Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:C108 3.76429
2R:R:W112 6.6475467
3R:R:I115 4.382525
4R:R:L116 3.5525425
5R:R:W118 7.07286729
6R:R:P132 4.155429
7R:R:I135 8.11427
8R:R:F138 7.94524
9R:R:Y145 4.4675404
10R:R:R146 8.04333628
11R:R:W154 7.185429
12R:R:V157 3.5525404
13R:R:Y167 3.72143725
14R:R:Y191 2.8475407
15R:R:Y195 7.13417
16R:R:L202 3.955409
17R:R:F212 4.61607
18R:R:F227 4.036589
19R:R:F230 6.1175408
20R:R:R233 7.90333618
21R:R:K240 7.28517
22R:R:Y290 5.6275449
23R:R:F291 9.915445
24R:R:L292 4.41516
25R:R:T294 5.205448
26R:R:Y296 7.6075417
27R:R:W298 9.934549
28R:R:E302 8.4575409
29R:R:Y305 8.205408
30R:R:H307 7.085438
31R:R:F311 5.975436
32R:R:F327 2.848505
33R:R:W329 6.464549
34R:R:P332 3.9409
35R:R:W339 5.2475458
36R:R:V342 2.71455
37R:R:W352 15.8675408
38R:R:L354 3.5625405
39R:R:Q364 5.674517
40R:R:F378 5.594539
41R:R:I381 3.41439
42R:R:F417 6.25143739
43R:R:H420 6.998518
44R:R:Y421 10.932518
45R:R:F424 7.6425417
46R:R:M425 3.715406
47R:R:W437 3.88143715
48R:R:Q438 2.8275414
49R:R:M441 5.634516
50R:R:E444 5.6475417
51R:R:M445 3.828516
52R:R:N448 5.51416
53R:R:F450 4.3625477
54R:R:F453 5.0175406
55L:L:V2 6.17410
56L:L:E4 6.856510
57L:L:I5 5.0925410
58L:L:Q6 6.7175410
59L:L:M8 6.202510
60L:L:R20 8.1425420
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:E36 R:R:T33 84.14087.06NoNo067
2R:R:L354 R:R:T33 88.23121.47YesNo057
3R:R:E36 R:R:M32 83.31672.71NoNo066
4L:L:R20 R:R:M32 81.65734.96YesNo006
5L:L:R20 R:R:D137 79.07314.29YesNo205
6L:L:L24 R:R:D137 78.32054.07NoNo205
7L:L:L24 R:R:F138 75.64538.53NoYes204
8R:R:F138 R:R:I135 14.923120.09YesYes247
9R:R:A44 R:R:Y134 22.96574NoNo075
10R:R:P132 R:R:Y134 12.70994.17YesNo295
11R:R:F138 R:R:P132 54.06165.78YesYes249
12R:R:I135 R:R:Y134 12.16024.84YesNo275
13R:R:A44 R:R:W112 21.09853.89NoYes077
14R:R:C48 R:R:W112 13.45039.14NoYes687
15R:R:C48 R:R:L52 11.54083.17NoNo084
16R:R:L116 R:R:W118 17.19984.56YesYes259
17R:R:L116 R:R:P132 41.74813.28YesYes259
18R:R:L116 R:R:Y167 19.95763.52YesYes255
19L:L:H32 R:R:Y167 14.61343.27NoYes005
20L:L:H32 R:R:N166 13.64912.55NoNo007
21R:R:N166 R:R:Y145 11.72048.14NoYes074
22L:L:A12 R:R:L354 93.8733.15NoYes005
23L:L:A12 R:R:D353 94.67096.18NoNo005
24R:R:D353 R:R:K240 37.27144.15NoYes157
25R:R:F288 R:R:K240 43.850314.89NoYes177
26R:R:F288 R:R:I237 86.7082.51NoNo177
27L:L:E4 R:R:I237 46.29444.1YesNo107
28L:L:E4 R:R:M445 11.42684.06YesYes106
29L:L:M8 R:R:D353 58.19446.93YesNo105
30L:L:M8 R:R:F288 42.78318.71YesNo107
31R:R:I237 R:R:Y195 40.51558.46NoYes177
32R:R:F453 R:R:S201 26.03622.64YesNo068
33R:R:A456 R:R:S201 26.9383.42NoNo088
34R:R:A456 R:R:L202 27.83783.15NoYes089
35R:R:F230 R:R:L202 33.28593.65YesYes089
36R:R:F230 R:R:N295 76.91738.46YesNo088
37R:R:N295 R:R:R233 1009.64NoYes088
38R:R:R233 R:R:Y195 39.8898.23YesYes187
39L:L:E4 R:R:R233 42.380611.63YesYes108
40R:R:L292 R:R:R233 21.10056.07YesYes168
41L:L:I5 R:R:L292 21.2772.85YesYes106
42L:L:H9 L:L:I5 27.03692.65NoYes000
43L:L:H9 L:L:M8 26.83116.57NoYes000
44R:R:T294 R:R:W329 13.60278.49YesYes489
