Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:E16 4.5325414
2A:A:Q19 8.716514
3A:A:N23 6.48417
4A:A:Y37 11.7575414
5A:A:H41 8.6475456
6A:A:V214 7.645456
7A:A:F219 6.85571758
8A:A:F222 12.23617
9A:A:D223 6.86754209
10A:A:K233 7.718519
11A:A:W234 8.8775409
12A:A:F238 9.584519
13A:A:V247 4.85754117
14A:A:Q267 5.16404
15A:A:F273 5.99649
16A:A:W277 9.26646
17A:A:W281 13.3917615
18A:A:L282 6.506509
19A:A:F290 7.4385119
20A:A:L296 6.3554216
21A:A:F312 5.5408
22A:A:F315 10.13406
23A:A:E327 7.2525444
24A:A:E330 10.48543
25A:A:K338 13.038545
26A:A:Y339 9.742543
27A:A:F340 11.5585227
28A:A:R342 7.6325444
29A:A:F345 8.9408
30A:A:S349 5.81447
31A:A:R356 7.46402
32A:A:Y358 8.5975404
33A:A:Y360 9.8785128
34A:A:N371 6.61754119
35A:A:R373 7.538555
36A:A:F376 8.656558
37A:A:R385 9.2545125
38A:A:H387 8.36458
39B:B:R22 9.665406
40B:B:L30 6.6675405
41B:B:I37 4.62254162
42B:B:V40 6.0945163
43B:B:L51 8.322519
44B:B:H54 8.875619
45B:B:K57 15.84419
46B:B:Y59 9.0525418
47B:B:M61 4.31406
48B:B:W63 8.132507
49B:B:Q75 11.1075419
50B:B:D76 6.58333619
51B:B:I80 8.64418
52B:B:W82 12.0933619
53B:B:D83 10.98418
54B:B:T86 8.2725416
55B:B:N88 10.5375417
56B:B:K89 8.43333619
57B:B:I93 7.8475467
58B:B:L95 4.7325468
59B:B:W99 9.24719
60B:B:M101 6.8775419
61B:B:Y105 5.276566
62B:B:V112 4.5875468
63B:B:I123 4.998506
64B:B:Y124 5.52714766
65B:B:E138 5.96406
66B:B:H142 8.832519
67B:B:Y145 8.67833618
68B:B:F151 6.19333609
69B:B:S160 5.1725406
70B:B:D163 8.552519
71B:B:L168 5.99406
72B:B:W169 9.955618
73B:B:F180 9.552577
74B:B:H183 9.936579
75B:B:D186 8.96419
76B:B:F199 9.32679
77B:B:V200 10.845436
78B:B:C204 7.2725417
79B:B:D205 6.908579
80B:B:K209 11.528576
81B:B:L210 6.264535
82B:B:W211 10.334578
83B:B:D212 9.72409
84B:B:Q220 9.145437
85B:B:F222 9.5525438
86B:B:H225 9.76429739
87B:B:D228 9.25519
88B:B:I232 5.09438
89B:B:F234 7.835405
90B:B:F235 8.84333696
91B:B:P236 6.7375497
92B:B:N237 8.224595
93B:B:F241 8.945636
94B:B:T243 6.715438
95B:B:D246 6.8475419
96B:B:D247 9.746539
97B:B:R251 10.9343738
98B:B:F253 6.54167636
99B:B:R256 10.87499
100B:B:D258 12.105437
101B:B:M262 6.05504
102B:B:Y264 6.864505
103B:B:H266 7.50254104
104B:B:I269 4.9545104
105B:B:F278 7.025697
106B:B:R283 10.1654169
107B:B:Y289 9.283336107
108B:B:D290 7.68516
109B:B:V296 4.5575405
110B:B:W297 11.284108
111B:B:L300 5.7885166
112B:B:R304 10.2454105
113B:B:L308 9.425407
114B:B:H311 9.1385139
115B:B:R314 18.798518
116B:B:W332 12.91719
117B:B:D333 10.154139
118B:B:L336 5.845417
119B:B:K337 8.69254136
120B:B:W339 12.944139
121B:B:N340 7.625419
122G:G:R27 8.0775438
123G:G:Y40 10.9625496
124G:G:N59 4.465419
125G:G:P60 9.7625419
126G:G:F61 7.87375818
127L:L:V2 6.146520
128L:L:E4 7.6425420
129L:L:I5 7.944520
130L:L:Q6 11.365420
131L:L:M8 6.87520
132L:L:H9 8.454520
133L:L:Q10 6.1225420
134L:L:W14 6.218520
135L:L:R20 10.2875400
136R:R:V31 4.74254266
137R:R:Q37 4.854177
138R:R:W112 10.3154287
139R:R:W118 10.28754189
140R:R:P132 6.9154179
141R:R:Y134 5.976175
142R:R:I135 9.75754177
143R:R:D137 7.65405
144R:R:F138 11.06754174
145R:R:Y145 13.57254294
146R:R:R146 12.6654188
147R:R:W154 8.715409
148R:R:Y167 7.631676185
149R:R:E180 6.1125423
150R:R:F184 10.4225426
151R:R:L187 5.1175425
152R:R:Y191 6.212527
153R:R:Y195 7.74167627
154R:R:F212 8.0654147
155R:R:L215 4.56754149
156R:R:R219 9.29254149
157R:R:N220 6.05254149
158R:R:H225 12.5488
159R:R:F227 5.0675409
160R:R:F230 10.486528
161R:R:M231 3.21508
162R:R:R233 9.435628
163R:R:I237 5.3025427
164R:R:L244 7.54425
165R:R:Y245 10.945424
166R:R:F288 8.675427
167R:R:L289 6.1575427
168R:R:Y290 6.516589
169R:R:F291 10.845405
170R:R:Y296 9.07627
171R:R:Y297 4.806526
172R:R:W298 13.308589
173R:R:I299 4.775429
174R:R:E302 12.0375409
175R:R:Y305 8.098508
176R:R:I310 4.195408
177R:R:F311 10.12254196
178R:R:F314 9.238557
179R:R:Y320 6.0825404
180R:R:W329 11.675489
181R:R:F335 7.834525
182R:R:W339 6.14167628
183R:R:R343 11.5428
184R:R:W352 17.5875428
185R:R:D353 8.9775425
186R:R:Q364 9.1025427
187R:R:F378 7.7625159
188R:R:L389 3.1275408
189R:R:F417 8.181676159
190R:R:H420 9.96528
191R:R:Y421 11.4217628
192R:R:F424 8.526527
193R:R:Y429 14.32526
194R:R:V432 9.0425425
195R:R:W437 12.07525
196R:R:M441 9.71426
197R:R:Y443 7.55524
198R:R:E444 7.6675427
199R:R:M445 6.85526
200R:R:F450 5.48527
201R:R:Q451 7.62529
202R:R:F453 6.4825406
203R:R:N463 7.245409
204R:R:E465 5.414149
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:N23 B:B:N88 13.606414.98YesYes177
2A:A:N23 B:B:K89 15.36864.2YesYes179
3B:B:D76 B:B:H54 13.27343.78YesYes199
4B:B:K89 B:B:W82 14.051415.08YesYes199
5A:A:Y37 B:B:D76 18.09555.75YesYes149
6A:A:R42 A:A:Y37 24.574122.64NoYes194
7A:A:F222 A:A:F238 10.13784.29YesYes179
8A:A:F238 A:A:W234 20.13764.01YesYes099
9A:A:W234 B:B:Y145 38.91115.79YesYes098
10A:A:Q227 B:B:Y145 34.84357.89NoYes098
11A:A:Q227 B:B:N119 55.29925.28NoNo099
12A:A:G206 B:B:N119 55.2655.09NoNo089
13A:A:A226 A:A:G206 55.19941.95NoNo098
14A:A:A226 A:A:G225 55.16671.95NoNo099
15A:A:F208 A:A:G225 55.13423.01NoNo059
16A:A:D223 A:A:F208 55.10333.58YesNo095
17A:A:D223 A:A:L45 54.81144.07YesNo2098
18A:A:L45 A:A:M221 54.95888.48NoNo088
19A:A:F212 A:A:M221 54.90246.22NoNo098
20A:A:F212 A:A:F219 54.798611.79NoYes098
21A:A:R42 B:B:W99 16.23514NoYes199
22A:A:F219 A:A:H41 26.63177.92YesYes586
23A:A:H41 A:A:I383 26.25323.98YesNo568
24A:A:F219 A:A:F376 17.31658.57YesYes588
25A:A:R231 A:A:W234 36.43311NoYes099
26A:A:L46 A:A:R231 18.23546.07NoNo089
27A:A:F246 A:A:L46 17.86726.09NoNo098
28A:A:L272 A:A:R231 18.03239.72NoNo089
29A:A:F246 A:A:L272 17.84887.31NoNo098
30A:A:F219 A:A:V214 10.81673.93YesYes586
31A:A:R373 A:A:V214 10.47755.23YesYes556
32A:A:E370 A:A:R373 24.42525.82NoYes045
33A:A:E370 A:A:R374 24.122811.63NoNo044
34A:A:F290 A:A:H362 10.64556.79YesNo099
35A:A:F290 A:A:V247 16.563.93YesYes1197
36A:A:F376 A:A:R373 14.15877.48YesYes585
37A:A:R374 A:A:T364 14.432610.35NoNo049
38A:A:N292 A:A:V247 12.58184.43NoYes1197
39A:A:Q227 B:B:G144 21.76614.93NoNo098
40B:B:D83 B:B:R68 14.182816.68YesNo085
41B:B:R68 B:B:Y85 14.500621.61NoNo054
42B:B:Y85 G:G:F61 14.74827.22NoYes148
43B:B:S84 G:G:F61 17.81766.61NoYes058
44B:B:S84 B:B:W63 18.13394.94NoYes057
45B:B:M61 B:B:W63 26.62594.65YesYes067
46B:B:C317 B:B:M61 35.55594.86NoYes076
47B:B:C317 B:B:S316 35.86045.16NoNo079
48B:B:S316 B:B:W332 36.16686.18NoYes099
49B:B:R314 B:B:W332 49.006529.99YesYes189
50B:B:W332 B:B:Y59 24.71036.75YesYes198
51B:B:M101 B:B:Y59 19.414710.78YesYes198
52A:A:F246 A:A:F273 35.40226.43NoYes099
53A:A:F273 A:A:F345 16.19059.65YesYes098
54A:A:G52 A:A:N292 16.87483.39NoNo099
55A:A:G52 A:A:K293 12.19451.74NoNo099
56A:A:L270 A:A:Q267 15.316.65NoYes064
57A:A:F312 A:A:Q267 10.06314.68YesYes084
58A:A:K280 A:A:W281 22.719622.05NoYes055
59A:A:K280 A:A:R283 22.19223.71NoNo053
60A:A:R283 A:A:R356 21.66496.4NoYes032
61A:A:H357 A:A:R356 19.61656.77NoYes072
62A:A:H357 A:A:W277 19.281528.56NoYes076
63A:A:S349 A:A:W277 20.85418.65YesYes476
64A:A:W281 B:B:D290 20.267610.05YesYes156
65A:A:L346 A:A:S349 24.78354.5NoYes447
66A:A:L346 A:A:R342 23.64714.86NoYes444
67A:A:R342 A:A:Y339 15.16410.29YesYes443
68A:A:K338 A:A:Y339 11.69428.36YesYes453
69A:A:F363 A:A:R342 12.55789.62NoYes454
70A:A:F363 A:A:K338 11.661514.89NoYes455
71A:A:E330 A:A:K338 16.170313.5YesYes435
72A:A:H387 A:A:I383 30.32913.98YesNo588
73A:A:Q384 R:R:I310 10.53134.12NoYes068
74A:A:H387 R:R:L309 30.279220.57YesNo088
75B:B:R314 B:B:T274 53.41429.06YesNo188
76B:B:S275 B:B:T274 86.77454.8NoNo088
77B:B:G288 B:B:S275 87.29843.71NoNo078
78B:B:C294 B:B:G288 87.47433.92NoNo057
79B:B:C294 B:B:L308 87.67357.94NoYes057
80B:B:L308 B:B:W339 90.676218.22YesYes079
81B:B:T329 B:B:W339 45.1210.92NoYes089
82B:B:H311 B:B:T329 45.174410.95YesNo098
83B:B:D333 B:B:H311 90.38327.56YesYes1399
84B:B:D312 B:B:D333 90.99911.98NoYes059
85B:B:D312 R:R:R214 90.961811.91NoNo057
86R:R:E469 R:R:R214 90.924716.28NoNo097
87R:R:E469 R:R:L215 89.79223.98NoYes1499
88R:R:L215 R:R:N220 43.90694.12YesYes1499
89R:R:N220 R:R:R219 43.746413.26YesYes1499
90A:A:Y391 R:R:R219 10.155211.32NoYes049
91B:B:K337 B:B:W339 45.66539.28YesYes1369
92B:B:H311 B:B:K337 45.465410.48YesYes1396
93R:R:E465 R:R:L215 46.72215.3YesYes1499
94R:R:E465 R:R:R219 44.22695.82YesYes1499
95R:R:L309 R:R:Y305 30.29315.24NoYes088
96B:B:G162 B:B:Y145 23.561410.14NoYes198
97B:B:G162 B:B:S161 23.76673.71NoNo199
98B:B:H142 B:B:S161 23.0615.34YesNo199
99B:B:H142 B:B:W169 42.46947.41YesYes198
100B:B:L139 B:B:W169 41.952520.5NoYes098
101B:B:C121 B:B:L139 38.63956.35NoNo089
102B:B:C121 B:B:C149 38.47933.64NoNo088
103B:B:C149 B:B:T102 38.3198.45NoNo088
104B:B:C148 B:B:T102 38.15843.38NoNo068
105B:B:C148 B:B:S160 37.67523.44NoYes066
106B:B:S160 B:B:V187 17.29944.85YesNo069
107B:B:H183 B:B:V187 17.12525.54YesNo099
108B:B:H183 B:B:K209 15.903420.96YesYes796
109B:B:C218 B:B:K209 15.16876.47NoYes756
110B:B:C218 G:G:Q18 30.14777.63NoNo059
111G:G:M21 G:G:Q18 29.79862.72NoNo019
112B:B:M217 G:G:M21 29.43485.78NoNo031
113B:B:E215 B:B:M217 29.07072.71NoNo033
114B:B:D212 B:B:E215 28.706415.59YesNo093
115B:B:D212 B:B:L198 26.88175.43YesNo093
116B:B:L198 B:B:L210 26.51619.69NoYes035
117B:B:L210 B:B:Q220 11.98943.99YesYes357
118B:B:D258 B:B:Q220 10.186813.05YesYes377
119B:B:L190 B:B:S160 20.05947.51NoYes056
120B:B:F199 B:B:L190 16.94018.53YesNo795
121B:B:F199 B:B:W211 15.339316.04YesYes798
122B:B:C218 B:B:W211 15.3425.22NoYes758
123B:B:C271 B:B:D290 37.01434.67NoYes056
124B:B:C271 B:B:Y289 35.05024.03NoYes057
125B:B:W297 B:B:Y289 29.853410.61YesYes1087
126B:B:W297 B:B:Y264 29.117814.47YesYes085
127B:B:M262 B:B:Y264 11.35664.79YesYes045
128B:B:L252 B:B:Y264 17.02597.03NoYes075
129B:B:D83 B:B:L69 16.70934.07YesNo085
130B:B:L69 B:B:V90 15.83774.47NoNo055
131B:B:H91 B:B:V90 11.88128.3NoNo655
132B:B:H91 B:B:V133 11.44734.15NoNo654
133B:B:D163 B:B:G144 21.61715.03YesNo098
134B:B:F278 B:B:L252 16.32933.65YesNo077
135B:B:F235 B:B:F278 10.63112.86YesYes967
136R:R:H223 R:R:R219 77.8246.77NoYes099
137R:R:E302 R:R:H223 77.637614.77YesNo099
138R:R:E302 R:R:L226 1009.28YesNo099
139R:R:F230 R:R:L226 87.22426.09YesNo289
140R:R:F230 R:R:N295 75.91421.75YesNo088
141R:R:N295 R:R:R233 76.207414.46NoYes088
142R:R:L292 R:R:R233 43.03189.72NoYes268
143L:L:I5 R:R:L292 44.05274.28YesNo206
144L:L:V2 R:R:Y296 14.81193.79YesYes207
145R:R:F230 R:R:Q451 12.485710.54YesYes289
146R:R:Q451 R:R:Y421 20.32899.02YesYes298
147R:R:Y296 R:R:Y421 15.084216.88YesYes278
148R:R:I299 R:R:L226 12.57665.71YesNo299
149R:R:I299 R:R:Q451 16.71914.12YesYes299
150L:L:V2 R:R:Q364 10.0698.6YesYes207
151L:L:E4 R:R:R233 16.47074.65YesYes208
152R:R:R233 R:R:Y195 12.95689.26YesYes287
153L:L:E4 R:R:M445 11.54479.47YesYes206
154L:L:H9 L:L:I5 38.9796.63YesYes200
155R:R:Q364 R:R:Y429 10.32824.51YesYes276
156L:L:H9 R:R:S355 35.22778.37YesNo007
157L:L:K13 R:R:S355 34.91311.53NoNo007
158L:L:K13 R:R:V31 34.59841.52NoYes006
159L:L:D17 R:R:V31 32.70524.38NoYes006
160L:L:D17 L:L:R20 32.38917.87NoYes000
161L:L:R20 R:R:D137 24.591810.72YesYes005
162L:L:L24 R:R:D137 23.00454.07NoYes005
163L:L:L24 R:R:F138 22.36819.74NoYes004
164R:R:F138 R:R:P132 18.49095.78YesYes1749
165R:R:L116 R:R:P132 18.29779.85NoYes059
166R:R:I115 R:R:L116 17.9714.28NoNo055
167R:R:I115 R:R:Y167 17.316616.92NoYes055
168R:R:I222 R:R:Y305 24.10188.46NoYes098
169R:R:E302 R:R:I222 24.05758.2YesNo099
170B:B:M101 B:B:Y145 19.92818.38YesYes198
171B:B:D163 B:B:H142 20.642410.08YesYes199
172A:A:W281 B:B:R314 11.627928.99YesYes158
173B:B:D290 B:B:T274 33.23727.23YesNo168
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:V2 R:R:Y296 3.79 2 Yes Yes 0 7 0 1
L:L:V2 R:R:Q364 8.6 2 Yes Yes 0 7 0 1
L:L:V2 R:R:I367 4.61 2 Yes No 0 7 0 1
L:L:A3 R:R:E444 6.03 0 No Yes 0 7 0 1
L:L:E4 R:R:Y195 12.35 2 Yes Yes 0 7 0 1
L:L:E4 R:R:R233 4.65 2 Yes Yes 0 8 0 1
L:L:E4 R:R:I237 4.1 2 Yes Yes 0 7 0 1
L:L:E4 R:R:M445 9.47 2 Yes Yes 0 6 0 1
L:L:I5 R:R:L289 5.71 2 Yes Yes 0 7 0 1
L:L:I5 R:R:L292 4.28 2 Yes No 0 6 0 1
L:L:I5 R:R:Q364 12.35 2 Yes Yes 0 7 0 1
L:L:Q6 R:R:Y429 29.31 2 Yes Yes 0 6 0 1
L:L:Q6 R:R:M441 5.44 2 Yes Yes 0 6 0 1
L:L:L7 R:R:L187 4.15 2 No Yes 0 5 0 1
L:L:L7 R:R:M441 5.65 2 No Yes 0 6 0 1
L:L:L7 R:R:M445 5.65 2 No Yes 0 6 0 1
L:L:M8 R:R:K240 11.52 2 Yes No 0 7 0 1
L:L:M8 R:R:F288 6.22 2 Yes Yes 0 7 0 1
L:L:M8 R:R:D353 8.32 2 Yes Yes 0 5 0 1
L:L:H9 R:R:S355 8.37 2 Yes No 0 7 0 1
L:L:H9 R:R:K360 7.86 2 Yes No 0 7 0 1
L:L:H9 R:R:Y429 14.16 2 Yes Yes 0 6 0 1
L:L:Q10 R:R:Y429 4.51 2 Yes Yes 0 6 0 1
L:L:Q10 R:R:V432 5.73 2 Yes Yes 0 5 0 1
L:L:Q10 R:R:W437 6.57 2 Yes Yes 0 5 0 1
L:L:R11 R:R:F184 17.1 2 No Yes 0 6 0 1
L:L:R11 R:R:Y245 20.58 2 No Yes 0 4 0 1
L:L:A12 R:R:D353 6.18 0 No Yes 0 5 0 1
L:L:W14 R:R:R181 4 2 Yes No 0 3 0 1
L:L:W14 R:R:F184 12.03 2 Yes Yes 0 6 0 1
L:L:Q16 R:R:V31 8.6 26 No Yes 0 6 0 1
L:L:Q16 R:R:T33 4.25 26 No No 0 7 0 1
L:L:Q16 R:R:L354 6.65 26 No No 0 5 0 1
L:L:D17 R:R:V31 4.38 0 No Yes 0 6 0 1
L:L:R20 R:R:Y136 11.32 0 Yes No 0 4 0 1
L:L:R20 R:R:D137 10.72 0 Yes Yes 0 5 0 1
L:L:R21 R:R:D137 13.1 0 No Yes 0 5 0 1
L:L:F23 R:R:K34 22.33 27 No No 0 4 0 1
L:L:F23 R:R:I38 5.02 27 No No 0 7 0 1
L:L:L24 R:R:D137 4.07 0 No Yes 0 5 0 1
L:L:L24 R:R:F138 9.74 0 No Yes 0 4 0 1
L:L:H25 R:R:L174 3.86 0 No No 0 3 0 1
L:L:I31 R:R:I115 5.89 0 No No 0 5 0 1
L:L:H32 R:R:N166 3.83 0 No No 0 7 0 1
L:L:H32 R:R:Y167 7.62 0 No Yes 0 5 0 1
R:R:L354 R:R:V31 4.47 26 No Yes 5 6 1 1
R:R:M32 R:R:Y136 8.38 0 No No 6 4 2 1
R:R:E36 R:R:T33 11.29 0 No No 6 7 2 1
R:R:I38 R:R:K34 4.36 27 No No 7 4 1 1
R:R:D113 R:R:W118 11.17 18 No Yes 9 9 2 2
R:R:D113 R:R:Y167 8.05 18 No Yes 9 5 2 1
R:R:I115 R:R:L116 4.28 0 No No 5 5 1 2
R:R:I115 R:R:Y167 16.92 0 No Yes 5 5 1 1
R:R:L116 R:R:P132 9.85 0 No Yes 5 9 2 2
R:R:W118 R:R:Y167 3.86 18 Yes Yes 9 5 2 1
R:R:I135 R:R:P132 5.08 17 Yes Yes 7 9 2 2
R:R:F138 R:R:P132 5.78 17 Yes Yes 4 9 1 2
R:R:F138 R:R:I135 17.58 17 Yes Yes 4 7 1 2
R:R:C170 R:R:F138 11.17 0 No Yes 9 4 2 1
R:R:A144 R:R:Y167 4 0 No Yes 7 5 2 1
R:R:N166 R:R:Y145 5.81 0 No Yes 7 4 1 2
R:R:A165 R:R:Y167 5.34 0 No Yes 7 5 2 1
R:R:N166 R:R:S168 8.94 0 No No 7 6 1 2
R:R:L174 R:R:V171 5.96 0 No No 3 3 1 2
R:R:R181 R:R:T178 7.76 0 No No 3 3 1 2
R:R:E180 R:R:V432 4.28 2 Yes Yes 3 5 2 1
R:R:F184 R:R:V432 6.55 2 Yes Yes 6 5 1 1
R:R:F184 R:R:W437 6.01 2 Yes Yes 6 5 1 1
R:R:L187 R:R:M441 5.65 2 Yes Yes 5 6 1 1
R:R:H442 R:R:L187 6.43 0 No Yes 5 5 2 1
R:R:L187 R:R:M445 4.24 2 Yes Yes 5 6 1 1
R:R:Y191 R:R:Y195 5.96 2 Yes Yes 7 7 2 1
R:R:I237 R:R:Y191 4.84 2 Yes Yes 7 7 1 2
R:R:M445 R:R:Y191 11.97 2 Yes Yes 6 7 1 2
R:R:R233 R:R:Y195 9.26 2 Yes Yes 8 7 1 1
R:R:A234 R:R:Y195 4 0 No Yes 8 7 2 1
R:R:I237 R:R:Y195 7.25 2 Yes Yes 7 7 1 1
R:R:S449 R:R:Y195 7.63 2 No Yes 9 7 2 1
R:R:L292 R:R:R233 9.72 2 No Yes 6 8 1 1
R:R:N295 R:R:R233 14.46 0 No Yes 8 8 2 1
R:R:R233 R:R:Y296 13.38 2 Yes Yes 8 7 1 1
R:R:R233 R:R:Y421 5.14 2 Yes Yes 8 8 1 2
R:R:F288 R:R:I237 5.02 2 Yes Yes 7 7 1 1
R:R:K240 R:R:L244 4.23 2 No Yes 7 5 1 2
R:R:F288 R:R:K240 17.37 2 Yes No 7 7 1 1
R:R:L244 R:R:Y245 10.55 2 Yes Yes 5 4 2 1
R:R:D353 R:R:L244 12.21 2 Yes Yes 5 5 1 2
R:R:D353 R:R:Y245 9.2 2 Yes Yes 5 4 1 1
R:R:F288 R:R:L289 6.09 2 Yes Yes 7 7 1 1
R:R:L289 R:R:W339 5.69 2 Yes Yes 7 8 1 2
R:R:I363 R:R:L289 7.14 2 No Yes 7 7 2 1
R:R:L292 R:R:Y296 5.86 2 No Yes 6 7 1 1
R:R:I367 R:R:Y296 9.67 2 No Yes 7 7 1 1
R:R:I371 R:R:Y296 4.84 2 No Yes 7 7 2 1
R:R:Y296 R:R:Y421 16.88 2 Yes Yes 7 8 1 2
R:R:F335 R:R:I363 5.02 2 Yes No 5 7 2 2
R:R:F335 R:R:I367 5.02 2 Yes No 5 7 2 1
R:R:I363 R:R:W339 14.09 2 No Yes 7 8 2 2
R:R:K360 R:R:W361 12.76 2 No No 7 8 1 2
R:R:K360 R:R:Y429 19.11 2 No Yes 7 6 1 1
R:R:Q364 R:R:W361 10.95 2 Yes No 7 8 1 2
R:R:Q364 R:R:Y429 4.51 2 Yes Yes 7 6 1 1
R:R:L368 R:R:M425 9.9 0 No No 4 6 1 2
R:R:I371 R:R:Y421 6.04 2 No Yes 7 8 2 2
R:R:N448 R:R:Y421 15.12 2 No Yes 6 8 2 2
R:R:F424 R:R:Y443 7.22 2 Yes Yes 7 4 2 2
R:R:E444 R:R:F424 7 2 Yes Yes 7 7 1 2
R:R:T430 R:R:W437 6.06 0 No Yes 5 5 2 1
R:R:V432 R:R:W437 19.61 2 Yes Yes 5 5 1 1
R:R:M441 R:R:W437 22.1 2 Yes Yes 6 5 1 1
R:R:E444 R:R:Y443 4.49 2 Yes Yes 7 4 1 2
R:R:E444 R:R:N448 13.15 2 Yes No 7 6 1 2
R:R:D241 R:R:Y245 3.45 0 No Yes 8 4 2 1
L:L:M8 R:R:V285 3.04 2 Yes No 0 6 0 1
L:L:V2 R:R:L368 2.98 2 Yes No 0 4 0 1
R:R:I190 R:R:M445 2.92 0 No Yes 6 6 2 1
R:R:D137 R:R:L174 2.71 0 Yes No 5 3 1 1
R:R:H42 R:R:I38 2.65 0 No No 4 7 2 1
L:L:K13 R:R:S355 1.53 0 No No 0 7 0 1
L:L:K13 R:R:V31 1.52 0 No Yes 0 6 0 1
L:L:R20 R:R:K34 1.24 0 Yes No 0 4 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
82.76Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
80.00Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
80.00Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
80.00Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
79.31Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
78.57Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
76.67Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
71.43Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
71.43Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
68.97Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
68.97Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
66.67Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
66.67Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
66.67Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
65.52Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
64.52Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
64.29Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
62.86Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
62.50Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
62.07Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
61.29Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
61.29Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
60.00Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
60.00Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
58.06Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
58.06Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
57.69Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
56.67Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
56.67Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
56.67Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
56.25Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
56.25Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
54.84Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
54.84Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
54.84Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
54.84Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
54.84Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
53.33Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
53.12Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
53.12Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
53.12Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
53.12Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
51.72Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
51.61Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
51.61Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
51.43Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
50.00Single6FJ3PTH6FJ3-PTH1-PTH
50.00Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
50.00Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
50.00Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
50.00Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
