psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:V2	R:R:Y296	3.79	No	Yes	1	0	7
2	L:L:V2	R:R:Q364	10.03	No	Yes	1	0	7
3	L:L:V2	R:R:I367	4.61	No	No	1	0	7
4	L:L:S3	R:R:E444	11.5	No	Yes	1	0	7
5	L:L:S3	R:R:N448	4.47	No	Yes	1	0	6
6	L:L:E4	R:R:Y195	10.1	Yes	Yes	1	0	7
7	L:L:E4	R:R:R233	11.63	Yes	Yes	1	0	8
8	L:L:E4	R:R:I237	5.47	Yes	No	1	0	7
9	L:L:E4	R:R:F288	3.5	Yes	Yes	1	0	7
10	L:L:E4	R:R:L292	3.98	Yes	No	1	0	6
11	L:L:E4	R:R:M445	4.06	Yes	Yes	0	0	6
12	L:L:E4	R:R:N448	3.94	Yes	Yes	1	0	6
13	L:L:H5	L:L:H9	16.72	No	Yes	0	0	0
14	L:L:H5	R:R:L289	9	No	Yes	0	0	7
15	L:L:H5	R:R:Q364	16.07	No	Yes	0	0	7
16	L:L:D10	L:L:Q6	5.22	No	Yes	1	0	0
17	L:L:Q6	R:R:Y429	12.4	Yes	Yes	1	0	6
18	L:L:Q6	R:R:W437	4.38	Yes	Yes	1	0	5
19	L:L:Q6	R:R:Q440	5.12	Yes	No	0	0	6
20	L:L:Q6	R:R:M441	6.8	Yes	No	1	0	6
21	L:L:L7	R:R:L187	5.54	No	Yes	0	0	5
22	L:L:L7	R:R:M445	5.65	No	Yes	0	0	6
23	L:L:L8	R:R:K240	4.23	No	Yes	0	0	7
24	L:L:L8	R:R:Y245	4.69	No	Yes	4	0	4
25	L:L:L8	R:R:D353	8.14	No	Yes	4	0	5
26	L:L:H9	R:R:S355	6.97	Yes	No	1	0	7
27	L:L:H9	R:R:K360	10.48	Yes	Yes	1	0	7
28	L:L:H9	R:R:Y429	8.71	Yes	Yes	1	0	6
29	L:L:D10	R:R:V432	5.84	No	Yes	1	0	5
30	L:L:D10	R:R:W437	5.58	No	Yes	1	0	5
31	L:L:K11	R:R:F184	14.89	No	Yes	0	0	6
32	L:L:K11	R:R:Y245	10.75	No	Yes	0	0	4
33	L:L:D17	L:L:K13	5.53	No	No	0	0	0
34	L:L:S14	R:R:E180	4.31	No	Yes	1	0	3
35	L:L:S14	R:R:F184	6.61	No	Yes	1	0	6
36	L:L:I15	L:L:R19	6.26	No	No	0	0	0
37	L:L:D17	L:L:Q16	5.22	No	Yes	6	0	0
38	L:L:Q16	L:L:R20	3.5	Yes	Yes	6	0	0
39	L:L:Q16	R:R:V31	7.16	Yes	No	0	0	6
40	L:L:Q16	R:R:T33	5.67	Yes	No	0	0	7
41	L:L:D17	L:L:R20	9.53	No	Yes	6	0	0
42	L:L:E22	L:L:L18	6.63	No	No	0	0	0
43	L:L:L18	R:R:R181	4.86	No	No	0	0	3
44	L:L:R20	R:R:Q37	3.5	Yes	No	0	0	7
45	L:L:R20	R:R:Y136	17.49	Yes	No	0	0	4
46	L:L:R20	R:R:D137	9.53	Yes	No	0	0	5
47	L:L:R21	R:R:D137	14.29	No	No	0	0	5
48	L:L:L23	R:R:K34	4.23	No	No	0	0	4
49	L:L:L23	R:R:I38	4.28	No	No	0	0	7
50	L:L:L24	R:R:F138	9.74	No	Yes	0	0	4
51	L:L:L28	R:R:Y167	3.52	No	Yes	0	0	5
52	L:L:L28	R:R:V171	2.98	No	No	0	0	3
53	L:L:?29	L:L:K30	4.05	No	No	0	0	0
54	R:R:E36	R:R:T33	9.88	No	No	0	6	7
55	R:R:I135	R:R:Q37	6.86	Yes	No	0	7	7
56	R:R:F39	R:R:L40	3.65	No	No	0	7	5
57	R:R:L40	R:R:Y134	3.52	No	Yes	0	5	5
58	R:R:A46	R:R:R43	5.53	No	No	0	5	4
59	R:R:A44	R:R:Y134	5.34	No	Yes	0	7	5
60	R:R:E49	R:R:Q45	3.82	No	No	0	6	7
61	R:R:Q45	R:R:W112	15.33	No	No	0	7	7
62	R:R:Q47	R:R:R51	14.02	No	No	0	6	6
63	R:R:C48	R:R:L52	3.17	No	No	0	8	4
64	R:R:C48	R:R:W112	10.45	No	No	0	8	7
65	R:R:C117	R:R:C48	7.28	No	No	0	9	8
66	R:R:L52	R:R:P110	3.28	No	No	0	4	6
67	R:R:G105	R:R:P123	4.06	No	No	0	5	7
68	R:R:G152	R:R:R106	3	No	No	0	9	1
69	R:R:P107	R:R:P123	5.84	No	No	0	3	7
70	R:R:C108	R:R:C148	7.28	No	No	0	9	9
71	R:R:C108	R:R:W154	15.67	No	No	0	9	9
72	R:R:L120	R:R:P110	3.28	No	No	0	4	6
73	R:R:E111	R:R:R146	4.65	No	Yes	2	7	8
74	R:R:E111	R:R:W154	26.17	No	No	2	7	9
75	R:R:H114	R:R:W112	4.23	No	No	0	4	7
76	R:R:D113	R:R:W118	11.17	No	Yes	2	9	9
77	R:R:D113	R:R:R146	10.72	No	Yes	2	9	8
78	R:R:D113	R:R:Y167	6.9	No	Yes	2	9	5
79	R:R:I115	R:R:P132	3.39	No	Yes	0	5	9
80	R:R:L116	R:R:W118	7.97	No	Yes	2	5	9
81	R:R:L116	R:R:V129	8.94	No	No	2	5	5
82	R:R:V127	R:R:W118	3.68	No	Yes	0	7	9
83	R:R:V129	R:R:W118	6.13	No	Yes	2	5	9
84	R:R:R146	R:R:W118	14.99	Yes	Yes	2	8	9
85	R:R:W118	R:R:Y167	4.82	Yes	Yes	2	9	5
86	R:R:C148	R:R:G121	3.92	No	No	0	9	7
87	R:R:A122	R:R:E125	3.02	No	No	0	1	5
88	R:R:R147	R:R:V126	3.92	No	No	0	3	4
89	R:R:A128	R:R:H143	4.39	No	No	0	5	3
90	R:R:P130	R:R:V129	3.53	No	No	0	5	5
91	R:R:H143	R:R:P130	12.2	No	No	0	3	5
92	R:R:C131	R:R:F138	4.19	No	Yes	3	9	4
93	R:R:C131	R:R:C170	7.28	No	No	3	9	9
94	R:R:P132	R:R:Y134	5.56	Yes	Yes	3	9	5
95	R:R:I135	R:R:P132	5.08	Yes	Yes	3	7	9
96	R:R:F138	R:R:P132	5.78	Yes	Yes	3	4	9
97	R:R:D133	R:R:H140	12.61	No	No	0	2	3
98	R:R:I135	R:R:Y134	13.3	Yes	Yes	3	7	5
99	R:R:F138	R:R:I135	16.33	Yes	Yes	3	4	7
100	R:R:D137	R:R:L174	4.07	No	No	0	5	3
101	R:R:C170	R:R:F138	6.98	No	Yes	3	9	4
102	R:R:K141	R:R:N139	9.79	No	No	0	3	4
103	R:R:G142	R:R:N139	3.39	No	No	0	5	4
104	R:R:E169	R:R:G142	3.27	No	No	0	5	5
105	R:R:H143	R:R:Y145	4.36	No	Yes	0	3	4
106	R:R:A144	R:R:Y167	4	No	Yes	0	7	5
107	R:R:N166	R:R:Y145	11.63	No	Yes	0	7	4
108	R:R:R146	R:R:W154	6	Yes	No	2	8	9
109	R:R:R146	R:R:T163	6.47	Yes	No	0	8	5
110	R:R:A165	R:R:R146	4.15	No	Yes	2	7	8
111	R:R:R146	R:R:Y167	5.14	Yes	Yes	2	8	5
112	R:R:E155	R:R:R147	15.12	No	No	0	4	3
113	R:R:R147	R:R:W164	17.99	No	No	0	3	5
114	R:R:D149	R:R:N151	5.39	No	No	0	5	5
115	R:R:G152	R:R:N151	3.39	No	No	0	9	5
116	R:R:N151	R:R:S153	8.94	No	No	0	5	4
117	R:R:P158	R:R:V157	3.53	No	No	0	4	4
118	R:R:V157	R:R:W164	3.68	No	No	0	4	5
119	R:R:H160	R:R:N161	3.83	No	No	0	4	7
120	R:R:N161	R:R:R162	3.62	No	No	0	7	3
121	R:R:A165	R:R:Y167	5.34	No	Yes	2	7	5
