psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:K13	R:R:V31	9.11	No	No	0	0	6
2	R:R:M32	R:R:Y136	3.59	No	No	0	6	4
3	R:R:E36	R:R:T33	7.06	No	No	0	6	7
4	L:L:F23	R:R:K34	4.96	No	No	0	0	4
5	R:R:L41	R:R:Q37	5.32	No	No	0	8	7
6	R:R:I135	R:R:Q37	4.12	Yes	No	0	7	7
7	R:R:A44	R:R:W112	3.89	No	Yes	0	7	7
8	R:R:A44	R:R:Y134	5.34	No	Yes	0	7	5
9	R:R:Q45	R:R:W112	16.43	No	Yes	0	7	7
10	R:R:K50	R:R:Q47	4.07	No	No	0	4	6
11	R:R:C48	R:R:W112	9.14	No	Yes	0	8	7
12	R:R:C117	R:R:C48	7.28	No	No	0	9	8
13	R:R:E54	R:R:R51	5.82	No	No	0	6	6
14	R:R:L52	R:R:P110	3.28	No	Yes	0	4	6
15	R:R:P110	R:R:V55	3.53	Yes	No	6	6	5
16	R:R:L120	R:R:V55	4.47	No	No	6	4	5
17	R:R:C108	R:R:C148	7.28	No	No	0	9	9
18	R:R:C108	R:R:W154	14.37	No	No	0	9	9
19	R:R:L109	R:R:P110	3.28	No	Yes	0	5	6
20	R:R:L120	R:R:P110	3.28	No	Yes	6	4	6
21	R:R:E111	R:R:R146	5.82	No	Yes	2	7	8
22	R:R:E111	R:R:W154	18.54	No	No	2	7	9
23	R:R:H114	R:R:W112	3.17	No	Yes	0	4	7
24	R:R:D113	R:R:W118	11.17	No	Yes	2	9	9
25	R:R:D113	R:R:R146	10.72	No	Yes	2	9	8
26	R:R:D113	R:R:Y167	4.6	No	Yes	2	9	5
27	L:L:L27	R:R:I115	7.14	No	No	0	0	5
28	L:L:I31	R:R:I115	5.89	No	No	0	0	5
29	R:R:L116	R:R:W118	4.56	No	Yes	0	5	9
30	R:R:L116	R:R:P132	9.85	No	No	0	5	9
31	R:R:V129	R:R:W118	7.36	No	Yes	0	5	9
32	R:R:R146	R:R:W118	27.99	Yes	Yes	2	8	9
33	R:R:W118	R:R:Y167	5.79	Yes	Yes	2	9	5
34	R:R:P119	R:R:V127	3.53	No	No	0	6	7
35	R:R:P119	R:R:V129	3.53	No	No	0	6	5
36	R:R:C148	R:R:G121	3.92	No	No	0	9	7
37	R:R:V126	R:R:Y145	3.79	No	No	0	4	4
38	R:R:R147	R:R:V126	3.92	No	No	0	3	4
39	R:R:P130	R:R:V129	3.53	No	No	0	5	5
40	R:R:H143	R:R:P130	9.15	No	No	0	3	5
41	R:R:C131	R:R:C170	7.28	No	No	0	9	9
42	R:R:P132	R:R:Y134	4.17	No	Yes	5	9	5
43	R:R:I135	R:R:P132	5.08	Yes	No	5	7	9
44	R:R:D133	R:R:H140	8.82	No	No	0	2	3
45	R:R:I135	R:R:Y134	4.84	Yes	Yes	5	7	5
46	R:R:F138	R:R:I135	16.33	Yes	Yes	0	4	7
47	R:R:D137	R:R:Y136	4.6	No	No	4	5	4
48	L:L:R20	R:R:Y136	7.2	No	No	4	0	4
49	L:L:R20	R:R:D137	3.57	No	No	4	0	5
50	L:L:R21	R:R:D137	9.53	No	No	0	0	5
51	R:R:F138	R:R:V171	3.93	Yes	No	0	4	3
52	L:L:I28	R:R:F138	5.02	No	Yes	0	0	4
53	R:R:K141	R:R:N139	4.2	No	No	0	3	4
54	R:R:K172	R:R:N139	8.39	No	No	0	3	4
55	R:R:F173	R:R:N139	10.87	No	No	0	3	4
56	R:R:E169	R:R:G142	3.27	No	No	0	5	5
57	R:R:N166	R:R:Y145	3.49	No	No	0	7	4
58	R:R:R146	R:R:W154	6	Yes	No	2	8	9
59	R:R:R146	R:R:T163	6.47	Yes	No	0	8	5
60	R:R:A165	R:R:R146	4.15	No	Yes	2	7	8
61	R:R:R146	R:R:Y167	4.12	Yes	Yes	2	8	5
62	R:R:E155	R:R:R147	15.12	No	No	0	4	3
63	R:R:D149	R:R:N151	5.39	No	No	0	5	5
64	R:R:E155	R:R:W164	8.72	No	No	0	4	5
65	R:R:P158	R:R:V157	3.53	No	Yes	0	4	4
66	R:R:H160	R:R:V157	6.92	No	Yes	0	4	4
67	R:R:A165	R:R:Y167	5.34	No	Yes	2	7	5
68	R:R:N166	R:R:S168	7.45	No	No	0	7	6
69	L:L:I31	R:R:Y167	4.84	No	Yes	0	0	5
70	L:L:H32	R:R:Y167	11.98	No	Yes	0	0	5
71	R:R:E169	R:R:K172	6.75	No	No	0	5	3
72	R:R:N176	R:R:T175	4.39	No	No	0	3	1
73	R:R:N176	R:R:R179	6.03	No	No	0	3	3
74	R:R:R181	R:R:T178	10.35	No	No	0	3	3
75	R:R:E180	R:R:S433	10.06	No	No	0	3	3
76	L:L:W14	R:R:R181	7	No	No	0	0	3
77	R:R:Q438	R:R:V183	8.6	Yes	No	0	4	4
78	R:R:F184	R:R:W437	5.01	No	Yes	0	6	5
79	L:L:R11	R:R:F184	5.34	No	No	0	0	6
80	L:L:W14	R:R:F184	11.02	No	No	0	0	6
81	R:R:H442	R:R:R186	4.51	No	No	0	5	5
82	R:R:L187	R:R:M441	4.24	No	Yes	0	5	6
83	R:R:H442	R:R:L187	7.71	No	No	0	5	5
84	R:R:A188	R:R:Y191	4	No	Yes	0	5	7
85	R:R:I190	R:R:L446	4.28	No	No	0	6	5
86	R:R:D241	R:R:Y191	8.05	No	Yes	0	8	7
87	R:R:M445	R:R:Y191	4.79	No	Yes	0	6	7
88	R:R:G194	R:R:S449	3.71	No	No	0	9	9
89	R:R:R233	R:R:Y195	8.23	Yes	Yes	1	8	7
90	R:R:I237	R:R:Y195	9.67	No	Yes	1	7	7
91	L:L:E4	R:R:Y195	7.86	Yes	Yes	1	0	7
92	R:R:F238	R:R:S196	5.28	No	No	0	7	7
93	R:R:F453	R:R:V197	5.24	No	No	0	6	5
94	R:R:G452	R:R:S198	3.71	No	No	0	9	9
95	R:R:L199	R:R:M231	4.24	No	No	0	7	8
96	R:R:A234	R:R:L199	3.15	No	No	0	8	7
97	R:R:F453	R:R:S201	7.93	No	No	0	6	8
98	R:R:A456	R:R:S201	3.42	No	No	0	8	8
99	R:R:F227	R:R:L202	7.31	Yes	No	0	9	9
100	R:R:F230	R:R:L202	3.65	Yes	No	0	8	9
101	R:R:A456	R:R:L202	3.15	No	No	0	8	9
102	R:R:M231	R:R:T203	6.02	No	No	0	8	3
103	R:R:F461	R:R:V204	3.93	No	No	0	8	5
104	R:R:A205	R:R:C460	3.61	No	No	0	9	9
105	R:R:L228	R:R:V206	4.47	No	No	0	4	5
106	R:R:L209	R:R:M224	4.24	No	No	0	7	5
107	R:R:C460	R:R:L209	3.17	No	No	0	9	7
108	R:R:F212	R:R:Y211	5.16	No	No	0	7	2
109	R:R:F212	R:R:L215	7.31	No	Yes	0	7	9
110	R:R:H216	R:R:R213	3.39	No	No	0	8	8
111	R:R:E469	R:R:R214	9.3	No	No	0	9	7
112	R:R:L215	R:R:V466	4.47	Yes	No	0	9	9
113	R:R:H216	R:R:Y221	4.36	No	No	0	8	7
114	R:R:T218	R:R:Y305	6.24	Yes	Yes	0	7	8
115	R:R:E317	R:R:T218	8.47	No	Yes	0	6	7
116	R:R:N220	R:R:R219	10.85	No	No	0	9	9