50.00Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
48.39Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
48.39Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
48.39Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
48.39Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
48.39Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
47.22Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
47.22Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
47.06Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
46.88Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
45.16Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
45.16Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
44.74Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
44.44Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
44.44Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
44.12Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
44.12Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
44.12Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
43.75Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
43.75Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
42.86Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
42.86Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
42.86Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
42.86Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
42.11Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
41.67Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
41.46Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
41.38Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
40.62Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
40.54Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
40.00Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
40.00Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
39.47Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
38.89Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
38.89Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
38.71Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
38.46Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
38.24Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
38.24Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
37.93Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
37.93Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
37.84Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
37.50Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
37.21Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
36.84Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
36.67Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
36.11Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
36.11Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
35.71Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
35.48Single5EE7MK08935EE7-Glucagon-MK0893
35.29Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
35.29Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
35.14Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
35.00Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
34.48Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
34.48Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
34.48Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
34.38Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
33.33Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
33.33Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
33.33Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
33.33Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
32.26Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
32.26Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
31.43Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
31.25Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
31.25Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
31.25Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
31.03Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
31.03Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
31.03Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
30.30Single7QA8Peptide7QA8-STE2-Peptide
30.30Single7QA8Peptide7QA8-STE2-Peptide
30.30Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
30.00Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
30.00Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
30.00Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
29.73Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
29.73Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
29.41Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
29.41Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
29.03Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
29.03Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
29.03Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
29.03Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
29.03Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
29.03Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
29.03Consensuslpl_offOrthosteric Ligands1p_off lpa_off
29.03Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
29.03Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
28.95Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
28.95Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
28.95Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
28.95Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
28.95Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
28.95Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
28.95Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
28.57Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
28.57Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
28.57Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
28.57Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
28.57Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
28.21Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
28.21Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
28.12Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
28.12Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
28.12Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
28.12Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
28.12Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
28.12Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
28.12Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
27.78Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
27.78Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
27.78Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
27.78Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
27.78Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
27.59Single7V3ZCP559407V3Z-CB1-CP55940
27.59Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
27.59Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
27.50Single6IGKEndothelin-36IGK-ETB-Endothelin-3
27.50Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
27.50Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
27.50Consensusbombesin_onOrthosteric Ligandbb2_on
27.50Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
27.50Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
27.50Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
27.27Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
27.27Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
27.27Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
27.27Single8QJ2pN1628QJ2-MC4-pN162-Gs
27.27Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
27.27Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
27.27Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
27.03Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
27.03Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
27.03Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
27.03Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
27.03Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
27.03Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
27.03Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
27.03Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
26.67Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
26.67Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
26.67Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
26.67Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
26.67Single8TF5Oleic acid8TF5-GPR6-Oleic acid
26.67Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
26.67Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
26.67Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
26.67Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
26.47Single4XT1Fractalkine4XT1-US28-Fractalkine
26.47Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
26.47Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
26.47Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
26.47Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
26.47Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
26.47Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
26.47Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
26.47Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
26.32Single4XT3Fractalkine4XT3-US28-Fractalkine
26.32Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
26.32Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
26.32Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
26.32Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
26.32Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
26.32Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
25.81Single5XR8AM8415XR8-CB1-AM841
25.81Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
25.81Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
25.81Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
25.81Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
25.81Single8E0GBU728E0G-μ-BU72
25.81Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
25.81Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
25.81Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
25.81Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
25.81Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
25.71Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
25.71Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
25.71Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
25.71Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
25.71Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
25.71Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
25.71Single7XNACYN1548067XNA-SST2-CYN154806
25.71Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
25.71Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
25.71Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
25.71Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
25.71Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
25.71Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
25.71Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
25.71Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
25.64Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
25.64Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
25.64Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
25.64Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
25.00Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
25.00Single6KQICP559406KQI-CB1-CP55940-Org27569
25.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
25.00Single7DFPSpiperone7DFP-D2-Spiperone
25.00Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
25.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
25.00Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
25.00Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
25.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
25.00Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
25.00Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
25.00Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.00Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
25.00Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.00Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.00Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
25.00Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
25.00Consensusangiotensin_onOrthosteric Ligandat1_on
25.00Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
25.00Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
25.00Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
25.00Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
25.00Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
25.00Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
25.00Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
25.00Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
25.00Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
25.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
25.00Consensuslpa_offOrthosteric Ligandlpa1_off
25.00Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
25.00Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
25.00Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
25.00Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
24.39Single5GLHEndothelin-15GLH-ETB-Endothelin-1
24.39Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
24.39Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
24.39Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
24.32Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
24.32Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
24.32Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
24.32Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
24.32Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
24.32Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
24.32Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
24.32Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
24.32Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
24.32Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
24.32Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
24.32Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
24.32Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
24.32Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
24.32Consensusvasop-oxy_onOrthosteric Ligandv2_on
24.32Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
24.24Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
24.24Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
24.24Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
24.24Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
24.24Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
24.24Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
24.24Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
24.24Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
24.24Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
24.14Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
24.14Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
24.14Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
24.14Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
24.14Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
24.14Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
24.14Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
24.14Single8K5CAcipimox8K5C-HCA2-Acipimox
24.14Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
24.14Consensushca_onOrthosteric Ligandhca2_on
23.68Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
23.68Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
23.68Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
23.68Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
23.68Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
23.68Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
23.68Single8ZRTET-18ZRT-ETB-ET-1
23.68Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
23.68Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
23.68Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
23.68Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
23.68Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
23.68Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
23.68Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
23.53Single3NY9ICI118-5513NY9-β2-ICI118-551
23.53Single4UG2CGS216804UG2-A2A-CGS21680
23.53Single5ZTYAM102575ZTY-CB2-AM10257
23.53Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
23.53Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
23.53Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
23.53Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
23.53Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
23.53Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
23.53Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
23.53Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
23.53Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
23.53Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
23.33Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
23.33Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
23.33Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
23.33Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
23.33Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
23.33Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
23.33Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
23.33Single9B9ZA1AKO9B9Z-CB1-A1AKO
23.33Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
23.33Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
23.33Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
23.33Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
23.33Consensushca_on_gpOrthosteric Ligandhca2_on_gp
23.33Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
23.26Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
23.26Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
23.08Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
23.08Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
23.08Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
23.08Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
22.86Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
22.86Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
22.86Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
22.86Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
22.86Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.86Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
22.86Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
22.86Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
22.86Consensuslpl_onOrthosteric Ligands1p_on lpa_on
22.86Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
22.86Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
22.86Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
22.86Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
22.86Consensussomatostatin_offOrthosteric Ligandsst2_off
22.86Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
22.73Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
22.58Single5C1MBU725C1M-μ-BU72
22.58Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
