psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	A:A:R22	B:B:H91	4.51	No	Yes	0	5	5
2	A:A:S23	B:B:N88	8.94	No	Yes	0	7	7
3	A:A:S23	B:B:K89	4.59	No	Yes	0	7	9
4	A:A:K28	A:A:M25	4.32	No	No	0	4	4
5	A:A:I26	B:B:K89	7.27	No	Yes	0	9	9
6	A:A:I26	B:B:A92	3.25	No	No	0	9	6
7	A:A:E27	A:A:Q31	3.82	No	No	0	6	4
8	A:A:E27	B:B:K89	8.1	No	Yes	0	6	9
9	A:A:D33	A:A:Q29	9.14	No	No	0	5	4
10	A:A:K34	A:A:Q31	4.07	No	No	0	4	4
11	A:A:D33	B:B:K78	4.15	No	No	0	5	8
12	A:A:K34	B:B:L55	4.23	No	No	0	4	6
13	A:A:R42	A:A:Y37	21.61	No	No	0	9	4
14	A:A:Y37	B:B:L55	4.69	No	No	21	4	6
15	A:A:Y37	B:B:D76	3.45	No	Yes	21	4	9
16	A:A:N218	A:A:T40	5.85	No	No	0	4	7
17	A:A:H220	A:A:T40	4.11	No	No	0	7	7
18	A:A:F219	A:A:H41	9.05	Yes	No	0	8	6
19	A:A:H41	A:A:T242	5.48	No	No	0	6	8
20	A:A:L44	A:A:L46	5.54	No	No	0	9	8
21	A:A:F238	A:A:L44	18.27	Yes	No	0	9	9
22	A:A:I244	A:A:L44	5.71	No	No	0	8	9
23	A:A:K53	A:A:L45	5.64	Yes	No	23	9	8
24	A:A:L45	A:A:M221	4.24	No	No	0	8	8
25	A:A:D223	A:A:L45	8.14	No	No	23	9	8
26	A:A:L46	A:A:R231	3.64	No	No	0	8	9
27	A:A:G47	A:A:K53	3.49	No	Yes	0	9	9
28	A:A:A48	A:A:N50	3.13	No	Yes	0	8	9
29	A:A:D249	A:A:N50	12.12	Yes	Yes	0	8	9
30	A:A:N50	A:A:R265	8.44	Yes	No	0	9	9
31	A:A:K53	A:A:S51	4.59	Yes	No	0	9	9
32	A:A:S51	A:A:V247	4.85	No	No	0	9	7
33	A:A:G52	A:A:T55	3.64	No	No	0	9	9
34	A:A:D223	A:A:K53	9.68	No	Yes	23	9	9
35	A:A:S366	A:A:T55	3.2	No	No	0	9	9
36	A:A:R61	A:A:V57	5.23	No	No	0	8	7
37	A:A:Q59	A:A:T369	4.25	No	No	0	9	9
38	A:A:R61	A:A:T210	3.88	No	No	0	8	7
39	A:A:I62	A:A:Y63	6.04	No	No	0	9	9
40	A:A:Q213	A:A:V65	12.89	No	No	0	3	5
41	A:A:F208	A:A:S205	5.28	No	No	0	5	7
42	A:A:G206	A:A:Q227	3.29	Yes	No	0	8	9
43	A:A:G206	B:B:N119	3.39	Yes	No	0	8	9
44	A:A:F222	A:A:I207	6.28	Yes	No	1	7	9
45	A:A:I207	B:B:W99	3.52	No	Yes	1	9	9
46	A:A:I207	B:B:L117	4.28	No	No	1	9	9
47	A:A:F208	A:A:G225	4.52	No	No	0	5	9
48	A:A:E209	A:A:K211	10.8	No	No	1	9	4
49	A:A:E209	A:A:H220	4.92	No	No	1	9	7
50	A:A:E209	A:A:F222	12.83	No	Yes	1	9	7
51	A:A:H220	A:A:K211	23.58	No	No	1	7	4
52	A:A:F212	A:A:F219	9.65	No	Yes	0	9	8
53	A:A:F212	A:A:M221	4.98	No	No	0	9	8
54	A:A:N218	A:A:Q213	6.6	No	No	0	4	3
55	A:A:D215	A:A:V214	4.38	No	No	19	5	6
56	A:A:R373	A:A:V214	3.92	No	No	19	5	6
57	A:A:F376	A:A:V214	6.55	Yes	No	19	8	6
58	A:A:D215	A:A:R373	10.72	No	No	19	5	5
59	A:A:D215	A:A:F376	9.55	No	Yes	19	5	8
60	A:A:F219	A:A:V217	6.55	Yes	No	0	8	5
61	A:A:F219	A:A:F376	6.43	Yes	Yes	0	8	8
62	A:A:C379	A:A:F219	6.98	No	Yes	0	8	8
63	A:A:F222	A:A:F238	3.22	Yes	Yes	1	7	9
64	A:A:F222	B:B:W99	21.05	Yes	Yes	1	7	9
65	A:A:V224	A:A:W234	12.26	No	Yes	0	9	9
66	A:A:Q227	B:B:Y145	9.02	No	Yes	0	9	8
67	A:A:E230	A:A:R228	10.47	No	No	0	9	9
68	A:A:R228	B:B:T164	6.47	No	No	0	9	6
69	A:A:R228	B:B:D186	11.91	No	No	0	9	9
70	A:A:E230	A:A:R232	10.47	No	No	0	9	8
71	A:A:R231	A:A:W234	7	No	Yes	0	9	9
72	A:A:D272	A:A:R231	9.53	No	No	0	8	9
73	A:A:R232	B:B:C204	4.18	No	Yes	1	8	7
74	A:A:R232	B:B:D228	13.1	No	Yes	1	8	9
75	A:A:K233	B:B:Y145	3.58	Yes	Yes	1	9	8
76	A:A:K233	B:B:M188	10.08	Yes	Yes	1	9	8
77	A:A:K233	B:B:C204	4.85	Yes	Yes	1	9	7
78	A:A:K233	B:B:D228	5.53	Yes	Yes	1	9	9
79	A:A:K233	B:B:N230	6.99	Yes	No	1	9	9
80	A:A:K233	B:B:D246	5.53	Yes	No	1	9	9
81	A:A:I235	A:A:W234	3.52	No	Yes	0	9	9
82	A:A:F238	A:A:W234	4.01	Yes	Yes	0	9	9
83	A:A:Q236	A:A:W281	9.86	No	No	2	8	5
84	A:A:Q236	B:B:R314	5.84	No	Yes	2	8	8
85	A:A:C237	B:B:M101	4.86	No	Yes	0	8	9
86	A:A:F238	A:A:V241	5.24	Yes	No	0	9	9
87	A:A:F238	B:B:W99	14.03	Yes	Yes	1	9	9
88	A:A:D240	A:A:N239	5.39	No	No	2	6	8
89	A:A:N239	B:B:K57	11.19	No	Yes	2	8	9
90	A:A:N239	B:B:W332	9.04	No	Yes	2	8	9
91	A:A:D240	B:B:K57	4.15	No	Yes	2	6	9
92	A:A:C379	A:A:T242	3.38	No	No	0	8	8
93	A:A:A243	A:A:I288	3.25	No	No	0	8	9
94	A:A:I244	A:A:I285	5.89	No	No	22	8	7
95	A:A:D272	A:A:F246	4.78	No	No	0	8	9
96	A:A:F246	A:A:L289	3.65	No	Yes	0	9	9
97	A:A:A269	A:A:V248	3.39	No	No	0	9	7
98	A:A:F345	A:A:V248	9.18	Yes	No	0	8	7
99	A:A:D249	A:A:S251	5.89	Yes	No	0	8	9
100	A:A:D249	A:A:D252	3.99	Yes	No	0	8	8
101	A:A:D249	A:A:K293	16.59	Yes	No	0	8	9
102	A:A:Q294	A:A:S250	7.22	Yes	No	6	6	6
103	A:A:L297	A:A:S250	7.51	No	No	6	8	6
104	A:A:L296	A:A:S251	6.01	Yes	No	0	6	9
105	A:A:D252	A:A:N264	6.73	No	No	0	8	9
106	A:A:D252	A:A:R265	5.96	No	No	0	8	9
107	A:A:L297	A:A:Y253	3.52	No	Yes	0	8	8
108	A:A:K300	A:A:Y253	9.55	No	Yes	0	9	8
109	A:A:S306	A:A:Y253	3.82	No	Yes	0	7	8
110	A:A:I308	A:A:Y253	13.3	Yes	Yes	0	7	8
111	A:A:Y253	A:A:Y311	5.96	Yes	No	0	8	6
112	A:A:N264	A:A:Y311	11.63	No	No	0	9	6
113	A:A:E268	A:A:R265	10.47	No	No	0	9	9
114	A:A:F312	A:A:L266	6.09	Yes	No	0	8	8
115	A:A:I341	A:A:L266	5.71	No	No	0	8	8
116	A:A:L270	A:A:Q267	6.65	No	No	0	6	4
117	A:A:N271	A:A:Q267	6.6	No	No	0	5	4
118	A:A:F345	A:A:L270	7.31	Yes	No	0	8	6
119	A:A:I348	A:A:L270	5.71	No	No	0	4	6
120	A:A:F273	A:A:W277	5.01	Yes	Yes	6	9	6
121	A:A:F273	A:A:V287	6.55	Yes	No	6	9	6
122	A:A:F273	A:A:L289	3.65	Yes	Yes	6	9	9
123	A:A:F273	A:A:F345	8.57	Yes	Yes	6	9	8
124	A:A:C359	A:A:F273	5.59	No	Yes	0	5	9
125	A:A:K274	A:A:N278	6.99	No	No	0	5	8
126	A:A:I348	A:A:K274	11.63	No	No	0	4	5
127	A:A:V287	A:A:W277	4.9	No	Yes	6	6	6
128	A:A:S349	A:A:W277	9.88	No	Yes	0	7	6
129	A:A:G353	A:A:W277	4.22	No	Yes	0	4	6
130	A:A:H357	A:A:W277	22.22	No	Yes	0	7	6
131	A:A:N278	A:A:S352	4.47	No	No	0	8	5
132	A:A:L282	A:A:N279	12.36	Yes	No	0	9	8
133	A:A:R280	A:A:R283	13.86	No	No	0	5	3
134	A:A:W281	B:B:D290	6.7	No	Yes	2	5	6
135	A:A:W281	B:B:R314	25.99	No	Yes	2	5	8
136	A:A:R283	A:A:R356	7.46	No	No	0	3	2
137	A:A:I382	A:A:S286	9.29	No	No	0	6	8
138	A:A:F290	A:A:I288	3.77	Yes	No	0	9	9
139	A:A:D378	A:A:I288	12.59	No	No	0	7	9
140	A:A:L289	A:A:L291	4.15	Yes	No	6	9	8
141	A:A:F345	A:A:L289	9.74	Yes	Yes	6	8	9
142	A:A:L289	A:A:P361	3.28	Yes	No	0	9	5
143	A:A:F290	A:A:H362	6.79	Yes	No	0	9	9
144	A:A:F290	A:A:T364	10.38	Yes	Yes	16	9	9
145	A:A:F290	A:A:N371	7.25	Yes	Yes	16	9	9
146	A:A:F290	A:A:I375	5.02	Yes	No	0	9	9
147	A:A:L291	A:A:Q294	6.65	No	Yes	6	8	6
148	A:A:F363	A:A:L291	3.65	Yes	No	6	5	8
149	A:A:N292	A:A:T364	7.31	No	Yes	0	9	9
150	A:A:K293	A:A:L296	5.64	No	Yes	0	9	6
151	A:A:L297	A:A:Q294	6.65	No	Yes	6	8	6
152	A:A:K338	A:A:Q294	4.07	Yes	Yes	6	5	6
153	A:A:F363	A:A:Q294	4.68	Yes	Yes	6	5	6
154	A:A:R333	A:A:V301	3.92	No	No	0	5	7
155	A:A:V301	A:A:V334	4.81	No	Yes	0	7	4
156	A:A:D331	A:A:L302	4.07	Yes	No	0	4	2
157	A:A:A303	A:A:K305	3.21	No	No	0	5	3
158	A:A:E309	A:A:K307	14.85	No	No	0	4	6
159	A:A:D310	A:A:K307	12.44	No	No	0	3	6
160	A:A:F312	A:A:I308	3.77	Yes	Yes	13	8	7
161	A:A:F315	A:A:I308	11.3	Yes	Yes	13	6	7
162	A:A:F340	A:A:I308	5.02	Yes	Yes	13	7	7
163	A:A:E309	A:A:F315	4.66	No	Yes	0	4	6
164	A:A:D310	A:A:Y311	9.2	No	No	0	3	6
165	A:A:E314	A:A:F312	8.16	Yes	Yes	13	6	8
166	A:A:F312	A:A:F340	6.43	Yes	Yes	13	8	7
167	A:A:E314	A:A:P313	3.14	Yes	No	0	6	6
168	A:A:E314	A:A:F340	8.16	Yes	Yes	13	6	7
169	A:A:E314	A:A:E344	6.34	Yes	No	13	6	5
170	A:A:F315	A:A:R336	22.45	Yes	No	0	6	5
171	A:A:F315	A:A:F340	19.29	Yes	Yes	13	6	7
172	A:A:P321	A:A:Y318	6.95	No	Yes	0	5	6
173	A:A:R336	A:A:Y318	4.12	No	Yes	0	5	6
174	A:A:F340	A:A:Y318	16.5	Yes	Yes	0	7	6
175	A:A:D343	A:A:Y318	11.49	No	Yes	0	3	6
176	A:A:P321	A:A:T320	3.5	No	No	0	5	1
177	A:A:R336	A:A:T320	3.88	No	No	0	5	1
178	A:A:D323	A:A:P321	4.83	No	No	0	4	5
179	A:A:D323	A:A:R342	3.57	No	No	0	4	4
180	A:A:A324	A:A:Y339	9.34	No	Yes	0	3	3
181	A:A:P326	A:A:T335	10.49	No	No	0	1	4
182	A:A:E327	A:A:E330	6.34	No	Yes	6	4	3
183	A:A:E327	A:A:K338	5.4	No	Yes	6	4	5
184	A:A:E330	A:A:V334	4.28	Yes	Yes	0	3	4
185	A:A:E330	A:A:T335	7.06	Yes	No	0	3	4
186	A:A:E330	A:A:K338	6.75	Yes	Yes	6	3	5
187	A:A:D331	A:A:R333	11.91	Yes	No	0	4	5
188	A:A:D331	A:A:V334	8.76	Yes	Yes	0	4	4
189	A:A:T335	A:A:Y339	4.99	No	Yes	0	4	3
190	A:A:F363	A:A:K338	14.89	Yes	Yes	6	5	5
191	A:A:R342	A:A:Y339	9.26	No	Yes	0	4	3
192	A:A:F363	A:A:Y339	6.19	Yes	Yes	0	5	3
193	A:A:E344	A:A:F340	7	No	Yes	13	5	7
194	A:A:L346	A:A:R342	8.5	No	No	0	4	4
195	A:A:E344	A:A:R347	8.14	No	No	0	5	4
196	A:A:L346	A:A:P361	4.93	No	No	0	4	5
197	A:A:S349	A:A:T350	3.2	No	No	0	7	4
198	A:A:C359	A:A:S349	3.44	No	No	0	5	7
199	A:A:D354	A:A:R356	9.53	No	No	0	3	2
200	A:A:G355	A:A:Y358	4.35	No	No	0	2	4
201	A:A:H357	A:A:R356	3.39	No	No	0	7	2
202	A:A:R385	A:A:Y358	9.26	Yes	No	17	5	4
203	A:A:Y358	R:R:T392	4.99	No	No	17	4	7
204	A:A:D378	A:A:Y360	10.34	No	No	0	7	8
205	A:A:D381	A:A:Y360	3.45	No	No	0	8	8
206	A:A:I382	A:A:Y360	4.84	No	No	0	6	8
207	A:A:H362	A:A:R374	13.54	No	No	0	9	4
208	A:A:D378	A:A:H362	12.61	No	No	0	7	9
209	A:A:D368	A:A:T364	5.78	Yes	Yes	16	9	9
210	A:A:N371	A:A:T364	7.31	Yes	Yes	16	9	9
211	A:A:R374	A:A:T364	3.88	No	Yes	16	4	9
212	A:A:D368	A:A:E370	5.2	Yes	No	0	9	4
213	A:A:D368	A:A:N371	13.46	Yes	Yes	16	9	9
214	A:A:N371	A:A:R374	6.03	Yes	No	16	9	4
215	A:A:N377	A:A:R373	7.23	No	No	0	4	5
216	A:A:F376	A:A:N377	4.83	Yes	No	0	8	4
217	A:A:F376	A:A:R380	3.21	Yes	No	0	8	7
