psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:V2	5.71	No	No	2	0	0
2	L:L:?1	R:R:Q364	5.1	No	Yes	2	0	7
3	L:L:?1	R:R:L368	6.63	No	No	0	0	4
4	L:L:I5	L:L:V2	9.22	No	No	2	0	0
5	L:L:V2	R:R:Q364	8.6	No	Yes	2	0	7
6	L:L:?3	L:L:E4	5.08	No	Yes	1	0	0
7	L:L:?3	R:R:E444	16.5	No	No	1	0	7
8	L:L:?3	R:R:M445	5.42	No	Yes	1	0	6
9	L:L:E4	R:R:R233	6.98	Yes	Yes	1	0	8
10	L:L:E4	R:R:L292	5.3	Yes	No	1	0	6
11	L:L:E4	R:R:M445	8.12	Yes	Yes	1	0	6
12	L:L:E4	R:R:N448	6.57	Yes	Yes	1	0	6
13	L:L:I5	R:R:Q364	13.72	No	Yes	2	0	7
14	L:L:Q10	L:L:Q6	7.68	No	Yes	0	0	0
15	L:L:Q6	R:R:Y429	19.16	Yes	Yes	0	0	6
16	L:L:Q6	R:R:Q440	5.12	Yes	Yes	0	0	6
17	L:L:Q6	R:R:M441	6.8	Yes	No	0	0	6
18	L:L:M8	R:R:F288	4.98	No	No	0	0	7
19	L:L:M8	R:R:D353	6.93	No	Yes	0	0	5
20	L:L:H9	R:R:S355	8.37	No	No	2	0	7
21	L:L:H9	R:R:K360	7.86	No	Yes	2	0	7
22	L:L:H9	R:R:Y429	13.07	No	Yes	2	0	6
23	L:L:?11	R:R:F184	6.64	No	No	0	0	6
24	L:L:?11	R:R:Y245	28.32	No	No	0	0	4
25	L:L:A12	R:R:D353	6.18	No	Yes	0	0	5
26	L:L:W14	R:R:E180	13.08	No	No	0	0	3
27	L:L:W14	R:R:R181	7	No	No	0	0	3
28	R:R:E177	R:R:E180	15.22	No	No	0	1	3
29	R:R:D185	R:R:R181	20.25	No	No	0	2	3
30	R:R:Q438	R:R:V183	10.03	No	No	0	4	4
31	R:R:F184	R:R:W437	5.01	No	Yes	0	6	5
32	R:R:H442	R:R:R186	5.64	No	No	0	5	5
33	R:R:H442	R:R:L187	10.29	No	No	0	5	5
34	R:R:G188	R:R:Y191	5.79	No	Yes	0	5	7
35	R:R:Y191	R:R:Y195	5.96	Yes	Yes	0	7	7
36	R:R:D241	R:R:Y191	10.34	No	Yes	0	8	7
37	R:R:M445	R:R:Y191	8.38	Yes	Yes	0	6	7
38	R:R:F238	R:R:T192	5.19	No	No	0	7	7
39	R:R:F450	R:R:G194	9.03	No	No	0	7	9
40	R:R:R233	R:R:Y195	11.32	Yes	Yes	0	8	7
41	R:R:A234	R:R:Y195	5.34	No	Yes	0	8	7
42	R:R:I237	R:R:Y195	8.46	No	Yes	0	7	7
43	R:R:F453	R:R:V197	5.24	Yes	No	0	6	5
44	R:R:F453	R:R:S201	6.61	Yes	No	0	6	8
45	R:R:F227	R:R:L202	4.87	No	No	0	9	9
46	R:R:F230	R:R:L202	4.87	Yes	No	0	8	9
47	R:R:M231	R:R:T203	7.53	No	No	0	8	3
48	R:R:L209	R:R:M224	5.65	No	No	0	7	5
49	R:R:F227	R:R:L209	4.87	No	No	0	9	7
50	R:R:F212	R:R:Y211	9.28	Yes	No	0	7	2
51	R:R:F212	R:R:L215	4.87	Yes	No	0	7	9
52	R:R:E469	R:R:F212	11.66	No	Yes	0	9	7
53	R:R:F212	R:R:I470	5.02	Yes	No	0	7	5
54	R:R:E469	R:R:R214	10.47	No	No	0	9	7
55	R:R:E465	R:R:L215	5.3	No	No	0	9	9
56	R:R:H216	R:R:Y221	8.71	No	No	0	8	7
57	R:R:T218	R:R:Y305	8.74	No	Yes	0	7	8
58	R:R:E317	R:R:T218	8.47	No	No	0	6	7
59	R:R:N220	R:R:R219	6.03	No	No	0	9	9
60	R:R:H223	R:R:R219	6.77	No	No	0	9	9
61	R:R:E302	R:R:I222	5.47	Yes	No	0	9	9
62	R:R:I222	R:R:Y305	8.46	No	Yes	0	9	8
63	R:R:E302	R:R:H223	8.62	Yes	No	0	9	9
64	R:R:H225	R:R:W298	17.98	No	Yes	5	8	9
65	R:R:H225	R:R:T325	8.21	No	No	0	8	5
66	R:R:H225	R:R:W329	6.35	No	No	5	8	9
67	R:R:F230	R:R:L226	7.31	Yes	No	0	8	9
68	R:R:E302	R:R:L226	17.23	Yes	No	0	9	9
69	R:R:L228	R:R:L232	5.54	No	No	0	4	8
70	R:R:N295	R:R:S229	7.45	Yes	No	0	8	9
71	R:R:S229	R:R:W298	7.41	No	Yes	0	9	9
72	R:R:F230	R:R:N295	16.92	Yes	Yes	0	8	8
73	R:R:F230	R:R:Q451	7.03	Yes	Yes	0	8	9
74	R:R:F230	R:R:G452	7.53	Yes	No	0	8	9
75	R:R:F230	R:R:V455	5.24	Yes	No	0	8	9
76	R:R:F291	R:R:L232	14.61	Yes	No	0	5	8
77	R:R:L292	R:R:R233	7.29	No	Yes	1	6	8
78	R:R:N295	R:R:R233	10.85	Yes	Yes	0	8	8
79	R:R:R233	R:R:Y296	7.2	Yes	Yes	1	8	7
80	R:R:N448	R:R:R233	6.03	Yes	Yes	1	6	8
81	R:R:F291	R:R:S236	9.25	Yes	No	0	5	7
82	R:R:F288	R:R:K240	21.09	No	No	0	7	7
83	R:R:A284	R:R:V243	5.09	No	No	0	6	5
84	R:R:L244	R:R:Y245	17.58	Yes	No	3	5	4
85	R:R:D353	R:R:L244	12.21	Yes	Yes	3	5	5
86	R:R:D353	R:R:Y245	8.05	Yes	No	3	5	4
