psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:K13	R:R:V31	9.11	No	No	0	0	6
2	R:R:M32	R:R:Y136	3.59	No	No	0	6	4
3	R:R:E36	R:R:T33	7.06	No	No	0	6	7
4	L:L:F23	R:R:K34	4.96	No	No	0	0	4
5	R:R:L41	R:R:Q37	5.32	No	No	0	8	7
6	R:R:I135	R:R:Q37	4.12	Yes	No	0	7	7
7	R:R:A44	R:R:W112	3.89	No	Yes	0	7	7
8	R:R:A44	R:R:Y134	5.34	No	Yes	0	7	5
9	R:R:Q45	R:R:W112	16.43	No	Yes	0	7	7
10	R:R:K50	R:R:Q47	4.07	No	No	0	4	6
11	R:R:C48	R:R:W112	9.14	No	Yes	0	8	7
12	R:R:C117	R:R:C48	7.28	No	No	0	9	8
13	R:R:E54	R:R:R51	5.82	No	No	0	6	6
14	R:R:L52	R:R:P110	3.28	No	Yes	0	4	6
15	R:R:P110	R:R:V55	3.53	Yes	No	6	6	5
16	R:R:L120	R:R:V55	4.47	No	No	6	4	5
17	R:R:C108	R:R:C148	7.28	No	No	0	9	9
18	R:R:C108	R:R:W154	14.37	No	No	0	9	9
19	R:R:L109	R:R:P110	3.28	No	Yes	0	5	6
20	R:R:L120	R:R:P110	3.28	No	Yes	6	4	6
21	R:R:E111	R:R:R146	5.82	No	Yes	2	7	8
22	R:R:E111	R:R:W154	18.54	No	No	2	7	9
23	R:R:H114	R:R:W112	3.17	No	Yes	0	4	7
24	R:R:D113	R:R:W118	11.17	No	Yes	2	9	9
25	R:R:D113	R:R:R146	10.72	No	Yes	2	9	8
26	R:R:D113	R:R:Y167	4.6	No	Yes	2	9	5
27	L:L:L27	R:R:I115	7.14	No	No	0	0	5
28	L:L:I31	R:R:I115	5.89	No	No	0	0	5
29	R:R:L116	R:R:W118	4.56	No	Yes	0	5	9
30	R:R:L116	R:R:P132	9.85	No	No	0	5	9
31	R:R:V129	R:R:W118	7.36	No	Yes	0	5	9
32	R:R:R146	R:R:W118	27.99	Yes	Yes	2	8	9
33	R:R:W118	R:R:Y167	5.79	Yes	Yes	2	9	5
34	R:R:P119	R:R:V127	3.53	No	No	0	6	7
35	R:R:P119	R:R:V129	3.53	No	No	0	6	5
36	R:R:C148	R:R:G121	3.92	No	No	0	9	7
37	R:R:V126	R:R:Y145	3.79	No	No	0	4	4
38	R:R:R147	R:R:V126	3.92	No	No	0	3	4
39	R:R:P130	R:R:V129	3.53	No	No	0	5	5
40	R:R:H143	R:R:P130	9.15	No	No	0	3	5
41	R:R:C131	R:R:C170	7.28	No	No	0	9	9
42	R:R:P132	R:R:Y134	4.17	No	Yes	5	9	5
43	R:R:I135	R:R:P132	5.08	Yes	No	5	7	9
44	R:R:D133	R:R:H140	8.82	No	No	0	2	3
45	R:R:I135	R:R:Y134	4.84	Yes	Yes	5	7	5
46	R:R:F138	R:R:I135	16.33	Yes	Yes	0	4	7
47	R:R:D137	R:R:Y136	4.6	No	No	4	5	4
48	L:L:R20	R:R:Y136	7.2	No	No	4	0	4
49	L:L:R20	R:R:D137	3.57	No	No	4	0	5
50	L:L:R21	R:R:D137	9.53	No	No	0	0	5
51	R:R:F138	R:R:V171	3.93	Yes	No	0	4	3
52	L:L:I28	R:R:F138	5.02	No	Yes	0	0	4
53	R:R:K141	R:R:N139	4.2	No	No	0	3	4
54	R:R:K172	R:R:N139	8.39	No	No	0	3	4
55	R:R:F173	R:R:N139	10.87	No	No	0	3	4
56	R:R:E169	R:R:G142	3.27	No	No	0	5	5
57	R:R:N166	R:R:Y145	3.49	No	No	0	7	4
58	R:R:R146	R:R:W154	6	Yes	No	2	8	9
59	R:R:R146	R:R:T163	6.47	Yes	No	0	8	5
60	R:R:A165	R:R:R146	4.15	No	Yes	2	7	8
61	R:R:R146	R:R:Y167	4.12	Yes	Yes	2	8	5
62	R:R:E155	R:R:R147	15.12	No	No	0	4	3
63	R:R:D149	R:R:N151	5.39	No	No	0	5	5
64	R:R:E155	R:R:W164	8.72	No	No	0	4	5
65	R:R:P158	R:R:V157	3.53	No	Yes	0	4	4
66	R:R:H160	R:R:V157	6.92	No	Yes	0	4	4
67	R:R:A165	R:R:Y167	5.34	No	Yes	2	7	5
68	R:R:N166	R:R:S168	7.45	No	No	0	7	6
69	L:L:I31	R:R:Y167	4.84	No	Yes	0	0	5
70	L:L:H32	R:R:Y167	11.98	No	Yes	0	0	5
71	R:R:E169	R:R:K172	6.75	No	No	0	5	3
72	R:R:N176	R:R:T175	4.39	No	No	0	3	1
73	R:R:N176	R:R:R179	6.03	No	No	0	3	3
74	R:R:R181	R:R:T178	10.35	No	No	0	3	3
75	R:R:E180	R:R:S433	10.06	No	No	0	3	3
76	L:L:W14	R:R:R181	7	No	No	0	0	3
77	R:R:Q438	R:R:V183	8.6	Yes	No	0	4	4
78	R:R:F184	R:R:W437	5.01	No	Yes	0	6	5
79	L:L:R11	R:R:F184	5.34	No	No	0	0	6
80	L:L:W14	R:R:F184	11.02	No	No	0	0	6
81	R:R:H442	R:R:R186	4.51	No	No	0	5	5
82	R:R:L187	R:R:M441	4.24	No	Yes	0	5	6
83	R:R:H442	R:R:L187	7.71	No	No	0	5	5
84	R:R:A188	R:R:Y191	4	No	Yes	0	5	7
85	R:R:I190	R:R:L446	4.28	No	No	0	6	5
86	R:R:D241	R:R:Y191	8.05	No	Yes	0	8	7
87	R:R:M445	R:R:Y191	4.79	No	Yes	0	6	7
88	R:R:G194	R:R:S449	3.71	No	No	0	9	9
89	R:R:R233	R:R:Y195	8.23	Yes	Yes	1	8	7
90	R:R:I237	R:R:Y195	9.67	No	Yes	1	7	7
91	L:L:E4	R:R:Y195	7.86	Yes	Yes	1	0	7
92	R:R:F238	R:R:S196	5.28	No	No	0	7	7
93	R:R:F453	R:R:V197	5.24	No	No	0	6	5
94	R:R:G452	R:R:S198	3.71	No	No	0	9	9
95	R:R:L199	R:R:M231	4.24	No	No	0	7	8
96	R:R:A234	R:R:L199	3.15	No	No	0	8	7
97	R:R:F453	R:R:S201	7.93	No	No	0	6	8
98	R:R:A456	R:R:S201	3.42	No	No	0	8	8
99	R:R:F227	R:R:L202	7.31	Yes	No	0	9	9
100	R:R:F230	R:R:L202	3.65	Yes	No	0	8	9
101	R:R:A456	R:R:L202	3.15	No	No	0	8	9
102	R:R:M231	R:R:T203	6.02	No	No	0	8	3
103	R:R:F461	R:R:V204	3.93	No	No	0	8	5