218	A:A:Q384	A:A:R380	3.5	No	No	0	6	7
219	A:A:D381	A:A:R385	7.15	No	Yes	17	8	5
220	A:A:D381	R:R:K388	12.44	No	Yes	17	8	9
221	A:A:Q384	R:R:K388	6.78	No	Yes	0	6	9
222	A:A:R385	R:R:K388	8.66	Yes	Yes	17	5	9
223	A:A:R385	R:R:T392	10.35	Yes	No	17	5	7
224	A:A:H387	R:R:L309	16.71	No	No	0	8	8
225	A:A:L388	A:A:L393	4.15	No	Yes	5	8	8
226	A:A:L388	R:R:I310	5.71	No	No	0	8	8
227	A:A:L388	R:R:L385	5.54	No	Yes	5	8	8
228	A:A:L394	A:A:R389	3.64	No	No	0	8	4
229	A:A:L393	A:A:Y391	3.52	Yes	Yes	5	8	4
230	A:A:Y391	R:R:R219	12.35	Yes	Yes	5	4	9
231	A:A:Y391	R:R:H223	3.27	Yes	Yes	5	4	9
232	A:A:Y391	R:R:E302	4.49	Yes	Yes	5	4	9
233	A:A:Y391	R:R:L306	16.41	Yes	No	0	4	9
234	A:A:Y391	W:W:?1	6.21	Yes	Yes	5	4	0
235	A:A:E392	W:W:?1	6.32	No	Yes	0	6	0
236	A:A:L393	R:R:L385	4.15	Yes	Yes	5	8	8
237	A:A:L393	R:R:L413	4.15	Yes	No	0	8	9
238	A:A:L394	R:R:L385	4.15	No	Yes	0	8	8
239	B:B:E3	G:G:I9	4.1	No	Yes	0	5	2
240	B:B:L4	G:G:S8	9.01	No	No	0	4	4
241	B:B:D5	B:B:R8	8.34	No	No	0	1	3
242	B:B:L7	G:G:A12	4.73	No	No	0	8	5
243	B:B:E10	G:G:V16	7.13	No	No	0	8	7
244	B:B:L14	G:G:L19	4.15	No	Yes	0	8	9
245	B:B:K15	G:G:L19	4.23	No	Yes	0	6	9
246	B:B:N16	B:B:R19	8.44	No	No	0	1	4
247	B:B:I18	B:B:R22	6.26	No	No	0	7	6
248	B:B:I18	G:G:E22	4.1	No	Yes	0	7	9
249	B:B:I18	G:G:A23	3.25	No	No	0	7	8
250	B:B:D20	B:B:K23	5.53	No	No	0	2	2
251	B:B:D258	B:B:R22	11.91	Yes	No	0	7	6
252	B:B:D27	G:G:S31	7.36	No	No	0	8	9
253	B:B:S31	B:B:T29	6.4	No	No	0	1	3
254	B:B:Q32	B:B:T29	7.09	No	No	0	1	3
255	B:B:L30	B:B:T34	5.9	No	No	0	5	5
256	B:B:L30	B:B:M262	8.48	No	Yes	0	5	4
257	B:B:L300	B:B:T34	7.37	No	No	0	6	5
258	B:B:I37	G:G:M38	4.37	No	No	0	2	4
259	B:B:D298	B:B:V40	8.76	No	No	0	9	3
260	B:B:Q44	B:B:R42	12.85	No	No	0	4	2
261	B:B:I43	B:B:L284	4.28	No	No	0	3	5
262	B:B:A305	B:B:I43	4.87	No	No	0	4	3
263	B:B:Q44	B:B:R46	11.68	No	No	0	4	5
264	B:B:L308	B:B:M45	5.65	No	No	4	7	4
265	B:B:M45	B:B:W339	5.82	No	Yes	4	4	9
266	B:B:M45	G:G:L50	4.24	No	No	4	4	9
267	B:B:R46	B:B:R48	4.26	No	No	0	5	7
268	B:B:K337	B:B:T47	12.01	Yes	No	4	6	3
269	B:B:T47	B:B:W339	8.49	No	Yes	4	3	9
270	B:B:N340	B:B:R48	6.03	Yes	No	0	9	7
271	B:B:R49	B:B:T87	5.17	No	No	0	7	5
272	B:B:R49	G:G:F61	4.28	No	Yes	0	7	8
273	B:B:R52	B:B:T50	6.47	No	No	0	7	3
274	B:B:K337	B:B:T50	9.01	Yes	No	0	6	3
275	B:B:L51	B:B:L70	4.15	No	No	11	9	5
276	B:B:L51	B:B:W82	15.94	No	Yes	11	9	9
277	B:B:L336	B:B:L51	8.3	No	No	0	7	9
278	B:B:F335	B:B:R52	9.62	No	No	4	4	7
279	B:B:R52	R:R:R213	8.53	No	No	4	7	8
280	B:B:H54	B:B:I58	6.63	Yes	No	0	9	9
281	B:B:H54	B:B:S72	5.58	Yes	No	11	9	9
282	B:B:H54	B:B:S74	12.55	Yes	No	0	9	9
283	B:B:H54	B:B:I80	11.93	Yes	Yes	11	9	8
284	B:B:H54	B:B:W82	7.41	Yes	Yes	11	9	9
285	B:B:D76	B:B:L55	10.86	Yes	No	21	9	6
286	B:B:A56	B:B:D76	4.63	No	Yes	0	7	9
287	B:B:K57	B:B:Q75	13.56	Yes	No	0	9	9
288	B:B:K57	B:B:W332	24.37	Yes	Yes	2	9	9
289	B:B:I58	B:B:L336	4.28	No	No	0	9	7
290	B:B:Q75	B:B:Y59	3.38	No	No	0	9	8
291	B:B:M101	B:B:Y59	13.17	Yes	No	0	9	8
292	B:B:M61	B:B:W63	5.82	No	Yes	0	6	7
293	B:B:C317	B:B:M61	4.86	No	No	0	7	6
294	B:B:G319	B:B:M61	3.49	No	No	0	5	6
295	B:B:H62	B:B:R150	14.67	No	No	0	6	6
296	B:B:L70	B:B:W63	9.11	No	Yes	0	5	7
297	B:B:S84	B:B:W63	6.18	No	Yes	0	5	7
298	B:B:T321	B:B:W63	9.7	Yes	Yes	0	7	7
299	B:B:A328	B:B:W63	3.89	No	Yes	0	5	7
300	B:B:G64	B:B:Y105	4.35	No	Yes	0	5	6
301	B:B:S67	B:B:T321	7.99	No	Yes	8	5	7
302	B:B:D322	B:B:S67	4.42	No	No	0	1	5
303	B:B:D323	B:B:S67	8.83	No	No	8	7	5
304	B:B:D83	B:B:R68	15.48	No	No	0	8	5
305	B:B:R68	B:B:Y85	24.69	No	No	0	5	4
306	B:B:L69	B:B:V90	4.47	No	No	0	5	5
307	B:B:L70	B:B:W82	5.69	No	Yes	11	5	9
308	B:B:L79	B:B:V71	4.47	Yes	Yes	7	7	8
309	B:B:V71	B:B:Y105	6.31	Yes	Yes	7	8	6
310	B:B:V112	B:B:V71	4.81	Yes	Yes	7	8	8
311	B:B:S72	B:B:W82	4.94	No	Yes	11	9	9
312	B:B:L336	B:B:S72	7.51	No	No	0	7	9
313	B:B:A73	B:B:C103	3.61	No	No	0	9	8
314	B:B:D76	B:B:S74	10.31	Yes	No	0	9	9
315	B:B:Q75	B:B:W99	8.76	No	Yes	0	9	9
316	B:B:D76	B:B:K78	4.15	Yes	No	0	9	8
317	B:B:G77	B:B:L95	5.13	No	Yes	0	8	8
318	B:B:K78	B:B:P94	3.35	No	No	0	8	5
319	B:B:I93	B:B:L79	8.56	Yes	Yes	7	7	7
320	B:B:L79	B:B:L95	4.15	Yes	Yes	7	7	8
321	B:B:L79	B:B:V112	4.47	Yes	Yes	7	7	8
322	B:B:I80	B:B:W82	14.09	Yes	Yes	11	8	9
323	B:B:I80	B:B:K89	4.36	Yes	Yes	11	8	9
324	B:B:H91	B:B:I81	6.63	Yes	No	0	5	7
325	B:B:I81	B:B:Y105	3.63	No	Yes	7	7	6
326	B:B:I81	B:B:L126	4.28	No	No	7	7	5
327	B:B:K89	B:B:W82	9.28	Yes	Yes	11	9	9
328	B:B:D83	B:B:T86	4.34	No	No	0	8	6
329	B:B:I338	B:B:S84	6.19	No	No	8	5	5
330	B:B:S84	G:G:F61	6.61	No	Yes	8	5	8
331	B:B:Y85	G:G:P60	12.52	No	Yes	8	4	9
332	B:B:Y85	G:G:F61	5.16	No	Yes	8	4	8
333	B:B:N88	B:B:T86	10.24	Yes	No	0	7	6
334	B:B:H91	B:B:V90	6.92	Yes	No	0	5	5
335	B:B:H91	B:B:V133	4.15	Yes	No	0	5	4
336	B:B:I93	B:B:P94	3.39	Yes	No	0	7	5
337	B:B:I93	B:B:Y124	8.46	Yes	Yes	7	7	6
338	B:B:I93	B:B:V133	6.14	Yes	No	7	7	4
339	B:B:L95	B:B:V100	4.47	Yes	No	7	8	9
340	B:B:C114	B:B:L95	4.76	No	Yes	7	8	8
341	B:B:L95	B:B:Y124	5.86	Yes	Yes	7	8	6
342	B:B:R96	B:B:V135	5.23	No	No	0	6	4
343	B:B:E138	B:B:R96	9.3	No	No	0	6	6
344	B:B:D118	B:B:S97	10.31	No	No	0	9	8
345	B:B:S98	B:B:W99	6.18	No	Yes	0	8	9
346	B:B:L117	B:B:W99	4.56	No	Yes	1	9	9
347	B:B:C114	B:B:V100	3.42	No	No	7	8	9
348	B:B:G116	B:B:M101	3.49	No	Yes	0	9	9
349	B:B:M101	B:B:Y145	4.79	Yes	Yes	0	9	8
350	B:B:C148	B:B:T102	3.38	No	No	0	6	8
351	B:B:C149	B:B:T102	6.76	No	No	0	8	8
352	B:B:G109	B:B:Y105	5.79	No	Yes	0	5	6
353	B:B:L126	B:B:Y105	3.52	No	Yes	7	5	6
354	B:B:A106	B:B:F151	5.55	No	Yes	0	6	9
355	B:B:N110	B:B:S108	10.43	No	No	0	4	6
356	B:B:D154	B:B:S108	8.83	No	No	0	6	6
357	B:B:K127	B:B:N110	18.19	No	No	0	4	4
358	B:B:N125	B:B:Y111	12.79	No	No	0	4	4
359	B:B:D154	B:B:Y111	6.9	No	No	0	6	4
360	B:B:V112	B:B:Y124	3.79	Yes	Yes	7	8	6
361	B:B:L126	B:B:V112	7.45	No	Yes	7	5	8
362	B:B:C114	B:B:Y124	4.03	No	Yes	7	8	6
363	B:B:L117	B:B:Y145	3.52	No	Yes	1	9	8
364	B:B:D118	B:B:I120	7	No	No	0	9	6
365	B:B:E138	B:B:I120	6.83	No	No	0	6	6
366	B:B:C121	B:B:L139	6.35	No	No	0	8	9
367	B:B:C121	B:B:L146	3.17	No	No	0	8	7
368	B:B:C121	B:B:C149	3.64	No	No	0	8	8
369	B:B:S122	B:B:Y124	5.09	No	Yes	0	8	6
370	B:B:E138	B:B:S122	4.31	No	No	0	6	8
371	B:B:I123	B:B:L139	4.28	Yes	No	0	6	9
372	B:B:V133	B:B:Y124	3.79	No	Yes	7	4	6
373	B:B:V135	B:B:Y124	5.05	No	Yes	0	4	6
374	B:B:N132	B:B:R134	4.82	No	No	0	3	3
375	B:B:G174	B:B:R137	6	No	No	0	4	5
376	B:B:L139	B:B:W169	20.5	No	Yes	0	9	8
377	B:B:G141	B:B:Q176	3.29	No	Yes	0	5	4
378	B:B:H142	B:B:T159	4.11	Yes	Yes	0	9	9
379	B:B:H142	B:B:S161	13.95	Yes	No	1	9	9
380	B:B:D163	B:B:H142	8.82	Yes	Yes	1	9	9
381	B:B:H142	B:B:T165	6.85	Yes	No	1	9	7
382	B:B:G144	B:B:T143	3.64	No	No	1	8	5
383	B:B:D163	B:B:T143	5.78	Yes	No	1	9	5
384	B:B:D163	B:B:G144	6.71	Yes	No	1	9	8
385	B:B:G162	B:B:Y145	4.35	No	Yes	1	9	8
386	B:B:D186	B:B:Y145	11.49	No	Yes	1	9	8
387	B:B:M188	B:B:Y145	3.59	Yes	Yes	1	8	8
388	B:B:L146	B:B:T159	4.42	No	Yes	0	7	9
389	B:B:M188	B:B:S147	4.6	Yes	No	0	8	9
390	B:B:C148	B:B:S160	3.44	No	Yes	3	6	6
391	B:B:C148	B:B:L190	7.94	No	No	3	6	5
392	B:B:L192	B:B:R150	4.86	No	No	0	5	6
393	B:B:F151	B:B:I157	6.28	Yes	No	0	9	7
394	B:B:L152	B:B:Q156	6.65	Yes	No	0	3	5
395	B:B:L152	B:B:V158	4.47	Yes	No	3	3	5
396	B:B:L152	B:B:L192	5.54	Yes	No	3	3	5
397	B:B:D153	B:B:Q156	3.92	No	No	0	5	5
398	B:B:I171	B:B:N155	5.66	No	No	0	6	3
399	B:B:L168	B:B:Q156	13.31	No	No	0	6	5
400	B:B:L192	B:B:V158	4.47	No	No	3	5	5
401	B:B:F199	B:B:V158	5.24	Yes	No	3	9	5
402	B:B:T159	B:B:W169	4.85	Yes	Yes	0	9	8
403	B:B:C166	B:B:S160	3.44	No	Yes	3	8	6
404	B:B:S160	B:B:V187	8.08	Yes	Yes	3	6	9
405	B:B:L190	B:B:S160	6.01	No	Yes	3	5	6
406	B:B:G162	B:B:S161	3.71	No	No	1	9	9
407	B:B:D163	B:B:S161	10.31	Yes	No	1	9	9
408	B:B:D186	B:B:G162	6.71	No	No	1	9	9
409	B:B:D163	B:B:T165	13.01	Yes	No	1	9	7
410	B:B:T165	B:B:T181	3.14	No	No	0	7	2
411	B:B:C166	B:B:F180	4.19	No	Yes	3	8	7
412	B:B:C166	B:B:V187	5.12	No	Yes	3	8	9
413	B:B:A167	B:B:W169	3.89	No	Yes	24	4	8
414	B:B:A167	B:B:Q176	4.55	No	Yes	24	4	4
415	B:B:L168	B:B:T178	4.42	No	No	0	6	4
416	B:B:Q176	B:B:W169	13.14	Yes	Yes	24	4	8
417	B:B:D170	B:B:T173	10.12	No	No	0	9	5
418	B:B:D170	B:B:T177	4.34	No	No	0	9	4
419	B:B:Q175	B:B:T173	4.25	No	No	0	4	5
420	B:B:Q176	B:B:T179	7.09	Yes	No	0	4	4
421	B:B:F180	B:B:T178	5.19	Yes	No	0	7	4
422	B:B:F180	B:B:F199	8.57	Yes	Yes	3	7	9
423	B:B:F180	B:B:W211	18.04	Yes	Yes	3	7	8
424	B:B:F180	B:B:G216	4.52	Yes	No	0	7	4
425	B:B:H183	B:B:V187	5.54	Yes	Yes	3	9	9
426	B:B:A203	B:B:H183	8.78	No	Yes	3	8	9
427	B:B:D205	B:B:H183	10.08	Yes	Yes	3	9	9
428	B:B:H183	B:B:K209	10.48	Yes	Yes	3	9	6
429	B:B:D205	B:B:T184	5.78	Yes	No	0	9	3
430	B:B:D205	B:B:G185	5.03	Yes	No	0	9	5
431	B:B:S201	B:B:V187	3.23	No	Yes	0	9	9
432	B:B:A203	B:B:V187	5.09	No	Yes	3	8	9
433	B:B:C204	B:B:M188	3.24	Yes	Yes	1	7	8
434	B:B:I232	B:B:S189	4.64	No	No	0	8	7
435	B:B:F234	B:B:S191	6.61	No	No	0	5	8
436	B:B:A193	B:B:F234	6.93	No	No	0	4	5
437	B:B:G238	B:B:P194	4.06	No	No	0	7	4
