
2	A:A:K53	5.85	4	23	9
3	A:A:G206	2.6225	4	0	8
4	A:A:F219	7.732	5	0	8
5	A:A:F222	10.845	4	1	7
6	A:A:K233	6.09333	6	1	9
7	A:A:W234	6.6975	4	0	9
8	A:A:F238	8.954	5	1	9
9	A:A:D249	9.6475	4	0	8
10	A:A:Y253	7.23	5	0	8
11	A:A:F273	5.874	5	6	9
12	A:A:W277	9.246	5	6	6
13	A:A:L282	5.2275	4	22	9
14	A:A:L289	4.894	5	6	9
15	A:A:F290	6.642	5	16	9
16	A:A:Q294	5.854	5	6	6
17	A:A:L296	3.9225	4	0	6
18	A:A:I308	8.3475	4	13	7
19	A:A:F312	6.1125	4	13	8
20	A:A:E314	5.392	5	13	6
21	A:A:F315	12.094	5	13	6
22	A:A:Y318	9.765	4	0	6
23	A:A:E330	6.1075	4	6	3
24	A:A:D331	6.5875	4	0	4
25	A:A:V334	4.8875	4	0	4
26	A:A:K338	7.7775	4	6	5
27	A:A:Y339	6.456	5	0	3
28	A:A:F340	10.4	6	13	7
29	A:A:F345	8.7	4	6	8
30	A:A:F363	7.3525	4	6	5
31	A:A:T364	6.932	5	16	9
32	A:A:D368	6.8875	4	16	9
33	A:A:N371	7.37	5	16	9
34	A:A:F376	6.114	5	19	8
35	A:A:R385	8.855	4	17	5
36	A:A:Y391	7.72	6	5	4
37	A:A:L393	3.494	5	5	8
38	B:B:H54	7.58167	6	11	9
39	B:B:K57	13.3175	4	2	9
40	B:B:W63	6.94	5	0	7
41	B:B:V71	4.325	4	7	8
42	B:B:D76	6.68	5	21	9
43	B:B:L79	5.4125	4	7	7
44	B:B:I80	8.3075	4	11	8
45	B:B:W82	9.55833	6	11	9
46	B:B:N88	5.555	4	0	7
47	B:B:K89	6.72	5	11	9
48	B:B:H91	5.5525	4	0	5
49	B:B:I93	6.6375	4	7	7
50	B:B:L95	4.874	5	7	8
51	B:B:W99	9.68333	6	1	9
52	B:B:M101	7.775	4	0	9
53	B:B:Y105	4.72	5	7	6
54	B:B:V112	5.13	4	7	8
55	B:B:I123	2.756	5	0	6
56	B:B:Y124	5.15286	7	7	6
57	B:B:H142	8.4325	4	1	9
58	B:B:Y145	5.76286	7	1	8
59	B:B:F151	4.3425	4	0	9
60	B:B:L152	4.9025	4	3	3
61	B:B:T159	4.105	4	0	9
62	B:B:S160	5.2425	4	3	6
63	B:B:D163	8.926	5	1	9
64	B:B:W169	10.595	4	24	8
65	B:B:Q176	7.0175	4	24	4
66	B:B:F180	8.102	5	3	7
67	B:B:H183	8.72	4	3	9
68	B:B:V187	5.412	5	3	9
69	B:B:M188	5.3775	4	1	8
70	B:B:F199	6.6125	4	3	9
71	B:B:V200	8.5525	4	10	6
72	B:B:C204	5.79	4	1	7
73	B:B:D205	6.87	5	3	9
74	B:B:K209	7.91	4	3	6
75	B:B:L210	5.154	5	0	5
76	B:B:W211	7.805	6	3	8
77	B:B:F222	7.846	5	10	8
78	B:B:H225	9.42667	6	14	9
79	B:B:D228	8.485	4	1	9
80	B:B:F235	8.92428	7	9	6
81	B:B:N237	6.69167	6	9	5
82	B:B:F241	8.554	5	10	6
83	B:B:D247	5.64833	6	14	9
84	B:B:R251	9.502	5	14	8
85	B:B:F253	9.3075	4	10	6
86	B:B:R256	5.982	5	9	9
87	B:B:D258	7.9475	4	10	7
88	B:B:M262	5.1025	4	0	4
89	B:B:Y264	5.936	5	2	5
90	B:B:H266	3.075	4	0	4
91	B:B:F278	7.504	5	0	7
92	B:B:Y289	5.89714	7	2	7
93	B:B:D290	6.742	5	2	6
94	B:B:N295	7.5275	4	2	6
95	B:B:W297	7.455	4	2	8
96	B:B:R304	6.335	4	0	5
97	B:B:H311	9.102	5	4	9
98	B:B:R314	13.818	5	2	8
99	B:B:T321	6.7775	4	8	7
100	B:B:M325	4.9075	4	8	5
101	B:B:W332	12.846	5	2	9
102	B:B:D333	8.3975	4	4	9
103	B:B:K337	8.96	4	4	6
104	B:B:W339	8.58571	7	4	9
105	B:B:N340	4.52	4	8	9
106	G:G:I9	4.015	4	0	2
107	G:G:L19	5.14	4	0	9
108	G:G:E22	6.04	4	0	9
109	G:G:Y40	9.885	4	9	6
110	G:G:D48	5.08	6	4	9
111	G:G:P49	4.7825	4	0	7
112	G:G:P60	7.415	4	8	9
113	G:G:F61	5.3	8	8	8
114	R:R:Y195	8.9725	4	0	7
115	R:R:F212	5.7275	4	0	7
116	R:R:T218	6.5275	4	0	7
117	R:R:R219	7.984	5	5	9
118	R:R:H223	9.9025	4	5	9
119	R:R:F230	9.462	5	0	8
120	R:R:M231	4.01	4	0	8
121	R:R:R233	6.565	4	0	8
122	R:R:F288	6.1825	4	0	7
123	R:R:Y290	7.02	5	15	9