122	R:R:N166	R:R:S168	7.45	No	No	0	7	6
123	R:R:E169	R:R:K172	4.05	No	No	0	5	3
124	R:R:L174	R:R:V171	5.96	No	No	0	3	3
125	R:R:F173	R:R:K172	3.72	No	No	0	3	3
126	R:R:E182	R:R:R179	6.98	No	No	0	2	3
127	R:R:E180	R:R:F184	5.83	Yes	Yes	1	3	6
128	R:R:E180	R:R:V432	5.7	Yes	Yes	1	3	5
129	R:R:E182	R:R:R186	3.49	No	No	0	2	5
130	R:R:R186	R:R:V183	5.23	No	No	0	5	4
131	R:R:F184	R:R:W437	7.02	Yes	Yes	1	6	5
132	R:R:H442	R:R:R186	5.64	No	No	0	5	5
133	R:R:L187	R:R:W437	3.42	Yes	Yes	1	5	5
134	R:R:L187	R:R:M441	7.07	Yes	No	1	5	6
135	R:R:G188	R:R:Y191	5.79	No	Yes	0	5	7
136	R:R:Y191	R:R:Y195	5.96	Yes	Yes	0	7	7
137	R:R:D241	R:R:Y191	11.49	No	Yes	0	8	7
138	R:R:M445	R:R:Y191	5.99	Yes	Yes	0	6	7
139	R:R:G194	R:R:S449	3.71	No	No	1	9	9
140	R:R:F450	R:R:G194	3.01	No	No	1	7	9
141	R:R:R233	R:R:Y195	6.17	Yes	Yes	1	8	7
142	R:R:A234	R:R:Y195	4	No	Yes	0	8	7
143	R:R:I237	R:R:Y195	6.04	No	Yes	1	7	7
144	R:R:F238	R:R:Y195	3.09	No	Yes	0	7	7
145	R:R:S449	R:R:Y195	5.09	No	Yes	1	9	7
146	R:R:F238	R:R:S196	5.28	No	No	0	7	7
147	R:R:F453	R:R:V197	5.24	Yes	No	0	6	5
148	R:R:G452	R:R:S198	3.71	No	No	0	9	9
149	R:R:L199	R:R:M231	4.24	No	No	0	7	8
150	R:R:L199	R:R:V235	4.47	No	No	0	7	4
151	R:R:F453	R:R:S201	5.28	Yes	No	0	6	8
152	R:R:A456	R:R:S201	3.42	No	No	0	8	8
153	R:R:F227	R:R:L202	6.09	No	No	0	9	9
154	R:R:A456	R:R:L202	3.15	No	No	0	8	9
155	R:R:M231	R:R:T203	4.52	No	No	0	8	3
156	R:R:I208	R:R:V204	3.07	No	No	0	8	5
157	R:R:F461	R:R:V204	3.93	No	No	0	8	5
158	R:R:A205	R:R:C460	3.61	No	No	0	9	9
159	R:R:I208	R:R:I470	4.42	No	No	0	8	5
160	R:R:L209	R:R:M224	4.24	No	No	0	7	5
161	R:R:C460	R:R:L209	3.17	No	No	0	9	7
162	R:R:F212	R:R:Y211	9.28	Yes	No	0	7	2
163	R:R:F212	R:R:L215	7.31	Yes	No	7	7	9
164	R:R:E469	R:R:F212	13.99	Yes	Yes	7	9	7
165	R:R:F212	R:R:I470	3.77	Yes	No	0	7	5
166	R:R:F212	R:R:S473	5.28	Yes	No	0	7	4
167	R:R:E469	R:R:R214	10.47	Yes	No	0	9	7
168	R:R:L215	R:R:V466	2.98	No	No	0	9	9
169	R:R:E469	R:R:L215	9.28	Yes	No	7	9	9
170	R:R:H216	R:R:Y221	10.89	No	No	0	8	7
171	R:R:C217	R:R:N220	3.15	No	No	0	8	9
172	R:R:I222	R:R:T218	3.04	No	Yes	8	9	7
173	R:R:T218	R:R:Y305	4.99	Yes	No	8	7	8
174	R:R:E317	R:R:T218	14.11	No	Yes	0	6	7
175	R:R:L321	R:R:T218	4.42	No	Yes	0	6	7
176	R:R:N220	R:R:R219	3.62	No	No	0	9	9
177	R:R:H223	R:R:R219	5.64	No	No	0	9	9
178	R:R:E465	R:R:R219	5.82	No	No	0	9	9
179	R:R:E302	R:R:I222	4.1	Yes	No	0	9	9
180	R:R:I222	R:R:Y305	8.46	No	No	8	9	8
181	R:R:E302	R:R:H223	9.85	Yes	No	0	9	9
182	R:R:H223	R:R:Y459	4.36	No	No	0	9	8
183	R:R:H225	R:R:W298	15.87	No	Yes	1	8	9
184	R:R:H225	R:R:T325	8.21	No	No	1	8	5
185	R:R:H225	R:R:W329	9.52	No	Yes	1	8	9
186	R:R:F230	R:R:L226	7.31	Yes	No	0	8	9
187	R:R:E302	R:R:L226	9.28	Yes	No	0	9	9
188	R:R:F227	R:R:V455	3.93	No	No	0	9	9
189	R:R:L228	R:R:W329	3.42	No	Yes	0	4	9
190	R:R:N295	R:R:S229	7.45	Yes	No	1	8	9
191	R:R:S229	R:R:W298	6.18	No	Yes	1	9	9
192	R:R:S229	R:R:W329	3.71	No	Yes	1	9	9
193	R:R:F230	R:R:N295	18.12	Yes	Yes	1	8	8
194	R:R:F230	R:R:I299	6.28	Yes	Yes	1	8	9
195	R:R:F230	R:R:Q451	7.03	Yes	Yes	1	8	9
196	R:R:F230	R:R:G452	9.03	Yes	No	0	8	9
197	R:R:F291	R:R:L232	14.61	Yes	No	0	5	8
198	R:R:L292	R:R:R233	6.07	No	Yes	1	6	8
199	R:R:N295	R:R:R233	13.26	Yes	Yes	1	8	8
200	R:R:R233	R:R:Y296	8.23	Yes	Yes	1	8	7
201	R:R:R233	R:R:Y421	3.09	Yes	Yes	1	8	8
202	R:R:N448	R:R:R233	3.62	Yes	Yes	1	6	8
203	R:R:F291	R:R:S236	7.93	Yes	No	0	5	7
204	R:R:F288	R:R:I237	3.77	Yes	No	1	7	7
205	R:R:D241	R:R:K240	4.15	No	Yes	0	8	7
206	R:R:K240	R:R:L244	4.23	Yes	Yes	0	7	5
207	R:R:F288	R:R:K240	14.89	Yes	Yes	0	7	7
208	R:R:L244	R:R:Y245	14.07	Yes	Yes	4	5	4
209	R:R:C351	R:R:L244	3.17	No	Yes	4	9	5
210	R:R:D353	R:R:L244	12.21	Yes	Yes	4	5	5
211	R:R:D353	R:R:Y245	3.45	Yes	Yes	4	5	4
212	R:R:C281	R:R:C351	7.28	No	No	0	9	9
213	R:R:N348	R:R:R282	8.44	No	No	0	7	8
214	R:R:R282	R:R:W352	28.99	No	Yes	0	8	8
215	R:R:F287	R:R:V283	5.24	No	No	0	3	4
216	R:R:L289	R:R:V285	2.98	Yes	No	0	7	6
217	R:R:T286	R:R:V340	4.76	No	No	0	7	5
218	R:R:F287	R:R:F291	3.22	No	Yes	0	3	5
219	R:R:F288	R:R:L289	6.09	Yes	Yes	0	7	7
220	R:R:L289	R:R:W339	4.56	Yes	Yes	0	7	8
221	R:R:F291	R:R:Y290	7.22	Yes	Yes	0	5	9
222	R:R:T294	R:R:Y290	8.74	No	Yes	0	8	9
223	R:R:A333	R:R:Y290	4	No	Yes	0	5	9
224	R:R:V336	R:R:Y290	5.05	No	Yes	0	7	9
225	R:R:L292	R:R:Y296	3.52	No	Yes	1	6	7
226	R:R:A293	R:R:I367	3.25	No	No	0	6	7
227	R:R:T294	R:R:W329	9.7	No	Yes	0	8	9
228	R:R:P332	R:R:T294	6.99	No	No	0	9	8
229	R:R:I299	R:R:N295	4.25	Yes	Yes	1	9	8
230	R:R:I367	R:R:Y296	8.46	No	Yes	1	7	7
231	R:R:I371	R:R:Y296	4.84	No	Yes	1	7	7
232	R:R:Y296	R:R:Y421	17.87	Yes	Yes	1	7	8
233	R:R:F327	R:R:Y297	5.16	No	Yes	0	5	6
234	R:R:P332	R:R:Y297	9.74	No	Yes	0	9	6
235	R:R:F335	R:R:Y297	8.25	No	Yes	0	5	6
236	R:R:S370	R:R:Y297	5.09	No	Yes	0	7	6
237	R:R:V301	R:R:W298	9.81	No	Yes	0	8	9