22.58Single7C4SS1P7C4S-S1P3-S1P
22.58Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
22.58Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
22.58Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
22.58Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.58Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
22.58Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
22.58Single8JXSPF-61428JXS-D1-PF-6142
22.58Single8S4DCMF-0198S4D-Apelin-CMF-019
22.58Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
22.58Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
22.58Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
22.58Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
22.58Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
22.50Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
22.50Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
22.50Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
22.50Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
22.50Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
22.50Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
22.22Single3QAKUK-4320973QAK-A2A-UK-432097
22.22Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
22.22Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
22.22Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
22.22Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
22.22Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.22Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.22Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
22.22Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
22.22Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
22.22Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
22.22Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
22.22Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
21.95Single6IGLIRL16206IGL-ETB-IRL1620
21.95Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
21.88Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
21.88Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
21.88Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
21.88Single5XRAAM115425XRA-CB1-AM11542
21.88Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
21.88Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
21.88Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
21.88Single7FEECP559407FEE-CB1-CP55940-ZCZ011
21.88Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
21.88Single7TUYGSK682753A7TUY-GPR183-GSK682753A
21.88Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
21.88Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
21.88Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
21.88Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
21.88Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
21.88Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
21.88Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
21.88Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
21.88Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.88Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
21.88Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
21.88Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
21.88Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
21.88Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
21.88Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.88Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
21.88Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
21.88Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
21.88Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
21.88Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.88Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
21.88Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
21.88Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
21.74Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
21.74Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
21.62Single3OE0CVX153OE0-CXCR4-CVX15
21.62Single5WF5UK-4320975WF5-A2A-UK-432097
21.62Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
21.62Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
21.62Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
21.62Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
21.62Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
21.62Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
21.62Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
21.62Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
21.62Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
21.62Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
21.62Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
21.43Single3OE9IT1t3OE9-CXCR4-IT1t
21.43Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
21.43Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
21.43Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
21.43Single8K5BNiacin8K5B-HCA2-Niacin
21.43Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
21.43Single9B9Y7DY9B9Y-CB1-7DY
21.43Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
21.43Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
21.21Single4N4WSANT-14N4W-SMO-SANT-1
21.21Single4XEENeurotensin4XEE-NTS1-Neurotensin
21.21Single4XESNeurotensin4XES-NTS1-Neurotensin
21.21Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
21.21Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
21.21Single6A93Risperidone6A93-5-HT2A-Risperidone
21.21Single6OS2TRV0266OS2-AT1-TRV026
21.21Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
21.21Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
21.21Single6YVRNTS8-136YVR-NTS1-NTS8-13
21.21Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
21.21Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
21.21Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
21.21Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
21.21Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
21.21Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
21.21Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
21.21Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
21.21Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
21.21Single7YITNalfurafine7YIT-κ-Nalfurafine
21.21Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
21.21Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
21.21Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
21.21Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
21.21Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
21.21Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
21.21Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
21.21Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
21.21Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
21.21Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
21.21Single8XYIVUF106618XYI-CXCR3-VUF10661
21.21Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
21.21Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
21.21Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
21.21Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
21.21Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
21.21Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
21.21Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
21.21Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
21.21Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
21.21Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
21.21Consensusorexin_onOrthosteric Ligandox2_on
21.05Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
21.05Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
21.05Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
21.05Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
21.05Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
21.05Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
21.05Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.05Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
21.05Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
21.05Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
21.05Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
21.05Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
21.05Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
21.05Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
20.93Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
20.93Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
20.69Single5U09Taranabant5U09-CB1-Taranabant
20.69Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
20.69Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
20.69Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
20.69Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
20.69Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
20.69Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
20.69Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.69Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
20.69Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
20.69Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
20.69Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
20.69Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
20.69Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
20.69Single9BA0A1AKN9BA0-CB1-A1AKN
20.69Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
20.69Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
20.69Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
20.69Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
20.69Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
20.59Single4BUONeurotensin4BUO-NTS1-Neurotensin
20.59Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
20.59Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
20.59Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
20.59Single5X93K-87945X93-ETB-K-8794
20.59Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
20.59Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
20.59Single7EZCUKA7EZC-A2A-UKA
20.59Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
20.59Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
20.59Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
20.59Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
20.59Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.59Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
20.59Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
20.59Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
20.59Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
20.59Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
20.59Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
20.59Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.59Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
20.59Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
20.59Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
20.59Consensuscck_onOrthosteric Ligandccka_on cckb_on
20.59Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
20.59Consensusendothelin_offOrthosteric Ligandetb_off
20.59Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
20.59Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.59Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.59Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
20.59Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
20.59Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
20.59Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
20.59Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
20.59Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
20.59Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
20.59Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
20.59Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
20.51Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
20.51Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
20.51Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
20.51Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
20.51Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
20.51Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
20.51Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
20.00Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
20.00Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
20.00Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
20.00Single7SK3CXCL127SK3-ACKR3-CXCL12
20.00Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
20.00Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single7T32ZM-2413857T32-A2A-ZM-241385
20.00Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
20.00Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
20.00Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
20.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8IHKAcifran8IHK-HCA3-Acifran
20.00Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
20.00Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
20.00Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
20.00Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
20.00Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
20.00Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.00Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
20.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
20.00Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
20.00Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
20.00Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
20.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
20.00Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
20.00Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
20.00Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
20.00Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
20.00Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
20.00Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
20.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
20.00Consensusgrh_offOrthosteric Ligandgnrh1_off
19.51Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
19.44Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
19.44Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
19.44Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
19.44Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
19.44Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
19.44Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
19.44Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
19.44Single8IEBA1LYA8IEB-GPR156-A1LYA
19.44Single8IEIA1LYA8IEI-GPR156-A1LYA
19.44Single8IEPA1LYA8IEP-GPR156-A1LYA
19.44Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
19.44Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
19.44Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
19.44Single8WDTphotoNECA8WDT-A2A-photoNECA
19.44Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.44Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
19.44Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
19.44Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
19.44Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
19.44Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
19.35Single2Y04Salbutamol2Y04-β1-Salbutamol
19.35Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
19.35Single4YAYZD-71554YAY-AT1-ZD-7155
19.35Single5TGZAM65385TGZ-CB1-AM6538
19.35Single5UENDU1725UEN-A1-DU172
19.35Single6GPSMK08126GPS-CCR2-MK0812
19.35Single6PS1Timolol6PS1-β2-Timolol
19.35Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
19.35Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
19.35Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
19.35Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
19.35Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
19.35Single7UL4Alvimopan7UL4-μ-Alvimopan
19.35Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
19.35Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
19.35Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
19.35Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
19.35Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
19.35Single7YXAONO-54306087YXA-S1P5-ONO-5430608
19.35Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
19.35Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
19.35Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
19.35Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
19.35Single8K5DGSK2560738K5D-HCA2-GSK256073
19.35Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
19.35Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
19.35Single8T1WCVN4248T1W-GPR6-CVN424
19.35Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
19.35Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.35Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.35Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
19.35Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
19.35Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
19.35Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
19.35Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
19.35Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
19.35Single9CHXS-Carazolol9CHX-β2-S-Carazolol
19.35Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
19.35Consensusa3_onOrthosteric Liganda3a_on
19.35Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
19.35Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
19.35Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
19.35Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
19.23Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
19.23Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
19.05Single8IY6Endothelin-18IY6-ETB-Endothelin-1
19.05Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
19.05Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
19.05Consensusbradykinin_onOrthosteric Ligandbk2_on
19.05Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
19.05Consensusendothelin_onOrthosteric Ligandetb_on eta_on
19.05Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
19.05Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
18.92Single6HLOAprepitant6HLO-NK1-Aprepitant
18.92Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
18.92Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
18.92Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
18.92Single7SK5CXCL127SK5-ACKR3-CXCL12
18.92Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
18.92Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
18.92Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
18.92Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
18.92Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
18.92Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
18.92Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
18.75Single2Y03Isoprenaline2Y03-β1-Isoprenaline
18.75Single4JKVTaladegib4JKV-SMO-Taladegib
18.75Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
18.75Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
18.75Single5JQHS-Carazolol5JQH-β2-S-Carazolol
18.75Single5N2RPSB-365N2R-A2A-PSB-36-Na
18.75Single5N2SPSB365N2S-A1-PSB36
18.75Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
18.75Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
18.75Single5TVNLSD5TVN-5-HT2B-LSD