117	R:R:E465	R:R:R219	3.49	No	No	0	9	9
118	R:R:H223	R:R:N220	3.83	No	No	0	9	9
119	R:R:E302	R:R:I222	4.1	Yes	No	0	9	9
120	R:R:I222	R:R:Y305	8.46	No	Yes	0	9	8
121	R:R:E302	R:R:H223	8.62	Yes	No	0	9	9
122	R:R:H223	R:R:Y459	5.44	No	No	0	9	8
123	R:R:H225	R:R:W298	14.81	No	Yes	3	8	9
124	R:R:H225	R:R:W329	5.29	No	Yes	3	8	9
125	R:R:F227	R:R:L226	4.87	Yes	No	0	9	9
126	R:R:F230	R:R:L226	8.53	Yes	No	0	8	9
127	R:R:E302	R:R:L226	15.9	Yes	No	0	9	9
128	R:R:S229	R:R:T294	3.2	No	Yes	3	9	8
129	R:R:N295	R:R:S229	5.96	No	No	0	8	9
130	R:R:S229	R:R:W329	3.71	No	Yes	3	9	9
131	R:R:F230	R:R:N295	9.67	Yes	No	0	8	8
132	R:R:F230	R:R:V455	3.93	Yes	No	0	8	9
133	R:R:F291	R:R:L232	18.27	No	No	0	5	8
134	R:R:L292	R:R:R233	6.07	No	Yes	1	6	8
135	R:R:N295	R:R:R233	10.85	No	Yes	0	8	8
136	R:R:R233	R:R:Y296	9.26	Yes	Yes	1	8	7
137	L:L:E4	R:R:R233	11.63	Yes	Yes	1	0	8
138	R:R:F291	R:R:S236	9.25	No	No	0	5	7
139	L:L:E4	R:R:I237	5.47	Yes	No	1	0	7
140	R:R:K240	R:R:L244	5.64	No	No	0	7	5
141	L:L:R11	R:R:L244	4.86	No	No	0	0	5
142	R:R:C281	R:R:C351	7.28	No	No	0	9	9
143	R:R:N348	R:R:R282	4.82	No	No	0	7	8
144	R:R:R282	R:R:W352	22.99	No	Yes	0	8	8
145	R:R:F287	R:R:V283	3.93	No	No	0	3	4
146	R:R:T286	R:R:V340	3.17	No	No	0	7	5
147	L:L:E4	R:R:F288	3.5	Yes	No	0	0	7
148	L:L:M8	R:R:F288	6.22	No	No	0	0	7
149	R:R:L289	R:R:W339	10.25	No	No	0	7	8
150	R:R:I363	R:R:L289	5.71	No	No	0	7	7
151	R:R:F291	R:R:Y290	7.22	No	Yes	0	5	9
152	R:R:T294	R:R:Y290	7.49	Yes	Yes	0	8	9
153	R:R:A333	R:R:Y290	5.34	No	Yes	0	5	9
154	R:R:V336	R:R:Y290	6.31	No	Yes	0	7	9
155	R:R:L292	R:R:Y296	8.21	No	Yes	1	6	7
156	L:L:E4	R:R:L292	6.63	Yes	No	1	0	6
157	R:R:A293	R:R:P332	3.74	No	Yes	0	6	9
158	R:R:A293	R:R:I367	3.25	No	No	0	6	7
159	R:R:T294	R:R:W329	7.28	Yes	Yes	3	8	9
160	R:R:P332	R:R:T294	5.25	Yes	Yes	0	9	8
161	R:R:I367	R:R:Y296	3.63	No	Yes	0	7	7
162	R:R:Y296	R:R:Y421	13.9	Yes	Yes	1	7	8
163	R:R:F327	R:R:Y297	5.16	No	No	0	5	6
164	R:R:P332	R:R:Y297	6.95	Yes	No	0	9	6
165	R:R:F335	R:R:Y297	5.16	No	No	0	5	6
166	R:R:V301	R:R:W298	9.81	No	Yes	0	8	9
167	R:R:G328	R:R:W298	7.04	No	Yes	0	9	9
168	R:R:W298	R:R:W329	18.74	Yes	Yes	3	9	9
169	R:R:I299	R:R:N374	4.25	No	No	0	9	9
170	R:R:F327	R:R:L300	3.65	No	No	0	5	8
171	R:R:L300	R:R:L373	5.54	No	No	0	8	7
172	R:R:F324	R:R:V301	3.93	No	No	0	7	8
173	R:R:E302	R:R:L416	3.98	Yes	No	0	9	9
174	R:R:F417	R:R:G303	4.52	Yes	No	0	9	9
175	R:R:L309	R:R:Y305	15.24	No	Yes	0	8	8
176	R:R:F315	R:R:Y305	4.13	No	Yes	0	6	8
177	R:R:F324	R:R:Y305	5.16	No	Yes	0	7	8
178	R:R:I381	R:R:L306	4.28	No	No	0	9	9
179	R:R:F417	R:R:L306	4.87	Yes	No	0	9	9
180	R:R:F311	R:R:H307	9.05	No	Yes	8	6	8
181	R:R:H307	R:R:L377	9	Yes	No	0	8	7
182	R:R:H307	R:R:N380	8.93	Yes	No	8	8	8
183	R:R:H307	R:R:I381	5.3	Yes	No	0	8	9
184	R:R:F311	R:R:I310	3.77	No	No	0	6	8
185	R:R:F311	R:R:N380	8.46	No	No	8	6	8
186	R:R:F315	R:R:Y320	11.35	No	No	0	6	4
187	R:R:K319	R:R:S316	4.59	No	No	0	6	7
188	R:R:T325	R:R:W322	3.64	No	No	0	5	3
189	R:R:F327	R:R:L331	3.65	No	No	0	5	4
190	R:R:L331	R:R:P332	3.28	No	Yes	0	4	9
191	R:R:F335	R:R:L331	6.09	No	No	0	5	4
192	R:R:F335	R:R:P366	17.34	No	No	0	5	9
193	R:R:W339	R:R:W352	3.75	No	Yes	0	8	8
194	R:R:I362	R:R:W339	7.05	No	No	0	8	8
195	R:R:V340	R:R:W352	4.9	No	Yes	0	5	8
196	R:R:K359	R:R:V342	6.07	No	Yes	0	3	5
197	R:R:I362	R:R:V342	4.61	No	Yes	0	8	5
198	R:R:R343	R:R:W352	17.99	No	Yes	0	8	8
199	R:R:K359	R:R:L346	9.87	No	No	0	3	3
200	L:L:M8	R:R:D353	6.93	No	No	0	0	5
201	L:L:A12	R:R:D353	6.18	No	No	0	0	5
202	L:L:A12	R:R:L354	3.15	No	No	0	0	5
203	L:L:Q16	R:R:L354	7.99	No	No	0	0	5
204	L:L:H9	R:R:S355	6.97	No	No	0	0	7
205	R:R:K359	R:R:S356	7.65	No	No	0	3	4
206	R:R:N358	R:R:W361	3.39	No	Yes	0	4	8
207	R:R:K360	R:R:W361	5.8	No	Yes	0	7	8
208	R:R:K360	R:R:Y429	15.53	No	Yes	0	7	6
209	R:R:Q364	R:R:W361	5.48	Yes	Yes	0	7	8
210	R:R:V365	R:R:W361	4.9	No	Yes	0	5	8
211	R:R:Q364	R:R:Y429	3.38	Yes	Yes	0	7	6
212	L:L:V2	R:R:Q364	8.6	No	Yes	9	0	7
213	L:L:I5	R:R:Q364	5.49	No	Yes	9	0	7
214	R:R:P366	R:R:V365	3.53	No	No	0	9	5
215	R:R:I371	R:R:M425	8.75	No	Yes	0	7	6
216	R:R:F417	R:R:N374	7.25	Yes	No	0	9	9
217	R:R:F375	R:R:I422	11.3	No	No	0	7	5
218	R:R:F378	R:R:V382	7.87	Yes	No	0	9	7
219	R:R:F378	R:R:L413	6.09	Yes	No	7	9	9
220	R:R:F378	R:R:F417	7.5	Yes	Yes	7	9	9
221	R:R:F378	R:R:V419	9.18	Yes	No	0	9	7
222	R:R:N380	R:R:R383	4.82	No	No	0	8	8
223	R:R:E391	R:R:T387	5.64	No	No	0	7	7
224	R:R:L389	R:R:Q402	6.65	No	No	0	8	6
225	R:R:K405	R:R:L389	4.23	No	No	0	8	8
226	R:R:L389	R:R:L406	4.15	No	No	0	8	8
227	R:R:L407	R:R:L411	4.15	No	No	0	8	8
228	R:R:K408	R:R:V412	4.55	No	No	0	8	8
229	R:R:I458	R:R:V412	7.68	No	No	0	8	8