124	R:R:F291	9.685	4	0	5
125	R:R:L292	4.4725	4	12	6
126	R:R:T294	5.775	4	15	8
127	R:R:Y296	6.0825	4	12	7
128	R:R:Y297	8.14	5	18	6
129	R:R:W298	13.03	4	15	9
130	R:R:E302	9.6975	4	5	9
131	R:R:Y305	8.56	5	0	8
132	R:R:W329	11.125	4	15	9
133	R:R:W339	6.18333	6	20	8
134	R:R:W352	15.04	4	20	8
135	R:R:I371	4.2475	4	12	7
136	R:R:F378	6.3725	4	27	9
137	R:R:L385	3.924	5	5	8
138	R:R:K388	7.645	4	17	9
139	R:R:L416	4.6575	4	0	9
140	R:R:H420	8.925	4	5	8
141	R:R:Y421	6.93667	6	12	8
142	R:R:F424	8.702	5	5	7
143	R:R:F447	8.56	5	5	5
144	R:R:F450	4.9275	4	0	7
145	R:R:Q451	12.2925	4	5	9
146	R:R:F453	7.23	4	0	6
147	R:R:N463	7.6675	4	0	9
148	W:W:?1	10.5864	11	5	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	B:B:D76	B:B:K78	11.0067	4.15	Yes	No	0	9	8
2	B:B:D76	B:B:S74	12.2818	10.31	Yes	No	0	9	9
3	B:B:H54	B:B:S74	12.5388	12.55	Yes	No	0	9	9
4	B:B:H54	B:B:W82	13.2269	7.41	Yes	Yes	11	9	9
5	B:B:Q75	B:B:W99	52.0629	8.76	No	Yes	0	9	9
6	B:B:K57	B:B:Q75	97.2977	13.56	Yes	No	0	9	9
7	B:B:K57	B:B:W332	97.0623	24.37	Yes	Yes	2	9	9
8	B:B:S316	B:B:W332	91.7038	6.18	No	Yes	0	9	9
9	B:B:C317	B:B:S316	91.6393	3.44	No	No	0	7	9
10	B:B:C317	B:B:M61	91.513	4.86	No	No	0	7	6
11	B:B:M61	B:B:W63	91.5257	5.82	No	Yes	0	6	7
12	B:B:L70	B:B:W63	17.8146	9.11	No	Yes	0	5	7
13	B:B:L70	B:B:W82	16.7879	5.69	No	Yes	11	5	9
14	A:A:F219	A:A:H41	21.3207	9.05	Yes	No	0	8	6
15	A:A:H41	A:A:I383	21.3435	2.65	No	No	0	6	8
16	A:A:H387	A:A:I383	21.2558	2.65	No	No	0	8	8
17	A:A:H387	R:R:L309	21.2822	16.71	No	No	0	8	8
18	R:R:L309	R:R:Y305	21.3106	15.24	No	Yes	0	8	8
19	R:R:I222	R:R:Y305	20.0532	7.25	No	Yes	0	9	8
20	R:R:E302	R:R:I222	20.8135	13.66	Yes	No	0	9	9
21	A:A:Y391	R:R:R219	11.054	12.35	Yes	Yes	5	4	9
22	R:R:N220	R:R:R219	89.1721	4.82	No	Yes	0	9	9
23	R:R:L215	R:R:N220	90.1954	4.12	No	No	0	9	9
24	R:R:E469	R:R:L215	90.9317	6.63	No	No	0	9	9
25	R:R:E469	R:R:R214	91.265	8.14	No	No	0	9	7
26	B:B:D312	R:R:R214	91.4319	8.34	No	No	0	5	7
27	B:B:D312	B:B:D333	91.6168	2.66	No	Yes	0	5	9
28	B:B:D333	B:B:H311	91.3022	11.35	Yes	Yes	4	9	9
29	B:B:H311	B:B:T329	45.7831	8.21	Yes	No	0	9	8
30	B:B:T329	B:B:W339	45.7094	7.28	No	Yes	0	8	9
31	B:B:M45	B:B:W339	92.2036	5.82	No	Yes	4	4	9
32	B:B:M45	G:G:L50	92.7464	4.24	No	No	4	4	9
33	G:G:D48	G:G:L50	91.6957	4.07	Yes	No	4	9	9
34	G:G:D48	G:G:P49	92.8387	4.83	Yes	Yes	0	9	7
35	B:B:G324	G:G:P49	88.0609	4.06	No	Yes	0	9	7
36	B:B:G324	B:B:T321	88.0629	3.64	No	Yes	0	9	7
37	B:B:T321	B:B:W63	88.3479	9.7	Yes	Yes	0	7	7
38	R:R:E302	W:W:?1	10.7446	7.1	Yes	Yes	5	9	0
39	R:R:R219	W:W:?1	71.3252	3.25	Yes	Yes	5	9	0
40	B:B:H311	B:B:K337	45.7837	7.86	Yes	Yes	4	9	6
41	B:B:K337	B:B:W339	46.5279	6.96	Yes	Yes	4	6	9
42	A:A:F238	B:B:W99	28.1944	14.03	Yes	Yes	1	9	9
43	A:A:K53	A:A:S51	25.8207	4.59	Yes	No	0	9	9
44	A:A:N50	A:A:S51	26.0375	2.98	Yes	No	0	9	9
45	A:A:D249	A:A:N50	13.4554	12.12	Yes	Yes	0	8	9
46	A:A:D249	A:A:D252	13.9708	3.99	Yes	No	0	8	8
47	A:A:D252	A:A:N264	26.8355	6.73	No	No	0	8	9
48	A:A:N264	A:A:Y311	26.8301	11.63	No	No	0	9	6
49	A:A:Y253	A:A:Y311	26.6551	5.96	Yes	No	0	8	6
50	A:A:L297	A:A:Y253	26.3947	3.52	No	Yes	0	8	8