438	B:B:D195	B:B:R197	3.57	No	No	0	5	5
439	B:B:L198	B:B:L210	4.15	No	Yes	0	3	5
440	B:B:F199	B:B:W211	10.02	Yes	Yes	3	9	8
441	B:B:L210	B:B:V200	4.47	Yes	Yes	0	5	6
442	B:B:I232	B:B:V200	6.14	No	Yes	10	8	6
443	B:B:F234	B:B:V200	9.18	No	Yes	0	5	6
444	B:B:F241	B:B:V200	14.42	Yes	Yes	10	6	6
445	B:B:G202	B:B:S201	3.71	No	No	0	6	9
446	B:B:S201	B:B:W211	4.94	No	Yes	0	9	8
447	B:B:G202	B:B:I229	3.53	No	No	0	6	7
448	B:B:A203	B:B:D205	4.63	No	Yes	3	8	9
449	B:B:C204	B:B:D228	10.89	Yes	Yes	1	7	9
450	B:B:D205	B:B:S207	8.83	Yes	No	0	9	5
451	B:B:K209	B:B:W211	5.8	Yes	Yes	3	6	8
452	B:B:C218	B:B:K209	4.85	No	Yes	3	5	6
453	B:B:K209	B:B:T221	10.51	Yes	No	0	6	7
454	B:B:L210	B:B:R219	4.86	Yes	No	0	5	5
455	B:B:L210	B:B:Q220	3.99	Yes	No	0	5	7
456	B:B:L210	B:B:L255	8.3	Yes	No	0	5	6
457	B:B:C218	B:B:W211	5.22	No	Yes	3	5	8
458	B:B:D212	B:B:E215	6.5	No	No	25	9	3
459	B:B:D212	B:B:R219	10.72	No	No	25	9	5
460	B:B:E215	B:B:R219	9.3	No	No	25	3	5
461	B:B:C218	G:G:Q18	6.1	No	No	0	5	9
462	B:B:F222	B:B:Q220	7.03	Yes	No	10	8	7
463	B:B:D258	B:B:Q220	9.14	Yes	No	10	7	7
464	B:B:T221	G:G:E22	5.64	No	Yes	0	7	9
465	B:B:F222	B:B:F241	9.65	Yes	Yes	10	8	6
466	B:B:F222	B:B:F253	15	Yes	Yes	10	8	6
467	B:B:D258	B:B:F222	4.78	Yes	Yes	10	7	8
468	B:B:H225	B:B:I229	5.3	Yes	No	14	9	7
469	B:B:H225	B:B:T243	6.85	Yes	No	0	9	8
470	B:B:H225	B:B:S245	13.95	Yes	No	14	9	9
471	B:B:D247	B:B:H225	7.56	Yes	Yes	14	9	9
472	B:B:H225	B:B:R251	21.44	Yes	Yes	14	9	8
473	B:B:D247	B:B:E226	5.2	Yes	No	0	9	3
474	B:B:D228	B:B:S227	4.42	Yes	No	0	9	6
475	B:B:D246	B:B:S227	5.89	No	No	0	9	6
476	B:B:D247	B:B:S227	4.42	Yes	No	0	9	6
477	B:B:I229	B:B:S245	4.64	No	No	14	7	9
478	B:B:D246	B:B:N230	9.42	No	No	1	9	9
479	B:B:A231	B:B:V276	3.39	No	No	0	5	6
480	B:B:F241	B:B:I232	6.28	Yes	No	10	6	8
481	B:B:C233	B:B:V276	5.12	No	No	0	3	6
482	B:B:C233	B:B:F278	4.19	No	Yes	0	3	7
483	B:B:F235	B:B:P236	20.23	Yes	No	9	6	7
484	B:B:F235	B:B:N237	12.08	Yes	Yes	9	6	5
485	B:B:F235	B:B:F278	11.79	Yes	Yes	0	6	7
486	B:B:F235	B:B:G282	4.52	Yes	No	9	6	9
487	B:B:F235	G:G:L37	4.87	Yes	No	9	6	7
488	B:B:F235	G:G:Y40	6.19	Yes	Yes	9	6	6
489	B:B:G282	B:B:P236	4.06	No	No	9	9	7
490	B:B:P236	G:G:Y40	11.13	No	Yes	9	7	6
491	B:B:G238	B:B:N237	3.39	No	Yes	0	7	5
492	B:B:N237	B:B:N239	8.17	Yes	No	9	5	2
493	B:B:N237	G:G:D36	4.04	Yes	No	9	5	5
494	B:B:N237	G:G:L37	5.49	Yes	No	9	5	7
495	B:B:N237	G:G:Y40	6.98	Yes	Yes	9	5	6
496	B:B:N239	G:G:D36	4.04	No	No	9	2	5
497	B:B:A240	G:G:L37	4.73	No	No	0	6	7
498	B:B:F241	B:B:F253	9.65	Yes	Yes	10	6	6
499	B:B:A242	B:B:F278	4.16	No	Yes	0	4	7
500	B:B:F253	B:B:T243	9.08	Yes	No	0	6	8
501	B:B:G244	B:B:I273	5.29	No	No	0	5	6
502	B:B:D247	B:B:S245	7.36	Yes	No	14	9	9
503	B:B:D247	B:B:T249	5.78	Yes	No	14	9	6
504	B:B:D247	B:B:R251	3.57	Yes	Yes	14	9	8
505	B:B:R251	B:B:T249	7.76	Yes	No	14	8	6
506	B:B:S265	B:B:T249	6.4	No	No	0	2	6
507	B:B:C250	B:B:Y264	4.03	No	Yes	0	8	5
508	B:B:C250	B:B:I273	3.27	No	No	0	8	6
509	B:B:E260	B:B:R251	6.98	No	Yes	0	6	8
510	B:B:R251	B:B:T263	7.76	Yes	No	0	8	1
511	B:B:L252	B:B:L261	8.3	No	No	0	7	5
512	B:B:L252	B:B:Y264	7.03	No	Yes	0	7	5
513	B:B:E260	B:B:F253	3.5	No	Yes	0	6	6
514	B:B:D254	B:B:R256	4.76	No	Yes	9	9	9
515	B:B:D254	B:B:L261	6.79	No	No	0	9	5
516	B:B:D254	G:G:A33	6.18	No	No	9	9	7
517	B:B:R256	G:G:I28	12.53	Yes	No	0	9	4
518	B:B:R256	G:G:K32	3.71	Yes	No	0	9	5
519	B:B:R256	G:G:A33	4.15	Yes	No	9	9	7
520	B:B:R256	G:G:D36	4.76	Yes	No	9	9	5
521	B:B:A257	G:G:V30	5.09	No	No	0	7	8
522	B:B:D258	G:G:R27	5.96	Yes	No	0	7	8
523	B:B:Q259	G:G:V30	5.73	No	No	0	6	8
524	B:B:M262	B:B:Y264	7.18	Yes	Yes	0	4	5
525	B:B:A302	B:B:M262	3.22	No	Yes	0	2	4
526	B:B:S265	B:B:T263	3.2	No	No	0	2	1
527	B:B:L285	B:B:Y264	4.69	No	Yes	2	6	5
528	B:B:W297	B:B:Y264	6.75	Yes	Yes	2	8	5
529	B:B:H266	B:B:I269	3.98	Yes	No	0	4	4
530	B:B:H266	B:B:R304	4.51	Yes	Yes	0	4	5
531	B:B:I269	B:B:Y289	4.84	No	Yes	0	4	7
532	B:B:C271	B:B:Y289	4.03	No	Yes	2	5	7
533	B:B:C271	B:B:D290	6.22	No	Yes	2	5	6
534	B:B:C271	B:B:D291	7.78	No	No	2	5	8
535	B:B:D290	B:B:G272	3.35	Yes	No	0	6	4
536	B:B:I273	B:B:Y289	4.84	No	Yes	0	6	7
537	B:B:S275	B:B:T274	3.2	No	No	0	8	8
538	B:B:D290	B:B:T274	4.34	Yes	No	2	6	8
539	B:B:R314	B:B:T274	5.17	Yes	No	2	8	8
540	B:B:L318	B:B:S275	9.01	No	No	0	6	8
541	B:B:A287	B:B:V276	3.39	No	No	0	6	6
542	B:B:S277	B:B:V320	4.85	No	No	0	5	7
543	B:B:F278	B:B:L285	14.61	Yes	No	0	7	6
544	B:B:L284	B:B:S279	6.01	No	No	0	5	9
545	B:B:S279	G:G:D48	5.89	No	Yes	4	9	9
546	B:B:S279	G:G:L50	4.5	No	No	4	9	9
547	B:B:K280	G:G:D48	4.15	No	Yes	0	1	9
548	B:B:S281	G:G:D48	8.83	No	Yes	0	9	9
549	B:B:D298	B:B:R283	14.29	No	No	0	9	9
550	B:B:L300	B:B:R283	8.5	No	No	0	6	9
551	B:B:L284	B:B:V296	4.47	No	No	0	5	5
552	B:B:L285	B:B:W297	3.42	No	Yes	2	6	8
553	B:B:L286	B:B:V327	4.47	No	No	0	7	6
554	B:B:A287	B:B:Y289	4	No	Yes	0	6	7
555	B:B:D291	B:B:Y289	3.45	No	Yes	2	8	7
556	B:B:N295	B:B:Y289	10.47	Yes	Yes	2	6	7
557	B:B:W297	B:B:Y289	9.65	Yes	Yes	2	8	7
558	B:B:D290	B:B:R314	13.1	Yes	Yes	2	6	8
559	B:B:D291	B:B:N293	13.46	No	No	2	8	5
560	B:B:N293	B:B:N295	4.09	No	Yes	2	5	6
561	B:B:N293	B:B:V307	5.91	No	No	2	5	3
562	B:B:C294	B:B:L308	4.76	No	No	0	5	7
563	B:B:C294	B:B:V315	5.12	No	No	0	5	7
564	B:B:C294	B:B:T329	5.07	No	No	0	5	8
565	B:B:N295	B:B:R304	9.64	Yes	Yes	0	6	5
566	B:B:N295	B:B:V307	5.91	Yes	No	2	6	3
567	B:B:A305	B:B:V296	3.39	No	No	0	4	5
568	B:B:R304	B:B:W297	10	Yes	Yes	0	5	8
569	B:B:D298	B:B:K301	6.91	No	No	0	9	5
570	B:B:L308	B:B:W339	25.06	No	Yes	4	7	9
571	B:B:H311	B:B:V315	5.54	Yes	No	4	9	7
572	B:B:H311	B:B:T329	8.21	Yes	No	0	9	8
573	B:B:H311	B:B:S331	12.55	Yes	No	4	9	9
574	B:B:D333	B:B:H311	11.35	Yes	Yes	4	9	9
575	B:B:H311	B:B:K337	7.86	Yes	Yes	4	9	6
576	B:B:D312	R:R:R214	8.34	No	No	0	5	7
577	B:B:N313	B:B:W332	5.65	No	Yes	0	7	9
578	B:B:R314	B:B:W332	18.99	Yes	Yes	2	8	9
579	B:B:S331	B:B:V315	6.46	No	No	4	9	7
580	B:B:C317	B:B:S316	3.44	No	No	0	7	9
581	B:B:S316	B:B:W332	6.18	No	Yes	0	9	9
582	B:B:V320	B:B:V327	3.21	No	No	0	7	6
583	B:B:D323	B:B:T321	5.78	No	Yes	8	7	7
584	B:B:G324	B:B:T321	3.64	No	Yes	0	9	7
585	B:B:D323	B:B:M325	4.16	No	Yes	8	7	5
586	B:B:G324	G:G:P49	4.06	No	Yes	0	9	7
587	B:B:M325	G:G:P49	6.71	Yes	Yes	0	5	7
588	B:B:M325	G:G:P60	5.03	Yes	Yes	8	5	9
589	B:B:M325	G:G:F61	3.73	Yes	Yes	8	5	8
590	B:B:A326	B:B:N340	3.13	No	Yes	8	7	9
591	B:B:A326	G:G:F61	5.55	No	Yes	8	7	8
592	B:B:V327	B:B:W339	3.68	No	Yes	0	6	9
593	B:B:A328	B:B:I338	3.25	No	No	0	5	5
594	B:B:T329	B:B:W339	7.28	No	Yes	0	8	9
595	B:B:D333	B:B:S331	8.83	Yes	No	4	9	9
596	B:B:D333	B:B:F335	10.75	Yes	No	4	9	4
597	B:B:F335	R:R:R213	4.28	No	No	4	4	8
598	B:B:K337	B:B:W339	6.96	Yes	Yes	4	6	9
599	B:B:I338	G:G:F61	5.02	No	Yes	8	5	8
600	B:B:N340	G:G:N59	4.09	Yes	No	0	9	9
601	B:B:N340	G:G:F61	4.83	Yes	Yes	8	9	8
602	G:G:I9	G:G:R13	6.26	Yes	No	0	2	6
603	G:G:A10	G:G:R13	4.15	No	No	0	2	6
604	G:G:E17	G:G:K20	9.45	No	No	0	6	6
605	G:G:E22	G:G:Q18	3.82	Yes	No	0	9	9
606	G:G:E22	G:G:L19	10.6	Yes	Yes	0	9	9
607	G:G:I25	G:G:R27	11.27	No	No	0	2	8
608	G:G:A35	G:G:K32	3.21	No	No	0	2	5
609	G:G:H44	G:G:Y40	15.24	No	Yes	0	6	6
610	G:G:E47	G:G:K46	10.8	No	No	0	3	1
611	G:G:D48	G:G:P49	4.83	Yes	Yes	0	9	7
612	G:G:D48	G:G:L50	4.07	Yes	No	4	9	9
613	G:G:P49	G:G:V54	3.53	Yes	No	0	7	6
614	G:G:P55	G:G:V54	3.53	No	No	0	5	6
615	G:G:N59	G:G:V54	7.39	No	No	0	9	6
616	G:G:E58	G:G:P55	7.86	No	No	0	5	5
617	G:G:E58	G:G:S57	5.75	No	No	0	5	6
618	G:G:N59	G:G:P60	4.89	No	Yes	0	9	9
619	G:G:F61	G:G:P60	7.22	Yes	Yes	8	8	9
620	R:R:D185	R:R:R186	7.15	No	No	0	2	5
621	R:R:M189	R:R:R186	9.93	No	No	0	4	5
622	R:R:H442	R:R:L187	3.86	No	No	0	5	5
623	R:R:Y191	R:R:Y195	14.89	No	Yes	0	7	7
624	R:R:M445	R:R:Y191	8.38	No	No	0	6	7
625	R:R:F450	R:R:G194	4.52	Yes	No	0	7	9
626	R:R:I237	R:R:Y195	14.51	No	Yes	0	7	7
627	R:R:S449	R:R:Y195	3.82	No	Yes	0	9	7
628	R:R:F453	R:R:V197	9.18	Yes	No	0	6	5
629	R:R:G452	R:R:S198	3.71	No	No	0	9	9
630	R:R:F453	R:R:S201	3.96	Yes	No	0	6	8
631	R:R:A456	R:R:S201	3.42	No	No	0	8	8
632	R:R:F230	R:R:L202	4.87	Yes	No	0	8	9
633	R:R:L202	R:R:M231	5.65	No	Yes	0	9	8
634	R:R:G452	R:R:L202	5.13	No	No	0	9	9
635	R:R:M231	R:R:T203	4.52	Yes	No	0	8	3
636	R:R:A205	R:R:C460	3.61	No	No	0	9	9
637	R:R:L209	R:R:N220	4.12	No	No	0	7	9
638	R:R:L209	R:R:M224	4.24	No	No	0	7	5
639	R:R:F227	R:R:L209	4.87	No	No	0	9	7
640	R:R:F212	R:R:Y211	11.35	Yes	No	0	7	2
641	R:R:F212	R:R:S473	6.61	Yes	No	0	7	4
642	R:R:H216	R:R:R213	3.39	No	No	0	8	8
643	R:R:E469	R:R:R214	8.14	No	No	0	9	7
644	R:R:L215	R:R:N220	4.12	No	No	0	9	9
645	R:R:E469	R:R:L215	6.63	No	No	0	9	9
646	R:R:H216	R:R:Y221	10.89	No	No	0	8	7
647	R:R:T218	R:R:Y305	9.99	Yes	Yes	0	7	8
648	R:R:E317	R:R:T218	7.06	No	Yes	0	6	7
649	R:R:L321	R:R:T218	7.37	No	Yes	0	6	7
650	R:R:N220	R:R:R219	4.82	No	Yes	0	9	9
651	R:R:H223	R:R:R219	9.03	Yes	Yes	5	9	9
652	R:R:E465	R:R:R219	10.47	No	Yes	0	9	9
653	R:R:R219	W:W:?1	3.22	Yes	Yes	5	9	0