230	R:R:F417	R:R:L413	6.09	Yes	No	7	9	9
231	R:R:M414	R:R:V419	9.13	No	No	0	8	7
232	R:R:F417	R:R:L416	7.31	Yes	No	0	9	9
233	R:R:L416	R:R:Y459	12.89	No	No	0	9	8
234	R:R:G418	R:R:H420	3.18	No	Yes	0	9	8
235	R:R:H420	R:R:Y421	17.42	Yes	Yes	1	8	8
236	R:R:F447	R:R:H420	6.79	No	Yes	0	5	8
237	R:R:H420	R:R:N448	5.1	Yes	No	1	8	6
238	R:R:H420	R:R:Q451	7.42	Yes	No	1	8	9
239	R:R:N448	R:R:Y421	10.47	No	Yes	1	6	8
240	R:R:Q451	R:R:Y421	10.15	No	Yes	1	9	8
241	R:R:I422	R:R:M425	4.37	No	Yes	0	5	6
242	R:R:F424	R:R:V423	6.55	Yes	No	10	7	6
243	R:R:V423	R:R:Y443	10.09	No	Yes	10	6	4
244	R:R:F424	R:R:Q440	9.37	Yes	No	0	7	6
245	R:R:F424	R:R:Y443	7.22	Yes	Yes	10	7	4
246	R:R:Q440	R:R:T427	7.09	No	No	0	6	5
247	L:L:A1	R:R:Y429	4	No	Yes	0	0	6
248	L:L:Q6	R:R:Y429	9.02	No	Yes	0	0	6
249	L:L:Q10	R:R:Y429	3.38	No	Yes	0	0	6
250	R:R:T430	R:R:W437	4.85	No	Yes	0	5	5
251	L:L:Q10	R:R:V432	4.3	No	No	0	0	5
252	R:R:Q438	R:R:W437	3.29	Yes	Yes	0	4	5
253	R:R:M441	R:R:W437	8.14	Yes	Yes	0	6	5
254	L:L:Q10	R:R:W437	5.48	No	Yes	0	0	5
255	R:R:H442	R:R:Q438	3.71	No	Yes	0	5	4
256	L:L:Q6	R:R:Q440	7.68	No	No	0	0	6
257	L:L:Q6	R:R:M441	5.44	No	Yes	0	0	6
258	L:L:L7	R:R:M441	8.48	No	Yes	0	0	6
259	R:R:E444	R:R:Y443	4.49	No	Yes	0	7	4
260	R:R:F447	R:R:Y443	9.28	No	Yes	0	5	4
261	R:R:E444	R:R:N448	7.89	No	No	0	7	6
262	L:L:A3	R:R:E444	6.03	No	No	0	0	7
263	L:L:E4	R:R:M445	4.06	Yes	No	0	0	6
264	R:R:F450	R:R:S449	5.28	No	No	0	7	9
265	R:R:F450	R:R:F454	4.29	No	No	0	7	6
266	R:R:F453	R:R:I457	10.05	No	No	0	6	6
267	R:R:F461	R:R:I457	5.02	No	No	0	8	6
268	R:R:I458	R:R:Y459	8.46	No	No	0	8	8
269	R:R:N463	R:R:V466	5.91	No	No	0	9	9
270	R:R:T478	R:R:W474	6.06	No	No	0	4	5
271	R:R:S475	R:R:T478	3.2	No	No	0	4	4
272	L:L:I5	L:L:V2	10.75	No	No	9	0	0
273	L:L:I15	L:L:R19	3.76	No	No	0	0	0
274	L:L:Q16	L:L:R19	4.67	No	No	0	0	0
275	L:L:D17	L:L:R20	9.53	No	No	0	0	0
276	L:L:D17	L:L:R21	5.96	No	No	0	0	0
277	R:R:I208	R:R:V204	3.07	No	No	0	8	5
278	R:R:M312	R:R:S308	3.07	No	No	0	5	7
279	R:R:I310	R:R:V384	3.07	No	No	0	8	8
280	R:R:I470	R:R:V466	3.07	No	No	0	5	9
281	L:L:K13	R:R:S355	3.06	No	No	0	0	7
282	R:R:K405	R:R:S409	3.06	No	No	0	8	9
283	R:R:K240	R:R:V285	3.04	No	No	0	7	6
284	L:L:M8	R:R:V285	3.04	No	No	0	0	6
285	R:R:M425	R:R:V372	3.04	Yes	No	0	6	4
286	R:R:A122	R:R:E125	3.02	No	No	0	1	5
287	R:R:F230	R:R:G452	3.01	Yes	No	0	8	9
288	R:R:M414	R:R:T410	3.01	No	No	0	8	9
289	R:R:L479	R:R:S475	3	No	No	0	4	4
290	R:R:L199	R:R:V235	2.98	No	No	0	7	4
291	R:R:L289	R:R:V336	2.98	No	No	0	7	7
292	R:R:L346	R:R:T345	2.95	No	No	0	3	3
293	R:R:L406	R:R:T410	2.95	No	No	0	8	9
294	R:R:I190	R:R:M445	2.92	No	No	0	6	6
295	R:R:F454	R:R:P415	2.89	No	No	0	6	9
296	R:R:Q438	R:R:S433	2.89	Yes	No	0	4	3
297	R:R:P107	R:R:R106	2.88	No	No	0	3	1
298	R:R:K50	R:R:K53	2.87	No	No	0	4	5
299	R:R:E169	R:R:S168	2.87	No	No	0	5	6
300	L:L:I28	L:L:L24	2.85	No	No	0	0	0
301	R:R:C170	R:R:F138	2.79	No	Yes	0	9	4
302	R:R:A205	R:R:F227	2.77	No	Yes	0	9	9
303	R:R:L304	R:R:L377	2.77	No	No	0	5	7
304	R:R:A347	R:R:R343	2.77	No	No	0	7	8
305	R:R:H225	R:R:T325	2.74	No	No	0	8	5
306	R:R:A128	R:R:Y145	2.67	No	No	0	5	4
307	R:R:A144	R:R:Y167	2.67	No	Yes	0	7	5
308	R:R:L368	R:R:Q364	2.66	No	Yes	0	4	7
309	R:R:H42	R:R:I38	2.65	No	No	0	4	7
310	R:R:E465	R:R:L215	2.65	No	Yes	0	9	9
311	R:R:E469	R:R:L215	2.65	No	Yes	0	9	9
312	L:L:H9	L:L:I5	2.65	No	No	0	0	0
313	R:R:F315	R:R:S308	2.64	No	No	0	6	7
314	R:R:F227	R:R:V206	2.62	Yes	No	0	9	5
315	R:R:F375	R:R:V419	2.62	No	No	0	7	7
316	R:R:F238	R:R:T192	2.59	No	No	0	7	7
317	R:R:A344	R:R:W352	2.59	No	Yes	0	4	8
318	R:R:R390	R:R:T387	2.59	No	No	0	6	7
319	R:R:S449	R:R:Y195	2.54	No	Yes	0	9	7
320	R:R:S316	R:R:Y320	2.54	No	No	0	7	4
321	R:R:F375	R:R:I379	2.51	No	No	0	7	5
322	R:R:T192	R:R:Y191	2.5	No	Yes	0	7	7
323	L:L:R19	R:R:K34	2.48	No	No	0	0	4
324	R:R:V157	R:R:W164	2.45	Yes	No	0	4	5
325	R:R:L321	R:R:Y221	2.34	No	No	0	6	7
326	L:L:E30	R:R:R162	2.33	No	No	0	0	3
327	R:R:E182	R:R:R186	2.33	No	No	0	2	5
328	R:R:C108	R:R:G152	1.96	No	No	0	9	9
329	R:R:C131	R:R:G142	1.96	No	No	0	9	5
330	R:R:A276	R:R:G350	1.95	No	No	0	4	5
331	R:R:A122	R:R:P123	1.87	No	No	0	1	7
332	R:R:G357	R:R:S356	1.86	No	No	0	6	4
333	R:R:G434	R:R:S433	1.86	No	No	0	5	3
334	R:R:G194	R:R:V193	1.84	No	No	0	9	6
335	R:R:G280	R:R:V283	1.84	No	No	0	4	4
336	R:R:G350	R:R:T349	1.82	No	No	0	5	5
337	R:R:A276	R:R:C351	1.81	No	No	0	4	9
338	R:R:P428	R:R:T427	1.75	No	No	0	7	5
339	R:R:A284	R:R:V243	1.7	No	No	0	6	5
340	R:R:G464	R:R:N463	1.7	No	No	0	7	9
341	R:R:C217	R:R:T218	1.69	No	Yes	0	8	7
342	R:R:D149	R:R:G152	1.68	No	No	0	5	9
343	R:R:A347	R:R:T349	1.68	No	No	0	7	5