45R:R:S229 R:R:W329 25.52882.47NoYes099
46R:R:N295 R:R:S229 26.32475.96NoNo089
47R:R:F230 R:R:L226 45.28179.74YesNo089
48R:R:I208 R:R:V204 15.98333.07NoNo085
49R:R:F461 R:R:V204 16.90722.62NoNo085
50R:R:F461 R:R:I457 17.82923.77NoNo086
51R:R:F453 R:R:I457 19.667110.05YesNo066
52R:R:F212 R:R:I208 15.05722.51YesNo078
53R:R:W298 R:R:W329 10.194218.74YesYes499
54R:R:E302 R:R:L226 41.96515.9YesNo099
55R:R:K240 R:R:V285 11.25034.55YesNo176
56L:L:M8 R:R:V285 16.39083.04YesNo106
57R:R:C281 R:R:V285 26.60411.71NoNo096
58R:R:C281 R:R:C351 25.56417.28NoNo099
59R:R:A276 R:R:C351 24.52211.81NoNo049
60R:R:A276 R:R:G350 23.47811.95NoNo045
61R:R:G350 R:R:T349 22.4321.82NoNo055
62R:R:A347 R:R:T349 21.3841.68NoNo075
63R:R:A347 R:R:R343 18.22772.77NoNo078
64R:R:R343 R:R:W352 17.171520.99NoYes088
65R:R:V340 R:R:W352 12.92684.9NoYes058
66R:R:V340 R:R:W339 10.79242.45NoYes058
67R:R:F417 R:R:L416 32.46387.31YesNo099
68R:R:E302 R:R:L416 35.54343.98YesNo099
69R:R:F378 R:R:V419 10.24069.18YesNo397
70R:R:F378 R:R:F417 22.27177.5YesYes399
71R:R:F378 R:R:M414 10.24062.49YesNo398
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L354 R:R:V31 2.98 0 Yes No 5 6 1 1
L:L:K13 R:R:V31 6.07 0 No No 0 6 0 1
R:R:E36 R:R:M32 2.71 0 No No 6 6 2 1
L:L:R20 R:R:M32 4.96 2 Yes No 0 6 0 1
R:R:E35 R:R:T33 5.64 0 No No 5 7 2 2
R:R:E36 R:R:T33 7.06 0 No No 6 7 2 2
L:L:F23 R:R:K34 8.69 0 No No 0 4 0 1
R:R:H114 R:R:I115 5.3 2 No Yes 4 5 1 1
L:L:L27 R:R:H114 7.71 2 No No 0 4 0 1
L:L:I31 R:R:H114 3.98 2 No No 0 4 0 1
R:R:I115 R:R:L116 2.85 2 Yes Yes 5 5 1 2
R:R:I115 R:R:Y167 3.63 2 Yes Yes 5 5 1 1
L:L:L27 R:R:I115 5.71 2 No Yes 0 5 0 1
L:L:I31 R:R:I115 4.42 2 No Yes 0 5 0 1
R:R:L116 R:R:P132 3.28 2 Yes Yes 5 9 2 2
R:R:L116 R:R:Y167 3.52 2 Yes Yes 5 5 2 1
R:R:I135 R:R:P132 3.39 2 Yes Yes 7 9 2 2
R:R:F138 R:R:P132 5.78 2 Yes Yes 4 9 1 2
R:R:F138 R:R:I135 20.09 2 Yes Yes 4 7 1 2
R:R:D137 R:R:Y136 4.6 2 No No 5 4 1 1
L:L:R20 R:R:Y136 6.17 2 Yes No 0 4 0 1
L:L:R20 R:R:D137 14.29 2 Yes No 0 5 0 1
L:L:L24 R:R:D137 4.07 2 No No 0 5 0 1
R:R:C170 R:R:F138 2.79 0 No Yes 9 4 2 1
L:L:L24 R:R:F138 8.53 2 No Yes 0 4 0 1
L:L:I28 R:R:F138 2.51 2 No Yes 0 4 0 1
R:R:A144 R:R:Y167 4 0 No Yes 7 5 2 1
R:R:N166 R:R:Y145 8.14 0 No Yes 7 4 1 2
R:R:A165 R:R:R146 4.15 2 No Yes 7 8 2 2
R:R:R146 R:R:Y167 4.12 2 Yes Yes 8 5 2 1
R:R:E155 R:R:W164 8.72 0 No No 4 5 2 1
R:R:V157 R:R:W164 2.45 0 Yes No 4 5 2 1
L:L:E30 R:R:R162 4.65 0 No No 0 3 0 1
L:L:T33 R:R:W164 8.49 0 No No 0 5 0 1
R:R:A165 R:R:Y167 2.67 2 No Yes 7 5 2 1
R:R:N166 R:R:S168 5.96 0 No No 7 6 1 2
L:L:H32 R:R:N166 2.55 0 No No 0 7 0 1
L:L:I31 R:R:Y167 4.84 2 No Yes 0 5 0 1
L:L:H32 R:R:Y167 3.27 0 No Yes 0 5 0 1
L:L:I28 R:R:V171 4.61 2 No No 0 3 0 1
L:L:R21 R:R:L174 13.36 0 No No 0 3 0 1
L:L:H25 R:R:L174 3.86 0 No No 0 3 0 1
L:L:W14 R:R:E180 7.63 0 No No 0 3 0 1
R:R:D185 R:R:R181 3.57 0 No No 2 3 2 1
L:L:W14 R:R:R181 3 0 No No 0 3 0 1
R:R:V183 R:R:W437 2.45 1 No Yes 4 5 2 1
R:R:Q438 R:R:V183 2.87 1 Yes No 4 4 2 2
R:R:F184 R:R:W437 3.01 0 No Yes 6 5 1 1
L:L:L7 R:R:F184 2.44 1 No No 0 6 0 1