104	R:R:A205	R:R:C460	3.61	No	No	0	9	9
105	R:R:L228	R:R:V206	4.47	No	No	0	4	5
106	R:R:L209	R:R:M224	4.24	No	No	0	7	5
107	R:R:C460	R:R:L209	3.17	No	No	0	9	7
108	R:R:F212	R:R:Y211	5.16	No	No	0	7	2
109	R:R:F212	R:R:L215	7.31	No	Yes	0	7	9
110	R:R:H216	R:R:R213	3.39	No	No	0	8	8
111	R:R:E469	R:R:R214	9.3	No	No	0	9	7
112	R:R:L215	R:R:V466	4.47	Yes	No	0	9	9
113	R:R:H216	R:R:Y221	4.36	No	No	0	8	7
114	R:R:T218	R:R:Y305	6.24	Yes	Yes	0	7	8
115	R:R:E317	R:R:T218	8.47	No	Yes	0	6	7
116	R:R:N220	R:R:R219	10.85	No	No	0	9	9
117	R:R:E465	R:R:R219	3.49	No	No	0	9	9
118	R:R:H223	R:R:N220	3.83	No	No	0	9	9
119	R:R:E302	R:R:I222	4.1	Yes	No	0	9	9
120	R:R:I222	R:R:Y305	8.46	No	Yes	0	9	8
121	R:R:E302	R:R:H223	8.62	Yes	No	0	9	9
122	R:R:H223	R:R:Y459	5.44	No	No	0	9	8
123	R:R:H225	R:R:W298	14.81	No	Yes	3	8	9
124	R:R:H225	R:R:W329	5.29	No	Yes	3	8	9
125	R:R:F227	R:R:L226	4.87	Yes	No	0	9	9
126	R:R:F230	R:R:L226	8.53	Yes	No	0	8	9
127	R:R:E302	R:R:L226	15.9	Yes	No	0	9	9
128	R:R:S229	R:R:T294	3.2	No	Yes	3	9	8
129	R:R:N295	R:R:S229	5.96	No	No	0	8	9
130	R:R:S229	R:R:W329	3.71	No	Yes	3	9	9
131	R:R:F230	R:R:N295	9.67	Yes	No	0	8	8
132	R:R:F230	R:R:V455	3.93	Yes	No	0	8	9
133	R:R:F291	R:R:L232	18.27	No	No	0	5	8
134	R:R:L292	R:R:R233	6.07	No	Yes	1	6	8
135	R:R:N295	R:R:R233	10.85	No	Yes	0	8	8
136	R:R:R233	R:R:Y296	9.26	Yes	Yes	1	8	7
137	L:L:E4	R:R:R233	11.63	Yes	Yes	1	0	8
138	R:R:F291	R:R:S236	9.25	No	No	0	5	7
139	L:L:E4	R:R:I237	5.47	Yes	No	1	0	7
140	R:R:K240	R:R:L244	5.64	No	No	0	7	5
141	L:L:R11	R:R:L244	4.86	No	No	0	0	5
142	R:R:C281	R:R:C351	7.28	No	No	0	9	9
143	R:R:N348	R:R:R282	4.82	No	No	0	7	8
144	R:R:R282	R:R:W352	22.99	No	Yes	0	8	8
145	R:R:F287	R:R:V283	3.93	No	No	0	3	4
146	R:R:T286	R:R:V340	3.17	No	No	0	7	5
147	L:L:E4	R:R:F288	3.5	Yes	No	0	0	7
148	L:L:M8	R:R:F288	6.22	No	No	0	0	7
149	R:R:L289	R:R:W339	10.25	No	No	0	7	8
150	R:R:I363	R:R:L289	5.71	No	No	0	7	7
151	R:R:F291	R:R:Y290	7.22	No	Yes	0	5	9
152	R:R:T294	R:R:Y290	7.49	Yes	Yes	0	8	9
153	R:R:A333	R:R:Y290	5.34	No	Yes	0	5	9
154	R:R:V336	R:R:Y290	6.31	No	Yes	0	7	9
155	R:R:L292	R:R:Y296	8.21	No	Yes	1	6	7
156	L:L:E4	R:R:L292	6.63	Yes	No	1	0	6
157	R:R:A293	R:R:P332	3.74	No	Yes	0	6	9
158	R:R:A293	R:R:I367	3.25	No	No	0	6	7
159	R:R:T294	R:R:W329	7.28	Yes	Yes	3	8	9
160	R:R:P332	R:R:T294	5.25	Yes	Yes	0	9	8
161	R:R:I367	R:R:Y296	3.63	No	Yes	0	7	7
162	R:R:Y296	R:R:Y421	13.9	Yes	Yes	1	7	8
163	R:R:F327	R:R:Y297	5.16	No	No	0	5	6
164	R:R:P332	R:R:Y297	6.95	Yes	No	0	9	6
165	R:R:F335	R:R:Y297	5.16	No	No	0	5	6
166	R:R:V301	R:R:W298	9.81	No	Yes	0	8	9
167	R:R:G328	R:R:W298	7.04	No	Yes	0	9	9
168	R:R:W298	R:R:W329	18.74	Yes	Yes	3	9	9
169	R:R:I299	R:R:N374	4.25	No	No	0	9	9
170	R:R:F327	R:R:L300	3.65	No	No	0	5	8
171	R:R:L300	R:R:L373	5.54	No	No	0	8	7
172	R:R:F324	R:R:V301	3.93	No	No	0	7	8
173	R:R:E302	R:R:L416	3.98	Yes	No	0	9	9
174	R:R:F417	R:R:G303	4.52	Yes	No	0	9	9
175	R:R:L309	R:R:Y305	15.24	No	Yes	0	8	8
176	R:R:F315	R:R:Y305	4.13	No	Yes	0	6	8
177	R:R:F324	R:R:Y305	5.16	No	Yes	0	7	8
178	R:R:I381	R:R:L306	4.28	No	No	0	9	9
179	R:R:F417	R:R:L306	4.87	Yes	No	0	9	9
180	R:R:F311	R:R:H307	9.05	No	Yes	8	6	8
181	R:R:H307	R:R:L377	9	Yes	No	0	8	7
182	R:R:H307	R:R:N380	8.93	Yes	No	8	8	8
183	R:R:H307	R:R:I381	5.3	Yes	No	0	8	9
184	R:R:F311	R:R:I310	3.77	No	No	0	6	8
185	R:R:F311	R:R:N380	8.46	No	No	8	6	8
186	R:R:F315	R:R:Y320	11.35	No	No	0	6	4
187	R:R:K319	R:R:S316	4.59	No	No	0	6	7
188	R:R:T325	R:R:W322	3.64	No	No	0	5	3
189	R:R:F327	R:R:L331	3.65	No	No	0	5	4
190	R:R:L331	R:R:P332	3.28	No	Yes	0	4	9
191	R:R:F335	R:R:L331	6.09	No	No	0	5	4
192	R:R:F335	R:R:P366	17.34	No	No	0	5	9
193	R:R:W339	R:R:W352	3.75	No	Yes	0	8	8
194	R:R:I362	R:R:W339	7.05	No	No	0	8	8
195	R:R:V340	R:R:W352	4.9	No	Yes	0	5	8
196	R:R:K359	R:R:V342	6.07	No	Yes	0	3	5
197	R:R:I362	R:R:V342	4.61	No	Yes	0	8	5
198	R:R:R343	R:R:W352	17.99	No	Yes	0	8	8
199	R:R:K359	R:R:L346	9.87	No	No	0	3	3
200	L:L:M8	R:R:D353	6.93	No	No	0	0	5
201	L:L:A12	R:R:D353	6.18	No	No	0	0	5
202	L:L:A12	R:R:L354	3.15	No	No	0	0	5
203	L:L:Q16	R:R:L354	7.99	No	No	0	0	5
204	L:L:H9	R:R:S355	6.97	No	No	0	0	7
