psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:A1	R:R:Q364	4.55	No	Yes	0	0	7
2	L:L:A1	R:R:L368	3.15	No	No	0	0	4
3	L:L:V2	R:R:L292	2.98	No	Yes	0	0	6
4	L:L:V2	R:R:Q364	10.03	No	Yes	0	0	7
5	L:L:V2	R:R:I367	4.61	No	No	0	0	7
6	L:L:S3	R:R:M441	6.13	No	Yes	1	0	6
7	L:L:S3	R:R:E444	8.62	No	Yes	1	0	7
8	L:L:S3	R:R:M445	3.07	No	No	1	0	6
9	L:L:E4	R:R:Y195	5.61	No	Yes	1	0	7
10	L:L:E4	R:R:R233	10.47	No	Yes	1	0	8
11	L:L:E4	R:R:L292	5.3	No	Yes	1	0	6
12	L:L:H5	L:L:H9	20.3	Yes	Yes	1	0	0
13	L:L:H5	R:R:L289	5.14	Yes	Yes	1	0	7
14	L:L:H5	R:R:K360	5.24	Yes	Yes	1	0	7
15	L:L:H5	R:R:Q364	8.65	Yes	Yes	1	0	7
16	L:L:D10	L:L:Q6	7.83	No	No	1	0	0
17	L:L:Q6	R:R:Y429	25.93	No	Yes	1	0	6
18	L:L:Q6	R:R:W437	3.29	No	Yes	1	0	5
19	L:L:L7	R:R:L187	4.15	No	No	0	0	5
20	L:L:L7	R:R:M441	4.24	No	Yes	0	0	6
21	L:L:L8	R:R:K240	5.64	Yes	No	0	0	7
22	L:L:L8	R:R:Y245	4.69	Yes	Yes	4	0	4
23	L:L:L8	R:R:V285	2.98	Yes	No	0	0	6
24	L:L:L8	R:R:D353	9.5	Yes	Yes	4	0	5
25	L:L:H9	R:R:S355	9.76	Yes	No	0	0	7
26	L:L:H9	R:R:K360	6.55	Yes	Yes	1	0	7
27	L:L:H9	R:R:Y429	3.27	Yes	Yes	1	0	6
28	L:L:D10	R:R:V432	4.38	No	No	0	0	5
29	L:L:D10	R:R:W437	5.58	No	Yes	1	0	5
30	L:L:K11	R:R:F184	11.17	No	No	0	0	6
31	L:L:K11	R:R:Y245	16.72	No	Yes	0	0	4
32	L:L:G12	R:R:D353	3.35	No	Yes	0	0	5
33	L:L:K13	R:R:V31	4.55	No	No	0	0	6
34	L:L:S14	R:R:E180	8.62	No	Yes	0	0	3
35	L:L:Q16	L:L:R19	5.84	No	No	0	0	0
36	L:L:Q16	R:R:T33	11.34	No	No	0	0	7
37	L:L:D17	L:L:R20	9.53	No	Yes	0	0	0
38	L:L:R19	R:R:K34	7.43	No	No	6	0	4
39	L:L:R19	R:R:E35	6.98	No	No	6	0	5
40	L:L:R20	R:R:Y136	9.26	Yes	No	0	0	4
41	L:L:R20	R:R:D137	4.76	Yes	No	0	0	5
42	L:L:R21	R:R:D137	14.29	No	No	0	0	5
43	L:L:R21	R:R:F173	5.34	No	No	0	0	3
44	L:L:F23	L:L:H26	4.53	No	No	0	0	0
45	L:L:F23	R:R:K34	4.96	No	No	0	0	4
46	L:L:I31	L:L:L27	4.28	No	No	0	0	0
47	L:L:L27	R:R:H114	5.14	No	Yes	0	0	4
48	L:L:A29	L:L:T33	3.36	No	No	0	0	0
49	L:L:I31	R:R:D113	5.6	No	No	0	0	9
50	L:L:H32	L:L:T33	5.48	Yes	No	0	0	0
51	L:L:H32	L:L:I36	6.63	Yes	No	0	0	0
52	L:L:H32	R:R:Y167	11.98	Yes	Yes	0	0	5
53	L:L:H32	R:R:S168	5.58	Yes	No	0	0	6
54	L:L:E35	R:R:N161	10.52	No	No	0	0	7
55	L:L:E35	R:R:W164	16.36	No	Yes	0	0	5
56	R:R:E36	R:R:M32	4.06	No	No	0	6	6
57	R:R:M32	R:R:Y136	4.79	No	No	0	6	4
58	R:R:E35	R:R:T33	8.47	No	No	0	5	7
59	R:R:E35	R:R:K34	8.1	No	No	6	5	4
60	R:R:L40	R:R:Y134	8.21	No	Yes	0	5	5
61	R:R:H114	R:R:L41	18	Yes	No	0	4	8
62	R:R:L41	R:R:Y134	3.52	No	Yes	0	8	5
63	R:R:A44	R:R:R43	4.15	No	No	7	7	4
64	R:R:R43	R:R:Y134	7.2	No	Yes	7	4	5
65	R:R:A44	R:R:Y134	6.67	No	Yes	7	7	5
66	R:R:E111	R:R:Q45	10.19	No	No	0	7	7
67	R:R:H114	R:R:Q45	3.71	Yes	No	0	4	7
68	R:R:C117	R:R:Q47	3.05	No	No	0	9	6
69	R:R:C48	R:R:E111	7.6	No	No	0	8	7
70	R:R:C117	R:R:C48	7.28	No	No	0	9	8
71	R:R:E49	R:R:K50	4.05	No	No	0	6	4
72	R:R:L120	R:R:R51	4.86	No	No	0	4	6
73	R:R:E54	R:R:L120	5.3	No	No	0	6	4
74	R:R:G105	R:R:P123	4.06	No	No	0	5	7
75	R:R:G152	R:R:R106	4.5	No	No	0	9	1
76	R:R:L109	R:R:P107	4.93	Yes	No	0	5	3
77	R:R:C108	R:R:C148	7.28	No	No	0	9	9
78	R:R:C108	R:R:W154	6.53	No	No	0	9	9
79	R:R:L109	R:R:P110	3.28	Yes	No	0	5	6
80	R:R:L116	R:R:P110	6.57	Yes	No	3	5	6
81	R:R:P110	R:R:P119	3.9	No	Yes	3	6	6
82	R:R:H114	R:R:W112	5.29	Yes	No	0	4	7
83	R:R:D113	R:R:I115	5.6	No	No	3	9	5
84	R:R:D113	R:R:Y167	11.49	No	Yes	3	9	5
85	R:R:I115	R:R:P132	6.77	No	No	0	5	9
86	R:R:I115	R:R:Y167	8.46	No	Yes	3	5	5
87	R:R:L116	R:R:P119	4.93	Yes	Yes	3	5	6
88	R:R:L116	R:R:V129	2.98	Yes	No	0	5	5
89	R:R:L116	R:R:R146	4.86	Yes	Yes	3	5	8
90	R:R:P119	R:R:W118	4.05	Yes	No	0	6	9
91	R:R:V127	R:R:W118	7.36	No	No	0	7	9
92	R:R:V129	R:R:W118	6.13	No	No	0	5	9
93	R:R:E125	R:R:G124	4.91	No	No	0	5	7
94	R:R:P130	R:R:V129	3.53	No	No	0	5	5
95	R:R:C131	R:R:F138	4.19	No	Yes	8	9	4
96	R:R:C131	R:R:C170	5.46	No	No	8	9	9
97	R:R:I135	R:R:Y134	6.04	Yes	Yes	0	7	5
98	R:R:F138	R:R:I135	11.3	Yes	Yes	0	4	7
99	R:R:C170	R:R:F138	6.98	No	Yes	8	9	4
100	R:R:F138	R:R:V171	3.93	Yes	No	0	4	3
101	R:R:K141	R:R:N139	8.39	No	No	0	3	4
102	R:R:K172	R:R:N139	12.59	No	No	0	3	4
103	R:R:G142	R:R:H143	3.18	No	No	0	5	3
104	R:R:H143	R:R:Y145	10.89	No	No	0	3	4
105	R:R:N166	R:R:Y145	6.98	No	No	0	7	4
106	R:R:R146	R:R:T163	9.06	Yes	No	0	8	5
107	R:R:A165	R:R:R146	4.15	No	Yes	3	7	8
108	R:R:R146	R:R:Y167	5.14	Yes	Yes	3	8	5
109	R:R:E155	R:R:R147	12.79	No	No	0	4	3
110	R:R:R147	R:R:W164	8	No	Yes	0	3	5
111	R:R:N151	R:R:R150	10.85	No	No	0	5	1
112	R:R:G159	R:R:L156	3.42	No	No	0	3	4
113	R:R:L156	R:R:R162	3.64	No	No	0	4	3