87	R:R:C281	R:R:C351	7.28	No	No	3	9	9
88	R:R:N348	R:R:R282	4.82	No	No	0	7	8
89	R:R:R282	R:R:W352	17.99	No	Yes	0	8	8
90	R:R:F287	R:R:F291	7.5	No	Yes	0	3	5
91	R:R:F291	R:R:Y290	8.25	Yes	No	0	5	9
92	R:R:T294	R:R:Y290	8.74	No	No	0	8	9
93	R:R:A333	R:R:Y290	5.34	No	No	0	5	9
94	R:R:T294	R:R:W329	6.06	No	No	0	8	9
95	R:R:P332	R:R:T294	5.25	No	No	0	9	8
96	R:R:I299	R:R:N295	5.66	No	Yes	0	9	8
97	R:R:I367	R:R:Y296	8.46	No	Yes	0	7	7
98	R:R:I371	R:R:Y296	4.84	No	Yes	1	7	7
99	R:R:Y296	R:R:Y421	19.86	Yes	Yes	1	7	8
100	R:R:F327	R:R:Y297	7.22	No	Yes	0	5	6
101	R:R:P332	R:R:Y297	11.13	No	Yes	0	9	6
102	R:R:F335	R:R:Y297	6.19	No	Yes	0	5	6
103	R:R:S370	R:R:Y297	6.36	No	Yes	0	7	6
104	R:R:V301	R:R:W298	8.58	No	Yes	0	8	9
105	R:R:W298	R:R:W329	25.3	Yes	No	5	9	9
106	R:R:I299	R:R:Q451	5.49	No	Yes	0	9	9
107	R:R:E302	R:R:L416	11.93	Yes	No	0	9	9
108	R:R:F417	R:R:G303	6.02	Yes	No	0	9	9
109	R:R:L309	R:R:Y305	16.41	No	Yes	0	8	8
110	R:R:F315	R:R:Y305	5.16	No	Yes	0	6	8
111	R:R:I381	R:R:L306	5.71	No	No	0	9	9
112	R:R:F417	R:R:L306	4.87	Yes	No	0	9	9
113	R:R:F311	R:R:H307	16.97	Yes	No	7	6	8
114	R:R:H307	R:R:L377	5.14	No	No	0	8	7
115	R:R:H307	R:R:N380	6.38	No	No	7	8	8
116	R:R:F315	R:R:S308	7.93	No	No	0	6	7
117	R:R:F311	R:R:I310	5.02	Yes	No	0	6	8
118	R:R:F311	R:R:N380	12.08	Yes	No	7	6	8
119	R:R:F311	R:R:V384	7.87	Yes	No	0	6	8
120	R:R:F315	R:R:Y320	8.25	No	Yes	0	6	4
121	R:R:K319	R:R:S316	9.18	No	No	0	6	7
122	R:R:K318	R:R:K319	5.75	No	No	0	5	6
123	R:R:K319	R:R:Y320	8.36	No	Yes	0	6	4
124	R:R:V326	R:R:W322	14.71	No	No	0	4	3
125	R:R:F327	R:R:L331	7.31	No	No	0	5	4
126	R:R:F335	R:R:I363	7.54	No	No	0	5	7
127	R:R:F335	R:R:P366	15.89	No	No	0	5	9
128	R:R:R343	R:R:W339	9	Yes	Yes	4	8	8
129	R:R:W339	R:R:W352	5.62	Yes	Yes	4	8	8
130	R:R:I363	R:R:W339	11.74	No	Yes	0	7	8
131	R:R:R343	R:R:W352	16.99	Yes	Yes	4	8	8
132	R:R:R343	R:R:S356	11.86	Yes	No	0	8	4
133	R:R:K359	R:R:L346	7.05	No	No	0	3	3
134	R:R:K360	R:R:S355	10.71	Yes	No	2	7	7
135	R:R:K360	R:R:W361	6.96	Yes	Yes	0	7	8
136	R:R:K360	R:R:Y429	16.72	Yes	Yes	2	7	6
137	R:R:Q364	R:R:W361	7.67	Yes	Yes	0	7	8
138	R:R:V365	R:R:W361	6.13	No	Yes	0	5	8
139	R:R:Q364	R:R:Y429	10.15	Yes	Yes	2	7	6
140	R:R:I371	R:R:Y421	8.46	No	Yes	1	7	8
141	R:R:I371	R:R:M425	7.29	No	No	0	7	6
142	R:R:L373	R:R:L377	6.92	No	No	0	7	7
143	R:R:F417	R:R:N374	8.46	Yes	No	0	9	9
144	R:R:F375	R:R:I422	16.33	No	No	0	7	5
145	R:R:F378	R:R:V382	7.87	Yes	No	0	9	7
146	R:R:F378	R:R:L413	6.09	Yes	No	6	9	9
147	R:R:F378	R:R:F417	8.57	Yes	Yes	6	9	9
148	R:R:F378	R:R:V419	11.8	Yes	No	0	9	7
149	R:R:N380	R:R:R383	8.44	No	No	0	8	8
150	R:R:T410	R:R:V382	7.93	No	No	0	9	7
151	R:R:R390	R:R:T387	5.17	No	No	0	6	7
152	R:R:E391	R:R:T387	5.64	No	No	0	7	7
153	R:R:L389	R:R:Q402	6.65	No	No	0	8	6
154	R:R:F417	R:R:L413	12.18	Yes	No	6	9	9
155	R:R:I458	R:R:P415	5.08	No	No	0	8	9
156	R:R:F417	R:R:L416	4.87	Yes	No	0	9	9
157	R:R:L416	R:R:Y459	23.45	No	No	0	9	8
158	R:R:H420	R:R:Y421	13.07	Yes	Yes	1	8	8
159	R:R:F447	R:R:H420	12.44	No	Yes	0	5	8
160	R:R:H420	R:R:N448	5.1	Yes	Yes	1	8	6
161	R:R:H420	R:R:Q451	9.89	Yes	Yes	0	8	9
162	R:R:N448	R:R:Y421	12.79	Yes	Yes	1	6	8
163	R:R:F424	R:R:V423	6.55	Yes	No	0	7	6
164	R:R:F424	R:R:Q440	9.37	Yes	Yes	1	7	6
165	R:R:F424	R:R:Y443	7.22	Yes	No	0	7	4
166	R:R:E444	R:R:F424	7	No	Yes	1	7	7
167	R:R:Q440	R:R:T427	8.5	Yes	No	0	6	5
168	R:R:T430	R:R:W437	4.85	No	Yes	0	5	5
169	R:R:V432	R:R:W437	12.26	No	Yes	0	5	5