205	R:R:K359	R:R:S356	7.65	No	No	0	3	4
206	R:R:N358	R:R:W361	3.39	No	Yes	0	4	8
207	R:R:K360	R:R:W361	5.8	No	Yes	0	7	8
208	R:R:K360	R:R:Y429	15.53	No	Yes	0	7	6
209	R:R:Q364	R:R:W361	5.48	Yes	Yes	0	7	8
210	R:R:V365	R:R:W361	4.9	No	Yes	0	5	8
211	R:R:Q364	R:R:Y429	3.38	Yes	Yes	0	7	6
212	L:L:V2	R:R:Q364	8.6	No	Yes	9	0	7
213	L:L:I5	R:R:Q364	5.49	No	Yes	9	0	7
214	R:R:P366	R:R:V365	3.53	No	No	0	9	5
215	R:R:I371	R:R:M425	8.75	No	Yes	0	7	6
216	R:R:F417	R:R:N374	7.25	Yes	No	0	9	9
217	R:R:F375	R:R:I422	11.3	No	No	0	7	5
218	R:R:F378	R:R:V382	7.87	Yes	No	0	9	7
219	R:R:F378	R:R:L413	6.09	Yes	No	7	9	9
220	R:R:F378	R:R:F417	7.5	Yes	Yes	7	9	9
221	R:R:F378	R:R:V419	9.18	Yes	No	0	9	7
222	R:R:N380	R:R:R383	4.82	No	No	0	8	8
223	R:R:E391	R:R:T387	5.64	No	No	0	7	7
224	R:R:L389	R:R:Q402	6.65	No	No	0	8	6
225	R:R:K405	R:R:L389	4.23	No	No	0	8	8
226	R:R:L389	R:R:L406	4.15	No	No	0	8	8
227	R:R:L407	R:R:L411	4.15	No	No	0	8	8
228	R:R:K408	R:R:V412	4.55	No	No	0	8	8
229	R:R:I458	R:R:V412	7.68	No	No	0	8	8
230	R:R:F417	R:R:L413	6.09	Yes	No	7	9	9
231	R:R:M414	R:R:V419	9.13	No	No	0	8	7
232	R:R:F417	R:R:L416	7.31	Yes	No	0	9	9
233	R:R:L416	R:R:Y459	12.89	No	No	0	9	8
234	R:R:G418	R:R:H420	3.18	No	Yes	0	9	8
235	R:R:H420	R:R:Y421	17.42	Yes	Yes	1	8	8
236	R:R:F447	R:R:H420	6.79	No	Yes	0	5	8
237	R:R:H420	R:R:N448	5.1	Yes	No	1	8	6
238	R:R:H420	R:R:Q451	7.42	Yes	No	1	8	9
239	R:R:N448	R:R:Y421	10.47	No	Yes	1	6	8
240	R:R:Q451	R:R:Y421	10.15	No	Yes	1	9	8
241	R:R:I422	R:R:M425	4.37	No	Yes	0	5	6
242	R:R:F424	R:R:V423	6.55	Yes	No	10	7	6
243	R:R:V423	R:R:Y443	10.09	No	Yes	10	6	4
244	R:R:F424	R:R:Q440	9.37	Yes	No	0	7	6
245	R:R:F424	R:R:Y443	7.22	Yes	Yes	10	7	4
246	R:R:Q440	R:R:T427	7.09	No	No	0	6	5
247	L:L:A1	R:R:Y429	4	No	Yes	0	0	6
248	L:L:Q6	R:R:Y429	9.02	No	Yes	0	0	6
249	L:L:Q10	R:R:Y429	3.38	No	Yes	0	0	6
250	R:R:T430	R:R:W437	4.85	No	Yes	0	5	5
251	L:L:Q10	R:R:V432	4.3	No	No	0	0	5
252	R:R:Q438	R:R:W437	3.29	Yes	Yes	0	4	5
253	R:R:M441	R:R:W437	8.14	Yes	Yes	0	6	5
254	L:L:Q10	R:R:W437	5.48	No	Yes	0	0	5
255	R:R:H442	R:R:Q438	3.71	No	Yes	0	5	4
256	L:L:Q6	R:R:Q440	7.68	No	No	0	0	6
257	L:L:Q6	R:R:M441	5.44	No	Yes	0	0	6
258	L:L:L7	R:R:M441	8.48	No	Yes	0	0	6
259	R:R:E444	R:R:Y443	4.49	No	Yes	0	7	4
260	R:R:F447	R:R:Y443	9.28	No	Yes	0	5	4
261	R:R:E444	R:R:N448	7.89	No	No	0	7	6
262	L:L:A3	R:R:E444	6.03	No	No	0	0	7
263	L:L:E4	R:R:M445	4.06	Yes	No	0	0	6
264	R:R:F450	R:R:S449	5.28	No	No	0	7	9
265	R:R:F450	R:R:F454	4.29	No	No	0	7	6
266	R:R:F453	R:R:I457	10.05	No	No	0	6	6
267	R:R:F461	R:R:I457	5.02	No	No	0	8	6
268	R:R:I458	R:R:Y459	8.46	No	No	0	8	8
269	R:R:N463	R:R:V466	5.91	No	No	0	9	9
270	R:R:T478	R:R:W474	6.06	No	No	0	4	5
271	R:R:S475	R:R:T478	3.2	No	No	0	4	4
272	L:L:I5	L:L:V2	10.75	No	No	9	0	0
273	L:L:I15	L:L:R19	3.76	No	No	0	0	0
274	L:L:Q16	L:L:R19	4.67	No	No	0	0	0
275	L:L:D17	L:L:R20	9.53	No	No	0	0	0
276	L:L:D17	L:L:R21	5.96	No	No	0	0	0
277	R:R:I208	R:R:V204	3.07	No	No	0	8	5
278	R:R:M312	R:R:S308	3.07	No	No	0	5	7
279	R:R:I310	R:R:V384	3.07	No	No	0	8	8
280	R:R:I470	R:R:V466	3.07	No	No	0	5	9
281	L:L:K13	R:R:S355	3.06	No	No	0	0	7
282	R:R:K405	R:R:S409	3.06	No	No	0	8	9
283	R:R:K240	R:R:V285	3.04	No	No	0	7	6
284	L:L:M8	R:R:V285	3.04	No	No	0	0	6
285	R:R:M425	R:R:V372	3.04	Yes	No	0	6	4
286	R:R:A122	R:R:E125	3.02	No	No	0	1	5
287	R:R:F230	R:R:G452	3.01	Yes	No	0	8	9
288	R:R:M414	R:R:T410	3.01	No	No	0	8	9
289	R:R:L479	R:R:S475	3	No	No	0	4	4
290	R:R:L199	R:R:V235	2.98	No	No	0	7	4
291	R:R:L289	R:R:V336	2.98	No	No	0	7	7
292	R:R:L346	R:R:T345	2.95	No	No	0	3	3
293	R:R:L406	R:R:T410	2.95	No	No	0	8	9
294	R:R:I190	R:R:M445	2.92	No	No	0	6	6
295	R:R:F454	R:R:P415	2.89	No	No	0	6	9
296	R:R:Q438	R:R:S433	2.89	Yes	No	0	4	3
297	R:R:P107	R:R:R106	2.88	No	No	0	3	1
298	R:R:K50	R:R:K53	2.87	No	No	0	4	5
299	R:R:E169	R:R:S168	2.87	No	No	0	5	6
300	L:L:I28	L:L:L24	2.85	No	No	0	0	0
301	R:R:C170	R:R:F138	2.79	No	Yes	0	9	4
302	R:R:A205	R:R:F227	2.77	No	Yes	0	9	9
303	R:R:L304	R:R:L377	2.77	No	No	0	5	7
304	R:R:A347	R:R:R343	2.77	No	No	0	7	8
305	R:R:H225	R:R:T325	2.74	No	No	0	8	5
306	R:R:A128	R:R:Y145	2.67	No	No	0	5	4