114	R:R:P158	R:R:V157	7.07	No	No	0	4	4
115	R:R:N161	R:R:P158	13.03	No	No	0	7	4
116	R:R:N166	R:R:W164	4.52	No	Yes	0	7	5
117	R:R:A165	R:R:Y167	6.67	No	Yes	3	7	5
118	R:R:E169	R:R:N166	10.52	No	No	0	5	7
119	R:R:L174	R:R:V171	2.98	No	No	0	3	3
120	R:R:E177	R:R:E180	5.07	No	Yes	0	1	3
121	R:R:E182	R:R:R179	3.49	No	No	0	2	3
122	R:R:R179	R:R:V183	3.92	No	No	0	3	4
123	R:R:E180	R:R:F184	5.83	Yes	No	0	3	6
124	R:R:E180	R:R:V432	8.56	Yes	No	0	3	5
125	R:R:E182	R:R:R186	8.14	No	No	0	2	5
126	R:R:R186	R:R:V183	10.46	No	No	0	5	4
127	R:R:F184	R:R:L187	4.87	No	No	0	6	5
128	R:R:H442	R:R:R186	6.77	No	No	0	5	5
129	R:R:A188	R:R:Y191	4	No	Yes	0	5	7
130	R:R:I190	R:R:L446	5.71	No	No	0	6	5
131	R:R:T192	R:R:Y191	3.75	No	Yes	0	7	7
132	R:R:Y191	R:R:Y195	3.97	Yes	Yes	0	7	7
133	R:R:D241	R:R:Y191	10.34	No	Yes	0	8	7
134	R:R:M445	R:R:Y191	4.79	No	Yes	0	6	7
135	R:R:G194	R:R:S449	3.71	No	No	1	9	9
136	R:R:F450	R:R:G194	7.53	No	No	1	7	9
137	R:R:R233	R:R:Y195	13.38	Yes	Yes	1	8	7
138	R:R:A234	R:R:Y195	4	No	Yes	0	8	7
139	R:R:I237	R:R:Y195	8.46	No	Yes	0	7	7
140	R:R:S449	R:R:Y195	5.09	No	Yes	1	9	7
141	R:R:F238	R:R:S196	6.61	No	No	0	7	7
142	R:R:F453	R:R:V197	3.93	Yes	No	0	6	5
143	R:R:L199	R:R:M231	4.24	No	Yes	0	7	8
144	R:R:L199	R:R:V235	2.98	No	No	0	7	4
145	R:R:F453	R:R:S201	6.61	Yes	No	0	6	8
146	R:R:A456	R:R:S201	3.42	No	No	0	8	8
147	R:R:F227	R:R:L202	4.87	No	Yes	0	9	9
148	R:R:L202	R:R:M231	4.24	Yes	Yes	0	9	8
149	R:R:G452	R:R:L202	5.13	No	Yes	0	9	9
150	R:R:A456	R:R:L202	3.15	No	Yes	0	8	9
151	R:R:M231	R:R:T203	4.52	Yes	No	0	8	3
152	R:R:I208	R:R:V204	3.07	No	No	0	8	5
153	R:R:F461	R:R:V204	3.93	No	No	0	8	5
154	R:R:A205	R:R:C460	3.61	No	No	0	9	9
155	R:R:F227	R:R:V206	3.93	No	No	0	9	5
156	R:R:M231	R:R:V206	3.04	Yes	No	0	8	5
157	R:R:C460	R:R:I208	4.91	No	No	0	9	8
158	R:R:L209	R:R:N220	5.49	No	No	0	7	9
159	R:R:L209	R:R:M224	5.65	No	No	0	7	5
160	R:R:F212	R:R:Y211	5.16	Yes	No	0	7	2
161	R:R:F212	R:R:L215	7.31	Yes	No	0	7	9
162	R:R:E469	R:R:F212	16.32	No	Yes	0	9	7
163	R:R:F212	R:R:I470	5.02	Yes	No	0	7	5
164	R:R:E469	R:R:R214	10.47	No	No	0	9	7
165	R:R:L215	R:R:V466	2.98	No	No	0	9	9
166	R:R:H216	R:R:Y221	7.62	No	No	0	8	7
167	R:R:C217	R:R:N220	3.15	No	No	0	8	9
168	R:R:I222	R:R:T218	3.04	No	Yes	5	9	7
169	R:R:T218	R:R:Y305	4.99	Yes	Yes	5	7	8
170	R:R:E317	R:R:T218	5.64	No	Yes	5	6	7
171	R:R:K318	R:R:T218	3	No	Yes	0	5	7
172	R:R:L321	R:R:T218	4.42	No	Yes	0	6	7
173	R:R:N220	R:R:R219	6.03	No	No	0	9	9
174	R:R:H223	R:R:R219	6.77	No	No	0	9	9
175	R:R:E465	R:R:R219	6.98	No	No	0	9	9
176	R:R:E302	R:R:I222	6.83	Yes	No	0	9	9
177	R:R:I222	R:R:Y305	8.46	No	Yes	5	9	8
178	R:R:E302	R:R:H223	8.62	Yes	No	0	9	9
179	R:R:H225	R:R:W298	13.75	No	Yes	2	8	9
180	R:R:H225	R:R:T325	5.48	No	No	2	8	5
181	R:R:F230	R:R:L226	6.09	Yes	No	9	8	9
182	R:R:I299	R:R:L226	4.28	No	No	9	9	9
183	R:R:E302	R:R:L226	6.63	Yes	No	0	9	9
184	R:R:S229	R:R:T294	3.2	No	Yes	0	9	8
185	R:R:N295	R:R:S229	5.96	No	No	0	8	9
186	R:R:F230	R:R:N295	20.54	Yes	No	0	8	8
187	R:R:F230	R:R:I299	5.02	Yes	No	9	8	9
188	R:R:F230	R:R:Q451	5.86	Yes	No	0	8	9
189	R:R:F230	R:R:G452	3.01	Yes	No	0	8	9
190	R:R:F291	R:R:L232	14.61	No	No	0	5	8
191	R:R:L292	R:R:R233	6.07	Yes	Yes	1	6	8
192	R:R:N295	R:R:R233	10.85	No	Yes	0	8	8
193	R:R:R233	R:R:Y296	5.14	Yes	Yes	1	8	7
194	R:R:N448	R:R:R233	3.62	Yes	Yes	1	6	8
195	R:R:F291	R:R:S236	7.93	No	No	0	5	7
196	R:R:F288	R:R:I237	3.77	No	No	0	7	7
197	R:R:L244	R:R:V243	4.47	Yes	Yes	4	5	5
198	R:R:C281	R:R:V243	3.42	No	Yes	4	9	5
199	R:R:A284	R:R:V243	5.09	No	Yes	0	6	5
200	R:R:L244	R:R:Y245	3.52	Yes	Yes	4	5	4
201	R:R:C281	R:R:L244	3.17	No	Yes	4	9	5
202	R:R:D353	R:R:L244	8.14	Yes	Yes	4	5	5
203	R:R:D353	R:R:Y245	9.2	Yes	Yes	4	5	4
204	R:R:R282	R:R:Y278	6.17	No	No	0	8	4
205	R:R:N348	R:R:R282	4.82	No	No	0	7	8
206	R:R:R282	R:R:W352	22.99	No	Yes	0	8	8
207	R:R:F287	R:R:V283	6.55	No	No	0	3	4
208	R:R:L289	R:R:V285	2.98	Yes	No	0	7	6
209	R:R:T286	R:R:V336	3.17	Yes	No	0	7	7
210	R:R:T286	R:R:V340	3.17	Yes	No	1	7	5
211	R:R:T286	R:R:W352	4.85	Yes	Yes	1	7	8
212	R:R:F288	R:R:L289	6.09	No	Yes	0	7	7
213	R:R:L289	R:R:W339	6.83	Yes	Yes	1	7	8
214	R:R:I363	R:R:L289	4.28	No	Yes	1	7	7
215	R:R:F291	R:R:Y290	5.16	No	Yes	0	5	9
216	R:R:T294	R:R:Y290	8.74	Yes	Yes	2	8	9
217	R:R:W329	R:R:Y290	4.82	No	Yes	2	9	9
218	R:R:A333	R:R:Y290	4	No	Yes	0	5	9
219	R:R:V336	R:R:Y290	5.05	No	Yes	0	7	9
220	R:R:L292	R:R:Y296	4.69	Yes	Yes	1	6	7
221	R:R:T294	R:R:W329	7.28	Yes	No	2	8	9