238	R:R:T325	R:R:W298	6.06	No	Yes	1	5	9
239	R:R:G328	R:R:W298	5.63	No	Yes	0	9	9
240	R:R:W298	R:R:W329	22.49	Yes	Yes	1	9	9
241	R:R:I299	R:R:N374	4.25	Yes	No	0	9	9
242	R:R:I299	R:R:Q451	5.49	Yes	Yes	1	9	9
243	R:R:L300	R:R:L304	6.92	No	No	0	8	5
244	R:R:L300	R:R:S370	4.5	No	No	0	8	7
245	R:R:L300	R:R:L373	5.54	No	No	0	8	7
246	R:R:E302	R:R:L416	13.25	Yes	No	0	9	9
247	R:R:F417	R:R:G303	6.02	Yes	No	0	9	9
248	R:R:F324	R:R:L304	3.65	No	No	0	7	5
249	R:R:L309	R:R:Y305	14.07	No	No	0	8	8
250	R:R:I381	R:R:L306	4.28	No	No	0	9	9
251	R:R:F417	R:R:L306	3.65	Yes	No	0	9	9
252	R:R:F311	R:R:H307	16.97	No	No	9	6	8
253	R:R:H307	R:R:L377	3.86	No	No	0	8	7
254	R:R:H307	R:R:N380	7.65	No	No	9	8	8
255	R:R:M312	R:R:S308	4.6	No	No	0	5	7
256	R:R:F315	R:R:L309	7.31	No	No	0	6	8
257	R:R:F311	R:R:I310	5.02	No	No	0	6	8
258	R:R:F311	R:R:N380	7.25	No	No	9	6	8
259	R:R:E317	R:R:F315	3.5	No	No	0	6	6
260	R:R:K319	R:R:S316	3.06	No	No	0	6	7
261	R:R:K319	R:R:Y320	9.55	No	No	0	6	4
262	R:R:F324	R:R:Y320	4.13	No	No	0	7	4
263	R:R:G323	R:R:W322	5.63	No	No	0	1	3
264	R:R:V326	R:R:W322	9.81	No	No	0	4	3
265	R:R:F327	R:R:G328	6.02	No	No	0	5	9
266	R:R:F327	R:R:L331	6.09	No	No	0	5	4
267	R:R:F335	R:R:P366	17.34	No	No	0	5	9
268	R:R:I362	R:R:V338	3.07	No	No	0	8	5
269	R:R:W339	R:R:W352	5.62	Yes	Yes	0	8	8
270	R:R:I362	R:R:W339	3.52	No	Yes	0	8	8
271	R:R:I363	R:R:W339	4.7	No	Yes	0	7	8
272	R:R:V340	R:R:W352	6.13	No	Yes	0	5	8
273	R:R:S341	R:R:V342	3.23	No	No	0	5	5
274	R:R:K359	R:R:V342	4.55	No	No	0	3	5
275	R:R:I362	R:R:V342	4.61	No	No	0	8	5
276	R:R:A347	R:R:R343	6.91	No	Yes	0	7	8
277	R:R:R343	R:R:W352	14.99	Yes	Yes	0	8	8
278	R:R:R343	R:R:S356	7.91	Yes	No	0	8	4
279	R:R:L346	R:R:T345	4.42	No	No	0	3	3
280	R:R:K359	R:R:L346	5.64	No	No	0	3	3
281	R:R:C351	R:R:D353	3.11	No	Yes	4	9	5
282	R:R:K360	R:R:S355	6.12	Yes	No	1	7	7
283	R:R:K359	R:R:S356	6.12	No	No	0	3	4
284	R:R:N358	R:R:W361	4.52	No	Yes	0	4	8
285	R:R:K360	R:R:W361	10.44	Yes	Yes	1	7	8
286	R:R:K360	R:R:Q364	4.07	Yes	Yes	1	7	7
287	R:R:K360	R:R:Y429	13.14	Yes	Yes	1	7	6
288	R:R:Q364	R:R:W361	10.95	Yes	Yes	1	7	8
289	R:R:V365	R:R:W361	4.9	No	Yes	0	5	8
290	R:R:W361	R:R:Y429	3.86	Yes	Yes	1	8	6
291	R:R:Q364	R:R:Y429	9.02	Yes	Yes	1	7	6
292	R:R:P366	R:R:V365	3.53	No	No	0	9	5
293	R:R:I371	R:R:Y421	4.84	No	Yes	1	7	8
294	R:R:I371	R:R:M425	4.37	No	Yes	0	7	6
295	R:R:M425	R:R:V372	3.04	Yes	No	0	6	4
296	R:R:L373	R:R:L377	8.3	No	No	0	7	7
297	R:R:F417	R:R:N374	7.25	Yes	No	0	9	9
298	R:R:F375	R:R:I422	18.84	No	No	0	7	5
299	R:R:F378	R:R:V382	7.87	Yes	No	5	9	7
300	R:R:F378	R:R:T410	5.19	Yes	No	5	9	9
301	R:R:F378	R:R:L413	7.31	Yes	No	5	9	9
302	R:R:F378	R:R:F417	9.65	Yes	Yes	5	9	9
303	R:R:F378	R:R:V419	11.8	Yes	No	0	9	7
304	R:R:N380	R:R:R383	9.64	No	No	0	8	8
305	R:R:L406	R:R:V382	2.98	No	No	0	8	7
306	R:R:T410	R:R:V382	6.35	No	No	5	9	7
307	R:R:R383	R:R:V384	3.92	No	No	0	8	8
308	R:R:K388	R:R:V384	3.04	No	No	0	9	8
309	R:R:L385	R:R:S409	4.5	No	No	0	8	9
310	R:R:A386	R:R:L406	3.15	No	No	0	6	8
311	R:R:E391	R:R:T387	5.64	No	No	0	7	7
312	R:R:K405	R:R:L389	4.23	No	No	0	8	8
313	R:R:L389	R:R:L406	4.15	No	No	0	8	8
314	R:R:E391	R:R:R390	3.49	No	No	0	7	6
315	R:R:Q401	R:R:R400	8.18	No	No	0	6	8
316	R:R:Q401	R:R:R404	14.02	No	No	0	6	6
317	R:R:Q402	R:R:Y403	5.64	Yes	No	0	6	7
318	R:R:K405	R:R:K408	4.31	No	No	0	8	8
319	R:R:K408	R:R:V412	4.55	No	No	0	8	8
320	R:R:F417	R:R:L413	10.96	Yes	No	5	9	9
321	R:R:M414	R:R:P415	5.03	No	No	0	8	9
322	R:R:M414	R:R:V419	3.04	No	No	0	8	7
323	R:R:I458	R:R:P415	5.08	No	No	0	8	9
324	R:R:F417	R:R:L416	4.87	Yes	No	0	9	9
325	R:R:L416	R:R:Y459	18.76	No	No	0	9	8
326	R:R:G418	R:R:H420	3.18	No	Yes	1	9	8
327	R:R:G418	R:R:Q451	3.29	No	Yes	1	9	9
328	R:R:H420	R:R:Y421	15.24	Yes	Yes	1	8	8
329	R:R:H420	R:R:Y443	3.27	Yes	Yes	1	8	4
330	R:R:F447	R:R:H420	9.05	No	Yes	1	5	8
331	R:R:H420	R:R:N448	5.1	Yes	Yes	1	8	6
332	R:R:H420	R:R:Q451	9.89	Yes	Yes	1	8	9
333	R:R:E444	R:R:Y421	3.37	Yes	Yes	1	7	8
334	R:R:N448	R:R:Y421	11.63	Yes	Yes	1	6	8
335	R:R:Q451	R:R:Y421	5.64	Yes	Yes	1	9	8
336	R:R:F424	R:R:V423	6.55	Yes	No	1	7	6
337	R:R:V423	R:R:Y443	7.57	No	Yes	1	6	4
338	R:R:F424	R:R:Q440	10.54	Yes	No	0	7	6
339	R:R:F424	R:R:Y443	8.25	Yes	Yes	1	7	4
340	R:R:E444	R:R:F424	8.16	Yes	Yes	1	7	7
341	R:R:A426	R:R:M425	3.22	No	Yes	0	5	6
342	R:R:Q440	R:R:T427	9.92	No	No	0	6	5
343	R:R:T430	R:R:W437	3.64	No	Yes	0	5	5
344	R:R:V432	R:R:W437	12.26	Yes	Yes	1	5	5
345	R:R:M441	R:R:W437	19.78	No	Yes	1	6	5
346	R:R:F447	R:R:Y443	11.35	No	Yes	1	5	4
347	R:R:E444	R:R:N448	6.57	Yes	Yes	1	7	6
348	R:R:F447	R:R:L446	6.09	No	No	0	5	5
349	R:R:F450	R:R:S449	6.61	No	No	1	7	9
350	R:R:F450	R:R:F454	7.5	No	No	0	7	6
351	R:R:F453	R:R:F454	6.43	Yes	No	0	6	6
352	R:R:F453	R:R:I457	10.05	Yes	No	0	6	6
353	R:R:F461	R:R:I457	6.28	No	No	0	8	6