307	R:R:A144	R:R:Y167	2.67	No	Yes	0	7	5
308	R:R:L368	R:R:Q364	2.66	No	Yes	0	4	7
309	R:R:H42	R:R:I38	2.65	No	No	0	4	7
310	R:R:E465	R:R:L215	2.65	No	Yes	0	9	9
311	R:R:E469	R:R:L215	2.65	No	Yes	0	9	9
312	L:L:H9	L:L:I5	2.65	No	No	0	0	0
313	R:R:F315	R:R:S308	2.64	No	No	0	6	7
314	R:R:F227	R:R:V206	2.62	Yes	No	0	9	5
315	R:R:F375	R:R:V419	2.62	No	No	0	7	7
316	R:R:F238	R:R:T192	2.59	No	No	0	7	7
317	R:R:A344	R:R:W352	2.59	No	Yes	0	4	8
318	R:R:R390	R:R:T387	2.59	No	No	0	6	7
319	R:R:S449	R:R:Y195	2.54	No	Yes	0	9	7
320	R:R:S316	R:R:Y320	2.54	No	No	0	7	4
321	R:R:F375	R:R:I379	2.51	No	No	0	7	5
322	R:R:T192	R:R:Y191	2.5	No	Yes	0	7	7
323	L:L:R19	R:R:K34	2.48	No	No	0	0	4
324	R:R:V157	R:R:W164	2.45	Yes	No	0	4	5
325	R:R:L321	R:R:Y221	2.34	No	No	0	6	7
326	L:L:E30	R:R:R162	2.33	No	No	0	0	3
327	R:R:E182	R:R:R186	2.33	No	No	0	2	5
328	R:R:C108	R:R:G152	1.96	No	No	0	9	9
329	R:R:C131	R:R:G142	1.96	No	No	0	9	5
330	R:R:A276	R:R:G350	1.95	No	No	0	4	5
331	R:R:A122	R:R:P123	1.87	No	No	0	1	7
332	R:R:G357	R:R:S356	1.86	No	No	0	6	4
333	R:R:G434	R:R:S433	1.86	No	No	0	5	3
334	R:R:G194	R:R:V193	1.84	No	No	0	9	6
335	R:R:G280	R:R:V283	1.84	No	No	0	4	4
336	R:R:G350	R:R:T349	1.82	No	No	0	5	5
337	R:R:A276	R:R:C351	1.81	No	No	0	4	9
338	R:R:P428	R:R:T427	1.75	No	No	0	7	5
339	R:R:A284	R:R:V243	1.7	No	No	0	6	5
340	R:R:G464	R:R:N463	1.7	No	No	0	7	9
341	R:R:C217	R:R:T218	1.69	No	Yes	0	8	7
342	R:R:D149	R:R:G152	1.68	No	No	0	5	9
343	R:R:A347	R:R:T349	1.68	No	No	0	7	5
344	R:R:L120	R:R:P107	1.64	No	No	0	4	3
345	R:R:S341	R:R:V342	1.62	No	Yes	0	5	5
346	R:R:A210	R:R:M224	1.61	No	No	0	4	5
347	R:R:A284	R:R:K240	1.61	No	No	0	6	7
348	R:R:A426	R:R:M425	1.61	No	Yes	0	5	6
349	R:R:V338	R:R:V342	1.6	No	Yes	0	5	5
350	R:R:C48	R:R:L52	1.59	No	No	0	8	4
351	R:R:I367	R:R:S370	1.55	No	No	0	7	7
352	R:R:I371	R:R:S370	1.55	No	No	0	7	7
353	R:R:I376	R:R:V372	1.54	No	No	0	4	4
354	R:R:M231	R:R:V206	1.52	No	No	0	8	5
355	R:R:G124	R:R:R150	1.5	No	No	0	7	1
356	R:R:G277	R:R:R282	1.5	No	No	0	4	8
357	R:R:L385	R:R:S409	1.5	No	No	0	8	9
358	R:R:L174	R:R:V171	1.49	No	No	0	3	3
359	R:R:D149	R:R:S153	1.47	No	No	0	5	4
360	R:R:L156	R:R:T163	1.47	No	No	0	4	5
361	R:R:L321	R:R:T218	1.47	No	Yes	0	6	7
362	R:R:L436	R:R:T430	1.47	No	No	0	4	5
363	R:R:Q401	R:R:T399	1.42	No	No	0	6	6
364	R:R:Q402	R:R:T399	1.42	No	No	0	6	6
365	R:R:L40	R:R:M32	1.41	No	No	0	5	6
366	R:R:E35	R:R:T33	1.41	No	No	0	5	7
367	R:R:E177	R:R:T178	1.41	No	No	0	1	3
368	R:R:G330	R:R:W329	1.41	No	Yes	0	7	9
369	R:R:L411	R:R:M414	1.41	No	No	0	8	8
370	R:R:E431	R:R:T430	1.41	No	No	0	3	5
371	R:R:L156	R:R:N161	1.37	No	No	0	4	7
372	R:R:E36	R:R:M32	1.35	No	No	0	6	6
373	R:R:F212	R:R:S473	1.32	No	No	0	7	4
374	R:R:R162	R:R:V157	1.31	No	Yes	0	3	4
375	R:R:E180	R:R:N176	1.31	No	No	0	3	3
376	R:R:F424	R:R:V439	1.31	Yes	No	0	7	5
377	R:R:H42	R:R:Q45	1.24	No	No	0	4	7
378	R:R:D185	R:R:R181	1.19	No	No	0	2	3
379	R:R:L40	R:R:Y134	1.17	No	Yes	0	5	5
380	R:R:Q402	R:R:R390	1.17	No	No	0	6	6
381	R:R:K318	R:R:W322	1.16	No	No	0	5	3
382	R:R:L481	R:R:W477	1.14	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:P110	3.3425	4	6	6
2	R:R:W112	8.1575	4	0	7
3	R:R:W118	11.374	5	2	9
4	R:R:Y134	3.88	4	5	5
5	R:R:I135	7.5925	4	5	7
6	R:R:F138	7.0175	4	0	4
7	R:R:R146	9.32429	7	2	8
8	R:R:V157	3.5525	4	0	4
9	R:R:Y167	5.62	7	2	5
10	R:R:Y191	4.835	4	0	7
11	R:R:Y195	7.075	4	1	7
12	R:R:L215	4.27	4	0	9
13	R:R:T218	4.4675	4	0	7
14	R:R:F227	4.3925	4	0	9
15	R:R:F230	5.758	5	0	8
16	R:R:R233	9.208	5	1	8
17	R:R:Y290	6.59	4	0	9
18	R:R:T294	5.805	4	3	8
19	R:R:Y296	8.75	4	1	7
20	R:R:W298	12.6	4	3	9
21	R:R:E302	8.15	4	0	9
22	R:R:Y305	7.846	5	0	8
23	R:R:H307	8.07	4	8	8
24	R:R:W329	7.286	5	3	9
25	R:R:P332	4.805	4	0	9
26	R:R:V342	3.475	4	0	5
27	R:R:W352	10.444	5	0	8
28	R:R:W361	4.8925	4	0	8
29	R:R:Q364	5.122	5	9	7
30	R:R:F378	7.66	4	7	9
31	R:R:F417	6.25667	6	7	9
32	R:R:H420	7.982	5	1	8
33	R:R:Y421	12.985	4	1	8
34	R:R:F424	6.1125	4	10	7
35	R:R:M425	4.4425	4	0	6
36	R:R:Y429	7.062	5	0	6
37	R:R:W437	5.354	5	0	5
38	R:R:Q438	4.6225	4	0	4
39	R:R:M441	6.575	4	0	6
40	R:R:Y443	7.77	4	10	4
