psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:I5	L:L:V2	6.14	No	No	5	0	0
2	L:L:V2	R:R:Q364	10.03	No	No	5	0	7
3	L:L:V2	R:R:I367	4.61	No	No	0	0	7
4	L:L:S3	R:R:E444	14.37	No	Yes	0	0	7
5	L:L:E4	R:R:I237	6.83	No	Yes	3	0	7
6	L:L:E4	R:R:F288	8.16	No	Yes	3	0	7
7	L:L:E4	R:R:M445	4.06	No	No	0	0	6
8	L:L:I5	R:R:Q364	15.1	No	No	5	0	7
9	L:L:N10	L:L:Q6	6.6	No	No	0	0	0
10	L:L:Q6	R:R:T430	8.5	No	No	0	0	5
11	L:L:L11	L:L:L7	8.3	No	No	0	0	0
12	L:L:L7	R:R:W437	6.83	No	Yes	0	0	5
13	L:L:M8	R:R:K240	8.64	No	No	3	0	7
14	L:L:M8	R:R:F288	3.73	No	Yes	3	0	7
15	L:L:L11	R:R:F184	12.18	No	No	0	0	6
16	L:L:H14	L:L:S17	9.76	No	No	0	0	0
17	L:L:H14	R:R:R181	10.16	No	No	0	0	3
18	L:L:E19	R:R:K34	21.6	No	No	0	0	4
19	L:L:R20	R:R:Q37	15.19	No	No	0	0	7
20	L:L:W23	R:R:K34	12.76	No	No	0	0	4
21	L:L:L24	R:R:L174	4.15	No	No	6	0	3
22	L:L:K26	L:L:Q29	10.85	No	No	0	0	0
23	L:L:K27	R:R:I115	4.36	No	No	0	0	5
24	L:L:D30	L:L:V31	4.38	No	No	0	0	0
25	L:L:V31	R:R:Y167	6.31	No	No	0	0	5
26	L:L:F34	R:R:R162	5.34	No	No	0	0	3
27	R:R:E35	R:R:T33	4.23	No	No	0	5	7
28	R:R:E36	R:R:T33	5.64	No	No	0	6	7
29	R:R:L40	R:R:Y134	8.21	No	No	0	5	5
30	R:R:L41	R:R:Q45	3.99	No	No	0	8	7
31	R:R:C48	R:R:W112	9.14	No	No	0	8	7
32	R:R:C117	R:R:C48	7.28	No	No	0	9	8
33	R:R:L116	R:R:P132	14.78	No	No	0	5	9
34	R:R:H143	R:R:P130	4.58	No	No	0	3	5
35	R:R:C131	R:R:P132	5.65	No	No	0	9	9
36	R:R:C131	R:R:F138	11.17	No	Yes	0	9	4
37	R:R:C131	R:R:C170	7.28	No	No	0	9	9
38	R:R:I135	R:R:P132	5.08	No	No	0	7	9
39	R:R:D133	R:R:F138	4.78	No	Yes	7	2	4
40	R:R:D133	R:R:H140	8.82	No	No	7	2	3
41	R:R:F138	R:R:I135	8.79	Yes	No	0	4	7
42	R:R:F138	R:R:H140	19.23	Yes	No	7	4	3
43	R:R:G142	R:R:N139	5.09	No	No	0	5	4
44	R:R:N166	R:R:W164	12.43	No	No	0	7	5
45	R:R:V171	R:R:Y167	5.05	No	No	0	3	5
46	R:R:L174	R:R:V171	7.45	No	No	0	3	3
47	R:R:D185	R:R:E182	6.5	No	No	0	2	2
48	R:R:E182	R:R:R186	9.3	No	No	0	2	5
49	R:R:M441	R:R:V183	4.56	No	No	0	6	4
50	R:R:F184	R:R:W437	6.01	No	Yes	0	6	5
51	R:R:L187	R:R:M441	9.9	No	No	0	5	6
52	R:R:G188	R:R:Y191	5.79	No	No	0	5	7
53	R:R:T192	R:R:Y191	3.75	No	No	0	7	7
54	R:R:Y191	R:R:Y195	4.96	No	Yes	0	7	7
55	R:R:G194	R:R:S449	3.71	No	No	0	9	9
56	R:R:F450	R:R:G194	9.03	No	No	0	7	9
57	R:R:R233	R:R:Y195	12.35	Yes	Yes	0	8	7
58	R:R:A234	R:R:Y195	4	No	Yes	0	8	7
59	R:R:I237	R:R:Y195	14.51	Yes	Yes	0	7	7
60	R:R:S449	R:R:Y195	11.45	No	Yes	0	9	7
61	R:R:F453	R:R:V197	5.24	No	No	0	6	5
62	R:R:G452	R:R:S198	3.71	No	No	0	9	9
63	R:R:L202	R:R:S201	4.5	Yes	No	0	9	8
64	R:R:F227	R:R:L202	6.09	No	Yes	0	9	9
65	R:R:F230	R:R:L202	4.87	Yes	Yes	0	8	9
66	R:R:L202	R:R:M231	4.24	Yes	No	0	9	8
67	R:R:M231	R:R:T203	4.52	No	No	0	8	3
68	R:R:F461	R:R:V204	3.93	No	No	0	8	5
69	R:R:F227	R:R:V206	3.93	No	No	0	9	5
70	R:R:L209	R:R:N220	9.61	No	No	0	7	9
71	R:R:N220	R:R:R214	10.85	No	Yes	0	9	7
72	R:R:N463	R:R:R214	4.82	No	Yes	8	9	7
73	R:R:E465	R:R:R214	8.14	No	Yes	0	9	7
74	R:R:R214	R:R:V466	18.31	Yes	No	8	7	9
75	R:R:H216	R:R:R219	4.51	No	Yes	0	8	9
76	R:R:C217	R:R:K318	8.08	No	No	0	8	5
77	R:R:R219	R:R:T218	6.47	Yes	No	0	9	7
78	R:R:E317	R:R:T218	5.64	Yes	No	0	6	7
79	R:R:N220	R:R:R219	7.23	No	Yes	0	9	9
80	R:R:E465	R:R:R219	10.47	No	Yes	0	9	9
81	R:R:E302	R:R:I222	4.1	No	No	0	9	9
82	R:R:E302	R:R:H223	9.85	No	No	0	9	9
83	R:R:H223	R:R:Y459	6.53	No	No	0	9	8
84	R:R:H225	R:R:W298	15.87	No	Yes	0	8	9
85	R:R:C460	R:R:F227	4.19	Yes	No	0	9	9
86	R:R:L228	R:R:W329	4.56	No	Yes	0	4	9
87	R:R:S229	R:R:T294	4.8	Yes	Yes	2	9	8
88	R:R:N295	R:R:S229	8.94	No	Yes	0	8	9
89	R:R:S229	R:R:W298	6.18	Yes	Yes	2	9	9
90	R:R:S229	R:R:W329	3.71	Yes	Yes	2	9	9
91	R:R:F230	R:R:N295	10.87	Yes	No	0	8	8
92	R:R:F230	R:R:Q451	9.37	Yes	Yes	0	8	9
93	R:R:F230	R:R:V455	3.93	Yes	No	0	8	9
94	R:R:F291	R:R:L232	15.83	No	No	0	5	8
95	R:R:L292	R:R:R233	7.29	No	Yes	1	6	8
96	R:R:N295	R:R:R233	15.67	No	Yes	0	8	8
97	R:R:R233	R:R:Y296	5.14	Yes	Yes	1	8	7
98	R:R:F288	R:R:S236	7.93	Yes	No	0	7	7
99	R:R:F288	R:R:I237	3.77	Yes	Yes	3	7	7
100	R:R:F288	R:R:K240	8.69	Yes	No	3	7	7
101	R:R:L244	R:R:V243	4.47	No	Yes	0	5	5
102	R:R:A284	R:R:V243	5.09	No	Yes	0	6	5
103	R:R:C281	R:R:C351	7.28	No	No	0	9	9
104	R:R:R282	R:R:R343	6.4	No	Yes	0	8	8
105	R:R:N348	R:R:R282	8.44	No	No	0	7	8
106	R:R:F287	R:R:V283	7.87	No	No	0	3	4
107	R:R:V285	R:R:W339	3.68	No	Yes	0	6	8
108	R:R:R343	R:R:T286	9.06	Yes	No	0	8	7
109	R:R:L289	R:R:W339	9.11	No	Yes	0	7	8
110	R:R:I363	R:R:L289	11.42	No	No	0	7	7
111	R:R:F291	R:R:Y290	7.22	No	Yes	0	5	9
112	R:R:T294	R:R:Y290	6.24	Yes	Yes	2	8	9
113	R:R:P332	R:R:Y290	4.17	Yes	Yes	2	9	9
114	R:R:A333	R:R:Y290	5.34	No	Yes	0	5	9
115	R:R:V336	R:R:Y290	5.05	No	Yes	0	7	9
116	R:R:L292	R:R:Y296	5.86	No	Yes	1	6	7