170	R:R:Q438	R:R:W437	7.67	No	Yes	0	4	5
171	R:R:M441	R:R:W437	22.1	No	Yes	0	6	5
172	R:R:H442	R:R:Q438	7.42	No	No	0	5	4
173	R:R:E444	R:R:Q440	5.1	No	Yes	1	7	6
174	R:R:F447	R:R:Y443	15.47	No	No	0	5	4
175	R:R:F450	R:R:L446	4.87	No	No	0	7	5
176	R:R:F450	R:R:S449	6.61	No	No	0	7	9
177	R:R:F453	R:R:I457	11.3	Yes	No	0	6	6
178	R:R:F461	R:R:I457	5.02	No	No	0	8	6
179	R:R:I458	R:R:Y459	7.25	No	No	0	8	8
180	R:R:C460	R:R:F461	5.59	Yes	No	0	9	8
181	R:R:N463	R:R:V466	8.87	No	No	0	9	9
182	R:R:E469	R:R:K472	6.75	No	No	0	9	7
183	R:R:K472	R:R:R476	18.56	No	No	0	7	7
184	R:R:T478	R:R:W474	9.7	No	No	0	4	5
185	R:R:T286	R:R:V340	4.76	No	No	0	7	5
186	R:R:I362	R:R:W339	4.7	No	Yes	0	8	8
187	R:R:I363	R:R:V336	4.61	No	No	0	7	7
188	R:R:I362	R:R:V342	4.61	No	No	0	8	5
189	R:R:K359	R:R:S356	4.59	No	No	0	3	4
190	R:R:K405	R:R:S409	4.59	No	No	0	8	9
191	R:R:L289	R:R:W339	4.56	No	Yes	0	7	8
192	R:R:M414	R:R:V419	4.56	No	No	0	8	7
193	R:R:K408	R:R:V412	4.55	No	No	0	8	8
194	R:R:F327	R:R:G328	4.52	No	No	0	5	9
195	R:R:N358	R:R:W361	4.52	No	Yes	0	4	8
196	R:R:L300	R:R:S370	4.5	No	No	0	8	7
197	R:R:I208	R:R:I470	4.42	No	No	0	8	5
198	R:R:L346	R:R:T345	4.42	No	No	0	3	3
199	R:R:L436	R:R:T430	4.42	No	No	0	4	5
200	R:R:F453	R:R:F454	4.29	Yes	No	0	6	6
201	L:L:L7	R:R:M445	4.24	No	Yes	0	0	6
202	R:R:L199	R:R:M231	4.24	No	No	0	7	8
203	R:R:A313	R:R:F314	4.16	No	No	0	7	7
204	R:R:L300	R:R:L304	4.15	No	No	0	8	5
205	R:R:L300	R:R:L373	4.15	No	No	0	8	7
206	R:R:A347	R:R:R343	4.15	No	Yes	0	7	8
207	R:R:L407	R:R:L411	4.15	No	No	0	8	8
208	L:L:W14	R:R:F184	4.01	No	No	0	0	6
209	R:R:F238	R:R:S196	3.96	No	No	0	7	7
210	R:R:F212	R:R:S473	3.96	Yes	No	0	7	4
211	R:R:E465	R:R:N463	3.94	No	No	0	9	9
212	R:R:F461	R:R:V204	3.93	No	No	0	8	5
213	R:R:S449	R:R:Y195	3.82	No	Yes	0	9	7
214	R:R:F375	R:R:I379	3.77	No	No	0	7	5
215	R:R:F378	R:R:I379	3.77	Yes	No	0	9	5
216	R:R:G452	R:R:S198	3.71	No	No	0	9	9
217	R:R:V340	R:R:W339	3.68	No	Yes	4	5	8
218	R:R:V340	R:R:W352	3.68	No	Yes	4	5	8
219	R:R:G350	R:R:T349	3.64	No	No	0	5	5
220	R:R:A205	R:R:C460	3.61	No	Yes	0	9	9
221	R:R:M312	R:R:Y320	3.59	No	Yes	0	5	4
222	R:R:P428	R:R:T427	3.5	No	No	0	7	5
223	R:R:C281	R:R:V243	3.42	No	No	0	9	5
224	R:R:G464	R:R:N463	3.39	No	No	0	7	9
225	R:R:Q402	R:R:Y403	3.38	No	No	0	6	7
226	R:R:G418	R:R:Q451	3.29	No	Yes	0	9	9
227	R:R:C460	R:R:I208	3.27	Yes	No	0	9	8
228	R:R:A293	R:R:I367	3.25	No	No	0	6	7
229	R:R:S475	R:R:T478	3.2	No	No	0	4	4
230	R:R:C460	R:R:L209	3.17	Yes	No	0	9	7
231	R:R:C281	R:R:L244	3.17	No	Yes	3	9	5
232	R:R:C351	R:R:L244	3.17	No	Yes	3	9	5
233	L:L:A12	R:R:L354	3.15	No	No	0	0	5
234	R:R:A456	R:R:L202	3.15	No	No	0	8	9
235	R:R:C217	R:R:N220	3.15	No	No	0	8	9
236	R:R:A344	R:R:N348	3.13	No	No	0	4	7
237	R:R:F238	R:R:Y195	3.09	No	Yes	0	7	7
238	R:R:F324	R:R:Y320	3.09	No	Yes	0	7	4
239	L:L:M8	R:R:V285	3.04	No	No	0	0	6
240	R:R:M425	R:R:V372	3.04	No	No	0	6	4
241	R:R:G277	R:R:R282	3	No	No	0	4	8
242	R:R:L385	R:R:S409	3	No	No	0	8	9
243	R:R:L199	R:R:V235	2.98	No	No	0	7	4
244	R:R:I190	R:R:M445	2.92	No	Yes	0	6	6
245	R:R:I222	R:R:L321	2.85	No	No	0	9	6
246	R:R:K405	R:R:L389	2.82	No	No	0	8	8
247	R:R:F227	R:R:V206	2.62	No	No	0	9	5
248	R:R:L407	R:R:R404	2.43	No	No	0	8	6
249	R:R:M224	R:R:Y221	2.39	No	No	0	5	7
250	R:R:E182	R:R:R179	2.33	No	No	0	2	3
251	R:R:H216	R:R:R213	2.26	No	No	0	8	8
252	R:R:G277	R:R:G350	2.11	No	No	0	4	5
253	R:R:G330	R:R:P332	2.03	No	No	0	7	9