41	L:L:E4	6.525	6	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:A12	R:R:L354	11.1736	3.15	No	No	0	0	5
2	L:L:A12	R:R:D353	13.0012	6.18	No	No	0	0	5
3	L:L:M8	R:R:D353	14.8188	6.93	No	No	0	0	5
4	L:L:M8	R:R:V285	29.1211	3.04	No	No	0	0	6
5	R:R:K240	R:R:V285	27.8554	3.04	No	No	0	7	6
6	R:R:K240	R:R:L244	24.2558	5.64	No	No	0	7	5
7	L:L:R11	R:R:L244	23.1926	4.86	No	No	0	0	5
8	L:L:R11	R:R:F184	22.3117	5.34	No	No	0	0	6
9	R:R:F184	R:R:W437	21.2181	5.01	No	Yes	0	6	5
10	L:L:Q10	R:R:W437	30.4324	5.48	No	Yes	0	0	5
11	L:L:Q10	R:R:Y429	38.8467	3.38	No	Yes	0	0	6
12	R:R:Q364	R:R:Y429	32.5081	3.38	Yes	Yes	0	7	6
13	L:L:I5	R:R:Q364	15.4364	5.49	No	Yes	9	0	7
14	L:L:H9	L:L:I5	12.3886	2.65	No	No	0	0	0
15	R:R:Q438	R:R:W437	26.7872	3.29	Yes	Yes	0	4	5
16	R:R:Q438	R:R:S433	15.3959	2.89	Yes	No	0	4	3
17	R:R:E180	R:R:S433	10.3028	10.06	No	No	0	3	3
18	L:L:W14	R:R:F184	11.7659	11.02	No	No	0	0	6
19	L:L:Q6	R:R:Y429	22.3471	9.02	No	Yes	0	0	6
20	L:L:Q6	R:R:M441	22.5243	5.44	No	Yes	0	0	6
21	R:R:L187	R:R:M441	11.6798	4.24	No	Yes	0	5	6
22	R:R:H442	R:R:R186	10.1205	4.51	No	No	0	5	5
23	R:R:Q364	R:R:W361	45.6308	5.48	Yes	Yes	0	7	8
24	R:R:V365	R:R:W361	78.0883	4.9	No	Yes	0	5	8
25	R:R:P366	R:R:V365	80.1185	3.53	No	No	0	9	5
26	R:R:F335	R:R:P366	82.3208	17.34	No	No	0	5	9
27	R:R:F335	R:R:Y297	42.335	5.16	No	No	0	5	6
28	R:R:P332	R:R:Y297	46.2839	6.95	Yes	No	0	9	6
29	R:R:A293	R:R:P332	27.3188	3.74	No	Yes	0	6	9
30	R:R:A293	R:R:I367	26.9694	3.25	No	No	0	6	7
31	R:R:I367	R:R:Y296	35.8951	3.63	No	Yes	0	7	7
32	R:R:R233	R:R:Y296	46.2991	9.26	Yes	Yes	1	8	7
33	L:L:E4	R:R:R233	49.5494	11.63	Yes	Yes	1	0	8
34	L:L:E4	R:R:M445	21.9117	4.06	Yes	No	0	0	6
35	R:R:M445	R:R:Y191	14.6972	4.79	No	Yes	0	6	7
36	R:R:F335	R:R:L331	42.335	6.09	No	No	0	5	4
37	R:R:L331	R:R:P332	46.2839	3.28	No	Yes	0	4	9
38	L:L:Q6	R:R:Q440	27.8807	7.68	No	No	0	0	6
39	R:R:F424	R:R:Q440	32.1031	9.37	Yes	No	0	7	6
40	R:R:F424	R:R:Y443	36.5634	7.22	Yes	Yes	10	7	4
41	R:R:E444	R:R:Y443	20.7928	4.49	No	Yes	0	7	4
42	R:R:E444	R:R:N448	23.1015	7.89	No	No	0	7	6
43	R:R:N448	R:R:Y421	24.2355	10.47	No	Yes	1	6	8
44	R:R:Y296	R:R:Y421	50.8303	13.9	Yes	Yes	1	7	8
45	R:R:F447	R:R:Y443	21.0308	9.28	No	Yes	0	5	4
46	R:R:F447	R:R:H420	22.175	6.79	No	Yes	0	5	8
47	R:R:H420	R:R:Y421	24.2406	17.42	Yes	Yes	1	8	8
48	R:R:P332	R:R:T294	85.1306	5.25	Yes	Yes	0	9	8
49	R:R:S229	R:R:T294	55.9842	3.2	No	Yes	3	9	8
50	R:R:N295	R:R:S229	62.9	5.96	No	No	0	8	9
51	R:R:N295	R:R:R233	77.015	10.85	No	Yes	0	8	8
52	R:R:L292	R:R:Y296	12.0595	8.21	No	Yes	1	6	7
53	L:L:E4	R:R:L292	11.7051	6.63	Yes	No	1	0	6
54	L:L:M8	R:R:F288	40.9224	6.22	No	No	0	0	7
55	L:L:E4	R:R:F288	42.3299	3.5	Yes	No	0	0	7
56	R:R:R233	R:R:Y195	12.6772	8.23	Yes	Yes	1	8	7
57	R:R:S449	R:R:Y195	11.2039	2.54	No	Yes	0	9	7
58	R:R:F230	R:R:N295	100	9.67	Yes	No	0	8	8
59	R:R:F230	R:R:L202	27.4757	3.65	Yes	No	0	8	9
60	R:R:A456	R:R:L202	15.6288	3.15	No	No	0	8	9
61	R:R:A456	R:R:S201	13.71	3.42	No	No	0	8	8
62	R:R:F453	R:R:S201	11.7811	7.93	No	No	0	6	8
63	R:R:F227	R:R:L202	18.226	7.31	Yes	No	0	9	9
64	R:R:F227	R:R:V206	18.6361	2.62	Yes	No	0	9	5
65	R:R:M231	R:R:V206	13.3607	1.52	No	No	0	8	5
66	R:R:F230	R:R:L226	77.6124	8.53	Yes	No	0	8	9
67	R:R:F227	R:R:L226	23.0964	4.87	Yes	No	0	9	9
68	R:R:A205	R:R:F227	13.3607	2.77	No	Yes	0	9	9
69	R:R:A205	R:R:C460	10.7078	3.61	No	No	0	9	9
70	R:R:E302	R:R:L226	71.7092	15.9	Yes	No	0	9	9
71	R:R:E302	R:R:H223	27.096	8.62	Yes	No	0	9	9
72	R:R:H223	R:R:N220	23.2787	3.83	No	No	0	9	9
73	R:R:N220	R:R:R219	21.5472	10.85	No	No	0	9	9
74	R:R:E465	R:R:R219	19.8056	3.49	No	No	0	9	9
75	R:R:E465	R:R:L215	18.0539	2.65	No	Yes	0	9	9
76	R:R:T294	R:R:W329	23.2938	7.28	Yes	Yes	3	8	9
77	R:R:W298	R:R:W329	19.8005	18.74	Yes	Yes	3	9	9
78	R:R:V301	R:R:W298	19.112	9.81	No	Yes	0	8	9
79	R:R:F324	R:R:V301	18.1956	3.93	No	No	0	7	8
80	R:R:F324	R:R:Y305	17.4716	5.16	No	Yes	0	7	8
81	R:R:T218	R:R:Y305	14.0998	6.24	Yes	Yes	0	7	8
82	R:R:E302	R:R:I222	19.3297	4.1	Yes	No	0	9	9
83	R:R:I222	R:R:Y305	18.3829	8.46	No	Yes	0	9	8
84	R:R:E302	R:R:L416	45.5093	3.98	Yes	No	0	9	9
85	R:R:T294	R:R:Y290	68.0387	7.49	Yes	Yes	0	8	9