117	R:R:T294	R:R:W329	8.49	Yes	Yes	2	8	9
118	R:R:P332	R:R:T294	5.25	Yes	Yes	2	9	8
119	R:R:I367	R:R:Y296	12.09	No	Yes	0	7	7
120	R:R:Y296	R:R:Y421	16.88	Yes	Yes	1	7	8
121	R:R:F327	R:R:Y297	6.19	No	Yes	0	5	6
122	R:R:L331	R:R:Y297	5.86	No	Yes	0	4	6
123	R:R:P366	R:R:Y297	4.17	No	Yes	0	9	6
124	R:R:S370	R:R:Y297	6.36	No	Yes	0	7	6
125	R:R:V301	R:R:W298	4.9	No	Yes	0	8	9
126	R:R:T325	R:R:W298	4.85	No	Yes	0	5	9
127	R:R:G328	R:R:W298	8.44	No	Yes	0	9	9
128	R:R:W298	R:R:W329	23.43	Yes	Yes	2	9	9
129	R:R:I299	R:R:N374	4.25	No	No	0	9	9
130	R:R:I299	R:R:Q451	5.49	No	Yes	0	9	9
131	R:R:L300	R:R:S370	7.51	No	No	0	8	7
132	R:R:L300	R:R:N374	4.12	No	No	0	8	9
133	R:R:E302	R:R:L416	11.93	No	No	0	9	9
134	R:R:F417	R:R:G303	9.03	Yes	No	0	9	9
135	R:R:L309	R:R:Y305	8.21	No	No	9	8	8
136	R:R:E317	R:R:Y305	7.86	Yes	No	9	6	8
137	R:R:F311	R:R:H307	16.97	Yes	No	0	6	8
138	R:R:H307	R:R:L377	15.43	No	No	0	8	7
139	R:R:H307	R:R:N380	7.65	No	No	0	8	8
140	R:R:E317	R:R:L309	6.63	Yes	No	9	6	8
141	R:R:F311	R:R:I310	3.77	Yes	No	10	6	8
142	R:R:I310	R:R:V384	4.61	No	No	10	8	8
143	R:R:F311	R:R:R383	4.28	Yes	No	0	6	8
144	R:R:F311	R:R:V384	3.93	Yes	No	10	6	8
145	R:R:F315	R:R:M312	4.98	No	No	0	6	5
146	R:R:K319	R:R:Y320	10.75	No	No	0	6	4
147	R:R:L321	R:R:T325	4.42	Yes	No	0	6	5
148	R:R:F335	R:R:I362	6.28	No	No	0	5	8
149	R:R:F335	R:R:P366	13	No	No	0	5	9
150	R:R:I363	R:R:V336	4.61	No	No	0	7	7
151	R:R:V342	R:R:W339	8.58	No	Yes	0	5	8
152	R:R:R343	R:R:W339	9	Yes	Yes	0	8	8
153	R:R:I362	R:R:W339	5.87	No	Yes	0	8	8
154	R:R:R343	R:R:V340	19.61	Yes	No	0	8	5
155	R:R:R343	R:R:W352	4	Yes	Yes	0	8	8
156	R:R:L346	R:R:W352	12.53	No	Yes	0	3	8
157	R:R:N348	R:R:W352	12.43	No	Yes	0	7	8
158	R:R:C351	R:R:W352	3.92	No	Yes	0	9	8
159	R:R:V365	R:R:W361	3.68	No	No	0	5	8
160	R:R:L368	R:R:M425	12.72	No	No	0	4	6
161	R:R:I371	R:R:Y421	7.25	No	Yes	0	7	8
162	R:R:I371	R:R:M425	7.29	No	No	0	7	6
163	R:R:F417	R:R:N374	6.04	Yes	No	0	9	9
164	R:R:F375	R:R:I379	3.77	No	No	0	7	5
165	R:R:F375	R:R:V419	5.24	No	No	0	7	7
166	R:R:F375	R:R:I422	16.33	No	No	0	7	5
167	R:R:I376	R:R:I379	4.42	No	No	0	4	5
168	R:R:F378	R:R:V382	6.55	Yes	No	0	9	7
169	R:R:F378	R:R:L413	4.87	Yes	No	4	9	9
170	R:R:F378	R:R:F417	11.79	Yes	Yes	4	9	9
171	R:R:F378	R:R:V419	6.55	Yes	No	0	9	7
172	R:R:I379	R:R:N380	5.66	No	No	0	5	8
173	R:R:N380	R:R:R383	7.23	No	No	0	8	8
174	R:R:I381	R:R:L413	5.71	No	No	4	9	9
175	R:R:F417	R:R:I381	8.79	Yes	No	4	9	9
176	R:R:T410	R:R:V382	7.93	No	No	0	9	7
177	R:R:K388	R:R:V384	4.55	No	No	0	9	8
178	R:R:K388	R:R:T387	6.01	No	No	0	9	7
179	R:R:R390	R:R:T387	5.17	No	No	0	6	7
180	R:R:L389	R:R:Q402	3.99	Yes	No	0	8	6
181	R:R:K405	R:R:L389	7.05	No	Yes	0	8	8
182	R:R:L389	R:R:L406	4.15	Yes	No	0	8	8
183	R:R:Q401	R:R:R404	5.84	No	No	0	6	6
184	R:R:K408	R:R:R404	3.71	No	No	0	8	6
185	R:R:F417	R:R:L413	6.09	Yes	No	4	9	9
186	R:R:M414	R:R:P415	5.03	No	No	0	8	9
187	R:R:M414	R:R:V419	4.56	No	No	0	8	7
188	R:R:F454	R:R:P415	5.78	No	No	0	6	9
189	R:R:I458	R:R:P415	5.08	No	No	0	8	9
190	R:R:L416	R:R:Y459	16.41	No	No	0	9	8
191	R:R:F447	R:R:H420	4.53	No	No	0	5	8
192	R:R:H420	R:R:Q451	8.65	No	Yes	0	8	9
193	R:R:F454	R:R:H420	4.53	No	No	0	6	8
194	R:R:E444	R:R:Y421	5.61	Yes	Yes	1	7	8
195	R:R:N448	R:R:Y421	13.96	No	Yes	1	6	8
196	R:R:Q451	R:R:Y421	6.76	Yes	Yes	0	9	8
197	R:R:F424	R:R:V423	6.55	Yes	No	0	7	6
198	R:R:F424	R:R:T427	3.89	Yes	No	1	7	5
199	R:R:F424	R:R:Q440	11.71	Yes	No	1	7	6
200	R:R:F424	R:R:Y443	7.22	Yes	No	0	7	4
201	R:R:E444	R:R:F424	5.83	Yes	Yes	1	7	7
202	R:R:T427	R:R:Y429	4.99	No	No	0	5	6
203	R:R:Q440	R:R:T427	8.5	No	No	1	6	5
204	R:R:L436	R:R:Y429	15.24	No	No	0	4	6
205	R:R:T430	R:R:W437	12.13	No	Yes	0	5	5
206	R:R:Q440	R:R:T430	5.67	No	No	0	6	5
207	R:R:M441	R:R:W437	27.92	No	Yes	0	6	5
208	R:R:F447	R:R:Y443	11.35	No	No	0	5	4
209	R:R:E444	R:R:N448	13.15	Yes	No	1	7	6
210	R:R:F447	R:R:L446	6.09	No	No	0	5	5
211	R:R:I458	R:R:Y459	13.3	No	No	0	8	8
212	R:R:N463	R:R:V466	4.43	No	No	8	9	9
213	R:R:E469	R:R:S473	10.06	No	No	0	9	4
214	R:R:K472	R:R:R476	9.9	No	No	0	7	7
215	R:R:F315	R:R:L309	3.65	No	No	0	6	8
216	R:R:A205	R:R:C460	3.61	No	Yes	0	9	9
217	R:R:P130	R:R:V129	3.53	No	No	0	5	5
218	R:R:P366	R:R:V365	3.53	No	No	0	9	5
219	R:R:E35	R:R:F39	3.5	No	No	0	5	7
220	R:R:E391	R:R:R390	3.49	No	No	0	7	6
221	R:R:A456	R:R:S201	3.42	No	No	0	8	8
222	R:R:E469	R:R:Y211	3.37	No	No	0	9	2
223	R:R:C460	R:R:I208	3.27	Yes	No	0	9	8
224	R:R:V239	R:R:V243	3.21	No	Yes	0	5	5
225	R:R:A284	R:R:K240	3.21	No	No	0	6	7
226	R:R:F324	R:R:Y320	3.09	No	No	0	7	4
227	L:L:K27	L:L:V31	3.04	No	No	0	0	0
228	R:R:F230	R:R:G452	3.01	Yes	No	0	8	9
229	L:L:S1	R:R:L368	3	No	No	0	0	4