254	R:R:G194	R:R:V193	1.84	No	No	0	9	6
255	R:R:G280	R:R:V283	1.84	No	No	0	4	4
256	R:R:G323	R:R:V326	1.84	No	No	0	1	4
257	R:R:C462	R:R:I457	1.64	No	No	0	6	6
258	R:R:S341	R:R:V342	1.62	No	No	0	5	5
259	R:R:V239	R:R:V243	1.6	No	No	0	5	5
260	R:R:V338	R:R:V342	1.6	No	No	0	5	5
261	R:R:T435	R:R:V439	1.59	No	No	0	1	5
262	R:R:A234	R:R:L199	1.58	No	No	0	8	7
263	R:R:A386	R:R:L406	1.58	No	No	0	6	8
264	R:R:I376	R:R:V372	1.54	No	No	0	4	4
265	R:R:I458	R:R:V412	1.54	No	No	0	8	8
266	R:R:K388	R:R:V384	1.52	No	No	0	9	8
267	R:R:L406	R:R:V382	1.49	No	No	0	8	7
268	R:R:L436	R:R:V439	1.49	No	No	0	4	5
269	R:R:L207	R:R:T203	1.47	No	No	0	3	3
270	R:R:I381	R:R:L385	1.43	No	No	0	9	8
271	R:R:Q401	R:R:T399	1.42	No	No	0	6	6
272	R:R:Q402	R:R:T399	1.42	No	No	0	6	6
273	L:L:K13	R:R:L354	1.41	No	No	0	0	5
274	R:R:D185	R:R:M189	1.39	No	No	0	2	4
275	R:R:E391	R:R:K388	1.35	No	No	0	7	9
276	R:R:E180	R:R:R179	1.16	No	No	0	3	3
277	R:R:E182	R:R:R186	1.16	No	No	0	2	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:E4	6.41	5	1	0
2	L:L:Q6	9.69	4	0	0
3	R:R:Y191	7.6175	4	0	7
4	R:R:Y195	6.33167	6	0	7
5	R:R:F212	6.958	5	0	7
6	R:R:F230	8.15	6	0	8
7	R:R:R233	8.27833	6	1	8
8	R:R:L244	9.0325	4	3	5
9	R:R:F291	9.9025	4	0	5
10	R:R:N295	10.22	4	0	8
11	R:R:Y296	10.09	4	1	7
12	R:R:Y297	7.725	4	0	6
13	R:R:W298	14.8175	4	5	9
14	R:R:E302	10.8125	4	0	9
15	R:R:Y305	9.6925	4	0	8
16	R:R:F311	10.485	4	7	6
17	R:R:Y320	5.8225	4	0	4
18	R:R:W339	6.55	6	4	8
19	R:R:R343	10.5	4	4	8
20	R:R:W352	11.07	4	4	8
21	R:R:D353	8.3425	4	3	5
22	R:R:K360	10.5625	4	2	7
23	R:R:W361	6.32	4	0	8
24	R:R:Q364	9.048	5	2	7
25	R:R:F378	7.62	5	6	9
26	R:R:F417	7.495	6	6	9
27	R:R:H420	10.125	4	1	8
28	R:R:Y421	13.545	4	1	8
29	R:R:F424	7.535	4	1	7
30	R:R:Y429	14.775	4	2	6
31	R:R:W437	10.378	5	0	5
32	R:R:Q440	7.0225	4	1	6
33	R:R:M445	5.816	5	1	6
34	R:R:N448	7.6225	4	1	6
35	R:R:Q451	6.425	4	0	9
36	R:R:F453	6.86	4	0	6
37	R:R:C460	3.91	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Q364	R:R:Y429	16.4692	10.15	Yes	Yes	2	7	6
2	L:L:Q6	R:R:Y429	32.6585	19.16	Yes	Yes	0	0	6
3	L:L:Q6	R:R:Q440	100	5.12	Yes	Yes	0	0	6
4	R:R:E444	R:R:Q440	70.3721	5.1	No	Yes	1	7	6
5	L:L:?3	R:R:E444	72.593	16.5	No	No	1	0	7
6	L:L:?3	L:L:E4	65.3171	5.08	No	Yes	1	0	0
7	L:L:E4	R:R:R233	66.1506	6.98	Yes	Yes	1	0	8
8	L:L:Q6	R:R:M441	71.3248	6.8	Yes	No	0	0	6
9	R:R:M441	R:R:W437	69.5981	22.1	No	Yes	0	6	5
10	R:R:F184	R:R:W437	47.6987	5.01	No	Yes	0	6	5
11	L:L:?11	R:R:F184	32.9086	6.64	No	No	0	0	6
12	L:L:?11	R:R:Y245	30.9318	28.32	No	No	0	0	4
13	R:R:D353	R:R:Y245	16.4692	8.05	Yes	No	3	5	4
14	R:R:K360	R:R:Y429	10.2114	16.72	Yes	Yes	2	7	6
15	L:L:W14	R:R:F184	14.6115	4.01	No	No	0	0	6
16	R:R:Q438	R:R:W437	12.5156	7.67	No	Yes	0	4	5
17	R:R:R233	R:R:Y195	25.1206	11.32	Yes	Yes	0	8	7
18	R:R:A234	R:R:Y195	11.1045	5.34	No	Yes	0	8	7
19	R:R:F424	R:R:Q440	34.0875	9.37	Yes	Yes	1	7	6
20	R:R:F424	R:R:Y443	34.7008	7.22	Yes	No	0	7	4
21	R:R:F447	R:R:Y443	36.0941	15.47	No	No	0	5	4
22	R:R:F447	R:R:H420	37.5826	12.44	No	Yes	0	5	8
23	R:R:H420	R:R:Q451	39.1247	9.89	Yes	Yes	0	8	9
24	R:R:F230	R:R:Q451	38.9163	7.03	Yes	Yes	0	8	9
25	R:R:F230	R:R:L202	54.9092	4.87	Yes	No	0	8	9
26	R:R:F227	R:R:L202	51.9321	4.87	No	No	0	9	9
27	R:R:F227	R:R:L209	48.8955	4.87	No	No	0	9	7
28	R:R:C460	R:R:L209	41.2742	3.17	Yes	No	0	9	7
29	R:R:C460	R:R:F461	14.5639	5.59	Yes	No	0	9	8
30	R:R:F461	R:R:I457	10.9973	5.02	No	No	0	8	6
