psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:V2	R:R:Y296	3.79	No	Yes	0	0	7
2	L:L:V2	R:R:Q364	10.03	No	Yes	0	0	7
3	L:L:S3	R:R:E444	11.5	No	No	0	0	7
4	L:L:E4	R:R:Y195	7.86	Yes	Yes	1	0	7
5	L:L:E4	R:R:R233	3.49	Yes	Yes	1	0	8
6	L:L:E4	R:R:I237	4.1	Yes	Yes	1	0	7
7	L:L:E4	R:R:M445	6.77	Yes	No	0	0	6
8	L:L:E4	R:R:N448	3.94	Yes	Yes	1	0	6
9	L:L:H5	L:L:L8	3.86	Yes	No	1	0	0
10	L:L:H5	L:L:H9	20.3	Yes	Yes	1	0	0
11	L:L:H5	R:R:L289	11.57	Yes	Yes	1	0	7
12	L:L:H5	R:R:Q364	11.13	Yes	Yes	1	0	7
13	L:L:D10	L:L:Q6	7.83	No	Yes	1	0	0
14	L:L:Q6	R:R:Y429	12.4	Yes	Yes	1	0	6
15	L:L:Q6	R:R:W437	4.38	Yes	Yes	1	0	5
16	L:L:Q6	R:R:Q440	6.4	Yes	Yes	1	0	6
17	L:L:Q6	R:R:M441	6.8	Yes	Yes	1	0	6
18	L:L:L7	R:R:L187	4.15	No	Yes	0	0	5
19	L:L:H9	L:L:L8	3.86	Yes	No	1	0	0
20	L:L:L8	R:R:D353	10.86	No	Yes	0	0	5
21	L:L:H9	R:R:S355	9.76	Yes	No	1	0	7
22	L:L:H9	R:R:K360	6.55	Yes	Yes	1	0	7
23	L:L:H9	R:R:Y429	9.8	Yes	Yes	1	0	6
24	L:L:D10	R:R:V432	5.84	No	Yes	1	0	5
25	L:L:D10	R:R:W437	8.93	No	Yes	1	0	5
26	L:L:K11	R:R:F184	3.72	No	Yes	0	0	6
27	L:L:K11	R:R:Y245	16.72	No	No	0	0	4
28	L:L:G12	R:R:D353	3.35	No	Yes	0	0	5
29	L:L:D17	L:L:K13	5.53	No	No	0	0	0
30	L:L:K13	R:R:V31	6.07	No	No	0	0	6
31	L:L:S14	R:R:F184	5.28	No	Yes	0	0	6
32	L:L:I15	L:L:R19	5.01	No	No	0	0	0
33	L:L:I15	R:R:R181	6.26	No	No	0	0	3
34	L:L:Q16	R:R:T33	7.09	No	No	0	0	7
35	L:L:Q16	R:R:L354	11.98	No	No	0	0	5
36	L:L:D17	L:L:R20	8.34	No	Yes	0	0	0
37	L:L:R20	R:R:Q37	5.84	Yes	No	0	0	7
38	L:L:R20	R:R:Y136	6.17	Yes	No	4	0	4
39	L:L:R20	R:R:D137	11.91	Yes	No	4	0	5
40	L:L:R21	R:R:D137	7.15	No	No	0	0	5
41	L:L:F23	L:L:L27	8.53	No	No	2	0	0
42	L:L:F23	R:R:K34	7.44	No	No	2	0	4
43	L:L:F23	R:R:I38	6.28	No	No	2	0	7
44	L:L:I28	L:L:L24	5.71	No	No	2	0	0
45	L:L:L24	R:R:I135	5.71	No	Yes	2	0	7
46	L:L:L24	R:R:F138	6.09	No	Yes	2	0	4
47	L:L:H26	L:L:L27	9	No	No	2	0	0
48	L:L:E30	L:L:H26	4.92	No	No	2	0	0
49	L:L:E30	L:L:L27	3.98	No	No	2	0	0
50	L:L:I28	R:R:F138	6.28	No	Yes	2	0	4
51	L:L:E30	L:L:I31	8.2	No	Yes	2	0	0
52	L:L:I31	R:R:D113	12.59	Yes	No	0	0	9
53	L:L:I31	R:R:I115	5.89	Yes	Yes	2	0	5
54	L:L:I31	R:R:Y167	9.67	Yes	Yes	2	0	5
55	L:L:H32	R:R:N166	12.75	No	Yes	2	0	7
56	L:L:H32	R:R:Y167	9.8	No	Yes	2	0	5
57	L:L:H32	R:R:S168	5.58	No	No	2	0	6
58	R:R:E36	R:R:M32	8.12	No	No	0	6	6
59	R:R:M32	R:R:Y136	3.59	No	No	0	6	4
60	R:R:E35	R:R:T33	7.06	No	No	0	5	7
61	R:R:I38	R:R:K34	5.82	No	No	2	7	4
62	R:R:E36	R:R:L40	5.3	No	No	0	6	5
63	R:R:I135	R:R:Q37	8.23	Yes	No	0	7	7
64	R:R:F39	R:R:L40	3.65	No	No	0	7	5
65	R:R:R43	R:R:Y134	9.26	No	No	0	4	5
66	R:R:Q45	R:R:W112	15.33	No	Yes	5	7	7
67	R:R:H114	R:R:Q45	3.71	No	No	5	4	7
68	R:R:C48	R:R:L52	3.17	Yes	No	0	8	4
69	R:R:C48	R:R:W112	11.75	Yes	Yes	0	8	7
70	R:R:C117	R:R:C48	7.28	No	Yes	0	9	8
71	R:R:K50	R:R:K53	5.75	No	No	0	4	5
72	R:R:L52	R:R:P110	3.28	No	No	0	4	6
73	R:R:G105	R:R:P123	4.06	No	No	0	5	7
74	R:R:P107	R:R:R106	5.76	No	No	0	3	1
75	R:R:L120	R:R:P107	4.93	No	No	0	4	3
76	R:R:P107	R:R:P123	5.84	No	No	0	3	7
77	R:R:C108	R:R:C148	7.28	No	No	0	9	9
78	R:R:C108	R:R:W154	16.98	No	Yes	0	9	9
79	R:R:L109	R:R:P110	3.28	No	No	0	5	6
80	R:R:L109	R:R:W154	4.56	No	Yes	0	5	9
81	R:R:L120	R:R:P110	8.21	No	No	0	4	6
82	R:R:E111	R:R:R146	6.98	No	Yes	2	7	8
83	R:R:E111	R:R:W154	7.63	No	Yes	2	7	9
84	R:R:E111	R:R:T163	4.23	No	No	0	7	5
85	R:R:H114	R:R:W112	5.29	No	Yes	5	4	7
86	R:R:D113	R:R:R146	7.15	No	Yes	0	9	8
87	R:R:I115	R:R:L116	4.28	Yes	Yes	2	5	5
88	R:R:I115	R:R:P132	3.39	Yes	Yes	2	5	9
89	R:R:F138	R:R:I115	5.02	Yes	Yes	2	4	5
90	R:R:I115	R:R:Y167	13.3	Yes	Yes	2	5	5
91	R:R:L116	R:R:W118	4.56	Yes	Yes	2	5	9
92	R:R:L116	R:R:V129	4.47	Yes	Yes	2	5	5
93	R:R:L116	R:R:P132	11.49	Yes	Yes	2	5	9
94	R:R:V129	R:R:W118	7.36	Yes	Yes	2	5	9
95	R:R:R146	R:R:W118	24.99	Yes	Yes	2	8	9
96	R:R:W118	R:R:Y167	4.82	Yes	Yes	2	9	5
97	R:R:C148	R:R:G121	3.92	No	No	0	9	7
98	R:R:G121	R:R:W154	4.22	No	Yes	0	7	9
99	R:R:E125	R:R:V126	4.28	No	No	0	5	4
100	R:R:P130	R:R:V129	3.53	No	Yes	0	5	5
101	R:R:H143	R:R:P130	9.15	No	No	0	3	5
102	R:R:C131	R:R:C170	7.28	No	No	0	9	9
103	R:R:I135	R:R:P132	5.08	Yes	Yes	2	7	9
104	R:R:F138	R:R:P132	7.22	Yes	Yes	2	4	9
105	R:R:D133	R:R:H140	8.82	No	No	0	2	3
106	R:R:F138	R:R:I135	18.84	Yes	Yes	2	4	7
107	R:R:D137	R:R:Y136	5.75	No	No	4	5	4
108	R:R:C170	R:R:F138	11.17	No	Yes	0	9	4
109	R:R:K141	R:R:N139	15.39	No	No	0	3	4
110	R:R:F173	R:R:N139	14.5	No	No	0	3	4
111	R:R:E169	R:R:G142	3.27	No	No	0	5	5
112	R:R:H143	R:R:Y145	3.27	No	Yes	0	3	4
113	R:R:A144	R:R:Y167	4	No	Yes	0	7	5
114	R:R:N166	R:R:Y145	8.14	Yes	Yes	2	7	4
115	R:R:E169	R:R:Y145	12.35	No	Yes	2	5	4
116	R:R:R146	R:R:W154	8	Yes	Yes	2	8	9
117	R:R:A165	R:R:R146	4.15	No	Yes	2	7	8
118	R:R:R146	R:R:Y167	5.14	Yes	Yes	2	8	5
119	R:R:E155	R:R:R147	11.63	No	No	2	4	3
120	R:R:R147	R:R:W164	10	No	Yes	2	3	5
121	R:R:D149	R:R:R150	16.68	No	No	0	5	1
122	R:R:N151	R:R:R150	15.67	No	No	0	5	1
123	R:R:E155	R:R:W164	5.45	No	Yes	2	4	5
124	R:R:P158	R:R:V157	5.3	No	No	0	4	4
125	R:R:A165	R:R:Y167	5.34	No	Yes	2	7	5
126	R:R:N166	R:R:S168	8.94	Yes	No	2	7	6
127	R:R:E169	R:R:N166	3.94	No	Yes	2	5	7
128	R:R:L174	R:R:V171	5.96	No	No	0	3	3
129	R:R:F173	R:R:K172	6.2	No	No	0	3	3
130	R:R:E177	R:R:E180	10.15	No	Yes	0	1	3
131	R:R:E180	R:R:R179	3.49	Yes	No	0	3	3
132	R:R:Q438	R:R:R179	4.67	No	No	0	4	3