18.75Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
18.75Single6D26Fevipiprant6D26-DP2-Fevipiprant
18.75Single6GPXMK08126GPX-CCR2-MK0812
18.75Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
18.75Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
18.75Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
18.75Single6PS6Timolol6PS6-β2-Timolol
18.75Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
18.75Single7C61Ergotamine7C61-5-HT1B-Ergotamine
18.75Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
18.75Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
18.75Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
18.75Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
18.75Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
18.75Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
18.75Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
18.75Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
18.75Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
18.75Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
18.75Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.75Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
18.75Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
18.75Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
18.75Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
18.75Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.75Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
18.75Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
18.75Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
18.75Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
18.75Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
18.75Single8QOTNanobody-E8QOT-μ-Nanobody-E
18.75Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
18.75Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.75Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
18.75Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
18.75Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
18.75Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
18.75Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
18.75Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
18.75Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
18.75Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
18.75Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
18.75Consensusa3_on_gpOrthosteric Liganda3a_on_gp
18.75Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
18.75Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
18.75Consensusadenosine_offOrthosteric Liganda1_off a2_off
18.75Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
18.75Consensusblt_offOrthosteric Ligandblt1_off
18.75Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
18.75Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
18.75Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
18.75Consensusdp_offOrthosteric Liganddp2_off
18.75Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
18.75Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
18.75Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
18.75Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
18.75Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.75Consensustrace-amine_onOrthosteric Ligandta1_on
18.60Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
18.60Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
18.52Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
18.42Single6PT2KGCHM076PT2-δ-KGCHM07
18.42Single6W25SHU91196W25-MC4-SHU9119-Ca
18.42Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
18.42Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
18.42Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
18.42Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
18.42Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
18.18Single2YDVNECA2YDV-A2A-NECA
18.18Single3P0GBI1671073P0G-β2-BI167107
18.18Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
18.18Single4BV0Neurotensin4BV0-NTS1-Neurotensin
18.18Single4DJHJDTic4DJH-κ-JDTic
18.18Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
18.18Single4UHRCGS216804UHR-A2A-CGS21680
18.18Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
18.18Single5G53NECA5G53-A2A-NECA-Gs
18.18Single5V54Methiothepin5V54-5-HT1B-Methiothepin
18.18Single5V56TC1145V56-SMO-TC114
18.18Single5V57TC1145V57-SMO-TC114
18.18Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
18.18Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
18.18Single6H7JIsoprenaline6H7J-β1-Isoprenaline
18.18Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
18.18Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
18.18Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
18.18Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
18.18Single6TQ7SB-3348676TQ7-OX1-SB-334867
18.18Single6WGTLSD6WGT-5-HT2A-LSD
18.18Single7B6WCyclazosin7B6W-α1b-Cyclazosin
18.18Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
18.18Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
18.18Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
18.18Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
18.18Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
18.18Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
18.18Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
18.18Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
18.18Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
18.18Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
18.18Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
18.18Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
18.18Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
18.18Single8EA0Iperoxo8EA0-M3-Iperoxo
18.18Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
18.18Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
18.18Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
18.18Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
18.18Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
18.18Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
18.18Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
18.18Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
18.18Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
18.18Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
18.18Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
18.18Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
18.18Consensus5ht1_offOrthosteric Ligand5ht1b_off
18.18Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
18.18Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
18.18Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
18.18Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
18.18Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
18.18Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
18.18Consensuslpa_onOrthosteric Ligandlpa1_on
18.18Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
18.18Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
18.18Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Consensusneurotensin_onOrthosteric Ligandnts1_on
18.18Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
18.18Consensusrelaxin_onOrthosteric Ligandrxfp4_on
18.18Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
18.18Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.18Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
17.95Single6JODAngiotensin II6JOD-AT2-Angiotensin II
17.95Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
17.95Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
17.95Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
17.95Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
17.95Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
17.95Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
17.86Single3OE6IT1t3OE6-CXCR4-IT1t
17.86Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
17.86Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
17.86Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
17.86Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
17.86Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
17.65Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
17.65Single4LDEBI1671074LDE-β2-BI167107
17.65Single4RWADIPP-NH24RWA-δ-DIPP-NH2
17.65Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
17.65Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
17.65Single6CM4Risperidone6CM4-D2-Risperidone
17.65Single6IIURamatroban6IIU-TP-Ramatroban
17.65Single6MXTSalmeterol6MXT-β2-Salmeterol
17.65Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
17.65Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
17.65Single6ZG4HTL00099366ZG4-M1-HTL0009936
17.65Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
17.65Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
17.65Single7K15MKD0467K15-BLT1-MKD046-Na
17.65Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.65Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.65Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
17.65Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
17.65Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
17.65Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
17.65Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
17.65Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
17.65Single8JJ8Formoterol8JJ8-β2-Formoterol
17.65Single8JJLOlodaterol8JJL-β2-Olodaterol
17.65Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
17.65Single8JWY2-1188JWY-A2A-2-118
17.65Single8JWZAB9288JWZ-A2A-AB928-Na
17.65Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
17.65Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
17.65Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
17.65Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
17.65Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
17.65Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
17.65Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
17.65Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
17.65Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
17.65Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
17.65Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
17.65Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
17.65Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.65Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.50Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
17.50Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
17.50Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
17.50Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
17.50Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
17.50Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
17.50Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
17.24Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
17.24Single6LI0C176LI0-GPR52-C17
17.24Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
17.24Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
17.24Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
17.24Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
17.24Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.24Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
17.24Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
17.24Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.24Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
17.24Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
17.14Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
17.14Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
17.14Single5CGDHTL142425CGD-mGlu5-HTL14242
17.14Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
17.14Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
17.14Single6K1QIRL25006K1Q-ETB-IRL2500
17.14Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
17.14Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
17.14Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
17.14Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.14Single7UM4AS26747237UM4-5-HT5A-AS2674723
17.14Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
17.14Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
17.14Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
17.14Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
17.14Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
17.14Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
17.14Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
17.14Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
17.14Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
17.14Single8XVUCXCL28XVU-CXCR2-CXCL2
17.14Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
17.14Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
17.14Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
17.14Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
17.14Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
17.14Consensuschemerin_onOrthosteric Ligandcml1_on
17.14Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
17.14Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
17.14Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.14Consensusprostanoid_offOrthosteric Ligandep_off dp_off
17.07Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
17.07Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
17.07Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
16.67Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
16.67Single3ODUIT1t3ODU-CXCR4-IT1t
16.67Single4BWBNeurotensin4BWB-NTS1-Neurotensin
16.67Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
16.67Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
16.67Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
16.67Single5WF6UK-4320975WF6-A2A-UK-432097
16.67Single6AKXA4R6AKX-CCR5-A4R
16.67Single6AKYMaraviroc6AKY-CCR5-Maraviroc
16.67Single6B73MP11046B73-κ-MP1104
16.67Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
16.67Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
16.67Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
16.67Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
16.67Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
16.67Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
16.67Single6PT3DPI-2876PT3-δ-DPI-287
16.67Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
16.67Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
16.67Single7BR3Elagolix7BR3-GnRH1-Elagolix
16.67Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single7F8YDevazepide7F8Y-CCKA-Devazepide
16.67Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
16.67Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
16.67Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
16.67Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
16.67Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
16.67Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
16.67Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
16.67Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
16.67Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
16.67Single7XN9L-054,5227XN9-SST2-L-054,522
16.67Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
16.67Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
16.67Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
16.67Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
16.67Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
16.67Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
16.67Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
16.67Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
16.67Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
16.67Single8GNGIstradefylline8GNG-A2A-Istradefylline
16.67Single8IEIA1LYA8IEI-GPR156-A1LYA
16.67Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
16.67Single8IWESpermidine8IWE-TA9-Spermidine
16.67Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
16.67Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
16.67Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
16.67Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
16.67Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
16.67Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
16.67Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
16.67Single8X5YAstemizole8X5Y-H1-Astemizole
16.67Single8Y0HVUF114188Y0H-CXCR3-VUF11418
16.67Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
16.67Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
16.67Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
16.67Consensusalpha2_offOrthosteric Ligandalpha2c_off
16.67Consensusangiotensin_offOrthosteric Ligandat1_off
16.67Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
16.67Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
16.67Consensusorexin_offOrthosteric Ligandox2_off ox1_off
16.67Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
16.67Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
16.67Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
16.67Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
16.28Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
16.28Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
16.22Single4IARErgotamine4IAR-5-HT1B-Ergotamine
16.22Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
16.22Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
16.22Single7F8XNN90567F8X-CCKA-NN9056
16.22Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
16.22Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
16.22Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
16.22Single8IEPA1LYA8IEP-GPR156-A1LYA
16.22Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
16.22Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
16.22Single8WKYPG-9348WKY-MC4-PG-934
16.22Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
16.22Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
16.22Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
16.13Single2YDOAdenosine2YDO-A2A-Adenosine
16.13Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
16.13Single4MBSMaraviroc4MBS-CCR5-Maraviroc
16.13Single4ZJCSB-6740424ZJC-OX1-SB-674042
16.13Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
16.13Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
16.13Single5IU7Q274563465IU7-A2A-Q27456346-Na
16.13Single5IUBQ274563445IUB-A2A-Q27456344-Na
16.13Single5JTBZM-2413855JTB-A2A-ZM-241385
16.13Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
16.13Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
16.13Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
16.13Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
16.13Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
16.13Single6PS0S-Carazolol6PS0-β2-S-Carazolol
16.13Single6PS4ICI118-5516PS4-β2-ICI118-551
16.13Single6PS5S-Propranolol6PS5-β2-S-Propranolol
16.13Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
16.13Single6TPGEMPA6TPG-OX2-EMPA
16.13Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
16.13Single6V9SGTPL114036V9S-OX1-GTPL11403
16.13Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
16.13Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
16.13Single6ZG9GSK10347026ZG9-M1-GSK1034702
16.13Single7AROLUF58337ARO-A2A-LUF5833-Na
16.13Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