31	R:R:N295	R:R:R233	85.0432	10.85	Yes	Yes	0	8	8
32	R:R:F230	R:R:N295	81.7505	16.92	Yes	Yes	0	8	8
33	R:R:C460	R:R:I208	24.8467	3.27	Yes	No	0	9	8
34	R:R:I208	R:R:I470	23.1319	4.42	No	No	0	8	5
35	R:R:F212	R:R:I470	21.5481	5.02	Yes	No	0	7	5
36	R:R:F230	R:R:L226	77.6302	7.31	Yes	No	0	8	9
37	R:R:E302	R:R:L226	76.3501	17.23	Yes	No	0	9	9
38	R:R:E302	R:R:I222	24.6085	5.47	Yes	No	0	9	9
39	R:R:I222	R:R:Y305	21.2861	8.46	No	Yes	0	9	8
40	R:R:N295	R:R:S229	70.8425	7.45	Yes	No	0	8	9
41	R:R:S229	R:R:W298	70.0089	7.41	No	Yes	0	9	9
42	R:R:W298	R:R:W329	65.9006	25.3	Yes	No	5	9	9
43	R:R:T294	R:R:W329	65.6624	6.06	No	No	0	8	9
44	R:R:T294	R:R:Y290	10.4972	8.74	No	No	0	8	9
45	R:R:R233	R:R:Y296	10.2888	7.2	Yes	Yes	1	8	7
46	R:R:L244	R:R:Y245	12.462	17.58	Yes	No	3	5	4
47	R:R:P332	R:R:T294	58.0887	5.25	No	No	0	9	8
48	R:R:P332	R:R:Y297	56.0762	11.13	No	Yes	0	9	6
49	R:R:F335	R:R:Y297	34.7127	6.19	No	Yes	0	5	6
50	R:R:F335	R:R:I363	32.212	7.54	No	No	0	5	7
51	R:R:I363	R:R:W339	29.6517	11.74	No	Yes	0	7	8
52	R:R:W339	R:R:W352	10.0566	5.62	Yes	Yes	4	8	8
53	R:R:S370	R:R:Y297	21.6017	6.36	No	Yes	0	7	6
54	R:R:E302	R:R:L416	49.9434	11.93	Yes	No	0	9	9
55	R:R:F417	R:R:L416	40.7979	4.87	Yes	No	0	9	9
56	R:R:F315	R:R:Y305	14.415	5.16	No	Yes	0	6	8
57	R:R:F417	R:R:L306	17.791	4.87	Yes	No	0	9	9
58	R:R:I381	R:R:L306	16.0584	5.71	No	No	0	9	9
59	R:R:L300	R:R:S370	20.2322	4.5	No	No	0	8	7
60	R:R:L300	R:R:L373	17.4576	4.15	No	No	0	8	7
61	R:R:L373	R:R:L377	16.0524	6.92	No	No	0	7	7
62	R:R:H307	R:R:L377	14.6234	5.14	No	No	0	8	7
63	R:R:F311	R:R:H307	10.3126	16.97	Yes	No	7	6	8
64	R:R:F315	R:R:Y320	10.8366	8.25	No	Yes	0	6	4
65	R:R:F378	R:R:F417	17.6183	8.57	Yes	Yes	6	9	9
66	R:R:I381	R:R:L385	14.4269	1.43	No	No	0	9	8
67	R:R:L385	R:R:S409	12.6407	3	No	No	0	8	9
68	R:R:K405	R:R:S409	10.9914	4.59	No	No	0	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Q364	5.1	2	No	Yes	0	7	0	1
L:L:?1	R:R:L368	6.63	2	No	No	0	4	0	1
L:L:V2	R:R:Q364	8.6	2	No	Yes	0	7	0	1
L:L:?3	R:R:E444	16.5	1	No	No	0	7	0	1
L:L:?3	R:R:M445	5.42	1	No	Yes	0	6	0	1
L:L:E4	R:R:R233	6.98	1	Yes	Yes	0	8	0	1
L:L:E4	R:R:L292	5.3	1	Yes	No	0	6	0	1
L:L:E4	R:R:M445	8.12	1	Yes	Yes	0	6	0	1
L:L:E4	R:R:N448	6.57	1	Yes	Yes	0	6	0	1
L:L:I5	R:R:Q364	13.72	2	No	Yes	0	7	0	1
L:L:Q6	R:R:Y429	19.16	0	Yes	Yes	0	6	0	1
L:L:Q6	R:R:Q440	5.12	0	Yes	Yes	0	6	0	1
L:L:Q6	R:R:M441	6.8	0	Yes	No	0	6	0	1
L:L:M8	R:R:F288	4.98	0	No	No	0	7	0	1
L:L:M8	R:R:D353	6.93	0	No	Yes	0	5	0	1
L:L:H9	R:R:S355	8.37	2	No	No	0	7	0	1
L:L:H9	R:R:K360	7.86	2	No	Yes	0	7	0	1
L:L:H9	R:R:Y429	13.07	2	No	Yes	0	6	0	1
L:L:?11	R:R:F184	6.64	0	No	No	0	6	0	1
L:L:?11	R:R:Y245	28.32	0	No	No	0	4	0	1
L:L:A12	R:R:D353	6.18	0	No	Yes	0	5	0	1
L:L:W14	R:R:E180	13.08	0	No	No	0	3	0	1
L:L:W14	R:R:R181	7	0	No	No	0	3	0	1
R:R:E177	R:R:E180	15.22	0	No	No	1	3	2	1
R:R:D185	R:R:R181	20.25	0	No	No	2	3	2	1
R:R:F184	R:R:W437	5.01	0	No	Yes	6	5	1	2
R:R:Y191	R:R:Y195	5.96	0	Yes	Yes	7	7	2	2
R:R:M445	R:R:Y191	8.38	1	Yes	Yes	6	7	1	2
R:R:R233	R:R:Y195	11.32	1	Yes	Yes	8	7	1	2
R:R:L292	R:R:R233	7.29	1	No	Yes	6	8	1	1
R:R:N295	R:R:R233	10.85	0	Yes	Yes	8	8	2	1
R:R:R233	R:R:Y296	7.2	1	Yes	Yes	8	7	1	2
R:R:N448	R:R:R233	6.03	1	Yes	Yes	6	8	1	1
R:R:F288	R:R:K240	21.09	0	No	No	7	7	1	2
R:R:L244	R:R:Y245	17.58	3	Yes	No	5	4	2	1
R:R:D353	R:R:L244	12.21	3	Yes	Yes	5	5	1	2
R:R:D353	R:R:Y245	8.05	3	Yes	No	5	4	1	1
R:R:Y296	R:R:Y421	19.86	1	Yes	Yes	7	8	2	2