L:L:W14 R:R:F184 12.03 0 No No 0 6 0 1
R:R:L187 R:R:W437 3.42 1 No Yes 5 5 2 1
R:R:L187 R:R:M441 7.07 1 No Yes 5 6 2 1
R:R:I190 R:R:M445 2.92 0 No Yes 6 6 2 1
R:R:Y191 R:R:Y195 3.97 0 Yes Yes 7 7 2 1
R:R:M445 R:R:Y191 3.59 1 Yes Yes 6 7 1 2
R:R:R233 R:R:Y195 8.23 1 Yes Yes 8 7 1 1
R:R:I237 R:R:Y195 8.46 1 No Yes 7 7 1 1
L:L:E4 R:R:Y195 7.86 1 Yes Yes 0 7 0 1
R:R:L292 R:R:R233 6.07 1 Yes Yes 6 8 1 1
R:R:N295 R:R:R233 9.64 0 No Yes 8 8 2 1
R:R:R233 R:R:Y296 8.23 1 Yes Yes 8 7 1 1
R:R:N448 R:R:R233 3.62 1 Yes Yes 6 8 2 1
L:L:E4 R:R:R233 11.63 1 Yes Yes 0 8 0 1
R:R:F288 R:R:I237 2.51 1 No No 7 7 1 1
L:L:E4 R:R:I237 4.1 1 Yes No 0 7 0 1
R:R:K240 R:R:L244 7.05 1 Yes No 7 5 1 1
R:R:K240 R:R:V285 4.55 1 Yes No 7 6 1 1
R:R:F288 R:R:K240 14.89 1 No Yes 7 7 1 1
R:R:D353 R:R:K240 4.15 1 No Yes 5 7 1 1
L:L:M8 R:R:K240 5.76 1 Yes Yes 0 7 0 1
L:L:R11 R:R:L244 10.93 0 No No 0 5 0 1
L:L:M8 R:R:V285 3.04 1 Yes No 0 6 0 1
L:L:M8 R:R:F288 8.71 1 Yes No 0 7 0 1
R:R:L292 R:R:Y296 3.52 1 Yes Yes 6 7 1 1
L:L:V2 R:R:L292 2.98 1 Yes Yes 0 6 0 1
L:L:E4 R:R:L292 6.63 1 Yes Yes 0 6 0 1
L:L:I5 R:R:L292 2.85 1 Yes Yes 0 6 0 1
R:R:Y296 R:R:Y421 14.89 1 Yes Yes 7 8 1 2
L:L:V2 R:R:Y296 3.79 1 Yes Yes 0 7 0 1
L:L:M8 R:R:D353 6.93 1 Yes No 0 5 0 1
L:L:A12 R:R:D353 6.18 0 No No 0 5 0 1
L:L:A12 R:R:L354 3.15 0 No Yes 0 5 0 1
L:L:Q16 R:R:L354 6.65 0 No Yes 0 5 0 1
L:L:H9 R:R:S355 5.58 0 No No 0 7 0 1
R:R:K360 R:R:W361 9.28 0 No No 7 8 2 2
R:R:K360 R:R:Y429 5.97 0 No No 7 6 2 1
R:R:Q364 R:R:W361 4.38 1 Yes No 7 8 1 2
R:R:L368 R:R:Q364 6.65 0 No Yes 4 7 2 1
L:L:A1 R:R:Q364 6.06 0 No Yes 0 7 0 1
L:L:V2 R:R:Q364 7.16 1 Yes Yes 0 7 0 1
L:L:I5 R:R:Q364 4.12 1 Yes Yes 0 7 0 1
R:R:N448 R:R:Y421 9.3 1 Yes Yes 6 8 2 2
R:R:F424 R:R:Q440 10.54 1 Yes No 7 6 2 1
R:R:F424 R:R:Y443 5.16 1 Yes No 7 4 2 2
R:R:E444 R:R:F424 7 1 Yes Yes 7 7 1 2
R:R:Q440 R:R:T427 12.76 0 No No 6 5 1 2
L:L:A1 R:R:Y429 2.67 0 No No 0 6 0 1
L:L:Q6 R:R:Y429 14.65 1 Yes No 0 6 0 1
R:R:T430 R:R:W437 3.64 0 No Yes 5 5 2 1
L:L:Q10 R:R:V432 2.87 0 No No 0 5 0 1
R:R:Q438 R:R:W437 3.29 1 Yes Yes 4 5 2 1
R:R:M441 R:R:W437 6.98 1 Yes Yes 6 5 1 1
L:L:Q6 R:R:W437 4.38 1 Yes Yes 0 5 0 1
L:L:Q6 R:R:Q440 5.12 1 Yes No 0 6 0 1
R:R:M441 R:R:M445 4.33 1 Yes Yes 6 6 1 1
L:L:Q6 R:R:M441 2.72 1 Yes Yes 0 6 0 1
L:L:L7 R:R:M441 7.07 1 No Yes 0 6 0 1
R:R:E444 R:R:Y443 4.49 1 Yes No 7 4 1 2
R:R:E444 R:R:N448 6.57 1 Yes Yes 7 6 1 2
L:L:A3 R:R:E444 4.53 0 No Yes 0 7 0 1
L:L:E4 R:R:M445 4.06 1 Yes Yes 0 6 0 1
L:L:L7 R:R:M445 4.24 1 No Yes 0 6 0 1
L:L:R21 R:R:E177 2.33 0 No No 0 1 0 1
R:R:C281 R:R:V285 1.71 0 No No 9 6 2 1
R:R:L354 R:R:T33 1.47 0 Yes No 5 7 1 2
R:R:L40 R:R:M32 1.41 0 No No 5 6 2 1
R:R:E35 R:R:K34 1.35 0 No No 5 4 2 1
R:R:R162 R:R:V157 1.31 0 No Yes 3 4 1 2
R:R:F173 R:R:L174 1.22 0 No No 3 3 2 1
R:R:E180 R:R:R179 1.16 0 No No 3 3 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 6NBH_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.44
Number of Linked Nodes 361
Number of Links 404
Number of Hubs 60
Number of Links mediated by Hubs 221
