psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?0	L:L:A1	7.08	Yes	No	1	0	0
2	L:L:?0	R:R:W361	10.23	Yes	Yes	1	0	8
3	L:L:?0	R:R:Q364	3.99	Yes	Yes	1	0	7
4	L:L:?0	R:R:L368	6.22	Yes	No	0	0	4
5	L:L:A1	L:L:Q6	4.55	No	Yes	1	0	0
6	L:L:A1	R:R:Y429	4	No	Yes	1	0	6
7	L:L:I5	L:L:V2	12.29	No	No	0	0	0
8	L:L:A3	R:R:E444	6.03	No	No	0	0	7
9	L:L:E4	R:R:Y195	5.61	No	Yes	4	0	7
10	L:L:E4	R:R:I237	4.1	No	Yes	4	0	7
11	L:L:E4	R:R:M445	8.12	No	No	0	0	6
12	L:L:H9	L:L:I5	6.63	Yes	No	0	0	0
13	L:L:I5	R:R:Q364	4.12	No	Yes	0	0	7
14	L:L:Q6	R:R:Y429	15.78	Yes	Yes	1	0	6
15	L:L:Q6	R:R:W437	5.48	Yes	Yes	1	0	5
16	L:L:Q6	R:R:M441	6.8	Yes	Yes	1	0	6
17	L:L:L7	R:R:M441	5.65	No	Yes	0	0	6
18	L:L:L7	R:R:M445	5.65	No	No	0	0	6
19	L:L:H9	L:L:M8	5.25	Yes	No	0	0	0
20	L:L:M8	R:R:F288	6.22	No	Yes	0	0	7
21	L:L:M8	R:R:D353	11.09	No	No	0	0	5
22	L:L:H9	R:R:S355	12.55	Yes	No	1	0	7
23	L:L:H9	R:R:K360	7.86	Yes	Yes	1	0	7
24	L:L:R11	R:R:F184	5.34	No	Yes	0	0	6
25	L:L:R11	R:R:Y245	16.46	No	No	0	0	4
26	L:L:A12	R:R:D353	6.18	No	No	0	0	5
27	L:L:A18	L:L:W14	9.08	No	Yes	0	0	0
28	L:L:R21	L:L:W14	4	No	Yes	0	0	0
29	L:L:W14	R:R:R181	33.99	Yes	No	0	0	3
30	L:L:Q16	L:L:R19	5.84	No	No	0	0	0
31	L:L:Q16	R:R:L354	6.65	No	No	0	0	5
32	L:L:D17	L:L:R20	11.91	No	No	0	0	0
33	L:L:D17	L:L:R21	9.53	No	No	0	0	0
34	L:L:R19	R:R:T33	6.47	No	No	0	0	7
35	L:L:R20	R:R:E35	9.3	No	No	0	0	5
36	L:L:F23	L:L:K26	6.2	Yes	No	0	0	0
37	L:L:F23	R:R:E35	5.83	Yes	No	0	0	5
38	L:L:F23	R:R:E36	5.83	Yes	No	0	0	6
39	L:L:I28	L:L:I31	4.42	No	No	0	0	0
40	R:R:I38	R:R:K34	5.82	No	No	0	7	4
41	R:R:I38	R:R:Q37	8.23	No	No	0	7	7
42	R:R:P132	R:R:Y134	8.34	No	No	0	9	5
43	R:R:D133	R:R:H140	12.61	No	No	0	2	3
44	R:R:I135	R:R:Y134	6.04	No	No	0	7	5
45	R:R:D137	R:R:I135	4.2	No	No	0	5	7
46	R:R:D137	R:R:F138	11.94	No	No	0	5	4
47	R:R:H140	R:R:N139	3.83	No	No	0	3	4
48	R:R:K141	R:R:N139	6.99	No	No	0	3	4
49	R:R:R179	R:R:T178	3.88	No	No	0	3	3
50	R:R:E180	R:R:R181	9.3	No	No	0	3	3
51	R:R:E180	R:R:V432	9.98	No	Yes	0	3	5
52	R:R:E180	R:R:S433	5.75	No	No	0	3	3
53	R:R:F184	R:R:R181	5.34	Yes	No	0	6	3
54	R:R:R186	R:R:V183	5.23	Yes	No	5	5	4
55	R:R:Q438	R:R:V183	5.73	No	No	5	4	4
56	R:R:H442	R:R:V183	4.15	Yes	No	5	5	4
57	R:R:F184	R:R:V432	3.93	Yes	Yes	1	6	5
58	R:R:F184	R:R:W437	5.01	Yes	Yes	1	6	5
59	R:R:H442	R:R:R186	9.03	Yes	Yes	5	5	5
60	R:R:L187	R:R:M441	4.24	No	Yes	0	5	6
61	R:R:H442	R:R:L187	12.86	Yes	No	0	5	5
62	R:R:G188	R:R:Y191	5.79	No	Yes	0	5	7
63	R:R:Y191	R:R:Y195	7.94	Yes	Yes	4	7	7
64	R:R:I237	R:R:Y191	4.84	Yes	Yes	4	7	7
65	R:R:D241	R:R:Y191	11.49	No	Yes	4	8	7
66	R:R:M445	R:R:Y191	7.18	No	Yes	0	6	7
67	R:R:F238	R:R:T192	5.19	No	No	0	7	7
68	R:R:R233	R:R:Y195	7.2	No	Yes	0	8	7
69	R:R:I237	R:R:Y195	7.25	Yes	Yes	4	7	7
70	R:R:S449	R:R:Y195	11.45	No	Yes	0	9	7
71	R:R:F453	R:R:V197	5.24	No	No	0	6	5
72	R:R:L199	R:R:M231	5.65	No	No	0	7	8
73	R:R:F453	R:R:S201	5.28	No	No	0	6	8
74	R:R:F227	R:R:L202	4.87	No	No	0	9	9
75	R:R:M231	R:R:T203	4.52	No	No	0	8	3
76	R:R:M224	R:R:V206	4.56	No	No	0	5	5
77	R:R:F227	R:R:V206	3.93	No	No	0	9	5
78	R:R:I208	R:R:I470	4.42	No	No	0	8	5
79	R:R:L209	R:R:M224	5.65	No	No	0	7	5
80	R:R:C460	R:R:L209	4.76	No	No	0	9	7
81	R:R:F212	R:R:L215	4.87	No	No	0	7	9
82	R:R:E469	R:R:F212	12.83	No	No	0	9	7
83	R:R:F212	R:R:S473	3.96	No	No	0	7	4
84	R:R:H216	R:R:R213	5.64	No	No	0	8	8
85	R:R:H216	R:R:Y221	7.62	No	No	0	8	7
86	R:R:C217	R:R:R219	4.18	No	Yes	6	8	9
87	R:R:C217	R:R:N220	4.72	No	No	6	8	9
88	R:R:T218	R:R:Y305	7.49	No	No	0	7	8
89	R:R:N220	R:R:R219	6.03	No	Yes	6	9	9
90	R:R:H223	R:R:R219	7.9	No	Yes	0	9	9
91	R:R:E302	R:R:I222	8.2	Yes	No	0	9	9
92	R:R:E302	R:R:H223	9.85	Yes	No	0	9	9
93	R:R:H223	R:R:Y459	4.36	No	Yes	0	9	8
94	R:R:H225	R:R:W298	14.81	No	Yes	0	8	9
95	R:R:L226	R:R:S229	4.5	No	No	0	9	9
96	R:R:F230	R:R:L226	6.09	Yes	No	0	8	9
97	R:R:E302	R:R:L226	11.93	Yes	No	0	9	9
98	R:R:L228	R:R:L232	4.15	No	No	0	4	8
99	R:R:N295	R:R:S229	5.96	Yes	No	0	8	9
100	R:R:S229	R:R:W298	7.41	No	Yes	0	9	9