654	R:R:E302	R:R:I222	13.66	Yes	No	0	9	9
655	R:R:I222	R:R:Y305	7.25	No	Yes	0	9	8
656	R:R:E302	R:R:H223	13.54	Yes	Yes	5	9	9
657	R:R:H223	W:W:?1	24.52	Yes	Yes	5	9	0
658	R:R:H225	R:R:W298	17.98	No	Yes	15	8	9
659	R:R:H225	R:R:T325	9.58	No	No	15	8	5
660	R:R:H225	R:R:W329	6.35	No	Yes	15	8	9
661	R:R:F230	R:R:L226	4.87	Yes	No	0	8	9
662	R:R:S229	R:R:T294	4.8	No	Yes	0	9	8
663	R:R:N295	R:R:S229	7.45	No	No	0	8	9
664	R:R:F230	R:R:N295	22.96	Yes	No	0	8	8
665	R:R:F230	R:R:Q451	9.37	Yes	Yes	0	8	9
666	R:R:F230	R:R:V455	5.24	Yes	No	0	8	9
667	R:R:F291	R:R:L232	18.27	Yes	No	0	5	8
668	R:R:L292	R:R:R233	4.86	Yes	Yes	0	6	8
669	R:R:N295	R:R:R233	7.23	No	Yes	0	8	8
670	R:R:N448	R:R:R233	4.82	No	Yes	0	6	8
671	R:R:Q451	R:R:R233	9.35	Yes	Yes	0	9	8
672	R:R:F291	R:R:S236	7.93	Yes	No	0	5	7
673	R:R:F288	R:R:I237	5.02	Yes	No	0	7	7
674	R:R:F288	R:R:K240	12.41	Yes	No	0	7	7
675	R:R:G277	R:R:R282	4.5	No	No	0	4	8
676	R:R:C281	R:R:C351	7.28	No	No	0	9	9
677	R:R:N348	R:R:R282	9.64	No	No	0	7	8
678	R:R:R282	R:R:W352	26.99	No	Yes	0	8	8
679	R:R:D353	R:R:V285	4.38	No	No	0	5	6
680	R:R:T286	R:R:V340	4.76	No	No	0	7	5
681	R:R:F287	R:R:F291	4.29	No	Yes	0	3	5
682	R:R:F288	R:R:L289	3.65	Yes	No	0	7	7
683	R:R:F288	R:R:L292	3.65	Yes	Yes	0	7	6
684	R:R:L289	R:R:W339	6.83	No	Yes	0	7	8
685	R:R:F291	R:R:Y290	8.25	Yes	Yes	0	5	9
686	R:R:T294	R:R:Y290	8.74	Yes	Yes	15	8	9
687	R:R:W329	R:R:Y290	7.72	Yes	Yes	15	9	9
688	R:R:A333	R:R:Y290	5.34	No	Yes	0	5	9
689	R:R:V336	R:R:Y290	5.05	No	Yes	0	7	9
690	R:R:L292	R:R:Y296	3.52	Yes	Yes	12	6	7
691	R:R:L292	R:R:Y421	5.86	Yes	Yes	12	6	8
692	R:R:A293	R:R:P332	3.74	No	No	0	6	9
693	R:R:A293	R:R:I367	3.25	No	No	0	6	7
694	R:R:T294	R:R:W329	6.06	Yes	Yes	15	8	9
695	R:R:P332	R:R:T294	3.5	No	Yes	0	9	8
696	R:R:I367	R:R:Y296	6.04	No	Yes	12	7	7
697	R:R:I371	R:R:Y296	4.84	Yes	Yes	12	7	7
698	R:R:Y296	R:R:Y421	9.93	Yes	Yes	12	7	8
699	R:R:F327	R:R:Y297	5.16	No	Yes	18	5	6
700	R:R:L331	R:R:Y297	10.55	No	Yes	18	4	6
701	R:R:P332	R:R:Y297	15.3	No	Yes	0	9	6
702	R:R:F335	R:R:Y297	4.13	No	Yes	18	5	6
703	R:R:P366	R:R:Y297	5.56	No	Yes	18	9	6
704	R:R:V301	R:R:W298	6.13	No	Yes	0	8	9
705	R:R:T325	R:R:W298	3.64	No	Yes	15	5	9
706	R:R:W298	R:R:W329	24.37	Yes	Yes	15	9	9
707	R:R:I299	R:R:N374	4.25	No	No	0	9	9
708	R:R:I299	W:W:?1	12.1	No	Yes	0	9	0
709	R:R:L300	R:R:L304	5.54	No	No	0	8	5
710	R:R:L300	R:R:S370	7.51	No	No	0	8	7
711	R:R:L300	R:R:L373	8.3	No	No	0	8	7
712	R:R:F324	R:R:V301	3.93	No	No	0	7	8
713	R:R:E302	W:W:?1	15.44	Yes	Yes	5	9	0
714	R:R:L304	R:R:L377	4.15	No	No	0	5	7
715	R:R:L309	R:R:Y305	15.24	No	Yes	0	8	8
716	R:R:F315	R:R:Y305	4.13	No	Yes	0	6	8
717	R:R:F324	R:R:Y305	6.19	No	Yes	0	7	8
718	R:R:I381	R:R:L306	4.28	No	No	0	9	9
719	R:R:F311	R:R:H307	21.5	No	No	26	6	8
720	R:R:H307	R:R:L377	6.43	No	No	0	8	7
721	R:R:H307	R:R:N380	8.93	No	No	26	8	8
722	R:R:F315	R:R:S308	5.28	No	No	0	6	7
723	R:R:F311	R:R:I310	3.77	No	No	0	6	8
724	R:R:F311	R:R:N380	4.83	No	No	26	6	8
725	R:R:F315	R:R:Y320	19.6	No	No	0	6	4
726	R:R:E317	R:R:K318	5.4	No	No	0	6	5
727	R:R:F327	R:R:G328	4.52	No	No	0	5	9
728	R:R:F327	R:R:L331	6.09	No	No	18	5	4
729	R:R:F335	R:R:L331	8.53	No	No	18	5	4
730	R:R:F335	R:R:P366	14.45	No	No	18	5	9
731	R:R:V340	R:R:W339	3.68	No	Yes	20	5	8
732	R:R:R343	R:R:W339	5	No	Yes	20	8	8
733	R:R:W339	R:R:W352	7.5	Yes	Yes	20	8	8
734	R:R:I362	R:R:W339	8.22	No	Yes	0	8	8
735	R:R:I363	R:R:W339	5.87	No	Yes	0	7	8
736	R:R:V340	R:R:W352	3.68	No	Yes	20	5	8
737	R:R:I362	R:R:V342	4.61	No	No	0	8	5
738	R:R:R343	R:R:W352	21.99	No	Yes	20	8	8
739	R:R:R343	R:R:S356	9.22	No	No	0	8	4
740	R:R:A344	R:R:N348	3.13	No	No	0	4	7
741	R:R:K359	R:R:L346	8.46	No	No	0	3	3
742	R:R:C351	R:R:D353	6.22	No	No	0	9	5
743	R:R:K360	R:R:S355	12.24	No	No	0	7	7
744	R:R:K359	R:R:S356	4.59	No	No	0	3	4
745	R:R:N358	R:R:W361	4.52	No	No	0	4	8
746	R:R:K360	R:R:W361	6.96	No	No	0	7	8
747	R:R:Q364	R:R:W361	3.29	No	No	0	7	8
748	R:R:Q364	R:R:Y421	10.15	No	Yes	12	7	8
749	R:R:M425	R:R:Q364	4.08	No	No	12	6	7
750	R:R:P366	R:R:V365	3.53	No	No	0	9	5
751	R:R:I367	R:R:Y421	8.46	No	Yes	12	7	8
752	R:R:G418	R:R:I371	7.05	No	Yes	0	9	7
753	R:R:I371	R:R:Y421	3.63	Yes	Yes	12	7	8
754	R:R:N374	R:R:P415	3.26	No	Yes	0	9	9
755	R:R:F375	R:R:F378	3.22	No	Yes	0	7	9
756	R:R:F375	R:R:I379	5.02	No	No	0	7	5
757	R:R:F378	R:R:V382	3.93	Yes	No	27	9	7
758	R:R:F378	R:R:T410	3.89	Yes	No	27	9	9
759	R:R:F378	R:R:P415	14.45	Yes	Yes	0	9	9
760	R:R:N380	R:R:R383	7.23	No	No	0	8	8
761	R:R:I381	R:R:L385	4.28	No	Yes	0	9	8
762	R:R:I381	R:R:L413	4.28	No	No	0	9	9
763	R:R:T410	R:R:V382	3.17	No	No	27	9	7
764	R:R:R383	R:R:V384	3.92	No	No	0	8	8
765	R:R:E391	R:R:T387	4.23	No	No	0	7	7
766	R:R:L389	R:R:Q402	9.32	No	No	0	8	6
767	R:R:L389	R:R:L406	4.15	No	No	0	8	8
768	R:R:Q402	R:R:T399	4.25	No	No	0	6	6
769	R:R:R400	R:R:R404	7.46	No	No	0	8	6
770	R:R:L407	R:R:R404	3.64	No	No	0	8	6
771	R:R:K408	R:R:R404	7.43	No	No	0	8	6
772	R:R:L407	R:R:L411	4.15	No	No	0	8	8
773	R:R:K408	R:R:V412	4.55	No	No	0	8	8
774	R:R:V412	W:W:?1	3.16	No	Yes	0	8	0
775	R:R:L413	W:W:?1	4.4	No	Yes	0	9	0
776	R:R:M414	R:R:P415	3.35	No	Yes	0	8	9
777	R:R:L416	R:R:M414	4.24	Yes	No	0	9	8
778	R:R:P415	W:W:?1	6.09	Yes	Yes	0	9	0
779	R:R:H420	R:R:L416	7.71	Yes	Yes	0	8	9
780	R:R:L416	W:W:?1	5.13	Yes	Yes	0	9	0
781	R:R:F417	R:R:F447	7.5	No	Yes	5	9	5
782	R:R:F417	R:R:Q451	22.25	No	Yes	5	9	9
783	R:R:F417	W:W:?1	25.16	No	Yes	5	9	0
784	R:R:F424	R:R:H420	4.53	Yes	Yes	5	7	8
785	R:R:H420	R:R:Y443	7.62	Yes	No	5	8	4
786	R:R:F447	R:R:H420	15.84	Yes	Yes	5	5	8
787	R:R:M425	R:R:Y421	3.59	No	Yes	12	6	8
788	R:R:F424	R:R:V423	3.93	Yes	No	0	7	6
789	R:R:F424	R:R:Y443	4.13	Yes	No	5	7	4
790	R:R:E444	R:R:F424	24.49	No	Yes	0	7	7
791	R:R:F424	R:R:F447	6.43	Yes	Yes	5	7	5
792	R:R:P428	R:R:T427	3.5	No	No	0	7	5
793	R:R:Q440	R:R:T427	15.59	No	No	0	6	5
794	R:R:Q440	R:R:W437	3.29	No	No	28	6	5
795	R:R:M441	R:R:W437	13.96	No	No	28	6	5
796	R:R:H442	R:R:Q438	13.6	No	No	0	5	4
797	R:R:M441	R:R:Q440	6.8	No	No	28	6	6
798	R:R:E444	R:R:M445	4.06	No	No	0	7	6
799	R:R:F447	R:R:N448	4.83	Yes	No	0	5	6
800	R:R:F447	R:R:Q451	8.2	Yes	Yes	5	5	9
801	R:R:F450	R:R:S449	6.61	Yes	No	0	7	9
802	R:R:F450	R:R:F453	3.22	Yes	Yes	0	7	6
803	R:R:F450	R:R:F454	5.36	Yes	No	0	7	6
804	R:R:F453	R:R:I457	12.56	Yes	No	0	6	6
805	R:R:V455	R:R:Y459	5.05	No	No	0	9	8
806	R:R:F461	R:R:I457	3.77	No	No	0	8	6
807	R:R:I458	W:W:?1	4.54	No	Yes	0	8	0
808	R:R:Y459	W:W:?1	55.26	No	Yes	0	8	0
809	R:R:E465	R:R:N463	3.94	No	Yes	0	9	9
810	R:R:N463	R:R:V466	5.91	Yes	No	0	9	9
811	R:R:N463	W:W:?1	22.55	Yes	Yes	0	9	0
812	R:R:E469	R:R:K472	8.1	No	No	0	9	7
813	R:R:T478	R:R:W474	6.06	No	No	0	4	5
814	R:R:L481	R:R:W477	6.83	No	No	0	4	4
815	A:A:C365	A:A:D368	3.11	No	Yes	0	8	9
816	B:B:I123	B:B:S136	3.1	Yes	No	0	6	4
817	B:B:A193	B:B:D195	3.09	No	No	0	4	5
818	R:R:I376	R:R:V372	3.07	No	No	0	4	4
819	R:R:I470	R:R:V466	3.07	No	No	0	5	9
820	R:R:K319	R:R:S316	3.06	No	No	0	6	7
821	B:B:I157	B:B:T159	3.04	No	Yes	0	7	9
822	R:R:M231	R:R:V206	3.04	Yes	No	0	8	5
823	B:B:A26	B:B:Q259	3.03	No	No	0	3	6
824	B:B:T34	G:G:M38	3.01	No	No	0	5	4
825	R:R:M189	R:R:T192	3.01	No	No	0	4	7
826	B:B:T181	G:G:K14	3	No	No	0	2	4
827	A:A:N50	A:A:S51	2.98	Yes	No	0	9	9
828	R:R:L199	R:R:V235	2.98	No	No	0	7	4
829	R:R:L228	R:R:V206	2.98	No	No	0	4	5
830	R:R:L289	R:R:V285	2.98	No	No	0	7	6
831	R:R:L436	R:R:V439	2.98	No	No	0	4	5
832	B:B:L152	B:B:T196	2.95	Yes	No	0	3	1
833	B:B:L168	B:B:T177	2.95	No	No	0	6	4
834	G:G:L51	G:G:T52	2.95	No	No	0	6	4
835	A:A:I245	A:A:I375	2.94	No	No	0	7	9
836	A:A:D295	A:A:S366	2.94	No	No	0	9	9
837	G:G:A43	G:G:H44	2.93	No	No	0	4	6
838	A:A:I26	A:A:L30	2.85	No	No	0	9	5
839	A:A:L30	B:B:I80	2.85	No	Yes	0	5	8
840	A:A:I245	A:A:L43	2.85	No	No	0	7	7
841	A:A:I235	A:A:L282	2.85	No	Yes	0	9	9
842	A:A:I244	A:A:L282	2.85	No	Yes	22	8	9
843	A:A:I285	A:A:L282	2.85	No	Yes	22	7	9
844	B:B:L4	G:G:I9	2.85	No	Yes	0	4	2
845	B:B:L7	G:G:I9	2.85	No	Yes	0	8	2
846	A:A:I56	A:A:N292	2.83	No	No	0	7	9
847	R:R:L199	R:R:M231	2.83	No	Yes	0	7	8
848	R:R:L368	R:R:M425	2.83	No	No	0	4	6
849	A:A:E370	A:A:T369	2.82	No	No	0	4	9
850	B:B:G182	B:B:W211	2.81	No	Yes	0	6	8
851	B:B:G310	B:B:W339	2.81	No	Yes	0	5	9
852	A:A:M60	A:A:N371	2.8	No	Yes	0	9	9
853	B:B:C25	G:G:R27	2.79	No	No	0	3	8
854	B:B:F235	G:G:C41	2.79	Yes	No	0	6	7
855	R:R:C460	R:R:F227	2.79	No	No	0	9	9
856	A:A:A337	A:A:F315	2.77	No	Yes	0	8	6
857	B:B:D27	G:G:K29	2.77	No	No	0	8	4
858	B:B:A104	B:B:F151	2.77	No	Yes	0	7	9
859	B:B:A113	B:B:F151	2.77	No	Yes	0	9	9
860	B:B:A208	B:B:F222	2.77	No	Yes	10	6	8
861	B:B:A208	B:B:F241	2.77	No	Yes	10	6	6
862	B:B:A299	B:B:F278	2.77	No	Yes	0	5	7
863	B:B:A309	R:R:R476	2.77	No	No	0	3	7
864	A:A:K216	A:A:Q213	2.71	No	No	0	4	3
865	A:A:D295	A:A:L296	2.71	No	Yes	0	9	6
866	B:B:D66	B:B:L69	2.71	No	No	0	8	5
867	G:G:E17	G:G:M21	2.71	No	No	0	6	1
868	G:G:D48	G:G:L51	2.71	Yes	No	0	9	6
869	R:R:E391	R:R:K388	2.7	No	Yes	0	7	9