133	R:R:E180	R:R:V432	4.28	Yes	Yes	0	3	5
134	R:R:D185	R:R:R181	5.96	No	No	0	2	3
135	R:R:E182	R:R:R186	3.49	No	No	0	2	5
136	R:R:F184	R:R:V432	6.55	Yes	Yes	1	6	5
137	R:R:F184	R:R:W437	6.01	Yes	Yes	1	6	5
138	R:R:H442	R:R:R186	6.77	No	No	0	5	5
139	R:R:L187	R:R:W437	3.42	Yes	Yes	1	5	5
140	R:R:L187	R:R:M441	5.65	Yes	Yes	1	5	6
141	R:R:H442	R:R:L187	6.43	No	Yes	0	5	5
142	R:R:G188	R:R:Y191	8.69	No	Yes	0	5	7
143	R:R:I190	R:R:M445	4.37	No	No	0	6	6
144	R:R:Y191	R:R:Y195	3.97	Yes	Yes	0	7	7
145	R:R:D241	R:R:Y191	9.2	Yes	Yes	0	8	7
146	R:R:M445	R:R:Y191	8.38	No	Yes	0	6	7
147	R:R:G194	R:R:S449	3.71	No	No	1	9	9
148	R:R:F450	R:R:G194	9.03	Yes	No	1	7	9
149	R:R:R233	R:R:Y195	6.17	Yes	Yes	1	8	7
150	R:R:A234	R:R:Y195	5.34	No	Yes	0	8	7
151	R:R:I237	R:R:Y195	6.04	Yes	Yes	1	7	7
152	R:R:S449	R:R:Y195	3.82	No	Yes	1	9	7
153	R:R:F238	R:R:S196	5.28	No	No	0	7	7
154	R:R:F453	R:R:V197	5.24	Yes	No	0	6	5
155	R:R:G452	R:R:S198	3.71	No	No	0	9	9
156	R:R:L199	R:R:V235	4.47	No	No	0	7	4
157	R:R:F453	R:R:S201	5.28	Yes	No	0	6	8
158	R:R:A456	R:R:S201	3.42	No	No	0	8	8
159	R:R:F227	R:R:L202	6.09	No	Yes	0	9	9
160	R:R:F230	R:R:L202	6.09	Yes	Yes	1	8	9
161	R:R:G452	R:R:L202	3.42	No	Yes	1	9	9
162	R:R:F461	R:R:V204	3.93	No	No	0	8	5
163	R:R:A205	R:R:C460	3.61	No	Yes	0	9	9
164	R:R:C460	R:R:I208	3.27	Yes	No	0	9	8
165	R:R:L209	R:R:N220	6.87	No	No	0	7	9
166	R:R:L209	R:R:M224	5.65	No	No	0	7	5
167	R:R:C460	R:R:L209	3.17	Yes	No	0	9	7
168	R:R:F212	R:R:Y211	12.38	Yes	No	0	7	2
169	R:R:F212	R:R:L215	7.31	Yes	Yes	7	7	9
170	R:R:E469	R:R:F212	9.33	No	Yes	7	9	7
171	R:R:F212	R:R:S473	5.28	Yes	No	0	7	4
172	R:R:E469	R:R:R214	12.79	No	No	0	9	7
173	R:R:E465	R:R:L215	5.3	No	Yes	0	9	9
174	R:R:L215	R:R:V466	4.47	Yes	No	0	9	9
175	R:R:E469	R:R:L215	3.98	No	Yes	7	9	9
176	R:R:H216	R:R:Y221	8.71	No	No	0	8	7
177	R:R:T218	R:R:Y305	8.74	No	Yes	0	7	8
178	R:R:E317	R:R:T218	12.7	No	No	0	6	7
179	R:R:L321	R:R:T218	8.84	No	No	0	6	7
180	R:R:N220	R:R:R219	8.44	No	Yes	6	9	9
181	R:R:H223	R:R:R219	7.9	Yes	Yes	6	9	9
182	R:R:E465	R:R:R219	3.49	No	Yes	0	9	9
183	R:R:H223	R:R:N220	3.83	Yes	No	6	9	9
184	R:R:L321	R:R:Y221	4.69	No	No	0	6	7
185	R:R:I222	R:R:W298	3.52	No	Yes	0	9	9
186	R:R:E302	R:R:I222	6.83	Yes	No	0	9	9
187	R:R:I222	R:R:Y305	9.67	No	Yes	0	9	8
188	R:R:E302	R:R:H223	12.31	Yes	Yes	0	9	9
189	R:R:H223	R:R:Y459	3.27	Yes	Yes	0	9	8
190	R:R:H225	R:R:W298	16.93	No	Yes	1	8	9
191	R:R:H225	R:R:T325	9.58	No	No	1	8	5
192	R:R:H225	R:R:W329	6.35	No	Yes	1	8	9
193	R:R:F230	R:R:L226	7.31	Yes	No	0	8	9
194	R:R:E302	R:R:L226	15.9	Yes	No	0	9	9
195	R:R:F227	R:R:V455	3.93	No	No	0	9	9
196	R:R:L228	R:R:L232	4.15	No	No	0	4	8
197	R:R:L228	R:R:W329	4.56	No	Yes	0	4	9
198	R:R:N295	R:R:S229	7.45	Yes	No	0	8	9
199	R:R:S229	R:R:W298	7.41	No	Yes	0	9	9
200	R:R:F230	R:R:N295	18.12	Yes	Yes	1	8	8
201	R:R:F230	R:R:I299	5.02	Yes	Yes	1	8	9
202	R:R:F230	R:R:Q451	7.03	Yes	Yes	1	8	9
203	R:R:F230	R:R:G452	9.03	Yes	No	1	8	9
204	R:R:F291	R:R:L232	14.61	Yes	No	0	5	8
205	R:R:L292	R:R:R233	9.72	No	Yes	1	6	8
206	R:R:N295	R:R:R233	15.67	Yes	Yes	1	8	8
207	R:R:R233	R:R:Y296	13.38	Yes	Yes	1	8	7
208	R:R:R233	R:R:Y421	4.12	Yes	Yes	1	8	8
209	R:R:N448	R:R:R233	3.62	Yes	Yes	1	6	8
210	R:R:F288	R:R:S236	3.96	Yes	No	0	7	7
211	R:R:F291	R:R:S236	6.61	Yes	No	0	5	7
212	R:R:D241	R:R:I237	4.2	Yes	Yes	0	8	7
213	R:R:F288	R:R:I237	5.02	Yes	Yes	0	7	7
214	R:R:D241	R:R:K240	6.91	Yes	No	0	8	7
215	R:R:F288	R:R:K240	14.89	Yes	No	0	7	7
216	R:R:D241	R:R:Y245	3.45	Yes	No	0	8	4
217	R:R:C281	R:R:L244	6.35	No	No	8	9	5
218	R:R:C351	R:R:L244	3.17	No	No	8	9	5
219	R:R:D353	R:R:L244	8.14	Yes	No	0	5	5
220	R:R:D353	R:R:Y245	10.34	Yes	No	0	5	4
221	R:R:C281	R:R:C351	7.28	No	No	8	9	9
222	R:R:N348	R:R:R282	4.82	No	No	0	7	8
223	R:R:R282	R:R:W352	23.99	No	Yes	0	8	8
224	R:R:F287	R:R:V283	3.93	No	No	0	3	4
225	R:R:T286	R:R:V340	4.76	No	No	1	7	5
226	R:R:T286	R:R:W352	4.85	No	Yes	1	7	8
227	R:R:F287	R:R:F291	5.36	No	Yes	0	3	5
228	R:R:F288	R:R:L289	6.09	Yes	Yes	0	7	7
229	R:R:L289	R:R:W339	5.69	Yes	Yes	1	7	8
230	R:R:I363	R:R:L289	5.71	No	Yes	1	7	7
231	R:R:F291	R:R:Y290	7.22	Yes	Yes	0	5	9
232	R:R:T294	R:R:Y290	8.74	No	Yes	1	8	9
233	R:R:P332	R:R:Y290	4.17	Yes	Yes	1	9	9
234	R:R:A333	R:R:Y290	5.34	No	Yes	0	5	9
235	R:R:V336	R:R:Y290	6.31	No	Yes	0	7	9
236	R:R:L292	R:R:Y296	5.86	No	Yes	1	6	7
237	R:R:A293	R:R:I367	3.25	No	No	0	6	7
238	R:R:T294	R:R:W329	6.06	No	Yes	1	8	9
239	R:R:P332	R:R:T294	5.25	Yes	No	1	9	8
240	R:R:I299	R:R:N295	5.66	Yes	Yes	1	9	8
241	R:R:I367	R:R:Y296	9.67	No	Yes	0	7	7
242	R:R:I371	R:R:Y296	4.84	No	Yes	1	7	7
243	R:R:Y296	R:R:Y421	16.88	Yes	Yes	1	7	8
244	R:R:F327	R:R:Y297	6.19	No	Yes	1	5	6
245	R:R:L331	R:R:Y297	9.38	Yes	Yes	1	4	6
246	R:R:P332	R:R:Y297	5.56	Yes	Yes	1	9	6
247	R:R:F335	R:R:Y297	6.19	Yes	Yes	1	5	6
248	R:R:S370	R:R:Y297	6.36	No	Yes	0	7	6
249	R:R:V301	R:R:W298	8.58	No	Yes	0	8	9
250	R:R:T325	R:R:W298	6.06	No	Yes	1	5	9
251	R:R:G328	R:R:W298	4.22	No	Yes	0	9	9
252	R:R:W298	R:R:W329	22.49	Yes	Yes	1	9	9
253	R:R:I299	R:R:N374	4.25	Yes	No	0	9	9
254	R:R:I299	R:R:Q451	5.49	Yes	Yes	1	9	9
255	R:R:L300	R:R:L304	5.54	Yes	No	0	8	5
256	R:R:L300	R:R:S370	4.5	Yes	No	0	8	7
257	R:R:L300	R:R:L373	6.92	Yes	No	0	8	7
258	R:R:L300	R:R:N374	6.87	Yes	No	0	8	9
259	R:R:F324	R:R:V301	3.93	No	No	0	7	8