R:R:K360	R:R:S355	10.71	2	Yes	No	7	7	1	1
R:R:K360	R:R:W361	6.96	2	Yes	Yes	7	8	1	2
R:R:K360	R:R:Y429	16.72	2	Yes	Yes	7	6	1	1
R:R:Q364	R:R:W361	7.67	2	Yes	Yes	7	8	1	2
R:R:Q364	R:R:Y429	10.15	2	Yes	Yes	7	6	1	1
R:R:H420	R:R:Y421	13.07	1	Yes	Yes	8	8	2	2
R:R:H420	R:R:N448	5.1	1	Yes	Yes	8	6	2	1
R:R:N448	R:R:Y421	12.79	1	Yes	Yes	6	8	1	2
R:R:F424	R:R:Q440	9.37	1	Yes	Yes	7	6	2	1
R:R:E444	R:R:F424	7	1	No	Yes	7	7	1	2
R:R:Q440	R:R:T427	8.5	1	Yes	No	6	5	1	2
R:R:M441	R:R:W437	22.1	0	No	Yes	6	5	1	2
R:R:E444	R:R:Q440	5.1	1	No	Yes	7	6	1	1
L:L:L7	R:R:M445	4.24	0	No	Yes	0	6	0	1
L:L:W14	R:R:F184	4.01	0	No	No	0	6	0	1
L:L:A12	R:R:L354	3.15	0	No	No	0	5	0	1
L:L:M8	R:R:V285	3.04	0	No	No	0	6	0	1
R:R:I190	R:R:M445	2.92	0	No	Yes	6	6	2	1
L:L:K13	R:R:L354	1.41	0	No	No	0	5	0	1
R:R:E180	R:R:R179	1.16	0	No	No	3	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8FLT_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4.81
Number of Linked Nodes	259
Number of Links	277
Number of Hubs	37
Number of Links mediated by Hubs	136
Number of Communities	7
Number of Nodes involved in Communities	39
Number of Links involved in Communities	50

Path Summary
Number Of Nodes in MetaPath	69
Number Of Links MetaPath	68
Number of Shortest Paths	38383
Length Of Smallest Path	3
Average Path Length	14.7802
Length of Longest Path	33
Minimum Path Strength	1.42
Average Path Strength	8.74804
Maximum Path Strength	22.95
Minimum Path Correlation	0.7
Average Path Correlation	0.929529
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	50.751
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.1677
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • identical protein binding • protein homodimerization activity • protein dimerization activity • amide binding • peptide hormone binding • hormone binding • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • parathyroid hormone receptor activity • ossification • bone mineralization • biomineral tissue development • tissue development • skeletal system development • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • osteoblast development • cellular developmental process • cell differentiation • cell development • osteoblast differentiation • embryo development ending in birth or egg hatching • chordate embryonic development • embryo development • in utero embryonic development • anatomical structure maturation • cell maturation • developmental maturation • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • cell surface receptor signaling pathway • negative regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • connective tissue development • chondrocyte differentiation • cartilage development • regulation of inositol phosphate biosynthetic process • alcohol metabolic process • positive regulation of phosphate metabolic process • inositol phosphate metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • phosphate-containing compound metabolic process • polyol biosynthetic process • small molecule metabolic process • phosphorus metabolic process • regulation of carbohydrate metabolic process • regulation of biosynthetic process • carbohydrate metabolic process • polyol metabolic process • positive regulation of phosphorus metabolic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • carbohydrate biosynthetic process • primary metabolic process • positive regulation