870	A:A:A372	A:A:Y63	2.67	No	No	0	8	9
871	R:R:A234	R:R:Y195	2.67	No	Yes	0	8	7
872	B:B:D312	B:B:D333	2.66	No	Yes	0	5	9
873	A:A:H41	A:A:I383	2.65	No	No	0	6	8
874	A:A:H387	A:A:I383	2.65	No	No	0	8	8
875	B:B:E172	B:B:N155	2.63	No	No	0	6	3
876	B:B:F199	B:B:V213	2.62	Yes	No	0	9	4
877	R:R:F461	R:R:V204	2.62	No	No	0	8	5
878	R:R:R390	R:R:T387	2.59	No	No	0	6	7
879	B:B:H266	B:B:N268	2.55	Yes	No	0	4	4
880	R:R:S316	R:R:Y320	2.54	No	No	0	7	4
881	A:A:F246	A:A:I276	2.51	No	No	0	9	8
882	B:B:I123	B:B:R137	2.51	Yes	No	0	6	5
883	R:R:F212	R:R:I208	2.51	Yes	No	0	7	8
884	A:A:T325	A:A:Y339	2.5	No	Yes	0	2	3
885	R:R:F212	R:R:L215	2.44	Yes	No	0	7	9
886	B:B:I123	B:B:Y111	2.42	Yes	No	0	6	4
887	B:B:F292	B:B:N313	2.42	No	No	0	4	7
888	R:R:K360	R:R:Y429	2.39	No	No	0	7	6
889	B:B:Q259	B:B:R22	2.34	No	No	0	6	6
890	R:R:Q401	R:R:R400	2.34	No	No	0	6	8
891	B:B:G115	B:B:G116	2.11	No	No	0	9	9
892	R:R:G277	R:R:G350	2.11	No	No	0	4	5
893	B:B:C317	B:B:G330	1.96	No	No	0	7	5
894	A:A:A226	A:A:G206	1.95	No	Yes	0	9	8
895	B:B:A305	B:B:G306	1.95	No	No	0	4	4
896	R:R:A333	R:R:G330	1.95	No	No	0	5	7
897	B:B:A106	B:B:P107	1.87	No	No	0	6	6
898	R:R:W474	R:R:W477	1.87	No	No	0	5	4
899	A:A:G206	A:A:S205	1.86	Yes	No	0	8	7
900	B:B:G288	B:B:S275	1.86	No	No	0	7	8
901	B:B:G41	B:B:V40	1.84	No	No	0	1	3
902	R:R:G194	R:R:V193	1.84	No	No	0	9	6
903	R:R:G280	R:R:V283	1.84	No	No	0	4	4
904	B:B:G131	B:B:T128	1.82	No	No	0	4	3
905	B:B:G224	B:B:T223	1.82	No	No	0	6	2
906	R:R:G350	R:R:T349	1.82	No	No	0	5	5
907	B:B:A60	B:B:C103	1.81	No	No	0	7	8
908	B:B:P107	B:B:T65	1.75	No	No	0	6	1
909	G:G:P53	G:G:T52	1.75	No	No	0	8	4
910	A:A:G304	A:A:K305	1.74	No	No	0	5	3
911	A:A:L30	B:B:G53	1.71	No	No	0	5	9
912	B:B:C103	B:B:V71	1.71	No	Yes	0	8	8
913	R:R:G303	R:R:L377	1.71	No	No	0	9	7
914	A:A:A298	A:A:V334	1.7	No	Yes	0	4	4
915	B:B:A11	G:G:V16	1.7	No	No	0	5	7
916	B:B:A309	B:B:V307	1.7	No	No	0	3	3
917	R:R:A284	R:R:V239	1.7	No	No	0	6	5
918	R:R:A242	R:R:V243	1.7	No	No	0	4	5
919	R:R:G357	R:R:N358	1.7	No	No	0	6	4
920	R:R:G464	R:R:N463	1.7	No	Yes	0	7	9
921	R:R:C217	R:R:T218	1.69	No	Yes	0	8	7
922	R:R:A347	R:R:T349	1.68	No	No	0	7	5
923	B:B:K301	B:B:P39	1.67	No	No	0	5	1
924	A:A:I383	R:R:A313	1.62	No	No	0	8	7
925	B:B:I33	G:G:A34	1.62	No	No	0	3	6
926	B:B:A140	B:B:I120	1.62	No	No	0	5	6
927	B:B:A248	B:B:I269	1.62	No	No	0	5	4
928	R:R:S196	R:R:V193	1.62	No	No	0	7	6
929	A:A:A372	A:A:M60	1.61	No	No	0	8	9
930	A:A:D331	A:A:P332	1.61	Yes	No	0	4	1
931	B:B:D38	B:B:P39	1.61	No	No	0	1	1
932	R:R:A210	R:R:M224	1.61	No	No	0	4	5
933	R:R:A284	R:R:K240	1.61	No	No	0	6	7
934	B:B:S207	B:B:T223	1.6	No	No	0	5	2
935	R:R:S341	R:R:T345	1.6	No	No	0	5	3
936	R:R:S475	R:R:T478	1.6	No	No	0	4	4
937	B:B:A11	G:G:L19	1.58	No	Yes	0	5	9
938	B:B:L30	G:G:A34	1.58	No	No	0	5	6
939	G:G:A45	G:G:L51	1.58	No	No	0	4	6
940	R:R:A386	R:R:L406	1.58	No	No	0	6	8
941	A:A:A19	B:B:N88	1.56	No	Yes	0	4	7
942	A:A:I276	A:A:S275	1.55	No	No	0	8	8
943	R:R:I190	R:R:V193	1.54	No	No	0	6	6
944	R:R:I362	R:R:V338	1.54	No	No	0	8	5
945	B:B:M262	B:B:S31	1.53	Yes	No	0	4	1
946	R:R:K405	R:R:S409	1.53	No	No	0	8	9
947	A:A:M221	A:A:V57	1.52	No	No	0	8	7
948	A:A:I285	A:A:T284	1.52	No	No	0	7	4
949	B:B:A28	B:B:Q32	1.52	No	No	0	4	1
950	A:A:A316	A:A:E309	1.51	No	No	0	2	4
951	G:G:A39	G:G:E42	1.51	No	No	0	3	1
952	A:A:L393	R:R:S409	1.5	Yes	No	5	8	9
953	R:R:L385	R:R:S409	1.5	Yes	No	5	8	9
954	R:R:L446	R:R:S449	1.5	No	No	0	5	9
955	R:R:L416	R:R:V419	1.49	Yes	No	0	9	7
956	A:A:V20	B:B:N88	1.48	No	Yes	0	3	7
957	B:B:I123	B:B:I171	1.47	Yes	No	0	6	6
958	B:B:I157	B:B:I171	1.47	No	No	0	7	6
959	R:R:I371	R:R:I422	1.47	Yes	No	0	7	5
960	R:R:L389	R:R:T392	1.47	No	No	0	8	7
961	B:B:A206	B:B:H225	1.46	No	Yes	0	4	9
962	B:B:L14	G:G:K20	1.41	No	No	0	8	6
963	R:R:G323	R:R:W322	1.41	No	No	0	1	3
964	B:B:H54	B:B:S334	1.39	Yes	No	0	9	4
965	R:R:A242	R:R:F238	1.39	No	No	0	4	7
966	A:A:K32	A:A:Q29	1.36	No	No	0	4	4
967	R:R:D241	R:R:L244	1.36	No	No	0	8	5
968	R:R:E444	R:R:M441	1.35	No	No	0	7	6
969	A:A:E299	A:A:L296	1.33	No	Yes	0	6	6
970	B:B:L14	B:B:Q17	1.33	No	No	0	8	4
971	R:R:R476	R:R:S475	1.32	No	No	0	7	4
972	R:R:F287	R:R:V283	1.31	No	No	0	3	4
973	A:A:Q390	R:R:E465	1.27	No	No	0	4	9
974	B:B:D267	B:B:H266	1.26	No	Yes	0	3	4
975	A:A:K58	A:A:R61	1.24	No	No	0	9	8
976	B:B:D212	B:B:R214	1.19	No	No	0	9	9
977	B:B:D303	B:B:R304	1.19	No	Yes	0	2	5
978	A:A:E314	A:A:R317	1.16	Yes	No	0	6	2
979	B:B:E12	B:B:R8	1.16	No	No	0	4	3
980	R:R:K318	R:R:W322	1.16	No	No	0	5	3
981	R:R:Q438	R:R:W437	1.1	No	No	0	4	5
982	R:R:R400	R:R:Y403	1.03	No	No	0	8	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	A:A:N50	6.6675	4	0	9
2	A:A:K53	5.85	4	23	9
3	A:A:G206	2.6225	4	0	8
4	A:A:F219	7.732	5	0	8
5	A:A:F222	10.845	4	1	7
6	A:A:K233	6.09333	6	1	9
7	A:A:W234	6.6975	4	0	9
8	A:A:F238	8.954	5	1	9
9	A:A:D249	9.6475	4	0	8
10	A:A:Y253	7.23	5	0	8
11	A:A:F273	5.874	5	6	9
12	A:A:W277	9.246	5	6	6
13	A:A:L282	5.2275	4	22	9
14	A:A:L289	4.894	5	6	9
15	A:A:F290	6.642	5	16	9
16	A:A:Q294	5.854	5	6	6
17	A:A:L296	3.9225	4	0	6
18	A:A:I308	8.3475	4	13	7
19	A:A:F312	6.1125	4	13	8
20	A:A:E314	5.392	5	13	6
21	A:A:F315	12.094	5	13	6
22	A:A:Y318	9.765	4	0	6
23	A:A:E330	6.1075	4	6	3
24	A:A:D331	6.5875	4	0	4
25	A:A:V334	4.8875	4	0	4
26	A:A:K338	7.7775	4	6	5
27	A:A:Y339	6.456	5	0	3
28	A:A:F340	10.4	6	13	7
29	A:A:F345	8.7	4	6	8
30	A:A:F363	7.3525	4	6	5
31	A:A:T364	6.932	5	16	9
32	A:A:D368	6.8875	4	16	9
33	A:A:N371	7.37	5	16	9
34	A:A:F376	6.114	5	19	8
35	A:A:R385	8.855	4	17	5
36	A:A:Y391	7.70833	6	5	4
37	A:A:L393	3.494	5	5	8
38	B:B:H54	7.58167	6	11	9
39	B:B:K57	13.3175	4	2	9
40	B:B:W63	6.94	5	0	7
41	B:B:V71	4.325	4	7	8
42	B:B:D76	6.68	5	21	9
43	B:B:L79	5.4125	4	7	7
44	B:B:I80	8.3075	4	11	8
45	B:B:W82	9.55833	6	11	9
46	B:B:N88	5.555	4	0	7
47	B:B:K89	6.72	5	11	9
48	B:B:H91	5.5525	4	0	5
49	B:B:I93	6.6375	4	7	7
50	B:B:L95	4.874	5	7	8
51	B:B:W99	9.68333	6	1	9
52	B:B:M101	6.5775	4	0	9
53	B:B:Y105	4.72	5	7	6
54	B:B:V112	5.13	4	7	8
55	B:B:I123	2.756	5	0	6
56	B:B:Y124	5.15286	7	7	6
57	B:B:H142	8.4325	4	1	9
58	B:B:Y145	5.76286	7	1	8
59	B:B:F151	4.3425	4	0	9
60	B:B:L152	4.9025	4	3	3
61	B:B:T159	4.105	4	0	9
62	B:B:S160	5.2425	4	3	6
63	B:B:D163	8.926	5	1	9
64	B:B:W169	10.595	4	24	8
65	B:B:Q176	7.0175	4	24	4
66	B:B:F180	8.102	5	3	7
67	B:B:H183	8.72	4	3	9
68	B:B:V187	5.412	5	3	9
69	B:B:M188	5.3775	4	1	8
70	B:B:F199	6.6125	4	3	9
71	B:B:V200	8.5525	4	10	6
72	B:B:C204	5.79	4	1	7
73	B:B:D205	6.87	5	3	9
74	B:B:K209	7.91	4	3	6
75	B:B:L210	5.154	5	0	5
76	B:B:W211	7.805	6	3	8
77	B:B:F222	7.846	5	10	8
78	B:B:H225	9.42667	6	14	9
79	B:B:D228	8.485	4	1	9
80	B:B:F235	8.92428	7	9	6
81	B:B:N237	6.69167	6	9	5
82	B:B:F241	8.554	5	10	6
83	B:B:D247	5.64833	6	14	9
84	B:B:R251	9.502	5	14	8
85	B:B:F253	9.3075	4	10	6
86	B:B:R256	5.982	5	9	9
87	B:B:D258	7.9475	4	10	7
88	B:B:M262	5.1025	4	0	4
89	B:B:Y264	5.936	5	2	5
90	B:B:H266	3.075	4	0	4
91	B:B:F278	7.504	5	0	7
92	B:B:Y289	5.89714	7	2	7
93	B:B:D290	6.742	5	2	6
94	B:B:N295	7.5275	4	2	6
95	B:B:W297	7.455	4	2	8
96	B:B:R304	6.335	4	0	5
97	B:B:H311	9.102	5	4	9
98	B:B:R314	13.818	5	2	8
99	B:B:T321	6.7775	4	8	7
100	B:B:M325	4.9075	4	8	5
101	B:B:W332	12.846	5	2	9
102	B:B:D333	8.3975	4	4	9
103	B:B:K337	8.96	4	4	6
104	B:B:W339	8.58571	7	4	9
105	B:B:N340	4.52	4	8	9
106	G:G:I9	4.015	4	0	2
107	G:G:L19	5.14	4	0	9
108	G:G:E22	6.04	4	0	9
109	G:G:Y40	9.885	4	9	6
110	G:G:D48	5.08	6	4	9
111	G:G:P49	4.7825	4	0	7
112	G:G:P60	7.415	4	8	9
113	G:G:F61	5.3	8	8	8
114	R:R:Y195	8.9725	4	0	7
115	R:R:F212	5.7275	4	0	7
116	R:R:T218	6.5275	4	0	7
117	R:R:R219	7.978	5	5	9
118	R:R:H223	12.59	4	5	9
119	R:R:F230	9.462	5	0	8
120	R:R:M231	4.01	4	0	8
121	R:R:R233	6.565	4	0	8
122	R:R:F288	6.1825	4	0	7
123	R:R:Y290	7.02	5	15	9
124	R:R:F291	9.685	4	0	5
125	R:R:L292	4.4725	4	12	6
126	R:R:T294	5.775	4	15	8
127	R:R:Y296	6.0825	4	12	7
128	R:R:Y297	8.14	5	18	6
129	R:R:W298	13.03	4	15	9
130	R:R:E302	11.7825	4	5	9
131	R:R:Y305	8.56	5	0	8
132	R:R:W329	11.125	4	15	9
133	R:R:W339	6.18333	6	20	8
134	R:R:W352	15.04	4	20	8
135	R:R:I371	4.2475	4	12	7
136	R:R:F378	6.3725	4	27	9
137	R:R:L385	3.924	5	5	8
138	R:R:K388	7.645	4	17	9
139	R:R:P415	6.7875	4	0	9
140	R:R:L416	4.6425	4	0	9
141	R:R:H420	8.925	4	5	8
142	R:R:Y421	6.93667	6	12	8
143	R:R:F424	8.702	5	5	7
144	R:R:F447	8.56	5	5	5
145	R:R:F450	4.9275	4	0	7
146	R:R:Q451	12.2925	4	5	9
147	R:R:F453	7.23	4	0	6
148	R:R:N463	8.525	4	0	9
149	W:W:?1	13.8643	14	5	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	B:B:K78	B:B:P94	10.0061	3.35	No	No	0	8	5
2	B:B:D76	B:B:K78	11.0441	4.15	Yes	No	0	9	8
3	B:B:D76	B:B:S74	12.3234	10.31	Yes	No	0	9	9
4	B:B:H54	B:B:S74	12.5813	12.55	Yes	No	0	9	9
5	B:B:H54	B:B:W82	13.2715	7.41	Yes	Yes	11	9	9
6	B:B:Q75	B:B:W99	52.0203	8.76	No	Yes	0	9	9
7	B:B:K57	B:B:Q75	97.1866	13.56	Yes	No	0	9	9
8	B:B:K57	B:B:W332	96.9489	24.37	Yes	Yes	2	9	9
9	B:B:S316	B:B:W332	91.5071	6.18	No	Yes	0	9	9