101	R:R:F230	R:R:N295	19.33	Yes	Yes	2	8	8
102	R:R:F230	R:R:I299	6.28	Yes	No	2	8	9
103	R:R:F230	R:R:Q451	7.03	Yes	Yes	2	8	9
104	R:R:F291	R:R:L232	17.05	No	No	0	5	8
105	R:R:L292	R:R:R233	7.29	No	No	0	6	8
106	R:R:N295	R:R:R233	12.05	Yes	No	0	8	8
107	R:R:F288	R:R:S236	3.96	Yes	No	0	7	7
108	R:R:F291	R:R:S236	9.25	No	No	0	5	7
109	R:R:D241	R:R:I237	4.2	No	Yes	4	8	7
110	R:R:F288	R:R:I237	3.77	Yes	Yes	0	7	7
111	R:R:D241	R:R:K240	5.53	No	No	0	8	7
112	R:R:K240	R:R:L244	4.23	No	Yes	0	7	5
113	R:R:F288	R:R:K240	17.37	Yes	No	0	7	7
114	R:R:L244	R:R:Y245	9.38	Yes	No	0	5	4
115	R:R:D353	R:R:L244	4.07	No	Yes	0	5	5
116	R:R:G277	R:R:R282	4.5	No	No	0	4	8
117	R:R:C281	R:R:C351	7.28	No	No	0	9	9
118	R:R:N348	R:R:R282	10.85	No	No	0	7	8
119	R:R:R282	R:R:W352	24.99	No	No	0	8	8
120	R:R:F287	R:R:V283	3.93	No	No	0	3	4
121	R:R:T286	R:R:V340	4.76	No	No	0	7	5
122	R:R:F288	R:R:L289	4.87	Yes	Yes	0	7	7
123	R:R:L289	R:R:W339	4.56	Yes	Yes	3	7	8
124	R:R:I363	R:R:L289	5.71	No	Yes	3	7	7
125	R:R:F291	R:R:Y290	5.16	No	Yes	0	5	9
126	R:R:T294	R:R:Y290	8.74	No	Yes	7	8	9
127	R:R:W329	R:R:Y290	7.72	No	Yes	7	9	9
128	R:R:A333	R:R:Y290	5.34	No	Yes	0	5	9
129	R:R:V336	R:R:Y290	6.31	No	Yes	0	7	9
130	R:R:L292	R:R:Y296	7.03	No	Yes	0	6	7
131	R:R:A293	R:R:F335	4.16	No	Yes	0	6	5
132	R:R:T294	R:R:W329	8.49	No	No	7	8	9
133	R:R:I299	R:R:N295	5.66	No	Yes	2	9	8
134	R:R:I367	R:R:Y296	6.04	No	Yes	0	7	7
135	R:R:I371	R:R:Y296	6.04	No	Yes	2	7	7
136	R:R:Y296	R:R:Y421	17.87	Yes	Yes	2	7	8
137	R:R:F327	R:R:Y297	7.22	No	No	0	5	6
138	R:R:L331	R:R:Y297	7.03	No	No	0	4	6
139	R:R:P332	R:R:Y297	13.91	No	No	0	9	6
140	R:R:V301	R:R:W298	4.9	No	Yes	0	8	9
141	R:R:T325	R:R:W298	6.06	No	Yes	0	5	9
142	R:R:W298	R:R:W329	16.87	Yes	No	0	9	9
143	R:R:I299	R:R:Q451	4.12	No	Yes	2	9	9
144	R:R:L300	R:R:L304	6.92	No	No	0	8	5
145	R:R:L300	R:R:S370	7.51	No	No	0	8	7
146	R:R:L300	R:R:L373	4.15	No	No	0	8	7
147	R:R:F324	R:R:V301	7.87	Yes	No	0	7	8
148	R:R:E302	R:R:L416	7.95	Yes	No	0	9	9
149	R:R:F417	R:R:G303	4.52	Yes	No	0	9	9
150	R:R:L304	R:R:L377	4.15	No	No	0	5	7
151	R:R:L309	R:R:Y305	14.07	No	No	0	8	8
152	R:R:I381	R:R:L306	7.14	No	No	0	9	9
153	R:R:F311	R:R:H307	14.71	No	No	8	6	8
154	R:R:H307	R:R:L377	5.14	No	No	0	8	7
155	R:R:H307	R:R:N380	11.48	No	No	8	8	8
156	R:R:M312	R:R:S308	6.13	No	No	0	5	7
157	R:R:F311	R:R:I310	8.79	No	No	0	6	8
158	R:R:F311	R:R:N380	7.25	No	No	8	6	8
159	R:R:F314	R:R:F315	16.08	No	No	0	7	6
160	R:R:G328	R:R:P332	4.06	No	No	0	9	9
161	R:R:F335	R:R:P332	4.33	Yes	No	0	5	9
162	R:R:F335	R:R:V336	7.87	Yes	No	0	5	7
163	R:R:F335	R:R:I363	3.77	Yes	No	0	5	7
164	R:R:R343	R:R:W339	4	Yes	Yes	3	8	8
165	R:R:K359	R:R:W339	4.64	Yes	Yes	3	3	8
166	R:R:I363	R:R:W339	16.44	No	Yes	3	7	8
167	R:R:V340	R:R:W352	8.58	No	No	0	5	8
168	R:R:K359	R:R:V342	4.55	Yes	No	0	3	5
169	R:R:R343	R:R:W352	11	Yes	No	0	8	8
170	R:R:R343	R:R:S356	9.22	Yes	No	3	8	4
171	R:R:K359	R:R:R343	12.38	Yes	Yes	3	3	8
172	R:R:K360	R:R:S355	4.59	Yes	No	1	7	7
173	R:R:K359	R:R:S356	6.12	Yes	No	3	3	4
174	R:R:N358	R:R:W361	7.91	No	Yes	0	4	8
175	R:R:K360	R:R:Q364	6.78	Yes	Yes	1	7	7
176	R:R:K360	R:R:Y429	15.53	Yes	Yes	1	7	6
177	R:R:Q364	R:R:W361	7.67	Yes	Yes	1	7	8
178	R:R:Q364	R:R:Y429	10.15	Yes	Yes	1	7	6
179	R:R:L368	R:R:M425	7.07	No	Yes	0	4	6
180	R:R:I371	R:R:Y421	8.46	No	Yes	2	7	8
181	R:R:I371	R:R:M425	5.83	No	Yes	0	7	6
182	R:R:F417	R:R:N374	10.87	Yes	No	0	9	9
183	R:R:F375	R:R:I379	6.28	No	No	0	7	5
184	R:R:F375	R:R:I422	5.02	No	No	0	7	5
185	R:R:F378	R:R:V382	5.24	No	No	0	9	7
186	R:R:F378	R:R:F417	16.08	No	Yes	0	9	9
187	R:R:F378	R:R:V419	7.87	No	No	0	9	7
188	R:R:N380	R:R:R383	9.64	No	No	0	8	8
189	R:R:F417	R:R:I381	3.77	Yes	No	0	9	9
190	R:R:K388	R:R:V384	4.55	No	No	0	9	8
191	R:R:L385	R:R:S409	4.5	No	No	0	8	9
192	R:R:R390	R:R:T387	5.17	No	No	0	6	7
193	R:R:L389	R:R:Q402	6.65	No	No	0	8	6
194	R:R:R400	R:R:Y403	5.14	No	No	0	8	7
195	R:R:K405	R:R:S409	6.12	No	No	0	8	9