260	R:R:E302	R:R:L416	9.28	Yes	No	0	9	9
261	R:R:F417	R:R:G303	6.02	Yes	No	0	9	9
262	R:R:F324	R:R:L304	3.65	No	No	0	7	5
263	R:R:L309	R:R:Y305	14.07	No	Yes	0	8	8
264	R:R:I381	R:R:L306	5.71	No	No	0	9	9
265	R:R:F311	R:R:H307	19.23	Yes	No	9	6	8
266	R:R:H307	R:R:L377	3.86	No	No	0	8	7
267	R:R:H307	R:R:N380	6.38	No	No	9	8	8
268	R:R:F315	R:R:S308	7.93	No	No	0	6	7
269	R:R:F311	R:R:I310	7.54	Yes	No	0	6	8
270	R:R:F311	R:R:N380	7.25	Yes	No	9	6	8
271	R:R:F311	R:R:V384	3.93	Yes	No	0	6	8
272	R:R:F315	R:R:Y320	15.47	No	No	0	6	4
273	R:R:S316	R:R:Y320	12.72	No	No	0	7	4
274	R:R:G323	R:R:W322	5.63	No	No	0	1	3
275	R:R:V326	R:R:W322	9.81	No	No	0	4	3
276	R:R:F327	R:R:G328	6.02	No	No	0	5	9
277	R:R:F327	R:R:L331	6.09	No	Yes	1	5	4
278	R:R:L331	R:R:P332	3.28	Yes	Yes	1	4	9
279	R:R:F335	R:R:P332	4.33	Yes	Yes	1	5	9
280	R:R:F335	R:R:I363	6.28	Yes	No	1	5	7
281	R:R:F335	R:R:P366	18.78	Yes	No	0	5	9
282	R:R:V340	R:R:W339	3.68	No	Yes	1	5	8
283	R:R:W339	R:R:W352	4.69	Yes	Yes	1	8	8
284	R:R:K359	R:R:W339	4.64	Yes	Yes	1	3	8
285	R:R:I362	R:R:W339	5.87	No	Yes	0	8	8
286	R:R:I363	R:R:W339	14.09	No	Yes	1	7	8
287	R:R:V340	R:R:W352	3.68	No	Yes	1	5	8
288	R:R:S341	R:R:V342	3.23	No	No	0	5	5
289	R:R:K359	R:R:V342	6.07	Yes	No	0	3	5
290	R:R:I362	R:R:V342	4.61	No	No	0	8	5
291	R:R:R343	R:R:W352	19.99	Yes	Yes	1	8	8
292	R:R:R343	R:R:S356	9.22	Yes	No	1	8	4
293	R:R:K359	R:R:R343	4.95	Yes	Yes	1	3	8
294	R:R:K359	R:R:L346	4.23	Yes	No	0	3	3
295	R:R:K360	R:R:S355	4.59	Yes	No	1	7	7
296	R:R:K359	R:R:S356	10.71	Yes	No	1	3	4
297	R:R:N358	R:R:W361	6.78	No	Yes	0	4	8
298	R:R:K360	R:R:W361	6.96	Yes	Yes	1	7	8
299	R:R:K360	R:R:Q364	4.07	Yes	Yes	1	7	7
300	R:R:K360	R:R:Y429	14.33	Yes	Yes	1	7	6
301	R:R:Q364	R:R:W361	8.76	Yes	Yes	1	7	8
302	R:R:V365	R:R:W361	6.13	No	Yes	0	5	8
303	R:R:Q364	R:R:Y429	10.15	Yes	Yes	1	7	6
304	R:R:P366	R:R:V365	3.53	No	No	0	9	5
305	R:R:I371	R:R:Y421	7.25	No	Yes	1	7	8
306	R:R:I371	R:R:M425	7.29	No	Yes	0	7	6
307	R:R:F417	R:R:N374	7.25	Yes	No	0	9	9
308	R:R:F375	R:R:I379	3.77	No	No	0	7	5
309	R:R:F375	R:R:I422	13.82	No	No	0	7	5
310	R:R:F378	R:R:V382	7.87	Yes	No	3	9	7
311	R:R:F378	R:R:T410	5.19	Yes	No	3	9	9
312	R:R:F378	R:R:L413	6.09	Yes	No	3	9	9
313	R:R:F378	R:R:M414	3.73	Yes	No	3	9	8
314	R:R:F378	R:R:F417	9.65	Yes	Yes	3	9	9
315	R:R:F378	R:R:V419	11.8	Yes	No	3	9	7
316	R:R:N380	R:R:R383	7.23	No	No	0	8	8
317	R:R:T410	R:R:V382	3.17	No	No	3	9	7
318	R:R:R383	R:R:V384	3.92	No	No	0	8	8
319	R:R:R390	R:R:T387	9.06	No	No	0	6	7
320	R:R:E391	R:R:T387	5.64	No	No	0	7	7
321	R:R:L389	R:R:Q402	3.99	No	No	0	8	6
322	R:R:R400	R:R:R404	17.06	No	No	0	8	6
323	R:R:K405	R:R:S409	4.59	No	No	0	8	9
324	R:R:L407	R:R:L411	5.54	No	No	0	8	8
325	R:R:K408	R:R:V412	4.55	No	No	0	8	8
326	R:R:F417	R:R:L413	8.53	Yes	No	3	9	9
327	R:R:L413	R:R:Y459	3.52	No	Yes	0	9	8
328	R:R:M414	R:R:V419	7.61	No	No	3	8	7
329	R:R:I458	R:R:P415	5.08	No	No	0	8	9
330	R:R:F417	R:R:L416	4.87	Yes	No	0	9	9
331	R:R:L416	R:R:Y459	22.27	No	Yes	0	9	8
332	R:R:G418	R:R:H420	3.18	No	Yes	1	9	8
333	R:R:G418	R:R:Q451	3.29	No	Yes	1	9	9
334	R:R:H420	R:R:Y421	20.69	Yes	Yes	1	8	8
335	R:R:H420	R:R:Y443	3.27	Yes	Yes	1	8	4
336	R:R:F447	R:R:H420	15.84	No	Yes	1	5	8
337	R:R:H420	R:R:N448	8.93	Yes	Yes	1	8	6
338	R:R:H420	R:R:Q451	11.13	Yes	Yes	1	8	9
339	R:R:N448	R:R:Y421	16.28	Yes	Yes	1	6	8
340	R:R:Q451	R:R:Y421	7.89	Yes	Yes	1	9	8
341	R:R:F424	R:R:V423	6.55	Yes	No	1	7	6
342	R:R:V423	R:R:Y443	7.57	No	Yes	1	6	4
343	R:R:F424	R:R:T427	5.19	Yes	Yes	1	7	5
344	R:R:F424	R:R:Q440	11.71	Yes	Yes	1	7	6
345	R:R:F424	R:R:Y443	7.22	Yes	Yes	1	7	4
346	R:R:P428	R:R:T427	3.5	No	Yes	0	7	5
347	R:R:L436	R:R:T427	4.42	No	Yes	0	4	5
348	R:R:Q440	R:R:T427	8.5	Yes	Yes	1	6	5
349	R:R:P428	R:R:T430	3.5	No	No	0	7	5
350	R:R:L436	R:R:T430	7.37	No	No	0	4	5
351	R:R:T430	R:R:W437	3.64	No	Yes	0	5	5
352	R:R:V432	R:R:W437	14.71	Yes	Yes	1	5	5
353	R:R:Q438	R:R:W437	3.29	No	Yes	0	4	5
354	R:R:M441	R:R:W437	20.94	Yes	Yes	1	6	5
355	R:R:M441	R:R:Q440	5.44	Yes	Yes	1	6	6
356	R:R:E444	R:R:Y443	3.37	No	Yes	0	7	4
357	R:R:F447	R:R:Y443	17.54	No	Yes	1	5	4
358	R:R:E444	R:R:N448	10.52	No	Yes	0	7	6
359	R:R:F447	R:R:L446	3.65	No	No	0	5	5
360	R:R:F450	R:R:L446	4.87	Yes	No	0	7	5
361	R:R:F450	R:R:S449	5.28	Yes	No	1	7	9
362	R:R:F450	R:R:F454	5.36	Yes	No	0	7	6
363	R:R:F453	R:R:F454	6.43	Yes	No	0	6	6
364	R:R:F453	R:R:I457	11.3	Yes	No	0	6	6
365	R:R:I458	R:R:Y459	7.25	No	Yes	0	8	8
366	R:R:C460	R:R:F461	6.98	Yes	No	0	9	8
367	R:R:G464	R:R:N463	3.39	No	No	0	7	9
368	R:R:E465	R:R:N463	5.26	No	No	0	9	9
369	R:R:N463	R:R:V466	7.39	No	No	0	9	9
370	R:R:K471	R:R:W474	4.64	No	No	0	5	5
371	R:R:K472	R:R:R476	19.8	No	No	0	7	7
372	R:R:T478	R:R:W474	9.7	No	No	0	4	5
373	R:R:A386	R:R:L406	3.15	No	No	0	6	8
374	R:R:A344	R:R:N348	3.13	No	No	0	4	7
375	R:R:F238	R:R:Y195	3.09	No	Yes	0	7	7
376	R:R:F315	R:R:Y305	3.09	No	Yes	0	6	8
377	L:L:I28	R:R:V171	3.07	No	No	0	0	3
378	R:R:I362	R:R:V338	3.07	No	No	0	8	5
379	R:R:K472	R:R:S475	3.06	No	No	0	7	4
380	R:R:M231	R:R:V206	3.04	No	No	0	8	5
381	R:R:M425	R:R:V372	3.04	Yes	No	0	6	4
382	R:R:K388	R:R:V384	3.04	No	No	0	9	8
383	R:R:M231	R:R:T203	3.01	No	No	0	8	3
384	R:R:G152	R:R:R106	3	No	No	0	9	1
385	R:R:L479	R:R:S475	3	No	No	0	4	4
386	L:L:V2	R:R:L368	2.98	No	No	0	0	4