344	R:R:L120	R:R:P107	1.64	No	No	0	4	3
345	R:R:S341	R:R:V342	1.62	No	Yes	0	5	5
346	R:R:A210	R:R:M224	1.61	No	No	0	4	5
347	R:R:A284	R:R:K240	1.61	No	No	0	6	7
348	R:R:A426	R:R:M425	1.61	No	Yes	0	5	6
349	R:R:V338	R:R:V342	1.6	No	Yes	0	5	5
350	R:R:C48	R:R:L52	1.59	No	No	0	8	4
351	R:R:I367	R:R:S370	1.55	No	No	0	7	7
352	R:R:I371	R:R:S370	1.55	No	No	0	7	7
353	R:R:I376	R:R:V372	1.54	No	No	0	4	4
354	R:R:M231	R:R:V206	1.52	No	No	0	8	5
355	R:R:G124	R:R:R150	1.5	No	No	0	7	1
356	R:R:G277	R:R:R282	1.5	No	No	0	4	8
357	R:R:L385	R:R:S409	1.5	No	No	0	8	9
358	R:R:L174	R:R:V171	1.49	No	No	0	3	3
359	R:R:D149	R:R:S153	1.47	No	No	0	5	4
360	R:R:L156	R:R:T163	1.47	No	No	0	4	5
361	R:R:L321	R:R:T218	1.47	No	Yes	0	6	7
362	R:R:L436	R:R:T430	1.47	No	No	0	4	5
363	R:R:Q401	R:R:T399	1.42	No	No	0	6	6
364	R:R:Q402	R:R:T399	1.42	No	No	0	6	6
365	R:R:L40	R:R:M32	1.41	No	No	0	5	6
366	R:R:E35	R:R:T33	1.41	No	No	0	5	7
367	R:R:E177	R:R:T178	1.41	No	No	0	1	3
368	R:R:G330	R:R:W329	1.41	No	Yes	0	7	9
369	R:R:L411	R:R:M414	1.41	No	No	0	8	8
370	R:R:E431	R:R:T430	1.41	No	No	0	3	5
371	R:R:L156	R:R:N161	1.37	No	No	0	4	7
372	R:R:E36	R:R:M32	1.35	No	No	0	6	6
373	R:R:F212	R:R:S473	1.32	No	No	0	7	4
374	R:R:R162	R:R:V157	1.31	No	Yes	0	3	4
375	R:R:E180	R:R:N176	1.31	No	No	0	3	3
376	R:R:F424	R:R:V439	1.31	Yes	No	0	7	5
377	R:R:H42	R:R:Q45	1.24	No	No	0	4	7
378	R:R:D185	R:R:R181	1.19	No	No	0	2	3
379	R:R:L40	R:R:Y134	1.17	No	Yes	0	5	5
380	R:R:Q402	R:R:R390	1.17	No	No	0	6	6
381	R:R:K318	R:R:W322	1.16	No	No	0	5	3
382	R:R:L481	R:R:W477	1.14	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:P110	3.3425	4	6	6
2	R:R:W112	8.1575	4	0	7
3	R:R:W118	11.374	5	2	9
4	R:R:Y134	3.88	4	5	5
5	R:R:I135	7.5925	4	5	7
6	R:R:F138	7.0175	4	0	4
7	R:R:R146	9.32429	7	2	8
8	R:R:V157	3.5525	4	0	4
9	R:R:Y167	5.62	7	2	5
10	R:R:Y191	4.835	4	0	7
11	R:R:Y195	7.075	4	1	7
12	R:R:L215	4.27	4	0	9
13	R:R:T218	4.4675	4	0	7
14	R:R:F227	4.3925	4	0	9
15	R:R:F230	5.758	5	0	8
16	R:R:R233	9.208	5	1	8
17	R:R:Y290	6.59	4	0	9
18	R:R:T294	5.805	4	3	8
19	R:R:Y296	8.75	4	1	7
20	R:R:W298	12.6	4	3	9
21	R:R:E302	8.15	4	0	9
22	R:R:Y305	7.846	5	0	8
23	R:R:H307	8.07	4	8	8
24	R:R:W329	7.286	5	3	9
25	R:R:P332	4.805	4	0	9
26	R:R:V342	3.475	4	0	5
27	R:R:W352	10.444	5	0	8
28	R:R:W361	4.8925	4	0	8
29	R:R:Q364	5.122	5	9	7
30	R:R:F378	7.66	4	7	9
31	R:R:F417	6.25667	6	7	9
32	R:R:H420	7.982	5	1	8
33	R:R:Y421	12.985	4	1	8
34	R:R:F424	6.1125	4	10	7
35	R:R:M425	4.4425	4	0	6
36	R:R:Y429	7.062	5	0	6
37	R:R:W437	5.354	5	0	5
38	R:R:Q438	4.6225	4	0	4
39	R:R:M441	6.575	4	0	6
40	R:R:Y443	7.77	4	10	4
41	L:L:E4	6.525	6	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:A12	R:R:L354	11.1736	3.15	No	No	0	0	5
2	L:L:A12	R:R:D353	13.0012	6.18	No	No	0	0	5
3	L:L:M8	R:R:D353	14.8188	6.93	No	No	0	0	5
4	L:L:M8	R:R:V285	29.1211	3.04	No	No	0	0	6
5	R:R:K240	R:R:V285	27.8554	3.04	No	No	0	7	6
6	R:R:K240	R:R:L244	24.2558	5.64	No	No	0	7	5
7	L:L:R11	R:R:L244	23.1926	4.86	No	No	0	0	5
8	L:L:R11	R:R:F184	22.3117	5.34	No	No	0	0	6
9	R:R:F184	R:R:W437	21.2181	5.01	No	Yes	0	6	5
10	L:L:Q10	R:R:W437	30.4324	5.48	No	Yes	0	0	5
11	L:L:Q10	R:R:Y429	38.8467	3.38	No	Yes	0	0	6
12	R:R:Q364	R:R:Y429	32.5081	3.38	Yes	Yes	0	7	6
13	L:L:I5	R:R:Q364	15.4364	5.49	No	Yes	9	0	7
14	L:L:H9	L:L:I5	12.3886	2.65	No	No	0	0	0
15	R:R:Q438	R:R:W437	26.7872	3.29	Yes	Yes	0	4	5
16	R:R:Q438	R:R:S433	15.3959	2.89	Yes	No	0	4	3
17	R:R:E180	R:R:S433	10.3028	10.06	No	No	0	3	3
18	L:L:W14	R:R:F184	11.7659	11.02	No	No	0	0	6
19	L:L:Q6	R:R:Y429	22.3471	9.02	No	Yes	0	0	6
20	L:L:Q6	R:R:M441	22.5243	5.44	No	Yes	0	0	6
21	R:R:L187	R:R:M441	11.6798	4.24	No	Yes	0	5	6
22	R:R:H442	R:R:R186	10.1205	4.51	No	No	0	5	5
23	R:R:Q364	R:R:W361	45.6308	5.48	Yes	Yes	0	7	8
24	R:R:V365	R:R:W361	78.0883	4.9	No	Yes	0	5	8
25	R:R:P366	R:R:V365	80.1185	3.53	No	No	0	9	5
26	R:R:F335	R:R:P366	82.3208	17.34	No	No	0	5	9
27	R:R:F335	R:R:Y297	42.335	5.16	No	No	0	5	6
28	R:R:P332	R:R:Y297	46.2839	6.95	Yes	No	0	9	6
29	R:R:A293	R:R:P332	27.3188	3.74	No	Yes	0	6	9
30	R:R:A293	R:R:I367	26.9694	3.25	No	No	0	6	7
31	R:R:I367	R:R:Y296	35.8951	3.63	No	Yes	0	7	7
32	R:R:R233	R:R:Y296	46.2991	9.26	Yes	Yes	1	8	7
33	L:L:E4	R:R:R233	49.5494	11.63	Yes	Yes	1	0	8
34	L:L:E4	R:R:M445	21.9117	4.06	Yes	No	0	0	6
35	R:R:M445	R:R:Y191	14.6972	4.79	No	Yes	0	6	7
36	R:R:F335	R:R:L331	42.335	6.09	No	No	0	5	4
37	R:R:L331	R:R:P332	46.2839	3.28	No	Yes	0	4	9
38	L:L:Q6	R:R:Q440	27.8807	7.68	No	No	0	0	6
39	R:R:F424	R:R:Q440	32.1031	9.37	Yes	No	0	7	6
40	R:R:F424	R:R:Y443	36.5634	7.22	Yes	Yes	10	7	4
41	R:R:E444	R:R:Y443	20.7928	4.49	No	Yes	0	7	4
42	R:R:E444	R:R:N448	23.1015	7.89	No	No	0	7	6