10	B:B:C317	B:B:S316	91.4417	3.44	No	No	0	7	9
11	B:B:C317	B:B:M61	91.3137	4.86	No	No	0	7	6
12	B:B:M61	B:B:W63	91.3253	5.82	No	Yes	0	6	7
13	B:B:L70	B:B:W63	17.8756	9.11	No	Yes	0	5	7
14	B:B:L70	B:B:W82	16.8455	5.69	No	Yes	11	5	9
15	A:A:F219	A:A:H41	21.3544	9.05	Yes	No	0	8	6
16	A:A:H41	A:A:I383	21.3765	2.65	No	No	0	6	8
17	A:A:H387	A:A:I383	21.2878	2.65	No	No	0	8	8
18	A:A:H387	R:R:L309	21.3141	16.71	No	No	0	8	8
19	R:R:L309	R:R:Y305	21.3424	15.24	No	Yes	0	8	8
20	R:R:I222	R:R:Y305	20.0726	7.25	No	Yes	0	9	8
21	R:R:E302	R:R:I222	20.8367	13.66	Yes	No	0	9	9
22	A:A:Y391	R:R:R219	10.8519	12.35	Yes	Yes	5	4	9
23	R:R:N220	R:R:R219	88.8732	4.82	No	Yes	0	9	9
24	R:R:L215	R:R:N220	89.904	4.12	No	No	0	9	9
25	R:R:E469	R:R:L215	90.6457	6.63	No	No	0	9	9
26	R:R:E469	R:R:R214	90.9814	8.14	No	No	0	9	7
27	B:B:D312	R:R:R214	91.1494	8.34	No	No	0	5	7
28	B:B:D312	B:B:D333	91.3357	2.66	No	Yes	0	5	9
29	B:B:D333	B:B:H311	91.0223	11.35	Yes	Yes	4	9	9
30	B:B:H311	B:B:T329	45.6444	8.21	Yes	No	0	9	8
31	B:B:T329	B:B:W339	45.5711	7.28	No	Yes	0	8	9
32	B:B:M45	B:B:W339	91.9351	5.82	No	Yes	4	4	9
33	B:B:M45	G:G:L50	92.4814	4.24	No	No	4	4	9
34	G:G:D48	G:G:L50	91.43	4.07	Yes	No	4	9	9
35	G:G:D48	G:G:P49	92.583	4.83	Yes	Yes	0	9	7
36	B:B:G324	G:G:P49	87.8019	4.06	No	Yes	0	9	7
37	B:B:G324	B:B:T321	87.8044	3.64	No	Yes	0	9	7
38	B:B:T321	B:B:W63	88.0926	9.7	Yes	Yes	0	7	7
39	R:R:E302	W:W:?1	10.7445	15.44	Yes	Yes	5	9	0
40	R:R:R219	W:W:?1	71.1903	3.22	Yes	Yes	5	9	0
41	B:B:H311	B:B:K337	45.645	7.86	Yes	Yes	4	9	6
42	B:B:K337	B:B:W339	46.3941	6.96	Yes	Yes	4	6	9
43	A:A:F238	B:B:W99	28.341	14.03	Yes	Yes	1	9	9
44	A:A:K53	A:A:S51	25.9079	4.59	Yes	No	0	9	9
45	A:A:N50	A:A:S51	26.1264	2.98	Yes	No	0	9	9
46	A:A:D249	A:A:N50	13.5008	12.12	Yes	Yes	0	8	9
47	A:A:D249	A:A:D252	14.023	3.99	Yes	No	0	8	8
48	A:A:D252	A:A:N264	26.9345	6.73	No	No	0	8	9
49	A:A:N264	A:A:Y311	26.9296	11.63	No	No	0	9	6
50	A:A:Y253	A:A:Y311	26.7564	5.96	Yes	No	0	8	6
51	A:A:L297	A:A:Y253	26.5076	3.52	No	Yes	0	8	8
52	A:A:L297	A:A:Q294	26.4264	6.65	No	Yes	6	8	6
53	A:A:L291	A:A:Q294	25.7033	6.65	No	Yes	6	8	6
54	A:A:L289	A:A:L291	27.0891	4.15	Yes	No	6	9	8
55	A:A:F246	A:A:L289	27.6433	3.65	No	Yes	0	9	9
56	A:A:D272	A:A:F246	27.6346	4.78	No	No	0	8	9
57	A:A:D272	A:A:R231	27.6353	9.53	No	No	0	8	9
58	A:A:R231	A:A:W234	27.4053	7	No	Yes	0	9	9
59	A:A:F238	A:A:W234	27.7309	4.01	Yes	Yes	0	9	9
60	A:A:N50	A:A:R265	12.8619	8.44	Yes	No	0	9	9
61	A:A:D252	A:A:R265	12.9315	5.96	No	No	0	8	9
62	A:A:K53	A:A:L45	25.5326	5.64	Yes	No	23	9	8
63	A:A:L45	A:A:M221	25.504	4.24	No	No	0	8	8
64	A:A:D378	A:A:Y360	17.6059	10.34	No	No	0	7	8
65	A:A:D381	A:A:Y360	18.3752	3.45	No	No	0	8	8
66	A:A:D381	R:R:K388	18.5733	12.44	No	Yes	17	8	9
67	A:A:Q384	R:R:K388	21.9436	6.78	No	Yes	0	6	9
68	A:A:Q384	A:A:R380	22.1971	3.5	No	No	0	6	7
69	A:A:F376	A:A:R380	22.4505	3.21	Yes	No	0	8	7
70	A:A:F219	A:A:F376	24.2188	6.43	Yes	Yes	0	8	8
71	A:A:D378	A:A:H362	11.0407	12.61	No	No	0	7	9
72	B:B:M101	B:B:Y145	45.341	4.79	Yes	Yes	0	9	8
73	B:B:M101	B:B:Y59	45.485	13.17	Yes	No	0	9	8
74	B:B:Q75	B:B:Y59	45.5556	3.38	No	No	0	9	8
75	B:B:L117	B:B:Y145	68.1768	3.52	No	Yes	1	9	8
76	B:B:L117	B:B:W99	67.7166	4.56	No	Yes	1	9	9
77	A:A:F212	A:A:F219	25.0717	9.65	No	Yes	0	9	8
78	A:A:K233	B:B:Y145	100	3.58	Yes	Yes	1	9	8
79	A:A:K233	B:B:D228	49.7651	5.53	Yes	Yes	1	9	9
80	A:A:K233	B:B:D246	49.5626	5.53	Yes	No	1	9	9
81	B:B:R314	B:B:W332	20.6944	18.99	Yes	Yes	2	8	9
82	B:B:D290	B:B:R314	19.1695	13.1	Yes	Yes	2	6	8
83	B:B:D228	B:B:S227	49.5425	4.42	Yes	No	0	9	6
84	B:B:D247	B:B:S227	98.5653	4.42	Yes	No	0	9	6
85	B:B:D247	B:B:H225	48.2958	7.56	Yes	Yes	14	9	9
86	B:B:H225	B:B:I229	27.1945	5.3	Yes	No	14	9	7
87	B:B:G202	B:B:I229	53.4483	3.53	No	No	0	6	7
88	B:B:G202	B:B:S201	52.6553	3.71	No	No	0	6	9
89	B:B:S201	B:B:W211	38.2523	4.94	No	Yes	0	9	8
90	B:B:K209	B:B:W211	10.4295	5.8	Yes	Yes	3	6	8
91	G:G:E22	G:G:L19	23.9916	10.6	Yes	Yes	0	9	9
92	B:B:D246	B:B:S227	49.4065	5.89	No	No	0	9	6
93	B:B:D247	B:B:S245	27.4461	7.36	Yes	No	14	9	9
94	B:B:I229	B:B:S245	27.0508	4.64	No	No	14	7	9
95	B:B:C218	B:B:W211	10.4308	5.22	No	Yes	3	5	8
96	B:B:H225	B:B:T243	20.5659	6.85	Yes	No	0	9	8
97	B:B:F253	B:B:T243	20.1615	9.08	Yes	No	0	6	8
98	B:B:F222	B:B:F253	25.6577	15	Yes	Yes	10	8	6
99	B:B:D258	B:B:F222	17.6137	4.78	Yes	Yes	10	7	8
100	B:B:D258	B:B:R22	14.5099	11.91	Yes	No	0	7	6
101	B:B:I18	B:B:R22	10.5469	6.26	No	No	0	7	6
102	B:B:D247	B:B:R251	21.2637	3.57	Yes	Yes	14	9	8
103	B:B:E260	B:B:R251	20.4797	6.98	No	Yes	0	6	8
104	B:B:E260	B:B:F253	20.072	3.5	No	Yes	0	6	6
105	B:B:L14	G:G:L19	11.998	4.15	No	Yes	0	8	9
106	B:B:C271	B:B:D290	18.7905	6.22	No	Yes	2	5	6
107	B:B:C271	B:B:Y289	16.3654	4.03	No	Yes	2	5	7
108	B:B:W297	B:B:Y289	11.135	9.65	Yes	Yes	2	8	7
109	B:B:G162	B:B:Y145	11.6163	4.35	No	Yes	1	9	8
110	B:B:G162	B:B:S161	11.4053	3.71	No	No	1	9	9
111	B:B:S201	B:B:V187	13.6494	3.23	No	Yes	0	9	9
112	B:B:F241	B:B:F253	13.769	9.65	Yes	Yes	10	6	6
113	B:B:F241	B:B:V200	10.5456	14.42	Yes	Yes	10	6	6
114	R:R:L416	W:W:?1	10.5048	5.13	Yes	Yes	0	9	0
115	R:R:E444	R:R:F424	16.907	24.49	No	Yes	0	7	7
116	R:R:F417	W:W:?1	45.3293	25.16	No	Yes	5	9	0
117	R:R:E444	R:R:M445	11.4377	4.06	No	No	0	7	6
118	R:R:M445	R:R:Y191	10.8365	8.38	No	No	0	6	7
119	R:R:Y191	R:R:Y195	10.2443	14.89	No	Yes	0	7	7
120	R:R:F417	R:R:Q451	35.4763	22.25	No	Yes	5	9	9
121	R:R:Q451	R:R:R233	26.3993	9.35	Yes	Yes	0	9	8
122	R:R:L292	R:R:R233	20.6114	4.86	Yes	Yes	0	6	8
123	R:R:F288	R:R:L292	14.1847	3.65	Yes	Yes	0	7	6
124	R:R:S449	R:R:Y195	13.6515	3.82	No	Yes	0	9	7
125	R:R:F450	R:R:S449	11.8336	6.61	Yes	No	0	7	9
126	R:R:F230	R:R:N295	11.5142	22.96	Yes	No	0	8	8
127	R:R:N295	R:R:S229	16.419	7.45	No	No	0	8	9
128	R:R:S229	R:R:T294	15.6356	4.8	No	Yes	0	9	8
129	A:A:F212	A:A:M221	25.1014	4.98	No	No	0	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
A:A:L393	A:A:Y391	3.52	5	Yes	Yes	8	4	2	1
A:A:Y391	R:R:R219	12.35	5	Yes	Yes	4	9	1	1
A:A:Y391	R:R:H223	3.27	5	Yes	Yes	4	9	1	1
A:A:Y391	R:R:E302	4.49	5	Yes	Yes	4	9	1	1
A:A:Y391	R:R:L306	16.41	5	Yes	No	4	9	1	2
A:A:Y391	W:W:?1	6.21	5	Yes	Yes	4	0	1	0
A:A:E392	W:W:?1	6.32	0	No	Yes	6	0	1	0
A:A:L393	R:R:L413	4.15	5	Yes	No	8	9	2	1
R:R:N220	R:R:R219	4.82	0	No	Yes	9	9	2	1
R:R:H223	R:R:R219	9.03	5	Yes	Yes	9	9	1	1
R:R:E465	R:R:R219	10.47	0	No	Yes	9	9	2	1
R:R:R219	W:W:?1	3.22	5	Yes	Yes	9	0	1	0
R:R:E302	R:R:I222	13.66	5	Yes	No	9	9	1	2
R:R:E302	R:R:H223	13.54	5	Yes	Yes	9	9	1	1
R:R:H223	W:W:?1	24.52	5	Yes	Yes	9	0	1	0
R:R:I299	R:R:N374	4.25	0	No	No	9	9	1	2
R:R:I299	W:W:?1	12.1	0	No	Yes	9	0	1	0
R:R:E302	W:W:?1	15.44	5	Yes	Yes	9	0	1	0
R:R:I381	R:R:L306	4.28	0	No	No	9	9	2	2
R:R:N374	R:R:P415	3.26	0	No	Yes	9	9	2	1
R:R:F378	R:R:P415	14.45	27	Yes	Yes	9	9	2	1
R:R:I381	R:R:L413	4.28	0	No	No	9	9	2	1
R:R:K408	R:R:V412	4.55	0	No	No	8	8	2	1
R:R:V412	W:W:?1	3.16	0	No	Yes	8	0	1	0
R:R:L413	W:W:?1	4.4	0	No	Yes	9	0	1	0
R:R:M414	R:R:P415	3.35	0	No	Yes	8	9	2	1
R:R:L416	R:R:M414	4.24	0	Yes	No	9	8	1	2
R:R:P415	W:W:?1	6.09	0	Yes	Yes	9	0	1	0
R:R:H420	R:R:L416	7.71	5	Yes	Yes	8	9	2	1
R:R:L416	W:W:?1	5.13	0	Yes	Yes	9	0	1	0
R:R:F417	R:R:F447	7.5	5	No	Yes	9	5	1	2
R:R:F417	R:R:Q451	22.25	5	No	Yes	9	9	1	2
R:R:F417	W:W:?1	25.16	5	No	Yes	9	0	1	0
R:R:F447	R:R:H420	15.84	5	Yes	Yes	5	8	2	2
R:R:F447	R:R:Q451	8.2	5	Yes	Yes	5	9	2	2
R:R:V455	R:R:Y459	5.05	0	No	No	9	8	2	1
R:R:I458	W:W:?1	4.54	0	No	Yes	8	0	1	0
R:R:Y459	W:W:?1	55.26	0	No	Yes	8	0	1	0
R:R:E465	R:R:N463	3.94	0	No	Yes	9	9	2	1
R:R:N463	R:R:V466	5.91	0	Yes	No	9	9	1	2
R:R:N463	W:W:?1	22.55	0	Yes	Yes	9	0	1	0
R:R:G464	R:R:N463	1.7	0	No	Yes	7	9	2	1
R:R:L416	R:R:V419	1.49	0	Yes	No	9	7	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
73.33	Single	8GW8	KHF	8GW8-PTH1-KHF-Gs/β1/γ2
34.78	Single	8FN0	PubChem 118610427	8FN0-NTS₁-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
28.57	Single	8JPB	PubChem 118610427; GDP; Mg	8JPB-NTS₁-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
25.00	Single	8JPC	PubChem 118610427; GDP; Mg	8JPC-NTS₁-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
25.00	Single	8JPF	PubChem 118610427	8JPF-NTS₁-Neurotensin-PubChem 118610427
22.22	Single	5T1A	PubChem 68764898; PubChem 12093170	5T1A-CCR2-PubChem 68764898; PubChem 12093170
21.74	Single	5LWE	Vercirnon	5LWE-CCR9-Vercirnon
21.05	Single	8PJK	t7m	8PJK-5-HT_1A-ST171-t7m-Gi1/β1/γ1
20.00	Single	5XEZ	NNC0640	5XEZ-Glucagon-NNC0640
20.00	Single	6UO8	GS39783	6UO8-GABA_B1, GABA_B2-SKF97541-GS39783
19.05	Single	5XF1	NNC0640	5XF1-Glucagon-NNC0640
17.39	Single	8J20	AR420626	8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
16.67	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
16.67	Single	8TB7	PubChem 168510218	8TB7-GPR61-PubChem 168510218
16.00	Single	8JD3	HZR; PEF	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
15.79	Single	7CA3	rac-BHFF	7CA3-GABA_B1, GABA_B2-rac-BHFF