230	R:R:L385	R:R:S409	3	No	No	0	8	9
231	R:R:L406	R:R:T410	2.95	No	No	0	8	9
232	R:R:G418	R:R:Y421	2.9	No	Yes	0	9	8
233	L:L:E22	L:L:V21	2.85	No	No	0	0	0
234	R:R:I299	R:R:L226	2.85	No	No	0	9	9
235	R:R:L199	R:R:M231	2.83	No	No	0	7	8
236	R:R:K141	R:R:N139	2.8	No	No	0	3	4
237	R:R:P428	R:R:Y429	2.78	No	No	0	7	6
238	L:L:D30	L:L:K26	2.77	No	No	0	0	0
239	R:R:H442	R:R:V183	2.77	No	No	0	5	4
240	R:R:L300	R:R:L373	2.77	No	No	0	8	7
241	R:R:L304	R:R:L377	2.77	No	No	0	5	7
242	R:R:I135	R:R:Q37	2.74	No	No	0	7	7
243	R:R:E317	R:R:K318	2.7	Yes	No	0	6	5
244	R:R:E469	R:R:K472	2.7	No	No	0	9	7
245	R:R:C170	R:R:Y167	2.69	No	No	0	9	5
246	R:R:L41	R:R:Q37	2.66	No	No	0	8	7
247	R:R:H42	R:R:I38	2.65	No	No	0	4	7
248	R:R:F315	R:R:S308	2.64	No	No	0	6	7
249	R:R:H225	R:R:M224	2.63	No	No	0	8	5
250	R:R:F450	R:R:V197	2.62	No	No	0	7	5
251	R:R:R282	R:R:V283	2.62	No	No	0	8	4
252	R:R:F238	R:R:I237	2.51	No	Yes	0	7	7
253	R:R:F454	R:R:I457	2.51	No	No	0	6	6
254	R:R:F461	R:R:I457	2.51	No	No	0	8	6
255	L:L:R20	R:R:K34	2.48	No	No	0	0	4
256	R:R:M189	R:R:R186	2.48	No	No	0	4	5
257	R:R:K405	R:R:R404	2.48	No	No	0	8	6
258	R:R:S475	R:R:W474	2.47	No	No	0	4	5
259	L:L:L24	R:R:R181	2.43	No	No	6	0	3
260	R:R:L174	R:R:R181	2.43	No	No	6	3	3
261	R:R:L215	R:R:Y221	2.34	No	No	0	9	7
262	R:R:N166	R:R:Y145	2.33	No	No	0	7	4
263	R:R:Q402	R:R:Y403	2.25	No	No	0	6	7
264	R:R:Q45	R:R:W112	2.19	No	No	0	7	7
265	R:R:E49	R:R:W112	2.18	No	No	0	6	7
266	R:R:G330	R:R:P332	2.03	No	Yes	0	7	9
267	R:R:C351	R:R:G350	1.96	No	No	0	9	5
268	R:R:A279	R:R:G280	1.95	No	No	0	4	4
269	R:R:A293	R:R:P332	1.87	No	Yes	0	6	9
270	R:R:G194	R:R:V193	1.84	No	No	0	9	6
271	R:R:G323	R:R:V326	1.84	No	No	0	1	4
272	R:R:G330	R:R:V326	1.84	No	No	0	7	4
273	R:R:G350	R:R:T349	1.82	No	No	0	5	5
274	R:R:A144	R:R:C170	1.81	No	No	0	7	9
275	R:R:A279	R:R:A284	1.79	No	No	0	4	6
276	L:L:G12	L:L:L11	1.71	No	No	0	0	0
277	L:L:G12	L:L:L15	1.71	No	No	0	0	0
278	R:R:A347	R:R:T349	1.68	No	No	0	7	5
279	R:R:E169	R:R:G142	1.64	No	No	0	5	5
280	R:R:C462	R:R:I458	1.64	No	No	0	6	8
281	R:R:G464	R:R:Q467	1.64	No	No	0	7	8
282	R:R:S341	R:R:V342	1.62	No	No	0	5	5
283	R:R:A426	R:R:M425	1.61	No	No	0	5	6
284	R:R:C460	R:R:L209	1.59	Yes	No	0	9	7
285	R:R:C217	R:R:L321	1.59	No	Yes	0	8	6
286	R:R:A386	R:R:L406	1.58	No	No	0	6	8
287	R:R:K319	R:R:S316	1.53	No	No	0	6	7
288	R:R:A46	R:R:E49	1.51	No	No	0	5	6
289	R:R:F324	R:R:G323	1.51	No	No	0	7	1
290	L:L:N16	L:L:S17	1.49	No	No	0	0	0
291	R:R:L116	R:R:V129	1.49	No	No	0	5	5
292	R:R:I190	R:R:M189	1.46	No	No	0	6	4
293	R:R:I190	R:R:L187	1.43	No	No	0	6	5
294	R:R:I381	R:R:L306	1.43	No	No	0	9	9
295	R:R:K172	R:R:N139	1.4	No	No	0	3	4
296	R:R:A313	R:R:F314	1.39	No	No	0	7	7
297	R:R:A46	R:R:R43	1.38	No	No	0	5	4
298	R:R:A165	R:R:R146	1.38	No	No	0	7	8
299	R:R:L385	R:R:L389	1.38	No	Yes	0	8	8
300	R:R:I470	R:R:Q467	1.37	No	No	0	5	8
301	R:R:F424	R:R:V439	1.31	Yes	No	0	7	5
302	R:R:R146	R:R:T163	1.29	No	No	0	8	5
303	L:L:H9	L:L:N10	1.28	No	No	0	0	0
304	R:R:V243	R:R:Y278	1.26	Yes	No	0	5	4
305	R:R:H442	R:R:Q438	1.24	No	No	0	5	4
306	L:L:F34	L:L:N33	1.21	No	No	0	0	0
307	R:R:D113	R:R:R146	1.19	No	No	0	9	8
308	R:R:Q47	R:R:R43	1.17	No	No	0	6	4
309	R:R:L321	R:R:Y221	1.17	Yes	No	0	6	7
310	R:R:L321	R:R:W322	1.14	Yes	No	0	6	3
311	L:L:H14	R:R:F184	1.13	No	No	0	0	6
312	R:R:R162	R:R:W164	1	No	No	0	3	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F138	10.9925	4	7	4
2	R:R:Y195	9.454	5	0	7
3	R:R:L202	4.925	4	0	9
4	R:R:R214	10.53	4	8	7
5	R:R:R219	7.17	4	0	9
6	R:R:S229	5.9075	4	2	9
7	R:R:F230	6.41	5	0	8
8	R:R:R233	10.1125	4	1	8
9	R:R:I237	6.905	4	3	7
10	R:R:V243	3.5075	4	0	5
11	R:R:F288	6.456	5	3	7
12	R:R:Y290	5.604	5	2	9
13	R:R:T294	6.195	4	2	8
14	R:R:Y296	9.9925	4	1	7
15	R:R:Y297	5.645	4	0	6
16	R:R:W298	10.6117	6	2	9
17	R:R:F311	7.2375	4	10	6
18	R:R:E317	5.7075	4	9	6
19	R:R:L321	2.08	4	0	6
20	R:R:W329	10.0475	4	2	9
21	R:R:P332	3.33	4	2	9
22	R:R:W339	7.248	5	0	8
23	R:R:R343	9.614	5	0	8
24	R:R:W352	8.22	4	0	8
25	R:R:F378	7.44	4	4	9
26	R:R:L389	4.1425	4	0	8
27	R:R:F417	8.348	5	4	9
28	R:R:Y421	8.89333	6	1	8
29	R:R:F424	6.085	6	1	7
30	R:R:W437	13.2225	4	0	5
31	R:R:E444	9.74	4	1	7
32	R:R:Q451	7.5675	4	0	9
33	R:R:C460	3.165	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Y296	R:R:Y421	53.1269	16.88	Yes	Yes	1	7	8
2	R:R:E444	R:R:Y421	92.8727	5.61	Yes	Yes	1	7	8
3	R:R:I237	R:R:Y195	26.1333	14.51	Yes	Yes	0	7	7
4	R:R:R233	R:R:Y195	44.0519	12.35	Yes	Yes	0	8	7
5	R:R:R233	R:R:Y296	49.869	5.14	Yes	Yes	1	8	7
6	R:R:F288	R:R:I237	19.2593	3.77	Yes	Yes	3	7	7
7	R:R:E444	R:R:F424	91.3835	5.83	Yes	Yes	1	7	7
8	R:R:F424	R:R:Q440	99.5589	11.71	Yes	No	1	7	6