387	R:R:L289	R:R:V285	2.98	Yes	No	0	7	6
388	R:R:L331	R:R:V334	2.98	Yes	No	0	4	4
389	R:R:L199	R:R:T203	2.95	No	No	0	7	3
390	R:R:L346	R:R:T345	2.95	No	No	0	3	3
391	R:R:I422	R:R:M425	2.92	No	Yes	0	5	6
392	L:L:I15	L:L:K11	2.91	No	No	0	0	0
393	R:R:E180	R:R:S433	2.87	Yes	No	0	3	3
394	R:R:I310	R:R:L306	2.85	No	No	0	8	9
395	R:R:L202	R:R:M231	2.83	Yes	No	0	9	8
396	R:R:Q401	R:R:T399	2.83	No	No	0	6	6
397	R:R:E177	R:R:T175	2.82	No	No	0	1	1
398	R:R:H442	R:R:V183	2.77	No	No	0	5	4
399	R:R:L304	R:R:L377	2.77	No	No	0	5	7
400	R:R:A347	R:R:R343	2.77	No	Yes	0	7	8
401	R:R:L389	R:R:L406	2.77	No	No	0	8	8
402	L:L:A1	R:R:Y429	2.67	No	Yes	0	0	6
403	R:R:A44	R:R:Y134	2.67	No	No	0	7	5
404	R:R:A128	R:R:Y145	2.67	No	Yes	0	5	4
405	R:R:H42	R:R:I38	2.65	No	No	0	4	7
406	R:R:F424	R:R:V439	2.62	Yes	No	0	7	5
407	R:R:F212	R:R:I470	2.51	Yes	No	0	7	5
408	R:R:T192	R:R:Y191	2.5	No	Yes	0	7	7
409	R:R:V127	R:R:W154	2.45	No	Yes	0	7	9
410	R:R:V157	R:R:W164	2.45	No	Yes	0	4	5
411	L:L:L18	R:R:R181	2.43	No	No	0	0	3
412	R:R:N161	R:R:R162	2.41	No	No	0	7	3
413	R:R:K319	R:R:Y320	2.39	No	No	0	6	4
414	R:R:Q402	R:R:R390	2.34	No	No	0	6	6
415	R:R:K319	R:R:W322	2.32	No	No	0	6	3
416	R:R:L41	R:R:W112	2.28	No	Yes	0	8	7
417	R:R:G277	R:R:G350	2.11	No	No	0	4	5
418	R:R:G330	R:R:P332	2.03	No	Yes	0	7	9
419	R:R:C351	R:R:G277	1.96	No	No	0	9	4
420	R:R:A122	R:R:P123	1.87	No	No	0	1	7
421	R:R:G357	R:R:S355	1.86	No	No	0	6	7
422	R:R:G194	R:R:V193	1.84	No	No	0	9	6
423	R:R:G280	R:R:V283	1.84	No	No	0	4	4
424	R:R:G350	R:R:T349	1.82	No	No	0	5	5
425	R:R:P119	R:R:V129	1.77	No	Yes	0	6	5
426	L:L:G12	R:R:L354	1.71	No	No	0	0	5
427	R:R:G142	R:R:N139	1.7	No	No	0	5	4
428	R:R:A284	R:R:V243	1.7	No	No	0	6	5
429	R:R:C462	R:R:I457	1.64	No	No	0	6	6
430	R:R:G464	R:R:Q467	1.64	No	No	0	7	8
431	R:R:A210	R:R:M224	1.61	No	No	0	4	5
432	R:R:A426	R:R:M425	1.61	No	Yes	0	5	6
433	R:R:V239	R:R:V243	1.6	No	No	0	5	5
434	R:R:T435	R:R:V439	1.59	No	No	0	1	5
435	R:R:I376	R:R:V372	1.54	No	No	0	4	4
436	R:R:I458	R:R:V412	1.54	No	No	0	8	8
437	R:R:C48	R:R:Q47	1.53	Yes	No	0	8	6
438	R:R:M312	R:R:S308	1.53	No	No	0	5	7
439	R:R:A44	R:R:Q47	1.52	No	No	0	7	6
440	R:R:M189	R:R:V193	1.52	No	No	0	4	6
441	R:R:A122	R:R:E125	1.51	No	No	0	1	5
442	R:R:L385	R:R:S409	1.5	No	No	0	8	9
443	R:R:L406	R:R:V382	1.49	No	No	0	8	7
444	R:R:L479	R:R:T478	1.47	No	No	0	4	4
445	L:L:A29	L:L:H25	1.46	No	No	0	0	0
446	R:R:N176	R:R:T178	1.46	No	No	0	3	3
447	L:L:Q16	R:R:V31	1.43	No	No	0	0	6
448	R:R:Q402	R:R:T399	1.42	No	No	0	6	6
449	R:R:K405	R:R:L389	1.41	No	No	0	8	8
450	R:R:L411	R:R:M414	1.41	No	No	0	8	8
451	R:R:C217	R:R:R219	1.39	No	Yes	0	8	9
452	R:R:H160	R:R:N161	1.28	No	No	0	4	7
453	R:R:N166	R:R:W164	1.13	Yes	Yes	2	7	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:E4	5.232	5	1	0
2	L:L:H5	11.715	4	1	0
3	L:L:Q6	7.562	5	1	0
4	L:L:H9	10.054	5	1	0
5	L:L:R20	8.065	4	4	0
6	L:L:I31	9.0875	4	2	0
7	R:R:C48	5.9325	4	0	8
8	R:R:W112	8.6625	4	5	7
9	R:R:I115	6.376	5	2	5
10	R:R:L116	6.2	4	2	5
11	R:R:W118	10.4325	4	2	9
12	R:R:V129	4.2825	4	2	5
13	R:R:P132	6.795	4	2	9
14	R:R:I135	9.465	4	2	7
15	R:R:F138	9.10333	6	2	4
16	R:R:Y145	6.6075	4	2	4
17	R:R:R146	9.40167	6	2	8
18	R:R:W154	7.30667	6	2	9
19	R:R:W164	4.7575	4	2	5
20	R:R:N166	6.98	5	2	7
21	R:R:Y167	7.43857	7	2	5
22	R:R:E180	5.1975	4	0	3
23	R:R:F184	5.39	4	1	6
24	R:R:L187	4.9125	4	1	5
25	R:R:Y191	6.548	5	0	7
26	R:R:Y195	5.18429	7	1	7
27	R:R:L202	4.6075	4	1	9
28	R:R:F212	7.362	5	7	7
29	R:R:L215	5.265	4	7	9
30	R:R:R219	5.305	4	6	9
31	R:R:H223	6.8275	4	6	9
32	R:R:F230	8.76667	6	1	8
33	R:R:R233	8.02429	7	1	8
34	R:R:I237	4.84	4	1	7
35	R:R:D241	5.94	4	0	8
36	R:R:F288	7.49	4	0	7
37	R:R:L289	6.408	5	1	7
38	R:R:Y290	6.356	5	1	9
39	R:R:F291	8.45	4	0	5
40	R:R:N295	11.725	4	1	8
41	R:R:Y296	9.07	6	1	7
42	R:R:Y297	6.736	5	1	6
43	R:R:W298	9.88714	7	1	9
44	R:R:I299	5.105	4	1	9
45	R:R:L300	5.9575	4	0	8
46	R:R:E302	11.08	4	0	9
47	R:R:Y305	8.8925	4	0	8
48	R:R:F311	9.4875	4	9	6
49	R:R:W329	9.865	4	1	9
50	R:R:L331	5.4325	4	1	4
51	R:R:P332	4.10333	6	1	9
52	R:R:F335	8.895	4	1	5
53	R:R:W339	6.44333	6	1	8
54	R:R:R343	9.2325	4	1	8
55	R:R:W352	11.44	5	1	8
56	R:R:D353	8.1725	4	0	5
57	R:R:K359	6.12	5	1	3
58	R:R:K360	7.3	5	1	7
59	R:R:W361	7.1575	4	1	8
60	R:R:Q364	8.828	5	1	7
61	R:R:F378	7.38833	6	3	9
62	R:R:F417	7.264	5	3	9
63	R:R:H420	10.5067	6	1	8
64	R:R:Y421	12.185	6	1	8
65	R:R:F424	6.658	5	1	7
66	R:R:M425	3.715	4	0	6
67	R:R:T427	5.4025	4	1	5
68	R:R:Y429	9.87	5	1	6
69	R:R:V432	7.845	4	1	5
70	R:R:W437	8.165	8	1	5
71	R:R:Q440	8.0125	4	1	6
72	R:R:M441	9.7075	4	1	6
73	R:R:Y443	7.794	5	1	4
74	R:R:N448	8.658	5	1	6
75	R:R:F450	6.135	4	1	7
76	R:R:Q451	6.966	5	1	9
77	R:R:F453	7.0625	4	0	6
78	R:R:Y459	9.0775	4	0	8
79	R:R:C460	4.2575	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:E4	R:R:R233	23.9719	3.49	Yes	Yes	1	0	8
2	R:R:R233	R:R:Y195	49.0751	6.17	Yes	Yes	1	8	7
3	L:L:E4	R:R:I237	26.8075	4.1	Yes	Yes	1	0	7
4	R:R:I237	R:R:Y195	28.0671	6.04	Yes	Yes	1	7	7
5	L:L:H5	L:L:L8	17.4148	3.86	Yes	No	1	0	0
6	L:L:H5	R:R:L289	17.988	11.57	Yes	Yes	1	0	7
7	L:L:L8	R:R:D353	21.0802	10.86	No	Yes	0	0	5
8	L:L:K11	R:R:Y245	11.5468	16.72	No	No	0	0	4
9	R:R:D353	R:R:Y245	82.3723	10.34	Yes	No	0	5	4
10	L:L:G12	R:R:D353	100	3.35	No	Yes	0	0	5
11	L:L:D17	L:L:K13	97.4781	5.53	No	No	0	0	0