51	A:A:L297	A:A:Q294	26.3128	6.65	No	Yes	6	8	6
52	A:A:L291	A:A:Q294	25.5818	6.65	No	Yes	6	8	6
53	A:A:L289	A:A:L291	26.9595	4.15	Yes	No	6	9	8
54	A:A:F246	A:A:L289	27.4961	3.65	No	Yes	0	9	9
55	A:A:D272	A:A:F246	27.4858	4.78	No	No	0	8	9
56	A:A:D272	A:A:R231	27.486	9.53	No	No	0	8	9
57	A:A:R231	A:A:W234	27.2561	7	No	Yes	0	9	9
58	A:A:F238	A:A:W234	27.5827	4.01	Yes	Yes	0	9	9
59	A:A:N50	A:A:R265	12.8165	8.44	Yes	No	0	9	9
60	A:A:D252	A:A:R265	12.8852	5.96	No	No	0	8	9
61	A:A:K53	A:A:L45	25.448	5.64	Yes	No	23	9	8
62	A:A:L45	A:A:M221	25.4201	4.24	No	No	0	8	8
63	A:A:D378	A:A:Y360	17.5282	10.34	No	No	0	7	8
64	A:A:D381	A:A:Y360	18.2941	3.45	No	No	0	8	8
65	A:A:D381	R:R:K388	18.4914	12.44	No	Yes	17	8	9
66	A:A:Q384	R:R:K388	21.8469	6.78	No	Yes	0	6	9
67	A:A:Q384	A:A:R380	22.0993	3.5	No	No	0	6	7
68	A:A:F376	A:A:R380	22.3515	3.21	Yes	No	0	8	7
69	A:A:F219	A:A:F376	24.1121	6.43	Yes	Yes	0	8	8
70	A:A:D378	A:A:H362	10.9919	12.61	No	No	0	7	9
71	B:B:M101	B:B:Y145	45.4054	4.79	Yes	Yes	0	9	8
72	B:B:M101	B:B:Y59	45.5507	17.96	Yes	No	0	9	8
73	B:B:Q75	B:B:Y59	45.6214	3.38	No	No	0	9	8
74	B:B:L117	B:B:Y145	68.1168	3.52	No	Yes	1	9	8
75	B:B:L117	B:B:W99	67.6597	4.56	No	Yes	1	9	9
76	A:A:F212	A:A:F219	24.9917	9.65	No	Yes	0	9	8
77	A:A:K233	B:B:Y145	100	3.58	Yes	Yes	1	9	8
78	A:A:K233	B:B:D228	49.7647	5.53	Yes	Yes	1	9	9
79	A:A:K233	B:B:D246	49.5623	5.53	Yes	No	1	9	9
80	B:B:R314	B:B:W332	20.6326	18.99	Yes	Yes	2	8	9
81	B:B:D290	B:B:R314	19.1122	13.1	Yes	Yes	2	6	8
82	B:B:D228	B:B:S227	49.5412	4.42	Yes	No	0	9	6
83	B:B:D247	B:B:S227	98.5634	4.42	Yes	No	0	9	6
84	B:B:D247	B:B:H225	48.2948	7.56	Yes	Yes	14	9	9
85	B:B:H225	B:B:I229	27.1936	5.3	Yes	No	14	9	7
86	B:B:G202	B:B:I229	53.4474	3.53	No	No	0	6	7
87	B:B:G202	B:B:S201	52.6544	3.71	No	No	0	6	9
88	B:B:S201	B:B:W211	38.2519	4.94	No	Yes	0	9	8
89	B:B:K209	B:B:W211	10.429	5.8	Yes	Yes	3	6	8
90	G:G:E22	G:G:L19	23.9908	10.6	Yes	Yes	0	9	9
91	B:B:D246	B:B:S227	49.406	5.89	No	No	0	9	6
92	B:B:D247	B:B:S245	27.446	7.36	Yes	No	14	9	9
93	B:B:I229	B:B:S245	27.0508	4.64	No	No	14	7	9
94	B:B:C218	B:B:W211	10.4303	5.22	No	Yes	3	5	8
95	B:B:H225	B:B:T243	20.5643	6.85	Yes	No	0	9	8
96	B:B:F253	B:B:T243	20.16	9.08	Yes	No	0	6	8
97	B:B:F222	B:B:F253	25.6566	15	Yes	Yes	10	8	6
98	B:B:D258	B:B:F222	17.613	4.78	Yes	Yes	10	7	8
99	B:B:D258	B:B:R22	14.5088	11.91	Yes	No	0	7	6
100	B:B:I18	B:B:R22	10.5458	6.26	No	No	0	7	6
101	B:B:D247	B:B:R251	21.2627	3.57	Yes	Yes	14	9	8
102	B:B:E260	B:B:R251	20.4786	6.98	No	Yes	0	6	8
103	B:B:E260	B:B:F253	20.0709	3.5	No	Yes	0	6	6
104	B:B:L14	G:G:L19	11.9976	4.15	No	Yes	0	8	9
105	B:B:C271	B:B:D290	18.7342	6.22	No	Yes	2	5	6
106	B:B:C271	B:B:Y289	16.3164	4.03	No	Yes	2	5	7
107	B:B:W297	B:B:Y289	11.1015	9.65	Yes	Yes	2	8	7
108	B:B:G162	B:B:Y145	11.6136	4.35	No	Yes	1	9	8
109	B:B:G162	B:B:S161	11.4027	3.71	No	No	1	9	9
110	B:B:S201	B:B:V187	13.6487	3.23	No	Yes	0	9	9
111	B:B:F241	B:B:F253	13.7676	9.65	Yes	Yes	10	6	6
112	B:B:F241	B:B:V200	10.5444	14.42	Yes	Yes	10	6	6
113	R:R:L416	W:W:?1	12.204	5.19	Yes	Yes	0	9	0