9	R:R:Q440	R:R:T430	100	5.67	No	No	0	6	5
10	R:R:T430	R:R:W437	96.1569	12.13	No	Yes	0	5	5
11	R:R:F184	R:R:W437	79.7144	6.01	No	Yes	0	6	5
12	R:R:F288	R:R:K240	14.1453	8.69	Yes	No	3	7	7
13	L:L:H14	R:R:F184	75.5131	1.13	No	No	0	0	6
14	L:L:H14	R:R:R181	72.0674	10.16	No	No	0	0	3
15	L:L:R20	R:R:Q37	11.8438	15.19	No	No	0	0	7
16	R:R:I135	R:R:Q37	40.9817	2.74	No	No	0	7	7
17	R:R:I135	R:R:P132	22.0587	5.08	No	No	0	7	9
18	R:R:C131	R:R:P132	28.9807	5.65	No	No	0	9	9
19	R:R:C131	R:R:C170	56.2145	7.28	No	No	0	9	9
20	R:R:C170	R:R:Y167	58.7475	2.69	No	No	0	9	5
21	R:R:V171	R:R:Y167	67.3465	5.05	No	No	0	3	5
22	R:R:L174	R:R:V171	68.5387	7.45	No	No	0	3	3
23	R:R:L174	R:R:R181	69.5039	2.43	No	No	6	3	3
24	R:R:F138	R:R:I135	21.9277	8.79	Yes	No	0	4	7
25	R:R:C131	R:R:F138	26.0809	11.17	No	Yes	0	9	4
26	R:R:L41	R:R:Q37	26.6442	2.66	No	No	0	8	7
27	R:R:L41	R:R:Q45	23.7182	3.99	No	No	0	8	7
28	R:R:Q45	R:R:W112	20.7835	2.19	No	No	0	7	7
29	R:R:M441	R:R:W437	15.8049	27.92	No	Yes	0	6	5
30	R:R:S449	R:R:Y195	10.6865	11.45	No	Yes	0	9	7
31	R:R:N295	R:R:R233	48.3536	15.67	No	Yes	0	8	8
32	R:R:F230	R:R:N295	62.4814	10.87	Yes	No	0	8	8
33	R:R:Q451	R:R:Y421	77.1377	6.76	Yes	Yes	0	9	8
34	R:R:F230	R:R:Q451	80.7625	9.37	Yes	Yes	0	8	9
35	R:R:F230	R:R:L202	31.2909	4.87	Yes	Yes	0	8	9
36	R:R:F227	R:R:L202	24.2161	6.09	No	Yes	0	9	9
37	R:R:H420	R:R:Q451	30.5442	8.65	No	Yes	0	8	9
38	R:R:F454	R:R:H420	42.685	4.53	No	No	0	6	8
39	R:R:C460	R:R:F227	21.8054	4.19	Yes	No	0	9	9
40	R:R:C460	R:R:L209	18.2287	1.59	Yes	No	0	9	7
41	R:R:L209	R:R:N220	17.0277	9.61	No	No	0	7	9
42	R:R:N220	R:R:R219	10.9442	7.23	No	Yes	0	9	9
43	R:R:N295	R:R:S229	79.02	8.94	No	Yes	0	8	9
44	R:R:S229	R:R:W298	30.6315	6.18	Yes	Yes	2	9	9
45	R:R:T325	R:R:W298	25.8276	4.85	No	Yes	0	5	9
46	R:R:L321	R:R:T325	24.0501	4.42	Yes	No	0	6	5
47	R:R:C217	R:R:L321	16.9229	1.59	No	Yes	0	8	6
48	R:R:C217	R:R:K318	15.1411	8.08	No	No	0	8	5
49	R:R:E317	R:R:K318	13.3854	2.7	Yes	No	0	6	5
50	R:R:F454	R:R:P415	38.6497	5.78	No	No	0	6	9
51	R:R:I458	R:R:P415	14.2807	5.08	No	No	0	8	9
52	R:R:I458	R:R:Y459	11.1538	13.3	No	No	0	8	8
53	R:R:S229	R:R:T294	51.8954	4.8	Yes	Yes	2	9	8
54	R:R:T294	R:R:Y290	39.2305	6.24	Yes	Yes	2	8	9
55	R:R:A284	R:R:K240	12.4378	3.21	No	No	0	6	7
56	R:R:V336	R:R:Y290	34.1209	5.05	No	Yes	0	7	9
57	R:R:I363	R:R:V336	32.5007	4.61	No	No	0	7	7
58	R:R:I363	R:R:L289	31.0726	11.42	No	No	0	7	7
59	R:R:L289	R:R:W339	29.9458	9.11	No	Yes	0	7	8
60	R:R:R343	R:R:W339	34.0597	9	Yes	Yes	0	8	8
61	R:R:R343	R:R:W352	18.3597	4	Yes	Yes	0	8	8
62	R:R:C351	R:R:W352	11.6124	3.92	No	Yes	0	9	8
63	R:R:P332	R:R:T294	15.3638	5.25	Yes	Yes	2	9	8
64	R:R:I299	R:R:Q451	57.1491	5.49	No	Yes	0	9	9
65	R:R:I299	R:R:N374	55.6992	4.25	No	No	0	9	9
66	R:R:L300	R:R:N374	28.0505	4.12	No	No	0	8	9
67	R:R:L300	R:R:S370	25.7009	7.51	No	No	0	8	7
68	R:R:S370	R:R:Y297	24.5349	6.36	No	Yes	0	7	6
69	R:R:P366	R:R:Y297	21.2857	4.17	No	Yes	0	9	6
70	R:R:F417	R:R:N374	41.8552	6.04	Yes	No	0	9	9
71	R:R:E317	R:R:L309	11.3329	6.63	Yes	No	9	6	8
72	R:R:F378	R:R:F417	36.9683	11.79	Yes	Yes	4	9	9
73	R:R:F378	R:R:V419	23.6615	6.55	Yes	No	0	9	7
74	R:R:F375	R:R:V419	44.3925	5.24	No	No	0	7	7
75	R:R:F375	R:R:I379	40.7153	3.77	No	No	0	7	5
76	R:R:I379	R:R:N380	37.0032	5.66	No	No	0	5	8
77	R:R:H307	R:R:N380	19.5301	7.65	No	No	0	8	8
78	R:R:F311	R:R:H307	13.7654	16.97	Yes	No	0	6	8
79	R:R:M414	R:R:P415	29.531	5.03	No	No	0	8	9
80	R:R:M414	R:R:V419	28.7973	4.56	No	No	0	8	7
81	R:R:N380	R:R:R383	15.6258	7.23	No	No	0	8	8
82	R:R:F311	R:R:R383	13.7043	4.28	Yes	No	0	6	8
83	R:R:F311	R:R:V384	19.6262	3.93	Yes	No	10	6	8
84	R:R:G330	R:R:P332	13.0492	2.03	No	Yes	0	7	9
85	R:R:G330	R:R:V326	11.2106	1.84	No	No	0	7	4
86	R:R:F335	R:R:P366	18.5082	13	No	No	0	5	9
87	R:R:I362	R:R:W339	17.4993	5.87	No	Yes	0	8	8
88	R:R:F335	R:R:I362	17.805	6.28	No	No	0	5	8
89	R:R:F378	R:R:V382	17.9361	6.55	Yes	No	0	9	7
90	R:R:T410	R:R:V382	16.6084	7.93	No	No	0	9	7
91	R:R:K388	R:R:V384	15.735	4.55	No	No	0	9	8
92	R:R:K388	R:R:T387	11.8133	6.01	No	No	0	9	7
93	R:R:L406	R:R:T410	15.2721	2.95	No	No	0	8	9
94	R:R:L389	R:R:L406	12.5731	4.15	Yes	No	0	8	8
95	R:R:F447	R:R:H420	18.1282	4.53	No	No	0	5	8
96	R:R:F424	R:R:Y443	16.3071	7.22	Yes	No	0	7	4
97	R:R:E49	R:R:W112	11.9268	2.18	No	No	0	6	7
98	R:R:F447	R:R:Y443	16.6084	11.35	No	No	0	5	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:V2	R:R:Q364	10.03	5	No	No	0	7	0	1
L:L:V2	R:R:I367	4.61	5	No	No	0	7	0	1
L:L:S3	R:R:E444	14.37	0	No	Yes	0	7	0	1
L:L:E4	R:R:I237	6.83	3	No	Yes	0	7	0	1
L:L:E4	R:R:F288	8.16	3	No	Yes	0	7	0	1
L:L:E4	R:R:M445	4.06	3	No	No	0	6	0	1