12	L:L:K13	R:R:V31	97.8441	6.07	No	No	0	0	6
13	L:L:Q16	R:R:V31	98.2081	1.43	No	No	0	0	6
14	L:L:Q16	R:R:L354	99.289	11.98	No	No	0	0	5
15	L:L:G12	R:R:L354	99.6454	1.71	No	No	0	0	5
16	L:L:D17	L:L:R20	97.1102	8.34	No	Yes	0	0	0
17	L:L:R20	R:R:Q37	94.0987	5.84	Yes	No	0	0	7
18	R:R:I115	R:R:P132	32.9978	3.39	Yes	Yes	2	5	9
19	R:R:I135	R:R:P132	54.9298	5.08	Yes	Yes	2	7	9
20	R:R:I135	R:R:Q37	93.7138	8.23	Yes	No	0	7	7
21	R:R:F138	R:R:I115	33.3742	5.02	Yes	Yes	2	4	5
22	R:R:F138	R:R:I135	36.2298	18.84	Yes	Yes	2	4	7
23	R:R:I115	R:R:Y167	55.3528	13.3	Yes	Yes	2	5	5
24	L:L:H32	R:R:Y167	18.4557	9.8	No	Yes	2	0	5
25	L:L:H32	R:R:N166	16.1619	12.75	No	Yes	2	0	7
26	R:R:R146	R:R:Y167	35.1005	5.14	Yes	Yes	2	8	5
27	R:R:R146	R:R:W154	47.5627	8	Yes	Yes	2	8	9
28	R:R:L109	R:R:W154	37.5378	4.56	No	Yes	0	5	9
29	R:R:L109	R:R:P110	35.8514	3.28	No	No	0	5	6
30	R:R:L52	R:R:P110	18.8834	3.28	No	No	0	4	6
31	R:R:C48	R:R:L52	17.1762	3.17	Yes	No	0	8	4
32	R:R:L116	R:R:P132	21.5099	11.49	Yes	Yes	2	5	9
33	R:R:L116	R:R:W118	17.6752	4.56	Yes	Yes	2	5	9
34	R:R:R146	R:R:W118	17.2475	24.99	Yes	Yes	2	8	9
35	R:R:L120	R:R:P110	15.467	8.21	No	No	0	4	6
36	R:R:L120	R:R:P107	13.756	4.93	No	No	0	4	3
37	R:R:Y191	R:R:Y195	26.6783	3.97	Yes	Yes	0	7	7
38	R:R:D241	R:R:I237	53.7339	4.2	Yes	Yes	0	8	7
39	R:R:D241	R:R:Y191	27.2486	9.2	Yes	Yes	0	8	7
40	R:R:N295	R:R:R233	72.7904	15.67	Yes	Yes	1	8	8
41	R:R:F230	R:R:N295	32.4493	18.12	Yes	Yes	1	8	8
42	R:R:F230	R:R:L226	29.1802	7.31	Yes	No	0	8	9
43	R:R:E302	R:R:L226	28.4777	15.9	Yes	No	0	9	9
44	R:R:E302	R:R:H223	25.5718	12.31	Yes	Yes	0	9	9
45	R:R:H223	R:R:R219	13.8643	7.9	Yes	Yes	6	9	9
46	R:R:E465	R:R:R219	12.1485	3.49	No	Yes	0	9	9
47	R:R:N295	R:R:S229	17.6515	7.45	Yes	No	0	8	9
48	R:R:S229	R:R:W298	16.9043	7.41	No	Yes	0	9	9
49	R:R:I222	R:R:W298	16.371	3.52	No	Yes	0	9	9
50	R:R:I222	R:R:Y305	14.6761	9.67	No	Yes	0	9	8
51	R:R:I299	R:R:N295	23.5613	5.66	Yes	Yes	1	9	8
52	R:R:I299	R:R:N374	27.4625	4.25	Yes	No	0	9	9
53	R:R:F417	R:R:N374	27.3123	7.25	Yes	No	0	9	9
54	R:R:F335	R:R:I363	12.0706	6.28	Yes	No	1	5	7
55	R:R:F378	R:R:F417	15.7845	9.65	Yes	Yes	3	9	9
56	R:R:F378	R:R:V382	11.2445	7.87	Yes	No	3	9	7
57	R:R:L406	R:R:V382	10.4023	1.49	No	No	0	8	7
58	R:R:I458	R:R:Y459	12.621	7.25	No	Yes	0	8	8
59	R:R:D241	R:R:Y245	82.7145	3.45	Yes	No	0	8	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:V2	R:R:Y296	3.79	0	No	Yes	0	7	0	1
L:L:V2	R:R:Q364	10.03	0	No	Yes	0	7	0	1
L:L:S3	R:R:E444	11.5	0	No	No	0	7	0	1
L:L:E4	R:R:Y195	7.86	1	Yes	Yes	0	7	0	1
L:L:E4	R:R:R233	3.49	1	Yes	Yes	0	8	0	1
L:L:E4	R:R:I237	4.1	1	Yes	Yes	0	7	0	1
L:L:E4	R:R:M445	6.77	1	Yes	No	0	6	0	1
L:L:E4	R:R:N448	3.94	1	Yes	Yes	0	6	0	1
L:L:H5	R:R:L289	11.57	1	Yes	Yes	0	7	0	1
L:L:H5	R:R:Q364	11.13	1	Yes	Yes	0	7	0	1
L:L:Q6	R:R:Y429	12.4	1	Yes	Yes	0	6	0	1
L:L:Q6	R:R:W437	4.38	1	Yes	Yes	0	5	0	1
L:L:Q6	R:R:Q440	6.4	1	Yes	Yes	0	6	0	1
L:L:Q6	R:R:M441	6.8	1	Yes	Yes	0	6	0	1
L:L:L7	R:R:L187	4.15	0	No	Yes	0	5	0	1
L:L:L8	R:R:D353	10.86	1	No	Yes	0	5	0	1
L:L:H9	R:R:S355	9.76	1	Yes	No	0	7	0	1
L:L:H9	R:R:K360	6.55	1	Yes	Yes	0	7	0	1
L:L:H9	R:R:Y429	9.8	1	Yes	Yes	0	6	0	1
L:L:D10	R:R:V432	5.84	1	No	Yes	0	5	0	1
L:L:D10	R:R:W437	8.93	1	No	Yes	0	5	0	1
L:L:K11	R:R:F184	3.72	0	No	Yes	0	6	0	1
L:L:K11	R:R:Y245	16.72	0	No	No	0	4	0	1
L:L:G12	R:R:D353	3.35	0	No	Yes	0	5	0	1
L:L:K13	R:R:V31	6.07	0	No	No	0	6	0	1
L:L:S14	R:R:F184	5.28	0	No	Yes	0	6	0	1
L:L:I15	R:R:R181	6.26	0	No	No	0	3	0	1
L:L:Q16	R:R:T33	7.09	0	No	No	0	7	0	1
L:L:Q16	R:R:L354	11.98	0	No	No	0	5	0	1
L:L:R20	R:R:Q37	5.84	4	Yes	No	0	7	0	1
L:L:R20	R:R:Y136	6.17	4	Yes	No	0	4	0	1
L:L:R20	R:R:D137	11.91	4	Yes	No	0	5	0	1
L:L:R21	R:R:D137	7.15	0	No	No	0	5	0	1
L:L:F23	R:R:K34	7.44	2	No	No	0	4	0	1
L:L:F23	R:R:I38	6.28	2	No	No	0	7	0	1
L:L:L24	R:R:I135	5.71	2	No	Yes	0	7	0	1
L:L:L24	R:R:F138	6.09	2	No	Yes	0	4	0	1
L:L:I28	R:R:F138	6.28	2	No	Yes	0	4	0	1
L:L:I31	R:R:D113	12.59	2	Yes	No	0	9	0	1
L:L:I31	R:R:I115	5.89	2	Yes	Yes	0	5	0	1
L:L:I31	R:R:Y167	9.67	2	Yes	Yes	0	5	0	1
L:L:H32	R:R:N166	12.75	2	No	Yes	0	7	0	1
L:L:H32	R:R:Y167	9.8	2	No	Yes	0	5	0	1
L:L:H32	R:R:S168	5.58	2	No	No	0	6	0	1
R:R:M32	R:R:Y136	3.59	0	No	No	6	4	2	1
R:R:E35	R:R:T33	7.06	0	No	No	5	7	2	1
R:R:I38	R:R:K34	5.82	2	No	No	7	4	1	1
R:R:I135	R:R:Q37	8.23	2	Yes	No	7	7	1	1
R:R:D113	R:R:R146	7.15	0	No	Yes	9	8	1	2
R:R:I115	R:R:L116	4.28	2	Yes	Yes	5	5	1	2
R:R:I115	R:R:P132	3.39	2	Yes	Yes	5	9	1	2
R:R:F138	R:R:I115	5.02	2	Yes	Yes	4	5	1	1
R:R:I115	R:R:Y167	13.3	2	Yes	Yes	5	5	1	1
R:R:L116	R:R:W118	4.56	2	Yes	Yes	5	9	2	2
R:R:L116	R:R:P132	11.49	2	Yes	Yes	5	9	2	2
R:R:R146	R:R:W118	24.99	2	Yes	Yes	8	9	2	2
R:R:W118	R:R:Y167	4.82	2	Yes	Yes	9	5	2	1
R:R:I135	R:R:P132	5.08	2	Yes	Yes	7	9	1	2
R:R:F138	R:R:P132	7.22	2	Yes	Yes	4	9	1	2
R:R:F138	R:R:I135	18.84	2	Yes	Yes	4	7	1	1
R:R:D137	R:R:Y136	5.75	4	No	No	5	4	1	1
R:R:C170	R:R:F138	11.17	0	No	Yes	9	4	2	1
R:R:A144	R:R:Y167	4	0	No	Yes	7	5	2	1
R:R:N166	R:R:Y145	8.14	2	Yes	Yes	7	4	1	2
R:R:E169	R:R:Y145	12.35	2	No	Yes	5	4	2	2
R:R:A165	R:R:R146	4.15	2	No	Yes	7	8	2	2
R:R:R146	R:R:Y167	5.14	2	Yes	Yes	8	5	2	1
R:R:A165	R:R:Y167	5.34	2	No	Yes	7	5	2	1
R:R:N166	R:R:S168	8.94	2	Yes	No	7	6	1	1
R:R:E169	R:R:N166	3.94	2	No	Yes	5	7	2	1
R:R:L174	R:R:V171	5.96	0	No	No	3	3	2	1