43	R:R:N448	R:R:Y421	24.2355	10.47	No	Yes	1	6	8
44	R:R:Y296	R:R:Y421	50.8303	13.9	Yes	Yes	1	7	8
45	R:R:F447	R:R:Y443	21.0308	9.28	No	Yes	0	5	4
46	R:R:F447	R:R:H420	22.175	6.79	No	Yes	0	5	8
47	R:R:H420	R:R:Y421	24.2406	17.42	Yes	Yes	1	8	8
48	R:R:P332	R:R:T294	85.1306	5.25	Yes	Yes	0	9	8
49	R:R:S229	R:R:T294	55.9842	3.2	No	Yes	3	9	8
50	R:R:N295	R:R:S229	62.9	5.96	No	No	0	8	9
51	R:R:N295	R:R:R233	77.015	10.85	No	Yes	0	8	8
52	R:R:L292	R:R:Y296	12.0595	8.21	No	Yes	1	6	7
53	L:L:E4	R:R:L292	11.7051	6.63	Yes	No	1	0	6
54	L:L:M8	R:R:F288	40.9224	6.22	No	No	0	0	7
55	L:L:E4	R:R:F288	42.3299	3.5	Yes	No	0	0	7
56	R:R:R233	R:R:Y195	12.6772	8.23	Yes	Yes	1	8	7
57	R:R:S449	R:R:Y195	11.2039	2.54	No	Yes	0	9	7
58	R:R:F230	R:R:N295	100	9.67	Yes	No	0	8	8
59	R:R:F230	R:R:L202	27.4757	3.65	Yes	No	0	8	9
60	R:R:A456	R:R:L202	15.6288	3.15	No	No	0	8	9
61	R:R:A456	R:R:S201	13.71	3.42	No	No	0	8	8
62	R:R:F453	R:R:S201	11.7811	7.93	No	No	0	6	8
63	R:R:F227	R:R:L202	18.226	7.31	Yes	No	0	9	9
64	R:R:F227	R:R:V206	18.6361	2.62	Yes	No	0	9	5
65	R:R:M231	R:R:V206	13.3607	1.52	No	No	0	8	5
66	R:R:F230	R:R:L226	77.6124	8.53	Yes	No	0	8	9
67	R:R:F227	R:R:L226	23.0964	4.87	Yes	No	0	9	9
68	R:R:A205	R:R:F227	13.3607	2.77	No	Yes	0	9	9
69	R:R:A205	R:R:C460	10.7078	3.61	No	No	0	9	9
70	R:R:E302	R:R:L226	71.7092	15.9	Yes	No	0	9	9
71	R:R:E302	R:R:H223	27.096	8.62	Yes	No	0	9	9
72	R:R:H223	R:R:N220	23.2787	3.83	No	No	0	9	9
73	R:R:N220	R:R:R219	21.5472	10.85	No	No	0	9	9
74	R:R:E465	R:R:R219	19.8056	3.49	No	No	0	9	9
75	R:R:E465	R:R:L215	18.0539	2.65	No	Yes	0	9	9
76	R:R:T294	R:R:W329	23.2938	7.28	Yes	Yes	3	8	9
77	R:R:W298	R:R:W329	19.8005	18.74	Yes	Yes	3	9	9
78	R:R:V301	R:R:W298	19.112	9.81	No	Yes	0	8	9
79	R:R:F324	R:R:V301	18.1956	3.93	No	No	0	7	8
80	R:R:F324	R:R:Y305	17.4716	5.16	No	Yes	0	7	8
81	R:R:T218	R:R:Y305	14.0998	6.24	Yes	Yes	0	7	8
82	R:R:E302	R:R:I222	19.3297	4.1	Yes	No	0	9	9
83	R:R:I222	R:R:Y305	18.3829	8.46	No	Yes	0	9	8
84	R:R:E302	R:R:L416	45.5093	3.98	Yes	No	0	9	9
85	R:R:T294	R:R:Y290	68.0387	7.49	Yes	Yes	0	8	9
86	R:R:V336	R:R:Y290	58.0903	6.31	No	Yes	0	7	9
87	R:R:L289	R:R:V336	56.0703	2.98	No	No	0	7	7
88	R:R:L289	R:R:W339	51.9998	10.25	No	No	0	7	8
89	R:R:W339	R:R:W352	31.0399	3.75	No	Yes	0	8	8
90	R:R:R343	R:R:W352	15.7655	17.99	No	Yes	0	8	8
91	R:R:A347	R:R:R343	13.5429	2.77	No	No	0	7	8
92	R:R:A347	R:R:T349	11.3102	1.68	No	No	0	7	5
93	R:R:F417	R:R:L416	42.7248	7.31	Yes	No	0	9	9
94	R:R:F315	R:R:Y305	12.1152	4.13	No	Yes	0	6	8
95	R:R:F417	R:R:L306	16.692	4.87	Yes	No	0	9	9
96	R:R:I381	R:R:L306	15.077	4.28	No	No	0	9	9
97	R:R:H307	R:R:I381	13.4417	5.3	Yes	No	0	8	9
98	R:R:I362	R:R:W339	20.1802	7.05	No	No	0	8	8
99	R:R:I362	R:R:V342	17.9779	4.61	No	Yes	0	8	5
100	R:R:K359	R:R:V342	11.3102	6.07	No	Yes	0	3	5
101	R:R:K360	R:R:W361	29.1515	5.8	No	Yes	0	7	8
102	R:R:K360	R:R:Y429	27.5111	15.53	No	Yes	0	7	6
103	R:R:I367	R:R:S370	33.0093	1.55	No	No	0	7	7
104	R:R:I371	R:R:S370	31.5158	1.55	No	No	0	7	7
105	R:R:I371	R:R:M425	30.2855	8.75	No	Yes	0	7	6
106	R:R:I422	R:R:M425	26.4986	4.37	No	Yes	0	5	6
107	R:R:F375	R:R:I422	25.7847	11.3	No	No	0	7	5
108	R:R:F375	R:R:V419	24.5089	2.62	No	No	0	7	7
109	R:R:F378	R:R:V419	20.6207	9.18	Yes	No	0	9	7
110	R:R:F378	R:R:F417	22.3269	7.5	Yes	Yes	7	9	9
111	R:R:M414	R:R:V419	33.1814	9.13	No	No	0	8	7
112	R:R:M414	R:R:T410	26.7264	3.01	No	No	0	8	9
113	R:R:L406	R:R:T410	24.5545	2.95	No	No	0	8	9
114	R:R:L389	R:R:L406	22.3724	4.15	No	No	0	8	8
115	R:R:L389	R:R:Q402	13.5429	6.65	No	No	0	8	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:K13	R:R:V31	9.11	0	No	No	0	6	0	1
R:R:M32	R:R:Y136	3.59	0	No	No	6	4	2	1
L:L:F23	R:R:K34	4.96	0	No	No	0	4	0	1
R:R:D113	R:R:W118	11.17	2	No	Yes	9	9	2	2
R:R:D113	R:R:R146	10.72	2	No	Yes	9	8	2	2
R:R:D113	R:R:Y167	4.6	2	No	Yes	9	5	2	1
L:L:L27	R:R:I115	7.14	0	No	No	0	5	0	1
L:L:I31	R:R:I115	5.89	0	No	No	0	5	0	1
R:R:R146	R:R:W118	27.99	2	Yes	Yes	8	9	2	2
R:R:W118	R:R:Y167	5.79	2	Yes	Yes	9	5	2	1
R:R:F138	R:R:I135	16.33	0	Yes	Yes	4	7	1	2
R:R:D137	R:R:Y136	4.6	4	No	No	5	4	1	1
L:L:R20	R:R:Y136	7.2	4	No	No	0	4	0	1
L:L:R20	R:R:D137	3.57	4	No	No	0	5	0	1
L:L:R21	R:R:D137	9.53	0	No	No	0	5	0	1
R:R:F138	R:R:V171	3.93	0	Yes	No	4	3	1	2
L:L:I28	R:R:F138	5.02	0	No	Yes	0	4	0	1
R:R:A165	R:R:R146	4.15	2	No	Yes	7	8	2	2
R:R:R146	R:R:Y167	4.12	2	Yes	Yes	8	5	2	1
R:R:A165	R:R:Y167	5.34	2	No	Yes	7	5	2	1
L:L:I31	R:R:Y167	4.84	0	No	Yes	0	5	0	1
L:L:H32	R:R:Y167	11.98	0	No	Yes	0	5	0	1
R:R:R181	R:R:T178	10.35	0	No	No	3	3	1	2
L:L:W14	R:R:R181	7	0	No	No	0	3	0	1
R:R:F184	R:R:W437	5.01	0	No	Yes	6	5	1	1