222	R:R:P332	R:R:T294	3.5	Yes	Yes	2	9	8
223	R:R:I367	R:R:Y296	14.51	No	Yes	0	7	7
224	R:R:Y296	R:R:Y421	21.84	Yes	Yes	1	7	8
225	R:R:F327	R:R:Y297	6.19	No	Yes	0	5	6
226	R:R:L331	R:R:Y297	8.21	No	Yes	2	4	6
227	R:R:P332	R:R:Y297	4.17	Yes	Yes	2	9	6
228	R:R:F335	R:R:Y297	4.13	No	Yes	2	5	6
229	R:R:V301	R:R:W298	3.68	No	Yes	0	8	9
230	R:R:T325	R:R:W298	6.06	No	Yes	2	5	9
231	R:R:W298	R:R:W329	20.62	Yes	No	2	9	9
232	R:R:L300	R:R:L304	6.92	Yes	No	0	8	5
233	R:R:L300	R:R:S370	4.5	Yes	No	0	8	7
234	R:R:L300	R:R:L373	6.92	Yes	No	0	8	7
235	R:R:L300	R:R:N374	5.49	Yes	No	0	8	9
236	R:R:E302	R:R:L416	9.28	Yes	No	0	9	9
237	R:R:F417	R:R:G303	6.02	Yes	No	0	9	9
238	R:R:L304	R:R:L377	4.15	No	No	0	5	7
239	R:R:L309	R:R:Y305	3.52	No	Yes	5	8	8
240	R:R:E317	R:R:Y305	7.86	No	Yes	5	6	8
241	R:R:F324	R:R:Y305	7.22	No	Yes	0	7	8
242	R:R:I381	R:R:L306	5.71	No	No	0	9	9
243	R:R:F311	R:R:H307	19.23	Yes	No	11	6	8
244	R:R:H307	R:R:L377	6.43	No	No	0	8	7
245	R:R:H307	R:R:N380	7.65	No	No	11	8	8
246	R:R:M312	R:R:S308	4.6	No	No	0	5	7
247	R:R:E317	R:R:L309	5.3	No	No	5	6	8
248	R:R:F311	R:R:I310	3.77	Yes	No	0	6	8
249	R:R:F311	R:R:N380	6.04	Yes	No	11	6	8
250	R:R:M312	R:R:Y320	5.99	No	No	0	5	4
251	R:R:F314	R:R:F315	3.22	No	No	0	7	6
252	R:R:F315	R:R:S316	6.61	No	No	0	6	7
253	R:R:K319	R:R:S316	3.06	No	No	0	6	7
254	R:R:S316	R:R:Y320	5.09	No	No	0	7	4
255	R:R:F324	R:R:Y320	3.09	No	No	0	7	4
256	R:R:L331	R:R:P332	3.28	No	Yes	2	4	9
257	R:R:F335	R:R:L331	7.31	No	No	2	5	4
258	R:R:F335	R:R:P366	8.67	No	No	0	5	9
259	R:R:I362	R:R:V338	3.07	No	No	0	8	5
260	R:R:V340	R:R:W339	3.68	No	Yes	1	5	8
261	R:R:W339	R:R:W352	10.31	Yes	Yes	1	8	8
262	R:R:I362	R:R:W339	4.7	No	Yes	0	8	8
263	R:R:I363	R:R:W339	3.52	No	Yes	1	7	8
264	R:R:V340	R:R:W352	6.13	No	Yes	1	5	8
265	R:R:S341	R:R:V342	3.23	No	Yes	0	5	5
266	R:R:L346	R:R:V342	2.98	No	Yes	12	3	5
267	R:R:K359	R:R:V342	4.55	No	Yes	12	3	5
268	R:R:I362	R:R:V342	4.61	No	Yes	0	8	5
269	R:R:R343	R:R:W352	16.99	No	Yes	0	8	8
270	R:R:R343	R:R:S356	5.27	No	No	0	8	4
271	R:R:K359	R:R:L346	7.05	No	No	12	3	3
272	R:R:K359	R:R:S356	7.65	No	No	0	3	4
273	R:R:N358	R:R:W361	5.65	No	Yes	0	4	8
274	R:R:K360	R:R:W361	5.8	Yes	Yes	1	7	8
275	R:R:K360	R:R:Q364	4.07	Yes	Yes	1	7	7
276	R:R:K360	R:R:Y429	14.33	Yes	Yes	1	7	6
277	R:R:Q364	R:R:W361	3.29	Yes	Yes	1	7	8
278	R:R:V365	R:R:W361	3.68	No	Yes	0	5	8
279	R:R:Q364	R:R:Y429	5.64	Yes	Yes	1	7	6
280	R:R:P366	R:R:V365	3.53	No	No	0	9	5
281	R:R:L368	R:R:M425	5.65	No	No	0	4	6
282	R:R:I371	R:R:Y421	9.67	No	Yes	0	7	8
283	R:R:M425	R:R:V372	3.04	No	No	0	6	4
284	R:R:F417	R:R:N374	12.08	Yes	No	0	9	9
285	R:R:G418	R:R:N374	5.09	No	No	0	9	9
286	R:R:F375	R:R:I379	6.28	No	No	0	7	5
287	R:R:F375	R:R:I422	11.3	No	No	0	7	5
288	R:R:F378	R:R:V382	7.87	Yes	No	0	9	7
289	R:R:F378	R:R:L413	8.53	Yes	No	10	9	9
290	R:R:F378	R:R:F417	16.08	Yes	Yes	10	9	9
291	R:R:F378	R:R:V419	6.55	Yes	No	0	9	7
292	R:R:N380	R:R:R383	8.44	No	No	0	8	8
293	R:R:T410	R:R:V382	4.76	No	No	0	9	7
294	R:R:K388	R:R:V384	3.04	No	No	0	9	8
295	R:R:L385	R:R:S409	4.5	No	No	0	8	9
296	R:R:A386	R:R:L406	3.15	No	No	0	6	8
297	R:R:R390	R:R:T387	3.88	No	No	0	6	7
298	R:R:L389	R:R:Q402	3.99	No	No	0	8	6
299	R:R:K405	R:R:L389	5.64	No	No	0	8	8
300	R:R:L389	R:R:L406	4.15	No	No	0	8	8
301	R:R:Q401	R:R:R404	8.18	No	No	0	6	6
302	R:R:K408	R:R:V412	6.07	No	No	0	8	8
303	R:R:F417	R:R:L413	9.74	Yes	No	10	9	9
304	R:R:M414	R:R:P415	3.35	No	No	0	8	9
305	R:R:M414	R:R:V419	7.61	No	No	0	8	7
306	R:R:I458	R:R:P415	5.08	No	No	0	8	9
307	R:R:L416	R:R:Y459	15.24	No	No	0	9	8
308	R:R:H420	R:R:Y421	11.98	Yes	Yes	1	8	8
309	R:R:H420	R:R:Y443	6.53	Yes	Yes	1	8	4
310	R:R:H420	R:R:N448	7.65	Yes	Yes	1	8	6
311	R:R:H420	R:R:Q451	3.71	Yes	No	0	8	9
312	R:R:N448	R:R:Y421	15.12	Yes	Yes	1	6	8
313	R:R:F424	R:R:V423	10.49	Yes	No	1	7	6
314	R:R:V423	R:R:Y443	6.31	No	Yes	1	6	4
315	R:R:F424	R:R:T427	5.19	Yes	No	1	7	5
316	R:R:F424	R:R:Q440	21.08	Yes	No	1	7	6
317	R:R:F424	R:R:Y443	8.25	Yes	Yes	1	7	4
318	R:R:E444	R:R:F424	3.5	Yes	Yes	1	7	7
319	R:R:Q440	R:R:T427	7.09	No	No	1	6	5
320	R:R:T430	R:R:W437	3.64	No	Yes	0	5	5
321	R:R:Q438	R:R:W437	3.29	No	Yes	0	4	5
322	R:R:M441	R:R:W437	16.29	Yes	Yes	1	6	5
323	R:R:M441	R:R:M445	4.33	Yes	No	1	6	6
324	R:R:E444	R:R:Y443	5.61	Yes	Yes	1	7	4
325	R:R:F447	R:R:Y443	12.38	No	Yes	0	5	4
326	R:R:E444	R:R:N448	10.52	Yes	Yes	1	7	6
327	R:R:F447	R:R:L446	4.87	No	No	0	5	5
328	R:R:F450	R:R:S449	5.28	No	No	1	7	9
329	R:R:F450	R:R:F454	6.43	No	No	0	7	6