L:L:I5	R:R:Q364	15.1	5	No	No	0	7	0	1
L:L:Q6	R:R:T430	8.5	0	No	No	0	5	0	1
L:L:L7	R:R:W437	6.83	0	No	Yes	0	5	0	1
L:L:M8	R:R:K240	8.64	3	No	No	0	7	0	1
L:L:M8	R:R:F288	3.73	3	No	Yes	0	7	0	1
L:L:L11	R:R:F184	12.18	0	No	No	0	6	0	1
L:L:H14	R:R:R181	10.16	0	No	No	0	3	0	1
L:L:E19	R:R:K34	21.6	0	No	No	0	4	0	1
L:L:R20	R:R:Q37	15.19	0	No	No	0	7	0	1
L:L:W23	R:R:K34	12.76	0	No	No	0	4	0	1
L:L:L24	R:R:L174	4.15	6	No	No	0	3	0	1
L:L:K27	R:R:I115	4.36	0	No	No	0	5	0	1
L:L:V31	R:R:Y167	6.31	0	No	No	0	5	0	1
L:L:F34	R:R:R162	5.34	0	No	No	0	3	0	1
R:R:V171	R:R:Y167	5.05	0	No	No	3	5	2	1
R:R:L174	R:R:V171	7.45	6	No	No	3	3	1	2
R:R:F184	R:R:W437	6.01	0	No	Yes	6	5	1	1
R:R:I237	R:R:Y195	14.51	3	Yes	Yes	7	7	1	2
R:R:F288	R:R:S236	7.93	3	Yes	No	7	7	1	2
R:R:F288	R:R:I237	3.77	3	Yes	Yes	7	7	1	1
R:R:F288	R:R:K240	8.69	3	Yes	No	7	7	1	1
R:R:I367	R:R:Y296	12.09	0	No	Yes	7	7	1	2
R:R:Y296	R:R:Y421	16.88	1	Yes	Yes	7	8	2	2
R:R:L368	R:R:M425	12.72	0	No	No	4	6	1	2
R:R:E444	R:R:Y421	5.61	1	Yes	Yes	7	8	1	2
R:R:N448	R:R:Y421	13.96	1	No	Yes	6	8	2	2
R:R:F424	R:R:Q440	11.71	1	Yes	No	7	6	2	2
R:R:E444	R:R:F424	5.83	1	Yes	Yes	7	7	1	2
R:R:T430	R:R:W437	12.13	0	No	Yes	5	5	1	1
R:R:Q440	R:R:T430	5.67	1	No	No	6	5	2	1
R:R:M441	R:R:W437	27.92	0	No	Yes	6	5	2	1
R:R:E444	R:R:N448	13.15	1	Yes	No	7	6	1	2
R:R:A284	R:R:K240	3.21	0	No	No	6	7	2	1
L:L:S1	R:R:L368	3	0	No	No	0	4	0	1
R:R:I135	R:R:Q37	2.74	0	No	No	7	7	2	1
R:R:C170	R:R:Y167	2.69	0	No	No	9	5	2	1
R:R:L41	R:R:Q37	2.66	0	No	No	8	7	2	1
R:R:F238	R:R:I237	2.51	0	No	Yes	7	7	2	1
L:L:R20	R:R:K34	2.48	0	No	No	0	4	0	1
L:L:L24	R:R:R181	2.43	6	No	No	0	3	0	1
R:R:L174	R:R:R181	2.43	6	No	No	3	3	1	1
L:L:H14	R:R:F184	1.13	0	No	No	0	6	0	1
R:R:R162	R:R:W164	1	0	No	No	3	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7VVN_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.68
Number of Linked Nodes	297
Number of Links	312
Number of Hubs	33
Number of Links mediated by Hubs	124
Number of Communities	10
Number of Nodes involved in Communities	42
Number of Links involved in Communities	48

Path Summary
Number Of Nodes in MetaPath	99
Number Of Links MetaPath	98
Number of Shortest Paths	56728
Length Of Smallest Path	3
Average Path Length	16.8612
Length of Longest Path	40
Minimum Path Strength	1.155
Average Path Strength	6.94464
Maximum Path Strength	20.025
Minimum Path Correlation	0.7
Average Path Correlation	0.963164
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	62.6383
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	37.2838
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • protein binding • binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to stimulus • response to stimulus • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • cellular process • cell population proliferation • regulation of biological process • regulation of cellular process • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • cell projection membrane • synapse • cell junction • cell body • G-protein beta-subunit binding • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • parathyroid hormone receptor binding • signaling receptor binding • G protein-coupled receptor binding • type 1 parathyroid hormone receptor binding • molecular transducer activity • molecular function activator activity • signaling receptor activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • peptide hormone receptor binding • hormone receptor binding • hormone activity • response to xenobiotic stimulus • response to parathyroid hormone • magnesium ion homeostasis • inorganic ion homeostasis • chemical homeostasis • homeostatic process • monoatomic ion homeostasis • monoatomic cation homeostasis • ossification • bone mineralization • biomineral tissue development • tissue development • multicellular organismal-level homeostasis • homeostasis of number of cells within a tissue • anatomical structure homeostasis • tissue homeostasis • homeostasis of number of cells • biosynthetic process • metabolic process • macromolecule metabolic process • macromolecule biosynthetic process • skeletal system development • regulation of biosynthetic process • positive regulation of biological process • regulation of macromolecule metabolic process • gene expression • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • positive regulation of macromolecule metabolic process • regulation of metabolic process • positive regulation of cellular process • RNA metabolic process • primary metabolic process • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • RNA biosynthetic process • nucleobase-containing compound metabolic process • DNA-templated transcription • nucleic acid biosynthetic process • transcription by RNA polymerase II • negative regulation of apoptotic process in bone marrow cell • negative regulation of programmed cell death • apoptotic process in bone marrow cell • regulation of apoptotic process in bone marrow cell • regulation of apoptotic process • negative regulation of biological process • regulation of programmed cell death • negative regulation of apoptotic process • negative regulation of cellular process • regulation of generation of precursor metabolites and energy • regulation of primary metabolic process • positive regulation of glycogen metabolic process • regulation of small molecule metabolic process • small molecule metabolic process • carbohydrate biosynthetic process • hexose metabolic process • positive regulation of glucose metabolic process • positive regulation of glycogen biosynthetic process • energy reserve metabolic process • positive regulation of carbohydrate metabolic process • regulation of glycogen metabolic process • monosaccharide metabolic process • regulation of glycogen biosynthetic process • glucan biosynthetic process • energy derivation by oxidation of organic compounds • regulation of glucan biosynthetic process • regulation of polysaccharide metabolic process • polysaccharide metabolic process • glucan metabolic process • regulation of carbohydrate metabolic process • regulation of glucose metabolic process • carbohydrate metabolic process • polysaccharide biosynthetic process • glycogen metabolic process • generation of precursor metabolites and energy • glycogen biosynthetic process • regulation of polysaccharide biosynthetic process • regulation of carbohydrate biosynthetic process • positive regulation of small molecule metabolic process • glucose metabolic process • phosphate ion homeostasis • cell-cell signaling • intracellular calcium ion homeostasis • calcium ion homeostasis • cellular homeostasis • intracellular monoatomic cation homeostasis • intracellular chemical homeostasis • intracellular monoatomic ion homeostasis • regulation of developmental process • regulation of biomineral tissue development • regulation of bone mineralization • positive regulation of ossification • positive regulation of developmental process • positive regulation of biomineral tissue development • regulation of multicellular organismal process • regulation of multicellular organismal development • positive regulation of bone mineralization • positive regulation of multicellular organismal process • regulation of ossification • response to ethanol • response to metal ion • response to lead ion • positive regulation of cell population proliferation • positive regulation of cell proliferation in bone marrow • cell proliferation in bone marrow • regulation of cell proliferation in bone marrow • regulation of cell population proliferation • response to nutrient levels • response to vitamin D • response to nutrient • response to vitamin • hormone-mediated signaling pathway • apoptotic signaling pathway • hormone-mediated apoptotic signaling pathway • nucleoside phosphate metabolic process • ribose phosphate metabolic process • cAMP metabolic process • cyclic purine nucleotide metabolic process • carbohydrate derivative metabolic process • nucleotide metabolic process • cyclic nucleotide metabolic process • purine-containing compound metabolic process • purine nucleotide metabolic process • ribonucleotide metabolic process • organophosphate metabolic process • nucleobase-containing small molecule metabolic process • phosphate-containing compound metabolic process • purine ribonucleotide metabolic process • phosphorus metabolic process • regulation of cartilage development • regulation of chondrocyte differentiation • connective tissue development • cellular developmental process • negative regulation of cartilage development • negative regulation of chondrocyte differentiation • regulation of cell differentiation • cell differentiation • negative regulation of cell differentiation • negative regulation of developmental process • chondrocyte differentiation • negative regulation of multicellular organismal process • cartilage development • negative regulation of metabolic process • negative regulation of gene expression • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of macromolecule metabolic process • regulation of