L:L:R11	R:R:F184	5.34	0	No	No	0	6	0	1
L:L:W14	R:R:F184	11.02	0	No	No	0	6	0	1
R:R:L187	R:R:M441	4.24	0	No	Yes	5	6	2	1
R:R:M445	R:R:Y191	4.79	0	No	Yes	6	7	1	2
R:R:R233	R:R:Y195	8.23	1	Yes	Yes	8	7	1	1
R:R:I237	R:R:Y195	9.67	1	No	Yes	7	7	1	1
L:L:E4	R:R:Y195	7.86	1	Yes	Yes	0	7	0	1
R:R:L292	R:R:R233	6.07	1	No	Yes	6	8	1	1
R:R:N295	R:R:R233	10.85	0	No	Yes	8	8	2	1
R:R:R233	R:R:Y296	9.26	1	Yes	Yes	8	7	1	2
L:L:E4	R:R:R233	11.63	1	Yes	Yes	0	8	0	1
L:L:E4	R:R:I237	5.47	1	Yes	No	0	7	0	1
R:R:K240	R:R:L244	5.64	0	No	No	7	5	2	1
L:L:R11	R:R:L244	4.86	0	No	No	0	5	0	1
L:L:E4	R:R:F288	3.5	1	Yes	No	0	7	0	1
L:L:M8	R:R:F288	6.22	0	No	No	0	7	0	1
R:R:L292	R:R:Y296	8.21	1	No	Yes	6	7	1	2
L:L:E4	R:R:L292	6.63	1	Yes	No	0	6	0	1
L:L:M8	R:R:D353	6.93	0	No	No	0	5	0	1
L:L:A12	R:R:D353	6.18	0	No	No	0	5	0	1
L:L:A12	R:R:L354	3.15	0	No	No	0	5	0	1
L:L:Q16	R:R:L354	7.99	0	No	No	0	5	0	1
L:L:H9	R:R:S355	6.97	0	No	No	0	7	0	1
R:R:K360	R:R:W361	5.8	0	No	Yes	7	8	2	2
R:R:K360	R:R:Y429	15.53	0	No	Yes	7	6	2	1
R:R:Q364	R:R:W361	5.48	9	Yes	Yes	7	8	1	2
R:R:Q364	R:R:Y429	3.38	9	Yes	Yes	7	6	1	1
L:L:V2	R:R:Q364	8.6	9	No	Yes	0	7	0	1
L:L:I5	R:R:Q364	5.49	9	No	Yes	0	7	0	1
R:R:F424	R:R:Q440	9.37	10	Yes	No	7	6	2	1
R:R:F424	R:R:Y443	7.22	10	Yes	Yes	7	4	2	2
R:R:Q440	R:R:T427	7.09	0	No	No	6	5	1	2
L:L:A1	R:R:Y429	4	0	No	Yes	0	6	0	1
L:L:Q6	R:R:Y429	9.02	0	No	Yes	0	6	0	1
L:L:Q10	R:R:Y429	3.38	0	No	Yes	0	6	0	1
R:R:T430	R:R:W437	4.85	0	No	Yes	5	5	2	1
L:L:Q10	R:R:V432	4.3	0	No	No	0	5	0	1
R:R:Q438	R:R:W437	3.29	0	Yes	Yes	4	5	2	1
R:R:M441	R:R:W437	8.14	0	Yes	Yes	6	5	1	1
L:L:Q10	R:R:W437	5.48	0	No	Yes	0	5	0	1
L:L:Q6	R:R:Q440	7.68	0	No	No	0	6	0	1
L:L:Q6	R:R:M441	5.44	0	No	Yes	0	6	0	1
L:L:L7	R:R:M441	8.48	0	No	Yes	0	6	0	1
R:R:E444	R:R:Y443	4.49	0	No	Yes	7	4	1	2
R:R:E444	R:R:N448	7.89	0	No	No	7	6	1	2
L:L:A3	R:R:E444	6.03	0	No	No	0	7	0	1
L:L:E4	R:R:M445	4.06	1	Yes	No	0	6	0	1
L:L:K13	R:R:S355	3.06	0	No	No	0	7	0	1
R:R:K240	R:R:V285	3.04	0	No	No	7	6	2	1
L:L:M8	R:R:V285	3.04	0	No	No	0	6	0	1
R:R:I190	R:R:M445	2.92	0	No	No	6	6	2	1
R:R:C170	R:R:F138	2.79	0	No	Yes	9	4	2	1
R:R:A144	R:R:Y167	2.67	0	No	Yes	7	5	2	1
R:R:L368	R:R:Q364	2.66	0	No	Yes	4	7	2	1
R:R:S449	R:R:Y195	2.54	0	No	Yes	9	7	2	1
L:L:R19	R:R:K34	2.48	0	No	No	0	4	0	1
L:L:E30	R:R:R162	2.33	0	No	No	0	3	0	1
R:R:R162	R:R:V157	1.31	0	No	Yes	3	4	1	2
R:R:D185	R:R:R181	1.19	0	No	No	2	3	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6NBF_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.15
Number of Linked Nodes	358
Number of Links	382
Number of Hubs	41
Number of Links mediated by Hubs	162
Number of Communities	10
Number of Nodes involved in Communities	43
Number of Links involved in Communities	53

Path Summary
Number Of Nodes in MetaPath	116
Number Of Links MetaPath	115
Number of Shortest Paths	62039
Length Of Smallest Path	3
Average Path Length	14.2853
Length of Longest Path	30
Minimum Path Strength	1.29
Average Path Strength	6.54592
Maximum Path Strength	20.49
Minimum Path Correlation	0.7
Average Path Correlation	0.970007
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	6.25
Average % Of Corr. Nodes	74.1803
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	35.343
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• identical protein binding • protein binding • binding • protein homodimerization activity • protein dimerization activity • amide binding • peptide hormone binding • hormone binding • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • parathyroid hormone receptor activity • developmental process • multicellular organismal process • ossification • bone mineralization • animal organ development • anatomical structure development • biomineral tissue development • tissue development • multicellular organism development • skeletal system development • system development • cell population proliferation • cellular process • cellular response to stimulus