330	R:R:F453	R:R:F454	5.36	Yes	No	0	6	6
331	R:R:F453	R:R:I457	8.79	Yes	No	0	6	6
332	R:R:F461	R:R:I457	3.77	No	No	0	8	6
333	R:R:I458	R:R:Y459	12.09	No	No	0	8	8
334	R:R:C460	R:R:F461	4.19	No	No	0	9	8
335	R:R:N463	R:R:V466	4.43	No	No	0	9	9
336	R:R:R476	R:R:W477	4	No	No	0	7	4
337	R:R:L406	R:R:T410	2.95	No	No	0	8	9
338	R:R:D149	R:R:S153	2.94	No	No	0	5	4
339	R:R:G350	R:R:Y278	2.9	No	No	0	5	4
340	R:R:K50	R:R:K53	2.87	No	No	0	4	5
341	R:R:I381	R:R:L385	2.85	No	No	0	9	8
342	R:R:I381	R:R:L413	2.85	No	No	0	9	9
343	R:R:E391	R:R:T387	2.82	No	No	0	7	7
344	R:R:G328	R:R:W298	2.81	No	Yes	0	9	9
345	R:R:L109	R:R:L52	2.77	Yes	No	0	5	4
346	R:R:L109	R:R:L120	2.77	Yes	No	0	5	4
347	R:R:L407	R:R:L411	2.77	No	No	0	8	8
348	L:L:E30	L:L:I31	2.73	No	No	0	0	0
349	R:R:D353	R:R:L354	2.71	Yes	No	0	5	5
350	R:R:A144	R:R:Y167	2.67	No	Yes	0	7	5
351	L:L:Q16	R:R:L354	2.66	No	No	0	0	5
352	R:R:E465	R:R:L215	2.65	No	No	0	9	9
353	L:L:S14	R:R:R181	2.64	No	No	0	0	3
354	R:R:F212	R:R:S473	2.64	Yes	No	0	7	4
355	R:R:F311	R:R:V384	2.62	Yes	No	0	6	8
356	R:R:F238	R:R:T192	2.59	No	No	0	7	7
357	R:R:F287	R:R:T286	2.59	No	Yes	0	3	7
358	L:L:H26	L:L:L27	2.57	No	No	0	0	0
359	R:R:S198	R:R:Y195	2.54	No	Yes	0	9	7
360	R:R:V455	R:R:Y459	2.52	No	No	0	9	8
361	L:L:F23	R:R:I38	2.51	No	No	0	0	7
362	R:R:K50	R:R:R51	2.48	No	No	0	4	6
363	R:R:H442	R:R:Q438	2.47	No	No	0	5	4
364	L:L:L18	R:R:R181	2.43	No	No	0	0	3
365	L:L:I15	R:R:Y245	2.42	No	Yes	0	0	4
366	R:R:D185	R:R:R181	2.38	No	No	0	2	3
367	L:L:I36	R:R:W164	2.35	No	Yes	0	0	5
368	L:L:R20	R:R:Q37	2.34	Yes	No	0	0	7
369	R:R:Q402	R:R:R390	2.34	No	No	0	6	6
370	R:R:R400	R:R:R404	2.13	No	No	0	8	6
371	R:R:R162	R:R:W154	2	No	No	0	3	9
372	R:R:A122	R:R:G121	1.95	No	No	0	1	7
373	R:R:A276	R:R:G277	1.95	No	No	0	4	4
374	R:R:A279	R:R:G280	1.95	No	No	0	4	4
375	R:R:A333	R:R:G330	1.95	No	No	0	5	7
376	R:R:A122	R:R:P123	1.87	No	No	0	1	7
377	R:R:A293	R:R:P332	1.87	No	Yes	0	6	9
378	R:R:G434	R:R:S433	1.86	No	No	0	5	3
379	R:R:G194	R:R:V193	1.84	No	No	0	9	6
380	R:R:C281	R:R:C351	1.82	No	No	0	9	9
381	R:R:G350	R:R:T349	1.82	No	No	0	5	5
382	R:R:P119	R:R:V126	1.77	Yes	No	0	6	4
383	R:R:P428	R:R:T427	1.75	No	No	0	7	5
384	R:R:A313	R:R:S308	1.71	No	No	0	7	7
385	R:R:A347	R:R:S356	1.71	No	No	0	7	4
386	R:R:D149	R:R:G124	1.68	No	No	0	5	7
387	R:R:L156	R:R:P158	1.64	No	No	0	4	4
388	R:R:C462	R:R:I457	1.64	No	No	0	6	6
389	R:R:A426	R:R:M425	1.61	No	No	0	5	6
390	R:R:V239	R:R:V243	1.6	No	Yes	0	5	5
391	R:R:V334	R:R:V338	1.6	No	No	0	4	5
392	R:R:G159	R:R:H160	1.59	No	No	0	3	4
393	L:L:A34	R:R:N161	1.56	No	No	0	0	7
394	R:R:A344	R:R:N348	1.56	No	No	0	4	7
395	R:R:I376	R:R:V372	1.54	No	No	0	4	4
396	R:R:I458	R:R:V412	1.54	No	No	0	8	8
397	R:R:I422	R:R:V423	1.54	No	No	0	5	6
398	L:L:I28	L:L:T33	1.52	No	No	0	0	0
399	R:R:M189	R:R:T192	1.51	No	No	0	4	7
400	R:R:N151	R:R:S153	1.49	No	No	0	5	4
401	R:R:L228	R:R:V206	1.49	No	No	0	4	5
402	R:R:C131	R:R:H140	1.47	No	No	0	9	3
403	R:R:L174	R:R:T175	1.47	No	No	0	3	1
404	R:R:L346	R:R:T345	1.47	No	No	0	3	3
405	R:R:L436	R:R:T430	1.47	No	No	0	4	5
406	L:L:D17	R:R:V31	1.46	No	No	0	0	6
407	R:R:A128	R:R:H143	1.46	No	No	0	5	3
408	R:R:P107	R:R:R106	1.44	No	No	0	3	1
409	L:L:I28	L:L:L24	1.43	No	No	0	0	0
410	L:L:L24	R:R:I135	1.43	No	Yes	0	0	7
411	R:R:Q401	R:R:T399	1.42	No	No	0	6	6
412	R:R:Q402	R:R:T399	1.42	No	No	0	6	6
413	R:R:E431	R:R:T430	1.41	No	No	0	3	5
414	R:R:A480	R:R:R476	1.38	No	No	0	4	7
415	R:R:I135	R:R:Q37	1.37	Yes	No	0	7	7
416	R:R:E469	R:R:K472	1.35	No	No	0	9	7
417	R:R:H42	R:R:I38	1.33	No	No	0	4	7
418	R:R:E177	R:R:N176	1.31	No	No	0	1	3
419	R:R:D133	R:R:H140	1.26	No	No	0	2	3
420	R:R:F39	R:R:L40	1.22	No	No	0	7	5
421	L:L:H25	L:L:H26	1.19	No	No	0	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:H5	9.8325	4	1	0
2	L:L:L8	5.7025	4	4	0
3	L:L:H9	9.97	4	1	0
4	L:L:R20	6.4725	4	0	0
5	L:L:H32	7.4175	4	0	0
6	R:R:L109	3.4375	4	0	5
7	R:R:H114	8.035	4	0	4
8	R:R:L116	4.835	4	3	5
9	R:R:P119	3.6625	4	3	6
10	R:R:Y134	6.328	5	7	5
11	R:R:I135	5.035	4	0	7
12	R:R:F138	6.6	4	8	4
13	R:R:R146	5.8025	4	3	8
14	R:R:W164	7.8075	4	0	5
15	R:R:Y167	7.735	6	3	5
16	R:R:E180	7.02	4	0	3
17	R:R:Y191	5.37	5	0	7
18	R:R:Y195	6.15	7	1	7
19	R:R:L202	4.3475	4	0	9
20	R:R:F212	7.29	5	0	7
21	R:R:T218	4.218	5	5	7
22	R:R:F230	8.104	5	9	8
23	R:R:M231	4.01	4	0	8
24	R:R:R233	8.255	6	1	8
25	R:R:V243	3.645	4	4	5
26	R:R:L244	4.825	4	4	5
27	R:R:Y245	7.31	5	4	4
28	R:R:T286	3.445	4	1	7
29	R:R:L289	5.064	5	1	7
30	R:R:Y290	5.554	5	2	9