localization • hexose transmembrane transport • D-glucose import • transport • carbohydrate transport • positive regulation of D-glucose transmembrane transport • localization • positive regulation of transmembrane transport • regulation of D-glucose import • positive regulation of D-glucose import • regulation of transport • establishment of localization • transmembrane transport • regulation of transmembrane transport • positive regulation of transport • D-glucose transmembrane transport • regulation of D-glucose transmembrane transport • monosaccharide transmembrane transport • carbohydrate transmembrane transport • positive regulation of cell communication • regulation of signaling • positive regulation of signal transduction • regulation of signal transduction • positive regulation of response to stimulus • regulation of response to stimulus • regulation of cell communication • positive regulation of signaling • response to cadmium ion • small GTPase-mediated signal transduction • Rho protein signal transduction • intracellular signal transduction • intracellular signaling cassette • regulation of leukocyte proliferation • osteoclast proliferation • regulation of osteoclast proliferation • positive regulation of osteoclast proliferation • leukocyte proliferation • positive regulation of leukocyte proliferation • bone maturation • regulation of bone mineralization involved in bone maturation • negative regulation of biomineral tissue development • negative regulation of bone mineralization • ossification involved in bone maturation • bone development • bone mineralization involved in bone maturation • developmental maturation • negative regulation of bone mineralization involved in bone maturation • negative regulation of ossification • anatomical structure maturation • animal organ maturation • positive regulation of DNA-templated transcription • regulation of RNA metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of nucleobase-containing compound metabolic process • positive regulation of transcription by RNA polymerase II • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • regulation of inositol phosphate biosynthetic process • alcohol metabolic process • positive regulation of phosphate metabolic process • inositol phosphate metabolic process • regulation of phosphate metabolic process • polyol biosynthetic process • polyol metabolic process • positive regulation of phosphorus metabolic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • positive regulation of inositol phosphate biosynthetic process • organophosphate biosynthetic process • inositol phosphate biosynthetic process • alcohol biosynthetic process • regulation of phosphorus metabolic process • positive regulation of alcohol biosynthetic process • tissue remodeling • bone remodeling • bone resorption • response to fibroblast growth factor • response to growth factor • identical protein binding • protein homodimerization activity • protein dimerization activity • amide binding • peptide hormone binding • hormone binding • peptide receptor activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • transmembrane signaling receptor activity • parathyroid hormone receptor activity • osteoblast development • cell development • osteoblast differentiation • embryo development ending in birth or egg hatching • chordate embryonic development • embryo development • in utero embryonic development • cell maturation • cell surface receptor signaling pathway • negative regulation of cell population proliferation • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • apical part of cell • apical plasma membrane • basal part of cell • basal plasma membrane • basolateral plasma membrane • receptor complex
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q03431
Sequence	>7VVN_nogp_Chain_R T K E E Q I F L L H R A Q A Q C E E W D H I L C V P C P D Y I F N H K G H A Y R R T W A N Y S E C V K F L R E V F D R L G M I Y T V G Y S V S L A S L T V A V L I L A Y F R R L H C T R N Y I H M H L F L S F M L R A V S I F V K D A V L Y A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M A F F S E K K Y L W G F T V F G W G L P A V F V A V W V S V R A T L A N T G C W W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L R E T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M A T P Y T L W Q V Q M H Y E M L F N S F Q G F F V A I I Y C F C N G E V Q A E I K K S W S R W T L A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9JR3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	To be published