16.13Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
16.13Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
16.13Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
16.13Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
16.13Single7UL3Famotidine7UL3-H2-Famotidine
16.13Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
16.13Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
16.13Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
16.13Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
16.13Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
16.13Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
16.13Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
16.13Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
16.13Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
16.13Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
16.13Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
16.13Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.13Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.13Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
16.13Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
16.13Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
16.13Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
16.13Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
16.13Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
16.13Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
16.13Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
16.13Single8K2WAMG4878K2W-CXCR3-AMG487
16.13Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
16.13Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
16.13Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
16.13Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
16.13Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
16.13Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.13Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.13Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
16.13Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
16.13Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
16.13Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.13Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
16.13Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
16.13Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
16.13Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
16.13Consensusa2_offOrthosteric Liganda2a_off
16.13Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
16.13Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
16.13Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
16.13Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
16.13Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
16.13Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
16.13Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
15.91Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
15.79Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
15.79Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
15.79Single8IEBA1LYA8IEB-GPR156-A1LYA
15.79Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
15.79Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
15.79Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
15.79Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
15.79Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
15.62Single3EMLZM-2413853EML-A2A-ZM-241385
15.62Single3NY8ICI118-5513NY8-β2-ICI118-551
15.62Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
15.62Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
15.62Single4DAJTiotropium4DAJ-M3-Tiotropium
15.62Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
15.62Single4GBRS-Carazolol4GBR-β2-S-Carazolol
15.62Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
15.62Single4QKX35V4QKX-β2-35V
15.62Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
15.62Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
15.62Single5DHGC-355DHG-NOP-C-35
15.62Single5DHHSB-6121115DHH-NOP-SB-612111
15.62Single5IU8Q274563475IU8-A2A-Q27456347-Na
15.62Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
15.62Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
15.62Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
15.62Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
15.62Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
15.62Single5T04Neurotensin5T04-NTS1-Neurotensin
15.62Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
15.62Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
15.62Single6D27CAY104716D27-DP2-CAY10471
15.62Single6DRXLisuride6DRX-5-HT2B-Lisuride
15.62Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
15.62Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
15.62Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
15.62Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
15.62Single6H7MSalbutamol6H7M-β1-Salbutamol
15.62Single6IIVDaltroban6IIV-TP-Daltroban
15.62Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
15.62Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
15.62Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
15.62Single6S0LZM-2413856S0L-A2A-ZM-241385
15.62Single6TOTLemborexant6TOT-OX1-Lemborexant
15.62Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
15.62Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
15.62Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
15.62Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
15.62Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
15.62Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
15.62Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
15.62Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
15.62Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
15.62Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
15.62Single7PYRPSB-21157PYR-A2A-PSB-2115
15.62Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
15.62Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
15.62Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
15.62Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
15.62Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
15.62Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
15.62Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
15.62Single7WC7Lisuride7WC7-5-HT2A-Lisuride
15.62Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
15.62Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
15.62Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
15.62Single8CU6LJ-45178CU6-A2A-LJ-4517
15.62Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
15.62Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
15.62Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
15.62Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
15.62Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.62Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.62Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.62Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.62Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.62Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.62Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.62Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.62Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.62Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.62Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
15.62Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
15.62Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
15.62Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
15.62Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
15.62Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
15.62Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
15.62Single8JJOAlprenolol8JJO-β2-Alprenolol
15.62Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
15.62Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
15.62Single8JXRLSD8JXR-D1-LSD
15.62Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
15.62Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
15.62Single8RLNLUF58348RLN-A2A-LUF5834
15.62Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
15.62Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
15.62Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.62Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.62Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.62Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.62Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
15.62Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
15.62Single8X63Mepyramine8X63-H1-Mepyramine
15.62Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
15.62Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
15.62Consensus5ht5_onOrthosteric Ligand5ht5a_on
15.62Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
15.62Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
15.62Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
15.62Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
15.62Consensuscck_offOrthosteric Ligandccka_off
15.62Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
15.62Consensusdopamine_offOrthosteric Ligandd2_off d3_off
15.62Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
15.62Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
15.62Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
15.62Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
15.62Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
15.62Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
15.62Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
15.62Consensushistamine_offOrthosteric Ligandh1_off
15.56Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
15.56Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
15.38Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
15.38Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
15.38Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
15.38Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Single2RH1S-Carazolol2RH1-β2-S-Carazolol
15.15Single2YCWS-Carazolol2YCW-β1-S-Carazolol
15.15Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
15.15Single5CGCHTL142425CGC-mGlu5-HTL14242
15.15Single5D6LS-Carazolol5D6L-β2-S-Carazolol
15.15Single5IUAQ274563485IUA-A2A-Q27456348-Na
15.15Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
15.15Single5WIUNemonapride5WIU-D4-Nemonapride
15.15Single5WIVNemonapride5WIV-D4-Nemonapride-Na
15.15Single5WQCEMPA5WQC-OX2-EMPA
15.15Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
15.15Single5XPRBosentan5XPR-ETB-Bosentan
15.15Single6E67BI1671076E67-β2-BI167107-Gs (fused)
15.15Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
15.15Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
15.15Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
15.15Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
15.15Single6LUQHaloperidol6LUQ-D2-Haloperidol
15.15Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
15.15Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
15.15Single6S0QZM-2413856S0Q-A2A-ZM-241385
15.15Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
15.15Single6TP6Filorexant6TP6-OX1-Filorexant
15.15Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
15.15Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
15.15Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
15.15Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
15.15Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
15.15Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
15.15Single7SINNPS-21437SIN-CaS-NPS-2143
15.15Single7SINNPS-21437SIN-CaS-NPS-2143
15.15Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
15.15Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
15.15Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
15.15Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
15.15Single7W41PD1762527W41-BB2-PD176252
15.15Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
15.15Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
15.15Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.15Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.15Single8GNEKW-63568GNE-A2A-KW-6356-Na
15.15Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
15.15Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
15.15Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
15.15Single8ZMFA1L108ZMF-5-HT2C-A1L10
15.15Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
15.15Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
15.15Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
15.15Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
15.15Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
15.15Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
15.15Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
15.15Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
15.15Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
15.15Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
15.15Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
15.15Consensusamine_offonOrthosteric Ligandamine_off amine_on
15.15Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
15.15Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
15.15Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
15.15Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
15.15Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
15.15Consensusbombesin_offOrthosteric Ligandbb2_off
15.15Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
15.15Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
15.15Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
15.15Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
15.15Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
15.15Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
15.15Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
15.15Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
15.15Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
15.15Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
15.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
15.00Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
15.00Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
14.81Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
14.81Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
14.71Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
14.71Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
14.71Single5D5AS-Carazolol5D5A-β2-S-Carazolol
14.71Single5D5BS-Carazolol5D5B-β2-S-Carazolol
14.71Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
14.71Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
14.71Single6J20Aprepitant6J20-NK1-Aprepitant
14.71Single6J21Aprepitant6J21-NK1-Aprepitant
14.71Single6OS1TRV0266OS1-AT1-TRV026
14.71Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
14.71Single7F1TMIP-1a7F1T-CCR5-MIP-1a
14.71Single7PX4PSB-21137PX4-A2A-PSB-2113
14.71Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
14.71Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
14.71Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
14.71Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
14.71Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
14.71Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
14.71Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
14.71Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
14.71Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
14.71Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
14.71Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
14.71Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
14.71Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
14.71Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
14.71Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
14.71Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
14.71Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
14.71Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
14.71Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
14.71Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
14.71Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
14.71Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
14.71Consensusa2_onOrthosteric Liganda2b_on
14.71Consensusa2_on_gpOrthosteric Liganda2b_on_gp
14.71Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
14.71Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
14.71Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
14.71Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
14.71Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
14.71Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
14.71Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
14.71Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
14.71Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
14.71Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
14.71Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
14.71Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
14.71Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
14.71Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
14.71Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
14.63Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
14.63Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
14.29Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
14.29Single3D4STimolol3D4S-β2-Timolol
14.29Single3OE8IT1t3OE8-CXCR4-IT1t
14.29Single4AMIBucindolol4AMI-β1-Bucindolol
14.29Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
14.29Single5CXVTiotropium5CXV-M1-Tiotropium
14.29Single5X33BIIL2605X33-BLT1-BIIL260
14.29Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
14.29Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
14.29Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
14.29Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
14.29Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
14.29Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
14.29Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
14.29Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
14.29Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
14.29Single8A2OTheophylline8A2O-A2A-Theophylline-Na
14.29Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
14.29Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
14.29Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
14.29Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8XWMCXCL68XWM-CXCR2-CXCL6
14.29Single8XWSCXCL58XWS-CXCR2-CXCL5
14.29Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
14.29Single9CHUNoradrenaline9CHU-β2-Noradrenaline
14.29Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
14.29Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
14.29Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
14.29Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
14.29Consensusalpha1_offOrthosteric Ligandalpha1a_off
14.29Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
14.29Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
14.29Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
14.29Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
14.29Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