196	R:R:L407	R:R:L411	4.15	No	No	0	8	8
197	R:R:I458	R:R:V412	4.61	No	No	0	8	8
198	R:R:F417	R:R:L413	6.09	Yes	No	0	9	9
199	R:R:M414	R:R:V419	4.56	No	No	0	8	7
200	R:R:F417	R:R:L416	4.87	Yes	No	0	9	9
201	R:R:L416	R:R:Y459	12.89	No	Yes	0	9	8
202	R:R:H420	R:R:Y421	13.07	Yes	Yes	2	8	8
203	R:R:F447	R:R:H420	12.44	No	Yes	0	5	8
204	R:R:H420	R:R:N448	7.65	Yes	No	2	8	6
205	R:R:H420	R:R:Q451	9.89	Yes	Yes	2	8	9
206	R:R:N448	R:R:Y421	11.63	No	Yes	2	6	8
207	R:R:Q451	R:R:Y421	9.02	Yes	Yes	2	9	8
208	R:R:I422	R:R:M425	4.37	No	Yes	0	5	6
209	R:R:F424	R:R:V423	5.24	No	No	9	7	6
210	R:R:V423	R:R:Y443	8.83	No	No	9	6	4
211	R:R:F424	R:R:Q440	11.71	No	No	0	7	6
212	R:R:F424	R:R:Y443	11.35	No	No	9	7	4
213	R:R:L436	R:R:T427	4.42	No	No	0	4	5
214	R:R:Q440	R:R:T427	11.34	No	No	0	6	5
215	R:R:T430	R:R:W437	6.06	No	Yes	0	5	5
216	R:R:V432	R:R:W437	9.81	Yes	Yes	1	5	5
217	R:R:M441	R:R:W437	15.12	Yes	Yes	1	6	5
218	R:R:H442	R:R:Q438	7.42	Yes	No	5	5	4
219	R:R:F447	R:R:Y443	25.79	No	No	0	5	4
220	R:R:E444	R:R:N448	9.2	No	No	0	7	6
221	R:R:F450	R:R:L446	6.09	No	No	0	7	5
222	R:R:F450	R:R:F454	6.43	No	No	0	7	6
223	R:R:F453	R:R:I457	8.79	No	No	0	6	6
224	R:R:V455	R:R:Y459	3.79	No	Yes	0	9	8
225	R:R:F461	R:R:I457	3.77	No	No	0	8	6
226	R:R:I458	R:R:Y459	9.67	No	Yes	0	8	8
227	R:R:E465	R:R:N463	5.26	No	No	0	9	9
228	R:R:N463	R:R:V466	7.39	No	No	0	9	9
229	R:R:T478	R:R:W474	10.92	No	No	0	4	5
230	L:L:I15	L:L:R19	3.76	No	No	0	0	0
231	R:R:T192	R:R:Y191	3.75	No	Yes	0	7	7
232	R:R:G194	R:R:S449	3.71	No	No	0	9	9
233	R:R:G452	R:R:S198	3.71	No	No	0	9	9
234	R:R:V365	R:R:W361	3.68	No	Yes	0	5	8
235	L:L:F23	L:L:L27	3.65	Yes	No	0	0	0
236	R:R:F324	R:R:L304	3.65	Yes	No	0	7	5
237	R:R:A205	R:R:C460	3.61	No	No	0	9	9
238	R:R:P130	R:R:V129	3.53	No	No	0	5	5
239	R:R:P366	R:R:V365	3.53	No	No	0	9	5
240	R:R:P415	R:R:V455	3.53	No	No	0	9	9
241	L:L:I15	L:L:W14	3.52	No	Yes	0	0	0
242	R:R:L321	R:R:Y221	3.52	No	No	0	6	7
243	R:R:I362	R:R:W339	3.52	No	Yes	0	8	8
244	R:R:P428	R:R:T427	3.5	No	No	0	7	5
245	R:R:E469	R:R:R214	3.49	No	No	0	9	7
246	R:R:E465	R:R:R219	3.49	No	Yes	0	9	9
247	R:R:A456	R:R:S201	3.42	No	No	0	8	8
248	R:R:A347	R:R:S356	3.42	No	No	0	7	4
249	R:R:L481	R:R:W477	3.42	No	No	0	4	4
250	R:R:A347	R:R:T349	3.36	No	No	0	7	5
251	R:R:G418	R:R:H420	3.18	No	Yes	0	9	8
252	R:R:A456	R:R:L202	3.15	No	No	0	8	9
253	R:R:F324	R:R:Y305	3.09	Yes	No	0	7	8
254	R:R:F324	R:R:Y320	3.09	Yes	No	0	7	4
255	R:R:I208	R:R:V204	3.07	No	No	0	8	5
256	R:R:I310	R:R:V384	3.07	No	No	0	8	8
257	R:R:I470	R:R:V466	3.07	No	No	0	5	9
258	R:R:M32	R:R:V31	3.04	No	No	0	6	6
259	R:R:M425	R:R:V372	3.04	Yes	No	0	6	4
260	R:R:M32	R:R:T349	3.01	No	No	0	6	5
261	R:R:F450	R:R:G194	3.01	No	No	0	7	9
262	R:R:F230	R:R:G452	3.01	Yes	No	0	8	9
263	R:R:L289	R:R:V285	2.98	Yes	No	0	7	6
264	R:R:L346	R:R:V342	2.98	No	No	0	3	5
265	R:R:L321	R:R:T325	2.95	No	No	0	6	5
266	R:R:L346	R:R:T345	2.95	No	No	0	3	3
267	R:R:L406	R:R:T410	2.95	No	No	0	8	9
268	L:L:Q10	R:R:V432	2.87	No	Yes	0	0	5
269	R:R:I381	R:R:L385	2.85	No	No	0	9	8
270	R:R:L202	R:R:M231	2.83	No	No	0	9	8
271	R:R:Q401	R:R:T399	2.83	No	No	0	6	6
272	R:R:L209	R:R:N220	2.75	No	No	0	7	9
273	R:R:E465	R:R:L215	2.65	No	No	0	9	9
274	R:R:I190	R:R:R186	2.51	No	Yes	0	6	5
275	R:R:K408	R:R:R404	2.48	No	No	0	8	6
276	R:R:E35	R:R:F39	2.33	No	No	0	5	7
277	R:R:E182	R:R:R186	2.33	No	Yes	0	2	5
278	R:R:G277	R:R:G350	2.11	No	No	0	4	5
279	R:R:F39	R:R:Y134	2.06	No	No	0	7	5
280	R:R:A333	R:R:G330	1.95	No	No	0	5	7
281	R:R:C131	R:R:P132	1.88	No	No	0	9	9
282	R:R:G194	R:R:V193	1.84	No	No	0	9	6
283	R:R:G280	R:R:V283	1.84	No	No	0	4	4
284	R:R:A313	R:R:S308	1.71	No	No	0	7	7
285	R:R:A144	R:R:V129	1.7	No	No	0	7	5
286	R:R:G464	R:R:N463	1.7	No	No	0	7	9
287	R:R:C462	R:R:I457	1.64	No	No	0	6	6
288	R:R:S196	R:R:V193	1.62	No	No	0	7	6
289	R:R:S196	R:R:V197	1.62	No	No	0	7	5
290	R:R:A313	R:R:K318	1.61	No	No	0	7	5
291	R:R:V235	R:R:V239	1.6	No	No	0	4	5
292	R:R:V239	R:R:V243	1.6	No	No	0	5	5