354	R:R:I458	R:R:Y459	9.67	No	No	0	8	8
355	R:R:N463	R:R:V466	4.43	No	No	0	9	9
356	R:R:E469	R:R:K472	6.75	Yes	No	0	9	7
357	R:R:K472	R:R:R476	7.43	No	No	0	7	7
358	R:R:T478	R:R:W474	3.64	No	No	0	4	5
359	R:R:I190	R:R:M189	2.92	No	No	0	6	4
360	R:R:I190	R:R:M445	2.92	No	Yes	0	6	6
361	R:R:I422	R:R:M425	2.92	No	Yes	0	5	6
362	R:R:P107	R:R:R106	2.88	No	No	0	3	1
363	R:R:E431	R:R:S433	2.87	No	No	0	3	3
364	L:L:L31	R:R:I115	2.85	No	No	0	0	5
365	R:R:L368	R:R:M425	2.83	No	Yes	0	4	6
366	R:R:Q402	R:R:T399	2.83	Yes	No	0	6	6
367	R:R:E35	R:R:T33	2.82	No	No	0	5	7
368	R:R:E177	R:R:T175	2.82	No	No	0	1	1
369	R:R:C460	R:R:F461	2.79	No	No	0	9	8
370	L:L:L23	L:L:L27	2.77	No	No	0	0	0
371	L:L:A1	R:R:Y429	2.67	No	Yes	0	0	6
372	L:L:Q16	R:R:L354	2.66	Yes	No	0	0	5
373	L:L:?29	L:L:L28	2.65	No	No	0	0	0
374	R:R:R476	R:R:S475	2.64	No	No	0	7	4
375	R:R:F238	R:R:T192	2.59	No	No	0	7	7
376	L:L:L31	R:R:H114	2.57	No	No	0	0	4
377	R:R:H442	R:R:L187	2.57	No	Yes	0	5	5
378	R:R:E177	R:R:E180	2.54	No	Yes	0	1	3
379	R:R:L354	R:R:R343	2.43	No	Yes	0	5	8
380	L:L:I15	R:R:Y245	2.42	No	Yes	0	0	4
381	R:R:M32	R:R:Y136	2.39	No	No	0	6	4
382	R:R:D149	R:R:R150	2.38	No	No	0	5	1
383	R:R:L41	R:R:Y134	2.34	No	Yes	0	8	5
384	R:R:Q47	R:R:R43	2.34	No	No	0	6	4
385	R:R:Q402	R:R:R390	2.34	Yes	No	0	6	6
386	R:R:E169	R:R:Y145	2.24	No	Yes	0	5	4
387	R:R:Q438	R:R:W437	2.19	No	Yes	0	4	5
388	R:R:G277	R:R:G350	2.11	No	No	0	4	5
389	R:R:G330	R:R:P332	2.03	No	No	0	7	9
390	R:R:C108	R:R:G152	1.96	No	No	0	9	9
391	R:R:W164	R:R:Y145	1.93	No	Yes	0	5	4
392	R:R:A122	R:R:P123	1.87	No	No	0	1	7
393	R:R:G357	R:R:S355	1.86	No	No	0	6	7
394	R:R:G194	R:R:V193	1.84	No	No	0	9	6
395	R:R:G280	R:R:V283	1.84	No	No	0	4	4
396	R:R:G350	R:R:T349	1.82	No	No	0	5	5
397	R:R:P428	R:R:T427	1.75	No	No	0	7	5
398	L:L:G12	L:L:K11	1.74	No	No	0	0	0
399	R:R:A284	R:R:V243	1.7	No	No	0	6	5
400	R:R:G464	R:R:N463	1.7	No	No	0	7	9
401	R:R:A347	R:R:T349	1.68	No	No	0	7	5
402	R:R:L109	R:R:P110	1.64	No	No	0	5	6
403	R:R:A46	R:R:K50	1.61	No	No	0	5	4
404	R:R:A210	R:R:M224	1.61	No	No	0	4	5
405	R:R:T435	R:R:V439	1.59	No	No	0	1	5
406	R:R:A234	R:R:L199	1.58	No	No	0	8	7
407	R:R:I376	R:R:V372	1.54	No	No	0	4	4
408	R:R:K405	R:R:S409	1.53	No	No	0	8	9
409	R:R:M231	R:R:V206	1.52	No	No	0	8	5
410	R:R:A46	R:R:E49	1.51	No	No	0	5	6
411	R:R:G124	R:R:R150	1.5	No	No	0	7	1
412	R:R:L331	R:R:V334	1.49	No	No	0	4	4
413	R:R:L436	R:R:V439	1.49	No	No	0	4	5
414	R:R:L207	R:R:T203	1.47	No	No	0	3	3
415	R:R:N176	R:R:T178	1.46	No	No	0	3	3
416	R:R:I470	R:R:K471	1.45	No	No	0	5	5
417	L:L:K26	L:L:K30	1.44	No	No	0	0	0
418	R:R:E431	R:R:V432	1.43	No	Yes	0	3	5
419	R:R:Q401	R:R:T399	1.42	No	No	0	6	6
420	R:R:L411	R:R:M414	1.41	No	No	0	8	8
421	L:L:L27	R:R:L41	1.38	No	No	0	0	8
422	R:R:L407	R:R:L411	1.38	No	No	0	8	8
423	R:R:L156	R:R:N161	1.37	No	No	0	4	7
424	R:R:P119	R:R:W118	1.35	No	Yes	0	6	9
425	R:R:L389	R:R:Q402	1.33	No	Yes	0	8	6
426	L:L:S14	R:R:R181	1.32	No	No	0	0	3
427	R:R:H216	R:R:M224	1.31	No	No	0	8	5
428	R:R:A344	R:R:W352	1.3	No	Yes	0	4	8
429	R:R:F375	R:R:I379	1.26	No	No	0	7	5
430	R:R:F378	R:R:I379	1.26	Yes	No	0	9	5
431	R:R:F315	R:R:M312	1.24	No	No	0	6	5
432	R:R:S475	R:R:W474	1.24	No	No	0	4	5
433	R:R:F424	R:R:L436	1.22	Yes	No	0	7	4
434	R:R:T478	R:R:W477	1.21	No	No	0	4	4
435	R:R:H216	R:R:R213	1.13	No	No	0	8	8
436	L:L:H32	R:R:Y167	1.09	No	Yes	0	0	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:E4	6.09714	7	1	0
2	L:L:Q6	6.784	5	1	0
3	L:L:H9	10.72	4	1	0
4	L:L:Q16	4.842	5	6	0
5	L:L:R20	8.71	5	6	0
6	R:R:W118	7.15857	7	2	9
7	R:R:P132	4.9525	4	3	9
8	R:R:Y134	6.012	5	3	5
9	R:R:I135	10.3925	4	3	7
10	R:R:F138	8.604	5	3	4
11	R:R:Y145	5.04	4	0	4
12	R:R:R146	7.44571	7	2	8
13	R:R:Y167	4.40143	7	2	5
14	R:R:E180	4.595	4	1	3
15	R:R:F184	8.5875	4	1	6
16	R:R:L187	4.65	4	1	5
17	R:R:Y191	7.3075	4	0	7
18	R:R:Y195	5.77857	7	1	7
19	R:R:F212	7.926	5	7	7
20	R:R:T218	6.64	4	8	7
21	R:R:F230	9.554	5	1	8
22	R:R:R233	7.43857	7	1	8
23	R:R:K240	6.875	4	0	7
24	R:R:L244	8.42	4	4	5
25	R:R:Y245	7.076	5	4	4
26	R:R:F288	7.0625	4	1	7
27	R:R:L289	5.6575	4	0	7
28	R:R:Y290	6.2525	4	0	9
29	R:R:F291	8.245	4	0	5
30	R:R:N295	10.77	4	1	8
31	R:R:Y296	7.785	6	1	7
32	R:R:Y297	7.06	4	0	6
33	R:R:W298	11.0067	6	1	9
34	R:R:I299	5.0675	4	1	9
35	R:R:E302	9.12	4	0	9
36	R:R:W329	9.768	5	1	9
37	R:R:W339	4.6	4	0	8
38	R:R:R343	8.06	4	0	8
39	R:R:W352	11.406	5	0	8
40	R:R:D353	6.7275	4	4	5
41	R:R:K360	8.85	5	1	7
42	R:R:W361	6.934	5	1	8
43	R:R:Q364	10.028	5	1	7
44	R:R:F378	7.18	6	5	9
45	R:R:Q402	3.035	4	0	6
46	R:R:F417	7.06667	6	5	9
47	R:R:H420	7.62167	6	1	8
48	R:R:Y421	8.81143	7	1	8
49	R:R:F424	6.944	5	1	7
50	R:R:M425	3.276	5	0	6
51	R:R:Y429	8.3	6	1	6
52	R:R:V432	6.3075	4	1	5
53	R:R:W437	7.28375	8	1	5
54	R:R:Y443	7.61	4	1	4
55	R:R:E444	7.4	4	1	7
56	R:R:M445	4.655	4	0	6
57	R:R:N448	5.88833	6	1	6