114	R:R:E444	R:R:F424	16.6691	24.49	No	Yes	0	7	7
115	R:R:F417	W:W:?1	44.74	19.56	No	Yes	5	9	0
116	R:R:E444	R:R:M445	11.2766	4.06	No	No	0	7	6
117	R:R:M445	R:R:Y191	10.684	8.38	No	No	0	6	7
118	R:R:Y191	R:R:Y195	10.1001	14.89	No	Yes	0	7	7
119	R:R:F417	R:R:Q451	35.0259	22.25	No	Yes	5	9	9
120	R:R:Q451	R:R:R233	26.1639	9.35	Yes	Yes	0	9	8
121	R:R:L292	R:R:R233	20.5209	4.86	Yes	Yes	0	6	8
122	R:R:F288	R:R:L292	14.1137	3.65	Yes	Yes	0	7	6
123	R:R:S449	R:R:Y195	13.4811	3.82	No	Yes	0	9	7
124	R:R:F450	R:R:S449	11.686	6.61	Yes	No	0	7	9
125	R:R:Y459	W:W:?1	11.9062	25.74	No	Yes	0	8	0
126	R:R:F230	R:R:N295	11.4316	22.96	Yes	No	0	8	8
127	R:R:N295	R:R:S229	16.2402	7.45	No	No	0	8	9
128	R:R:S229	R:R:T294	15.4657	4.8	No	Yes	0	9	8
129	A:A:F212	A:A:M221	25.0211	4.98	No	No	0	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
A:A:L393	A:A:Y391	3.52	5	Yes	Yes	8	4	2	1
A:A:Y391	R:R:R219	12.35	5	Yes	Yes	4	9	1	1
A:A:Y391	R:R:H223	3.27	5	Yes	Yes	4	9	1	1
A:A:Y391	R:R:E302	4.49	5	Yes	Yes	4	9	1	1
A:A:Y391	R:R:L306	16.41	5	Yes	No	4	9	1	2
A:A:Y391	W:W:?1	6.28	5	Yes	Yes	4	0	1	0
A:A:E392	W:W:?1	4.97	0	No	Yes	6	0	1	0
R:R:N220	R:R:R219	4.82	0	No	Yes	9	9	2	1
R:R:H223	R:R:R219	9.03	5	Yes	Yes	9	9	1	1
R:R:E465	R:R:R219	10.47	0	No	Yes	9	9	2	1
R:R:R219	W:W:?1	3.25	5	Yes	Yes	9	0	1	0
R:R:E302	R:R:I222	13.66	5	Yes	No	9	9	1	2
R:R:E302	R:R:H223	13.54	5	Yes	Yes	9	9	1	1
R:R:H223	W:W:?1	13.77	5	Yes	Yes	9	0	1	0
R:R:I299	R:R:N374	4.25	0	No	No	9	9	1	2
R:R:I299	W:W:?1	6.88	0	No	Yes	9	0	1	0
R:R:E302	W:W:?1	7.1	5	Yes	Yes	9	0	1	0
R:R:L416	R:R:M414	4.24	0	Yes	No	9	8	1	2
R:R:H420	R:R:L416	7.71	5	Yes	Yes	8	9	2	1
R:R:L416	W:W:?1	5.19	0	Yes	Yes	9	0	1	0
R:R:F417	R:R:F447	7.5	5	No	Yes	9	5	1	2
R:R:F417	R:R:Q451	22.25	5	No	Yes	9	9	1	2
R:R:F417	W:W:?1	19.56	5	No	Yes	9	0	1	0
R:R:F447	R:R:H420	15.84	5	Yes	Yes	5	8	2	2
R:R:F447	R:R:Q451	8.2	5	Yes	Yes	5	9	2	2
R:R:V455	R:R:Y459	5.05	0	No	No	9	8	2	1
R:R:I458	W:W:?1	4.59	0	No	Yes	8	0	1	0
R:R:Y459	W:W:?1	25.74	0	No	Yes	8	0	1	0
R:R:E465	R:R:N463	3.94	0	No	Yes	9	9	2	1
R:R:N463	R:R:V466	5.91	0	Yes	No	9	9	1	2
R:R:N463	W:W:?1	19.12	0	Yes	Yes	9	0	1	0
R:R:V412	R:R:Y459	2.52	0	No	No	8	8	2	1
R:R:G464	R:R:N463	1.7	0	No	Yes	7	9	2	1
R:R:L416	R:R:V419	1.49	0	Yes	No	9	7	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
76.92	Single	8GW8	KHF	8GW8-PTH1-KHF-Gs/&β;1/&γ;2
27.78	Single	8FN0	PubChem 118610427	8FN0-NTS₁-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
26.67	Single	5T1A	PubChem 68764898; PubChem 12093170	5T1A-CCR2-PubChem 68764898; PubChem 12093170
26.32	Single	8JPB	PubChem 118610427; GDP; Mg	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
25.00	Consensus	nts1_on_allo	Other Ligand	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
23.08	Consensus	ccr2_off_allo	Other Ligand	5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
22.22	Single	8JPF	PubChem 118610427	8JPF-NTS₁-Neurotensin-PubChem 118610427
21.05	Single	8JPC	PubChem 118610427; GDP; Mg	8JPC-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
19.05	Single	5LWE	Vercirnon	5LWE-CCR9-Vercirnon