31	R:R:L292	4.76	4	1	6
32	R:R:T294	5.68	4	2	8
33	R:R:Y296	11.545	4	1	7
34	R:R:Y297	5.675	4	2	6
35	R:R:W298	9.384	5	2	9
36	R:R:L300	5.9575	4	0	8
37	R:R:E302	7.84	4	0	9
38	R:R:Y305	6.41	5	5	8
39	R:R:F311	7.915	4	11	6
40	R:R:P332	3.205	4	2	9
41	R:R:W339	5.808	5	1	8
42	R:R:V342	3.8425	4	12	5
43	R:R:W352	12.254	5	1	8
44	R:R:D353	6.58	5	4	5
45	R:R:K360	7.198	5	1	7
46	R:R:W361	4.605	4	1	8
47	R:R:Q364	6.03833	6	1	7
48	R:R:F378	9.7575	4	10	9
49	R:R:F417	10.98	4	10	9
50	R:R:H420	7.4675	4	1	8
51	R:R:Y421	14.6525	4	1	8
52	R:R:F424	9.702	5	1	7
53	R:R:Y429	12.2925	4	1	6
54	R:R:W437	6.418	5	1	5
55	R:R:M441	7.7475	4	1	6
56	R:R:Y443	7.816	5	1	4
57	R:R:E444	7.0625	4	1	7
58	R:R:N448	9.2275	4	1	6
59	R:R:F453	6.1725	4	0	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:V2	R:R:Q364	18.5133	10.03	No	Yes	0	0	7
2	L:L:V2	R:R:L292	15.895	2.98	No	Yes	0	0	6
3	L:L:Q6	R:R:Y429	12.9672	25.93	No	Yes	1	0	6
4	R:R:M441	R:R:W437	33.9047	16.29	Yes	Yes	1	6	5
5	L:L:S3	R:R:M441	38.5558	6.13	No	Yes	1	0	6
6	R:R:L292	R:R:R233	12.6001	6.07	Yes	Yes	1	6	8
7	R:R:N448	R:R:R233	21.4593	3.62	Yes	Yes	1	6	8
8	R:R:E444	R:R:N448	26.5413	10.52	Yes	Yes	1	7	6
9	R:R:M441	R:R:M445	14.5631	4.33	Yes	No	1	6	6
10	R:R:R233	R:R:Y195	67.7579	13.38	Yes	Yes	1	8	7
11	L:L:H5	R:R:Q364	15.1123	8.65	Yes	Yes	1	0	7
12	L:L:H5	R:R:L289	24.8847	5.14	Yes	Yes	1	0	7
13	L:L:L7	R:R:M441	27.5334	4.24	No	Yes	0	0	6
14	L:L:L7	R:R:L187	26.0467	4.15	No	No	0	0	5
15	R:R:L289	R:R:V285	93.2403	2.98	Yes	No	0	7	6
16	L:L:L8	R:R:V285	92.7275	2.98	Yes	No	0	0	6
17	L:L:L8	R:R:D353	83.6195	9.5	Yes	Yes	4	0	5
18	L:L:D10	R:R:V432	20.27	4.38	No	No	0	0	5
19	L:L:K11	R:R:Y245	22.6123	16.72	No	Yes	0	0	4
20	R:R:E180	R:R:V432	18.3404	8.56	Yes	No	0	3	5
21	R:R:E180	R:R:F184	18.6802	5.83	Yes	No	0	3	6
22	R:R:D353	R:R:L354	99.0261	2.71	Yes	No	0	5	5
23	L:L:Q16	R:R:L354	98.4102	2.66	No	No	0	0	5
24	L:L:Q16	L:L:R19	95.9102	5.84	No	No	0	0	0
25	L:L:R19	R:R:K34	94.3295	7.43	No	No	6	0	4
26	L:L:F23	R:R:K34	94.287	4.96	No	No	0	0	4
27	L:L:F23	L:L:H26	92.2876	4.53	No	No	0	0	0
28	L:L:H26	L:L:L27	90.9345	2.57	No	No	0	0	0
29	L:L:L27	R:R:H114	35.9921	5.14	No	Yes	0	0	4
30	R:R:H114	R:R:L41	28.6286	18	Yes	No	0	4	8
31	R:R:L41	R:R:Y134	27.6244	3.52	No	Yes	0	8	5
32	R:R:I135	R:R:Y134	23.3131	6.04	Yes	Yes	0	7	5
33	R:R:I135	R:R:Q37	13.4132	1.37	Yes	No	0	7	7
34	L:L:R20	R:R:Q37	12.2239	2.34	Yes	No	0	0	7
35	L:L:S14	R:R:E180	15.2518	8.62	No	Yes	0	0	3
36	L:L:I31	L:L:L27	58.3131	4.28	No	No	0	0	0
37	L:L:I31	R:R:D113	56.4988	5.6	No	No	0	0	9
38	R:R:D113	R:R:Y167	53.6165	11.49	No	Yes	3	9	5
39	L:L:H32	R:R:Y167	31.5959	11.98	Yes	Yes	0	0	5
40	L:L:H32	L:L:I36	26.0953	6.63	Yes	No	0	0	0
41	L:L:I36	R:R:W164	24.9727	2.35	No	Yes	0	0	5
42	L:L:E35	R:R:W164	14.5965	16.36	No	Yes	0	0	5
43	L:L:E35	R:R:N161	13.4132	10.52	No	No	0	0	7
44	R:R:R146	R:R:Y167	27.4029	5.14	Yes	Yes	3	8	5
45	R:R:L116	R:R:R146	25.2093	4.86	Yes	Yes	3	5	8
46	R:R:L116	R:R:P110	14.5237	6.57	Yes	No	3	5	6
47	R:R:L109	R:R:P110	13.48	3.28	Yes	No	0	5	6
48	R:R:N161	R:R:P158	11.0285	13.03	No	No	0	7	4
49	R:R:Q438	R:R:W437	18.6226	3.29	No	Yes	0	4	5
50	R:R:H442	R:R:Q438	15.98	2.47	No	No	0	5	4
51	R:R:H442	R:R:R186	13.3313	6.77	No	No	0	5	5
52	R:R:Y191	R:R:Y195	20.9345	3.97	Yes	Yes	0	7	7
53	R:R:H420	R:R:N448	13.7379	7.65	Yes	Yes	1	8	6
54	R:R:H420	R:R:Y443	17.5182	6.53	Yes	Yes	1	8	4
55	R:R:E444	R:R:Y443	16.2318	5.61	Yes	Yes	1	7	4
56	R:R:S449	R:R:Y195	15.9223	5.09	No	Yes	1	9	7
57	R:R:F450	R:R:S449	12.5152	5.28	No	No	1	7	9
58	R:R:F288	R:R:L289	61.6141	6.09	No	Yes	0	7	7
59	R:R:F288	R:R:I237	61.3987	3.77	No	No	0	7	7
60	R:R:F450	R:R:F454	11.5746	6.43	No	No	0	7	6
61	R:R:F453	R:R:F454	10.7403	5.36	Yes	No	0	6	6
62	R:R:N295	R:R:R233	83.5255	10.85	No	Yes	0	8	8
63	R:R:F230	R:R:N295	87.6547	20.54	Yes	No	0	8	8
64	R:R:F230	R:R:G452	21.0133	3.01	Yes	No	0	8	9
65	R:R:G452	R:R:L202	19.6784	5.13	No	Yes	0	9	9
66	R:R:F453	R:R:I457	10.4096	8.79	Yes	No	0	6	6
67	R:R:F230	R:R:L226	100	6.09	Yes	No	9	8	9
68	R:R:E302	R:R:L226	99.2385	6.63	Yes	No	0	9	9
69	R:R:E302	R:R:H223	24.3265	8.62	Yes	No	0	9	9
70	R:R:H223	R:R:R219	22.949	6.77	No	No	0	9	9
71	R:R:E465	R:R:R219	15.9405	6.98	No	No	0	9	9
72	R:R:E465	R:R:L215	14.5206	2.65	No	No	0	9	9
73	R:R:F212	R:R:L215	10.2245	7.31	Yes	No	0	7	9
74	R:R:E302	R:R:I222	24.3416	6.83	Yes	No	0	9	9
75	R:R:I222	R:R:Y305	17.2178	8.46	No	Yes	5	9	8
76	R:R:N295	R:R:S229	21.0225	5.96	No	No	0	8	9
77	R:R:S229	R:R:T294	19.9818	3.2	No	Yes	0	9	8