58	R:R:Q451	6.268	5	1	9
59	R:R:F453	6.75	4	0	6
60	R:R:E469	10.1225	4	7	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:V2	R:R:Y296	10.573	3.79	No	Yes	1	0	7
2	L:L:E4	R:R:R233	38.6043	11.63	Yes	Yes	1	0	8
3	R:R:R233	R:R:Y195	22.0749	6.17	Yes	Yes	1	8	7
4	R:R:I237	R:R:Y195	15.7652	6.04	No	Yes	1	7	7
5	L:L:E4	R:R:F288	61.3898	3.5	Yes	Yes	1	0	7
6	L:L:V2	R:R:Q364	11.1784	10.03	No	Yes	1	0	7
7	L:L:H5	R:R:Q364	19.1652	16.07	No	Yes	0	0	7
8	L:L:H5	R:R:L289	28.4243	9	No	Yes	0	0	7
9	R:R:F288	R:R:L289	76.8215	6.09	Yes	Yes	0	7	7
10	L:L:E4	R:R:M445	13.1116	4.06	Yes	Yes	0	0	6
11	R:R:Q364	R:R:Y429	10.053	9.02	Yes	Yes	1	7	6
12	L:L:Q6	R:R:Y429	19.838	12.4	Yes	Yes	1	0	6
13	L:L:Q6	R:R:W437	17.4305	4.38	Yes	Yes	1	0	5
14	L:L:Q6	R:R:Q440	11.355	5.12	Yes	No	0	0	6
15	L:L:L7	R:R:M445	13.4708	5.65	No	Yes	0	0	6
16	R:R:F288	R:R:K240	18.6313	14.89	Yes	Yes	0	7	7
17	R:R:K240	R:R:L244	10.4539	4.23	Yes	Yes	0	7	5
18	R:R:F184	R:R:W437	11.8274	7.02	Yes	Yes	1	6	5
19	L:L:Q16	R:R:L354	85.9397	2.66	Yes	No	0	0	5
20	R:R:L354	R:R:R343	86.6205	2.43	No	Yes	0	5	8
21	R:R:R343	R:R:W352	89.6116	14.99	Yes	Yes	0	8	8
22	R:R:W339	R:R:W352	93.3986	5.62	Yes	Yes	0	8	8
23	R:R:L289	R:R:W339	100	4.56	Yes	Yes	0	7	8
24	L:L:Q16	L:L:R20	80.7018	3.5	Yes	Yes	6	0	0
25	L:L:R20	R:R:Q37	33.1779	3.5	Yes	No	0	0	7
26	L:L:R20	R:R:D137	52.9186	9.53	Yes	No	0	0	5
27	R:R:I135	R:R:Q37	32.2351	6.86	Yes	No	0	7	7
28	L:L:L28	R:R:V171	49.4711	2.98	No	No	0	0	3
29	R:R:L174	R:R:V171	50.3404	5.96	No	No	0	3	3
30	R:R:D137	R:R:L174	51.2038	4.07	No	No	0	5	3
31	L:L:L28	R:R:Y167	45.9659	3.52	No	Yes	0	0	5
32	R:R:I135	R:R:P132	18.1649	5.08	Yes	Yes	3	7	9
33	R:R:I115	R:R:P132	17.6171	3.39	No	Yes	0	5	9
34	L:L:L31	R:R:I115	16.6247	2.85	No	No	0	0	5
35	L:L:L31	R:R:H114	15.6263	2.57	No	No	0	0	4
36	R:R:H114	R:R:W112	14.6141	4.23	No	No	0	4	7
37	R:R:R146	R:R:Y167	18.6948	5.14	Yes	Yes	2	8	5
38	R:R:R146	R:R:W154	16.6068	6	Yes	No	2	8	9
39	R:R:C108	R:R:W154	15.6283	15.67	No	No	0	9	9
40	R:R:C108	R:R:G152	12.5737	1.96	No	No	0	9	9
41	R:R:W118	R:R:Y167	22.6723	4.82	Yes	Yes	2	9	5
42	R:R:V129	R:R:W118	19.6356	6.13	No	Yes	2	5	9
43	R:R:P130	R:R:V129	18.671	3.53	No	No	0	5	5
44	R:R:H143	R:R:P130	17.6667	12.2	No	No	0	3	5
45	R:R:H143	R:R:Y145	15.6462	4.36	No	Yes	0	3	4
46	R:R:S449	R:R:Y195	48.9868	5.09	No	Yes	1	9	7
47	R:R:F450	R:R:S449	45.4776	6.61	No	No	1	7	9
48	R:R:F450	R:R:F454	44.5011	7.5	No	No	0	7	6
49	R:R:F453	R:R:F454	43.3698	6.43	Yes	No	0	6	6
50	R:R:N295	R:R:R233	53.788	13.26	Yes	Yes	1	8	8
51	R:R:F230	R:R:N295	18.7682	18.12	Yes	Yes	1	8	8
52	R:R:F453	R:R:I457	35.3393	10.05	Yes	No	0	6	6
53	R:R:F461	R:R:I457	34.1762	6.28	No	No	0	8	6
54	R:R:F461	R:R:V204	23.5298	3.93	No	No	0	8	5
55	R:R:I208	R:R:V204	22.327	3.07	No	No	0	8	5
56	R:R:C460	R:R:F461	10.0808	2.79	No	No	0	9	8
57	R:R:I208	R:R:I470	21.1202	4.42	No	No	0	8	5
58	R:R:F212	R:R:I470	18.6948	3.77	Yes	No	0	7	5
59	R:R:E469	R:R:F212	10.0173	13.99	Yes	Yes	7	9	7
60	R:R:F230	R:R:L226	21.6164	7.31	Yes	No	0	8	9
61	R:R:E302	R:R:L226	20.8979	9.28	Yes	No	0	9	9
62	R:R:E302	R:R:I222	11.2875	4.1	Yes	No	0	9	9
63	R:R:I299	R:R:N295	23.758	4.25	Yes	Yes	1	9	8
64	R:R:I299	R:R:N374	29.4961	4.25	Yes	No	0	9	9
65	R:R:F417	R:R:N374	28.7776	7.25	Yes	No	0	9	9
66	R:R:N295	R:R:S229	30.3853	7.45	Yes	No	1	8	9
67	R:R:S229	R:R:W298	12.3236	6.18	No	Yes	1	9	9
68	R:R:S229	R:R:W329	17.4225	3.71	No	Yes	1	9	9
69	R:R:T294	R:R:W329	15.4596	9.7	No	Yes	0	8	9
70	R:R:V365	R:R:W361	12.0279	4.9	No	Yes	0	5	8
71	R:R:P366	R:R:V365	11.2042	3.53	No	No	0	9	5
72	R:R:F335	R:R:P366	10.6405	17.34	No	No	0	5	9
73	R:R:F335	R:R:Y297	10.6445	8.25	No	Yes	0	5	6
74	R:R:I371	R:R:Y296	11.5833	4.84	No	Yes	1	7	7
75	R:R:S370	R:R:Y297	19.0838	5.09	No	Yes	0	7	6
76	R:R:L300	R:R:S370	17.9207	4.5	No	No	0	8	7
77	R:R:L300	R:R:L373	10.8588	5.54	No	No	0	8	7
78	R:R:I371	R:R:M425	18.0239	4.37	No	Yes	0	7	6
79	R:R:F378	R:R:F417	22.9859	9.65	Yes	Yes	5	9	9
80	R:R:F378	R:R:V382	17.2181	7.87	Yes	No	5	9	7
81	R:R:L406	R:R:V382	16.3289	2.98	No	No	0	8	7
82	R:R:L389	R:R:L406	14.4672	4.15	No	No	0	8	8
83	R:R:E444	R:R:F424	10.6921	8.16	Yes	Yes	1	7	7
84	R:R:F424	R:R:Q440	11.5396	10.54	Yes	No	0	7	6
85	L:L:L7	R:R:L187	12.8178	5.54	No	Yes	0	0	5
86	R:R:F288	R:R:I237	15.7057	3.77	Yes	No	1	7	7
87	L:L:E4	R:R:Y195	20.7352	10.1	Yes	Yes	1	0	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:V2	R:R:Y296	3.79	1	No	Yes	0	7	0	1
L:L:V2	R:R:Q364	10.03	1	No	Yes	0	7	0	1
L:L:V2	R:R:I367	4.61	1	No	No	0	7	0	1
L:L:S3	R:R:E444	11.5	1	No	Yes	0	7	0	1
L:L:S3	R:R:N448	4.47	1	No	Yes	0	6	0	1
L:L:E4	R:R:Y195	10.1	1	Yes	Yes	0	7	0	1
L:L:E4	R:R:R233	11.63	1	Yes	Yes	0	8	0	1
L:L:E4	R:R:I237	5.47	1	Yes	No	0	7	0	1
L:L:E4	R:R:F288	3.5	1	Yes	Yes	0	7	0	1
L:L:E4	R:R:L292	3.98	1	Yes	No	0	6	0	1
L:L:E4	R:R:M445	4.06	1	Yes	Yes	0	6	0	1