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • ossification • bone mineralization • animal organ development • anatomical structure development • biomineral tissue development • tissue development • multicellular organism development • skeletal system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • osteoblast development • cellular developmental process • cell differentiation • cell development • osteoblast differentiation • embryo development ending in birth or egg hatching • chordate embryonic development • embryo development • in utero embryonic development • anatomical structure maturation • cell maturation • developmental maturation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • cell surface receptor signaling pathway • negative regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • phospholipase C-activating G protein-coupled receptor signaling pathway • connective tissue development • chondrocyte differentiation • cartilage development • regulation of inositol phosphate biosynthetic process • alcohol metabolic process • positive regulation of phosphate metabolic process • inositol phosphate metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • regulation of phosphate metabolic process • phosphate-containing compound metabolic process • polyol biosynthetic process • small molecule metabolic process • phosphorus metabolic process • regulation of carbohydrate metabolic process • regulation of biosynthetic process • carbohydrate metabolic process • polyol metabolic process • positive regulation of phosphorus metabolic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • carbohydrate biosynthetic process • primary metabolic process • positive regulation of inositol phosphate biosynthetic process • biosynthetic process • organophosphate metabolic process • organophosphate biosynthetic process • inositol phosphate biosynthetic process • alcohol biosynthetic process • regulation of phosphorus metabolic process • metabolic process • positive regulation of carbohydrate metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • tissue homeostasis • bone resorption • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • cellular anatomical structure • organelle lumen • organelle • membraneless organelle • nuclear lumen
Gene Ontology	Cellular Component	• membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • cellular anatomical structure • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • apical part of cell • membrane • plasma membrane • plasma membrane region • apical plasma membrane • cytoplasm • cytosol • basal part of cell • basal plasma membrane • basolateral plasma membrane • protein-containing complex • receptor complex • peptide hormone receptor binding • protein binding • binding • corticotropin-releasing hormone receptor binding • signaling receptor binding • G protein-coupled receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • mu-type opioid receptor binding • opioid receptor binding • beta-2 adrenergic receptor binding • adrenergic receptor binding • D1 dopamine receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • ionotropic glutamate receptor binding • glutamate receptor binding • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • insulin-like growth factor receptor binding • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of biological process • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • positive regulation of cellular process • cell division • response to ketone • response to lipid • response to alcohol • cellular response to forskolin • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • midbody • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • cytoskeletal protein binding • spectrin binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to stress • response to oxygen levels • response to abiotic stimulus • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • organelle membrane • cell projection membrane • synapse • cell junction • cell body • G-protein beta-subunit binding • response to prostaglandin • response to endogenous stimulus • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • response to hormone • response to prostaglandin E • cellular response to hormone stimulus
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q03431
Sequence	>6NBF_nogp_Chain_R V M T K E E Q I F L L H R A Q A Q C E K R L K E V G R P C L P E W D H I L C W P L G A P G E V V A V P C P D Y I Y D F N H K G H A Y R R C D R N G S W E L V P G H N R T W A N Y S E C V K F L T N E T R E R E V F D R L A M I Y T V G Y S V S L A S L T V A V L I L A Y F R R L H C T R N Y I H M H L F L S F M L R A V S I F V K D A V L Y S A G Y A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M A F F S E K K Y L W G F T V F G W G L P A V F V A V W V S V R A T L A N T G C W D L S S G N K K W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L R E T N T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M A T P Y T E V S G T L W Q V Q M H Y E M L F N S F Q G F F V A I I Y C F C N G E V Q A E I K K S W S R W T L A L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9JR3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	To be published