78	R:R:F230	R:R:Q451	26.2166	5.86	Yes	No	0	8	9
79	R:R:H420	R:R:Q451	26.2166	3.71	Yes	No	0	8	9
80	R:R:T294	R:R:Y290	13.0188	8.74	Yes	Yes	2	8	9
81	R:R:L289	R:R:W339	38.6468	6.83	Yes	Yes	1	7	8
82	R:R:V340	R:R:W339	10.9011	3.68	No	Yes	1	5	8
83	R:R:T286	R:R:V340	10.3853	3.17	Yes	No	1	7	5
84	R:R:T286	R:R:V336	21.4745	3.17	Yes	No	0	7	7
85	R:R:V336	R:R:Y290	20.7979	5.05	No	Yes	0	7	9
86	R:R:W339	R:R:W352	18.7894	10.31	Yes	Yes	1	8	8
87	R:R:T286	R:R:W352	14.2263	4.85	Yes	Yes	1	7	8
88	R:R:E302	R:R:L416	60.6007	9.28	Yes	No	0	9	9
89	R:R:L416	R:R:Y459	59.3811	15.24	No	No	0	9	8
90	R:R:I458	R:R:Y459	56.9417	12.09	No	No	0	8	8
91	R:R:I458	R:R:P415	53.2373	5.08	No	No	0	8	9
92	R:R:M414	R:R:P415	51.9933	3.35	No	No	0	8	9
93	R:R:M414	R:R:V419	50.7373	7.61	No	No	0	8	7
94	R:R:F378	R:R:V419	49.4751	6.55	Yes	No	0	9	7
95	R:R:F378	R:R:F417	22.7154	16.08	Yes	Yes	10	9	9
96	R:R:F417	R:R:N374	20.1729	12.08	Yes	No	0	9	9
97	R:R:L300	R:R:N374	17.3635	5.49	Yes	No	0	8	9
98	R:R:L300	R:R:L304	13.1038	6.92	Yes	No	0	8	5
99	R:R:L304	R:R:L377	11.6717	4.15	No	No	0	5	7
100	R:R:F324	R:R:Y305	13.0765	7.22	No	Yes	0	7	8
101	R:R:H307	R:R:L377	10.2336	6.43	No	No	0	8	7
102	R:R:F324	R:R:Y320	11.6475	3.09	No	No	0	7	4
103	R:R:I362	R:R:W339	10.5006	4.7	No	Yes	0	8	8
104	R:R:F378	R:R:V382	20.1729	7.87	Yes	No	0	9	7
105	R:R:T410	R:R:V382	18.7712	4.76	No	No	0	9	7
106	R:R:L406	R:R:T410	17.3635	2.95	No	No	0	8	9
107	R:R:L389	R:R:L406	14.5297	4.15	No	No	0	8	8
108	R:R:L389	R:R:Q402	11.6717	3.99	No	No	0	8	6
109	L:L:S14	R:R:R181	11.4472	2.64	No	No	0	0	3
110	L:L:S3	R:R:E444	39.4994	8.62	No	Yes	1	0	7
111	R:R:M445	R:R:Y191	15.1365	4.79	No	Yes	0	6	7
112	R:R:I237	R:R:Y195	61.4806	8.46	No	Yes	0	7	7
113	R:R:F184	R:R:L187	24.9181	4.87	No	No	0	6	5
114	L:L:D10	R:R:W437	16.8356	5.58	No	Yes	1	0	5
115	L:L:K11	R:R:F184	23.0583	11.17	No	No	0	0	6
116	R:R:D353	R:R:Y245	19.0018	9.2	Yes	Yes	4	5	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:A1	R:R:Q364	4.55	0	No	Yes	0	7	0	1
L:L:A1	R:R:L368	3.15	0	No	No	0	4	0	1
L:L:V2	R:R:L292	2.98	0	No	Yes	0	6	0	1
L:L:V2	R:R:Q364	10.03	0	No	Yes	0	7	0	1
L:L:V2	R:R:I367	4.61	0	No	No	0	7	0	1
L:L:S3	R:R:M441	6.13	1	No	Yes	0	6	0	1
L:L:S3	R:R:E444	8.62	1	No	Yes	0	7	0	1
L:L:S3	R:R:M445	3.07	1	No	No	0	6	0	1
L:L:E4	R:R:Y195	5.61	1	No	Yes	0	7	0	1
L:L:E4	R:R:R233	10.47	1	No	Yes	0	8	0	1
L:L:E4	R:R:L292	5.3	1	No	Yes	0	6	0	1
L:L:H5	R:R:L289	5.14	1	Yes	Yes	0	7	0	1
L:L:H5	R:R:K360	5.24	1	Yes	Yes	0	7	0	1
L:L:H5	R:R:Q364	8.65	1	Yes	Yes	0	7	0	1
L:L:Q6	R:R:Y429	25.93	1	No	Yes	0	6	0	1
L:L:Q6	R:R:W437	3.29	1	No	Yes	0	5	0	1
L:L:L7	R:R:L187	4.15	0	No	No	0	5	0	1
L:L:L7	R:R:M441	4.24	0	No	Yes	0	6	0	1
L:L:L8	R:R:K240	5.64	4	Yes	No	0	7	0	1
L:L:L8	R:R:Y245	4.69	4	Yes	Yes	0	4	0	1
L:L:L8	R:R:V285	2.98	4	Yes	No	0	6	0	1
L:L:L8	R:R:D353	9.5	4	Yes	Yes	0	5	0	1
L:L:H9	R:R:S355	9.76	1	Yes	No	0	7	0	1
L:L:H9	R:R:K360	6.55	1	Yes	Yes	0	7	0	1
L:L:H9	R:R:Y429	3.27	1	Yes	Yes	0	6	0	1
L:L:D10	R:R:V432	4.38	1	No	No	0	5	0	1
L:L:D10	R:R:W437	5.58	1	No	Yes	0	5	0	1
L:L:K11	R:R:F184	11.17	0	No	No	0	6	0	1
L:L:K11	R:R:Y245	16.72	0	No	Yes	0	4	0	1
L:L:G12	R:R:D353	3.35	0	No	Yes	0	5	0	1
L:L:K13	R:R:V31	4.55	0	No	No	0	6	0	1
L:L:S14	R:R:E180	8.62	0	No	Yes	0	3	0	1
L:L:Q16	R:R:T33	11.34	0	No	No	0	7	0	1
L:L:R19	R:R:K34	7.43	6	No	No	0	4	0	1
L:L:R19	R:R:E35	6.98	6	No	No	0	5	0	1
L:L:R20	R:R:Y136	9.26	0	Yes	No	0	4	0	1
L:L:R20	R:R:D137	4.76	0	Yes	No	0	5	0	1
L:L:R21	R:R:D137	14.29	0	No	No	0	5	0	1
L:L:R21	R:R:F173	5.34	0	No	No	0	3	0	1
L:L:F23	R:R:K34	4.96	0	No	No	0	4	0	1
L:L:L27	R:R:H114	5.14	0	No	Yes	0	4	0	1
L:L:I31	R:R:D113	5.6	0	No	No	0	9	0	1
L:L:H32	R:R:Y167	11.98	0	Yes	Yes	0	5	0	1
L:L:H32	R:R:S168	5.58	0	Yes	No	0	6	0	1
L:L:E35	R:R:N161	10.52	0	No	No	0	7	0	1
L:L:E35	R:R:W164	16.36	0	No	Yes	0	5	0	1
R:R:M32	R:R:Y136	4.79	0	No	No	6	4	2	1
R:R:E35	R:R:T33	8.47	6	No	No	5	7	1	1
R:R:E35	R:R:K34	8.1	6	No	No	5	4	1	1
R:R:H114	R:R:L41	18	0	Yes	No	4	8	1	2
R:R:L41	R:R:Y134	3.52	0	No	Yes	8	5	2	2
R:R:H114	R:R:Q45	3.71	0	Yes	No	4	7	1	2
R:R:H114	R:R:W112	5.29	0	Yes	No	4	7	1	2
R:R:D113	R:R:I115	5.6	3	No	No	9	5	1	2
R:R:D113	R:R:Y167	11.49	3	No	Yes	9	5	1	1
R:R:I115	R:R:Y167	8.46	3	No	Yes	5	5	2	1
R:R:I135	R:R:Y134	6.04	0	Yes	Yes	7	5	1	2
R:R:F138	R:R:I135	11.3	8	Yes	Yes	4	7	2	1
R:R:A165	R:R:R146	4.15	3	No	Yes	7	8	2	2
R:R:R146	R:R:Y167	5.14	3	Yes	Yes	8	5	2	1
R:R:R147	R:R:W164	8	0	No	Yes	3	5	2	1
R:R:N161	R:R:P158	13.03	0	No	No	7	4	1	2
R:R:N166	R:R:W164	4.52	0	No	Yes	7	5	2	1