Number of Communities 8
Number of Nodes involved in Communities 84
Number of Links involved in Communities 119
Path Summary
Number Of Nodes in MetaPath 72
Number Of Links MetaPath 71
Number of Shortest Paths 151301
Length Of Smallest Path 3
Average Path Length 21.5452
Length of Longest Path 44
Minimum Path Strength 1.155
Average Path Strength 5.95022
Maximum Path Strength 27.99
Minimum Path Correlation 0.7
Average Path Correlation 0.957027
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.33333
Average % Of Corr. Nodes 57.6153
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 40.5211
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• identical protein binding   • protein binding   • binding   • protein homodimerization activity   • protein dimerization activity   • amide binding   • peptide hormone binding   • hormone binding   • peptide receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • G protein-coupled peptide receptor activity   • signaling receptor activity   • transmembrane signaling receptor activity   • parathyroid hormone receptor activity   • developmental process   • multicellular organismal process   • ossification   • bone mineralization   • animal organ development   • anatomical structure development   • biomineral tissue development   • tissue development   • multicellular organism development   • skeletal system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus
Gene OntologyBiological Process• developmental process   • multicellular organismal process   • ossification   • bone mineralization   • animal organ development   • anatomical structure development   • biomineral tissue development   • tissue development   • multicellular organism development   • skeletal system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • inorganic ion homeostasis   • intracellular calcium ion homeostasis   • homeostatic process   • calcium ion homeostasis   • cellular homeostasis   • chemical homeostasis   • intracellular monoatomic cation homeostasis   • monoatomic ion homeostasis   • intracellular chemical homeostasis   • monoatomic cation homeostasis   • intracellular monoatomic ion homeostasis   • osteoblast development   • cellular developmental process   • cell differentiation   • cell development   • osteoblast differentiation   • embryo development ending in birth or egg hatching   • chordate embryonic development   • embryo development   • in utero embryonic development   • anatomical structure maturation   • cell maturation   • developmental maturation   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • positive regulation of cell population proliferation   • regulation of cell population proliferation   • positive regulation of biological process   • positive regulation of cellular process   • cell surface receptor signaling pathway   • negative regulation of cell population proliferation   • negative regulation of cellular process   • negative regulation of biological process   • phospholipase C-activating