15.00	Single	5VEW	PF-06372222	5VEW-GLP-1-PF-06372222
15.00	Single	7C7Q	PubChem 7023848	7C7Q-GABA_B1, GABA_B2-Baclofen-PubChem 7023848
14.81	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
14.29	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
13.64	Single	6QZH	HY-133073; Na	6QZH-CCR7-HY-133073; Na
13.04	Single	6LFL	PubChem 153466996	6LFL-CXCR2-PubChem 153466996
12.50	Single	8ZPM	Cholesterol	8ZPM-CXCR4-AMD070-Cholesterol
11.54	Single	6LN2	PubChem 68178630	6LN2-GLP-1-PubChem 68178630
11.11	Single	7EB2	rac-BHFF	7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
11.11	Single	8PKM	t7m	8PKM-5-HT_1A-Befiradol-t7m-Gi1/β1/γ1
10.53	Single	8XQP	Aristolochic acid A	8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
10.00	Single	5VEX	NNC0640	5VEX-GLP-1-NNC0640
10.00	Single	6KK7	PubChem 68178630	6KK7-GLP-1-PubChem 68178630
9.52	Single	4K5Y	CP-376395	4K5Y-CRF₁-CP-376395
9.52	Single	6KJV	PubChem 68178630	6KJV-GLP-1-PubChem 68178630
9.52	Single	6KK1	PubChem 68178630	6KK1-GLP-1-PubChem 68178630
9.52	Single	8XQT	Cholesterol	8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
9.09	Single	5X7D	PubChem 129318963	5X7D-β₂-S-Carazolol-PubChem 129318963
8.70	Single	4Z9G	CP-376395	4Z9G-CRF₁-CP-376395
8.70	Single	8GTI	BMK-C205	8GTI-CRF₁-BMK-C205
8.70	Single	8XQL	Aristolochic acid A	8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
8.33	Single	8GTG	BMK-I152	8GTG-CRF₁-BMK-I152
7.69	Single	8GTM	BMK-C203	8GTM-CRF₁-BMK-C203
7.14	Single	6XBJ	Cholesterol	6XBJ-SMO-Cholesterol-Gi1/β1/γ2
7.14	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
5.88	Single	4PXF	Octyl-Beta-D-Glucopyranoside	4PXF-Rhodopsin-Octyl-β-D-Glucopyranoside-Arrestin1 Finger Loop
5.26	Single	8ZPN	Cholesterol	8ZPN-CXCR4-AMD3100-Cholesterol
5.00	Single	8Y69	Cholesterol	8Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
5.00	Single	8ZPL	Cholesterol	8ZPL-CXCR4-HF51116-Cholesterol
5.00	Single	8ZPM	Cholesterol	8ZPM-CXCR4-AMD070-Cholesterol
4.76	Single	8HNN	SCH546738	8HNN-CXCR3-SCH546738
4.76	Single	8Y69	Cholesterol	8Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
4.55	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
4.55	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
4.55	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.55	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.55	Single	8A6C	All-trans-Retinal	8A6C-Rhodopsin-All-trans-Retinal
4.55	Single	8A6D	All-trans-Retinal	8A6D-Rhodopsin-All-trans-Retinal
4.55	Single	8A6E	All-trans-Retinal	8A6E-Rhodopsin-All-trans-Retinal
4.55	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
4.55	Single	8XQN	Aristolochic acid A	8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
4.55	Single	8XQR	Flufenamic acid	8XQR-TAS2R14-Flufenamic acid-Gt3/β1/γ1
4.55	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.35	Single	3OAX	11-cis-Retinal	3OAX-Rhodopsin-11-cis-Retinal
4.35	Single	6A94	Zotepine	6A94-5-HT_2A-Zotepine
4.35	Single	7VOD	Cariprazine	7VOD-5-HT_2A-Cariprazine
4.35	Single	7ZBC	11-cis-Retinal	7ZBC-Rhodopsin-11-cis-Retinal
4.35	Single	7ZBE	11-cis-Retinal	7ZBE-Rhodopsin-11-cis-Retinal
4.35	Single	8RQL	Flufenamic acid	8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
4.35	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.35	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35	Single	8XQO	Aristolochic acid A	8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
4.35	Single	8XQS	Flufenamic acid	8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
4.35	Single	9ASB	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35	Single	9AVG	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.35	Consensus	5ht2a_off	Orthosteric Ligand	6A94-5-HT_2A-Zotepine 6A93-5-HT_2A-Risperidone 7VOD-5-HT_2A-Cariprazine 7WC8-5-HT_2A-Lumateperone 8JT8-5-HT_2A-(R)-IHCH-7179
4.17	Single	1HZX	11-cis-Retinal	1HZX-Rhodopsin-11-cis-Retinal
4.17	Single	6FKD	PubChem 137349183	6FKD-Rhodopsin-PubChem 137349183
4.17	Single	7F83	PF-05190457	7F83-Ghrelin-PF-05190457
4.17	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
4.17	Single	7RBT	PubChem 163183774	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
4.17	Single	7WC8	Lumateperone	7WC8-5-HT_2A-Lumateperone
4.17	Single	8JT8	(R)-IHCH-7179	8JT8-5-HT_2A-(R)-IHCH-7179
4.17	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
4.00	Single	6LUQ	Haloperidol	6LUQ-D₂-Haloperidol
4.00	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
4.00	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
4.00	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
4.00	Single	7VOE	Aripiprazole	7VOE-5-HT_2A-Aripiprazole
4.00	Single	8YNS	SNAP-94847	8YNS-MCH1-SNAP-94847
4.00	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
3.85	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
3.85	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
3.85	Single	8TAO	CDPPB	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.85	Single	8X0F	VU0424465	8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
3.85	Single	8YNT	SNAP-94847	8YNT-MCH1-SNAP-94847
3.70	Single	6A93	Risperidone	6A93-5-HT_2A-Risperidone
3.70	Single	6CM4	Risperidone	6CM4-D₂-Risperidone
3.70	Single	6XBL	Cholesterol	6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
3.57	Consensus	d2_off	Orthosteric Ligand	6CM4-D₂-Risperidone 6LUQ-D₂-Haloperidol 7DFP-D₂-Spiperone
3.45	Single	8IEI	A1LYA	8IEI-GPR156-A1LYA
3.33	Single	8IEB	A1LYA	8IEB-GPR156-A1LYA
3.33	Single	8IEI	A1LYA	8IEI-GPR156-A1LYA
3.33	Single	8IEP	A1LYA	8IEP-GPR156-A1LYA
3.33	Single	8IEP	A1LYA	8IEP-GPR156-A1LYA
3.23	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
3.23	Single	8IEB	A1LYA	8IEB-GPR156-A1LYA
3.03	Single	8IED	A1LYA	8IED-GPR156-A1LYA-Go/β1/γ2
3.03	Single	8IED	A1LYA	8IED-GPR156-A1LYA-Go/β1/γ2
2.86	Single	3VG9	Antibody	3VG9-A_2A-ZM-241385-Antibody
2.63	Single	3VGA	Antibody	3VGA-A_2A-ZM-241385-Antibody

PDB Summary
PDB	8JR9
Class	B1
SubFamily	Peptide
Type	Parathyroid Hormone
SubType	PTH1
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	PCO371
Protein Partners	chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution	2.57
Date	2023-08-02
D.O.I.	10.1038/s41586-023-06467-w

Net Summary
I_min	3.13
Number of Linked Nodes	821
Number of Links	982
Number of Hubs	149
Number of Links mediated by Hubs	558
Number of Communities	28
Number of Nodes involved in Communities	222
Number of Links involved in Communities	308

Path Summary
Number Of Nodes in MetaPath	130
Number Of Links MetaPath	129
Number of Shortest Paths	1866733
Length Of Smallest Path	3
Average Path Length	34.7469
Length of Longest Path	57
Minimum Path Strength	1.285
Average Path Strength	7.17418
Maximum Path Strength	40.21
Minimum Path Correlation	0.7
Average Path Correlation	0.980208
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.17391
Average % Of Corr. Nodes	37.924
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.6107
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • D1 dopamine receptor binding • molecular function activator activity • enzyme activator activity • cyclase activator activity • adenylate cyclase activator activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to nitrogen compound • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • adenylate cyclase-activating G protein-coupled receptor signaling pathway • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of multicellular organismal process • establishment of protein localization • nitrogen compound transport • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • regulation of hormone secretion • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • Golgi apparatus subcompartment • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • identical protein binding • protein homodimerization activity • protein dimerization activity • amide binding • peptide hormone binding • hormone binding • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • parathyroid hormone receptor activity • ossification • bone mineralization • biomineral tissue development • tissue development • skeletal system development • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • osteoblast development • cellular developmental process • cell differentiation • cell development • osteoblast differentiation • embryo development ending in birth or egg hatching • chordate embryonic development • embryo development • in utero embryonic development • anatomical structure maturation • cell maturation • developmental maturation • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • cell surface receptor signaling pathway • negative regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • connective tissue