R:R:A165	R:R:Y167	6.67	3	No	Yes	7	5	2	1
R:R:E177	R:R:E180	5.07	0	No	Yes	1	3	2	1
R:R:E180	R:R:F184	5.83	0	Yes	No	3	6	1	1
R:R:E180	R:R:V432	8.56	0	Yes	No	3	5	1	1
R:R:F184	R:R:L187	4.87	0	No	No	6	5	1	1
R:R:Y191	R:R:Y195	3.97	0	Yes	Yes	7	7	2	1
R:R:M445	R:R:Y191	4.79	1	No	Yes	6	7	1	2
R:R:R233	R:R:Y195	13.38	1	Yes	Yes	8	7	1	1
R:R:A234	R:R:Y195	4	0	No	Yes	8	7	2	1
R:R:I237	R:R:Y195	8.46	0	No	Yes	7	7	2	1
R:R:S449	R:R:Y195	5.09	1	No	Yes	9	7	2	1
R:R:L292	R:R:R233	6.07	1	Yes	Yes	6	8	1	1
R:R:N295	R:R:R233	10.85	0	No	Yes	8	8	2	1
R:R:R233	R:R:Y296	5.14	1	Yes	Yes	8	7	1	2
R:R:N448	R:R:R233	3.62	1	Yes	Yes	6	8	2	1
R:R:F288	R:R:I237	3.77	0	No	No	7	7	2	2
R:R:L244	R:R:Y245	3.52	4	Yes	Yes	5	4	2	1
R:R:D353	R:R:L244	8.14	4	Yes	Yes	5	5	1	2
R:R:D353	R:R:Y245	9.2	4	Yes	Yes	5	4	1	1
R:R:L289	R:R:V285	2.98	1	Yes	No	7	6	1	1
R:R:F288	R:R:L289	6.09	0	No	Yes	7	7	2	1
R:R:L289	R:R:W339	6.83	1	Yes	Yes	7	8	1	2
R:R:I363	R:R:L289	4.28	1	No	Yes	7	7	2	1
R:R:L292	R:R:Y296	4.69	1	Yes	Yes	6	7	1	2
R:R:I367	R:R:Y296	14.51	0	No	Yes	7	7	1	2
R:R:I363	R:R:W339	3.52	1	No	Yes	7	8	2	2
R:R:K360	R:R:W361	5.8	1	Yes	Yes	7	8	1	2
R:R:K360	R:R:Q364	4.07	1	Yes	Yes	7	7	1	1
R:R:K360	R:R:Y429	14.33	1	Yes	Yes	7	6	1	1
R:R:Q364	R:R:W361	3.29	1	Yes	Yes	7	8	1	2
R:R:Q364	R:R:Y429	5.64	1	Yes	Yes	7	6	1	1
R:R:L368	R:R:M425	5.65	0	No	No	4	6	1	2
R:R:F424	R:R:Y443	8.25	1	Yes	Yes	7	4	2	2
R:R:E444	R:R:F424	3.5	1	Yes	Yes	7	7	1	2
R:R:T430	R:R:W437	3.64	0	No	Yes	5	5	2	1
R:R:Q438	R:R:W437	3.29	0	No	Yes	4	5	2	1
R:R:M441	R:R:W437	16.29	1	Yes	Yes	6	5	1	1
R:R:M441	R:R:M445	4.33	1	Yes	No	6	6	1	1
R:R:E444	R:R:Y443	5.61	1	Yes	Yes	7	4	1	2
R:R:E444	R:R:N448	10.52	1	Yes	Yes	7	6	1	2
R:R:D353	R:R:L354	2.71	4	Yes	No	5	5	1	1
R:R:A144	R:R:Y167	2.67	0	No	Yes	7	5	2	1
L:L:Q16	R:R:L354	2.66	0	No	No	0	5	0	1
L:L:S14	R:R:R181	2.64	0	No	No	0	3	0	1
R:R:S198	R:R:Y195	2.54	0	No	Yes	9	7	2	1
L:L:F23	R:R:I38	2.51	0	No	No	0	7	0	1
L:L:L18	R:R:R181	2.43	0	No	No	0	3	0	1
L:L:I15	R:R:Y245	2.42	0	No	Yes	0	4	0	1
R:R:D185	R:R:R181	2.38	0	No	No	2	3	2	1
L:L:I36	R:R:W164	2.35	0	No	Yes	0	5	0	1
L:L:R20	R:R:Q37	2.34	0	Yes	No	0	7	0	1
L:L:A34	R:R:N161	1.56	0	No	No	0	7	0	1
L:L:D17	R:R:V31	1.46	0	No	No	0	6	0	1
L:L:L24	R:R:I135	1.43	0	No	Yes	0	7	0	1
R:R:I135	R:R:Q37	1.37	0	Yes	No	7	7	1	1
R:R:H42	R:R:I38	1.33	0	No	No	4	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8HAF_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.98
Number of Linked Nodes	374
Number of Links	421
Number of Hubs	59
Number of Links mediated by Hubs	214
Number of Communities	12
Number of Nodes involved in Communities	85
Number of Links involved in Communities	113

Path Summary
Number Of Nodes in MetaPath	117
Number Of Links MetaPath	116
Number of Shortest Paths	90769
Length Of Smallest Path	3
Average Path Length	17.7397
Length of Longest Path	49
Minimum Path Strength	1.365
Average Path Strength	6.74475
Maximum Path Strength	20.13
Minimum Path Correlation	0.7
Average Path Correlation	0.965562
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.77778
Average % Of Corr. Nodes	65.123
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	39.7962
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q03431
Sequence	>8HAF_nogp_Chain_R V M T K E E Q I F L L H R A Q A Q C E K R L K E V G R P C L P E W D H I L C W P L G A P G E V V A V P C P D Y I Y D F N H K G H A Y R R C D R N G S W E L V P G H N R T W A N Y S E C V K F L T N E T R E R E V F D R L A M I Y T V G Y S V S L A S L T V A V L I L A Y F R R L H C T R N Y I H M H L F L S F M L R A V S I F V K D A V L Y S G A G Y A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M A F F S E K K Y L W G F T V F G W G L P A V F V A V W V S V R A T L A N T G C W D L S S G N K K W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L R E T N T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M A T P Y T E V S G T L W Q V Q M H Y E M L F N S F Q G F F V A I I Y C F C N G E V Q A E I K K S W S R W T L A L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8GW8	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371	Gs/β1/γ2	2.9	2023-06-14	doi.org/10.1038/s41586-023-06169-3
	8GW8 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371		2.9	2023-06-14	doi.org/10.1038/s41586-023-06169-3
	8JR9	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371	chim(NtGi1-Gs)/β1/γ2	2.57	2023-08-02	doi.org/10.1038/s41586-023-06467-w