G protein-coupled receptor signaling pathway   • connective tissue development   • chondrocyte differentiation   • cartilage development   • regulation of inositol phosphate biosynthetic process   • alcohol metabolic process   • positive regulation of phosphate metabolic process   • inositol phosphate metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • phosphate-containing compound metabolic process   • polyol biosynthetic process   • small molecule metabolic process   • phosphorus metabolic process   • regulation of carbohydrate metabolic process   • regulation of biosynthetic process   • carbohydrate metabolic process   • polyol metabolic process   • positive regulation of phosphorus metabolic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • carbohydrate biosynthetic process   • primary metabolic process   • positive regulation of inositol phosphate biosynthetic process   • biosynthetic process   • organophosphate metabolic process   • organophosphate biosynthetic process   • inositol phosphate biosynthetic process   • alcohol biosynthetic process   • metabolic process   • regulation of phosphorus metabolic process   • positive regulation of carbohydrate metabolic process   • regulation of carbohydrate biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • multicellular organismal-level homeostasis   • tissue remodeling   • bone remodeling   • anatomical structure homeostasis   • tissue homeostasis   • bone resorption   • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • cellular anatomical structure   • organelle lumen   • organelle   • membraneless organelle   • nuclear lumen
Gene OntologyCellular Component• membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • cellular anatomical structure   • organelle lumen   • organelle   • membraneless organelle   • nuclear lumen   • cell periphery   • apical part of cell   • membrane   • plasma membrane   • plasma membrane region   • apical plasma membrane   • cytoplasm   • cytosol   • basal part of cell   • basal plasma membrane   • basolateral plasma membrane   • protein-containing complex   • receptor complex   • peptide hormone receptor binding   • protein binding   • binding   • corticotropin-releasing hormone receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • corticotropin-releasing hormone receptor 1 binding   • hormone receptor binding   • neuropeptide receptor binding   • mu-type opioid receptor binding   • opioid receptor binding   • beta-2 adrenergic receptor binding   • adrenergic receptor binding   • D1 dopamine receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • ionotropic glutamate receptor binding   • glutamate receptor binding   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • molecular function regulator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • metal ion binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • insulin-like growth factor receptor binding   • magnesium ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to oxygen-containing