19.05	Consensus	ccr9_off_allo	Other Ligand	5LWE-CCR9-Vercirnon
15.79	Single	5XEZ	NNC0640	5XEZ-Glucagon-NNC0640
15.79	Single	6QZH	HY-133073; Na	6QZH-CCR7-HY-133073; Na
15.79	Consensus	ccr7_off_allo	Other Ligand	6QZH-CCR7-HY-133073; Na
15.00	Single	5XF1	NNC0640	5XF1-Glucagon-NNC0640
15.00	Single	6LFL	PubChem 153466996	6LFL-CXCR2-PubChem 153466996
15.00	Consensus	ffa3_on_allo	Other Ligand	8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
14.29	Single	8J20	AR420626	8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
11.11	Single	4K5Y	CP-376395	4K5Y-CRF₁-CP-376395
11.11	Single	6KK1	PubChem 68178630	6KK1-GLP-1-PubChem 68178630
10.53	Single	5VEW	PF-06372222	5VEW-GLP-1-PF-06372222
10.53	Single	5X7D	PubChem 129318963	5X7D-β₂-(S)-Carazolol-PubChem 129318963
10.00	Single	4Z9G	CP-376395	4Z9G-CRF₁-CP-376395
10.00	Single	8GTI	BMK-C205	8GTI-CRF₁-BMK-C205
9.52	Single	8GTG	BMK-I152	8GTG-CRF₁-BMK-I152
9.09	Single	6LN2	PubChem 68178630	6LN2-GLP-1-PubChem 68178630
8.70	Single	8GTM	BMK-C203	8GTM-CRF₁-BMK-C203
8.70	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
8.70	Single	8TB7	PubChem 168510218	8TB7-GPR61-PubChem 168510218
8.33	Single	8JD3	HZR; PEF	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
8.00	Single	6XBJ	Cholesterol	6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
7.69	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
7.41	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
7.14	Single	4PXF	Octyl Beta-D-Glucopyranoside	4PXF-Rhodopsin-Octyl Beta-D-Glucopyranoside-Arrestin1_Finger_loop
7.14	Single	6UO8	GS39783	6UO8-GABA_B1, GABA_B2-SKF97541-GS39783
5.88	Consensus	gip_on_allo	Other Ligand	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
5.56	Single	5VEX	NNC0640	5VEX-GLP-1-NNC0640
5.56	Single	6KK7	PubChem 68178630	6KK7-GLP-1-PubChem 68178630
5.56	Single	7CA3	rac-BHFF	7CA3-GABA_B1, GABA_B2-rac-BHFF
5.26	Single	6KJV	PubChem 68178630	6KJV-GLP-1-PubChem 68178630
5.26	Single	7C7Q	PubChem 7023848	7C7Q-GABA_B1, GABA_B2-Baclofen-PubChem 7023848
5.26	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
5.26	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
5.26	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.26	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.26	Single	8A6C	All-trans-retinal	8A6C-Rhodopsin-All-trans-retinal
5.26	Single	8A6D	All-trans-retinal	8A6D-Rhodopsin-All-trans-retinal
5.26	Single	8A6E	All-trans-retinal	8A6E-Rhodopsin-All-trans-retinal
5.26	Single	8HNN	SCH546738	8HNN-CXCR3-SCH546738
5.26	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
5.26	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.00	Single	3OAX	11-cis-Retinal	3OAX-Rhodopsin-11-cis-Retinal
5.00	Single	6A94	Zotepine	6A94-5-HT_2A-Zotepine
5.00	Single	7VOD	Cariprazine	7VOD-5-HT_2A-Cariprazine
5.00	Single	7ZBC	11-cis-Retinal	7ZBC-Rhodopsin-11-cis-Retinal
5.00	Consensus	5ht2a_off	Orthosteric Ligand	6A94-5-HT_2A-Zotepine 6WH4-5-HT_2A-Methiothepin 7VOE-5-HT_2A-Aripiprazole 7VOD-5-HT_2A-Cariprazine 7WC8-5-HT_2A-Lumateperone 6A93-5-HT_2A-Risperidone