	8JR9 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371		2.57	2023-08-02	doi.org/10.1038/s41586-023-06467-w
	7VVJ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVJ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVK	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.3	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVK (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.3	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVL	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVL (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVM	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVM (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVN	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVN (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	4.1	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		4.1	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	8FLQ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.55	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLQ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.55	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLR	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	2.94	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLR (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		2.94	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLS	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	3.09	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLS (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		3.09	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLT	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-	Gs/β1/γ2	3.03	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLT (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-		3.03	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLU	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-	Gs/β1/γ2	2.76	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLU (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-		2.76	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8HA0	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	2.62	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HA0 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.62	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	chim(NtGi1-Gs)/β1/γ2	3.25	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.25	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	3.76	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.76	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	6FJ3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	-	2.5	2018-11-21	doi.org/10.1038/s41594-018-0151-4
	6NBF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	3	2019-04-17	doi.org/10.1126/science.aav7942
	6NBF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		3	2019-04-17	doi.org/10.1126/science.aav7942
	6NBH	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	3.5	2019-04-17	doi.org/10.1126/science.aav7942
	6NBH (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		3.5	2019-04-17	doi.org/10.1126/science.aav7942
	6NBI	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	4	2019-04-17	doi.org/10.1126/science.aav7942
	6NBI (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		4	2019-04-17	doi.org/10.1126/science.aav7942
	9B5Y	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-	chim(NtGi1-Gq)/β1/γ2	3.49	2025-03-19	doi.org/10.1073/pnas.2426178122
	9B5Y (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-		3.49	2025-03-19	doi.org/10.1073/pnas.2426178122
	7Y35	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	2.9	2023-07-05	To be published
	7Y35 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		2.9	2023-07-05	To be published
	7Y36	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Teriparatide	-	Gs/β1/γ2	2.8	2023-07-05	To be published
	7Y36 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Teriparatide	-		2.8	2023-07-05	To be published
	9JR2	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	To be published
	9JR2 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	To be published
	9JR3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	To be published
	9JR3 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8HAF_nogp.zip

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