86	R:R:V336	R:R:Y290	58.0903	6.31	No	Yes	0	7	9
87	R:R:L289	R:R:V336	56.0703	2.98	No	No	0	7	7
88	R:R:L289	R:R:W339	51.9998	10.25	No	No	0	7	8
89	R:R:W339	R:R:W352	31.0399	3.75	No	Yes	0	8	8
90	R:R:R343	R:R:W352	15.7655	17.99	No	Yes	0	8	8
91	R:R:A347	R:R:R343	13.5429	2.77	No	No	0	7	8
92	R:R:A347	R:R:T349	11.3102	1.68	No	No	0	7	5
93	R:R:F417	R:R:L416	42.7248	7.31	Yes	No	0	9	9
94	R:R:F315	R:R:Y305	12.1152	4.13	No	Yes	0	6	8
95	R:R:F417	R:R:L306	16.692	4.87	Yes	No	0	9	9
96	R:R:I381	R:R:L306	15.077	4.28	No	No	0	9	9
97	R:R:H307	R:R:I381	13.4417	5.3	Yes	No	0	8	9
98	R:R:I362	R:R:W339	20.1802	7.05	No	No	0	8	8
99	R:R:I362	R:R:V342	17.9779	4.61	No	Yes	0	8	5
100	R:R:K359	R:R:V342	11.3102	6.07	No	Yes	0	3	5
101	R:R:K360	R:R:W361	29.1515	5.8	No	Yes	0	7	8
102	R:R:K360	R:R:Y429	27.5111	15.53	No	Yes	0	7	6
103	R:R:I367	R:R:S370	33.0093	1.55	No	No	0	7	7
104	R:R:I371	R:R:S370	31.5158	1.55	No	No	0	7	7
105	R:R:I371	R:R:M425	30.2855	8.75	No	Yes	0	7	6
106	R:R:I422	R:R:M425	26.4986	4.37	No	Yes	0	5	6
107	R:R:F375	R:R:I422	25.7847	11.3	No	No	0	7	5
108	R:R:F375	R:R:V419	24.5089	2.62	No	No	0	7	7
109	R:R:F378	R:R:V419	20.6207	9.18	Yes	No	0	9	7
110	R:R:F378	R:R:F417	22.3269	7.5	Yes	Yes	7	9	9
111	R:R:M414	R:R:V419	33.1814	9.13	No	No	0	8	7
112	R:R:M414	R:R:T410	26.7264	3.01	No	No	0	8	9
113	R:R:L406	R:R:T410	24.5545	2.95	No	No	0	8	9
114	R:R:L389	R:R:L406	22.3724	4.15	No	No	0	8	8
115	R:R:L389	R:R:Q402	13.5429	6.65	No	No	0	8	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:K13	R:R:V31	9.11	0	No	No	0	6	0	1
R:R:M32	R:R:Y136	3.59	0	No	No	6	4	2	1
L:L:F23	R:R:K34	4.96	0	No	No	0	4	0	1
R:R:D113	R:R:W118	11.17	2	No	Yes	9	9	2	2
R:R:D113	R:R:R146	10.72	2	No	Yes	9	8	2	2
R:R:D113	R:R:Y167	4.6	2	No	Yes	9	5	2	1
L:L:L27	R:R:I115	7.14	0	No	No	0	5	0	1
L:L:I31	R:R:I115	5.89	0	No	No	0	5	0	1
R:R:R146	R:R:W118	27.99	2	Yes	Yes	8	9	2	2
R:R:W118	R:R:Y167	5.79	2	Yes	Yes	9	5	2	1
R:R:F138	R:R:I135	16.33	0	Yes	Yes	4	7	1	2
R:R:D137	R:R:Y136	4.6	4	No	No	5	4	1	1
L:L:R20	R:R:Y136	7.2	4	No	No	0	4	0	1
L:L:R20	R:R:D137	3.57	4	No	No	0	5	0	1
L:L:R21	R:R:D137	9.53	0	No	No	0	5	0	1
R:R:F138	R:R:V171	3.93	0	Yes	No	4	3	1	2
L:L:I28	R:R:F138	5.02	0	No	Yes	0	4	0	1
R:R:A165	R:R:R146	4.15	2	No	Yes	7	8	2	2
R:R:R146	R:R:Y167	4.12	2	Yes	Yes	8	5	2	1
R:R:A165	R:R:Y167	5.34	2	No	Yes	7	5	2	1
L:L:I31	R:R:Y167	4.84	0	No	Yes	0	5	0	1
L:L:H32	R:R:Y167	11.98	0	No	Yes	0	5	0	1
R:R:R181	R:R:T178	10.35	0	No	No	3	3	1	2
L:L:W14	R:R:R181	7	0	No	No	0	3	0	1
R:R:F184	R:R:W437	5.01	0	No	Yes	6	5	1	1
L:L:R11	R:R:F184	5.34	0	No	No	0	6	0	1
L:L:W14	R:R:F184	11.02	0	No	No	0	6	0	1
R:R:L187	R:R:M441	4.24	0	No	Yes	5	6	2	1
R:R:M445	R:R:Y191	4.79	0	No	Yes	6	7	1	2
R:R:R233	R:R:Y195	8.23	1	Yes	Yes	8	7	1	1
R:R:I237	R:R:Y195	9.67	1	No	Yes	7	7	1	1
L:L:E4	R:R:Y195	7.86	1	Yes	Yes	0	7	0	1
R:R:L292	R:R:R233	6.07	1	No	Yes	6	8	1	1
R:R:N295	R:R:R233	10.85	0	No	Yes	8	8	2	1
R:R:R233	R:R:Y296	9.26	1	Yes	Yes	8	7	1	2
L:L:E4	R:R:R233	11.63	1	Yes	Yes	0	8	0	1
L:L:E4	R:R:I237	5.47	1	Yes	No	0	7	0	1
R:R:K240	R:R:L244	5.64	0	No	No	7	5	2	1
L:L:R11	R:R:L244	4.86	0	No	No	0	5	0	1
L:L:E4	R:R:F288	3.5	1	Yes	No	0	7	0	1
L:L:M8	R:R:F288	6.22	0	No	No	0	7	0	1
R:R:L292	R:R:Y296	8.21	1	No	Yes	6	7	1	2
L:L:E4	R:R:L292	6.63	1	Yes	No	0	6	0	1
L:L:M8	R:R:D353	6.93	0	No	No	0	5	0	1
L:L:A12	R:R:D353	6.18	0	No	No	0	5	0	1
L:L:A12	R:R:L354	3.15	0	No	No	0	5	0	1
L:L:Q16	R:R:L354	7.99	0	No	No	0	5	0	1
L:L:H9	R:R:S355	6.97	0	No	No	0	7	0	1
R:R:K360	R:R:W361	5.8	0	No	Yes	7	8	2	2
R:R:K360	R:R:Y429	15.53	0	No	Yes	7	6	2	1
R:R:Q364	R:R:W361	5.48	9	Yes	Yes	7	8	1	2
R:R:Q364	R:R:Y429	3.38	9	Yes	Yes	7	6	1	1
L:L:V2	R:R:Q364	8.6	9	No	Yes	0	7	0	1
L:L:I5	R:R:Q364	5.49	9	No	Yes	0	7	0	1
R:R:F424	R:R:Q440	9.37	10	Yes	No	7	6	2	1
R:R:F424	R:R:Y443	7.22	10	Yes	Yes	7	4	2	2
R:R:Q440	R:R:T427	7.09	0	No	No	6	5	1	2
L:L:A1	R:R:Y429	4	0	No	Yes	0	6	0	1
L:L:Q6	R:R:Y429	9.02	0	No	Yes	0	6	0	1
L:L:Q10	R:R:Y429	3.38	0	No	Yes	0	6	0	1
R:R:T430	R:R:W437	4.85	0	No	Yes	5	5	2	1
L:L:Q10	R:R:V432	4.3	0	No	No	0	5	0	1
R:R:Q438	R:R:W437	3.29	0	Yes	Yes	4	5	2	1
R:R:M441	R:R:W437	8.14	0	Yes	Yes	6	5	1	1
L:L:Q10	R:R:W437	5.48	0	No	Yes	0	5	0	1