13.89Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
13.89Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
13.89Single6H7LDobutamine6H7L-β1-Dobutamine
13.89Single6IBLArformoterol6IBL-β1-Arformoterol
13.89Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
13.89Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
13.89Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
13.89Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
13.89Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
13.89Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
13.89Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.89Single8XVJMacitentan8XVJ-ETA-Macitentan
13.89Single8XWFCXCL38XWF-CXCR2-CXCL3
13.89Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
13.89Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
13.89Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
13.79Single4XNWMRS25004XNW-P2Y1-MRS2500
13.79Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
13.79Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
13.79Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
13.79Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
13.79Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.79Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
13.79Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
13.79Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
13.79Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
13.79Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
13.79Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
13.79Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
13.79Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
13.79Consensus5ht2_onOrthosteric Ligand5ht2b_on
13.79Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.79Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
13.79Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
13.79Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
13.64Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
13.51Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
13.51Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
13.51Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
13.51Single7SK9CCX6627SK9-ACKR3-CCX662
13.51Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
13.51Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
13.51Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
13.51Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
13.51Consensuskisspeptin_onOrthosteric Ligandkiss1_on
13.51Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
13.33Single5L7IVismodegib5L7I-SMO-Vismodegib
13.33Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
13.33Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
13.33Single7SRQLSD7SRQ-5-HT2B-LSD
13.33Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
13.33Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
13.33Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
13.33Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
13.33Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
13.33Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
13.33Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
13.33Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
13.33Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
13.33Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
13.33Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
13.33Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
13.33Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
13.33Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
13.33Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
13.33Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
13.33Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
13.33Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
13.33Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
13.33Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
13.33Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
13.33Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
13.33Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
13.33Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
13.33Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
13.33Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
13.33Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
13.33Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
13.16Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
13.16Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
13.16Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
13.16Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
13.16Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.16Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
13.16Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
13.16Single8KIGSHU91198KIG-MC3-SHU9119-Ca
13.16Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
13.16Single8XWNCXCL88XWN-CXCR2-CXCL8
13.16Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
13.16Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
13.16Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
13.16Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
13.16Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
12.90Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
12.90Single3PWHZM-2413853PWH-A2A-ZM-241385
12.90Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
12.90Single4S0VSuvorexant4S0V-OX2-Suvorexant
12.90Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
12.90Single5WS3EMPA5WS3-OX2-EMPA
12.90Single5ZKQABT-4915ZKQ-PAF-ABT-491
12.90Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
12.90Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
12.90Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
12.90Single6ME2Ramelteon6ME2-MT1-Ramelteon
12.90Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
12.90Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
12.90Single6TODEMPA6TOD-OX1-EMPA-Na
12.90Single6TPJSuvorexant6TPJ-OX2-Suvorexant
12.90Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
12.90Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
12.90Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
12.90Single7F8ULintitript7F8U-CCKA-Lintitript
12.90Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
12.90Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
12.90Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.90Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
12.90Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
12.90Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
12.90Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
12.90Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
12.90Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
12.90Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
12.90Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
12.90Single7XRRLemborexant7XRR-OX2-Lemborexant
12.90Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
12.90Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
12.90Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
12.90Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
12.90Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
12.90Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
12.90Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
12.90Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
12.90Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
12.90Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.90Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.90Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.90Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
12.90Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
12.90Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
12.90Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
12.90Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
12.90Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
12.90Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
12.90Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
12.90Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.90Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
12.90Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
12.90Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
12.90Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
12.90Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
12.90Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
12.90Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
12.90Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
12.90Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
12.90Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
12.90Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
12.90Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
12.90Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
12.90Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
12.90Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
12.90Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
12.90Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
12.82Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
12.82Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
12.82Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
12.50Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
12.50Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
12.50Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
12.50Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
12.50Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
12.50Single5UVIZM-2413855UVI-A2A-ZM-241385
12.50Single6A94Zotepine6A94-5-HT2A-Zotepine
12.50Single6AQFZM-2413856AQF-A2A-ZM-241385
12.50Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
12.50Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
12.50Single6IQLL7458706IQL-D4-L745870
12.50Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
12.50Single6KUXRS-799486KUX-α2a-RS-79948
12.50Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
12.50Single6MH8ZM-2413856MH8-A2A-ZM-241385
12.50Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
12.50Single6TP3Nemorexant6TP3-OX1-Nemorexant
12.50Single6TPNHTL66416TPN-OX2-HTL6641
12.50Single6VI4JDTic6VI4-κ-JDTic
12.50Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
12.50Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
12.50Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
12.50Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
12.50Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
12.50Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
12.50Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
12.50Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
12.50Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
12.50Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
12.50Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
12.50Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
12.50Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
12.50Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
12.50Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.50Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
12.50Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
12.50Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.50Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
12.50Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.50Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.50Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
12.50Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
12.50Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
12.50Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
12.50Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
12.50Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
12.50Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
12.50Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
12.50Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
12.50Consensusalpha1_onOrthosteric Ligandalpha1a_on
12.50Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
12.50Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
12.50Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
12.50Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
12.50Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
12.50Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
12.50Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
12.50Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
12.50Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
12.50Consensusopsins_offOrthosteric Ligandrhodopsin_off
12.50Consensussensory_offOrthosteric Ligandopsins_off
12.20Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
12.20Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
12.12Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
12.12Single2Y01Dobutamine2Y01-β1-Dobutamine
12.12Single2Y02Carmoterol2Y02-β1-Carmoterol
12.12Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
12.12Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
12.12Single4EJ4Naltrindole4EJ4-δ-Naltrindole
12.12Single4MQSIperoxo4MQS-M2-Iperoxo
12.12Single4QIMANTA XV4QIM-SMO-ANTA XV
12.12Single4U14Tiotropium4U14-M3-Tiotropium
12.12Single5DSGTiotropium5DSG-M4-Tiotropium
12.12Single5UIGCmpd-15UIG-A2A-Cmpd-1
12.12Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
12.12Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
12.12Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
12.12Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
12.12Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
12.12Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
12.12Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
12.12Single7BU7BI1671077BU7-β1-BI167107
12.12Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
12.12Single7F83PF-051904577F83-Ghrelin-PF-05190457
12.12Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
12.12Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
12.12Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
12.12Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
12.12Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
12.12Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
12.12Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
12.12Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
12.12Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
12.12Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
12.12Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
12.12Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
12.12Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
12.12Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
12.12Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
12.12Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
12.12Single8X64Desloratadine8X64-H1-Desloratadine
12.12Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
12.12Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
12.12Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
12.12Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
12.12Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
12.12Single9IYAONO-97105319IYA-GPR55-ONO-9710531
12.12Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
12.12Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
12.12Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
12.12Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
12.12Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
12.12Consensusalpha2_onOrthosteric Ligandalpha2b_on
12.12Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
12.12Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
12.12Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
12.12Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
12.12Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
12.12Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
12.12Consensusblt_onOrthosteric Ligandblt1_on
12.12Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
12.12Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
12.12Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
12.12Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
12.12Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
12.12Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
12.12Consensusleukotriene_onOrthosteric Ligandblt_on
12.12Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
12.12Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
12.12Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
12.12Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
12.12Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
11.90Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Single2Y00Dobutamine2Y00-β1-Dobutamine
11.76Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
11.76Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
11.76Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
11.76Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
11.76Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
11.76Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
11.76Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
11.76Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
11.76Single7WC6LSD7WC6-5-HT2A-LSD
11.76Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
11.76Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
11.76Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
11.76Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
11.76Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
11.76Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
11.76Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
11.76Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
11.76Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
11.76Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
11.76Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
11.76Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
11.76Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
11.76Consensusep_offOrthosteric Ligandep4_off
11.76Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.43Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
11.43Single4U15Tiotropium4U15-M3-Tiotropium
11.43Single5TZRMK86665TZR-FFA1-MK8666
11.43Single6E59L-7607356E59-NK1-L-760735
11.43Single6OL9Tiotropium6OL9-M5-Tiotropium
11.43Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
11.43Single7P2L4YI7P2L-mGlu5-4YI
11.43Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
11.43Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
11.43Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
11.43Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
11.43Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
11.43Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
11.43Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
11.43Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
11.43Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
11.43Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
11.43Single8XVLZibotentan8XVL-ETA-Zibotentan