R:R:E180	R:R:V432	4.28	0	Yes	Yes	3	5	2	1
R:R:D185	R:R:R181	5.96	0	No	No	2	3	2	1
R:R:F184	R:R:V432	6.55	1	Yes	Yes	6	5	1	1
R:R:F184	R:R:W437	6.01	1	Yes	Yes	6	5	1	1
R:R:L187	R:R:W437	3.42	1	Yes	Yes	5	5	1	1
R:R:L187	R:R:M441	5.65	1	Yes	Yes	5	6	1	1
R:R:H442	R:R:L187	6.43	0	No	Yes	5	5	2	1
R:R:I190	R:R:M445	4.37	0	No	No	6	6	2	1
R:R:Y191	R:R:Y195	3.97	0	Yes	Yes	7	7	2	1
R:R:D241	R:R:Y191	9.2	0	Yes	Yes	8	7	2	2
R:R:M445	R:R:Y191	8.38	0	No	Yes	6	7	1	2
R:R:R233	R:R:Y195	6.17	1	Yes	Yes	8	7	1	1
R:R:A234	R:R:Y195	5.34	0	No	Yes	8	7	2	1
R:R:I237	R:R:Y195	6.04	1	Yes	Yes	7	7	1	1
R:R:S449	R:R:Y195	3.82	1	No	Yes	9	7	2	1
R:R:L292	R:R:R233	9.72	1	No	Yes	6	8	2	1
R:R:N295	R:R:R233	15.67	1	Yes	Yes	8	8	2	1
R:R:R233	R:R:Y296	13.38	1	Yes	Yes	8	7	1	1
R:R:R233	R:R:Y421	4.12	1	Yes	Yes	8	8	1	2
R:R:N448	R:R:R233	3.62	1	Yes	Yes	6	8	1	1
R:R:D241	R:R:I237	4.2	0	Yes	Yes	8	7	2	1
R:R:F288	R:R:I237	5.02	0	Yes	Yes	7	7	2	1
R:R:D241	R:R:Y245	3.45	0	Yes	No	8	4	2	1
R:R:D353	R:R:L244	8.14	0	Yes	No	5	5	1	2
R:R:D353	R:R:Y245	10.34	0	Yes	No	5	4	1	1
R:R:F288	R:R:L289	6.09	0	Yes	Yes	7	7	2	1
R:R:L289	R:R:W339	5.69	1	Yes	Yes	7	8	1	2
R:R:I363	R:R:L289	5.71	1	No	Yes	7	7	2	1
R:R:L292	R:R:Y296	5.86	1	No	Yes	6	7	2	1
R:R:I367	R:R:Y296	9.67	0	No	Yes	7	7	2	1
R:R:I371	R:R:Y296	4.84	1	No	Yes	7	7	2	1
R:R:Y296	R:R:Y421	16.88	1	Yes	Yes	7	8	1	2
R:R:I363	R:R:W339	14.09	1	No	Yes	7	8	2	2
R:R:K360	R:R:S355	4.59	1	Yes	No	7	7	1	1
R:R:K360	R:R:W361	6.96	1	Yes	Yes	7	8	1	2
R:R:K360	R:R:Q364	4.07	1	Yes	Yes	7	7	1	1
R:R:K360	R:R:Y429	14.33	1	Yes	Yes	7	6	1	1
R:R:Q364	R:R:W361	8.76	1	Yes	Yes	7	8	1	2
R:R:Q364	R:R:Y429	10.15	1	Yes	Yes	7	6	1	1
R:R:I371	R:R:Y421	7.25	1	No	Yes	7	8	2	2
R:R:H420	R:R:Y421	20.69	1	Yes	Yes	8	8	2	2
R:R:H420	R:R:Y443	3.27	1	Yes	Yes	8	4	2	2
R:R:H420	R:R:N448	8.93	1	Yes	Yes	8	6	2	1
R:R:N448	R:R:Y421	16.28	1	Yes	Yes	6	8	1	2
R:R:F424	R:R:T427	5.19	1	Yes	Yes	7	5	2	2
R:R:F424	R:R:Q440	11.71	1	Yes	Yes	7	6	2	1
R:R:F424	R:R:Y443	7.22	1	Yes	Yes	7	4	2	2
R:R:Q440	R:R:T427	8.5	1	Yes	Yes	6	5	1	2
R:R:T430	R:R:W437	3.64	0	No	Yes	5	5	2	1
R:R:V432	R:R:W437	14.71	1	Yes	Yes	5	5	1	1
R:R:Q438	R:R:W437	3.29	0	No	Yes	4	5	2	1
R:R:M441	R:R:W437	20.94	1	Yes	Yes	6	5	1	1
R:R:M441	R:R:Q440	5.44	1	Yes	Yes	6	6	1	1
R:R:E444	R:R:Y443	3.37	0	No	Yes	7	4	1	2
R:R:E444	R:R:N448	10.52	0	No	Yes	7	6	1	1
R:R:F238	R:R:Y195	3.09	0	No	Yes	7	7	2	1
L:L:I28	R:R:V171	3.07	2	No	No	0	3	0	1
L:L:V2	R:R:L368	2.98	0	No	No	0	4	0	1
R:R:L289	R:R:V285	2.98	1	Yes	No	7	6	1	2
L:L:A1	R:R:Y429	2.67	0	No	Yes	0	6	0	1
R:R:H42	R:R:I38	2.65	0	No	No	4	7	2	1
L:L:L18	R:R:R181	2.43	0	No	No	0	3	0	1
R:R:G357	R:R:S355	1.86	0	No	No	6	7	2	1
L:L:G12	R:R:L354	1.71	0	No	No	0	5	0	1
L:L:Q16	R:R:V31	1.43	0	No	No	0	6	0	1
R:R:N166	R:R:W164	1.13	2	Yes	Yes	7	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8FLR_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.17
Number of Linked Nodes	368
Number of Links	453
Number of Hubs	79
Number of Links mediated by Hubs	280
Number of Communities	9
Number of Nodes involved in Communities	115
Number of Links involved in Communities	172

Path Summary
Number Of Nodes in MetaPath	60
Number Of Links MetaPath	59
Number of Shortest Paths	174364
Length Of Smallest Path	3
Average Path Length	20.0158
Length of Longest Path	40
Minimum Path Strength	1.525
Average Path Strength	7.09457
Maximum Path Strength	21.99
Minimum Path Correlation	0.7
Average Path Correlation	0.957079
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	60.8313
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	52.5027
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• identical protein binding • protein binding • binding • protein homodimerization activity • protein dimerization activity • amide binding • peptide hormone binding • hormone binding • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • parathyroid hormone receptor activity • developmental process • multicellular organismal process • ossification • bone mineralization • animal organ development • anatomical structure development • biomineral tissue development • tissue development • multicellular organism development • skeletal system development • system development • cell population proliferation • cellular process • cellular response to stimulus
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • ossification • bone mineralization • animal organ development • anatomical structure development • biomineral tissue development • tissue development • multicellular organism development • skeletal system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • osteoblast development • cellular developmental process • cell differentiation • cell development • osteoblast differentiation • embryo development ending in birth or egg hatching • chordate embryonic development • embryo development • in utero embryonic development • anatomical structure maturation • cell maturation • developmental maturation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • cell surface receptor signaling pathway • negative regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • phospholipase C-activating G protein-coupled receptor signaling pathway • connective