L:L:Q6	R:R:Q440	7.68	0	No	No	0	6	0	1
L:L:Q6	R:R:M441	5.44	0	No	Yes	0	6	0	1
L:L:L7	R:R:M441	8.48	0	No	Yes	0	6	0	1
R:R:E444	R:R:Y443	4.49	0	No	Yes	7	4	1	2
R:R:E444	R:R:N448	7.89	0	No	No	7	6	1	2
L:L:A3	R:R:E444	6.03	0	No	No	0	7	0	1
L:L:E4	R:R:M445	4.06	1	Yes	No	0	6	0	1
L:L:K13	R:R:S355	3.06	0	No	No	0	7	0	1
R:R:K240	R:R:V285	3.04	0	No	No	7	6	2	1
L:L:M8	R:R:V285	3.04	0	No	No	0	6	0	1
R:R:I190	R:R:M445	2.92	0	No	No	6	6	2	1
R:R:C170	R:R:F138	2.79	0	No	Yes	9	4	2	1
R:R:A144	R:R:Y167	2.67	0	No	Yes	7	5	2	1
R:R:L368	R:R:Q364	2.66	0	No	Yes	4	7	2	1
R:R:S449	R:R:Y195	2.54	0	No	Yes	9	7	2	1
L:L:R19	R:R:K34	2.48	0	No	No	0	4	0	1
L:L:E30	R:R:R162	2.33	0	No	No	0	3	0	1
R:R:R162	R:R:V157	1.31	0	No	Yes	3	4	1	2
R:R:D185	R:R:R181	1.19	0	No	No	2	3	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6NBF_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.15
Number of Linked Nodes	358
Number of Links	382
Number of Hubs	41
Number of Links mediated by Hubs	162
Number of Communities	10
Number of Nodes involved in Communities	43
Number of Links involved in Communities	53

Path Summary
Number Of Nodes in MetaPath	116
Number Of Links MetaPath	115
Number of Shortest Paths	62039
Length Of Smallest Path	3
Average Path Length	14.2853
Length of Longest Path	30
Minimum Path Strength	1.29
Average Path Strength	6.54592
Maximum Path Strength	20.49
Minimum Path Correlation	0.7
Average Path Correlation	0.970035
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	6.25
Average % Of Corr. Nodes	74.1555
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	35.343
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q03431
Sequence	>6NBF_nogp_Chain_R V M T K E E Q I F L L H R A Q A Q C E K R L K E V G R P C L P E W D H I L C W P L G A P G E V V A V P C P D Y I Y D F N H K G H A Y R R C D R N G S W E L V P G H N R T W A N Y S E C V K F L T N E T R E R E V F D R L A M I Y T V G Y S V S L A S L T V A V L I L A Y F R R L H C T R N Y I H M H L F L S F M L R A V S I F V K D A V L Y S A G Y A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M A F F S E K K Y L W G F T V F G W G L P A V F V A V W V S V R A T L A N T G C W D L S S G N K K W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L R E T N T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M A T P Y T E V S G T L W Q V Q M H Y E M L F N S F Q G F F V A I I Y C F C N G E V Q A E I K K S W S R W T L A L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6FJ3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	-	2.5	2018-11-21	doi.org/10.1038/s41594-018-0151-4
	6NBF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	LA-PTH Analog	-	Gs/β1/γ2	3	2019-04-17	doi.org/10.1126/science.aav7942
	6NBF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	LA-PTH Analog	-		3	2019-04-17	doi.org/10.1126/science.aav7942
	6NBH	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	LA-PTH Analog	-	Gs/β1/γ2	3.5	2019-04-17	doi.org/10.1126/science.aav7942
	6NBH (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	LA-PTH Analog	-		3.5	2019-04-17	doi.org/10.1126/science.aav7942
	6NBI	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	LA-PTH Analog	-	Gs/β1/γ2	4	2019-04-17	doi.org/10.1126/science.aav7942
	6NBI (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	LA-PTH Analog	-		4	2019-04-17	doi.org/10.1126/science.aav7942
	7VVJ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVJ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVK	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.3	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVK (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.3	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVL	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVL (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVM	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVM (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVN	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVN (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	4.1	