development • chondrocyte differentiation • cartilage development • regulation of inositol phosphate biosynthetic process • alcohol metabolic process • positive regulation of phosphate metabolic process • inositol phosphate metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • regulation of phosphate metabolic process • phosphate-containing compound metabolic process • polyol biosynthetic process • small molecule metabolic process • phosphorus metabolic process • regulation of carbohydrate metabolic process • regulation of biosynthetic process • carbohydrate metabolic process • polyol metabolic process • positive regulation of phosphorus metabolic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • carbohydrate biosynthetic process • primary metabolic process • positive regulation of inositol phosphate biosynthetic process • biosynthetic process • organophosphate metabolic process • organophosphate biosynthetic process • inositol phosphate biosynthetic process • alcohol biosynthetic process • regulation of phosphorus metabolic process • metabolic process • positive regulation of carbohydrate metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • tissue homeostasis • bone resorption • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • apical part of cell • plasma membrane region • apical plasma membrane • basal part of cell • basal plasma membrane • basolateral plasma membrane • receptor complex
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	KHF
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	KHF
Name	PCO-371
Synonyms	1-[3,5-dimethyl-4-[2-[[4-oxidanylidene-2-[4-(trifluoromethyloxy)phenyl]-1,3,8-triazaspiro[4.5]dec-1-en-8-yl]sulfonyl]ethyl]phenyl]-5,5-dimethyl-imidazolidine-2,4-dione
Identifier
Formula	C29 H32 F3 N5 O6 S
Molecular Weight	635.654
SMILES
PubChem	76283707
Formal Charge	0
Total Atoms	76
Total Chiral Atoms	0
Total Bonds	80
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	A
Protein	G Protein α Sub unit
UniProt	P63092
Sequence	>8JR9_Chain_A L S A E D K A A V E R S K M I E K Q L Q K D K Q V Y R A T H R L L L L G A D N S G K S T I V K Q M R I Y H V T S G I F E T K F Q V D K V N F H M F D V G A Q R D E R R K W I Q C F N D V T A I I F V V D S S D Y N R L Q E A L N D F K S I W N N R W L R T I S V I L F L N K Q D L L A E K V L A G K S K I E D Y F P E F A R Y T T P E D A T P E E D P R V T R A K Y F I R D E F L R I S T A S G D G R H Y C Y P H F T C S V D T E N A R R I F N D C R D I I Q R M H L R Q Y E L L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	B
Protein	G Protein β Sub unit
UniProt	P62873
Sequence	>8JR9_Chain_B E L D Q L R Q E A E Q L K N Q I R D A R K A C A D A T L S Q I T N N I D P V G R I Q M R T R R T L R G H L A K I Y A M H W G T D S R L L V S A S Q D G K L I I W D S Y T T N K V H A I P L R S S W V M T C A Y A P S G N Y V A C G G L D N I C S I Y N L K T R E G N V R V S R E L A G H T G Y L S C C R F L D D N Q I V T S S G D T T C A L W D I E T G Q Q T T T F T G H T G D V M S L S L A P D T R L F V S G A C D A S A K L W D V R E G M C R Q T F T G H E S D I N A I C F F P N G N A F A T G S D D A T C R L F D L R A D Q E L M T Y S H D N I I C G I T S V S F S K S G R L L L A G Y D D F N C N V W D A L K A D R A G V L A G H D N R V S C L G V T D D G M A V A T G S W D S F L K I W N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	G
Protein	G Protein γ Sub unit
UniProt	P59768
Sequence	>8JR9_Chain_G A S I A Q A R K L V E Q L K M E A N I D R I K V S K A A A D L M A Y C E A H A K E D P L L T P V P A S E N P F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	Q03431
Sequence	>8JR9_Chain_R D R L A M I Y T V G Y S V S L A S L T V A V L I L A Y F R R L H C T R N Y I H M H L F L S F M L R A V S I F V K D A V L A G Y A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M A F F S E K K Y L W G F T V F G W G L P A V F V A V W V S V R A T L A N T G C W D L S S G N K K W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L R E T N T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M A T P Y L W Q V Q M H Y E M L F N S F Q G F F V A I I Y C F C N G E V Q A E I K K S W S R W T L A L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9JR3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	To be published
	9JR3 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	To be published
	9JR2	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	To be published
	9JR2 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	To be published
	8JR9	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371	chim(NtGi1-Gs)/β1/γ2	2.57	2023-08-02	10.1038/s41586-023-06467-w
	8JR9 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371		2.57	2023-08-02	10.1038/s41586-023-06467-w
	7Y36	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Teriparatide	-	Gs/β1/γ2	2.8	2023-07-05	To be published
	7Y36 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Teriparatide	-		2.8	2023-07-05	To be published
	7Y35	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	2.9	2023-07-05	To be published
	7Y35 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		2.9	2023-07-05	To be published
	8GW8	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	KHF	Gs/β1/γ2	2.9	2023-06-14	10.1038/s41586-023-06169-3
	8GW8 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	KHF		2.9	2023-06-14	10.1038/s41586-023-06169-3
	8FLU	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-	Gs/β1/γ2	2.76	2023-04-26	10.1016/j.str.2023.04.002
	8FLU (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-		2.76	2023-04-26	10.1016/j.str.2023.04.002
	8FLT	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-	Gs/β1/γ2	3.03	2023-04-26	10.1016/j.str.2023.04.002
	8FLT (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-		3.03	2023-04-26	10.1016/j.str.2023.04.002
	8FLS	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	3.09	2023-04-26	10.1016/j.str.2023.04.002
	8FLS (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		3.09	2023-04-26	10.1016/j.str.2023.04.002
	8FLR	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	2.94	2023-04-26	10.1016/j.str.2023.04.002
	8FLR (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		2.94	2023-04-26	10.1016/j.str.2023.04.002
	8FLQ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.55	2023-04-26	10.1016/j.str.2023.04.002
	8FLQ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.55	2023-04-26	10.1016/j.str.2023.04.002
	8HAO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	3.76	2022-12-21	10.1038/s41401-022-01032-z
	8HAO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.76	2022-12-21	10.1038/s41401-022-01032-z
	8HAF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	chim(NtGi1-Gs)/β1/γ2	3.25	2022-12-21	10.1038/s41401-022-01032-z
	8HAF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.25	2022-12-21	10.1038/s41401-022-01032-z
	8HA0	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	2.62	2022-12-21	10.1038/s41401-022-01032-z
	8HA0 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.62	2022-12-21	10.1038/s41401-022-01032-z
	7VVO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	4.1	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		4.1	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVN	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVN (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVM	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVM (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVL	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVL (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVK	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.3	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVK (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.3	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVJ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVJ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	6NBI	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	4	2019-04-17	10.1126/science.aav7942
	6NBI (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		4	2019-04-17	10.1126/science.aav7942
	6NBH	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	3.5	2019-04-17	10.1126/science.aav7942
	6NBH (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		3.5	2019-04-17	10.1126/science.aav7942
	6NBF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	3	2019-04-17	10.1126/science.aav7942
	6NBF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		3	2019-04-17	10.1126/science.aav7942
	6FJ3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	-	2.5	2018-11-21	10.1038/s41594-018-0151-4

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