293	R:R:V334	R:R:V338	1.6	No	No	0	4	5
294	R:R:V338	R:R:V342	1.6	No	No	0	5	5
295	R:R:S341	R:R:T345	1.6	No	No	0	5	3
296	R:R:S475	R:R:T478	1.6	No	No	0	4	4
297	R:R:C281	R:R:L244	1.59	No	Yes	0	9	5
298	R:R:A234	R:R:L199	1.58	No	No	0	8	7
299	R:R:A313	R:R:L309	1.58	No	No	0	7	8
300	R:R:A344	R:R:N348	1.56	No	No	0	4	7
301	R:R:K472	R:R:S475	1.53	No	No	0	7	4
302	R:R:M189	R:R:V193	1.52	No	No	0	4	6
303	R:R:K408	R:R:V412	1.52	No	No	0	8	8
304	R:R:M414	R:R:T410	1.51	No	No	0	8	9
305	R:R:K388	R:R:T387	1.5	No	No	0	9	7
306	R:R:L436	R:R:V439	1.49	No	No	0	4	5
307	R:R:L389	R:R:T392	1.47	No	No	0	8	7
308	R:R:L479	R:R:T478	1.47	No	No	0	4	4
309	R:R:K34	R:R:M32	1.44	No	No	0	4	6
310	R:R:G323	R:R:W322	1.41	No	No	0	1	3
311	R:R:E391	R:R:T387	1.41	No	No	0	7	7
312	R:R:L411	R:R:M414	1.41	No	No	0	8	8
313	R:R:L40	R:R:L41	1.38	No	No	0	5	8
314	R:R:L389	R:R:L406	1.38	No	No	0	8	8
315	R:R:E469	R:R:K472	1.35	No	No	0	9	7
316	R:R:R476	R:R:S475	1.32	No	No	0	7	4
317	R:R:S316	R:R:Y320	1.27	No	No	0	7	4
318	L:L:I31	R:R:Y145	1.21	No	No	0	0	4
319	R:R:D185	R:R:F184	1.19	No	Yes	0	2	6
320	R:R:E317	R:R:Y320	1.12	No	No	0	6	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?0	6.88	4	1	0
2	L:L:Q6	8.1525	4	1	0
3	L:L:H9	8.0725	4	1	0
4	L:L:W14	12.6475	4	0	0
5	L:L:F23	5.3775	4	0	0
6	R:R:F184	4.162	5	1	6
7	R:R:R186	4.775	4	5	5
8	R:R:Y191	6.83167	6	4	7
9	R:R:Y195	7.89	5	4	7
10	R:R:R219	5.4	4	6	9
11	R:R:F230	8.348	5	2	8
12	R:R:I237	4.832	5	4	7
13	R:R:L244	4.8175	4	0	5
14	R:R:F288	7.238	5	0	7
15	R:R:L289	4.53	4	3	7
16	R:R:Y290	6.654	5	7	9
17	R:R:N295	10.75	4	2	8
18	R:R:Y296	9.245	4	2	7
19	R:R:W298	10.01	5	0	9
20	R:R:E302	9.4825	4	0	9
21	R:R:F324	4.425	4	0	7
22	R:R:F335	5.0325	4	0	5
23	R:R:W339	6.632	5	3	8
24	R:R:R343	9.15	4	3	8
25	R:R:K359	6.9225	4	3	3
26	R:R:K360	8.69	4	1	7
27	R:R:W361	7.3725	4	1	8
28	R:R:Q364	6.542	5	1	7
29	R:R:F417	7.7	6	0	9
30	R:R:H420	9.246	5	2	8
31	R:R:Y421	12.01	5	2	8
32	R:R:M425	5.0775	4	0	6
33	R:R:Y429	11.365	4	1	6
34	R:R:V432	6.6475	4	1	5
35	R:R:W437	8.296	5	1	5
36	R:R:M441	7.9525	4	1	6
37	R:R:H442	8.365	4	5	5
38	R:R:Q451	7.515	4	2	9
39	R:R:Y459	7.6775	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?0	R:R:L368	12.7626	6.22	Yes	No	0	0	4
2	R:R:L368	R:R:M425	13.0415	7.07	No	Yes	0	4	6
3	R:R:I371	R:R:M425	15.8625	5.83	No	Yes	0	7	6
4	R:R:I371	R:R:Y421	12.8113	8.46	No	Yes	2	7	8
5	L:L:L7	R:R:M441	56.4397	5.65	No	Yes	0	0	6
6	L:L:L7	R:R:M445	58.2004	5.65	No	No	0	0	6
7	L:L:E4	R:R:M445	29.6887	8.12	No	No	0	0	6
8	L:L:E4	R:R:Y195	27.9475	5.61	No	Yes	4	0	7
9	R:R:M445	R:R:Y191	30.3599	7.18	No	Yes	0	6	7
10	R:R:Y191	R:R:Y195	34.9514	7.94	Yes	Yes	4	7	7
11	L:L:H9	L:L:M8	12.7205	5.25	Yes	No	0	0	0
12	L:L:M8	R:R:F288	14.8865	6.22	No	Yes	0	0	7
13	R:R:F288	R:R:I237	42.4157	3.77	Yes	Yes	0	7	7
14	R:R:I237	R:R:Y195	41.5824	7.25	Yes	Yes	4	7	7
15	R:R:L292	R:R:R233	10.0843	7.29	No	No	0	6	8
16	R:R:R233	R:R:Y195	100	7.2	No	Yes	0	8	7
17	R:R:F184	R:R:W437	37.1077	5.01	Yes	Yes	1	6	5
18	L:L:R11	R:R:F184	10.3761	5.34	No	Yes	0	0	6
19	L:L:R11	R:R:Y245	12.0623	16.46	No	No	0	0	4
20	R:R:F184	R:R:R181	41.6829	5.34	Yes	No	0	6	3
21	L:L:W14	R:R:R181	39.7892	33.99	Yes	No	0	0	3
22	L:L:R21	L:L:W14	27.4287	4	No	Yes	0	0	0
23	L:L:D17	L:L:R21	25.7263	9.53	No	No	0	0	0
24	L:L:D17	L:L:R20	23.9202	11.91	No	No	0	0	0
25	L:L:R20	R:R:E35	22.0979	9.3	No	No	0	0	5
26	R:R:F288	R:R:L289	41.9001	4.87	Yes	Yes	0	7	7
27	R:R:L289	R:R:W339	35.5091	4.56	Yes	Yes	3	7	8
28	R:R:R343	R:R:W339	24.1278	4	Yes	Yes	3	8	8
29	R:R:R343	R:R:S356	11.5499	9.22	Yes	No	3	8	4
30	R:R:A347	R:R:S356	20.1751	3.42	No	No	0	7	4
31	R:R:A347	R:R:T349	17.2925	3.36	No	No	0	7	5
32	R:R:M32	R:R:T349	14.4034	3.01	No	No	0	6	5
33	R:R:K359	R:R:W339	21.2808	4.64	Yes	Yes	3	3	8
34	R:R:K359	R:R:S356	11.4981	6.12	Yes	No	3	3	4
35	R:R:E35	R:R:F39	13.0156	2.33	No	No	0	5	7
36	R:R:F39	R:R:Y134	11.1608	2.06	No	No	0	7	5
37	R:R:L187	R:R:M441	13.797	4.24	No	Yes	0	5	6