of inositol phosphate biosynthetic process • biosynthetic process • organophosphate metabolic process • organophosphate biosynthetic process • inositol phosphate biosynthetic process • alcohol biosynthetic process • metabolic process • regulation of phosphorus metabolic process • positive regulation of carbohydrate metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • tissue homeostasis • bone resorption • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • apical part of cell • plasma membrane region • apical plasma membrane • basal part of cell • basal plasma membrane • basolateral plasma membrane • receptor complex
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	AIB
PDB Residues	L:L:?1 L:L:?3
Environment Details	Open EMBL-EBI Page
Code	AIB
Name	2-aminoisobutyric acid
Synonyms	α-aminoisobutyric acid
Identifier
Formula	C4 H9 N O2
Molecular Weight	103.12
SMILES
PubChem	5245672
Formal Charge	0
Total Atoms	16
Total Chiral Atoms	0
Total Bonds	15
Total Aromatic Bonds	0


Code	HRG
PDB Residues	L:L:?11
Environment Details	Open EMBL-EBI Page
Code	HRG
Name	L-homoarginine
Synonyms	Homo-L-arginine
Identifier
Formula	C7 H16 N4 O2
Molecular Weight	188.228
SMILES
PubChem	9085
Formal Charge	0
Total Atoms	29
Total Chiral Atoms	1
Total Bonds	28
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q03431
Sequence	>8FLT_nogp_Chain_R E T R E R E V F D R L G M I Y T V G Y S V S L A S L T V A V L I L A Y F R R L H C T R N Y I H M H L F L S F M L R A V S I F V K D A V L Y S G Y A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M A F F S E K K Y L W G F T V F G W G L P A V F V A V W V S V R A T L A N T G C W D L S S G N K K W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L R E T T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M A T P Y T E V S G T L W Q V Q M H Y E M L F N S F Q G F F V A I I Y C F C N G E V Q A E I K K S W S R W T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8GW8	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371	Gs/β1/γ2	2.9	2023-06-14	doi.org/10.1038/s41586-023-06169-3
	8GW8 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371		2.9	2023-06-14	doi.org/10.1038/s41586-023-06169-3
	8JR9	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371	chim(NtGi1-Gs)/β1/γ2	2.57	2023-08-02	doi.org/10.1038/s41586-023-06467-w
	8JR9 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371		2.57	2023-08-02	doi.org/10.1038/s41586-023-06467-w
	7VVJ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVJ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVK	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.3	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVK (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.3	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVL	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVL (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVM	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVM (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVN	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVN (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	4.1	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		4.1	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	8FLQ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.55	