	9JR3 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	To be published
	9JR2	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	To be published
	9JR2 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	To be published
	8JR9	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371	chim(NtGi1-Gs)/β1/γ2	2.57	2023-08-02	10.1038/s41586-023-06467-w
	8JR9 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371		2.57	2023-08-02	10.1038/s41586-023-06467-w
	7Y36	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Teriparatide	-	Gs/β1/γ2	2.8	2023-07-05	To be published
	7Y36 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Teriparatide	-		2.8	2023-07-05	To be published
	7Y35	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	2.9	2023-07-05	To be published
	7Y35 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		2.9	2023-07-05	To be published
	8GW8	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	KHF	Gs/β1/γ2	2.9	2023-06-14	10.1038/s41586-023-06169-3
	8GW8 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	KHF		2.9	2023-06-14	10.1038/s41586-023-06169-3
	8FLU	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-	Gs/β1/γ2	2.76	2023-04-26	10.1016/j.str.2023.04.002
	8FLU (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-		2.76	2023-04-26	10.1016/j.str.2023.04.002
	8FLT	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-	Gs/β1/γ2	3.03	2023-04-26	10.1016/j.str.2023.04.002
	8FLT (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-		3.03	2023-04-26	10.1016/j.str.2023.04.002
	8FLS	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	3.09	2023-04-26	10.1016/j.str.2023.04.002
	8FLS (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		3.09	2023-04-26	10.1016/j.str.2023.04.002
	8FLR	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	2.94	2023-04-26	10.1016/j.str.2023.04.002
	8FLR (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		2.94	2023-04-26	10.1016/j.str.2023.04.002
	8FLQ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.55	2023-04-26	10.1016/j.str.2023.04.002
	8FLQ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.55	2023-04-26	10.1016/j.str.2023.04.002
	8HAO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	3.76	2022-12-21	10.1038/s41401-022-01032-z
	8HAO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.76	2022-12-21	10.1038/s41401-022-01032-z
	8HAF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	chim(NtGi1-Gs)/β1/γ2	3.25	2022-12-21	10.1038/s41401-022-01032-z
	8HAF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.25	2022-12-21	10.1038/s41401-022-01032-z
	8HA0	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	2.62	2022-12-21	10.1038/s41401-022-01032-z
	8HA0 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.62	2022-12-21	10.1038/s41401-022-01032-z
	7VVO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	4.1	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		4.1	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVN	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVN (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVM	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVM (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVL	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVL (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVK	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.3	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVK (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.3	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVJ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVJ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	6NBI	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	4	2019-04-17	10.1126/science.aav7942
	6NBI (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		4	2019-04-17	10.1126/science.aav7942
	6NBH	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	3.5	2019-04-17	10.1126/science.aav7942
	6NBH (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		3.5	2019-04-17	10.1126/science.aav7942
	6NBF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	3	2019-04-17	10.1126/science.aav7942
	6NBF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		3	2019-04-17	10.1126/science.aav7942
	6FJ3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	-	2.5	2018-11-21	10.1038/s41594-018-0151-4

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 6NBF_nogp.zip

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