38	R:R:H442	R:R:L187	11.845	12.86	Yes	No	0	5	5
39	R:R:F288	R:R:K240	14.8087	17.37	Yes	No	0	7	7
40	R:R:S449	R:R:Y195	22.2827	11.45	No	Yes	0	9	7
41	R:R:G194	R:R:S449	21.0117	3.71	No	No	0	9	9
42	R:R:G194	R:R:V193	15.9274	1.84	No	No	0	9	6
43	R:R:S196	R:R:V193	13.3917	1.62	No	No	0	7	6
44	R:R:S196	R:R:V197	12.192	1.62	No	No	0	7	5
45	R:R:F453	R:R:V197	11.1349	5.24	No	No	0	6	5
46	R:R:Q451	R:R:Y421	13.2069	9.02	Yes	Yes	2	9	8
47	R:R:F230	R:R:Q451	22.6329	7.03	Yes	Yes	2	8	9
48	R:R:F230	R:R:L226	50.7523	6.09	Yes	No	0	8	9
49	R:R:E302	R:R:L226	98.7873	11.93	Yes	No	0	9	9
50	R:R:E302	R:R:H223	55.8041	9.85	Yes	No	0	9	9
51	R:R:H223	R:R:R219	47.179	7.9	No	Yes	0	9	9
52	R:R:N220	R:R:R219	14.9189	6.03	No	Yes	6	9	9
53	R:R:L209	R:R:N220	13.3106	2.75	No	No	0	7	9
54	R:R:E465	R:R:R219	31.4137	3.49	No	Yes	0	9	9
55	R:R:E465	R:R:N463	10.7555	5.26	No	No	0	9	9
56	R:R:E465	R:R:L215	19.4585	2.65	No	No	0	9	9
57	R:R:F212	R:R:L215	17.714	4.87	No	No	0	7	9
58	R:R:E469	R:R:F212	14.2899	12.83	No	No	0	9	7
59	R:R:N295	R:R:R233	95.0292	12.05	Yes	No	0	8	8
60	R:R:N295	R:R:S229	60.7004	5.96	Yes	No	0	8	9
61	R:R:S229	R:R:W298	48.8975	7.41	No	Yes	0	9	9
62	R:R:F230	R:R:N295	45.8204	19.33	Yes	Yes	2	8	8
63	R:R:L226	R:R:S229	59.8379	4.5	No	No	0	9	9
64	R:R:V301	R:R:W298	36.6796	4.9	No	Yes	0	8	9
65	R:R:F324	R:R:V301	35.4053	7.87	Yes	No	0	7	8
66	R:R:H223	R:R:Y459	14.1699	4.36	No	Yes	0	9	8
67	R:R:E302	R:R:L416	45.7296	7.95	Yes	No	0	9	9
68	R:R:L416	R:R:Y459	13.6543	12.89	No	Yes	0	9	8
69	R:R:F288	R:R:S236	10.6647	3.96	Yes	No	0	7	7
70	R:R:F291	R:R:S236	10.2983	9.25	No	No	0	5	7
71	R:R:R343	R:R:W352	11.7996	11	Yes	No	0	8	8
72	R:R:F291	R:R:Y290	10.2789	5.16	No	Yes	0	5	9
73	R:R:W329	R:R:Y290	26.2581	7.72	No	Yes	7	9	9
74	R:R:V336	R:R:Y290	17.1563	6.31	No	Yes	0	7	9
75	R:R:F335	R:R:I363	16.7607	3.77	Yes	No	0	5	7
76	R:R:F335	R:R:V336	16.6245	7.87	Yes	No	0	5	7
77	R:R:F324	R:R:L304	20.9598	3.65	Yes	No	0	7	5
78	R:R:F417	R:R:L416	36.5467	4.87	Yes	No	0	9	9
79	R:R:L304	R:R:L377	15.5123	4.15	No	No	0	5	7
80	R:R:H307	R:R:L377	14.1342	5.14	No	No	0	8	7
81	R:R:F378	R:R:F417	20.4702	16.08	No	Yes	0	9	9
82	R:R:F378	R:R:V419	16.8061	7.87	No	No	0	9	7
83	R:R:M414	R:R:V419	14.9643	4.56	No	No	0	8	7
84	R:R:I458	R:R:Y459	12.8891	9.67	No	Yes	0	8	8
85	R:R:F447	R:R:H420	16.3975	12.44	No	Yes	0	5	8
86	R:R:F447	R:R:Y443	14.6012	25.79	No	No	0	5	4
87	R:R:F424	R:R:Y443	10.9695	11.35	No	No	9	7	4
88	R:R:E469	R:R:K472	10.7555	1.35	No	No	0	9	7
89	R:R:W298	R:R:W329	27.2892	16.87	Yes	No	0	9	9
90	R:R:L244	R:R:Y245	14.2283	9.38	Yes	No	0	5	4
91	R:R:K240	R:R:L244	20.3113	4.23	No	Yes	0	7	5
92	R:R:H420	R:R:Q451	16.6537	9.89	Yes	Yes	2	8	9
93	R:R:M441	R:R:W437	41.4981	15.12	Yes	Yes	1	6	5
94	R:R:I363	R:R:W339	12.5259	16.44	No	Yes	3	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?0	R:R:W361	10.23	1	Yes	Yes	0	8	0	1
L:L:?0	R:R:Q364	3.99	1	Yes	Yes	0	7	0	1
L:L:?0	R:R:L368	6.22	1	Yes	No	0	4	0	1
L:L:A1	R:R:Y429	4	1	No	Yes	0	6	0	1
L:L:A3	R:R:E444	6.03	0	No	No	0	7	0	1
L:L:E4	R:R:Y195	5.61	4	No	Yes	0	7	0	1
L:L:E4	R:R:I237	4.1	4	No	Yes	0	7	0	1
L:L:E4	R:R:M445	8.12	4	No	No	0	6	0	1
L:L:I5	R:R:Q364	4.12	0	No	Yes	0	7	0	1
L:L:Q6	R:R:Y429	15.78	1	Yes	Yes	0	6	0	1
L:L:Q6	R:R:W437	5.48	1	Yes	Yes	0	5	0	1
L:L:Q6	R:R:M441	6.8	1	Yes	Yes	0	6	0	1
L:L:L7	R:R:M441	5.65	0	No	Yes	0	6	0	1
L:L:L7	R:R:M445	5.65	0	No	No	0	6	0	1
L:L:M8	R:R:F288	6.22	0	No	Yes	0	7	0	1
L:L:M8	R:R:D353	11.09	0	No	No	0	5	0	1
L:L:H9	R:R:S355	12.55	1	Yes	No	0	7	0	1
L:L:H9	R:R:K360	7.86	1	Yes	Yes	0	7	0	1
L:L:R11	R:R:F184	5.34	0	No	Yes	0	6	0	1
L:L:R11	R:R:Y245	16.46	0	No	No	0	4	0	1
L:L:A12	R:R:D353	6.18	0	No	No	0	5	0	1
L:L:W14	R:R:R181	33.99	0	Yes	No	0	3	0	1
L:L:Q16	R:R:L354	6.65	0	No	No	0	5	0	1
L:L:R19	R:R:T33	6.47	0	No	No	0	7	0	1
L:L:R20	R:R:E35	9.3	0	No	No	0	5	0	1
L:L:F23	R:R:E35	5.83	0	Yes	No	0	5	0	1
L:L:F23	R:R:E36	5.83	0	Yes	No	0	6	0	1
R:R:E180	R:R:R181	9.3	0	No	No	3	3	2	1
R:R:E180	R:R:V432	9.98	0	No	Yes	3	5	2	1