tissue development • chondrocyte differentiation • cartilage development • regulation of inositol phosphate biosynthetic process • alcohol metabolic process • positive regulation of phosphate metabolic process • inositol phosphate metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • phosphate-containing compound metabolic process • polyol biosynthetic process • small molecule metabolic process • phosphorus metabolic process • regulation of carbohydrate metabolic process • regulation of biosynthetic process • carbohydrate metabolic process • polyol metabolic process • positive regulation of phosphorus metabolic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • carbohydrate biosynthetic process • primary metabolic process • positive regulation of inositol phosphate biosynthetic process • biosynthetic process • organophosphate metabolic process • organophosphate biosynthetic process • inositol phosphate biosynthetic process • alcohol biosynthetic process • metabolic process • regulation of phosphorus metabolic process • positive regulation of carbohydrate metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • tissue homeostasis • bone resorption • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • cellular anatomical structure • organelle lumen • organelle • membraneless organelle • nuclear lumen
Gene Ontology	Cellular Component	• membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • cellular anatomical structure • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • apical part of cell • membrane • plasma membrane • plasma membrane region • apical plasma membrane • cytoplasm • cytosol • basal part of cell • basal plasma membrane • basolateral plasma membrane • protein-containing complex • receptor complex • hormone activity • protein binding • binding • molecular function activator activity • signaling receptor binding • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • peptide hormone receptor binding • hormone receptor binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • developmental process • multicellular organismal process • ossification • bone mineralization • animal organ development • anatomical structure development • biomineral tissue development • tissue development • multi-multicellular organism process • reproductive process • female pregnancy • multi-organism reproductive process • negative regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • multicellular organism development • skeletal system development • system development • regulation of chondrocyte differentiation • regulation of cartilage development • regulation of developmental process • cellular developmental process • connective tissue development • negative regulation of cartilage development • cell development • regulation of cell differentiation • negative regulation of chondrocyte differentiation • negative regulation of chondrocyte development • regulation of cell development • regulation of chondrocyte development • cell differentiation • negative regulation of cell differentiation • regulation of multicellular organismal process • regulation of multicellular organismal development • negative regulation of developmental process • negative regulation of cell development • chondrocyte differentiation • negative regulation of multicellular organismal process • chondrocyte development • cartilage development • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • regulation of metabolic process • epidermis development • cell-cell signaling • nucleoside phosphate metabolic process • ribose phosphate metabolic process • cAMP metabolic process • cyclic purine nucleotide metabolic process • carbohydrate derivative metabolic process • primary metabolic process • nucleotide metabolic process • cyclic nucleotide metabolic process • purine-containing compound metabolic process • nucleobase-containing compound metabolic process • purine nucleotide metabolic process • ribonucleotide metabolic process • organophosphate metabolic process • nucleobase-containing small molecule metabolic process • phosphate-containing compound metabolic process • small molecule metabolic process • purine ribonucleotide metabolic process • phosphorus metabolic process • osteoblast development • osteoblast differentiation • Golgi apparatus • endomembrane system • extracellular region • extracellular space • nucleoplasm • G-protein beta-subunit binding • fibroblast proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • molting cycle process • hair cycle • hair follicle placode formation • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • homeostatic process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q03431