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLQ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.55	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLR	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	2.94	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLR (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		2.94	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLS	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	3.09	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLS (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		3.09	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLT	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-	Gs/β1/γ2	3.03	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLT (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-		3.03	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLU	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-	Gs/β1/γ2	2.76	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLU (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-		2.76	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8HA0	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	2.62	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HA0 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.62	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	chim(NtGi1-Gs)/β1/γ2	3.25	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.25	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	3.76	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.76	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	6FJ3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	-	2.5	2018-11-21	doi.org/10.1038/s41594-018-0151-4
	6NBF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	3	2019-04-17	doi.org/10.1126/science.aav7942
	6NBF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		3	2019-04-17	doi.org/10.1126/science.aav7942
	6NBH	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	3.5	2019-04-17	doi.org/10.1126/science.aav7942
	6NBH (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		3.5	2019-04-17	doi.org/10.1126/science.aav7942
	6NBI	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	4	2019-04-17	doi.org/10.1126/science.aav7942
	6NBI (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		4	2019-04-17	doi.org/10.1126/science.aav7942
	9B5Y	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-	chim(NtGi1-Gq)/β1/γ2	3.49	2025-03-19	doi.org/10.1073/pnas.2426178122
	9B5Y (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-		3.49	2025-03-19	doi.org/10.1073/pnas.2426178122
	7Y35	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	2.9	2023-07-05	To be published
	7Y35 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		2.9	2023-07-05	To be published
	7Y36	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Teriparatide	-	Gs/β1/γ2	2.8	2023-07-05	To be published
	7Y36 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Teriparatide	-		2.8	2023-07-05	To be published
	9JR2	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	To be published
	9JR2 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	To be published
	9JR3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	To be published
	9JR3 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	To be published

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