11.43Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
11.43Single9BJKNAM9BJK-μ-Naloxone-NAM
11.43Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
11.43Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
11.43Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
11.43Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
11.11Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
11.11Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
11.11Single4PY02MeSATP4PY0-P2Y12-2MeSATP
11.11Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
11.11Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
11.11Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
11.11Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
11.11Single8XWACXCL18XWA-CXCR2-CXCL1
11.11Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
11.11Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
11.11Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
11.11Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
10.81Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
10.81Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
10.81Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
10.81Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.81Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
10.71Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
10.71Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
10.71Single8HS2Fab0468HS2-GPR20-Fab046
10.71Single8PWNTheophylline8PWN-A2A-Theophylline
10.71Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
10.53Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
10.53Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
10.53Single8XQJJN2418XQJ-Apelin-JN241
10.53Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
10.53Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
10.34Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
10.34Single3RFMCaffeine3RFM-A2A-Caffeine
10.34Single6TQ9SB-4081246TQ9-OX1-SB-408124
10.34Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
10.34Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
10.34Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
10.34Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
10.34Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
10.34Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
10.34Consensusp2y_offOrthosteric Ligandp2y1_off
10.26Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
10.00Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
10.00Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
10.00Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
10.00Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
10.00Single6ME5Agomelatine6ME5-MT1-Agomelatine
10.00Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
10.00Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
10.00Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
10.00Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
10.00Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
10.00Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
10.00Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
10.00Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
10.00Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
10.00Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
10.00Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
10.00Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
10.00Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
10.00Consensusgi_sensoryOrthosteric Ligandgi_opsins
10.00Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
10.00Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
10.00Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
9.68Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
9.68Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
9.68Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
9.68Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
9.68Single3PBLEticlopride3PBL-D3-Eticlopride
9.68Single4O9RCyclopamine4O9R-SMO-Cyclopamine
9.68Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
9.68Single6HLLCP999946HLL-NK1-CP99994
9.68Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
9.68Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
9.68Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
9.68Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
9.68Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
9.68Single7UL2SR486927UL2-NTS1-SR48692-Na
9.68Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
9.68Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
9.68Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
9.68Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
9.68Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
9.68Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
9.68Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.68Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.68Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
9.68Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
9.68Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
9.68Consensusgq_nucleotideOrthosteric Ligandgq_p2y
9.68Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
9.68Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
9.68Consensusneurotensin_offOrthosteric Ligandnts1_off
9.68Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
9.38Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
9.38Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
9.38Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
9.38Single4QINSAG1.54QIN-SMO-SAG1.5
9.38Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
9.38Single6DS0Ly2660976DS0-5-HT2B-Ly266097
9.38Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
9.38Single6ME9Ramelteon6ME9-MT2-Ramelteon
9.38Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
9.38Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
9.38Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
9.38Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
9.38Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
9.38Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
9.38Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
9.38Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
9.38Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
9.38Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
9.38Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.38Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
9.38Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.38Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
9.38Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
9.38Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
9.38Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
9.38Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
9.09Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
9.09Single3REYXAC3REY-A2A-XAC
9.09Single3RZECidoxepin3RZE-H1-Cidoxepin
9.09Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
9.09Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
9.09Single6TPKRetosiban6TPK-OT-Retosiban
9.09Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
9.09Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
9.09Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
9.09Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
9.09Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
9.09Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
9.09Single7VODCariprazine7VOD-5-HT2A-Cariprazine
9.09Single7VV6C48/807VV6-MRGPRX2-C48/80
9.09Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
9.09Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
9.09Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
9.09Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
9.09Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
9.09Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
9.09Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
9.09Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
9.09Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
9.09Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
9.09Single9BJKNaloxone9BJK-μ-Naloxone-NAM
9.09Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
9.09Consensusvasop-oxy_offOrthosteric Ligandot_off
8.82Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
8.82Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
8.82Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.82Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.82Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
8.82Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
8.82Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
8.82Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
8.57Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
8.57Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
8.57Single6Z4SSR486926Z4S-NTS1-SR48692
8.57Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.57Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
8.57Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
8.57Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
8.57Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
8.57Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
8.33Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
8.33Single7R0CAVP7R0C-V2-AVP-Arrestin2
8.33Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
8.33Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
8.33Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
8.33Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
8.33Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
8.33Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
8.33Consensustachykinin_offOrthosteric Ligandnk1_off
8.11Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
8.11Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
8.11Single8XQJJN2418XQJ-Apelin-JN241
8.11Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
8.11Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
7.89Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
7.69Single6KNMJN241-96KNM-Apelin-JN241-9
7.69Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
7.69Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
7.50Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
7.50Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
7.50Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
7.50Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
7.32Single7SHEPI; PE7SHE-GPR158-PI; PE
7.14Single5MZPCaffeine5MZP-A2A-Caffeine-Na
7.14Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
6.90Single7WC4Serotonin7WC4-5-HT2A-Serotonin
6.90Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
6.90Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
6.90Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
6.67Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
6.67Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
6.67Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
6.67Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
6.67Consensussensory_onOrthosteric Ligandopsins_on
6.45Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
6.45Single3UZAGTPL92363UZA-A2A-GTPL9236
6.45Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
6.45Single7V6A-7V6A-M4-PubChem 9864275-Gi1/β1/γ2
6.45Single7WC5Psilocin7WC5-5-HT2A-Psilocin
6.45Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.45Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
6.45Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
6.45Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
6.45Single8JPSCCL78JPS-ACKR1-CCL7
6.45Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
6.45Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
6.45Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
6.45Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
6.45Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
6.25Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
6.25Single6TP4ACT-4622066TP4-OX1-ACT-462206
6.25Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
6.25Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
6.25Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
6.06Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
6.06Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
6.06Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
6.06Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.06Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
6.06Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
5.88Single6FFIMMPEP6FFI-mGlu5-MMPEP
5.88Single6ZINSR486926ZIN-NTS1-SR48692
5.88Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
5.88Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
5.71Single6FFHFenobam6FFH-mGlu5-Fenobam
5.71Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
5.71Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
5.56Single4NTJAZD12834NTJ-P2Y12-AZD1283
5.56Single6HLPNetupitant6HLP-NK1-Netupitant
5.56Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
5.56Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
5.41Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
5.26Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
5.13Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
5.13Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
4.76Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.85Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
3.85Single6D35Cholesterol6D35-SMO-Cholesterol
3.85Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
3.85Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
3.85Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
3.85Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
3.85Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
3.85Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
3.85Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
3.85Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
3.85Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
3.85Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
3.85Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.85Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.85Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.85Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.85Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
3.85Single7DTTCa7DTT-CaS-Ca-Ca
3.85Single7DTTCa7DTT-CaS-Ca-Ca
3.85Single7DTUTryptophan7DTU-CaS-Tryptophan
3.85Single7DTUTryptophan7DTU-CaS-Tryptophan
3.85Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
3.85Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
3.85Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
3.85Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
3.85Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.85Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.85Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.85Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.85Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
3.85Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
3.85Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
3.85Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
3.85Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
3.85Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
3.85Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
3.85Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
3.85Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
3.85Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
3.85Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
3.85Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
3.85Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
3.85Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
3.85Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
3.85Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
3.85Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
3.85Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.85Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.85Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.85Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.85Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
3.85Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
3.85Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
3.85Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
3.85Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
3.85Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
3.85Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.85Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.85Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.85Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.85Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.85Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.85Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.85Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.85Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
3.85Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
3.85Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
3.85Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
3.85Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
3.85Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
3.85Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
3.85Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
3.85Single7XW7K1-707XW7-TSH-K1-70
3.85Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
3.85Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
3.85Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
3.85Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
3.85Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
3.85Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
3.85Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
3.85Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
3.85Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
3.85Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
3.85Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
3.85Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
3.85Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
3.85Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
3.85Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
3.85Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
3.85Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
3.85Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
3.85Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
3.85Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
3.85Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
3.85Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
3.85Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
3.85Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
3.85Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
3.85Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
3.85Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
3.85Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
3.85Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
3.85Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