4.76	Single	1HZX	11-cis-Retinal	1HZX-Rhodopsin-11-cis-Retinal
4.76	Single	6FKD	PubChem 137349183	6FKD-Rhodopsin-PubChem 137349183
4.76	Single	7F83	PF-05190457	7F83-Ghrelin-PF-05190457
4.76	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
4.76	Single	7WC8	Lumateperone	7WC8-5-HT_2A-Lumateperone
4.76	Single	8JT8	(R)-IHCH-7179	8JT8-5-HT_2A-(R)-IHCH-7179
4.76	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
4.55	Single	6LUQ	Haloperidol	6LUQ-D₂-Haloperidol
4.55	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
4.55	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
4.55	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
4.55	Single	7VOE	Aripiprazole	7VOE-5-HT_2A-Aripiprazole
4.55	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
4.35	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
4.35	Single	8JD0	J9R	8JD0-mGlu2; mGlu3-Glutamate-J9R
4.35	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.35	Single	8TAO	CDPPB	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.35	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17	Single	6A93	Risperidone	6A93-5-HT_2A-Risperidone
4.17	Single	6CM4	Risperidone	6CM4-D₂-Risperidone
4.17	Single	6XBL	Cholesterol	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
4.17	Consensus	gi_class-f	Other Ligand	gi_frizzled
4.17	Consensus	gi_frizzled	Other Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
3.57	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
3.12	Single	3VG9	Antibody	3VG9-A_2A-ZM241385-Antibody
2.94	Single	3VGA	Antibody	3VGA-A_2A-ZM241385-Antibody
2.86	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
2.86	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/&β;1/&γ;2
2.86	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
2.70	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.70	Single	8F0K	Pramlintide analogue san385	8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.63	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.33	Single	8F2B	Pramlintide analogue san45	8F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.33	Consensus	gs_ct	Orthosteric Ligand	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.22	Single	8F0J	Pramlintide analogue san45	8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

PDB Summary
PDB	8JR9
Class	B1
SubFamily	Peptide
Type	Parathyroid hormone
SubType	PTH1
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	PCO371
Protein Partners	chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution	2.57
Date	2023-08-02
D.O.I.	10.1038/s41586-023-06467-w

Net Summary
I_min	3.13
Number of Linked Nodes	821
Number of Links	980
Number of Hubs	148
Number of Links mediated by Hubs	553
Number of Communities	28
Number of Nodes involved in Communities	222
Number of Links involved in Communities	308

Path Summary
Number Of Nodes in MetaPath	130
Number Of Links MetaPath	129
Number of Shortest Paths	1872840
Length Of Smallest Path	3
Average Path Length	34.8591
Length of Longest Path	57
Minimum Path Strength	1.285
Average Path Strength	7.10076