L:L:E4	R:R:N448	3.94	1	Yes	Yes	0	6	0	1
L:L:H5	R:R:L289	9	0	No	Yes	0	7	0	1
L:L:H5	R:R:Q364	16.07	0	No	Yes	0	7	0	1
L:L:Q6	R:R:Y429	12.4	1	Yes	Yes	0	6	0	1
L:L:Q6	R:R:W437	4.38	1	Yes	Yes	0	5	0	1
L:L:Q6	R:R:Q440	5.12	1	Yes	No	0	6	0	1
L:L:Q6	R:R:M441	6.8	1	Yes	No	0	6	0	1
L:L:L7	R:R:L187	5.54	0	No	Yes	0	5	0	1
L:L:L7	R:R:M445	5.65	0	No	Yes	0	6	0	1
L:L:L8	R:R:K240	4.23	4	No	Yes	0	7	0	1
L:L:L8	R:R:Y245	4.69	4	No	Yes	0	4	0	1
L:L:L8	R:R:D353	8.14	4	No	Yes	0	5	0	1
L:L:H9	R:R:S355	6.97	1	Yes	No	0	7	0	1
L:L:H9	R:R:K360	10.48	1	Yes	Yes	0	7	0	1
L:L:H9	R:R:Y429	8.71	1	Yes	Yes	0	6	0	1
L:L:D10	R:R:V432	5.84	1	No	Yes	0	5	0	1
L:L:D10	R:R:W437	5.58	1	No	Yes	0	5	0	1
L:L:K11	R:R:F184	14.89	0	No	Yes	0	6	0	1
L:L:K11	R:R:Y245	10.75	0	No	Yes	0	4	0	1
L:L:S14	R:R:E180	4.31	1	No	Yes	0	3	0	1
L:L:S14	R:R:F184	6.61	1	No	Yes	0	6	0	1
L:L:Q16	R:R:V31	7.16	6	Yes	No	0	6	0	1
L:L:Q16	R:R:T33	5.67	6	Yes	No	0	7	0	1
L:L:L18	R:R:R181	4.86	0	No	No	0	3	0	1
L:L:R20	R:R:Q37	3.5	6	Yes	No	0	7	0	1
L:L:R20	R:R:Y136	17.49	6	Yes	No	0	4	0	1
L:L:R20	R:R:D137	9.53	6	Yes	No	0	5	0	1
L:L:R21	R:R:D137	14.29	0	No	No	0	5	0	1
L:L:L23	R:R:K34	4.23	0	No	No	0	4	0	1
L:L:L23	R:R:I38	4.28	0	No	No	0	7	0	1
L:L:L24	R:R:F138	9.74	0	No	Yes	0	4	0	1
L:L:L28	R:R:Y167	3.52	0	No	Yes	0	5	0	1
L:L:L28	R:R:V171	2.98	0	No	No	0	3	0	1
R:R:E36	R:R:T33	9.88	0	No	No	6	7	2	1
R:R:I135	R:R:Q37	6.86	3	Yes	No	7	7	2	1
R:R:H114	R:R:W112	4.23	0	No	No	4	7	1	2
R:R:D113	R:R:W118	11.17	2	No	Yes	9	9	2	2
R:R:D113	R:R:R146	10.72	2	No	Yes	9	8	2	2
R:R:D113	R:R:Y167	6.9	2	No	Yes	9	5	2	1
R:R:I115	R:R:P132	3.39	0	No	Yes	5	9	1	2
R:R:R146	R:R:W118	14.99	2	Yes	Yes	8	9	2	2
R:R:W118	R:R:Y167	4.82	2	Yes	Yes	9	5	2	1
R:R:C131	R:R:F138	4.19	3	No	Yes	9	4	2	1
R:R:C131	R:R:C170	7.28	3	No	No	9	9	2	2
R:R:P132	R:R:Y134	5.56	3	Yes	Yes	9	5	2	2
R:R:I135	R:R:P132	5.08	3	Yes	Yes	7	9	2	2
R:R:F138	R:R:P132	5.78	3	Yes	Yes	4	9	1	2
R:R:I135	R:R:Y134	13.3	3	Yes	Yes	7	5	2	2
R:R:F138	R:R:I135	16.33	3	Yes	Yes	4	7	1	2
R:R:D137	R:R:L174	4.07	0	No	No	5	3	1	2
R:R:C170	R:R:F138	6.98	3	No	Yes	9	4	2	1
R:R:A144	R:R:Y167	4	0	No	Yes	7	5	2	1
R:R:A165	R:R:R146	4.15	2	No	Yes	7	8	2	2
R:R:R146	R:R:Y167	5.14	2	Yes	Yes	8	5	2	1
R:R:A165	R:R:Y167	5.34	2	No	Yes	7	5	2	1
R:R:L174	R:R:V171	5.96	0	No	No	3	3	2	1
R:R:E180	R:R:F184	5.83	1	Yes	Yes	3	6	1	1
R:R:E180	R:R:V432	5.7	1	Yes	Yes	3	5	1	1
R:R:F184	R:R:W437	7.02	1	Yes	Yes	6	5	1	1
R:R:L187	R:R:W437	3.42	1	Yes	Yes	5	5	1	1
R:R:L187	R:R:M441	7.07	1	Yes	No	5	6	1	1
R:R:Y191	R:R:Y195	5.96	0	Yes	Yes	7	7	2	1
R:R:D241	R:R:Y191	11.49	0	No	Yes	8	7	2	2
R:R:M445	R:R:Y191	5.99	0	Yes	Yes	6	7	1	2
R:R:R233	R:R:Y195	6.17	1	Yes	Yes	8	7	1	1
R:R:A234	R:R:Y195	4	0	No	Yes	8	7	2	1
R:R:I237	R:R:Y195	6.04	1	No	Yes	7	7	1	1
R:R:F238	R:R:Y195	3.09	0	No	Yes	7	7	2	1
R:R:S449	R:R:Y195	5.09	1	No	Yes	9	7	2	1
R:R:L292	R:R:R233	6.07	1	No	Yes	6	8	1	1
R:R:N295	R:R:R233	13.26	1	Yes	Yes	8	8	2	1
R:R:R233	R:R:Y296	8.23	1	Yes	Yes	8	7	1	1
R:R:R233	R:R:Y421	3.09	1	Yes	Yes	8	8	1	2
R:R:N448	R:R:R233	3.62	1	Yes	Yes	6	8	1	1
R:R:F288	R:R:I237	3.77	1	Yes	No	7	7	1	1
R:R:D241	R:R:K240	4.15	0	No	Yes	8	7	2	1
R:R:K240	R:R:L244	4.23	0	Yes	Yes	7	5	1	2
R:R:F288	R:R:K240	14.89	1	Yes	Yes	7	7	1	1
R:R:L244	R:R:Y245	14.07	4	Yes	Yes	5	4	2	1
R:R:C351	R:R:L244	3.17	4	No	Yes	9	5	2	2
R:R:D353	R:R:L244	12.21	4	Yes	Yes	5	5	1	2
R:R:D353	R:R:Y245	3.45	4	Yes	Yes	5	4	1	1
R:R:L289	R:R:V285	2.98	0	Yes	No	7	6	1	2
R:R:F288	R:R:L289	6.09	1	Yes	Yes	7	7	1	1
R:R:L289	R:R:W339	4.56	0	Yes	Yes	7	8	1	2
R:R:L292	R:R:Y296	3.52	1	No	Yes	6	7	1	1
R:R:A293	R:R:I367	3.25	0	No	No	6	7	2	1
R:R:I367	R:R:Y296	8.46	1	No	Yes	7	7	1	1
R:R:I371	R:R:Y296	4.84	1	No	Yes	7	7	2	1
R:R:Y296	R:R:Y421	17.87	1	Yes	Yes	7	8	1	2
R:R:C351	R:R:D353	3.11	4	No	Yes	9	5	2	1
R:R:K360	R:R:S355	6.12	1	Yes	No	7	7	1	1
R:R:K360	R:R:W361	10.44	1	Yes	Yes	7	8	1	2
R:R:K360	R:R:Q364	4.07	1	Yes	Yes	7	7	1	1
R:R:K360	R:R:Y429	13.14	1	Yes	Yes	7	6	1	1
R:R:Q364	R:R:W361	10.95	1	Yes	Yes	7	8	1	2
R:R:W361	R:R:Y429	3.86	1	Yes	Yes	8	6	2	1
R:R:Q364	R:R:Y429	9.02	1	Yes	Yes	7	6	1	1
R:R:I371	R:R:Y421	4.84	1	No	Yes	7	8	2	2
R:R:H420	R:R:Y421	15.24	1	Yes	Yes	8	8	2	2
R:R:H420	R:R:N448	5.1	1	Yes	Yes	8	6	2	1
R:R:E444	R:R:Y421	3.37	1	Yes	Yes	7	8	1	2
R:R:N448	R:R:Y421	11.63	1	Yes	Yes	6	8	1	2
R:R:F424	R:R:Q440	10.54	1	Yes	No	7	6	2	1
R:R:E444	R:R:F424	8.16	1	Yes	Yes	7	7	1	2
R:R:Q440	R:R:T427	9.92	0	No	No	6	5	1	2
R:R:T430	R:R:W437	3.64	0	No	Yes	5	5	2	1
R:R:V432	R:R:W437	12.26	1	Yes	Yes	5	5	1	1
R:R:M441	R:R:W437	19.78	1	No	Yes	6	5	1	1
R:R:E444	R:R:N448	6.57	1	Yes	Yes	7	6	1	1
R:R:I190	R:R:M445	2.92	0	No	Yes	6	6	2	1
L:L:L31	R:R:I115	2.85	0	No	No	0	5	0	1
R:R:E35	R:R:T33	2.82	0	No	No	5	7	2	1
L:L:A1	R:R:Y429	2.67	0	No	Yes	0	6	0	1
L:L:Q16	R:R:L354	2.66	6	Yes	No	0	5	0	1
L:L:L31	R:R:H114	2.57	0	No	No	0	4	0	1
R:R:H442	R:R:L187	2.57	0	No	Yes	5	5	2	1