Sequence	>8FLR_nogp_Chain_R V M T K E E Q I F L L H R A Q A Q C E K R L K E G R P C L P E W D H I L C W P L G A P G E V V A V P C P D Y I Y D F N H K G H A Y R R C D R N G S W E L V P G H N R T W A N Y S E C V K F L T N E T R E R E V F D R L G M I Y T V G Y S V S L A S L T V A V L I L A Y F R R L H C T R N Y I H M H L F L S F M L R A V S I F V K D A V L Y S G Y A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M A F F S E K K Y L W G F T V F G W G L P A V F V A V W V S V R A T L A N T G C W D L S S G N K K W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L R E T T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M A T P Y T E V S G T L W Q V Q M H Y E M L F N S F Q G F F V A I I Y C F C N G E V Q A E I K K S W S R W T L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8GW8	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371	Gs/β1/γ2	2.9	2023-06-14	doi.org/10.1038/s41586-023-06169-3
	8GW8 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371		2.9	2023-06-14	doi.org/10.1038/s41586-023-06169-3
	8JR9	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371	chim(NtGi1-Gs)/β1/γ2	2.57	2023-08-02	doi.org/10.1038/s41586-023-06467-w
	8JR9 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371		2.57	2023-08-02	doi.org/10.1038/s41586-023-06467-w
	7VVJ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVJ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVK	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.3	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVK (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.3	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVL	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVL (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVM	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVM (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVN	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVN (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	4.1	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		4.1	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	8FLQ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.55	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLQ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.55	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLR	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	2.94	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLR (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		2.94	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLS	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	3.09	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLS (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		3.09	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLT	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-	Gs/β1/γ2	3.03	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLT (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-		3.03	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLU	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-	Gs/β1/γ2	2.76	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLU (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-		2.76	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8HA0	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	2.62	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HA0 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.62	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	chim(NtGi1-Gs)/β1/γ2	3.25	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.25	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	3.76	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.76	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	6FJ3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	-	2.5	2018-11-21	doi.org/10.1038/s41594-018-0151-4
	6NBF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	3	2019-04-17	doi.org/10.1126/science.aav7942
	6NBF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		3	2019-04-17	doi.org/10.1126/science.aav7942
	6NBH	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	3.5	2019-04-17	doi.org/10.1126/science.aav7942
	6NBH (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		3.5	2019-04-17	doi.org/10.1126/science.aav7942
	6NBI	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	4	2019-04-17	doi.org/10.1126/science.aav7942
	6NBI (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		4	2019-04-17	doi.org/10.1126/science.aav7942
	9B5Y	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-	chim(NtGi1-Gq)/β1/γ2	3.49	2025-03-19	doi.org/10.1073/pnas.2426178122
	9B5Y (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-		3.49	2025-03-19	doi.org/10.1073/pnas.2426178122
	7Y35	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	2.9	2023-07-05	To be published
	7Y35 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		2.9	2023-07-05	To be published
	7Y36	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Teriparatide	-	Gs/β1/γ2	2.8	2023-07-05	To be published
	7Y36 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Teriparatide	-		2.8	2023-07-05	To be published
	9JR2	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	To be published
	9JR2 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	To be published
	9JR3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	To be published
	9JR3 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	To be published

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