Maximum Path Strength	24.49
Minimum Path Correlation	0.7
Average Path Correlation	0.980354
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.17391
Average % Of Corr. Nodes	37.8694
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.538
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	KHF
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	KHF
Name	PCO-371
Synonyms	1-[3,5-dimethyl-4-[2-[[4-oxidanylidene-2-[4-(trifluoromethyloxy)phenyl]-1,3,8-triazaspiro[4.5]dec-1-en-8-yl]sulfonyl]ethyl]phenyl]-5,5-dimethyl-imidazolidine-2,4-dione
Identifier	1-[3,5-dimethyl-4-[2-[[4-oxidanylidene-2-[4-(trifluoromethyloxy)phenyl]-1,3,8-triazaspiro[4.5]dec-1-en-8-yl]sulfonyl]ethyl]phenyl]-5,5-dimethyl-imidazolidine-2,4-dione
Formula	C29 H32 F3 N5 O6 S
Molecular Weight	635.654
SMILES	Cc1cc(cc(c1CCS(=O)(=O)N2CCC3(CC2)C(=O)NC(=N3)c4ccc(cc4)OC(F)(F)F)C)N5C(=O)NC(=O)C5(C)C
PubChem	76283707
Formal Charge	0
Total Atoms	76
Total Chiral Atoms	0
Total Bonds	80
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	A
Protein	G Protein α Sub unit
UniProt	P63092
Sequence	>8JR9_Chain_A L S A E D K A A V E R S K M I E K Q L Q K D K Q V Y R A T H R L L L L G A D N S G K S T I V K Q M R I Y H V T S G I F E T K F Q V D K V N F H M F D V G A Q R D E R R K W I Q C F N D V T A I I F V V D S S D Y N R L Q E A L N D F K S I W N N R W L R T I S V I L F L N K Q D L L A E K V L A G K S K I E D Y F P E F A R Y T T P E D A T P E E D P R V T R A K Y F I R D E F L R I S T A S G D G R H Y C Y P H F T C S V D T E N A R R I F N D C R D I I Q R M H L R Q Y E L L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	B
Protein	G Protein β Sub unit
UniProt	P62873
Sequence	>8JR9_Chain_B E L D Q L R Q E A E Q L K N Q I R D A R K A C A D A T L S Q I T N N I D P V G R I Q M R T R R T L R G H L A K I Y A M H W G T D S R L L V S A S Q D G K L I I W D S Y T T N K V H A I P L R S S W V M T C A Y A P S G N Y V A C G G L D N I C S I Y N L K T R E G N V R V S R E L A G H T G Y L S C C R F L D D N Q I V T S S G D T T C A L W D I E T G Q Q T T T F T G H T G D V M S L S L A P D T R L F V S G A C D A S A K L W D V R E G M C R Q T F T G H E S D I N A I C F F P N G N A F A T G S D D A T C R L F D L R A D Q E L M T Y S H D N I I C G I T S V S F S K S G R L L L A G Y D D F N C N V W D A L K A D R A G V L A G H D N R V S C L G V T D D G M A V A T G S W D S F L K I W N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	G
Protein	G Protein γ Sub unit
UniProt	P59768
Sequence	>8JR9_Chain_G A S I A Q A R K L V E Q L K M E A N I D R I K V S K A A A D L M A Y C E A H A K E D P L L T P V P A S E N P F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	Q03431
Sequence	>8JR9_Chain_R D R L A M I Y T V G Y S V S L A S L T V A V L I L A Y F R R L H C T R N Y I H M H L F L S F M L R A V S I F V K D A V L A G Y A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M A F F S E K K Y L W G F T V F G W G L P A V F V A V W V S V R A T L A N T G C W D L S S G N K K W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L R E T N T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M A T P Y L W Q V Q M H Y E M L F N S F Q G F F V A I I Y C F C N G E V Q A E I K K S W S R W T L A L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6FJ3	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	PTH	-	-	2.5	2018-11-21	10.1038/s41594-018-0151-4