R:R:E177	R:R:E180	2.54	0	No	Yes	1	3	2	1
R:R:L354	R:R:R343	2.43	0	No	Yes	5	8	1	2
L:L:I15	R:R:Y245	2.42	0	No	Yes	0	4	0	1
R:R:M32	R:R:Y136	2.39	0	No	No	6	4	2	1
R:R:L41	R:R:Y134	2.34	0	No	Yes	8	5	1	2
R:R:Q438	R:R:W437	2.19	0	No	Yes	4	5	2	1
R:R:G357	R:R:S355	1.86	0	No	No	6	7	2	1
R:R:E431	R:R:V432	1.43	0	No	Yes	3	5	2	1
L:L:L27	R:R:L41	1.38	0	No	No	0	8	0	1
L:L:S14	R:R:R181	1.32	1	No	No	0	3	0	1
L:L:H32	R:R:Y167	1.09	0	No	Yes	0	5	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8FLS_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.98
Number of Linked Nodes	372
Number of Links	436
Number of Hubs	60
Number of Links mediated by Hubs	230
Number of Communities	9
Number of Nodes involved in Communities	84
Number of Links involved in Communities	129

Path Summary
Number Of Nodes in MetaPath	88
Number Of Links MetaPath	87
Number of Shortest Paths	111594
Length Of Smallest Path	3
Average Path Length	16.3271
Length of Longest Path	41
Minimum Path Strength	1.22
Average Path Strength	6.43806
Maximum Path Strength	21.99
Minimum Path Correlation	0.7
Average Path Correlation	0.963483
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	63.6601
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	50.3378
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • identical protein binding • protein homodimerization activity • protein dimerization activity • amide binding • peptide hormone binding • hormone binding • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • parathyroid hormone receptor activity • ossification • bone mineralization • biomineral tissue development • tissue development • skeletal system development • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • osteoblast development • cellular developmental process • cell differentiation • cell development • osteoblast differentiation • embryo development ending in birth or egg hatching • chordate embryonic development • embryo development • in utero embryonic development • anatomical structure maturation • cell maturation • developmental maturation • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • cell surface receptor signaling pathway • negative regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • connective tissue development • chondrocyte differentiation • cartilage development • regulation of inositol phosphate biosynthetic process • alcohol metabolic process • positive regulation of phosphate metabolic process • inositol phosphate metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • regulation of phosphate metabolic process • phosphate-containing compound metabolic process • polyol biosynthetic process • small molecule metabolic process • phosphorus metabolic process • regulation of carbohydrate metabolic process • regulation of biosynthetic process • carbohydrate metabolic process • polyol metabolic process • positive regulation of phosphorus metabolic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • carbohydrate biosynthetic process • primary metabolic process • positive regulation of inositol phosphate biosynthetic process • biosynthetic process • organophosphate metabolic process • organophosphate biosynthetic process • inositol phosphate biosynthetic process • alcohol biosynthetic process • regulation of phosphorus metabolic process • metabolic process • positive regulation of carbohydrate metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • tissue homeostasis • bone resorption • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • apical part of cell • plasma membrane region • apical plasma membrane • basal part of cell • basal plasma membrane • basolateral plasma membrane • receptor complex
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	AIB
PDB Residues	L:L:?29
Environment Details	Open EMBL-EBI Page
Code	AIB
Name	2-aminoisobutyric acid
Synonyms	α,α-dimethylglycine
Identifier
Formula	C4 H9 N O2
Molecular Weight	103.12
SMILES
PubChem	5245672
Formal Charge	0
Total Atoms	16
Total Chiral Atoms	0
Total Bonds	15
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q03431
Sequence	>8FLS_nogp_Chain_R V M T K E E Q I F L L H R A Q A Q C E K R L K E G R P C L P E W D H I L C W P L G A P G E V V A V P C P D Y I Y D F N H K G H A Y R R C D R N G S W E L V P G H N R T W A N Y S E C V K F L T N E T R E R E V F D R L G M I Y T V G Y S V S L A S L T V A V L I L A Y F R R L H C T R N Y I H M H L F L S F M L R A V S I F V K D A V L Y S G Y A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M A F F S E K K Y L W G F T V F G W G L P A V F V A V W V S V R A T L A N T G C W D L S S G N K K W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L R E T T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M A T P Y T E V S G T L W Q V Q M H Y E M L F N S F Q G F F V A I I Y C F C N G E V Q A E I K K S W S R W T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9JR3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	To be published