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		4.1	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	8HA0	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	2.62	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HA0 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.62	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	chim(NtGi1-Gs)/β1/γ2	3.25	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.25	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	3.76	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.76	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8FLQ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.55	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLQ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.55	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLR	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	2.94	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLR (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		2.94	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLS	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	3.09	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLS (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		3.09	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLT	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-	Gs/β1/γ2	3.03	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLT (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-		3.03	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLU	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	LA-PTH Analog	-	Gs/β1/γ2	2.76	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLU (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	LA-PTH Analog	-		2.76	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8GW8	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371	Gs/β1/γ2	2.9	2023-06-14	doi.org/10.1038/s41586-023-06169-3
	8GW8 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371		2.9	2023-06-14	doi.org/10.1038/s41586-023-06169-3
	7Y35	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	2.9	2023-07-05	To be published
	7Y35 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		2.9	2023-07-05	To be published
	7Y36	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.8	2023-07-05	To be published
	7Y36 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2023-07-05	To be published
	8JR9	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371	chim(NtGi1-Gs)/β1/γ2	2.57	2023-08-02	doi.org/10.1038/s41586-023-06467-w
	8JR9 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371		2.57	2023-08-02	doi.org/10.1038/s41586-023-06467-w
	9LXR	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	LA-PTH Analog	-	Arrestin2	3.07	2025-09-10	To be published
	9JR2	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	doi.org/10.1038/s41589-025-01957-6
	9JR2 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	doi.org/10.1038/s41589-025-01957-6
	9JR3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	doi.org/10.1038/s41589-025-01957-6
	9JR3 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	doi.org/10.1038/s41589-025-01957-6
	9B5Y	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	LA-PTH Analog	-	chim(NtGi1-Gq)/β1/γ2	3.49	2025-03-19	doi.org/10.1073/pnas.2426178122
	9B5Y (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	LA-PTH Analog	-		3.49	2025-03-19	doi.org/10.1073/pnas.2426178122
	8YFO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Ac-LA-PTH Analog	-	chim(NtGi1-Gs)/β1/γ2	2.71	2025-09-03	To be published
	8YFO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Ac-LA-PTH Analog	-		2.71	2025-09-03	To be published
	8YG4	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	LA-PTH Analog	-	chim(NtGi1-Gs)/β1/γ2	2.59	2025-09-03	To be published
	8YG4 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	LA-PTH Analog	-		2.59	2025-09-03	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 6NBF_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.