R:R:F184	R:R:R181	5.34	1	Yes	No	6	3	1	1
R:R:F184	R:R:V432	3.93	1	Yes	Yes	6	5	1	1
R:R:F184	R:R:W437	5.01	1	Yes	Yes	6	5	1	1
R:R:L187	R:R:M441	4.24	0	No	Yes	5	6	2	1
R:R:Y191	R:R:Y195	7.94	4	Yes	Yes	7	7	2	1
R:R:I237	R:R:Y191	4.84	4	Yes	Yes	7	7	1	2
R:R:D241	R:R:Y191	11.49	4	No	Yes	8	7	2	2
R:R:M445	R:R:Y191	7.18	0	No	Yes	6	7	1	2
R:R:R233	R:R:Y195	7.2	0	No	Yes	8	7	2	1
R:R:I237	R:R:Y195	7.25	4	Yes	Yes	7	7	1	1
R:R:S449	R:R:Y195	11.45	0	No	Yes	9	7	2	1
R:R:F288	R:R:S236	3.96	0	Yes	No	7	7	1	2
R:R:D241	R:R:I237	4.2	4	No	Yes	8	7	2	1
R:R:F288	R:R:I237	3.77	0	Yes	Yes	7	7	1	1
R:R:D241	R:R:K240	5.53	4	No	No	8	7	2	2
R:R:K240	R:R:L244	4.23	0	No	Yes	7	5	2	2
R:R:F288	R:R:K240	17.37	0	Yes	No	7	7	1	2
R:R:L244	R:R:Y245	9.38	0	Yes	No	5	4	2	1
R:R:D353	R:R:L244	4.07	0	No	Yes	5	5	1	2
R:R:F288	R:R:L289	4.87	0	Yes	Yes	7	7	1	2
R:R:K360	R:R:S355	4.59	1	Yes	No	7	7	1	1
R:R:N358	R:R:W361	7.91	0	No	Yes	4	8	2	1
R:R:K360	R:R:Q364	6.78	1	Yes	Yes	7	7	1	1
R:R:K360	R:R:Y429	15.53	1	Yes	Yes	7	6	1	1
R:R:Q364	R:R:W361	7.67	1	Yes	Yes	7	8	1	1
R:R:Q364	R:R:Y429	10.15	1	Yes	Yes	7	6	1	1
R:R:L368	R:R:M425	7.07	0	No	Yes	4	6	1	2
R:R:T430	R:R:W437	6.06	0	No	Yes	5	5	2	1
R:R:V432	R:R:W437	9.81	1	Yes	Yes	5	5	1	1
R:R:M441	R:R:W437	15.12	1	Yes	Yes	6	5	1	1
R:R:E444	R:R:N448	9.2	0	No	No	7	6	1	2
R:R:V365	R:R:W361	3.68	0	No	Yes	5	8	2	1
L:L:Q10	R:R:V432	2.87	0	No	Yes	0	5	0	1
R:R:E35	R:R:F39	2.33	0	No	No	5	7	1	2
L:L:I31	R:R:Y145	1.21	0	No	No	0	4	0	1
R:R:D185	R:R:F184	1.19	0	No	Yes	2	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8YFO_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.77
Number of Linked Nodes	295
Number of Links	320
Number of Hubs	39
Number of Links mediated by Hubs	142
Number of Communities	9
Number of Nodes involved in Communities	49
Number of Links involved in Communities	64

Path Summary
Number Of Nodes in MetaPath	95
Number Of Links MetaPath	94
Number of Shortest Paths	70127
Length Of Smallest Path	3
Average Path Length	14.8662
Length of Longest Path	33
Minimum Path Strength	1.195
Average Path Strength	7.51755
Maximum Path Strength	21.645
Minimum Path Correlation	0.7
Average Path Correlation	0.960292
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	61.7323
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.6615
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • ossification • bone mineralization • animal organ development • anatomical structure development • biomineral tissue development • tissue development • multicellular organism development • skeletal system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • osteoblast development • cellular developmental process • cell differentiation • cell development • osteoblast differentiation • embryo development ending in birth or egg hatching • chordate embryonic development • embryo development • in utero embryonic development • anatomical structure maturation • cell maturation • developmental maturation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • cell surface receptor signaling pathway • negative regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • phospholipase C-activating G protein-coupled receptor signaling pathway • connective tissue development • chondrocyte differentiation • cartilage development • regulation of inositol phosphate biosynthetic process • alcohol metabolic process • positive regulation of phosphate metabolic process • inositol phosphate metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • phosphate-containing compound metabolic process • polyol biosynthetic process • small molecule metabolic process • phosphorus metabolic process • regulation of carbohydrate metabolic process • regulation of biosynthetic process • carbohydrate metabolic process • polyol metabolic process • positive regulation of phosphorus metabolic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • carbohydrate