	9JR3 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	To be published
	9JR2	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	To be published
	9JR2 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	To be published
	8JR9	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371	chim(NtGi1-Gs)/β1/γ2	2.57	2023-08-02	10.1038/s41586-023-06467-w
	8JR9 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371		2.57	2023-08-02	10.1038/s41586-023-06467-w
	7Y36	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Teriparatide	-	Gs/β1/γ2	2.8	2023-07-05	To be published
	7Y36 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Teriparatide	-		2.8	2023-07-05	To be published
	7Y35	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	2.9	2023-07-05	To be published
	7Y35 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		2.9	2023-07-05	To be published
	8GW8	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	KHF	Gs/β1/γ2	2.9	2023-06-14	10.1038/s41586-023-06169-3
	8GW8 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	KHF		2.9	2023-06-14	10.1038/s41586-023-06169-3
	8FLU	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-	Gs/β1/γ2	2.76	2023-04-26	10.1016/j.str.2023.04.002
	8FLU (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-		2.76	2023-04-26	10.1016/j.str.2023.04.002
	8FLT	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-	Gs/β1/γ2	3.03	2023-04-26	10.1016/j.str.2023.04.002
	8FLT (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-		3.03	2023-04-26	10.1016/j.str.2023.04.002
	8FLS	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	3.09	2023-04-26	10.1016/j.str.2023.04.002
	8FLS (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		3.09	2023-04-26	10.1016/j.str.2023.04.002
	8FLR	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	2.94	2023-04-26	10.1016/j.str.2023.04.002
	8FLR (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		2.94	2023-04-26	10.1016/j.str.2023.04.002
	8FLQ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.55	2023-04-26	10.1016/j.str.2023.04.002
	8FLQ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.55	2023-04-26	10.1016/j.str.2023.04.002
	8HAO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	3.76	2022-12-21	10.1038/s41401-022-01032-z
	8HAO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.76	2022-12-21	10.1038/s41401-022-01032-z
	8HAF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	chim(NtGi1-Gs)/β1/γ2	3.25	2022-12-21	10.1038/s41401-022-01032-z
	8HAF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.25	2022-12-21	10.1038/s41401-022-01032-z
	8HA0	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	2.62	2022-12-21	10.1038/s41401-022-01032-z
	8HA0 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.62	2022-12-21	10.1038/s41401-022-01032-z
	7VVO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	4.1	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		4.1	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVN	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVN (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVM	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVM (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVL	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVL (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVK	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.3	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVK (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.3	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVJ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVJ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	6NBI	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	4	2019-04-17	10.1126/science.aav7942
	6NBI (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		4	2019-04-17	10.1126/science.aav7942
	6NBH	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	3.5	2019-04-17	10.1126/science.aav7942
	6NBH (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		3.5	2019-04-17	10.1126/science.aav7942
	6NBF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	3	2019-04-17	10.1126/science.aav7942
	6NBF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		3	2019-04-17	10.1126/science.aav7942
	6FJ3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	-	2.5	2018-11-21	10.1038/s41594-018-0151-4

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