3.85Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
3.85Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
3.85Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
3.85Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
3.85Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
3.85Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
3.85Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
3.85Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
3.85Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.85Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.85Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
3.85Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
3.85Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
3.85Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
3.85Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
3.85Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
3.85Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
3.85Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
3.85Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
3.85Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
3.85Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
3.85Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
3.85Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
3.85Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
3.85Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
3.85Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
3.85Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
3.85Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
3.85Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.85Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.85Single8WVXNorrin8WVX-LGR4-Norrin
3.85Single8WVYNorrin8WVY-LGR4-Norrin
3.85Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
3.85Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
3.85Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
3.85Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
3.85Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
3.85Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
3.85Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
3.85Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
3.85Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
3.85Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
3.85Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
3.85Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
3.85Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
3.85Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
3.85Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
3.85Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
3.85Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
3.85Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
3.85Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
3.85Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
3.85Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
3.85Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
3.85Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
3.85Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
3.85Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
3.85Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
3.85Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
3.85Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
3.85Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
3.85Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
3.85Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
3.85Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
3.85Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
3.85Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
3.85Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
3.70Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.70Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.70Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.70Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.70Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.70Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.70Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.70Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.70Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
3.70Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
3.70Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
3.70Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
3.57Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
3.57Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
3.57Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
3.57Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
3.45Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
3.45Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
3.45Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
3.45Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
3.45Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
3.45Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
3.45Single9IVMLSN33188399IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
3.33Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
3.33Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
3.33Single5L7DCholesterol5L7D-SMO-Cholesterol
3.33Single6VCBLSN31604406VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
3.33Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
3.33Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
3.23Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
3.12Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
3.12Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
3.12Single8ZPLCholesterol8ZPL-CXCR4-HF51116-Cholesterol
3.12Single8ZPMCholesterol8ZPM-CXCR4-AMD070-Cholesterol
3.03Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
3.03Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.03Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
3.03Single8HNNSCH5467388HNN-CXCR3-SCH546738
2.94Single4K5YCP-3763954K5Y-CRF1-CP-376395
2.94Single4XNVBPTU4XNV-P2Y1-BPTU
2.94Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
2.86Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
2.86Single8IYXYL-3658IYX-GPR34-YL-365
2.86Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
2.78Single4Z9GCP-3763954Z9G-CRF1-CP-376395
2.78Single8GTIBMK-C2058GTI-CRF1-BMK-C205
2.70Single8GTGBMK-I1528GTG-CRF1-BMK-I152
2.56Single7SHEPI; PE7SHE-GPR158-PI; PE
2.56Single8GTMBMK-C2038GTM-CRF1-BMK-C203
2.50Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.38Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
2.38Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
2.27Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
2.27Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
2.22Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
2.08Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3

PDB Summary
PDB 8FLU
Class B1
SubFamily Peptide
Type Parathyroid Hormone
SubType PTH1
Species Homo Sapiens
Ligand Long-Acting PTH
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 2.76
Date 2023-04-26
D.O.I. 10.1016/j.str.2023.04.002
Net Summary
Imin 3.71
Number of Linked Nodes 960
Number of Links 1179
Number of Hubs 204
Number of Links mediated by Hubs 733
Number of Communities 29
Number of Nodes involved in Communities 310
Number of Links involved in Communities 461
Path Summary
Number Of Nodes in MetaPath 174
Number Of Links MetaPath 173
Number of Shortest Paths 2005648
Length Of Smallest Path 3
Average Path Length 32.3055
Length of Longest Path 82
Minimum Path Strength 1.21
Average Path Strength 8.35755
Maximum Path Strength 30.99
Minimum Path Correlation 0.7
Average Path Correlation 0.991875
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.77778
Average % Of Corr. Nodes 55.9117
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 49.5431
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • molecular function activator activity   • phosphorus-oxygen lyase activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • adenylate cyclase activator activity   • adenylate cyclase activity   • cation binding   • metal ion binding   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development
Gene OntologyBiological Process• developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • cellular response to stimulus   • cellular response to nitrogen compound   • response to stimulus   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • cellular process   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • biological regulation   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • regulation of biological process   • regulation of cellular process   • signaling   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • positive regulation of cellular process   • protein localization   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • localization   • cellular macromolecule localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • intracellular anatomical structure   • cytoplasm   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • trans-Golgi network   • organelle membrane   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • identical protein binding   • protein homodimerization activity   • protein dimerization activity   • amide binding   • peptide hormone binding   • hormone binding   • peptide receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • G protein-coupled peptide receptor activity   • signaling receptor activity   • transmembrane signaling receptor activity   • parathyroid hormone receptor activity   • ossification   • bone mineralization   • biomineral tissue development   • tissue development   • skeletal system development   • inorganic ion homeostasis   • intracellular calcium ion homeostasis   • homeostatic process   • calcium ion homeostasis   • cellular homeostasis   • chemical homeostasis   • intracellular monoatomic cation homeostasis   • monoatomic ion homeostasis   • intracellular chemical homeostasis   • monoatomic cation homeostasis   • intracellular monoatomic ion homeostasis   • osteoblast development   • cellular developmental process   • cell differentiation   • cell development   • osteoblast differentiation   • embryo development ending in birth or egg hatching   • chordate embryonic development   • embryo development   • in utero embryonic development   • anatomical structure maturation   • cell maturation   • developmental maturation   • positive regulation of cell population proliferation   • regulation of cell population proliferation   • positive regulation of biological process   • positive regulation of cellular process   • cell surface receptor signaling pathway   • negative regulation of cell population proliferation   • negative regulation of cellular process   • negative regulation of biological process   • connective tissue development   • chondrocyte differentiation   • cartilage development   • regulation of inositol phosphate biosynthetic process   • alcohol metabolic process   • positive regulation of phosphate metabolic process   • inositol phosphate metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • regulation of phosphate metabolic process   • phosphate-containing compound metabolic process   • polyol biosynthetic process   • small molecule metabolic process   • phosphorus metabolic process   • regulation of carbohydrate metabolic process   • regulation of biosynthetic process   • carbohydrate metabolic process   • polyol metabolic process   • positive regulation of phosphorus metabolic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • carbohydrate biosynthetic process   • primary metabolic process   • positive regulation of inositol phosphate biosynthetic process   • biosynthetic process   • organophosphate metabolic process   • organophosphate biosynthetic process   • inositol phosphate biosynthetic process   • alcohol biosynthetic process   • regulation of phosphorus metabolic process   • metabolic process   • positive regulation of carbohydrate metabolic process   • regulation of carbohydrate biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • multicellular organismal-level homeostasis   • tissue remodeling   • bone remodeling   • anatomical structure homeostasis   • tissue homeostasis   • bone resorption   • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • apical part of cell   • plasma membrane region   • apical plasma membrane   • basal part of cell   • basal plasma membrane   • basolateral plasma membrane   • receptor complex
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8FLU_Chain_A
RNEEKAQRE ANKKIEKQL QKDKQVYRA THRLLLLGA GESGKNTIV 
KQMSGIFET KFQVDKVNF HMFDVGAQR DERRKWIQC FNDVTAIIF 
VVASSQTNR LQAALKLFD SIWNNKWLR DTSVILFLN KQDLLAEKV 
LAGKSKIED YFPEFARYT TPEDATPEP GEDPRVTRA KYFIRDEFL 
RISTASGDG RHYCYPHFT CAVDTENIR RVFNDCRDI IQRMHLRQY 
ELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8FLU_Chain_B
LDQLRQEAE QLKNQIRDA RKACADATL SQITNNIDP VGRIQMRTR 
RTLRGHLAK IYAMHWGTD SRLLVSASQ DGKLIIWDS YTTNKVHAI 
PLRSSWVMT CAYAPSGNY VACGGLDNI CSIYNLKTR EGNVRVSRE 
LAGHTGYLS CCRFLDDNQ IVTSSGDTT CALWDIETG QQTTTFTGH 
TGDVMSLSL APDTRLFVS GACDASAKL WDVREGMCR QTFTGHESD 
INAICFFPN GNAFATGSD DATCRLFDL RADQELMTY SHDNIICGI 
TSVSFSKSG RLLLAGYDD FNCNVWDAL KADRAGVLA GHDNRVSCL 
GVTDDGMAV ATGSWDSFL KIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8FLU_Chain_G
SIAQARKLV EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT 
PVPASENPF R


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ03431
Sequence
>8FLU_Chain_R
VMTKEEQIF LLHRAQAQC EKRLKEGRP CLPEWDHIL CWPLGAPGE 
VVAVPCPDY IYDFNHKGH AYRRCDRNG SWELVPGHN RTWANYSEC 
VKFLTNETR EREVFDRLG MIYTVGYSV SLASLTVAV LILAYFRRL 
HCTRNYIHM HLFLSFMLR AVSIFVKDA VLYSAGYAG CRVAVTFFL 
YFLATNYYW ILVEGLYLH SLIFMAFFS EKKYLWGFT VFGWGLPAV 
FVAVWVSVR ATLANTGCW DLSSGNKKW IIQVPILAS IVLNFILFI 
NIVRVLATK LRETTRQQY RKLLKSTLV LMPLFGVHY IVFMATPYT 
EVSGTLWQV QMHYEMLFN SFQGFFVAI IYCFCNGEV QAEIKKSWS 
RWT


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9JR3B1PeptideParathyroid HormonePTH1Homo sapiensPTH-chim(NtGi1L-Gs-CtGq)/β1/γ22.82024-10-16To be published
9JR3 (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTH-2.82024-10-16To be published
9JR2B1PeptideParathyroid HormonePTH1Homo sapiensPTH-chim(NtGi1L-Gs-CtGq)/β1/γ22.82024-10-16To be published
9JR2 (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTH-2.82024-10-16To be published
8JR9B1PeptideParathyroid HormonePTH1Homo sapiens-PCO371chim(NtGi1-Gs)/β1/γ22.572023-08-0210.1038/s41586-023-06467-w
8JR9 (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiens-PCO3712.572023-08-0210.1038/s41586-023-06467-w
7Y36B1PeptideParathyroid HormonePTH1Homo sapiensTeriparatide-Gs/β1/γ22.82023-07-05To be published
7Y36 (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensTeriparatide-2.82023-07-05To be published
7Y35B1PeptideParathyroid HormonePTH1Homo sapiensAbaloparatide-Gs/β1/γ22.92023-07-05To be published
7Y35 (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensAbaloparatide-2.92023-07-05To be published
8GW8B1PeptideParathyroid HormonePTH1Homo sapiens-KHFGs/β1/γ22.92023-06-1410.1038/s41586-023-06169-3
8GW8 (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiens-KHF2.92023-06-1410.1038/s41586-023-06169-3
8FLUB1PeptideParathyroid HormonePTH1Homo sapiensLong-Acting PTH-Gs/β1/γ22.762023-04-2610.1016/j.str.2023.04.002
8FLU (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensLong-Acting PTH-2.762023-04-2610.1016/j.str.2023.04.002
8FLTB1PeptideParathyroid HormonePTH1Homo sapiensM-PTH(1-14)-Gs/β1/γ23.032023-04-2610.1016/j.str.2023.04.002
8FLT (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensM-PTH(1-14)-3.032023-04-2610.1016/j.str.2023.04.002
8FLSB1PeptideParathyroid HormonePTH1Homo sapiensAbaloparatide-Gs/β1/γ23.092023-04-2610.1016/j.str.2023.04.002
8FLS (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensAbaloparatide-3.092023-04-2610.1016/j.str.2023.04.002
8FLRB1PeptideParathyroid HormonePTH1Homo sapiensPTHrP(1-36)-Gs/β1/γ22.942023-04-2610.1016/j.str.2023.04.002
8FLR (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTHrP(1-36)-2.942023-04-2610.1016/j.str.2023.04.002
8FLQB1PeptideParathyroid HormonePTH1Homo sapiensPTH-Gs/β1/γ22.552023-04-2610.1016/j.str.2023.04.002
8FLQ (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTH-2.552023-04-2610.1016/j.str.2023.04.002
8HAOB1PeptideParathyroid HormonePTH1Homo sapiensPTH-chim(NtGi1-Gs)/β1/γ23.762022-12-2110.1038/s41401-022-01032-z
8HAO (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTH-3.762022-12-2110.1038/s41401-022-01032-z
8HAFB1PeptideParathyroid HormonePTH1Homo sapiensPTHrP(1-36)-chim(NtGi1-Gs)/β1/γ23.252022-12-2110.1038/s41401-022-01032-z
8HAF (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTHrP(1-36)-3.252022-12-2110.1038/s41401-022-01032-z
8HA0B1PeptideParathyroid HormonePTH1Homo sapiensPTH-chim(NtGi1-Gs)/β1/γ22.622022-12-2110.1038/s41401-022-01032-z
8HA0 (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTH-2.622022-12-2110.1038/s41401-022-01032-z
7VVOB1PeptideParathyroid HormonePTH1Homo sapiensPTH-Gs/β1/γ24.12022-08-0310.1016/j.molcel.2022.07.003
7VVO (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTH-4.12022-08-0310.1016/j.molcel.2022.07.003
7VVNB1PeptideParathyroid HormonePTH1Homo sapiensPTH-Gs/β1/γ23.82022-08-0310.1016/j.molcel.2022.07.003
7VVN (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTH-3.82022-08-0310.1016/j.molcel.2022.07.003
7VVMB1PeptideParathyroid HormonePTH1Homo sapiensPTH-Gs/β1/γ23.22022-08-0310.1016/j.molcel.2022.07.003
7VVM (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTH-3.22022-08-0310.1016/j.molcel.2022.07.003
7VVLB1PeptideParathyroid HormonePTH1Homo sapiensPTH-Gs/β1/γ22.82022-08-0310.1016/j.molcel.2022.07.003
7VVL (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTH-2.82022-08-0310.1016/j.molcel.2022.07.003
7VVKB1PeptideParathyroid HormonePTH1Homo sapiensPTH-Gs/β1/γ23.32022-08-0310.1016/j.molcel.2022.07.003
7VVK (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTH-3.32022-08-0310.1016/j.molcel.2022.07.003
7VVJB1PeptideParathyroid HormonePTH1Homo sapiensPTHrP(1-36)-Gs/β1/γ23.22022-08-0310.1016/j.molcel.2022.07.003
7VVJ (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTHrP(1-36)-3.22022-08-0310.1016/j.molcel.2022.07.003
6NBIB1PeptideParathyroid HormonePTH1Homo sapiensLong-Acting PTH Analog-Gs/β1/γ242019-04-1710.1126/science.aav7942
6NBI (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensLong-Acting PTH Analog-42019-04-1710.1126/science.aav7942
6NBHB1PeptideParathyroid HormonePTH1Homo sapiensLong-Acting PTH Analog-Gs/β1/γ23.52019-04-1710.1126/science.aav7942
6NBH (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensLong-Acting PTH Analog-3.52019-04-1710.1126/science.aav7942
6NBFB1PeptideParathyroid HormonePTH1Homo sapiensLong-Acting PTH Analog-Gs/β1/γ232019-04-1710.1126/science.aav7942
6NBF (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensLong-Acting PTH Analog-32019-04-1710.1126/science.aav7942
6FJ3B1PeptideParathyroid HormonePTH1Homo sapiensPTH--2.52018-11-2110.1038/s41594-018-0151-4




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