compound   • response to nitrogen compound   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • regulation of protein localization   • positive regulation of biological process   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • localization   • regulation of protein localization to cell cortex   • macromolecule localization   • positive regulation of protein localization   • intracellular protein localization   • protein localization to cell cortex   • cell division   • response to ketone   • response to lipid   • response to alcohol   • cellular response to forskolin   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • midbody   • cell cortex   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • cytoskeletal protein binding   • spectrin binding   • enzyme binding   • GTPase binding   • phosphoric ester hydrolase activity   • alkylglycerophosphoethanolamine phosphodiesterase activity   • hydrolase activity, acting on ester bonds   • phosphoric diester hydrolase activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • positive regulation of cytosolic calcium ion concentration   • regulation of biological quality   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • response to decreased oxygen levels   • cellular response to oxygen levels   • cellular response to hypoxia   • cellular response to decreased oxygen levels   • cellular response to stress   • response to hypoxia   • response to stress   • response to oxygen levels   • response to abiotic stimulus   • cell population proliferation   • phospholipase C-activating G protein-coupled receptor signaling pathway   • muscle cell apoptotic process   • striated muscle cell apoptotic process   • apoptotic process   • cell death   • programmed cell death   • cardiac muscle cell apoptotic process   • photoreceptor inner segment   • somatodendritic compartment   • cell projection   • dendrite   • dendritic tree   • neuron projection   • plasma membrane bounded cell projection   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • photoreceptor outer segment   • photoreceptor cell cilium   • ciliary membrane   • photoreceptor outer segment membrane   • bounding membrane of organelle   • organelle membrane   • cell projection membrane   • synapse   • cell junction   • cell body   • G-protein beta-subunit binding   • response to prostaglandin   • response to endogenous stimulus   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • response to hormone   • response to prostaglandin E   • cellular response to hormone stimulus
SCOP2Domain Identifier• G protein-coupled receptor-like   • Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• G protein-coupled receptor-like   • Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ03431
Sequence
>6NBH_nogp_Chain_R
VMTKEEQIF LLHRAQAQC EKRLKEVLG RPCLPEWDH ILCWPLGAP 
GEVVAVPCP DYIYDFNHK GHAYRRCDR NGSWELVPG HNRTWANYS 
ECVKFLTNE TREREVFDR LAMIYTVGY SVSLASLTV AVLILAYFR 
RLHCTRNYI HMHLFLSFM LRAVSIFVK DAVLYSGAT LTAAAGYAG 