	6NBF	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	Long-acting PTH analog	-	Gs/&β;1/&γ;2	3	2019-04-17	10.1126/science.aav7942
	6NBH	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	Long-acting PTH analog	-	Gs/&β;1/&γ;2	3.5	2019-04-17	10.1126/science.aav7942
	6NBI	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	Long-acting PTH analog	-	Gs/&β;1/&γ;2	4	2019-04-17	10.1126/science.aav7942
	7VVJ	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/&β;1/&γ;2	3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVK	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	PTH	-	Gs/&β;1/&γ;2	3.3	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVL	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	PTH	-	Gs/&β;1/&γ;2	2.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVM	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	PTH	-	Gs/&β;1/&γ;2	3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVN	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	PTH	-	Gs/&β;1/&γ;2	3.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVO	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	PTH	-	Gs/&β;1/&γ;2	4.1	2022-08-03	10.1016/j.molcel.2022.07.003
	7Y35	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/&β;1/&γ;2	2.9	2023-07-05	To be published
	7Y36	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	Teriparatide	-	Gs/&β;1/&γ;2	2.8	2023-07-05	To be published
	8FLQ	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	PTH	-	Gs/&β;1/&γ;2	2.55	2023-04-26	10.1016/j.str.2023.04.002
	8FLR	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/&β;1/&γ;2	2.94	2023-04-26	10.1016/j.str.2023.04.002
	8FLS	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/&β;1/&γ;2	3.09	2023-04-26	10.1016/j.str.2023.04.002
	8FLT	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	M-PTH(1-14)	-	Gs/&β;1/&γ;2	3.03	2023-04-26	10.1016/j.str.2023.04.002
	8FLU	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	Long-acting PTH	-	Gs/&β;1/&γ;2	2.76	2023-04-26	10.1016/j.str.2023.04.002
	8GW8	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	-	KHF	Gs/&β;1/&γ;2	2.9	2023-06-14	10.1038/s41586-023-06169-3
	8HA0	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/&β;1/&γ;2	2.62	2022-12-21	10.1038/s41401-022-01032-z
	8HAF	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	chim(NtGi1-Gs)/&β;1/&γ;2	3.25	2022-12-21	10.1038/s41401-022-01032-z
	8HAO	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/&β;1/&γ;2	3.76	2022-12-21	10.1038/s41401-022-01032-z
	8JR9	B1	Peptide	Parathyroid hormone	PTH1	Homo sapiens	-	PCO371	chim(NtGi1-Gs)/&β;1/&γ;2	2.57	2023-08-02	10.1038/s41586-023-06467-w

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