biosynthetic process • primary metabolic process • positive regulation of inositol phosphate biosynthetic process • biosynthetic process • organophosphate metabolic process • organophosphate biosynthetic process • inositol phosphate biosynthetic process • alcohol biosynthetic process • metabolic process • regulation of phosphorus metabolic process • positive regulation of carbohydrate metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • tissue homeostasis • bone resorption • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • cellular anatomical structure • organelle lumen • organelle • membraneless organelle • nuclear lumen
Gene Ontology	Cellular Component	• membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • cellular anatomical structure • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • apical part of cell • membrane • plasma membrane • plasma membrane region • apical plasma membrane • cytoplasm • cytosol • basal part of cell • basal plasma membrane • basolateral plasma membrane • protein-containing complex • receptor complex • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ACE
PDB Residues	L:L:?0
Environment Details	Open EMBL-EBI Page
Code	ACE
Name	ACETYL GROUP
Synonyms
Identifier
Formula	C2 H4 O
Molecular Weight	44.053
SMILES
PubChem	177
Formal Charge	0
Total Atoms	7
Total Chiral Atoms	0
Total Bonds	6
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q03431
Sequence	>8YFO_nogp_Chain_R V M T K E E Q I F L L A V P C P D Y I Y D F N H K G H A Y T R E R E V F D R L G M I Y T V G Y S V S L A S L T V A V L I L A Y F R R L H C T R N Y I H M H L F L S F M L R A V S I F V K D A V L Y S A G Y A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M A F F S E K K Y L W G F T V F G W G L P A V F V A V W V S V R A T L A N T G C W D L S S G N K K W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L R E T N T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M A T P Y T E V S G T L W Q V Q M H Y E M L F N S F Q G F F V A I I Y C F C N G E V Q A E I K K S W S R W T L A L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6FJ3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	-	2.5	2018-11-21	doi.org/10.1038/s41594-018-0151-4
	6NBF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	LA-PTH Analog	-	Gs/β1/γ2	3	2019-04-17	doi.org/10.1126/science.aav7942
	6NBF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	LA-PTH Analog	-		3	2019-04-17	doi.org/10.1126/science.aav7942
	6NBH	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	LA-PTH Analog	-	Gs/β1/γ2	3.5	2019-04-17	doi.org/10.1126/science.aav7942
	6NBH (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	LA-PTH Analog	-		3.5	2019-04-17	doi.org/10.1126/science.aav7942
	6NBI	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	LA-PTH Analog	-	Gs/β1/γ2	4	2019-04-17	doi.org/10.1126/science.aav7942
	6NBI (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	LA-PTH Analog	-		4	2019-04-17	doi.org/10.1126/science.aav7942
	7VVJ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVJ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVK	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.3	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVK (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.3	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVL	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVL (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVM	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVM (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVN	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVN (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	4.1	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		4.1	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	8HA0	