CRVAVTFFL YFLATNYYW ILVEGLYLH SLIFMAFFS EKKYLWGFT 
VFGWGLPAV FVAVWVSVR ATLANTGCW DLSSGNKKW IIQVPILAS 
IVLNFILFI NIVRVLATK LRETNATRQ QYRKLLKST LVLMPLFGV 
HYIVFMATP YTEVSGTLW QVQMHYEML FNSFQGFFV AIIYCFCNG 
EVQAEIKKS WSRWTLALD F


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8GW8B1PeptideParathyroid HormonePTH1Homo sapiens-PCO371Gs/β1/γ22.92023-06-14doi.org/10.1038/s41586-023-06169-3
8GW8 (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiens-PCO3712.92023-06-14doi.org/10.1038/s41586-023-06169-3
8JR9B1PeptideParathyroid HormonePTH1Homo sapiens-PCO371chim(NtGi1-Gs)/β1/γ22.572023-08-02doi.org/10.1038/s41586-023-06467-w
8JR9 (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiens-PCO3712.572023-08-02doi.org/10.1038/s41586-023-06467-w
7VVJB1PeptideParathyroid HormonePTH1Homo sapiensPTHrP(1-36)-Gs/β1/γ23.22022-08-03doi.org/10.1016/j.molcel.2022.07.003
7VVJ (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTHrP(1-36)-3.22022-08-03doi.org/10.1016/j.molcel.2022.07.003
7VVKB1PeptideParathyroid HormonePTH1Homo sapiensPTH-Gs/β1/γ23.32022-08-03doi.org/10.1016/j.molcel.2022.07.003
7VVK (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTH-3.32022-08-03doi.org/10.1016/j.molcel.2022.07.003
7VVLB1PeptideParathyroid HormonePTH1Homo sapiensPTH-Gs/β1/γ22.82022-08-03doi.org/10.1016/j.molcel.2022.07.003
7VVL (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTH-2.82022-08-03doi.org/10.1016/j.molcel.2022.07.003
7VVMB1PeptideParathyroid HormonePTH1Homo sapiensPTH-Gs/β1/γ23.22022-08-03doi.org/10.1016/j.molcel.2022.07.003
7VVM (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTH-3.22022-08-03doi.org/10.1016/j.molcel.2022.07.003
7VVNB1PeptideParathyroid HormonePTH1Homo sapiensPTH-Gs/β1/γ23.82022-08-03doi.org/10.1016/j.molcel.2022.07.003
7VVN (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTH-3.82022-08-03doi.org/10.1016/j.molcel.2022.07.003
7VVOB1PeptideParathyroid HormonePTH1Homo sapiensPTH-Gs/β1/γ24.12022-08-03doi.org/10.1016/j.molcel.2022.07.003
7VVO (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTH-4.12022-08-03doi.org/10.1016/j.molcel.2022.07.003
8FLQB1PeptideParathyroid HormonePTH1Homo sapiensPTH-Gs/β1/γ22.552023-04-26doi.org/10.1016/j.str.2023.04.002
8FLQ (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTH-2.552023-04-26doi.org/10.1016/j.str.2023.04.002
8FLRB1PeptideParathyroid HormonePTH1Homo sapiensPTHrP(1-36)-Gs/β1/γ22.942023-04-26doi.org/10.1016/j.str.2023.04.002
8FLR (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTHrP(1-36)-2.942023-04-26doi.org/10.1016/j.str.2023.04.002
8FLSB1PeptideParathyroid HormonePTH1Homo sapiensAbaloparatide-Gs/β1/γ23.092023-04-26doi.org/10.1016/j.str.2023.04.002
8FLS (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensAbaloparatide-3.092023-04-26doi.org/10.1016/j.str.2023.04.002
8FLTB1PeptideParathyroid HormonePTH1Homo sapiensM-PTH(1-14)-Gs/β1/γ23.032023-04-26doi.org/10.1016/j.str.2023.04.002
8FLT (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensM-PTH(1-14)-3.032023-04-26doi.org/10.1016/j.str.2023.04.002