	9JR3 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	To be published
	9JR2	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	To be published
	9JR2 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	To be published
	8JR9	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371	chim(NtGi1-Gs)/β1/γ2	2.57	2023-08-02	10.1038/s41586-023-06467-w
	8JR9 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371		2.57	2023-08-02	10.1038/s41586-023-06467-w
	7Y36	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Teriparatide	-	Gs/β1/γ2	2.8	2023-07-05	To be published
	7Y36 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Teriparatide	-		2.8	2023-07-05	To be published
	7Y35	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	2.9	2023-07-05	To be published
	7Y35 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		2.9	2023-07-05	To be published
	8GW8	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	KHF	Gs/β1/γ2	2.9	2023-06-14	10.1038/s41586-023-06169-3
	8GW8 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	KHF		2.9	2023-06-14	10.1038/s41586-023-06169-3
	8FLU	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-	Gs/β1/γ2	2.76	2023-04-26	10.1016/j.str.2023.04.002
	8FLU (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-		2.76	2023-04-26	10.1016/j.str.2023.04.002
	8FLT	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-	Gs/β1/γ2	3.03	2023-04-26	10.1016/j.str.2023.04.002
	8FLT (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-		3.03	2023-04-26	10.1016/j.str.2023.04.002
	8FLS	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	3.09	2023-04-26	10.1016/j.str.2023.04.002
	8FLS (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		3.09	2023-04-26	10.1016/j.str.2023.04.002
	8FLR	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	2.94	2023-04-26	10.1016/j.str.2023.04.002
	8FLR (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		2.94	2023-04-26	10.1016/j.str.2023.04.002
	8FLQ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.55	2023-04-26	10.1016/j.str.2023.04.002
	8FLQ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.55	2023-04-26	10.1016/j.str.2023.04.002
	8HAO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	3.76	2022-12-21	10.1038/s41401-022-01032-z
	8HAO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.76	2022-12-21	10.1038/s41401-022-01032-z
	8HAF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	chim(NtGi1-Gs)/β1/γ2	3.25	2022-12-21	10.1038/s41401-022-01032-z
	8HAF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.25	2022-12-21	10.1038/s41401-022-01032-z
	8HA0	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	2.62	2022-12-21	10.1038/s41401-022-01032-z
	8HA0 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.62	2022-12-21	10.1038/s41401-022-01032-z
	7VVO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	4.1	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		4.1	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVN	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVN (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVM	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVM (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVL	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVL (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVK	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.3	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVK (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.3	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVJ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVJ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	6NBI	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	4	2019-04-17	10.1126/science.aav7942
	6NBI (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		4	2019-04-17	10.1126/science.aav7942
	6NBH	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	3.5	2019-04-17	10.1126/science.aav7942
	6NBH (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		3.5	2019-04-17	10.1126/science.aav7942
	6NBF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	3	2019-04-17	10.1126/science.aav7942
	6NBF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		3	2019-04-17	10.1126/science.aav7942
	6FJ3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	-	2.5	2018-11-21	10.1038/s41594-018-0151-4

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7VVN_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.