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	2.62	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HA0 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.62	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	chim(NtGi1-Gs)/β1/γ2	3.25	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.25	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	3.76	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.76	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8FLQ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.55	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLQ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.55	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLR	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	2.94	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLR (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		2.94	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLS	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	3.09	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLS (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		3.09	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLT	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-	Gs/β1/γ2	3.03	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLT (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-		3.03	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLU	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	LA-PTH Analog	-	Gs/β1/γ2	2.76	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLU (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	LA-PTH Analog	-		2.76	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8GW8	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371	Gs/β1/γ2	2.9	2023-06-14	doi.org/10.1038/s41586-023-06169-3
	8GW8 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371		2.9	2023-06-14	doi.org/10.1038/s41586-023-06169-3
	7Y35	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	2.9	2023-07-05	To be published
	7Y35 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		2.9	2023-07-05	To be published
	7Y36	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.8	2023-07-05	To be published
	7Y36 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2023-07-05	To be published
	8JR9	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371	chim(NtGi1-Gs)/β1/γ2	2.57	2023-08-02	doi.org/10.1038/s41586-023-06467-w
	8JR9 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371		2.57	2023-08-02	doi.org/10.1038/s41586-023-06467-w
	9LXR	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	LA-PTH Analog	-	Arrestin2	3.07	2025-09-10	To be published
	9JR2	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	doi.org/10.1038/s41589-025-01957-6
	9JR2 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	doi.org/10.1038/s41589-025-01957-6
	9JR3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	doi.org/10.1038/s41589-025-01957-6
	9JR3 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	doi.org/10.1038/s41589-025-01957-6
	9B5Y	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	LA-PTH Analog	-	chim(NtGi1-Gq)/β1/γ2	3.49	2025-03-19	doi.org/10.1073/pnas.2426178122
	9B5Y (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	LA-PTH Analog	-		3.49	2025-03-19	doi.org/10.1073/pnas.2426178122
	8YFO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Ac-LA-PTH Analog	-	chim(NtGi1-Gs)/β1/γ2	2.71	2025-09-03	To be published
	8YFO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Ac-LA-PTH Analog	-		2.71	2025-09-03	To be published
	8YG4	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	LA-PTH Analog	-	chim(NtGi1-Gs)/β1/γ2	2.59	2025-09-03	To be published
	8YG4 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	LA-PTH Analog	-		2.59	2025-09-03	To be published

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