8FLUB1PeptideParathyroid HormonePTH1Homo sapiensLong-Acting PTH-Gs/β1/γ22.762023-04-26doi.org/10.1016/j.str.2023.04.002
8FLU (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensLong-Acting PTH-2.762023-04-26doi.org/10.1016/j.str.2023.04.002
8HA0B1PeptideParathyroid HormonePTH1Homo sapiensPTH-chim(NtGi1-Gs)/β1/γ22.622022-12-21doi.org/10.1038/s41401-022-01032-z
8HA0 (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTH-2.622022-12-21doi.org/10.1038/s41401-022-01032-z
8HAFB1PeptideParathyroid HormonePTH1Homo sapiensPTHrP(1-36)-chim(NtGi1-Gs)/β1/γ23.252022-12-21doi.org/10.1038/s41401-022-01032-z
8HAF (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTHrP(1-36)-3.252022-12-21doi.org/10.1038/s41401-022-01032-z
8HAOB1PeptideParathyroid HormonePTH1Homo sapiensPTH-chim(NtGi1-Gs)/β1/γ23.762022-12-21doi.org/10.1038/s41401-022-01032-z
8HAO (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTH-3.762022-12-21doi.org/10.1038/s41401-022-01032-z
6FJ3B1PeptideParathyroid HormonePTH1Homo sapiensPTH--2.52018-11-21doi.org/10.1038/s41594-018-0151-4
6NBFB1PeptideParathyroid HormonePTH1Homo sapiensLong-Acting PTH Analog-Gs/β1/γ232019-04-17doi.org/10.1126/science.aav7942
6NBF (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensLong-Acting PTH Analog-32019-04-17doi.org/10.1126/science.aav7942
6NBHB1PeptideParathyroid HormonePTH1Homo sapiensLong-Acting PTH Analog-Gs/β1/γ23.52019-04-17doi.org/10.1126/science.aav7942
6NBH (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensLong-Acting PTH Analog-3.52019-04-17doi.org/10.1126/science.aav7942
6NBIB1PeptideParathyroid HormonePTH1Homo sapiensLong-Acting PTH Analog-Gs/β1/γ242019-04-17doi.org/10.1126/science.aav7942
6NBI (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensLong-Acting PTH Analog-42019-04-17doi.org/10.1126/science.aav7942
9B5YB1PeptideParathyroid HormonePTH1Homo sapiensLong-Acting PTH-chim(NtGi1-Gq)/β1/γ23.492025-03-19doi.org/10.1073/pnas.2426178122
9B5Y (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensLong-Acting PTH-3.492025-03-19doi.org/10.1073/pnas.2426178122
7Y35B1PeptideParathyroid HormonePTH1Homo sapiensAbaloparatide-Gs/β1/γ22.92023-07-05To be published
7Y35 (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensAbaloparatide-2.92023-07-05To be published
7Y36B1PeptideParathyroid HormonePTH1Homo sapiensTeriparatide-Gs/β1/γ22.82023-07-05To be published
7Y36 (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensTeriparatide-2.82023-07-05To be published
9JR2B1PeptideParathyroid HormonePTH1Homo sapiensPTH-chim(NtGi1L-Gs-CtGq)/β1/γ22.82024-10-16To be published
9JR2 (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTH-2.82024-10-16To be published
9JR3B1PeptideParathyroid HormonePTH1Homo sapiensPTH-chim(NtGi1L-Gs-CtGq)/β1/γ22.82024-10-16To be published
9JR3 (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTH-2.82024-10-16To be published




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Download 6NBH_nogp.zip



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